A quantitative dry blood sample collection and preservation tube and a method of collecting the same

Abstract

The application discloses a quantitative dry blood sample collecting and preserving tube and a collecting method thereof, which comprises a liquid collecting mechanism, a liquid storage tube and a dry sealing mechanism. The top air bag is matched with the blood collecting tube. When the collecting liquid is discharged, the collecting liquid can be quickly discharged by extruding the top air bag, so that the efficiency of discharging the blood into the liquid storage tube is greatly improved. The dry sealing mechanism is separated from the liquid collecting mechanism, the exposure time of the drying agent in the drying tube is reduced, the whole structure is reasonable and ingenious, and the integrated structure is realized.

Description

TECHNICAL FIELD

[0001] The present application relates to a quantitative dry blood sample collection and preservation tube and a collection method thereof. BACKGROUND

[0002] Dry blood spot detection technology is a method of adding biological samples, usually whole blood drops, to filter paper for dry preservation, and then detecting analytes in the dry spot sample after extraction. This technology was used for qualitative analysis and detection of nucleic acid genetic material in the early stage. Since it has the advantages of convenient collection, small blood volume, and easy sample preservation and transportation, it has been used for newborn screening of phenylketonuria since the 1960s. However, such a method has poor precision and poor dry preservation effect, resulting in sample contamination, deterioration, and other drawbacks. In the existing patent with publication number CN111474257A, a quantitative capillary is used for suction, but in this patent, the sample is automatically adsorbed by a collection filter paper, which has low efficiency and takes a long time. If air bubbles appear in the sample, it will hinder the automatic adsorption of the collection filter paper. In addition, the use of desiccant is not reasonable. In this patent, the desiccant and the capillary collection tube are integrated in the tube fixing part. Since the two ends of the capillary collection tube need to be in communication with the atmosphere, otherwise it will not be able to automatically suck liquid. Therefore, the upper end of the tube fixing part is open. As clearly known from the 8th and 9th lines of the 84th paragraph of the specification of this patent, the closed top end 2a1 needs to be closed by the tube cover 1b. Therefore, when the tube fixing part is extracted and blood is collected through the capillary collection tube, the desiccant will be exposed to the air. If the environmental humidity is high or the collection time is prolonged, the desiccant will lose its drying function, which will increase the risk of sample deterioration. SUMMARY

[0003] In view of the above deficiencies of the prior art, the present application solves the problem of providing a quantitative dry blood sample collection and preservation tube with fast and efficient collection and preservation, and a collection method thereof.

[0004] To solve the above problems, the technical scheme adopted by the present application is as follows:

[0005] A kind of quantitative dry blood sample collection and preservation tube, including liquid collection mechanism, liquid storage pipe, dry sealing mechanism;The liquid storage pipe is closed to the bottom and the structure of upper end opening around;The liquid collection mechanism is installed in the upper end of liquid storage pipe;The dry sealing mechanism is installed in the lower end of liquid storage pipe;The liquid collection mechanism includes top air bag and blood collection tube;The lower end of top air bag is inserted and fixed to install blood collection tube;The upper end of top air bag is provided with air hole on one side;The lower part of top air bag is inserted and fixed to the inside of the upper end of liquid storage pipe;The dry sealing mechanism includes dry tube and open-close cover;The upper end of dry tube is closed, and the lower end of dry tube is provided with open-close opening, and open-close cover is movably installed at open-close opening;The inside of dry tube is provided with drying agent;The upper end of dry tube is movably buckled with the lower end of liquid storage pipe.

[0006] Further, the inside of the liquid storage tube is provided with a blood absorption filter paper below.

[0007] Further, the blood collection tube is a capillary glass tube.

[0008] Further, the top air bag is provided with a limiting ring around; the upper end of the liquid storage tube is provided with a ring-shaped flange; the lower side of the limiting ring is in contact with the upper side of the ring-shaped flange.

[0009] Further, the lower end of the dry tube is provided with a threaded ring surface outside around; the upper end of the open-close cover is provided with an internal thread sleeve; the upper end of the open-close cover is provided with a sealing plug; the sealing plug is inserted and fixed on the open-close opening; the internal thread sleeve is screwed on the threaded ring surface of the lower end of the dry tube.

[0010] Further, the lower end of the liquid storage tube is provided with a clamping ring outside around; the upper end of the dry tube is provided with a butt ring, and the inner side of the butt ring is provided with a clamping ring groove around; the butt ring is inserted into the lower end of the liquid storage tube; the clamping ring groove is inserted and buckled with the clamping ring.

[0011] Further, the outer side of the dry tube is provided with a positioning ring convex around; the inner side of the upper end of the liquid storage tube is provided with a positioning ring groove around; the positioning ring convex and the positioning ring groove are matched in structure; the inner cavity of the liquid storage tube and the dry tube are both cylindrical structures; the outer diameter length of the dry tube is smaller than the inner cavity diameter length of the liquid storage tube.

[0012] Further, the upper end of the dry tube is provided with a butt ring, and the inner side of the butt ring is provided with a clamping ring groove around; the diameter length of the butt ring is greater than the inner diameter length of the liquid storage tube; one side of the upper end of the liquid storage tube is provided with a connecting soft strip, and the outer end of the connecting soft strip is provided with a pressing plate; one side of the pressing plate is provided with a pressing ring, and the outer side of the pressing ring is provided with a pressing ring convex around; the size of the pressing ring and the butt ring is matched; the size of the pressing ring convex and the clamping ring groove is matched.

[0013] Further, the inside of the drying tube is provided with a barrier net below; the drying agent is located at the upper end of the barrier net.

[0014] A collection method of a quantitative dry blood sample collection and preservation tube, steps are as follows:

[0015] S1, the top air bag and the blood collection tube are taken out from the upper end of the liquid storage tube, the lower end of the blood collection tube is contacted with the blood to be collected, and the automatic suction quantitative blood sample is carried out;

[0016] S2, after the blood collection is completed, the top air bag and the blood collection tube are inserted into the inside of the upper end of the liquid storage tube again, the top air bag is squeezed, the blood sample is squeezed into the inside below the liquid storage tube, and then the top air bag and the blood collection tube are taken out again;

[0017] S3, the drying tube is taken off from the lower end of the liquid storage tube, and the opening and closing cover is separated from the lower end of the drying tube, so that the opening and closing opening of the lower end of the drying tube is opened, the lower end of the drying tube is inserted from the upper end of the liquid storage tube, and the positioning ring convex of the drying tube is buckled on the positioning ring groove of the liquid storage tube, the abutting ring body is abutted on the upper end of the liquid storage tube, the pressing ring body is inserted into the abutting ring body by turning over and pressing, the pressing ring convex is buckled into the clamping ring groove, and packaging is realized.

[0018] The beneficial effects of the present application are as follows:

[0019] The present application cooperates with the top air bag and the blood collection tube, when the collected liquid is discharged, the top air bag is squeezed to discharge quickly, which greatly improves the efficiency of discharging blood into the liquid storage tube; the liquid collection mechanism is installed at the upper end of the liquid storage tube, and the drying and sealing mechanism is installed at the lower end of the liquid storage tube, so that the drying and sealing mechanism is separated from the liquid collection mechanism, when the liquid collection is completed and the liquid enters the liquid storage tube, the liquid collection mechanism is taken out, then the drying tube is taken off from the lower end of the liquid storage tube, and the opening and closing cover is taken out from the opening and closing opening of the lower end of the drying tube, so that the lower end of the drying tube is opened, then the lower end of the drying tube is quickly inserted from the upper end of the liquid storage tube, and the positioning ring convex of the drying tube is buckled on the positioning ring groove of the liquid storage tube to realize sealing, so that the exposure time of the drying agent in the drying tube is reduced, and the whole structure is reasonable and ingenious, realizing integrated structure. BRIEF DESCRIPTION OF DRAWINGS

[0020] Fig. 1 It is a structural schematic diagram of the present application.

[0021] Fig. 2 It is a structural schematic diagram of the liquid collection mechanism of the present application.

[0022] Fig. 3 It is a structural schematic diagram of the liquid storage tube of the present application.

[0023] Fig. 4 It is a structural schematic diagram of the drying and sealing mechanism of the present application.

[0024] Fig. 5 This is a schematic diagram of the structure of the present invention, showing the insertion of the drying tube into the liquid storage tube after blood collection and storage.

[0025] Fig. 6 This is a schematic diagram of the structure after the blood collection and storage are completed and the pressure plate is sealed. Detailed Implementation

[0026] The invention will now be described in further detail with reference to the accompanying drawings.

[0027] like Figs. 1 to 6 As shown, a quantitative dried blood sample collection and preservation tube includes a collection mechanism 2, a storage tube 1, and a drying and sealing mechanism 3. The storage tube 1 has a structure that is closed on all sides and at the bottom, and open at the top. The collection mechanism 2 is installed at the upper end of the storage tube 1. The drying and sealing mechanism 3 is installed at the lower end of the storage tube 1. The collection mechanism 2 includes a top air bladder 21 and a blood collection tube 22. The lower end of the top air bladder 21 is inserted and fixedly installed with the blood collection tube 22. A vent 211 is provided on one side of the upper end of the top air bladder 21. The lower part of the top air bladder 21 is pressed and inserted into the upper end of the storage tube 1. The drying and sealing mechanism 3 includes a drying tube 31 and an opening and closing cover 33. The upper end of the drying tube 31 is closed, and the lower end of the drying tube 31 has an opening and closing opening 311, at which the opening and closing cover 33 is movably installed. A desiccant 32 is provided inside the drying tube 31. The upper end of the drying tube 31 is movably snapped to the lower end of the storage tube 1.

[0028] like Figs. 1 to 6 As shown, to improve blood absorption and prevent splashing, it is further preferred that the lower part of the liquid collection tube 1 is provided with blood-absorbing filter paper 7. More preferably, the blood collection tube 22 is a capillary glass tube.

[0029] like Figs. 1 to 6 As shown, in order to facilitate the connection between the top airbag 21 and the liquid storage tube 1, a limiting ring 212 is provided around the top airbag 21; an annular flange 11 is provided at the upper end of the liquid storage tube 1; and the lower side of the limiting ring 212 abuts against the upper side of the annular flange 11.

[0030] like Figs. 1 to 6 As shown, in order to achieve a sealed and movable connection between the drying tube 31 and the opening / closing cover 33, the lower end of the drying tube 31 is provided with a screw threaded annular surface 318 on its outer periphery; the upper end of the opening / closing cover 33 is provided with an internal threaded sleeve 331; the upper end of the opening / closing cover 33 is provided with a sealing plug 332 in the middle; the sealing plug 332 is sealed and inserted into the opening / closing opening 311; the internal threaded sleeve 331 is screwed onto the screw threaded annular surface 318 at the lower end of the drying tube 31.

[0031] likeFigs. 1 to 6 As shown in the drawings, in order to facilitate the movable connection of the lower end of the liquid storage tube 1 and the drying tube 31, further, the outer side of the lower end of the liquid storage tube 1 is provided with a clamping ring body 12; the upper end of the drying tube 31 is provided with a docking ring body 8, and the inner side of the docking ring body 8 is provided with a clamping ring groove 81; the docking ring body 8 is inserted into the lower end of the liquid storage tube 1; and the clamping ring groove 81 and the clamping ring body 12 are inserted and buckled.

[0032] As shown in the drawings, Figs. 1 to 6 In order to ensure the sealed connection of the drying tube 31 and the liquid storage tube 1 after the liquid sampling is completed, further, the outer side of the drying tube 31 is provided with a positioning ring protrusion 312; the inner side of the upper end of the liquid storage tube 1 is provided with a positioning ring groove 13; the positioning ring protrusion 312 and the positioning ring groove 13 are structurally matched; the inner cavity of the liquid storage tube 1 and the drying tube 31 are both cylindrical structures; and the outer diameter length of the drying tube 31 is smaller than the inner cavity diameter length of the liquid storage tube 1.

[0033] As shown in the drawings, Figs. 1 to 6 In order to improve the stability of the connection structure of the drying tube 31 and the liquid storage tube 1, further, the upper end of the drying tube 31 is provided with a docking ring body 8, the inner side of the docking ring body 8 is provided with a clamping ring groove 81, and the diameter length of the docking ring body 8 is greater than the inner diameter length of the liquid storage tube 1; one side of the upper end of the liquid storage tube 1 is provided with a connecting soft strip 4, the outer end of the connecting soft strip 4 is provided with a pressing plate 5, one side of the pressing plate 5 is provided with a pressing ring body 6, the outer side of the four sides of the pressing ring body 6 is provided with a pressing ring protrusion 61; the pressing ring body 6 and the docking ring body 8 are size-matched; and the pressing ring protrusion 61 and the clamping ring groove 81 are size-matched. Further, the inner lower part of the drying tube 31 is provided with a barrier net 313; and the drying agent 32 is located at the upper end of the barrier net 313.

[0034] As shown in the drawings, Figs. 1 to 6 A collection method of a quantitative dry blood sample collection and preservation tube, the steps are as follows:

[0035] S1, the top air bag 21 and the blood collection tube 22 are taken out from the upper end of the liquid storage tube 1, the lower end of the blood collection tube 22 is contacted with the blood to be collected, and the automatic suction of the quantitative blood sample is carried out.

[0036] S2, after the blood collection is completed, the top air bag 21 and the blood collection tube 22 are inserted into the inner part of the upper end of the liquid storage tube 1 again, the top air bag 21 is squeezed, so that the blood sample is squeezed into the inner lower part of the liquid storage tube 1, and then the top air bag 21 and the blood collection tube 22 are taken out again.

[0037] S3, the dry tube 31 is taken off from the lower end of the liquid storage tube 1, and the opening and closing cover 33 is separated from the lower end of the dry tube 31, so that the opening and closing opening 311 of the lower end of the dry tube 31 is opened, the lower end of the dry tube 31 is inserted from the upper end of the liquid storage tube 1, and the positioning ring convex 312 of the dry tube 31 is inserted and buckled on the positioning ring groove 13 of the liquid storage tube 1, the abutting ring body 8 abuts on the upper end of the liquid storage tube 1, the pressing plate 5 is turned over, the pressing ring body 6 is inserted into the abutting ring body 8, so that the pressing ring convex 61 is buckled into the clamping ring groove 81, and packaging is realized.

[0038] The application can quickly discharge by squeezing the top air bag 21 when discharging the collected liquid, greatly improving the efficiency of blood into the liquid storage tube; the liquid collecting mechanism 2 is installed on the upper end of the liquid storage tube 1, and the dry sealing mechanism 3 is installed on the lower end of the liquid storage tube 1, so that the dry sealing mechanism 3 is separated from the liquid collecting mechanism 2, when the liquid enters the liquid storage tube 1 after the liquid collecting is completed, the liquid collecting mechanism is taken out, then the dry tube 31 is taken off from the lower end of the liquid storage tube 1, and the opening and closing cover 33 is taken out from the opening and closing opening 311 of the lower end of the dry tube 31, so that the lower end of the dry tube 31 is opened, then the lower end of the dry tube 31 is quickly inserted from the upper end of the liquid storage tube 1, and the positioning ring convex 312 of the dry tube 31 is inserted and buckled on the positioning ring groove 13 of the liquid storage tube 1 to realize sealing, so that the exposure time of the drying agent 32 in the dry tube 31 is reduced, and the whole structure is reasonable and ingenious, realizing integrated structure.

[0039] The above only describes the preferred embodiments of the application and does not limit the application, any modification, equivalent replacement, improvement, etc. within the spirit and principle of the application should be included in the protection scope of the application.

Claims

1. A quantitative dried blood sample collection and preservation tube, characterized in that, The application relates to a blood sampling device, which comprises a liquid sampling mechanism, a liquid storage tube, a dry sealing mechanism, a top air bag and a blood sampling tube.

2. The quantitative dried blood sample collection and preservation tube of claim 1, wherein, The lower end of the top air bag is fixedly connected with the blood sampling tube through plug-in connection; the upper end of the top air bag is provided with a vent hole on one side; the lower part of the top air bag is inserted into the upper end of the liquid storage tube; the dry sealing mechanism comprises a dry tube and an opening and closing cover; the upper end of the dry tube is closed, the lower end of the dry tube is provided with an opening and closing opening, and the opening and closing cover is movably arranged on the opening and closing opening; the inside of the dry tube is provided with a drying agent; the upper end of the dry tube is movably buckled with the lower end of the liquid storage tube; the outer side of the four peripheries of the dry tube is provided with a positioning ring convex; the inside of the four peripheries of the upper end of the liquid storage tube is provided with a positioning ring groove; the positioning ring convex and the positioning ring groove are matched in structure; the inner cavities of the liquid storage tube and the dry tube are both cylindrical structures; the outer diameter length of the dry tube is smaller than the inner cavity diameter length of the liquid storage tube; the upper end of the dry tube is provided with a butt joint ring body, the inner side of the four peripheries of the butt joint ring body is provided with a clamping ring groove, and the diameter length of the butt joint ring body is larger than the inner diameter length of the liquid storage tube; one side of the upper end of the liquid storage tube is provided with a connecting soft strip, the outer end of the connecting soft strip is provided with a pressing plate, one side of the pressing plate is provided with a pressing ring body, and the outer side of the four peripheries of the pressing ring body is provided with a pressing ring convex; the pressing ring body is matched with the butt joint ring body in size; the pressing ring convex is matched with the clamping ring groove in size; the top air bag and the blood sampling tube are taken out from the upper end of the liquid storage tube, the lower end of the blood sampling tube is contacted with blood to be collected, and automatic suction of a quantitative blood sample is carried out; after blood sampling is completed, the top air bag and the blood sampling tube are inserted into the upper end of the liquid storage tube again, the top air bag is pressed, the blood sample is squeezed into the inside of the liquid storage tube, and then the top air bag and the blood sampling tube are taken out again; the dry tube is taken off from the lower end of the liquid storage tube, the opening and closing cover is separated from the lower end of the dry tube, the opening and closing opening of the lower end of the dry tube is opened, the lower end of the dry tube is inserted into the upper end of the liquid storage tube, the positioning ring convex of the dry tube is clamped on the positioning ring groove of the liquid storage tube, the butt joint ring body is abutted to the four peripheries of the upper end of the liquid storage tube, the pressing plate is turned over, the pressing ring body is inserted into the butt joint ring body, the pressing ring convex is clamped into the clamping ring groove, and packaging is realized; the inside of the lower part of the liquid storage tube is provided with a blood absorption filter paper; the blood sampling tube is a capillary glass tube.

3. The quantitative dried blood sample collection and preservation tube of claim 1, wherein, The four peripheries of the top air bag are provided with a limiting ring body; the upper end of the liquid storage tube is provided with a ring-shaped flange; the lower side of the limiting ring body is abutted to the upper side of the ring-shaped flange.

4. The quantitative dried blood sample collection and preservation tube of claim 1, wherein, The lower end of the dry tube is provided with a screw thread ring surface on the outer side of the four peripheries; the upper end of the opening and closing cover is provided with an internal thread sleeve; the upper end of the opening and closing cover is provided with a sealing plug in the middle; the sealing plug is sealingly plugged on the opening and closing opening; the internal thread sleeve is screw-threadedly connected on the screw thread ring surface of the lower end of the dry tube. The lower end of the liquid storage tube is provided with a clamping ring body on the outer side of the four peripheries; the upper end of the dry tube is provided with a butt joint ring body, and the inner side of the four peripheries of the butt joint ring body is provided with a clamping ring groove; the butt joint ring body is plugged on the lower end of the liquid storage tube; the clamping ring groove is clamped with the clamping ring body.

5. The quantitative dried blood sample collection and preservation tube of claim 1, wherein, The inside of the drying tube is provided with a barrier net below; the desiccant is located at the upper end of the barrier net.

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