A cup transfer module for a chemiluminescence detector

Abstract

The present invention discloses a reaction cup transfer module for a chemiluminescence detector. The mechanism of this reaction cup transfer module realizes the movement of reaction cups among the three positions of the reaction cup scheduling position, sample addition position, and reagent addition position in the chemiluminescence detector through a vertical transfer component and a horizontal transfer component, so as to achieve the purpose of picking and placing reaction cups and adding samples; at the same time, it has a mixing function, which can achieve efficient mixing without scheduling the reaction cups. The mixing can be carried out simultaneously with the reaction cup transfer action, greatly improving the operation efficiency of the machine and saving time.

Description

Technical Field

[0001] The present invention relates to a mechanical transmission structure, and more particularly to a reaction cup transfer module for a chemiluminescence detector. Background Art

[0002] When the energy generated by a chemical reaction of a substrate is released in the form of light, this process is called chemiluminescence. A chemiluminescence detector is an immunoassay device based on this principle. A chemiluminescence detector includes two parts: immunoassay reaction and chemiluminescence. Chemiluminescence refers to the use of a chemiluminescent substance catalyzed by a catalyst and oxidized by an oxidant to form an excited intermediate. When this excited intermediate returns to the stable ground state, photons are emitted simultaneously. A luminescence signal measuring instrument is used to measure the photon yield. The immunoassay reaction is to directly label a luminescent substance on an antigen or antibody, or an enzyme acts on a luminescent substrate.

[0003] With the development of chemiluminescence detectors, the miniaturization of instruments has received increasing attention. How to arrange various mechanisms in a limited space has become one of the key research points in this field. In the existing structure of chemiluminescence detectors, a general detection process includes: loading reaction cups at the reaction cup scheduling position, moving to the sample addition position to add samples, then moving to the reagent addition position to add reagents, then moving while mixing to the reaction cup scheduling position, and finally taking away the reaction cups with samples and reagents added for subsequent processing. The above process involves the transfer of reaction cups between various structures, and mixing is also required as needed during the transfer process. The three mechanisms of the reaction cup scheduling position, sample addition position, and reagent addition position at different positions are not on the same horizontal plane in the vertical height, resulting in the need for a reaction cup transfer module to transfer reaction cups. Summary of the Invention

[0004] Object of the Invention: Aiming at the above-mentioned prior art, a reaction cup transfer module for a chemiluminescence detector is proposed, which reduces the requirements for spatial layout during the movement between the three mechanisms of the reaction cup scheduling position, sample addition position, and reagent addition position, and at the same time has a mixing function.

[0005] Technical Solution: A reaction cup transfer module for a chemiluminescence detector includes a vertical movement component and a horizontal movement component;

[0006] The vertical movement component includes a module fixing plate, a lifting linear guide rail component, a lifting synchronous pulley belt component, and a lifting motor; the lifting linear guide rail component is arranged on the side of the vertically fixed module fixing plate, and the guide rail of the lifting linear guide rail component is inclined relative to the horizontal plane; the lifting synchronous pulley belt component includes synchronous pulleys respectively arranged at the upper and lower parts of the module fixing plate and a synchronous belt connecting the synchronous pulleys, and the synchronous belt is arranged parallel to the guide rail of the lifting linear guide rail component; the lifting motor is fixed at the upper part of the module fixing plate and is used to drive the upper synchronous pulley to rotate;

[0007] The transverse movement assembly includes a transverse movement support plate, a transverse movement linear guide assembly, a mixing rack, a reaction cup support, a reaction cup seat, a mixing gear, a transverse movement motor, and a transverse movement drive rod; the transverse movement support plate is fixedly connected to the slider of the lifting linear guide assembly; the guide rail of the transverse movement linear guide assembly is horizontally arranged, and the mixing rack is arranged in parallel above the guide rail of the transverse movement linear guide assembly; the reaction cup support is fixedly connected to the slider of the transverse movement linear guide assembly; a vertical through hole is provided on the reaction cup support, and the reaction cup seat is rotationally connected to the through hole through a bearing sleeved on the lower part; the mixing gear is fixed to the bottom end of the reaction cup seat and meshes with the mixing rack; the output shaft of the transverse movement motor faces vertically upward and is fixedly connected to one end of the transverse movement drive rod, a chute is arranged along the length direction of the transverse movement drive rod, and a vertical guide rod at the bottom of the reaction cup support is inserted into the chute, and the reaction cup seat is driven to slide horizontally by the rotation of the output shaft of the transverse movement motor.

[0008] Further, a first opto-coupler sensor for detecting the height position of the transverse movement assembly is provided on the side of the module fixing plate.

[0009] Further, a second opto-coupler sensor for detecting the rotation angle of the transverse movement drive rod is provided on the side of the output shaft of the transverse movement motor.

[0010] Further, a plurality of the through holes are provided on the reaction cup support, and each through hole is connected to one reaction cup seat.

[0011] Beneficial effects: The reaction cup moving module mechanism realizes the movement of the reaction cup among the three mechanism positions of the reaction cup scheduling position, the sample adding position, and the reagent adding position of the chemiluminescence detector through the vertical movement assembly and the transverse movement assembly, so as to achieve the purpose of picking and placing the reaction cup and adding samples. The vertical movement assembly realizes the oblique up and down movement, which can reduce the number of movement directions of the reaction cup moving module and meet the requirements of the overall machine space layout. That is, the existing reaction cup moving module needs to provide two movement directions of left and right movement and up and down movement, while the vertical movement assembly of the present invention only needs to move in an oblique direction, so that the space occupied by the corresponding mechanism inside the instrument can be reduced.

[0012] At the same time, the reaction cup moving module of the present invention has a mixing function and can achieve efficient mixing during the movement of the reaction cup or when the reaction cup temporarily stops moving. Increasing the mixing can effectively ensure the sufficiency of the reaction in the reaction cup, such as the mixing of the sample and the reagent, and the mixing during sample dilution, so as to ensure the accuracy and stability of the results. Description of the Drawings

[0013] Figure 1 Schematic three-dimensional structure of the reaction cup moving module for the chemiluminescence detector of the present invention Figure 1 ;

[0014] Figure 2Schematic three-dimensional structure of the cup transfer module for the chemiluminescence detector of the present invention Figure 2 ;

[0015] Figure 3 Schematic three-dimensional structure of the horizontal transfer component Figure 1 ;

[0016] Figure 4 Schematic three-dimensional structure of the horizontal transfer component Figure 2 ;

[0017] Figure 5 Schematic working diagram of the cup transfer module for the chemiluminescence detector of the present invention. Specific embodiments

[0018] The present invention will be further explained below with reference to the accompanying drawings.

[0019] As Figures 1 to 5 shown, a cup transfer module for a chemiluminescence detector includes a vertical transfer component and a horizontal transfer component.

[0020] The vertical transfer component includes a module fixing plate 1, a lifting linear guide rail assembly 2, a lifting synchronous pulley belt assembly 3, and a lifting motor 4. The module fixing plate 1 is a plate member obliquely fixed on the horizontal plane inside the chemiluminescence detector. The guide rail of the lifting linear guide rail assembly 2 is fixed on the side of the module fixing plate 1 and is obliquely arranged relative to the horizontal plane. The lifting synchronous pulley belt assembly 3 includes synchronous pulleys respectively arranged at the upper and lower parts of the module fixing plate 1 and a synchronous belt connecting the synchronous pulleys. The synchronous belt is arranged parallel to the guide rail of the lifting linear guide rail assembly 2. The lifting motor 4 is fixed at the upper part of the module fixing plate 1 and is used to drive the upper synchronous pulley to rotate, thereby driving the synchronous belt to move.

[0021] The horizontal translation component includes a horizontal translation support plate 5, a horizontal translation linear guide rail component 6, a mixing rack 7, a reaction cup support 8, a reaction cup seat 9, a mixing gear 10, a horizontal translation motor 11, and a horizontal translation drive rod 12. The side of the horizontal translation support plate 5 is fixedly connected to the slider of the lifting linear guide rail component 2, and the synchronous belt of the vertical translation component is connected to the horizontal translation support plate 5. The guide rail of the horizontal translation linear guide rail component 6 is horizontally fixed below the horizontal plane of the horizontal translation support plate 5, and the mixing rack 7 is fixed above the horizontal plane of the horizontal translation support plate 5 and is arranged parallel to the guide rail of the horizontal translation linear guide rail component 6. The reaction cup support 8 is connected to the slider through an L-shaped connecting piece. Specifically, the horizontal side of the L-shaped connecting piece is fixedly connected to the slider of the horizontal translation linear guide rail component 6, and the top of the vertical side of the L-shaped connecting piece is fixedly connected to the reaction cup support 8. The reaction cup support 8 is provided with two vertical through holes, and the two reaction cup seats 9 are respectively rotationally connected to one through hole through bearings sleeved on the lower part. The bottom end of each reaction cup seat 9 is fixedly connected with a mixing gear 10, and the mixing gear 10 meshes with the mixing rack 7. The horizontal translation motor 11 is fixed at the lower part of the horizontal translation support plate 5, the output shaft of the horizontal translation motor 11 faces vertically upward and is fixedly connected to the end of the horizontal translation drive rod 12. A chute is arranged along the length direction at the front part of the horizontal translation drive rod 12, and the vertical guide rod at the bottom of the reaction cup support 8 is inserted into the chute. The rotation of the output shaft of the horizontal translation motor 11 drives the reaction cup seat 9 to slide horizontally.

[0022] The working principle of the cup transfer module for the chemiluminescence detector of the present invention is as follows: The horizontal translation component is connected to the slide rail of the vertical translation component through a slider, so that the horizontal translation component can slide obliquely up and down relative to the module fixing plate 1, and the lifting synchronous pulley belt component 3 on the module fixing plate 1 drives the up and down movement of the horizontal translation component. When the horizontal translation motor 11 of the horizontal translation component rotates, it drives the horizontal translation drive rod 12 to rotate horizontally around the end, and the chute at the front part of the horizontal translation drive rod 12 drives the vertical guide rod at the bottom of the reaction cup support 8 to slide in the chute, that is, the rotational motion of the horizontal translation drive rod 12 is converted into a linear motion, so that the reaction cup support 8 moves horizontally on the guide rail of the horizontal translation linear guide rail component 6. During the horizontal movement of the reaction cup support 8 on the horizontal translation linear guide rail component 6, since the mixing gear 10 at the bottom of the reaction cup seat 9 meshes with the mixing rack 7, the reaction cup seat 9 rotates simultaneously during the horizontal movement, realizing effective mixing of the reaction cups on the reaction cup seat 9. Correspondingly, the reaction cup scheduling position of the chemiluminescence detector can be set at the upper part of the module fixing plate 1; the sample adding position can be set at the position between the vertical heights of the module fixing plate 1; the reagent adding position can be set at the lower part of the module fixing plate 1; the horizontal distances of the three structures relative to the module fixing plate 1 can also be adjusted within the moving stroke range of the horizontal translation component.

[0023] Such as Figure 2As shown, several first optocoupler sensors 13 for detecting the height position of the transverse movement assembly are provided on the side of the module fixing plate 1. The first optocoupler sensors 13 can be respectively arranged at the upper, middle and lower parts of the module fixing plate 1 to detect the height positions of different parts of the transverse movement assembly. As Figure 5 Shown is a schematic diagram of the transverse movement assembly running to the top.

[0024] As Figure 3 , Figure 4 Shown, a second optocoupler sensor 14 for detecting the rotation angle of the transverse movement drive rod 12 is provided on the side of the output shaft of the transverse movement motor 11. In this embodiment, there are two second optocoupler sensors 14, which respectively detect the positions of the transverse movement assembly running to both sides; correspondingly, an optocoupler baffle cooperating with the second optocoupler sensor 14 is provided at the end of the transverse movement drive rod 12.

[0025] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A cup transfer module for a chemiluminescence detector, characterized in that, It includes a vertical movement component and a horizontal movement component; The vertical movement component includes a module fixing plate (1), a lifting linear guide rail component (2), a lifting synchronous pulley belt component (3), and a lifting motor (4); the lifting linear guide rail component (2) is arranged on the side of the vertically fixed module fixing plate (1), and the guide rail of the lifting linear guide rail component (2) is inclined relative to the horizontal plane; the lifting synchronous pulley belt component (3) includes synchronous pulleys respectively arranged at the upper and lower parts of the module fixing plate (1) and a synchronous belt connecting the synchronous pulleys, and the synchronous belt is arranged parallel to the guide rail of the lifting linear guide rail component (2); the lifting motor (4) is fixed at the upper part of the module fixing plate (1) and is used to drive the upper synchronous pulley to rotate; The horizontal movement component includes a horizontal movement support plate (5), a horizontal movement linear guide rail component (6), a mixing rack (7), a reaction cup support (8), a reaction cup seat (9), a mixing gear (10), a horizontal movement motor (11), and a horizontal movement driving rod (12); the horizontal movement support plate (5) is fixedly connected to the slider of the lifting linear guide rail component (2); the guide rail of the horizontal movement linear guide rail component (6) is arranged horizontally, and the mixing rack (7) is arranged parallel above the guide rail of the horizontal movement linear guide rail component (6); the reaction cup support (8) is fixedly connected to the slider of the horizontal movement linear guide rail component (6); a vertical through hole is provided on the reaction cup support (8), and the reaction cup seat (9) is rotatably connected to the through hole through a bearing sleeved on the lower part; the mixing gear (10) is fixed at the bottom end of the reaction cup seat (9) and meshes with the mixing rack (7); the output shaft of the horizontal movement motor (11) faces vertically upward and is fixedly connected to one end of the horizontal movement driving rod (12), a chute is provided along the length direction of the horizontal movement driving rod (12), and a vertical guide rod at the bottom of the reaction cup support (8) is inserted into the chute, and the rotation of the output shaft of the horizontal movement motor (11) drives the reaction cup seat (9) to slide horizontally.

2. The cup transfer module for a chemiluminescence detector according to claim 1, characterized in that, A first opto-coupler sensor (13) for detecting the height position of the horizontal movement component is provided on the side of the module fixing plate (1).

3. The cup transfer module for a chemiluminescence detector according to claim 1 is characterized in that, A second opto-coupler sensor (14) for detecting the rotation angle of the horizontal movement driving rod (12) is provided on the side of the output shaft of the horizontal movement motor (11).

4. The cup transfer module for a chemiluminescence detector according to claim 1, wherein A plurality of the through holes are provided on the reaction cup support (8), and each through hole is connected to one reaction cup seat (9).

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