A water-in-oil structured multi-phase liquid bridge electrode device and its usage method

Abstract

The present invention belongs to the technical field of bioelectric stimulation application, and discloses an oil-in-liquid structure multiphase liquid bridge electrode device and a using method thereof. The oil-in-liquid structure multiphase liquid bridge electrode device includes a concentric tube body, which is an outer tube body and an inner tube body arranged coaxially. A first liquid storage cavity is formed inside the inner tube body, and a second liquid storage cavity is formed between the inner wall of the outer tube body and the outer wall of the inner tube body. A semi-circular covering part is arranged at the top of the first liquid storage cavity, and a semi-annular covering part is arranged at the top of the second liquid storage cavity. The outer periphery of the semi-annular covering part is connected to the peripheral edge of the upper port of the outer tube body, and the inner periphery of the semi-annular covering part is connected to the peripheral edge of the upper port of the inner tube body. This method uses a multiphase fluid liquid bridge to stimulate biological tissues. The electrode and the biological nerve tissue are not in direct contact, and no mechanical damage will be generated.

Description

Technical Field

[0001] This application belongs to the technical field of bioelectrical stimulation application, and relates to a water-in-oil structured multiphase liquid bridge electrode device and a method for using the same. Background Art

[0002] Bioelectrical stimulation is a way to regulate the potential of organisms or stimulate the nerves of organisms through electrodes to treat various neurological diseases or defects, such as: hemiplegia treatment, epilepsy treatment, motor neuron paralysis treatment, spinal cord injury treatment, etc. Among them, the most common instruments for using electrical stimulation to achieve adjuvant treatment include cochlear implants, cardiac pacemakers, suction aids, retinal nerve prostheses, motion boosters, etc.

[0003] In traditional electrical stimulation methods, when applying electrical stimulation, first, the signal is modulated into the required waveform, and then the signal is amplified by an amplification control circuit and input to the electrical stimulation electrode, so as to conduct electrical stimulation experiments on biological tissues, etc.

[0004] Most commonly used electrodes are made of conductive metals, and they inevitably have the following disadvantages:

[0005] 1) Due to the use of metal materials, the mechanical and biocompatibility with biological tissues is poor;

[0006] 2) Metal materials have a certain stiffness and cannot be well fixed to biological tissues without moving, and cannot ensure close electrical contact with nerves;

[0007] 3) Long-term corrosion of metal materials by biological tissues will cause immune reactions or mechanical damage to biological tissues;

[0008] 4) When metal materials penetrate into biological tissues, they will cause frictional damage to biological tissues, which has a greater impact on the application of electrical stimulation. Summary of the Invention

[0009] In view of this, the purpose of the present invention is to provide a water-in-oil structured multiphase liquid bridge electrode device and a method for using the same. The water-in-oil structured multiphase liquid bridge electrode device realizes electrical stimulation of the object to be treated by forming a water-in-oil structured multiphase liquid bridge, will not cause mechanical damage to the object to be treated, has stronger adaptability to the object to be treated, and can achieve stable and continuous electrical stimulation.

[0010] The present invention provides a water-in-oil structured multiphase liquid bridge electrode device, including:

[0011] The tube body, the tube body is a concentric tube, including an outer tube body and an inner tube body arranged coaxially. The outer tube body is sleeved outside the inner tube body. A first liquid storage cavity is formed inside the inner tube body, and a second liquid storage cavity is formed between the inner wall of the outer tube body and the outer wall of the inner tube body. A semi-circular covering part is arranged at the top of the first liquid storage cavity, and a semi-annular covering part is arranged at the top of the second liquid storage cavity. The outer periphery of the semi-annular covering part is connected to the peripheral edge of the upper port of the outer tube body, and the inner periphery of the semi-annular covering part is connected to the peripheral edge of the upper port of the inner tube body; in addition, a hydrophilic and lipophilic coating is applied to the lower ends of the inner and outer tube bodies.

[0012] An aqueous conductive liquid, which is used to transfer charges;

[0013] An oil-phase liquid;

[0014] An injection device, which is used to inject the aqueous conductive liquid and the oil-phase liquid into the first liquid storage cavity and the second liquid storage cavity respectively, and form a driving force for the aqueous conductive liquid and the oil-phase liquid to move downward respectively to form an oil-in-water structured multi-phase liquid bridge between the lower port of the tube body and the object to be treated.

[0015] Furthermore, the inner surface of the injection needle of the injection device is modified with polyethylenedioxythiophene material (PEDOT) to improve the charge injection ability.

[0016] Furthermore, the tube body is a silica gel tube, and the tube body is obtained by 3D printing.

[0017] Furthermore, both the outer tube body and the inner tube body are cylindrical hollow tube bodies.

[0018] Furthermore, the aqueous conductive liquid is an ionic aqueous solution.

[0019] Furthermore, the injection device includes a first micro-injection pump for injecting the oil-phase liquid and a second micro-injection pump for injecting the aqueous conductive liquid.

[0020] The present invention also provides a method for using the above-mentioned oil-in-water structured multi-phase liquid bridge electrode device, including the following steps:

[0021] S1. Vertically fix the tube body above the object to be treated, and the distance between the lower port of the tube body and the object to be treated is a preset value;

[0022] S2. Use the injection device to first inject the oil-phase liquid into the second liquid storage cavity until a preset amount is reached and then stop injecting;

[0023] S3. Use the injection device to inject the aqueous conductive liquid into the first liquid storage cavity again, so as to form a water-in-oil structured multiphase liquid bridge between the lower port of the tube body and the object to be treated;

[0024] S4. Use the water-in-oil structured multiphase liquid bridge to complete the treatment of the object to be treated.

[0025] Further, in the above-mentioned usage method, the dosage of the oil-phase liquid is preset according to the distance between the lower port of the tube body and the object to be treated.

[0026] Further, in the above-mentioned usage method, the treatment is to apply an electric current to the injection needle to achieve electrical stimulation.

[0027] Compared with the prior art, the present application has the following beneficial effects:

[0028] 1. The water-in-oil structured multiphase liquid bridge electrode device provided by the present application realizes electrical stimulation of the object to be treated through the water-in-oil structured multiphase fluid liquid bridge. The tube body in the device is not in direct contact with the object to be treated, and no mechanical damage will be caused; for the displacement of the object to be treated during movement, it has partial self-adaptability; the adhesion force of the liquid droplets can relatively stably connect the upper and lower interfaces, and continuous and stable electrical stimulation of the object to be treated can be realized.

[0029] 2. In the water-in-oil structured multiphase liquid bridge electrode device provided by the present application, the structure of the concentric tube makes it easier to control the ratio of the oil and water phases in the injection of the multiphase flow liquid bridge, and it has better adaptability to the application occasions. On the one hand, it has better adaptability to specific electrical stimulation points. For example, in some specific electrical stimulation experiments, specific points need to be stimulated, and these points are of different sizes. At this time, the ratio of the oil and water phases can be controlled to adapt; on the other hand, it has better adaptability to the distance from the object to be treated. For example, the device can be adapted to application occasions with different distance requirements (here, the distance refers to the distance between the bottom of the tube body and the object to be treated) by controlling the oil-phase liquid in the second liquid storage cavity.

[0030] 3. The technical solution provided by the present application has the ability of ion implantation. At the same time, its electrode impedance is relatively small due to the large electrode area. In addition, the transfer of the electron-ion charge conversion to the tube body in the present application is also beneficial to reducing the harm of the interfacial reaction to the object to be treated (such as biological tissue), and it has good biocompatibility.

[0031] 4. The inner surface of the injection needle modified with poly(3,4-ethylenedioxythiophene) (PEDOT) provided by the present application has a large specific surface area, stronger ion implantation ability and lower electrode impedance.

[0032] 5. Since the electrical stimulation in this application is achieved through the aqueous conductive liquid in the multiphase liquid bridge, drugs can be added to the aqueous conductive liquid, and then the aqueous conductive liquid containing the drugs can be continuously injected to promote drug absorption, and timely replenishment can be achieved after the drugs are absorbed. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] To more clearly illustrate the technical solutions of the embodiments of this application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can also be obtained based on these drawings without creative efforts.

[0034] Figure 1 Schematic diagram of the tube structure in the water-in-oil structure multiphase liquid bridge electrode device provided by the embodiment of the present invention;

[0035] Figure 2 Schematic diagrams of the states at each stage during the formation of the multiphase flow liquid bridge when the water-in-oil structure multiphase liquid bridge electrode device provided by the embodiment of the present invention is in use. Among them, Figure a shows the schematic diagram of the oil phase entering to form the oil phase liquid bridge, and Figure b shows the schematic diagram of the water phase entering to form the multiphase liquid bridge;

[0036] Figure 3 Basic schematic diagram of the liquid bridge bonding the upper and lower interfaces;

[0037] Figure 4 Schematic diagram of the flexible and adaptive deformation of the liquid bridge when the distance between the upper and lower interfaces moves slightly;

[0038] Figure 5a Schematic diagram of the structure of a conventional electrode;

[0039] Figure 5b For Figure 5a Enlarged view of part A in

[0040] Figure 5c Schematic diagram of the formation of the multiphase liquid bridge when the multiphase liquid bridge electrode device provided by the embodiment of this application is in use;

[0041] Figure 5d For Figure 5c Enlarged view of part B in

[0042] Figure 6 Simulation result diagram of the formation process of the multiphase flow liquid bridge in Embodiment 2 of this application;

[0043] Figure 7 Schematic diagram of the principle analysis of the maintenance of the stable state after the formation of the multiphase fluid liquid bridge structure in Embodiment 2 of this application;

[0044] Reference numerals: 1, inner tube body; 2, outer tube body; 3, first liquid storage cavity; 4, second liquid storage cavity; 5, semi-circular covering portion; 6, semi-annular covering portion; 7, conventional electrode electrode region; 8, conventional electrode region to be modulated; 9, electrode region of the present application; 10, region to be modulated of the present application; 11, biological tissue; 12, hydrophilic and lipophilic coating. Detailed implementation manners

[0045] To make the objectives, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Apparently, the described embodiments are some, but not all, of the embodiments of the present application. The components of the embodiments of the present application described and illustrated herein usually can be arranged and designed in various different configurations.

[0046] Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the present application claimed, but merely represents selected embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without creative efforts shall fall within the scope of protection of the present application.

[0047] It should be noted that similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0048] In the description of the embodiments of the present application, it should be noted that if terms such as "upper", "lower", "inner", "outer", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship when the product of this application is usually placed, it is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to the present application. In addition, terms such as "first", "second", etc. are only used for distinguishing descriptions and cannot be understood as indicating or implying relative importance.

[0049] In the description of the embodiments of the present application, it should also be noted that unless otherwise clearly specified and limited, if terms such as "set", "connected", "connected to" are understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific situations.

[0050] This embodiment provides a water-in-oil structured multi-phase liquid bridge electrode device, which includes a tube body. The tube body is a concentric tube, and its structural schematic diagram is as shown in Figure 1 As shown, the tube body includes an inner tube body 1 and an outer tube body 2 arranged coaxially. Both the inner tube body 1 and the outer tube body 2 are cylindrical hollow tube bodies, and their cross-sections are annular. The outer tube body 2 is sleeved outside the inner tube body 1. A first liquid storage cavity 3 is formed inside the inner tube body 1, and a second liquid storage cavity 4 is formed between the inner wall of the outer tube body 2 and the outer wall of the inner tube body 1. A semi-circular covering part 5 is arranged at the top of the first liquid storage cavity 3, and a semi-annular covering part 6 is arranged at the top of the second liquid storage cavity 4. The outer periphery of the semi-annular covering part 6 is connected to the peripheral edge of the upper port of the outer tube body 2, and the inner periphery of the semi-annular covering part 6 is connected to the peripheral edge of the upper port of the inner tube body 1. In the embodiment of the present application, the tube body is a silica gel tube. The lengths of the inner tube body 1 and the outer tube body 2 of the silica gel tube are 6 mm, the inner diameter of the inner tube body 1 is 0.3 mm, the outer diameter is 0.8 mm, the inner diameter of the outer tube body 2 is 1.2 mm, and the outer diameter is 1.5 mm. It is obtained by 3D printing. The silica gel tube has hydrophobic and lipophilic properties. In order to achieve better results, in the embodiment of the present application, polyvinylpyrrolidone (PVP) is configured into an aqueous solution to perform hydrophilic coating modification on the lower surface of the silicone rubber treated with a silane coupling agent, that is, there is a hydrophilic and lipophilic layer 12 with special hydrophilic treatment at the bottoms of the inner tube body 1 and the outer tube body 2.

[0051] The electrode device provided by the embodiment of the present invention further includes an aqueous conductive liquid, an oil-phase liquid, and an injection device. Among them, the injection device is used to inject the aqueous conductive liquid and the oil-phase liquid into the first liquid storage cavity 3 and the second liquid storage cavity 4 respectively, and form a driving force for the aqueous conductive liquid and the oil-phase liquid to move downward respectively to form a water-in-oil structured multi-phase liquid bridge between the lower port of the tube body and the object to be treated. Specifically, the injection device in the embodiment of the present application is two micro-injection pumps, including a first micro-injection pump for injecting the oil-phase liquid and a second micro-injection pump for injecting the aqueous conductive liquid.

[0052] In the embodiment of the present application, the object to be treated is selected to be a biological tissue 11.

[0053] The embodiment of the present application provides a method for using a water-in-oil structured multi-phase liquid bridge electrode device. Specifically, when performing bioelectrical stimulation, it includes the following steps:

[0054] S1. Fix the tube body above the object to be treated. The distance between the tube body and the object to be treated depends on the application scenario and is a preset value;

[0055] S2. First, use the first micro-injection pump to inject the oil-phase liquid into the second liquid storage cavity 4. As the injection progresses, an oily liquid bridge is gradually formed between the lower part of the outer tube body 2 and the object to be treated, as shown in Figure 2 a, and then stop injecting the oil-phase;

[0056] S3. Then, use the second micro-injection pump to inject the aqueous conductive liquid containing the drug into the inner tube body 1. Since oil and water are immiscible, the aqueous conductive liquid will form a new aqueous conductive liquid bridge containing the drug in the middle of the oil-phase liquid bridge. This liquid bridge expands continuously with the increase of the injection volume of the aqueous conductive liquid, forming a path for electric charges, and thus the water-in-oil multi-phase liquid bridge electrode is formed, as specifically shown in Figure 2 as shown in b;

[0057] S4. Utilize the multi-phase liquid bridge electrode obtained in step S3 to apply electrical stimulation or drug-assisted electrical stimulation by electrifying the metal needle of the syringe. In this step, the absorption of the drug by the biological tissue can be maintained through the continuously increasing inner drug liquid bridge.

[0058] It should be noted here that in the water-in-oil structure, the outer "oil" is an oily liquid harmless to organisms, including vegetable oils and animal oils, and this application does not make any limitations in this regard. The middle water is an ion aqueous solution with conductivity, including physiological saline, etc., and this application does not make any limitations in this regard.

[0059] In the embodiment of this application, a flexible connection is achieved between the tube body and the object to be processed through a water-in-oil multi-phase liquid bridge structure. The water-in-oil structure can transmit electric charges through the middle aqueous conductive liquid (ion solution) to apply electrical stimulation. After the liquid bridge is formed, due to the surface tension of the liquid bridge, the liquid bridge can stably connect the tube body and the object to be processed by using the adhesion of the liquid droplets, thereby ensuring the stability of the electrical stimulation. Combining Figure 3 with the schematic diagram, the principle is elaborated as follows:

[0060] As Figure 3 shown is the stable state of the liquid bridge between the upper and lower interfaces. According to Young's equation, when the liquid bridge is in a stable state, it is mainly affected by the gas-liquid interface tension (γ gl ), the solid-liquid interface tension (γ ls ) and the gas-solid interface tension (γ gs ). Among them, the gas-solid interface tension reaches equilibrium with the horizontal components of the solid-liquid interface tension and the gas-liquid interface tension, and the vertical component of the interface tension on the gas-liquid surface provides an upward adhesion force to bond the upper and lower interfaces. Since a fluid liquid bridge is used, for the displacement during the movement of the lower interface, it has partial self-adaptability. The liquid bridge can flexibly and adaptively deform with the slight movement of the upper and lower interfaces. The deformation schematic diagram is as shown in Figure 4 . In this way, even when the distance between the upper and lower interfaces changes slightly due to the movement of the lower interface, the fluid liquid bridge can adapt to this unstable change and maintain the stability of charge transfer.

[0061] Implementing electrical stimulation through the multi-phase fluid liquid bridge transfers the electron-ion charge conversion and transportation that originally occurred on the surface of the object to be processed to the inner electrode of the pipeline. Taking the biological tissue 11 as the object to be processed, inFigure 5a and Figure 5b In the conventional electrode shown in Figure 5b , the contact area between the electrode region 7 (electronic charge) and the region 8 to be modulated (ionic charge) is small, so the charge injection ability during electrical stimulation is poor; in Figure 5c and Figure 5d In the device of the present application shown in Figure 5d , the contact area between the electrode region 9 (electronic charge) and the aqueous phase region 10 (ionic charge) is large, and the charge injection ability is strong. Also, since both ends of the liquid storage cavity are connected to the outside, the large area and openness of the electrode inside the inner tube body 1 greatly improve its ion injection ability. At the same time, its electrode impedance is relatively small due to the larger electrode area. Moreover, transferring the electron-ion charge conversion to the inside of the inner tube body 1 is also beneficial to reducing the damage of the interfacial reaction to the biological tissue 11 and improving the biocompatibility of the electrode.

[0062] Regarding the process of forming a multiphase liquid bridge in the entire concentric tube structure, we carried out corresponding simulations based on the COMSOL simulation software. The simulation parameters are as follows: Set the radius of the internal aqueous phase channel to 0.3 mm, set the radius of the external oil phase to 0.6 mm, set the default oil phase and aqueous phase parameters in COSMSOL to be used, set the injection speed of the oil phase to be 2 mm / s when injecting first, and the injection time to be 2 s; set the aqueous phase to be injected later, with an injection speed of 2 mm / s and an injection time of 1 s. The simulation results are as Figure 6 shown. Figure 6 The light-colored part in Figure 6 is the oil phase, and the dark-colored part is the aqueous phase. Figure 6 a is the initial state, and neither oil nor water is injected; with the injection, an oily liquid bridge gradually forms in the structure below the outer concentric tube, as shown in Figure 6 b - c; then, stop injecting the oil phase, and continuously inject the drug (conductive liquid) into the inner concentric tube, and gradually form an increasing inner drug liquid bridge to maintain the absorption of the drug by the biological tissue, as shown in Figure 6 c - d. This simulation is completely consistent with our previous analysis.

[0063] It should be noted here that using a micro syringe is only one implementation manner of the present application, and it can also be other syringes or samplers, and the present application does not make any limitations in this regard. The amounts of the aqueous phase conductive liquid and the oil phase conductive liquid extracted should depend on the specific size of the tube body. The above extraction amounts are only one implementation manner of the present application, and the present application does not make any limitations in this regard.

[0064] The principle for maintaining stability after the formation of the multiphase fluid liquid bridge structure of this electrode is explained as follows:

[0065] As Figure 7 shown, the liquid column in the silica gel tube will generate a hydraulic pressure difference on the lower oil phase (the pressure of the aqueous phase on the lower part is P 重 = ρ 水 gh, where ρ 水is the density of the aqueous phase in the liquid column, g is the gravitational constant, and h is the height of the liquid column; for the oil phase, the pressure on the lower part is P’ 重 = ρ 油 gh, where ρ 油 is the density of the oil phase in the liquid column), thus pressing the aqueous solution into the oil phase to form a liquid bridge structure.

[0066] Combined with the Laplace equation, the total downward pressure P0 of the aqueous phase is

[0067] P0 = P 重 + P2 = ρ 水 gh + γ 水 / R (1)

[0068] where, P 重 is the gravity caused by the aqueous phase in the inner tube, P2 is the surface tension at the inlet end of the aqueous phase in the inner tube, γ 水 is the surface tension coefficient of water and air, R is the curvature radius of the upper liquid column, and from the geometric relationship, R = L / (2cosα), so R is mainly affected by the hydrophilicity of the silica gel tube (expressed as the contact angle α) and the diameter L of the upper inner tube;

[0069] The total downward pressure P‘0 of the oil phase is

[0070] P‘0 = P’ 重 + P’2 = ρ 油 gh + γ 油 / R1 (2)

[0071] where, P’ 重 is the gravity caused by the oil phase in the outer tube, P’2 is the surface tension at the inlet end of the oil phase in the outer tube, γ 油 is the surface tension coefficient of oil and air, R1 is the curvature radius of the upper liquid column, and from the geometric relationship, R1 = L‘ / (2cosθ), so R1 is mainly affected by the lipophilicity of the silica gel tube (expressed as the contact angle θ) and the diameter L‘ of the upper outer tube. From equations (1) and (2), it can be seen that as the aqueous liquid column enters the lower oil phase, the height of the aqueous liquid column decreases, P 重 becomes smaller, and the value of R is relatively large and basically remains unchanged, so P0 becomes smaller;

[0072] When the aqueous phase enters the lower oil phase, due to the immiscibility of oil and water, a water-in-oil structure will be formed between the silica gel tube and the biological nerve tissue. In this liquid bridge structure, an upward Laplace surface tension will be generated (and is mainly affected by it), and its total upward pressure is

[0073] P1 = γ 油水 / R2 (3)

[0074] P’1 = γ 油 / R3 (4)

[0075] Among them, P1 is the upward pressure generated by the aqueous liquid bridge at the lower end after injecting the aqueous phase due to the interfacial tension, P’1 is the upward pressure generated by the oil phase at the lower end due to the interfacial tension, and γ 油水 is the surface tension coefficient of the oil-water phase, γ 油 is the surface tension coefficient of the oil and air, R2 is the radius of curvature of the aqueous liquid bridge at the lower end, R3 is the radius of curvature of the oil phase liquid bridge at the lower end. From the geometric relationship, it can be known that R2 = S / (2cosβ) and therefore R2 is mainly affected by the hydrophilicity of the lower bottom surface of the silica gel tube (manifested as the contact angle β) and the distance S between the silica gel tube and the surface of the biological tissue. R3 is mainly affected by the lipophilicity of the lower bottom surface of the silica gel tube (manifested as the contact angle ).) and the distance S between the silica gel tube and the surface of the biological tissue. As the aqueous liquid column enters the lower oil phase, since R2 and R3 remain basically unchanged, P1 and P’1 also remain basically unchanged.

[0076] As P0 and P‘0 become smaller while P1 and P’1 remain unchanged, the two finally reach a force balance, and the overall structure enters a stable state.

[0077] The above is only the preferred embodiment of the present application and is not used to limit the present application. For those skilled in the art, various changes and modifications can be made to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included within the protection scope of the present application.

Claims

1. A water-in-oil structured multi-phase liquid bridge electrode device, characterized in that, Comprising: A tube body, the tube body being a concentric tube, including an outer tube body and an inner tube body arranged coaxially. The outer tube body is sleeved outside the inner tube body. A first liquid storage cavity is formed inside the inner tube body. A second liquid storage cavity is formed between the inner wall of the outer tube body and the outer wall of the inner tube body. A semi-circular covering portion is provided at the top of the first liquid storage cavity. A semi-annular covering portion is provided at the top of the second liquid storage cavity. The outer periphery of the semi-annular covering portion is connected to the peripheral edge of the upper port of the outer tube body. The inner periphery of the semi-annular covering portion is connected to the peripheral edge of the upper port of the inner tube body; An aqueous conductive liquid, which is used to transfer charges; An oil-phase liquid; An injection device, which is used to inject the aqueous conductive liquid and the oil-phase liquid into the first liquid storage cavity and the second liquid storage cavity respectively, and form a driving force for the aqueous conductive liquid and the oil-phase liquid to move downward respectively to form an oil-in-water structured multiphase liquid bridge between the lower port of the tube body and the object to be treated.

2. The water-in-oil structured multi-phase liquid bridge electrode device according to claim 1, wherein The tube body is a silicone tube and is obtained by 3D printing.

3. The water-in-oil structured multiphase liquid bridge electrode device according to claim 1, wherein Both the outer tube body and the inner tube body are cylindrical hollow tube bodies.

4. The water-in-oil structured multiphase liquid bridge electrode device according to claim 1, characterized in that The aqueous conductive liquid is an ionic aqueous solution.

5. The water-in-oil structured multi-phase liquid bridge electrode device according to claim 1, wherein The aqueous conductive liquid is an ionic aqueous solution containing drugs.

6. The water-in-oil structure multi-phase liquid bridge electrode device according to claim 1, wherein The injection device includes a first micro-injection pump for injecting the oil-phase liquid and a second micro-injection pump for injecting the aqueous conductive liquid.

7. The water-in-oil structure multiphase liquid bridge electrode device according to claim 1, characterized in that, The inner surface of the injection needle of the injection device is modified with polyethylenedioxythiophene material.

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