A blood analyzer and a detection method thereof

Abstract

The application discloses a blood analyzer and a detection method thereof. The blood analyzer comprises a mode selection module, a blood routine detection module, a specific protein detection module and a control module. The mode selection module is used for selecting one detection mode from multiple detection modes of the blood analyzer, and the multiple detection modes comprise a specific protein single detection mode and a detection mode containing blood routine detection. The blood routine detection module is used for performing blood routine detection on a blood sample. The specific protein detection module is used for performing specific protein detection on the blood sample. When the mode selection module switches the specific protein single detection mode to the detection mode containing blood routine detection, the control module adopts a first cleaning mode to clean a reaction pool corresponding to the specific protein single detection mode of the blood routine detection module. In this way, the occurrence of hole blockage can be prevented, the detection accuracy of the blood analyzer is improved, and the blood analyzer is convenient to use.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of blood detection, in particular to a blood analyzer and a detection method thereof. BACKGROUND

[0002] With the development of academic research and clinical examination, blood routine and SAA (serum amyloid A protein) or CRP (C-reactive protein) combined detection by a blood analyzer has high practical value, which can greatly help patients in the detection and treatment of infection types.

[0003] The existing blood routine and specific protein combined detection integrated machine is prone to hole blockage, causing inconvenience to users. SUMMARY

[0004] To solve the above problems, the present application provides a blood analyzer and a detection method thereof, which adopts a first cleaning mode to clean the reaction pool corresponding to the blood routine detection module and the specific protein single detection mode, thereby preventing hole blockage.

[0005] One of the technical solutions adopted by the present application is to provide a blood analyzer, which comprises a mode selection module, a blood routine detection module, a specific protein detection module and a control module, the mode selection module is used to select a detection mode from a plurality of detection modes of the blood analyzer, the plurality of detection modes include a specific protein single detection mode and a detection mode containing blood routine detection; the blood routine detection module is used to perform blood routine detection on a blood sample; the specific protein detection module is used to perform specific protein detection on the blood sample.

[0006] When the mode selection module switches the specific protein single detection mode to the detection mode containing blood routine detection, the control module adopts a first cleaning mode to clean the reaction pool corresponding to the blood routine detection module and the specific protein single detection mode.

[0007] The reaction pool corresponding to the blood routine detection module and the specific protein single detection mode includes a WBC reaction pool and an RBC reaction pool, when the mode selection module switches the specific protein single detection mode to the detection mode containing blood routine detection, the control module adopts a first cleaning mode to clean the WBC reaction pool and / or the RBC reaction pool.

[0008] The gem holes of the WBC reaction pool and / or the gem holes of the RBC reaction pool are at least once burnt and backflushed when the control module adopts the first cleaning mode to clean the WBC reaction pool and / or the RBC reaction pool; and / or, the WBC reaction pool and / or the RBC reaction pool are cleaned by cleaning liquid.

[0009] The control module is configured to control the specific protein detection module to detect when the mode selection module selects the specific protein single detection mode.

[0010] The control module adopts the first cleaning mode to clean the WBC reaction pool and / or the RBC reaction pool when the control module determines that the detection times of the specific protein detection module is an integer multiple of the preset number.

[0011] The preset number is 1, and the control module adopts the first cleaning mode to clean the WBC reaction pool and / or the RBC reaction pool after each detection is completed.

[0012] The preset number is greater than 1, and the control module adopts the second cleaning mode to clean the WBC reaction pool and / or the RBC reaction pool when the control module determines that the detection times is not an integer multiple of the preset number.

[0013] Another technical solution adopted by the present application is to provide a detection method of a blood analyzer, applied to the blood analyzer described above, and the detection method comprises:

[0014] The blood analyzer is provided with multiple detection modes, including a specific protein single detection mode and a blood routine detection mode.

[0015] The control module adopts the first cleaning mode to clean the blood routine detection module and the reaction pool corresponding to the specific protein single detection mode when the mode selection module switches the specific protein single detection mode to the blood routine detection mode.

[0016] The reaction pool corresponding to the blood routine detection module and the specific protein single detection mode includes a WBC reaction pool and an RBC reaction pool, and the step of the control module adopting the first cleaning mode to clean the reaction pool corresponding to the blood routine detection module and the specific protein single detection mode includes:

[0017] The gem holes of the WBC reaction pool and / or the gem holes of the RBC reaction pool are at least once burnt and backflushed;

[0018] And / or, the WBC reaction pool and / or the RBC reaction pool are cleaned by a cleaning solution.

[0019] The detection method further comprises:

[0020] When the mode selection module selects the specific protein single detection mode, the control module controls the specific protein detection module to perform detection.

[0021] The control module determines whether the detection times of the specific protein detection module is an integer multiple of the preset number of times.

[0022] When the control module determines that the detection times is an integer multiple of the preset number of times, the control module adopts a first cleaning mode to clean the WBC reaction pool and / or the RBC reaction pool.

[0023] The control module controls the specific protein detection module to perform detection, which comprises:

[0024] The control module controls the sampling module of the blood analyzer to suck the blood sample and distribute the blood sample to the specific protein reaction pool of the specific protein detection module.

[0025] The control module adds reagent to the specific protein reaction pool and performs detection to obtain a detection result.

[0026] The control module controls the sampling module to distribute the blood sample to the WBC reaction pool to dilute the blood sample.

[0027] The control module controls the sampling module to add part of the diluted sample of the WBC reaction pool to the RBC reaction pool of the blood routine detection module to calculate an HCT value.

[0028] The control module corrects the detection result based on the HCT value.

[0029] The blood analyzer of the application comprises a mode selection module, a routine blood test module, a specific protein test module and a control module, the mode selection module is used to select one detection mode from multiple detection modes of the blood analyzer, the multiple detection modes comprise a specific protein single detection mode and a detection mode containing routine blood test; when the mode selection module switches the specific protein single detection mode to the detection mode containing routine blood test, the control module adopts a first cleaning mode to clean the reaction pool corresponding to the routine blood test module and the specific protein single detection mode. The application adopts the first cleaning mode to clean the reaction pool corresponding to the routine blood test module and the specific protein single detection mode, which can unblock the reaction pool corresponding to the routine blood test module and the specific protein single detection mode, prevent the occurrence of hole blocking, improve the detection accuracy of the blood analyzer, and make the user convenient to use. BRIEF DESCRIPTION OF DRAWINGS

[0030] In order to more clearly illustrate the technical solutions in the embodiments of the application, the drawings needed to be used in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative labor. Among them:

[0031] Figure 1 is a structural schematic diagram of the first embodiment of the blood analyzer of the application;

[0032] Figure 2 is a flowchart of the first embodiment of the detection method of the blood analyzer of the application;

[0033] Figure 3 is a flowchart of the second embodiment of the detection method of the blood analyzer of the application;

[0034] Figure 4 is a flowchart of the third embodiment of the detection method of the blood analyzer of the application;

[0035] Figure 5 is Figure 3 the first embodiment of step S301 in DETAILED DESCRIPTION

[0036] With reference to the drawings, the technical solutions in the embodiments of the present application will be clearly and completely described below. It can be understood that the specific embodiments described here are only used to explain the present application, but not to limit the present application. In addition, it should be noted that, in order to facilitate description, only the parts related to the present application are shown in the drawings, rather than all the structures. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of the present application.

[0037] The terms "first", "second", and the like in the present application are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device including a series of steps or units is not limited to the listed steps or units, but can optionally include steps or units not listed, or can optionally include other steps or units inherent to the process, method, product or device.

[0038] In this document, the term "embodiment" means that the specific features, structures or characteristics described in connection with the embodiment can be included in at least one embodiment of the present application. The phrase appears at various places in the specification does not necessarily all refer to the same embodiment, nor is it necessarily mutually exclusive of other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0039] Please refer to Figure 1 shown, Figure 1 is a structural schematic diagram of a first embodiment of a blood analyzer of the present application. The blood analyzer 10 of the present application includes a mode selection module 11, a specific protein detection module 12, a blood routine detection module 13 and a control module 14.

[0040] Among them, the specific protein detection module 12 is used for specific protein detection of whole blood sample, and the blood routine detection module 13 is used for blood routine detection of whole blood sample; the control module 14 can be connected with the mode selection module 11, the specific protein detection module 12 and the blood routine detection module 13 respectively. In other embodiments, the specific protein detection module 12 can detect other blood samples, such as serum samples, etc.

[0041] The blood routine test includes WBC (White Blood Cell) test, HGB (Hemoglobin) test, RBC (red blood cell) test, DIFF (differential) test or RET (reticulocyte) test. The specific protein includes one of SAA, CRP, TRF (transferrin), Hs-CRP (high-sensitivity C-reactive protein), PCT (procalcitonin) and D-Dimer (D-dimer).

[0042] The mode selection module 11 is configured to select one of a plurality of detection modes of the blood analyzer 10. Alternatively, the mode selection module 11 is configured to pre-set the plurality of detection modes of the blood analyzer 10.

[0043] Specifically, the plurality of detection modes of the blood analyzer 10 includes a specific protein-only detection mode and a blood routine test-included detection mode. The specific protein-only detection mode means that only the specific protein parameter and the HCT test result (i.e. HCT value) are outputted. The specific protein-only detection mode can be SAA-only detection mode, CRP-only detection mode, SAA+CRP-only detection mode, TRF-only detection mode, Hs-CRP-only detection mode, PCT-only detection mode or D-Dimer-only detection mode.

[0044] When the mode selection module 11 selects the specific protein-only detection mode, the specific protein detection module 12 corresponding to the specific protein-only detection mode in the blood analyzer 10 is configured to detect the whole blood sample, i.e. the control module 14 is configured to control the specific protein detection module 12 to detect the whole blood sample. At this time, the WBC reaction cell 131 of the blood routine test module 13 is used as a dilution cell of the whole blood sample, and no hemolytic agent is added, which causes the WBC reaction cell 131 to be easily blocked, so that the blood analyzer 10 cannot be normally used. In addition, the RBC reaction cell 132 of the blood routine test module 13 is used to detect the diluted whole blood sample to calculate the HCT value. In order to ensure the accuracy of the HCT value, the RBC reaction cell 132 also needs to be cleaned.

[0045] Therefore, when the mode selection module 11 switches the specific protein-only detection mode to the blood routine test-included detection mode, the control module 14 uses the first cleaning mode to clean the reaction cell corresponding to the specific protein-only detection mode in the blood routine test module 13.

[0046] The detection mode with blood routine detection indicates that the output result includes the measurement mode of total number of white blood cells, red blood cells, platelets, hemoglobin, etc. For example, the detection mode with blood routine detection is CBC (complete blood count) + Diff + CRP detection mode, CBC + Diff + SAA detection mode, CBC + Diff + SAA + CRP detection mode, CBC + SAA detection mode, CBC + CPR detection mode, or CBC + CPR + SAA detection mode, etc.

[0047] The reaction pool corresponding to the specific protein single detection mode of the blood routine detection module 13 includes a WBC reaction pool 131 and an RBC reaction pool 132. When the mode selection module 11 switches the specific protein single detection mode to the detection mode with blood routine detection, the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0048] In an embodiment, the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 to unblock the WBC reaction pool 131, prevent the WBC reaction pool 131 from being blocked, and improve the detection accuracy of the blood analyzer.

[0049] For example, the mode selection module 11 switches the CRP single detection mode to the blood routine detection mode, and the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 to unblock the WBC reaction pool 131. The blood analyzer 10 uses the WBC reaction pool 131 as a dilution pool for whole blood samples in the CRP single detection mode, which causes the WBC reaction pool 131 to be easily blocked. Therefore, when the mode selection module 11 switches the CRP single detection mode to the blood routine detection mode, the control module 14 needs to adopt the first cleaning mode to clean the WBC reaction pool 131 to unblock the WBC reaction pool 131.

[0050] In an embodiment, the control module 14 adopts the first cleaning mode to clean the RBC reaction pool 132 to unblock the RBC reaction pool 132, to ensure the accuracy of the HCT value, and improve the detection accuracy of the blood analyzer.

[0051] In an embodiment, the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 and the RBC reaction pool 132 to unblock the WBC reaction pool 131 and the RBC reaction pool 132, prevent the WBC reaction pool 131 from being blocked, ensure the accuracy of the HCT value, improve the detection accuracy of the blood analyzer, and make it convenient for users to use.

[0052] When the mode selection module 11 switches the specific protein single detection mode to the blood routine detection mode, the control module 14 adopts the first cleaning mode to clean the reaction pool corresponding to the specific protein single detection mode of the blood routine detection module 13, which can clean the reaction pool corresponding to the specific protein single detection mode of the blood routine detection module, prevent the hole from being blocked, improve the detection accuracy of the blood analyzer, and make the user convenient to use.

[0053] In an embodiment, when the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132, the gemstone hole of the WBC reaction pool 131 and / or the gemstone hole of the RBC reaction pool 132 is at least once burned and backflushed, for example, the gemstone hole of the WBC reaction pool 131 and / or the gemstone hole of the RBC reaction pool 132 is burned and backflushed multiple times, so as to clean the gemstone hole of the WBC reaction pool 131 and / or the gemstone hole of the RBC reaction pool 132.

[0054] In an embodiment, when the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132, the WBC reaction pool 131 and / or the RBC reaction pool 132 is cleaned by cleaning liquid (such as hemolytic agent), for example, the WBC reaction pool 131 and / or the RBC reaction pool 132 is cleaned by R1 reagent, so as to clean the gemstone hole of the WBC reaction pool 131 and / or the gemstone hole of the RBC reaction pool 132.

[0055] In other embodiments, the WBC reaction pool 131 and / or the RBC reaction pool 132 can be cleaned by cleaning liquid, and the gemstone hole of the WBC reaction pool 131 and / or the gemstone hole of the RBC reaction pool 132 is at least once burned and backflushed, so as to clean the WBC reaction pool 131 and / or the RBC reaction pool 132, and improve the cleaning effect of the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0056] In an embodiment, the blood analyzer 10 can include at least two specific protein detection modules 12, for example, the at least two specific protein detection modules 12 include SAA detection module and CRP detection module, that is, the blood analyzer 10 is a blood routine, SAA and CRP combined detection all-in-one machine.

[0057] When the mode selection module 11 selects the specific protein single detection mode, the specific protein detection module 12 corresponding to the specific protein single detection mode in the blood analyzer 10 performs detection, i.e., the control module 14 is configured to control the specific protein detection module 12 to perform detection. For example, when the mode selection module 11 selects the SAA single detection mode, the control module 14 is configured to control the specific protein detection module 12 (e.g., an SAA detection module) corresponding to the SAA single detection mode to perform detection on the whole blood sample; or, when the mode selection module 11 selects the CRP single detection mode, the control module 14 is configured to control the specific protein detection module 12 (e.g., a CRP detection module) corresponding to the CRP single detection mode to perform detection on the whole blood sample; or, when the mode selection module 11 selects the SAA+CRP single detection mode, the control module 14 is configured to control the specific protein detection module 12 (e.g., the SAA detection module and the CRP detection module) corresponding to the SAA+CRP single detection mode to perform detection on the whole blood sample.

[0058] When the specific protein detection module 12 performs detection, the control module 14 can count the number of detections of the specific protein detection module 12 in the specific protein single detection mode to obtain the number of detections of the specific protein detection module 12. The control module 14 is configured to compare the number of detections of the specific protein detection module 12 with a preset number to determine whether the number of detections is an integer multiple of the preset number; when the control module 14 determines that the number of detections of the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 is configured to adopt the first cleaning mode to clean the reaction pool of the blood routine detection module 13 corresponding to the specific protein single detection mode. The integer multiple is a positive integer greater than 0, for example, the integer multiple is 1, 2, 3, 4, 5, or 6.

[0059] Specifically, when the control module 14 determines that the number of detections of the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 is configured to adopt the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0060] For example, when the mode selection module 11 selects the CRP single detection mode as the specific protein single detection mode, the control module 14 counts the number of detections of the specific protein detection module 12 in the CRP single detection mode. When the control module 14 determines that the number of detections is an integer multiple of the preset number, the control module 14 is configured to adopt the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 of the blood routine detection module 13, which can unblock the WBC reaction pool 131 and / or the RBC reaction pool 132 to prevent the WBC reaction pool 131 and / or the RBC reaction pool 132 from being blocked, thereby improving the detection accuracy of the blood analyzer 10 and facilitating user use.

[0061] In this application, the blood analyzer 10 has multiple detection modes, all of which are measurement parameter modes. For example, if the mode selection module 11 selects the specific protein detection mode as the CRP detection mode, then the specific protein detection module 12 will perform CRP detection on the whole blood sample.

[0062] Optionally, the blood analyzer 10 of this application can be configured with a sample introduction mode. The sample introduction mode refers to the method by which the blood analyzer 10 draws whole blood samples from test tubes. The sample introduction modes include automatic sample introduction mode and open sample introduction mode. In automatic sample introduction mode, the sampler of the blood analyzer 10 pushes the test tube to draw the whole blood sample from the test tube into the blood analyzer 10. For example, if the user places a test tube rack on the blood analyzer 10, the blood analyzer 10 can continuously test whole blood samples from multiple test tubes on the test tube rack. In open sample introduction mode, the user places the test tube under the sampling needle of the blood analyzer 10, and the blood analyzer 10 draws and tests the whole blood sample from the test tube.

[0063] like Figure 1 As shown, the blood analyzer 10 also includes a sampling module 15 connected to the control module 14. The sampling module 15 is used to collect whole blood samples and distribute them to the specific protein detection module 12. The following describes in detail the detection steps of the specific protein detection module 12 on the whole blood sample when the specific protein detection mode is selected by the mode selection module 11:

[0064] The control module 14 controls the sampling module 15 of the blood analyzer 10 to draw whole blood samples and distribute them to the specific protein reaction chamber 121 of the specific protein detection module 12. Specifically, the control module 14 controls the sampling module 15 to move to a test tube to draw whole blood samples; the control module 14 controls the sampling module 15 to move to the specific protein reaction chamber 121 to distribute whole blood samples to the specific protein reaction chamber 121; and the control module 14 controls the sampling module 15 to perform cleaning.

[0065] The control module 14 adds reagents to the specific protein reaction chamber 121 and performs detection to obtain the detection results, which include specific protein parameters. Specifically, the control module 14 can control the sampling module 15 to draw reagents and inject them into the specific protein reaction chamber 121; the control module 14 also controls the sampling module 15 to perform cleaning. The whole blood sample and reagents in the specific protein reaction chamber 121 are mixed and reacted, and the blood analyzer 10 detects the liquid within the specific protein reaction chamber 121 to obtain the detection results.

[0066] The control module 14 controls the sampling module 15 to dispense the whole blood sample to the WBC reaction pool 131 for dilution of the whole blood sample. The control module 14 can control the sampling module 15 to dispense the whole blood sample to the WBC reaction pool 131 when the whole blood sample is dispensed to the specific protein reaction pool 121, and the WBC reaction pool 131 is used for one-time dilution of the whole blood sample to obtain a diluted sample of the WBC reaction pool 131.

[0067] The control module 14 controls the sampling module 15 to add part of the diluted sample of the WBC reaction pool 131 to the RBC reaction pool 132 of the blood routine detection module 13 to calculate the HCT value. After the sampling module 15 adds part of the diluted sample of the WBC reaction pool 131 to the RBC reaction pool 132, the RBC reaction pool 132 performs secondary dilution on the diluted sample, and the blood analyzer 10 detects the liquid in the RBC reaction pool 132 to obtain the HCT value.

[0068] The control module 14 corrects the detection result based on the HCT value. The control module 14 corrects the detection result by using the HCT value to make the corrected detection result more accurate.

[0069] The blood analyzer 10 of the present application uses the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 of the blood routine detection module 13 when the control module 14 determines that the detection times are an integer multiple of the preset number of times, which can unblock the WBC reaction pool 131 and / or the RBC reaction pool 132 to prevent the WBC reaction pool 131 and / or the RBC reaction pool 132 from being blocked, ensure the accuracy of the HCT value, ensure that the blood analyzer 10 can work normally, and improve the detection accuracy of the blood analyzer 10.

[0070] In an embodiment, the preset number of times is 1, and the control module 14 is configured to use the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 when the control module 14 determines that the detection times are an integer multiple of the preset number of times. Since any positive integer of detection times is an integer multiple of the preset number of times, the control module 14 is configured to use the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 after each detection, i.e., the control module 14 uses the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 after each detection of the specific protein detection module 12.

[0071] In an embodiment, the preset number of times is greater than 1, and when the control module 14 judges that the number of detection times is not an integer multiple of the preset number of times, the control module 14 is configured to use the second cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132. For example, the preset number of times is 3, and the control module 14 counts the number of detection times of the specific protein detection module 12 as 2, and then judges that the number of detection times is not an integer multiple of the preset number of times, and uses the second cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0072] When the control module 14 is configured to use the second cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132, the WBC reaction pool 131 and / or the RBC reaction pool 132 can be cleaned by diluent to avoid mutual contamination of multiple whole blood samples in the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0073] The blood analyzer 10 of the embodiment is in the specific protein single detection mode, and the number of detection times of the specific protein detection module 12 is an integer multiple of the preset number of times, and the control module 14 is configured to use the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132, which can unblock the WBC reaction pool 131 and / or the RBC reaction pool 132 to prevent the WBC reaction pool 131 and / or the RBC reaction pool 132 from being blocked, thereby improving the detection accuracy of the blood analyzer 10.

[0074] When the mode selection module 11 switches the specific protein single detection mode to the blood routine detection mode, the detection steps of the blood routine detection module 13 on the whole blood sample include:

[0075] The control module 14 controls the sampling module 15 of the blood analyzer 10 to suck the whole blood sample and distribute the whole blood sample to the WBC reaction pool 131 and / or the RBC reaction pool 132 of the blood routine detection module 13. Among them, the control module 14 controls the sampling module 15 to move to the test tube to suck the whole blood sample from the test tube; the control module 14 controls the sampling module 15 to move to the WBC reaction pool 131 and / or the RBC reaction pool 132 to distribute the whole blood sample to the WBC reaction pool 131 and / or the RBC reaction pool 132; the control module 14 controls the sampling module 15 to clean. The control module 14 detects the whole blood sample through the WBC reaction pool 131 and / or the RBC reaction pool 132 to realize the detection of the whole blood sample by the blood routine detection module 13.

[0076] Please refer to Figure 2 as shown, Figure 2 is a flowchart of the first embodiment of the detection method of the blood analyzer of the present application. The detection method of the embodiment is applied to the blood analyzer 10 described above, and the detection method includes the following steps:

[0077] S201: The blood analyzer 10 is provided with multiple detection modes, and the multiple detection modes include a specific protein single detection mode and a blood routine detection mode.

[0078] The multiple detection modes of the blood analyzer 10 include the specific protein single detection mode and the blood routine detection mode, and the specific protein single detection mode indicates a mode of outputting only specific protein parameters and HCT detection results. The specific protein single detection mode can be an SAA single detection mode, a CRP single detection mode, an SAA+CRP single detection mode, a TRF single detection mode, an Hs-CRP single detection mode, a PCT single detection mode, or a D-Dimer single detection mode.

[0079] S202: When the mode selection module 11 switches the specific protein single detection mode to the blood routine detection mode, the control module 14 adopts a first cleaning mode to clean the blood routine detection module 13 and the reaction pool corresponding to the specific protein single detection mode.

[0080] The blood routine detection mode indicates a mode of outputting results including the total number of white blood cells, red blood cells, platelets, hemoglobin, etc. For example, the blood routine detection mode can be a CBC(complete blood count)+Diff+CRP detection mode, a CBC+Diff+SAA detection mode, a CBC+Diff+SAA+CRP detection mode, a CBC+SAA detection mode, a CBC+CPR detection mode, or a CBC+CPR+SAA detection mode.

[0081] The reaction pool corresponding to the specific protein single detection mode of the blood routine detection module 13 includes a WBC reaction pool 131 and an RBC reaction pool 132. When the mode selection module 11 switches the specific protein single detection mode to the blood routine detection mode, the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0082] In an embodiment, the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 to unblock the WBC reaction pool 131, prevent the WBC reaction pool 131 from being blocked, and improve the detection accuracy of the blood analyzer.

[0083] For example, the mode selection module 11 switches the CRP single detection mode to the blood routine detection mode, and the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131, so as to unblock the WBC reaction pool 131. When the blood analyzer 10 uses the WBC reaction pool 131 as a dilution pool of the whole blood sample in the CRP single detection mode, the WBC reaction pool 131 is prone to be blocked. Therefore, when the mode selection module 11 switches the CRP single detection mode to the blood routine detection mode, the control module 14 needs to adopt the first cleaning mode to clean the WBC reaction pool 131, so as to unblock the WBC reaction pool 131.

[0084] In an embodiment, the control module 14 adopts the first cleaning mode to clean the RBC reaction pool 132, so as to unblock the RBC reaction pool 132, to ensure the accuracy of the HCT value and improve the detection accuracy of the blood analyzer.

[0085] In an embodiment, the control module 14 adopts the first cleaning mode to clean the WBC reaction pool 131 and the RBC reaction pool 132, so as to unblock the WBC reaction pool 131 and the RBC reaction pool 132, to prevent the WBC reaction pool 131 from being blocked and ensure the accuracy of the HCT value, improve the detection accuracy of the blood analyzer, and make the user convenient to use.

[0086] When the mode selection module 11 switches the specific protein single detection mode to the blood routine detection mode, the control module 14 adopts the first cleaning mode to clean the blood routine detection module 13 and the reaction pool corresponding to the specific protein single detection mode, so as to unblock the reaction pool corresponding to the blood routine detection module and the specific protein single detection mode, to prevent the reaction pool from being blocked, improve the detection accuracy of the blood analyzer, and make the user convenient to use.

[0087] Please refer to Figure 3 , Figure 3 is a flowchart of a second embodiment of the detection method of the blood analyzer of the present application. The detection method of the present embodiment comprises the following steps:

[0088] S301: When the mode selection module 11 selects the specific protein single detection mode, the control module 14 controls the specific protein detection module 12 to perform detection.

[0089] When the mode selection module 11 selects the specific protein single detection mode, the specific protein detection module 12 corresponding to the specific protein single detection mode in the blood analyzer 10 performs detection, that is, the control module 14 is used to control the specific protein detection module 12 to perform detection.

[0090] S302: The control module 14 determines whether the detection number of the specific protein detection module 12 is an integer multiple of the preset number.

[0091] When the specific protein detection module 12 performs detection, the control module 14 can count the detection number of the specific protein detection module 12 in the specific protein single detection mode to obtain the detection number of the specific protein detection module 12. The control module 14 is configured to compare the detection number of the specific protein detection module 12 with the preset number to determine whether the detection number is an integer multiple of the preset number. If yes, go to step S303; if no, go to step S304.

[0092] S303: When the control module 14 determines that the detection number is an integer multiple of the preset number, the control module 14 uses the first cleaning mode to clean the reaction pool corresponding to the specific protein single detection mode of the blood routine detection module 13.

[0093] In the embodiment, when the control module 14 determines that the detection number of the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 is configured to use the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0094] For example, when the specific protein detection module 12 is in the CRP single detection mode, the control module 14 counts the detection number of the specific protein detection module 12 in the specific protein single detection mode. When the control module 14 determines that the detection number is an integer multiple of the preset number, the control module 14 is configured to use the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 of the blood routine detection module 13, so as to prevent the WBC reaction pool 131 and / or the RBC reaction pool 132 from being blocked, improve the detection accuracy of the blood analyzer 10, and facilitate the use of the blood analyzer 10.

[0095] In an embodiment, the preset number is 1, and when the control module 14 determines that the detection number is an integer multiple of the preset number, the control module 14 is configured to use the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132. Since any positive integer of the detection number is an integer multiple of the preset number, the control module 14 is configured to use the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 after each detection, i.e., the control module 14 uses the first cleaning mode to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 after each detection of the specific protein detection module 12.

[0096] S304: When the control module 14 judges that the detection number is not an integer multiple of the preset number, the control module 14 adopts the second cleaning mode to clean the reaction pool corresponding to the specific protein single detection mode of the blood routine detection module 13.

[0097] When the control module 14 is used to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 by adopting the second cleaning mode, the WBC reaction pool 131 and / or the RBC reaction pool 132 can be cleaned by diluent to avoid mutual contamination of multiple whole blood samples in the WBC reaction pool 131 and / or the RBC reaction pool 132.

[0098] In an embodiment, the preset number is greater than 1, and when the control module 14 judges that the detection number is not an integer multiple of the preset number, the control module 14 is used to clean the WBC reaction pool 131 and / or the RBC reaction pool 132 by adopting the second cleaning mode. For example, the preset number is 3, the control module 14 counts the detection number of the specific protein detection module 12 as 2, and then the control module 14 judges that the detection number is not an integer multiple of the preset number, and then the WBC reaction pool 131 and / or the RBC reaction pool 132 is cleaned by adopting the second cleaning mode.

[0099] Please refer to Figure 4 as shown, Figure 4 is a flowchart of a third embodiment of the detection method of the blood analyzer of the present application. The detection method of the present embodiment comprises the following steps:

[0100] S401: When the mode selection module 11 selects the specific protein single detection mode, the control module 14 controls the specific protein detection module 12 to detect.

[0101] S402: The control module 14 judges whether the detection number of the specific protein detection module 12 is an integer multiple of the preset number.

[0102] S403: When the control module 14 judges that the detection number is an integer multiple of the preset number, the control module 14 adopts the first cleaning mode to clean the reaction pool corresponding to the specific protein single detection mode of the blood routine detection module 13.

[0103] S404: When the control module 14 judges that the detection number is not an integer multiple of the preset number, the control module 14 adopts the second cleaning mode to clean the reaction pool corresponding to the specific protein single detection mode of the blood routine detection module 13.

[0104] Steps S401-S404 are the same as steps S301-S304, and will not be repeated here.

[0105] S405: When the mode selection module 11 switches the specific protein detection mode to the detection mode containing blood routine test, the control module 14 uses the first cleaning mode to clean the reaction pools of the blood routine test module 13 and the specific protein detection mode.

[0106] Step S405 is the same as step S202, and will not be described again here.

[0107] Please see Figure 5 As shown, Figure 5 yes Figure 3 A flowchart illustrating step S301 of the first embodiment. Step S301 includes the following steps:

[0108] S501: The control module 14 controls the sampling module 15 of the blood analyzer 10 to draw whole blood samples and distribute the whole blood samples to the specific protein reaction pool 121 of the specific protein detection module 12.

[0109] The control module 14 controls the sampling module 15 to move to the test tube to draw whole blood samples from the test tube; the control module 14 controls the sampling module 15 to move to the specific protein reaction pool 121 to distribute the whole blood samples into the specific protein reaction pool 121; the control module 14 controls the sampling module 15 to perform cleaning.

[0110] S502: Control module 14 adds reagents to specific protein reaction chamber 121 and performs detection to obtain detection results.

[0111] The control module 14 can control the sampling module 15 to draw reagents and inject them into the specific protein reaction pool 121; the control module 14 can also control the sampling module 15 to perform cleaning. The whole blood sample and reagents in the specific protein reaction pool 121 are mixed and reacted, and the blood analyzer 10 detects the liquid in the specific protein reaction pool 121 to obtain the test results.

[0112] S503: Control module 14 controls sampling module 15 to distribute whole blood samples to WBC reaction chamber 131 for dilution of whole blood samples.

[0113] When the whole blood sample is allocated to the specific protein reaction pool 121, the control module 14 can control the sampling module 15 to allocate the whole blood sample to the WBC reaction pool 131. The WBC reaction pool 131 is used to dilute the whole blood sample once to obtain the diluted sample of the WBC reaction pool 131.

[0114] S504: Control module 14 controls sampling module 15 to add a portion of the diluted sample from WBC reaction cell 131 into RBC reaction cell 132 of routine blood test module 13 to calculate HCT value.

[0115] After the sampling module 15 adds a portion of the diluted sample from the WBC reaction chamber 131 to the RBC reaction chamber 132, the RBC reaction chamber 132 performs a second dilution on the diluted sample. The blood analyzer 10 then detects the liquid in the RBC reaction chamber 132 to obtain the HCT value.

[0116] S505: Control module 14 corrects the detection results based on HCT values.

[0117] Among them, the control module 14 uses HCT value to correct the detection results so that the corrected detection results are more accurate.

[0118] In the several embodiments provided in this application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For instance, the division of modules or units is only a logical functional division, and there may be other division methods in actual implementation. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed.

[0119] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment, depending on actual needs.

[0120] Furthermore, the functional units in the various embodiments of this application can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software functional unit.

[0121] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural changes made based on the description and drawings of this application, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A blood analyzer, characterized in that, The system includes a mode selection module, a complete blood count (CBC) testing module, a specific protein detection module, and a control module. The mode selection module is used to select a detection mode from multiple detection modes of the blood analyzer, including a specific protein detection mode and a detection mode that includes CBC testing. The CBC testing module is used to perform CBC testing on the blood sample. The specific protein detection module is used to perform specific protein detection on the blood sample. When the mode selection module switches the specific protein detection mode to the blood routine test mode, the control module uses a first cleaning mode to clean the reaction pools corresponding to the blood routine test module and the specific protein detection mode. The reaction chambers corresponding to the blood routine test module and the specific protein separate detection mode include a WBC reaction chamber and an RBC reaction chamber. The WBC reaction chamber is used as a dilution chamber for whole blood samples. When the mode selection module switches the specific protein separate detection mode to the detection mode containing blood routine test, the control module uses a first cleaning mode to clean the WBC reaction chamber. The gemstone hole of the WBC reaction chamber is subjected to at least one burning and backflushing. The control module is used to perform the following steps: The control module controls the sampling module of the blood analyzer to draw blood samples and distribute the blood samples to the specific protein reaction pool of the specific protein detection module; The control module adds reagents to the specific protein reaction chamber and performs detection to obtain the detection results. The control module controls the sampling module to distribute the blood sample into the WBC reaction chamber to dilute the blood sample; The control module controls the sampling module to add a portion of the diluted sample from the WBC reaction chamber into the RBC reaction chamber of the routine blood test module to calculate the HCT value; The control module corrects the detection result based on the HCT value.

2. The blood analyzer according to claim 1, characterized in that, When the mode selection module switches the specific protein detection mode to the blood routine test mode, the control module uses the first cleaning mode to clean the WBC reaction chamber and / or the RBC reaction chamber.

3. The blood analyzer according to claim 2, characterized in that, When the control module cleans the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode, the sapphire holes of the WBC reaction tank and / or the sapphire holes of the RBC reaction tank are subjected to at least one burning and backflushing; and / or, the WBC reaction tank and / or the RBC reaction tank are cleaned with a cleaning solution.

4. The blood analyzer according to claim 3, characterized in that, When the mode selection module selects the specific protein detection mode, the control module controls the specific protein detection module to perform the detection. When the control module determines that the number of detections by the specific protein detection module is an integer multiple of the preset number, the control module uses the first cleaning mode to clean the WBC reaction chamber and / or the RBC reaction chamber.

5. The blood analyzer according to claim 4, characterized in that, The preset number of times is 1, and the control module cleans the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode each time the detection is completed.

6. The blood analyzer according to claim 4, characterized in that, If the preset number of times is greater than 1, and the control module determines that the number of detections is not an integer multiple of the preset number of times, the control module adopts the second cleaning mode to clean the WBC reaction tank and / or the RBC reaction tank.

7. A detection method for a blood analyzer, characterized in that, The detection method, applied to a blood analyzer as described in any one of claims 1-6, comprises: The blood analyzer is equipped with multiple detection modes, including a specific protein detection mode and a blood routine test mode. When the mode selection module switches the specific protein detection mode to the blood routine test mode, the control module uses a first cleaning mode to clean the reaction pools corresponding to the blood routine test module and the specific protein detection mode.

8. The detection method according to claim 7, characterized in that, The reaction chambers corresponding to the blood routine test module and the specific protein individual detection mode include a WBC reaction chamber and an RBC reaction chamber. The step of the control module cleaning the reaction chambers corresponding to the blood routine test module and the specific protein individual detection mode using a first cleaning mode includes: The sapphire holes of the WBC reaction cell and / or the sapphire holes of the RBC reaction cell are subjected to at least one burning and backflushing. And / or, the WBC reaction tank and / or the RBC reaction tank are cleaned with a cleaning solution.

9. The detection method according to claim 8, characterized in that, The detection method further includes: When the mode selection module selects the specific protein detection mode, the control module controls the specific protein detection module to perform the detection. The control module determines whether the number of detections by the specific protein detection module is an integer multiple of a preset number; When the control module determines that the number of detections is an integer multiple of the preset number, the control module uses a first cleaning mode to clean the WBC reaction tank and / or the RBC reaction tank.

10. The detection method according to any one of claims 7-9, characterized in that, The steps by which the control module controls the specific protein detection module to perform detection include: The control module controls the sampling module of the blood analyzer to draw blood samples and distribute the blood samples to the specific protein reaction pool of the specific protein detection module; The control module adds reagents to the specific protein reaction chamber and performs detection to obtain the detection results. The control module controls the sampling module to distribute the blood sample into the WBC reaction chamber to dilute the blood sample; The control module controls the sampling module to add a portion of the diluted sample from the WBC reaction chamber into the RBC reaction chamber of the routine blood test module to calculate the HCT value; The control module corrects the detection result based on the HCT value.

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