A blood analyzer and its detection method

Abstract

This application discloses a blood analyzer and its detection method. The blood analyzer includes a mode selection module for selecting a detection mode from multiple detection modes, including a specific protein detection mode; a complete blood count (CBC) module for performing CBC on whole blood samples; a specific protein detection module for detecting a specific protein in whole blood samples; and a control module for controlling the specific protein detection module to perform detection when the mode selection module selects the specific protein detection mode. When the control module determines that the number of detections by the specific protein detection module is an integer multiple of a preset number, the control module uses a first cleaning mode to clean the reaction cells corresponding to the CBC and specific protein detection modes. This method prevents clogging, improves the detection accuracy of the blood analyzer, and makes it convenient for users.

Description

Technical Field

[0001] This application relates to the field of blood testing technology, and in particular to a blood analyzer and its testing method. Background Technology

[0002] With the development of academic research and clinical testing, blood analyzers have high practical value in performing combined blood routine tests and tests for SAA (serum amyloid A protein) or CRP (C-reactive protein), which can greatly help patients in the detection and diagnosis of infection types.

[0003] Existing integrated blood routine and specific protein testing machines are very prone to clogging, causing inconvenience to users. Summary of the Invention

[0004] To address the aforementioned issues, this application provides a blood analyzer and its detection method, which employs a first cleaning mode to clean the reaction cells corresponding to the routine blood test module and the specific protein individual detection mode, thereby preventing clogging.

[0005] One technical solution adopted in this application is to provide a blood analyzer, comprising:

[0006] The mode selection module is used to select one detection mode from multiple detection modes of the blood analyzer, including a specific protein individual detection mode;

[0007] The complete blood count (CBC) module is used to perform CBC analysis on whole blood samples.

[0008] A specific protein detection module is used to detect specific proteins in the whole blood sample.

[0009] The control module is used to control the specific protein detection module to perform detection when the mode selection module selects the specific protein individual detection mode;

[0010] When the control module determines that the number of detections by the specific protein detection module is an integer multiple of a preset number, the control module is used to clean the reaction pools corresponding to the blood routine detection module and the specific protein individual detection mode using a first cleaning mode.

[0011] The blood routine detection module and the reaction pool corresponding to the specific protein individual detection mode include a WBC reaction pool and an RBC reaction pool. When the control module determines that the number of detections by the specific protein detection module is an integer multiple of the preset number, the control module uses a first cleaning mode to clean the WBC reaction pool and / or the RBC reaction pool.

[0012] Among them, the multiple detection modes include a detection mode containing routine blood tests. When the mode selection module switches the specific protein individual detection mode to the detection mode containing routine blood tests, the control module uses the first cleaning mode to clean the WBC reaction chamber and / or the RBC reaction chamber.

[0013] Wherein, the preset number of times is 1, and the control module is used to clean the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode when each detection is completed.

[0014] Wherein, the preset number of times is greater than 1, when the control module determines that the number of detections is not an integer multiple of the preset number of times, the control module is used to clean the WBC reaction tank and / or the RBC reaction tank using a second cleaning mode.

[0015] Specifically, when the control module cleans the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode, the sapphire holes of the WBC reaction tank and / or the sapphire holes of the RBC reaction tank are subjected to at least one burning and backflushing; and / or, the WBC reaction tank and / or the RBC reaction tank are cleaned with a hemolysing agent.

[0016] Another technical solution adopted in this application is: providing a detection method for a blood analyzer, applied to the aforementioned blood analyzer, the detection method comprising:

[0017] The blood analyzer is equipped with multiple detection modes, including a mode for detecting specific proteins individually.

[0018] When the mode selection module selects the specific protein detection mode, the control module controls the specific protein detection module to perform the detection.

[0019] The control module determines whether the number of detections by the specific protein detection module is an integer multiple of a preset number;

[0020] When the control module determines that the number of detections is an integer multiple of the preset number, the control module uses the reaction cell corresponding to the first cleaning mode and the specific protein individual detection mode for cleaning.

[0021] The blood routine test module and the reaction pool corresponding to the specific protein individual detection mode include a WBC reaction pool and an RBC reaction pool. The multiple detection modes include detection modes that include blood routine tests. The detection method further includes:

[0022] When the mode selection module switches the specific protein detection mode to the blood routine test mode, the control module uses the first cleaning mode to clean the WBC reaction chamber and / or the RBC reaction chamber.

[0023] Wherein, the preset number of times is 1, and the step of cleaning the reaction tank corresponding to the specific protein detection mode by the control module includes:

[0024] The control module cleans the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode after each detection is completed.

[0025] Wherein, the step of the control module determining whether the number of detections is an integer multiple of the preset number, where the preset number is greater than 1, includes:

[0026] When the control module determines that the number of detections is not an integer multiple of the preset number, the control module uses a second cleaning mode to clean the WBC reaction tank and / or the RBC reaction tank.

[0027] The step of the control module cleaning the reaction pools corresponding to the blood routine detection module and the specific protein individual detection mode using the first cleaning mode includes:

[0028] The sapphire holes of the WBC reaction cell and / or the sapphire holes of the RBC reaction cell are subjected to at least one burning and backflushing.

[0029] And / or, the WBC reaction tank and / or the RBC reaction tank are cleaned with a hemolysin.

[0030] The steps by which the control module controls the specific protein detection module to perform detection include:

[0031] The control module controls the sampling module of the blood analyzer to draw whole blood samples and distribute the whole blood samples to the specific protein reaction pool of the specific protein detection module;

[0032] The control module adds reagents to the specific protein reaction chamber and performs detection to obtain the detection results.

[0033] The control module controls the sampling module to distribute the whole blood sample into the WBC reaction chamber to dilute the whole blood sample;

[0034] The control module controls the sampling module to add a portion of the diluted sample from the WBC reaction chamber into the RBC reaction chamber of the routine blood test module to calculate the HCT value;

[0035] The control module corrects the detection result based on the HCT value.

[0036] The blood analyzer of this application includes a mode selection module, a routine blood count (RBC) detection module, a specific protein detection module, and a control module. The mode selection module is used to select a detection mode from a variety of detection modes of the blood analyzer. When the mode selection module selects the specific protein detection mode, the control module controls the specific protein detection module to perform the detection. When the control module determines that the number of detections by the specific protein detection module is an integer multiple of a preset number, the control module uses a first cleaning mode to clean the reaction chambers corresponding to the RBC and specific protein detection modes. When the blood analyzer is in the specific protein detection mode and the number of detections by the specific protein detection module is an integer multiple of a preset number, the first cleaning mode is used to clean the reaction chambers corresponding to the RBC and specific protein detection modes. This can clear blockages in the reaction chambers corresponding to the RBC and specific protein detection modes, prevent clogging, improve the detection accuracy of the blood analyzer, and make it convenient for users. Attached Figure Description

[0037] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0038] Figure 1 This is a schematic diagram of the structure of the first embodiment of the blood analyzer of this application;

[0039] Figure 2 This is a flowchart illustrating the first embodiment of the detection method of the blood analyzer of this application;

[0040] Figure 3 This is a flowchart illustrating the second embodiment of the detection method of the blood analyzer of this application;

[0041] Figure 4 yes Figure 2 A flowchart illustrating step S202 in the first embodiment. Detailed Implementation

[0042] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. It is understood that the specific embodiments described herein are only for explaining this application and not for limiting it. Furthermore, it should be noted that, for ease of description, only the parts related to this application are shown in the accompanying drawings, not all structures. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0043] The terms "first," "second," etc., used in this application are used to distinguish different objects, not to describe a specific order. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products, or apparatuses.

[0044] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0045] Please see Figure 1 As shown, Figure 1 This is a schematic diagram of the structure of the first embodiment of the blood analyzer of this application. The blood analyzer 10 of this application includes a mode selection module 11, a specific protein detection module 12, a routine blood test module 13, and a control module 14.

[0046] The specific protein detection module 12 is used to perform specific protein detection on whole blood samples, and the complete blood count (CBC) detection module 13 is used to perform CBC detection on whole blood samples. The control module 14 can be connected to the mode selection module 11, the specific protein detection module 12, and the CBC detection module 13, respectively. In other embodiments, the specific protein detection module 12 can detect other blood samples, such as serum samples.

[0047] The complete blood count (CBC) includes WBC (White Blood Cell) testing, HGB (Hemoglobin) testing, RBC (Red Blood Cell) testing, DIFF (Differential White Blood Cell Count) testing, or RET (Reticulocyte Count) testing. Specific proteins include one of the following: SAA, CRP, TRF (transferrin), Hs-CRP (high-sensitivity C-reactive protein), PCT (procalcitonin), and D-dimer.

[0048] In one embodiment, the blood analyzer 10 may include at least two specific protein detection modules 12, such as an SAA detection module and a CRP detection module, that is, the blood analyzer 10 is an integrated machine for combined blood routine, SAA and CRP testing.

[0049] The mode selection module 11 is used to select one detection mode from multiple detection modes of the blood analyzer 10. Optionally, the mode selection module 11 is also used to preset multiple detection modes of the blood analyzer 10.

[0050] Specifically, the blood analyzer 10 offers multiple detection modes, including a specific protein individual detection mode. This mode outputs only specific protein parameters and HCT (Hematocrit, hematocrit value) test results (i.e., HCT value). Specific protein individual detection modes can be SAA individual detection mode, CRP individual detection mode, SAA+CRP individual detection mode, TRF individual detection mode, Hs-CRP individual detection mode, PCT individual detection mode, or D-Dimer individual detection mode, etc. For example, the blood analyzer 10 offers multiple detection modes including SAA individual detection mode, CRP individual detection mode, or SAA+CRP individual detection mode.

[0051] When the mode selection module 11 selects a specific protein detection mode, the specific protein detection module 12 in the blood analyzer 10 corresponding to the specific protein detection mode performs the detection; that is, the control module 14 is used to control the specific protein detection module 12 to perform the detection. For example, if the mode selection module 11 selects the SAA single detection mode, the control module 14 is used to control the specific protein detection module 12 (such as the SAA detection module) corresponding to the SAA single detection mode to perform the detection on the whole blood sample; or, if the mode selection module 11 selects the CRP single detection mode, the control module 14 is used to control the specific protein detection module 12 (such as the CRP detection module) corresponding to the CRP single detection mode to perform the detection on the whole blood sample; or, if the mode selection module 11 selects the SAA+CRP single detection mode, the control module 14 is used to control the specific protein detection module 13 (such as the SAA detection module and the CRP detection module) corresponding to the SAA+CRP single detection mode to perform the detection on the whole blood sample.

[0052] When the specific protein detection module 12 performs detection, the control module 14 can count the number of times the specific protein detection module 12 performs detection in the specific protein standalone detection mode to obtain the detection count of the specific protein detection module 12. The control module 14 is used to compare the detection count of the specific protein detection module 12 with a preset number to determine whether the detection count is an integer multiple of the preset number; when the control module 14 determines that the detection count of the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 is used to clean the reaction pool corresponding to the blood routine detection module 13 and the specific protein standalone detection mode using the first cleaning mode. The integer multiple is a positive integer greater than 0, such as an integer multiple of 1, 2, 3, 4, 5 or 6, etc.

[0053] The blood routine test module 13 and the reaction pool corresponding to the specific protein separate detection mode include WBC reaction pool 131 and RBC reaction pool 132. When the control module 14 determines that the number of detections of the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 uses the first cleaning mode to clean WBC reaction pool 131 and / or RBC reaction pool 132.

[0054] In one embodiment, the control module 14 uses a first cleaning mode to clean the WBC reaction cell 131 to remove blockages, prevent blockages in the WBC reaction cell 131, and improve the detection accuracy of the blood analyzer.

[0055] For example, when the control module 14 determines that the number of tests performed by the specific protein detection module 12 is an integer multiple of a preset number, the control module 14 uses the first cleaning mode to clean the WBC reaction chamber 131 to remove blockages. Specifically, the blood analyzer 10 uses the WBC reaction chamber 131 as a dilution chamber for whole blood samples in the CRP standalone detection mode, which makes the WBC reaction chamber 131 prone to blockages. Therefore, when the control module 14 determines that the number of tests performed by the specific protein detection module 12 is an integer multiple of a preset number, the control module 14 needs to use the first cleaning mode to clean the WBC reaction chamber 131 to remove blockages.

[0056] In one embodiment, the control module 14 uses a first cleaning mode to clean the RBC reaction chamber 132 to remove blockages, thereby ensuring the accuracy of the HCT value and improving the detection accuracy of the blood analyzer.

[0057] In one embodiment, the control module 14 uses a first cleaning mode to clean the WBC reaction chamber 131 and the RBC reaction chamber 132 to remove blockages in the WBC reaction chamber 131 and the RBC reaction chamber 132, prevent blockages in the WBC reaction chamber 131, ensure the accuracy of the HCT value, improve the detection accuracy of the blood analyzer, and make it convenient for users to use.

[0058] In this embodiment, when the control module 14 determines that the number of detections by the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 adopts the first cleaning mode to clean the reaction pools corresponding to the blood routine detection module 13 and the specific protein individual detection mode. This can clear blockages in the reaction pools corresponding to the blood routine detection module and the specific protein individual detection mode, prevent clogging, improve the detection accuracy of the blood analyzer, and make it convenient for users to use.

[0059] In this application, the blood analyzer 10 has multiple detection modes, all of which are measurement parameter modes. For example, if the mode selection module 11 selects the specific protein detection mode as the CRP detection mode, then the specific protein detection module 12 will perform CRP detection on the whole blood sample.

[0060] Optionally, the blood analyzer 10 of this application can be configured with a sample introduction mode. The sample introduction mode refers to the method by which the blood analyzer 10 draws whole blood samples from test tubes. The sample introduction modes include automatic sample introduction mode and open sample introduction mode. In automatic sample introduction mode, the sampler of the blood analyzer 10 pushes the test tube to draw the whole blood sample from the test tube into the blood analyzer 10. For example, if the user places a test tube rack on the blood analyzer 10, the blood analyzer 10 can continuously test whole blood samples from multiple test tubes on the test tube rack. In open sample introduction mode, the user places the test tube under the sampling needle of the blood analyzer 10, and the blood analyzer 10 draws and tests the whole blood sample from the test tube.

[0061] like Figure 1 As shown, the blood analyzer 10 also includes a sampling module 15 connected to the control module 14. The sampling module 15 is used to collect whole blood samples and distribute them to the specific protein detection module 12. The following describes in detail the detection steps of the specific protein detection module 12 on the whole blood sample when the specific protein detection mode is selected by the mode selection module 11:

[0062] The control module 14 controls the sampling module 15 of the blood analyzer 10 to draw whole blood samples and distribute them to the specific protein reaction chamber 121 of the specific protein detection module 12. Specifically, the control module 14 controls the sampling module 15 to move to a test tube to draw whole blood samples; the control module 14 controls the sampling module 15 to move to the specific protein reaction chamber 121 to distribute whole blood samples to the specific protein reaction chamber 121; and the control module 14 controls the sampling module 15 to perform cleaning.

[0063] The control module 14 adds reagents to the specific protein reaction chamber 121 and performs detection to obtain the detection results, which include specific protein parameters. Specifically, the control module 14 can control the sampling module 15 to draw reagents and inject them into the specific protein reaction chamber 121; the control module 14 also controls the sampling module 15 to perform cleaning. The whole blood sample and reagents in the specific protein reaction chamber 121 are mixed and reacted, and the blood analyzer 10 detects the liquid within the specific protein reaction chamber 121 to obtain the detection results.

[0064] Control module 14 controls sampling module 15 to dispense whole blood samples into WBC reaction chamber 131 for dilution. Specifically, control module 14 can simultaneously dispense whole blood samples into specific protein reaction chamber 121 and control sampling module 15 to dispense whole blood samples into WBC reaction chamber 131. WBC reaction chamber 131 is used for a single dilution of the whole blood sample, resulting in a diluted sample in WBC reaction chamber 131.

[0065] Control module 14 controls sampling module 15 to add a partially diluted sample from WBC reaction chamber 131 to RBC reaction chamber 132 of blood routine testing module 13 to calculate HCT value. After sampling module 15 adds the partially diluted sample from WBC reaction chamber 131 to RBC reaction chamber 132, RBC reaction chamber 132 performs a secondary dilution of the diluted sample, and blood analyzer 10 analyzes the liquid in RBC reaction chamber 132 to obtain HCT value.

[0066] The control module 14 corrects the detection results based on the HCT value, wherein the control module 14 uses the HCT value to correct the detection results so that the corrected detection results are more accurate.

[0067] When the control module 14 determines that the number of tests is an integer multiple of the preset number, the blood analyzer 10 of this application uses a first cleaning mode to clean the WBC reaction cell 131 and / or RBC reaction cell 132 of the blood routine test module 13. This can clear blockages in the WBC reaction cell 131 and / or RBC reaction cell 132, prevent blockages in the WBC reaction cell 131 and / or RBC reaction cell 132, ensure the accuracy of the HCT value, ensure that the blood analyzer 10 can work normally, and improve the detection accuracy of the blood analyzer 10.

[0068] In one embodiment, when the control module 14 cleans the WBC reaction tank 131 and / or the RBC reaction tank 132 using the first cleaning mode, the sapphire holes of the WBC reaction tank 131 and / or the sapphire holes of the RBC reaction tank 132 are subjected to at least one burning and backflushing, for example, the sapphire holes of the WBC reaction tank 131 and / or the sapphire holes of the RBC reaction tank 132 are subjected to multiple burning and backflushing to remove blockages from the sapphire holes of the WBC reaction tank 131 and / or the sapphire holes of the RBC reaction tank 132.

[0069] In one embodiment, when the control module 14 cleans the WBC reaction cell 131 and / or the RBC reaction cell 132 using the first cleaning mode, the WBC reaction cell 131 and / or the RBC reaction cell 132 are cleaned with a hemolysin, for example, by using reagent R1 to clean the WBC reaction cell 131 and / or the RBC reaction cell 132 to remove blockages from the gemstone holes of the WBC reaction cell 131 and / or the RBC reaction cell 132.

[0070] In other embodiments, the WBC reaction chamber 131 and / or the RBC reaction chamber 132 may be cleaned with a hemolytic agent, and the sapphire holes of the WBC reaction chamber 131 and / or the sapphire holes of the RBC reaction chamber 132 may be subjected to at least one burning and backflushing to de-clog the WBC reaction chamber 131 and / or the RBC reaction chamber 132, thereby improving the de-clogging effect of the WBC reaction chamber 131 and / or the RBC reaction chamber 132.

[0071] In one embodiment, the blood analyzer 10 includes multiple detection modes, including a specific protein detection mode and a blood routine test mode. The blood routine test mode indicates that the output result includes a measurement mode of the total number of white blood cells, red blood cells, platelets, or hemoglobin. For example, the blood routine test mode is CBC (complete blood count) + Diff + CRP detection mode, CBC + Diff + SAA detection mode, CBC + Diff + SAA + CRP detection mode, CBC + SAA detection mode, CBC + CRP detection mode, or CBC + CRP + SAA detection mode, etc.

[0072] When the mode selection module 11 switches from a specific protein detection mode to a blood routine test mode, the control module 14 uses a first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132. For example, when the mode selection module 11 switches from a CRP detection mode to a blood routine test mode, the control module 14 uses the first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 to remove any blockages.

[0073] In one embodiment, the preset number of detections is 1. When the control module 14 determines that the number of detections is an integer multiple of the preset number, the control module 14 is used to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 using a first cleaning mode. Since any positive integer number of detections is an integer multiple of the preset number, the control module 14 is used to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 using the first cleaning mode after each detection is completed. That is, when the specific protein detection module 12 completes each detection, the control module 14 uses the first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132.

[0074] In one embodiment, the preset number of detections is greater than 1. When the control module 14 determines that the number of detections is not an integer multiple of the preset number, the control module 14 uses a second cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132. For example, if the preset number of detections is 3, and the control module 14 counts that the number of detections by the specific protein detection module 12 is 2, then the control module 14 determines that the number of detections is not an integer multiple of the preset number, and uses the second cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132.

[0075] When the control module 14 is used to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 in the second cleaning mode, the WBC reaction chamber 131 and / or the RBC reaction chamber 132 can be cleaned with diluent to avoid cross-contamination of multiple whole blood samples in the WBC reaction chamber 131 and / or the RBC reaction chamber 132.

[0076] In this embodiment, when the blood analyzer 10 is in the specific protein detection mode, and the number of detections by the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 is used to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 using the first cleaning mode. This can remove blockages from the WBC reaction chamber 131 and / or the RBC reaction chamber 132, thereby preventing blockages and improving the detection accuracy of the blood analyzer 10.

[0077] Please see Figure 2 As shown, Figure 2 This is a flowchart illustrating the first embodiment of the detection method for the blood analyzer of this application. The detection method of this embodiment is applied to the aforementioned blood analyzer 10, and the detection method includes the following steps:

[0078] S201: The blood analyzer 10 has multiple detection modes, including a mode for detecting specific proteins individually.

[0079] Among them, the blood analyzer 10 has multiple detection modes, including a specific protein detection mode. The specific protein detection mode means that only specific protein parameters and HCT test results are output. The specific protein detection mode can be SAA detection mode, CRP detection mode, SAA+CRP detection mode, TRF detection mode, Hs-CRP detection mode, PCT detection mode or D-Dimer detection mode, etc.

[0080] S202: When the mode selection module 11 selects a specific protein detection mode, the control module 14 controls the specific protein detection module 12 to perform detection.

[0081] When the mode selection module 11 selects a specific protein detection mode, the specific protein detection module 12 in the blood analyzer 10 corresponding to the specific protein detection mode performs the detection; that is, the control module 14 is used to control the specific protein detection module 12 to perform the detection. For example, if the mode selection module 11 selects the CRP detection mode, the control module 14 is used to control the specific protein detection module 12 (such as the CRP detection module) corresponding to the CRP detection mode to perform the detection on the whole blood sample.

[0082] S203: The control module 14 determines whether the number of detections by the specific protein detection module 12 is an integer multiple of the preset number.

[0083] When the specific protein detection module 12 performs detection, the control module 14 can count the number of times the specific protein detection module 12 performs detection in the specific protein standalone detection mode to obtain the detection count of the specific protein detection module 12. The control module 14 is used to compare the detection count of the specific protein detection module 12 with a preset number to determine whether the detection count is an integer multiple of the preset number. If yes, proceed to step S204; if no, proceed to step S205.

[0084] S204: When the control module 14 determines that the number of tests is an integer multiple of the preset number, the control module 14 uses the first cleaning mode to clean the reaction pools corresponding to the blood routine test module 13 and the specific protein individual test mode.

[0085] The blood routine test module 13 and the reaction pool corresponding to the specific protein separate detection mode include WBC reaction pool 131 and RBC reaction pool 132. When the control module 14 determines that the number of detections of the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 uses the first cleaning mode to clean WBC reaction pool 131 and / or RBC reaction pool 132.

[0086] In one embodiment, the control module 14 uses a first cleaning mode to clean the WBC reaction cell 131 to remove blockages, prevent blockages in the WBC reaction cell 131, and improve the detection accuracy of the blood analyzer.

[0087] In one embodiment, the control module 14 uses a first cleaning mode to clean the RBC reaction chamber 132 to remove blockages, thereby ensuring the accuracy of the HCT value and improving the detection accuracy of the blood analyzer.

[0088] In one embodiment, the control module 14 uses a first cleaning mode to clean the WBC reaction chamber 131 and the RBC reaction chamber 132 to remove blockages in the WBC reaction chamber 131 and the RBC reaction chamber 132, prevent blockages in the WBC reaction chamber 131, ensure the accuracy of the HCT value, improve the detection accuracy of the blood analyzer, and make it convenient for users to use.

[0089] In this embodiment, when the control module 14 determines that the number of detections by the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 adopts the first cleaning mode to clean the reaction pools corresponding to the blood routine detection module 13 and the specific protein individual detection mode. This can clear blockages in the reaction pools corresponding to the blood routine detection module and the specific protein individual detection mode, prevent clogging, improve the detection accuracy of the blood analyzer, and make it convenient for users to use.

[0090] S205: When the control module 14 determines that the number of tests is not an integer multiple of the preset number, the control module 14 adopts the second cleaning mode to clean the reaction pools corresponding to the blood routine test module 13 and the specific protein individual test mode.

[0091] When the control module 14 is used to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 in the second cleaning mode, the WBC reaction chamber 131 and / or the RBC reaction chamber 132 can be cleaned with diluent to avoid cross-contamination of multiple whole blood samples in the WBC reaction chamber 131 and / or the RBC reaction chamber 132.

[0092] In this embodiment, when the blood analyzer 10 is in the specific protein detection mode, and the number of detections by the specific protein detection module 12 is an integer multiple of the preset number, the control module 14 is used to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 using the first cleaning mode. This can remove blockages from the WBC reaction chamber 131 and / or the RBC reaction chamber 132, thereby preventing blockages and improving the detection accuracy of the blood analyzer 10.

[0093] In step S204, the preset number of detections is 1. When the control module 14 determines that the number of detections is an integer multiple of the preset number, the control module 14 uses a first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132. Since any positive integer number of detections is an integer multiple of the preset number, the control module 14 uses the first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 after each detection is completed. That is, when the specific protein detection module 12 completes each detection, the control module 14 uses the first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132.

[0094] In step S205, if the preset number of detections is greater than 1, and the control module 14 determines that the number of detections is not an integer multiple of the preset number, the control module 14 uses a second cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132. For example, if the preset number of detections is 3, and the control module 14 counts 2 detections by the specific protein detection module 12, then the control module 14 determines that the number of detections is not an integer multiple of the preset number, and uses the second cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132.

[0095] Please see Figure 3 As shown, Figure 3 This is a flowchart illustrating a second embodiment of the detection method for the blood analyzer of this application. The detection method of this embodiment includes the following steps:

[0096] S301: The blood analyzer 10 has multiple detection modes, including a mode for detecting specific proteins individually.

[0097] S302: When the mode selection module 11 selects a specific protein detection mode, the control module 14 controls the specific protein detection module 12 to perform detection.

[0098] S303: Control module 14 determines whether the number of detections by the specific protein detection module 12 is an integer multiple of the preset number.

[0099] S304: When the control module 14 determines that the number of tests is an integer multiple of the preset number, the control module 14 uses the first cleaning mode to clean the reaction pools corresponding to the blood routine test module 13 and the specific protein individual test mode.

[0100] S305: When the control module 14 determines that the number of tests is not an integer multiple of the preset number, the control module 14 adopts the second cleaning mode to clean the reaction pools corresponding to the blood routine test module 13 and the specific protein individual test mode.

[0101] Steps S301-S305 are the same as steps S201-S205, and will not be repeated here.

[0102] S306: When the mode selection module 11 switches the specific protein detection mode to the detection mode containing blood routine test, the control module 14 uses the first cleaning mode to clean the reaction pools of the blood routine test module 13 and the specific protein detection mode.

[0103] When the mode selection module 11 switches from a specific protein detection mode to a blood routine test mode, the control module 14 uses a first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132. For example, when the mode selection module 11 switches from a CRP detection mode to a blood routine test mode, the control module 14 uses the first cleaning mode to clean the WBC reaction chamber 131 and / or the RBC reaction chamber 132 to remove any blockages.

[0104] Please see Figure 4 As shown, Figure 4 yes Figure 2 A flowchart illustrating the first embodiment of step S202. Step S202 includes the following steps:

[0105] S401: The control module 14 controls the sampling module 15 of the blood analyzer 10 to draw whole blood samples and distribute the whole blood samples to the specific protein reaction pool 121 of the specific protein detection module 12.

[0106] The control module 14 controls the sampling module 15 to move to the test tube to draw whole blood samples from the test tube; the control module 14 controls the sampling module 15 to move to the specific protein reaction pool 121 to distribute the whole blood samples into the specific protein reaction pool 121; the control module 14 controls the sampling module 15 to perform cleaning.

[0107] S402: Control module 14 adds reagents to specific protein reaction chamber 121 and performs detection to obtain detection results.

[0108] The control module 14 can control the sampling module 15 to draw reagents and inject them into the specific protein reaction pool 121; the control module 14 can also control the sampling module 15 to perform cleaning. The whole blood sample and reagents in the specific protein reaction pool 121 are mixed and reacted, and the blood analyzer 10 detects the liquid in the specific protein reaction pool 121 to obtain the test results.

[0109] S403: Control module 14 controls sampling module 15 to distribute whole blood samples to WBC reaction cell 131 for dilution of whole blood samples.

[0110] When the whole blood sample is allocated to the specific protein reaction pool 121, the control module 14 can control the sampling module 15 to allocate the whole blood sample to the WBC reaction pool 131. The WBC reaction pool 131 is used to dilute the whole blood sample once to obtain the diluted sample of the WBC reaction pool 131.

[0111] S404: Control module 14 controls sampling module 15 to add a portion of the diluted sample from WBC reaction cell 131 into RBC reaction cell 132 of routine blood test module 13 to calculate HCT value.

[0112] After the sampling module 15 adds the diluted sample from the WBC reaction chamber 131 to the RBC reaction chamber 132, the RBC reaction chamber 132 performs a second dilution on the diluted sample. The blood analyzer 10 then detects the liquid in the RBC reaction chamber 132 to obtain the HCT value.

[0113] S405: Control module 14 corrects the detection results based on HCT values.

[0114] Among them, the control module 14 uses HCT value to correct the detection results so that the corrected detection results are more accurate.

[0115] In the several embodiments provided in this application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are merely illustrative, and the division of modules or units is only a logical functional division. In actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed.

[0116] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment, depending on actual needs.

[0117] Furthermore, the functional units in the various embodiments of this application can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software functional unit.

[0118] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural changes made based on the description and drawings of this application, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A blood analyzer, characterized in that, include: The mode selection module is used to select one detection mode from multiple detection modes of the blood analyzer, including a specific protein individual detection mode; The complete blood count (CBC) module is used to perform CBC analysis on whole blood samples. A specific protein detection module is used to detect specific proteins in the whole blood sample. The control module is used to control the specific protein detection module to perform detection when the mode selection module selects the specific protein individual detection mode; When the control module determines that the number of detections by the specific protein detection module is an integer multiple of a preset number, the control module is used to clean the reaction pool in the blood routine detection module corresponding to the specific protein individual detection mode using a first cleaning mode. The blood routine testing module includes a WBC reaction chamber and an RBC reaction chamber in the reaction chamber corresponding to the specific protein individual detection mode. When the mode selection module selects the specific protein individual detection mode, the WBC reaction chamber serves as the dilution chamber for the whole blood sample. When the control module determines that the number of tests performed by the specific protein detection module is an integer multiple of the preset number, the control module uses a first cleaning mode to clean the WBC reaction chamber.

2. The blood analyzer according to claim 1, characterized in that, When the control module determines that the number of detections by the specific protein detection module is an integer multiple of the preset number, the control module uses the first cleaning mode to clean the RBC reaction chamber.

3. The blood analyzer according to claim 2, characterized in that, The multiple detection modes include a detection mode containing routine blood tests. When the mode selection module switches the specific protein detection mode to the detection mode containing routine blood tests, the control module uses the first cleaning mode to clean the WBC reaction chamber and / or the RBC reaction chamber.

4. The blood analyzer according to claim 2, characterized in that, The preset number of times is 1, and the control module is used to clean the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode each time the detection is completed.

5. The blood analyzer according to claim 2, characterized in that, If the preset number of times is greater than 1, when the control module determines that the number of detections is not an integer multiple of the preset number of times, the control module is used to clean the WBC reaction tank and / or the RBC reaction tank using a second cleaning mode.

6. The blood analyzer according to any one of claims 1-5, characterized in that, When the control module cleans the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode, the sapphire holes of the WBC reaction tank and / or the sapphire holes of the RBC reaction tank are subjected to at least one burning and backflushing; and / or, the WBC reaction tank and / or the RBC reaction tank are cleaned with a hemolysing agent.

7. A detection method for a blood analyzer, characterized in that, Applied to a blood analyzer as described in any one of claims 1-6, the reaction chamber in the routine blood test module corresponding to the specific protein individual detection mode includes a WBC reaction chamber and an RBC reaction chamber, and the detection method includes: The blood analyzer is equipped with multiple detection modes, including a mode for detecting specific proteins individually. When the mode selection module selects the specific protein detection mode, the control module controls the specific protein detection module to perform the detection. The control module determines whether the number of detections by the specific protein detection module is an integer multiple of a preset number; When the control module determines that the number of tests is an integer multiple of the preset number, the control module uses a first cleaning mode to clean the reaction tank in the blood routine test module corresponding to the specific protein individual detection mode; Specifically, when the mode selection module selects the specific protein detection mode, the WBC reaction chamber serves as the dilution chamber for the whole blood sample; when the control module determines that the number of detections by the specific protein detection module is an integer multiple of the preset number, the control module uses the first cleaning mode to clean the WBC reaction chamber.

8. The detection method according to claim 7, characterized in that, The multiple detection modes include those involving routine blood tests, and the detection method further includes: When the mode selection module switches the specific protein detection mode to the blood routine test mode, the control module uses the first cleaning mode to clean the WBC reaction chamber and / or the RBC reaction chamber.

9. The detection method according to claim 7, characterized in that, The preset number of times is 1, and the step of cleaning the reaction tank corresponding to the specific protein detection mode by the control module includes: The control module cleans the WBC reaction tank and / or the RBC reaction tank using the first cleaning mode after each detection is completed.

10. The detection method according to claim 7, characterized in that, The step of the control module determining whether the number of detections is an integer multiple of the preset number, where the preset number is greater than 1, includes: When the control module determines that the number of detections is not an integer multiple of the preset number, the control module uses a second cleaning mode to clean the WBC reaction tank and / or the RBC reaction tank.

11. The detection method according to any one of claims 8-10, characterized in that, The steps of the control module cleaning the reaction tanks corresponding to the routine blood test module and the specific protein individual detection mode using the first cleaning mode include: The sapphire holes of the WBC reaction cell and / or the sapphire holes of the RBC reaction cell are subjected to at least one burning and backflushing. And / or, the WBC reaction tank and / or the RBC reaction tank are cleaned with a hemolysin.

12. The detection method according to any one of claims 8-10, characterized in that, The steps by which the control module controls the specific protein detection module to perform detection include: The control module controls the sampling module of the blood analyzer to draw whole blood samples and distribute the whole blood samples to the specific protein reaction pool of the specific protein detection module; The control module adds reagents to the specific protein reaction chamber and performs detection to obtain the detection results. The control module controls the sampling module to distribute the whole blood sample into the WBC reaction chamber to dilute the whole blood sample; The control module controls the sampling module to add a portion of the diluted sample from the WBC reaction chamber into the RBC reaction chamber of the routine blood test module to calculate the HCT value; The control module corrects the detection result based on the HCT value.

Images