Simulated organ internal radiopharmaceutical metabolism radiation dose measuring device and measuring method

Abstract

The application relates to a simulator organ radioactive medicine metabolism radiation dose measuring device and a measuring method. The measuring device comprises a main body container, a lesion simulation shell is arranged in the main body container, a plurality of radiation dosimeters are distributed on the lesion simulation shell, a balloon is arranged in the lesion simulation shell, a dosimeter channel is arranged on the lesion simulation shell, one end of the dosimeter channel extends to the center position of the lesion simulation shell, the other end of the dosimeter channel extends to the outside of the main body container, a medicine inlet pipe and a medicine outlet pipe are communicated with the balloon, a water inlet pipe and a water outlet pipe are arranged on the lesion simulation shell. The application can directly measure the radiation dose of the radioactive source, the result is objective and true, the total activity or total amount of the radioactive nuclide given to the patient does not need to be known in advance, the problem of nuclide loss in the medicine giving process is solved, the different metabolism speeds of the nuclide in the organ where the lesion is located can be simulated, the dose measurement is more in line with the actual situation and more accurate.

Description

Technical Field

[0001] This invention relates to a radiopharmaceutical metabolism measurement technique, specifically a device and method for simulating the radiation dose measurement of radiopharmaceutical metabolism within organs. Background Technology

[0002] Radioactive isotopes are widely used to treat various diseases, such as iodine-131 radionuclide therapy for hyperthyroidism and yttrium-90 radionuclide embolization therapy for liver cancer. The mechanism of these treatments involves oral or intravenous administration, allowing the radionuclide to accumulate in the lesion area. The radiation released by the radionuclide kills the cells in the lesion, achieving a therapeutic effect. Theoretically, the local radiation dose is directly related to the therapeutic effect and complications. Currently, methods of treating diseases with liquid radionuclides cannot accurately evaluate the radiation dose around the lesion. The radiation dose at the lesion is obtained solely through calculation. This calculation method has the following drawbacks: 1. The total activity of the radionuclide administered orally or by injection to the patient must be accurately known; 2. The metabolic rate of the radionuclide in the organ where the lesion is located must be known; 3. It is impossible for all the radionuclide to reach the target lesion; some loss is inevitable, and the amount of loss cannot be accurately accounted for in the calculation; 4. It cannot accurately reflect the two-dimensional and three-dimensional dose distribution of the target lesion; 5. It cannot evaluate the dose to organs at risk; 6. It cannot accurately predict the therapeutic effect and complications. Therefore, inaccurate dosage often leads to recurrence of the disease or the occurrence of complications. Summary of the Invention

[0003] The purpose of this invention is to provide a device and method for measuring radiation dose in simulated organ radiopharmaceutical metabolism, in order to solve the problem that the radiation dose of lesions is currently calculated but cannot be accurately obtained.

[0004] The present invention is implemented as follows: a radiation dose measurement device simulating intra-organ radiopharmaceutical metabolism includes a main container, a lesion simulation shell disposed within the main container, a plurality of radiation dosimeters distributed on the lesion simulation shell, a balloon disposed within the lesion simulation shell, a dosimeter channel disposed on the lesion simulation shell, one end of the dosimeter channel extending to the center of the lesion simulation shell, and the other end extending outside the main container, a drug inlet tube and a drug outlet tube connected to the balloon, and a water inlet tube and a water outlet tube disposed on the lesion simulation shell.

[0005] A pure water comparison ball is placed inside the main container, and the pure water comparison ball is filled with pure water.

[0006] Adjustment switches are installed on the inlet pipe, outlet pipe, water inlet pipe, and water outlet pipe.

[0007] The main container is cylindrical, and is filled with tissue-equivalent material.

[0008] The lesion simulation shell is formed by the joining of two hemispherical shell structures and is made of a rigid tissue equivalent material.

[0009] The radiation dosimeters are evenly distributed around the center of the lesion simulation shell.

[0010] The present invention also discloses a method for measuring radiation dose in simulated organ radiopharmaceutical metabolism, comprising the following steps.

[0011] a. Prepare a device for measuring radiation dose of radiopharmaceutical metabolism in simulated organs. The device includes a main container, a lesion simulation shell, and a balloon. During use, the balloon is located inside the lesion simulation shell, which is located inside the main container. Several radiation dosimeters are distributed on the lesion simulation shell. A dosimeter channel is provided on the lesion simulation shell, with one end extending to the center of the lesion simulation shell and the other end passing through the side wall of the main container and extending outside the main container. A drug inlet tube and a drug outlet tube are connected to the balloon. A water inlet tube and a water outlet tube are provided on the lesion simulation shell.

[0012] b. After annealing, fix the radiation dosimeter to the inner wall of the lesion simulation shell, and then place the lesion simulation shell in the center of the main container.

[0013] c. Inject a mixture of radioactive solution and fluid with the same density as the tumor into the balloon through the inlet tube. After filling, close the inlet tube and connect an infusion set containing saline to the end of the inlet tube.

[0014] d. Place the radiation dosimeter along the dosimeter channel into the center of the balloon.

[0015] e. Perform a CT scan on the entire device to determine the density and relative positional relationship of each part. If it does not meet the requirements, make fine adjustments.

[0016] f. Begin measurement. Adjust the infusion rate on the infusion tubing according to the metabolic rate of the radioactive solution for different patients or different tumors. At the same time, open the regulating switch on the outflow tubing to ensure pressure balance inside the balloon.

[0017] After measuring for a period of time, the radiation dosimeter is removed, and the radiation dose at the corresponding location of the balloon is obtained and recorded.

[0018] Select a lesion simulation shell of appropriate size based on the size of the tumor to be simulated.

[0019] By injecting a liquid with the same density as the tumor into the lesion-simulating shell through the inlet pipe, the size of the balloon can be finely adjusted.

[0020] Simultaneously, this invention can be used in conjunction with the applicant's prior application CN202110214053.3, which is a device and method for in vitro dose measurement of implanted radioactive particles. After the aforementioned measurements, this invention uses a simulated organ-based radiopharmaceutical metabolism radiation dose measurement device as the test object, fixed in the center of the fixing ring of the in vitro dose measurement device for implanted radioactive particles. The device is then used to measure the three-dimensional dose distribution of the simulated lesion.

[0021] This invention provides a radiation dose measurement device for simulating intra-organ radiopharmaceutical metabolism. It simulates the metabolism of radiopharmaceuticals within an organ in vitro and obtains accurate radiation doses through measurement. The invention uses a lesion simulation shell to simulate a lesion and a balloon to simulate a tumor. Different lesion simulation shell sizes can be selected based on the lesion size. This invention supports the combined application of multiple dosimeters to measure doses at multiple specific points. In addition to radiation dosimeters distributed on the lesion simulation shell, a dosimeter channel is also used to position the dosimeters at the center of the balloon. The balloon of this invention simulates drug concentration and metabolism in the tumor area by adjusting the flow rates of the inlet and outlet tubes. A pure water contrast sphere is used as a basis to compare the density differences of various parts on CT images, further ensuring the accuracy of dose detection.

[0022] The advantages of using this invention are as follows: 1. It eliminates the need to predict the total activity or amount of radionuclide administered to the patient. 2. It can simulate the different metabolic rates of radionuclides in the organs where the lesion is located, making dose measurement more realistic and accurate. 3. It solves the problem of radionuclide loss during drug administration; dose detection is based on the actual radionuclide reaching the lesion. 4. The software of the radiation detection equipment can accurately represent the two-dimensional and three-dimensional dose distribution of the target lesion. 5. It can accurately assess the dose distribution of organs at risk around the target area. 6. By changing dose calculation to dose detection, the dose of radiation emitted by the radiation source can be directly measured using a dose detection device, resulting in objective and accurate results. Attached Figure Description

[0023] Figure 1 This is a top view of the present invention.

[0024] Figure 2 This is a longitudinal sectional view of the present invention.

[0025] In the diagram: 1. Main container; 2. Lesion simulation shell; 3. Radiation dosimeter; 4. Balloon; 5. Dosimeter channel; 6. Drug inlet tube; 7. Drug outlet tube; 8. Water inlet tube; 9. Water outlet tube; 10. Pure water comparison ball. Detailed Implementation

[0026] like Figure 1 , Figure 2As shown, the simulated organ radiopharmaceutical metabolism radiation dose measurement device of the present invention includes a main container 1, a lesion simulation shell 2 disposed inside the main container 1, a plurality of radiation dosimeters 3 distributed on the lesion simulation shell 2, a balloon 4 disposed inside the lesion simulation shell 2, a dosimeter channel 5 disposed on the lesion simulation shell 2, one end of the dosimeter channel 5 extending to the center of the lesion simulation shell 2, and the other end extending outside the main container 1, a drug inlet tube 6 and a drug outlet tube 7 connected to the balloon 4, and a water inlet tube 8 and a water outlet tube 9 disposed on the lesion simulation shell 2.

[0027] The main container 1 is cylindrical, and tissue equivalent material is filled inside the main container 1. The lesion simulation shell 2 is fixed inside the main container 1 by the tissue equivalent material.

[0028] The lesion simulation shell 2 is formed by the joining of two hemispherical shell structures. The two hemispheres can be directly connected by threads or snap-fit, forming a seal between them after joining. The lesion simulation shell 2 is available in multiple sizes, with a diameter ranging from 2 to 10 cm, allowing for selection of different sizes as needed. A groove is provided on the inner wall of the lesion simulation shell 2, within which the radiation dosimeter 3 is installed.

[0029] The dosimeter channel 5 is fixed on the main container 1 and extends to the outside through the side wall of the main container 1. A through hole for the dosimeter channel 5 is opened on the lesion simulation shell 2. When fixing the lesion simulation shell 2, the through hole of the lesion simulation shell 2 is aligned with the dosimeter channel 5 and then inserted.

[0030] The lesion simulation shell 2 is made of rigid tissue equivalent material.

[0031] A through hole is made on the lesion simulation shell 2 for the drug inlet tube 6 and the drug outlet tube 7 to pass through. After the airbag is placed inside the lesion simulation shell 2, the drug inlet tube 6 and the drug outlet tube 7 are respectively passed through the through hole, and the outer wall of the drug inlet tube 6 is tightly fitted with the inner wall of the through hole, and the outer wall of the drug outlet tube 7 is tightly fitted with the inner wall of the through hole.

[0032] The inlet pipe 6, outlet pipe 7, water inlet pipe 8, and water outlet pipe 9 are flexible pipes. The flexible pipes can extend from the top of the main container 1 to the outside of the main container 1 and connect to external containers or devices to inject or discharge liquids.

[0033] A pure water contrast sphere 10 is placed inside the main container 1, and the pure water contrast sphere 10 is filled with pure water. In CT images, the pure water contrast sphere 10 is used as a base to compare the density difference of equivalent tissue materials relative to pure water, so as to ensure the accuracy of dose detection.

[0034] Adjustable switches are installed on the drug inlet pipe 6, drug outlet pipe 7, water inlet pipe 8, and water outlet pipe 9. These switches can be used to control the connection and disconnection of the drug inlet pipe 6, drug outlet pipe 7, water inlet pipe 8, and water outlet pipe 9, as well as the flow rate. By controlling the flow rate of the drug inlet pipe 6 and the drug outlet pipe 7, the metabolic rate of the radioactive solution by different patients or different tumors can be simulated.

[0035] Radiation dosimeters 3 are evenly distributed around the center of the lesion simulation shell 2, and are attached to the inner wall of the lesion simulation shell 2 or embedded in grooves on the inner wall of the lesion simulation shell 2. The radiation dosimeters 3 on the lesion simulation shell 2 can measure the radiation dose within the simulated lesion from all directions.

[0036] The present invention provides a method for measuring radiation dose of simulated intra-organ radiopharmaceutical metabolism, comprising the following steps.

[0037] a. Prepare a radiation dose measurement device for simulating intra-organ radiopharmaceutical metabolism. The device includes a main container 1, a lesion simulation shell 2, and a balloon 4. In use, the balloon 4 is located inside the lesion simulation shell 2, which is located inside the main container 1. Several radiation dosimeters 3 are distributed on the lesion simulation shell 2. A dosimeter channel 5 is provided on the lesion simulation shell 2. One end of the dosimeter channel 5 extends to the center of the lesion simulation shell 2, and the other end extends through the side wall of the main container 1 to the outside of the main container 1. A drug inlet tube 6 and a drug outlet tube 7 are connected to the balloon 4. A water inlet tube 8 and a water outlet tube 9 are provided on the lesion simulation shell 2.

[0038] The specific structure of the simulated organ radiopharmaceutical metabolism radiation dose measurement device is as described above and will not be repeated here. During preparation, a lesion simulation shell 2 of appropriate size is selected based on the size of the tumor to be simulated. The inner wall diameter of the lesion simulation shell 2 ranges from 2 to 10 cm, and several sizes of lesion simulation shell 2 can be prefabricated, such as making the diameter of each size differ by 1 cm. A lesion simulation shell 2 slightly larger than the tumor size is selected. The balloon 4, after being filled with water, has a maximum size equal to the inner wall size of the lesion simulation shell 2. A certain volume of liquid can be filled between the balloon 4 and the inner wall of the lesion simulation shell 2, so that the size of the balloon 4 is approximately the same as the size of the tumor to be simulated.

[0039] b. After annealing, fix the radiation dosimeter 3 to the inner wall of the lesion simulation shell 2, and then place the lesion simulation shell 2 in the center of the main container 1.

[0040] The lesion simulation shell 2 is fixed inside the main container 1 through the dosimeter channel 5. The dosimeter channel 5 and the side wall of the main container 1 are an integral structure. The end of the dosimeter channel 5 is located at the center of the main container 1. The end of the dosimeter channel 5 is inserted into the through hole on the lesion simulation shell 2, and the lesion simulation shell 2 is adjusted to be located at the center of the main container 1. At this time, the end of the dosimeter is exactly located at the center of the sphere of the lesion simulation shell 2.

[0041] After the lesion simulation shell 2 is placed inside the main container 1, solid tissue equivalent material is filled into the main container 1 to simulate the organ where the lesion is located.

[0042] c. Inject a mixture of radioactive solution and a fluid with the same density as the tumor into the balloon 4 through the inlet tube 6. After filling, close the inlet tube 6 and connect an infusion set containing saline to the port of the inlet tube 6.

[0043] The balloon 4 is a flexible balloon. During the process of the balloon 4 expanding when it is injected with liquid, it will deform accordingly when it encounters the dosimeter channel 5, thereby covering the dosimeter channel 5. When the balloon 4 is filled with liquid, the balloon 4 approximately forms a sphere. At this time, the end of the dosimeter channel 5 is located at the center of the balloon 4.

[0044] d. Place the radiation dosimeter 3 into the center of the balloon 4 along the dosimeter channel 5.

[0045] The radiation dosimeter 3 here can be a finger-shaped ionization chamber. The finger-shaped ionization chamber is placed at the innermost end of the dosimeter channel 5. At this time, the finger-shaped ionization chamber is located at the center of the balloon 4.

[0046] e. Perform a CT scan on the entire device to determine the density and relative positional relationship of each part. If it does not meet the requirements, make fine adjustments.

[0047] After obtaining CT images, the density and location of each part are determined by comparing the tissue equivalent material and the pure water contrast sphere 10 to ensure the accuracy of the density and location of each part. When the size of the balloon 4 does not meet the requirements, a liquid with the same density as the tumor is injected into the lesion simulation shell 2 through the water inlet pipe 8 to fine-tune the size of the balloon 4.

[0048] f. Begin measurement. Adjust the infusion rate on the infusion tube 6 according to the metabolic rate of the radioactive solution for different patients or different tumors. At the same time, open the regulating switch on the outflow tube 7 to ensure pressure balance inside the balloon 4.

[0049] After measuring for a period of time, the radiation dosimeter 3 is removed, and the radiation dose at the corresponding position of the balloon 4 is obtained and recorded.

[0050] Using the method of the present invention, the dose at the center or periphery of the balloon can be measured, and short doses at different times can be measured and recorded to obtain the cumulative dose over the entire decay cycle, thereby simulating the radiation dose of the lesion tumor.

[0051] This invention can also be used in conjunction with the applicant's prior application CN202110214053.3, which discloses an in vitro dose measurement device and method for radioactive particle implantation. The in vitro dose measurement device for radioactive particle implantation includes a fixed ring, with a dose measurement ring coaxially arranged at one end of the fixed ring. The fixed ring and the dose measurement ring are connected to each other via a distance adjustment mechanism, the distance between them being adjusted by the mechanism. Multiple fixed rods are arranged circumferentially on the fixed ring, with the length direction of the rods being the radius direction of the fixed ring. Several dosimeters are arranged circumferentially on the dose measurement ring, with the length direction of the dosimeters being the radius direction of the ring. A telescopic adjustment mechanism is provided on the dose measurement ring to adjust the telescopic range of all the dosimeters.

[0052] The radioactive particle implantation dosimetry device can be used to measure the three-dimensional dose distribution of a simulated lesion. After completing the above measurements, the fixing ring and the dose measurement ring are placed on the main container 1 of the invention, and the fixing rod is rotated to fix the main container 1 in the center of the fixing ring. The distance adjustment mechanism is used to adjust the distance between the dose measurement ring and the fixing ring so that the plane of the dosimeter on the dose measurement ring coincides with the plane to be measured. The telescopic adjustment mechanism is used to adjust the telescopic extension of the dosimeter so that the inner ends of all the dosimeters reach the position to be measured, and the dose at that position is measured. The distance adjustment mechanism and the telescopic adjustment mechanism are adjusted multiple times to measure different planes and different distances of the invention, and the measurement results and the corresponding measurement points of the dosimeters are recorded.

[0053] This invention provides a radiation dose measurement device for simulating intra-organ radiopharmaceutical metabolism. It simulates the metabolism of radiopharmaceuticals within an organ in vitro and obtains accurate radiation dose through measurement. The invention uses a lesion simulation shell 2 to simulate a lesion and a balloon 4 to simulate a tumor. Different sizes of lesion simulation shells 2 can be selected according to different lesion sizes. This invention supports the mixed application of multiple dosimeters to measure the dose at multiple specific points. In addition to radiation dosimeters 3 distributed on the lesion simulation shell 2, the radiation dosimeters 3 are also arranged in the center of the balloon 4 through dosimeter channels 5. The balloon 4 of this invention simulates drug concentration and metabolism in the tumor area by adjusting the flow rates of the inlet tube 6 and the outlet tube 7. A pure water contrast sphere 10 is used as a basis to compare the different density differences of various parts on CT images, further ensuring the accuracy of dose detection.

[0054] The advantages of using this invention are as follows: 1. It eliminates the need to predict the total activity or amount of radionuclide administered to the patient. 2. It can simulate the different metabolic rates of radionuclides in the organs where the lesion is located, making dose measurement more realistic and accurate. 3. It solves the problem of radionuclide loss during drug administration; dose detection is based on the actual radionuclide reaching the lesion. 4. The software of the radiation detection equipment can accurately represent the two-dimensional and three-dimensional dose distribution of the target lesion. 5. It can accurately assess the dose distribution of organs at risk around the target area. 6. By changing dose calculation to dose detection, the dose of radiation emitted by the radiation source can be directly measured using a dose detection device, resulting in objective and accurate results.

Claims

1. A device for measuring radiation dose in simulated intra-organ radiopharmaceutical metabolism, characterized in that, The device includes a main container filled with tissue equivalent material, a lesion simulation shell disposed within the main container, a plurality of radiation dosimeters distributed on the lesion simulation shell, a balloon disposed within the lesion simulation shell, a dosimeter channel disposed on the lesion simulation shell, one end of the dosimeter channel extending to the center of the lesion simulation shell and the other end extending outside the main container, a drug inlet tube and a drug outlet tube connected to the balloon, and a water inlet tube and a water outlet tube disposed on the lesion simulation shell. Adjustment switches are installed on the drug inlet tube, drug outlet tube, water inlet tube, and water outlet tube; a mixture of radioactive solution and a liquid with the same density as the tumor is injected into the balloon through the drug inlet tube; a liquid with the same density as the tumor is injected into the lesion simulation shell through the water inlet tube, so as to finely adjust the size of the balloon; The lesion simulation shell is formed by the joining of two hemispherical shell structures and is made of a rigid tissue equivalent material.

2. The device for measuring radiation dose of simulated intra-organ radiopharmaceutical metabolism according to claim 1, characterized in that, A pure water comparison ball is placed inside the main container, and the pure water comparison ball is filled with pure water.

3. The device for measuring radiation dose of simulated intra-organ radiopharmaceutical metabolism according to claim 1, characterized in that, The main container is cylindrical.

4. The device for measuring radiation dose of simulated intra-organ radiopharmaceutical metabolism according to claim 1, characterized in that, The radiation dosimeters are evenly distributed around the center of the lesion simulation shell.

5. A method for measuring radiation dose in simulated organ radiopharmaceutical metabolism, characterized in that, Includes the following steps: a. Prepare a device for measuring radiation dose of radiopharmaceutical metabolism in simulated organs. The device includes a main container, a lesion simulation shell, and a balloon. When in use, the balloon is located inside the lesion simulation shell, which is located inside the main container. Several radiation dosimeters are distributed on the lesion simulation shell. A dosimeter channel is provided on the lesion simulation shell. One end of the dosimeter channel extends to the center of the lesion simulation shell, and the other end extends through the side wall of the main container to the outside of the main container. A drug inlet tube and a drug outlet tube are connected to the balloon. A water inlet tube and a water outlet tube are provided on the lesion simulation shell. b. After annealing, fix the radiation dosimeter to the inner wall of the lesion simulation shell, and then place the lesion simulation shell in the center of the main container; c. Inject a mixture of radioactive solution and fluid with the same density as the tumor into the balloon through the inlet tube. After filling, close the inlet tube and connect an infusion set containing saline to the end of the inlet tube. d. Place the radiation dosimeter along the dosimeter channel into the center of the balloon; e. Perform a CT scan on the entire device to determine the density and relative position of each part. If it does not meet the requirements, make fine adjustments. Inject a liquid with the same density as the tumor into the lesion simulation shell through the water inlet pipe to fine-tune the size of the balloon. f. Begin measurement. Adjust the infusion rate on the infusion tube according to the metabolic rate of the radioactive solution for different patients or different tumors. At the same time, open the regulating switch on the outflow tube to ensure pressure balance inside the balloon. After measuring for a period of time, the radiation dosimeter is removed, and the radiation dose at the corresponding location of the balloon is obtained and recorded.

6. The method for measuring radiation dose in simulated organ radiopharmaceutical metabolism according to claim 5, characterized in that, Select a lesion simulation shell of appropriate size based on the size of the tumor to be simulated.

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