Computer-aided drug screening method based on FBXO2 and PKM2
By using computer-aided screening methods based on the binding sites of FBXO2 and PKM2, candidate drugs targeting the binding sites were screened, solving the problem of molecular heterogeneity in OSCC in existing technologies and achieving effective treatment for oral squamous cell carcinoma.
Patent Information
- Application Number
- CN202511810827.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-03
- Publication Date
- 2026-02-27
AI Technical Summary
Existing computer-aided drug screening methods lack multi-target synergistic effects assessment for the molecular heterogeneity of oral squamous cell carcinoma (OSCC), making it difficult to discover candidate drugs with combined therapeutic effects.
Based on the binding sites of FBXO2 and PKM2 proteins, computer-aided screening methods were used to identify candidate drugs targeting these binding sites, including small molecule compounds, protein analogs/antibodies/RNA drugs. Inhibitory activity experiments were then conducted to screen out compounds with inhibitory effects.
An effective computer-aided drug screening method is provided to screen for drugs that can inhibit the binding of FBXO2 and PKM2 for the treatment of oral squamous cell carcinoma, reducing side effects and improving treatment efficacy.