A fully automated immunoassay analyzer with easy loading and unloading

Abstract

A fully automated immunoassay analyzer with easy loading and unloading includes: a detection module (3); and a liquid dispensing module (1) and a loading module (2) disposed on the periphery of the detection module (3); wherein the liquid dispensing module (1) includes: a pull-out preparation drawer assembly (11); and a movable liquid dispensing assembly (12) disposed above the preparation drawer assembly (11); the preparation drawer assembly (11) includes: a base (111); a movable support frame (112) disposed above the base (111); a support seat (113) fixedly installed above the support frame (112); and a material tray (117) disposed above the support seat (113). According to the fully automated immunoassay analyzer, the material tray (117) can be moved to the outside of the instrument to facilitate the filling or removal of pipette tips in the material tray (117). At the same time, the movement process can be limited so that the pipette tips in the material tray (117) can move stably, preventing damage to the pipette tips and thus improving work efficiency.

Description

Technical Field

[0001] This invention relates to the field of point-of-care testing (POCT) for in vitro diagnostics. More specifically, this invention relates to a fully automated immunoassay analyzer that facilitates loading and unloading of samples. Background Technology

[0002] In the field of point-of-care testing (POCT) for in vitro diagnostics, it is well known that fluorescence immunoassay analyzers with different structural forms are used to achieve accurate and rapid sample detection. During the research and implementation of accurate and rapid sample detection, the inventors discovered that existing fluorescence immunoassay analyzers have at least the following problems:

[0003] Existing immunofluorescence analyzers have several problems: First, the existing support base is located inside the instrument, with the pipette tip tray positioned above it. When removing used pipette tips or refilling them, operators must reach inside the instrument, causing anxiety due to the internal moving parts and concerns about mechanical injury, or even personal injury due to improper operation or instrument malfunction. Second, the optical module in existing instruments, composed of multiple precision components and carefully selected lenses, plays a crucial role in data detection. Accumulated wear and tear on the instrument, as well as external environmental factors or changes, can affect the optical module, leading to inaccurate analysis results.

[0004] In view of this, it is necessary to develop a fully automated immunoassay analyzer that is easy to load and unload, in order to solve the above problems. Summary of the Invention

[0005] To address the shortcomings of existing technologies, the main objective of this invention is to provide a fully automated immunoassay analyzer that facilitates loading and unloading of materials. This analyzer can move the material tray to the outside of the instrument, making it easier to fill or remove pipette tips within the tray. Simultaneously, the movement process can be limited to ensure stable movement of the pipette tips within the tray, preventing damage to the pipette tips and thus improving work efficiency.

[0006] Another objective of this invention is to provide a fully automated immunoassay analyzer that facilitates loading and unloading. This analyzer uses an outer ring drive module to periodically control the calibrator to be positioned directly below the optical module, automatically calibrating the optical module. This process is safe, reliable, and stable, generates no consumables, saves costs, and eliminates the need for manual operation. The fully automated calibration process significantly improves work efficiency and has broad market application value.

[0007] To achieve these objectives and other advantages according to the present invention, a fully automated immunoassay analyzer with convenient loading and unloading is provided, comprising: a detection module; and

[0008] The liquid sampling module and the feeding module are located on the outer periphery of the detection module;

[0009] The liquid dispensing module includes: a pull-out preparation drawer assembly; and a movable liquid dispensing assembly disposed above the preparation drawer assembly.

[0010] The material preparation drawer assembly includes: a base;

[0011] A movable support frame located above the base;

[0012] A support base fixedly installed above the support frame; and

[0013] The material tray is located above the support base.

[0014] Preferably, the material preparation drawer assembly further includes: at least two limiting brackets, the two limiting brackets being mirror-image arranged in the horizontal direction, and defining a material pulling channel for the material tray between the two limiting brackets; and

[0015] A limiting block is located on the side of the limiting frame;

[0016] The limiting frame limits the material tray in the vertical direction, and the limiting block limits the material tray in the horizontal direction.

[0017] Preferably, each of the limiting frames has a limiting part at its top, and the limiting part at least partially overlaps with the projection of the material tray in the horizontal direction.

[0018] Preferably, a guide rail is provided between the support frame and the base, and the movable part of the support frame and the guide rail are connected in a driving connection.

[0019] Preferably, the support frame includes: a support portion; and

[0020] The material pulling part is integrally formed with the support part and extends in a direction perpendicular to the support part.

[0021] Preferably, the detection module includes: a support platform;

[0022] An outer ring and an inner ring are disposed on the support platform, both of which are rotatably connected to the support platform; and

[0023] Data processor;

[0024] An optical component is located above the support platform and is situated on the outer periphery of the outer ring. The optical component is wirelessly connected to the data processor. A calibration object is located at the top of the outer ring. The outer ring is driven to rotate by an outer ring drive module, which periodically drives the outer ring to rotate in the forward or reverse direction to control the calibration object to be positioned directly below the optical component.

[0025] Preferably, the optical component includes: a position fine adjuster, which is arranged in a horizontal direction;

[0026] The receiving frame is connected to the power output end of the position fine-tuner; and

[0027] An optical module is fixedly mounted on the surface of the support frame;

[0028] The position fine-tuner drives the optical module to reciprocate in the horizontal direction to fine-tune the position of the optical module.

[0029] Preferably, the optical module includes: a hollow fixed frame; and

[0030] A laser emitter, a dichroic mirror, a first lens, a filter, a second lens, a pinhole aperture, and a detector are disposed inside the fixed frame.

[0031] The first lens, dichroic mirror, filter, second lens, pinhole aperture, and detector are arranged vertically from bottom to top, and are coaxially arranged vertically. The laser emitter and the dichroic mirror are at the same height vertically. The dichroic mirror is tilted. The detector is wirelessly connected to the data processor.

[0032] Preferably, the outer ring includes a calibration section, the top of which has a positioning groove that is adapted to the calibration object, and the calibration object is placed in the positioning groove.

[0033] Preferably, the inner ring is embedded in the outer ring and is concentrically arranged with the outer ring. At least two stages are fixedly arranged on the outer ring. The support stage is provided with a test strip feeding station, a test strip box replacement station, and a fluorescence analysis station in sequence and at equal intervals along the circumferential direction of the inner ring. At least one test strip box is provided on the inner ring. The optical component is arranged at the fluorescence analysis station.

[0034] Preferably, a test strip holder is fixedly installed on the inner ring, and the lower half of the test strip box is detachably inserted into the test strip holder. The number of test strip holders corresponds to the number of test strip boxes.

[0035] One of the above technical solutions has the following advantages or beneficial effects: it can move the material tray to the outside of the instrument, which facilitates the filling or removal of the pipette tips in the material tray. At the same time, it can limit the movement process, so that the pipette tips in the material tray can move stably, preventing damage to the pipette tips, thereby improving work efficiency.

[0036] Another technical solution mentioned above has the following advantages or beneficial effects: By periodically controlling the calibration object to be located directly below the optical module through the outer ring drive module, the optical module is automatically calibrated. This is safe, reliable, and stable, with no consumables generated, saving costs and eliminating the need for manual operation. The calibration is completed fully automatically, with a high degree of automation, greatly improving work efficiency and having broad market application value.

[0037] Other advantages, objectives and features of the present invention will become apparent in part from the following description, and in part from those skilled in the art through study and practice of the invention. Attached Figure Description

[0038] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings of the embodiments will be briefly described below. Obviously, the drawings described below only relate to some embodiments of the present invention and are not intended to limit the present invention, wherein:

[0039] Figure 1 A three-dimensional structural view of a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention;

[0040] Figure 2 A three-dimensional structural view of the liquid collection module and the loading module in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention;

[0041] Figure 3 A three-dimensional structural view of the material preparation drawer assembly in a fully automated immunoassay analyzer with convenient loading and unloading according to an embodiment of the present invention;

[0042] Figure 4 An exploded structural view of the material preparation drawer assembly in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention;

[0043] Figure 5 An exploded top view of the material preparation drawer assembly in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention;

[0044] Figure 6 A three-dimensional structural view of the detection module in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention;

[0045] Figure 7 A top view of the detection module in a fully automated immunoassay analyzer with easy loading and unloading according to an embodiment of the present invention;

[0046] Figure 8 A three-dimensional structural view of the optical components in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention;

[0047] Figure 9 This is a partially exploded cross-sectional view of the optical module and outer ring in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention.

[0048] Figure 10 This is a partial cross-sectional view of the optical module and outer ring in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention.

[0049] Figure 11 This is a partial cross-sectional view of the optical module and outer ring in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention.

[0050] Figure 12 This is a front view of the test strip box and test strip box holder in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention.

[0051] Figure 13 A three-dimensional structural view of the test strip box and test strip box holder in a fully automated immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention.

[0052] Figure 14 This is a flowchart illustrating the operation of a fully automated immunoassay analyzer for easy loading and unloading according to one embodiment of the present invention. Detailed Implementation

[0053] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0054] In the accompanying drawings, shapes and dimensions may be enlarged for clarity, and the same reference numerals will be used in all figures to indicate the same or similar parts.

[0055] Unless otherwise defined, the technical or scientific terms used herein should have the ordinary meaning understood by one of ordinary skill in the art to which this invention pertains. The terms “first,” “second,” and similar terms used in this patent application specification and claims do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Similarly, the terms “an,” “a,” or “the,” and similar terms do not indicate a quantity limitation, but rather indicate the presence of at least one. The terms “comprising,” “including,” and similar terms mean that the elements or objects preceding “comprising” or “including” encompass the elements or objects listed following “comprising” or “including” and their equivalents, but do not exclude other elements or objects. The terms “upper,” “lower,” “left,” and “right,” etc., are used only to indicate relative positional relationships; when the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0056] In the following description, terms such as center, thickness, height, length, front, back, rear, left, right, top, bottom, upper, and lower are defined relative to the structure shown in the accompanying drawings. In particular, "height" corresponds to the dimension from top to bottom, "width" corresponds to the dimension from left to right, and "depth" corresponds to the dimension from front to back. These are relative concepts and may vary depending on their location and usage. Therefore, these or other orientations should not be interpreted as restrictive terms.

[0057] Terms involving attachment, connection, etc. (e.g., “connection” and “attachment”) refer to the relationship in which these structures are directly or indirectly fixed or attached to each other through an intermediate structure, and to the relationship of movable or rigid attachment, unless otherwise explicitly stated.

[0058] According to one embodiment of the present invention, Figures 1-11 As shown in the diagram, the fully automated immunoassay analyzer, which facilitates loading and unloading, includes: a detection module 3; and

[0059] Liquid collection module 1 and feeding module 2 are located on the outer periphery of the detection module 3;

[0060] The liquid dispensing module 1 includes: a pull-out material preparation drawer assembly 11; and a movable liquid dispensing assembly 12 disposed above the material preparation drawer assembly 11.

[0061] The material preparation drawer assembly 11 includes: a base 111;

[0062] A movable support frame 112 is provided above the base 111;

[0063] The support base 113 is fixedly installed above the support frame 112; and

[0064] The material tray 117 is located above the support base 113.

[0065] In a preferred embodiment, the tray 117 includes: a support portion 1171;

[0066] At least two upper limit portions 1172 are integrally formed with the support portion 1171 and extend upward in a direction perpendicular to the support portion 1171.

[0067] At least two lower limit portions 1173 are integrally formed with the support portion 1171 and extend downward in a direction perpendicular to the support portion 1171.

[0068] The pipette tip is placed above the support portion 1171, and the tray 117 is placed above the support portion 113 by the cooperation of the lower limiting portion 1173 and the support base 113.

[0069] Furthermore, the material preparation drawer assembly 11 further includes: at least two limiting brackets 114, the two limiting brackets 114 being mirror images of each other in the horizontal direction, and defining a material pulling channel for the material tray 117 between the two limiting brackets 114; and

[0070] A limiting block 115 is disposed on the side of the limiting frame 114;

[0071] The limiting frame 114 limits the material tray 117 in the vertical direction, and the limiting block 115 limits the material tray 117 in the horizontal direction.

[0072] Furthermore, each of the limiting frames 114 is provided with a limiting part 1141 at its top end, and the limiting part 1141 at least partially overlaps with the projection of the material tray 117 in the horizontal direction.

[0073] Understandably, the limiting part 1141 cooperates with the upper limiting part 1172 to limit the material tray 117 in the vertical direction.

[0074] Furthermore, a guide rail 116 is provided between the support frame 112 and the base 111, and the movable part of the support frame 112 and the guide rail 116 are connected in a transmission manner; the guide rail 116 guides the material tray 117.

[0075] Furthermore, the support frame 112 includes: a support portion 1121; and

[0076] The material pulling part 1122 is integrally formed with the supporting part 1121 and extends in a direction perpendicular to the supporting part 1121.

[0077] In a preferred embodiment, the support frame 112 further includes a sensing part 1123, which is integrally formed with the support part 1121 and extends downward in a direction perpendicular to the support part 1121;

[0078] The base 111 is provided with a position sensor 118, and the sensing unit 1123 cooperates with the position sensor 118 to monitor whether the support 113 is reset.

[0079] The material preparation drawer assembly 11 further includes an elastic reset device 119, the movable part of which is fixedly connected to the support part 1121. The elastic reset device 119 is provided to facilitate resetting the support base 113 after it is pulled out and to lock the support base 113.

[0080] The working process of the preparation drawer assembly 11 is as follows: when filling or removing the pipette tip, the operator pulls out the support base 113 through the material pulling part 1122, and then pulls out the material tray 117, so that the material tray 117 moves to the outside of the instrument, so as to fill or remove the pipette tip.

[0081] When the pipette tip is filled, push the support base 113 in. First, the limit bracket 114 restricts the vertical direction of the support base 113, preventing it from wobbling up and down. The limit block 115 restricts the horizontal direction of the support base 113, preventing it from wobbling left and right. Finally, push the support base 113 to the bottom and lock it through the elastic reset device 119, preventing it from moving back and forth. The support base 113 is then fully positioned.

[0082] In a preferred embodiment, the mobile liquid collection assembly 12 includes: a mobile drive module 121; and a liquid collection tube 122 that is pulsatorically connected to the mobile drive module 121.

[0083] The mobile drive module 121 drives the liquid collection tube 122 to reciprocate along the X-axis, Y-axis and Z-axis directions respectively.

[0084] In a preferred embodiment, the mobile drive module 121 includes: an X-axis driver 1211;

[0085] Y-axis actuator 1212, which is drively connected to X-axis actuator 1211; and

[0086] Z-axis driver 1213 is drive-connected to Y-axis driver 1212;

[0087] The liquid collection tube 122 is connected to the Z-axis driver 1213 in a transmission connection;

[0088] The X-axis actuator 1211 drives the liquid collection tube 122 to reciprocate along the X-axis direction, the Y-axis actuator 1212 drives the liquid collection tube 122 to reciprocate along the Y-axis direction, and the Z-axis actuator 1213 drives the liquid collection tube 122 to reciprocate along the Z-axis direction.

[0089] The working process of the mobile liquid-collecting assembly 12 is as follows: the X-axis actuator 1211 and the Y-axis actuator 1212 drive the liquid-collecting tube 122 to move directly above the material tray 117; the Z-axis actuator 1213 drives the liquid-collecting tube 122 to move downward along the Z-axis to obtain the pipette tip from the material tray 117, and assembles the pipette tip with the liquid-collecting tube 122 into one unit; the X-axis actuator 1211 and the Y-axis actuator 1212 drive the liquid-collecting tube 122 to move directly above the feeding module 2; the Z-axis actuator 1213 drives the liquid-collecting tube 122 to move downward along the Z-axis to obtain the liquid to be tested from the feeding module 2; the pipette tip obtains the liquid... After the liquid is taken, the X-axis actuator 1211 and the Y-axis actuator 1212 drive the liquid taking tube 122 to move directly above the test strip replacement station 312. The Z-axis actuator 1213 drives the liquid taking tube 122 to move downward along the Z-axis to drop the liquid in the pipette tip onto the test strip located at the test strip replacement station 312 for detection. The X-axis actuator 1211 and the Y-axis actuator 1212 drive the liquid taking tube 122 to move directly above the tray 117. The Z-axis actuator 1213 drives the liquid taking tube 122 to move downward along the Z-axis to place the pipette tip after liquid taking inside the tray 117, and then retrieve the pipette tip again, repeating the above steps.

[0090] Furthermore, the detection module 3 includes: a support platform 31;

[0091] An outer ring 32 and an inner ring 35 are disposed on the support platform 31, both of which are rotatably connected to the support platform 31; and

[0092] Data processor;

[0093] An optical component 33 is provided above the support platform 31. The optical component 33 is located on the outer periphery of the outer ring 32 and is wirelessly connected to the data processor. A calibration object 34 is provided at the top of the outer ring 32. The outer ring 32 is driven to rotate by an outer ring drive module. The outer ring drive module periodically drives the outer ring 32 to rotate in the forward or reverse direction to control the calibration object 34 to be located directly below the optical component 33.

[0094] In a preferred embodiment, the calibrator 34 is ruby, which contains Cr element and can undergo electronic transitions when excited by a laser of a specific wavelength.

[0095] The data processor is a tablet computer.

[0096] Furthermore, the optical component 33 includes: a position fine adjuster 331, which is arranged in a horizontal direction;

[0097] The receiving frame 332 is drive-connected to the power output end of the position fine-tuner 331; and

[0098] An optical module 333 is fixedly mounted on the surface of the support frame 332;

[0099] The position fine-tuner 331 drives the optical module 333 to reciprocate in the horizontal direction to fine-tune the position of the optical module 333.

[0100] Furthermore, the optical module 333 includes: a hollow fixed frame 3331; and

[0101] The laser emitter 3332, dichroic mirror 3333, first lens 3334, filter 3335, second lens 3336, pinhole aperture 3337 and detector 3338 are disposed inside the fixed frame 3331.

[0102] The first lens 3334, dichroic mirror 3333, filter 3335, second lens 3336, pinhole aperture 3337, and detector 3338 are arranged vertically from bottom to top, and are coaxially arranged vertically. The laser emitter 3332 and the dichroic mirror 3333 are at the same height vertically. The dichroic mirror 3333 is tilted. The detector 3338 is wirelessly connected to the data processor.

[0103] Furthermore, the outer ring 32 includes a calibration part 321, and a positioning groove 3211 is provided at the top of the calibration part 321. The positioning groove 3211 is adapted to the calibration object 34, and the calibration object 34 is placed in the positioning groove 3211.

[0104] In a preferred embodiment, the calibration unit 321 has a fluorescence focusing groove 3212 inside, the fluorescence focusing groove 3212 is located directly below the positioning groove 3211, the cross-section of the fluorescence focusing groove 3212 is arc-shaped, and the surface of the fluorescence focusing groove 3212 is smooth.

[0105] Understandably, when a ruby ​​is excited to fluoresce, its fluorescence is three-dimensional. Traditional methods of capturing fluorescence only use a lens to collect it from one side of the ruby, resulting in poor collection efficiency and the inability to effectively collect most of the fluorescence.

[0106] The present invention provides a fluorescence focusing groove 3212 directly below the positioning groove 3211 where the ruby ​​is placed. At the same time, the surface of the fluorescence focusing groove 3212 is polished so that the fluorescence emitted from the lower end face of the ruby ​​is immediately refracted after contacting the polished surface of the fluorescence focusing groove 3212, and focused at a point with the fluorescence emitted from the upper end face of the ruby. This greatly reduces the dissipation of fluorescence in other directions and amplifies the fluorescence signal by increasing the collection surface area.

[0107] In a preferred embodiment of the present invention, the optical component 33 further includes an alarm, which is wirelessly connected to the data processor.

[0108] Understandably, when the optical component 33 undergoes multiple automatic calibrations, the data processor controls the alarm to sound an alarm, reminding staff to perform manual calibration.

[0109] The calibration process of the optical module 333 is as follows: the outer ring drive module periodically drives the outer ring 32 to rotate in the forward or reverse direction to control the calibration object 34 to be located directly below the optical module 333. The laser emitter 3332 emits excitation light, which is refracted by the dichroic mirror 3333 and focused onto the ruby ​​by the first lens 3334. The ruby ​​is excited to emit fluorescence, which is focused and collected by the fluorescence focusing groove 3212 to the focal point of the first lens 3334. After passing through the first lens 3334, it passes parallel to the dichroic mirror 3333, the filter 3335, the second lens 3336, and the pinhole aperture 3337 before reaching the detector 3338. The detector 3338 reads the fluorescence data and uploads the data to the data processor. The data processor performs data information analysis, comparison, and parameter correction to calibrate the optical module 333.

[0110] Furthermore, combined again Figure 6 and Figure 7 The inner ring 35 is embedded in the outer ring 32 and is concentric with the outer ring 32. At least two stages 322 are fixedly provided on the outer ring 32. The support stage 31 is provided with a test strip feeding station 311, a test strip box replacement station 312, and a fluorescence analysis station 313 in sequence and at equal intervals along the circumferential direction of the inner ring 35. At least one test strip box 36 is provided on the inner ring 35. The optical component 33 is provided at the fluorescence analysis station 313.

[0111] In a preferred embodiment, the outer periphery of the inner ring 35 slides in contact with the inner periphery of the outer ring 32, thereby enabling smooth and stable relative rotation between the inner ring 35 and the outer ring 32.

[0112] Furthermore, combined again Figure 6 and Figure 7 A test strip holder 38 is fixedly installed on the inner ring 35. The lower half of the test strip box 36 is detachably inserted into the test strip holder 38. The number of test strip holders 38 corresponds to the number of test strip boxes 36.

[0113] Furthermore, combined with Figure 12 and Figure 13 The test strip holder 38 has a test strip ejection port 381 extending through its front and rear sides at its base, and the test strip box 36 has a test strip self-drop groove 361 at its bottom that is connected to the test strip ejection port 381.

[0114] Furthermore, the front side of the test strip holder 38 is provided with a left guide seat 382 and a right guide seat 383 located on the left and right sides of the test strip ejection port 381, respectively. The left guide seat 382 and the right guide seat 383 are respectively provided with a left guide groove 3821 and a right guide groove 3831 arranged opposite to each other. The surfaces of the left guide groove 3821 and the right guide groove 3831 are on the same horizontal plane as the bottom surface of the test strip drop groove 361, so that the test strip ejected from the test strip drop groove 361 can be smoothly received by the left guide groove 3821 and the right guide groove 3831 and guided into the test strip carrier for subsequent liquid dispensing operation.

[0115] In a preferred embodiment, the test strip box 36 is provided with three strips at equal intervals in the circumferential direction of the inner ring 35.

[0116] The inner ring 35 is driven to rotate by the inner ring drive module. The support platform 31 is also provided with a test paper ejection unit. The inner ring 35 has an inner ring angle sensor 351 for sensing the rotation angle of the inner ring 35.

[0117] Each test strip box 36 has a buffer plate 37 on its side.

[0118] The clockwise or counterclockwise rotation of the outer ring 32 and the inner ring 35 does not affect the specific implementation of the technical solution in this invention. Here, the counterclockwise rotation of the outer ring 32 and the inner ring 35 is used as an example for detailed explanation.

[0119] Immunofluorescence analysis steps:

[0120] First, the inner ring 35 is rotated so that one of the test strip boxes 36 on it is rotated to the test strip feeding station 311. The other two test strip boxes 36 on the inner ring 35 are located at the test strip box replacement station 312 and the fluorescence analysis station 313, respectively. At the same time, the outer ring drive module drives the outer ring 32 so that one of its test strip slots is aligned with the test strip ejection port 381. The test strip ejection unit pushes outward so that the bottom test strip in the test strip box 36 on the test strip feeding station 311 is pushed into the test strip slot.

[0121] Next, drive the outer ring 32 to rotate counterclockwise by one test strip carrier station, so that the next test strip carrier is connected to the test strip ejection port 381, while the previous test strip carrier rotates the previous test strip to the side of the buffer plate 37. At this time, the robot arm sequentially adds the blood sample, buffer solution and fluorescently labeled antibody solution to the previous test strip.

[0122] Furthermore, the outer ring 32 rotates counterclockwise continuously and intermittently, causing the first test strip carrying the blood sample to rotate to the fluorescence analysis station 313 to receive fluorescence analysis by the optical component 33. After the first test strip has completed analysis, the outer ring 32 continues to rotate counterclockwise to the waste disposal station. With the assistance of the robotic arm, the analyzed test strips are collected and processed. This cycle is repeated until all the collected blood samples have been analyzed.

[0123] In the aforementioned immunofluorescence analysis step, when the test strips in the test strip cassette 36 at the test strip feeding station 311 are exhausted, the inner ring 35 rotates 120°, causing the test strip cassette 36 at the fluorescence analysis station 313 to rotate to the test strip feeding station 311, the test strip cassette 36 at the test strip replacement station 312 to rotate to the fluorescence analysis station 313, and the test strip cassette 36 at the test strip feeding station 311 to rotate to the test strip replacement station 312. This allows the replacement of full / empty test strip cassettes 36 to be performed at the test strip replacement station 312, greatly shortening the replacement time of the test strip cassette 36 and improving the analysis efficiency.

[0124] In summary, the workflow of this invention is as follows:

[0125] Upon power-on, the fully automated immunoassay analyzer performs self-testing and initialization. The optical module 333 performs automatic calibration. The sample tube is placed on the loading module 2, and the sample testing mode is activated. The liquid dispensing component 12 moves above the preparation drawer component 11, automatically assembles the pipette tip, moves above the sample tube to draw up the sample liquid, and then moves above the buffer solution plate 37, puncturing the membrane of the buffer solution plate 37 to continuously aspirate and mix the sample liquid with the buffer solution. Simultaneously, the inner ring drive module drives the test strip box 36 to rotate to the test strip feeding station 311, and the outer ring drive module drives the outer ring 32 so that one of its test strip slots aligns with the test strip feeding station. With the test strip ejection port 381 facing each other, the test strip ejection unit pushes the bottom test strip in the test strip box 36 on the test strip feeding station 311 into the test strip carrier. The moving liquid-taking component 12 draws the mixed solution to the test strip position on the test strip feeding station 311 for sample addition. The outer ring 32 continues to rotate, so that the test strip carrying the mixed solution rotates to the fluorescence analysis station 313 to receive fluorescence analysis by the optical component 33. When the test strip has completed the analysis, the outer ring 32 continues to rotate counterclockwise to the waste disposal station, where the analyzed test strips are collected and recycled. The moving liquid-taking component 12 moves to the top of the preparation drawer component to discard the pipette tip and enter the next cycle.

[0126] The number of devices and processing scale described herein are for the purpose of simplifying the description of the invention. Applications, modifications, and variations of the invention will be readily apparent to those skilled in the art.

[0127] Although embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and embodiments. It can be applied to various fields suitable for the present invention. Other modifications can be readily made by those skilled in the art. Therefore, without departing from the general concept defined by the claims and their equivalents, the present invention is not limited to the specific details and examples shown and described herein.

Claims

1. A full-automatic immune analyzer facilitating feeding and discharging, characterized in that, The utility model relates to a kind of detection module (3);And liquid taking module (1) and upper feeding module (2) are arranged in the periphery of the detection module (3); Wherein, the liquid taking module (1) includes: the material preparation drawer assembly (11) that can be pulled out;And mobile liquid taking assembly (12) is arranged in the upper of the material preparation drawer assembly (11); The material preparation drawer assembly (11) includes: base (111);Support frame (112) is movably arranged on the upper of the base (111);Support seat (113) is fixedly installed on the upper of the support frame (112);And tray (117), which is arranged on the upper of the support seat (113); The detection module (3) includes: Supporting table (31); Outer ring (32) and inner ring (35) are arranged on the supporting table (31), and the outer ring (32) and the inner ring (35) are rotatably connected with the supporting table (31); The upper of the supporting table (31) is provided with optical assembly (33), and the optical assembly (33) is located on the periphery of the outer ring (32);The top of the outer ring (32) is provided with calibration object (34), and the outer ring (32) is driven to rotate by outer ring driving module, and the outer ring driving module periodically drives the outer ring (32) to rotate in forward direction or reverse direction, to control the calibration object (34) to be located directly below the optical assembly (33), and the calibration object (34) is ruby; The outer ring (32) includes calibration part (321), the top of the calibration part (321) is provided with positioning groove (3211), and the calibration part (321) is provided with fluorescent focusing groove (3212) inside;The positioning groove (3211) is matched with the calibration object (34), and the calibration object (34) is placed in the positioning groove (3211);The fluorescent focusing groove (3212) is located directly below the positioning groove (3211), the cross section of the fluorescent focusing groove (3212) is circular arc type, and the surface of the fluorescent focusing groove (3212) is treated as light surface; The inner ring (35) is embedded in the outer ring (32) and is concentrically arranged with the outer ring (32), at least two object tables (322) are fixedly arranged on the outer ring (32), the supporting table (31) is sequentially and equidistantly provided with test paper unloading station (311), test paper box replacement station (312) and fluorescence analysis station (313) along the circumferential direction of the inner ring (35), and at least one test paper box (36) is arranged on the inner ring (35), and the optical assembly (33) is arranged in the fluorescence analysis station (313); The optical assembly (33) includes: Position fine adjuster (331) is arranged along horizontal direction; Support frame (332) is drivingly connected with the power output end of the position fine adjuster (331);And Optical module (333) is fixedly installed on the surface of the support frame (332); Wherein, the position fine adjuster (331) drives the optical module (333) to reciprocate along horizontal direction, so as to fine adjust the position of the optical module (333). ​ ​ ​ 2. The full-automatic immunoassay analyzer convenient for feeding and discharging according to claim 1, characterized in that, The material preparation drawer assembly (11) further comprises: at least two limiting racks (114), the two limiting racks (114) are mirror arranged along the horizontal direction, and a material disc (117) pulling channel is defined between the two limiting racks (114); and A limiting block (115) is arranged beside the limiting rack (114). The limiting rack (114) limits the material disc (117) along the vertical direction, and the limiting block (115) limits the material disc (117) along the horizontal direction.

3. The full-automatic immunoassay analyzer convenient for feeding and discharging according to claim 2, characterized in that, A limiting part (1141) is arranged at the top end of each limiting rack (114), and the limiting part (1141) at least partially overlaps with the projection of the material disc (117) in the horizontal direction.

4. The full-automatic immunoassay analyzer convenient for feeding and discharging according to claim 1, characterized in that, A guide rail (116) is arranged between the supporting rack (112) and the base (111), and the supporting rack (112) is in transmission connection with the movable part of the guide rail (116).

5. The full-automatic immunoassay analyzer convenient for feeding and discharging according to claim 1, characterized in that, The detection module (3) further comprises: A data processor; The optical assembly (33) is in wireless connection with the data processor.

6. The full-automatic immunoassay analyzer convenient for feeding and discharging according to claim 5, characterized in that, The optical module (333) comprises: an internal hollow fixed frame (3331); and A laser emitter (3332), a dichroic mirror (3333), a first lens (3334), a filter (3335), a second lens (3336), a pinhole diaphragm (3337) and a detector (3338) arranged inside the fixed frame (3331); The first lens (3334), the dichroic mirror (3333), the filter (3335), the second lens (3336), the pinhole diaphragm (3337) and the detector (3338) are sequentially arranged along the vertical direction from bottom to top, and the first lens (3334), the dichroic mirror (3333), the filter (3335), the second lens (3336), the pinhole diaphragm (3337) and the detector (3338) are coaxially arranged along the vertical direction, the laser emitter (3332) and the dichroic mirror (3333) are located at the same height along the vertical direction, the dichroic mirror (3333) is obliquely arranged, and the detector (3338) is in wireless connection with the data processor.

7. The full-automatic immunoassay analyzer convenient for feeding and discharging according to claim 1, characterized in that, A test paper box seat (38) is fixedly installed on the inner ring (35), and the lower half of the test paper box (36) is detachably inserted into the test paper box seat (38), and the number of the test paper box seat (38) corresponds to the number of the test paper box (36).

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