An artificial blood vessel coating device and method

Abstract

The present invention discloses an artificial blood vessel coating device and method, which relates to the field of artificial blood vessel repair and includes two parts: a pressurized coating system and a control system. The pressurized coating system includes a direct pipe joint for clamping the artificial blood vessel, a lifting plate, a guide rod, a liquid supply pump, a liquid return pump, a pressure stabilizing tank, a pressure sensor, a liquid storage tank, and a heating device. The direct pipe joint for clamping the artificial blood vessel is installed on the guide plate, and the guide plate is installed on the guide rod and can move up and down. The liquid supply pump and the liquid return pump form a pressure applying device to achieve impregnation perfusion coating of the artificial blood vessel under a certain pressure / perfusion coating under a certain pressure. The control system can set the pressure value, coating time, and heating temperature during coating. The present invention ensures that the coating liquid can penetrate into the internal pores of the fabric yarns through the pressurized coating method, ensures the sealing of the artificial blood vessel after coating, and improves the success rate of blood vessel transplantation surgery.

Description

Technical Field

[0001] The present invention relates to the field of artificial blood vessel repair, and particularly to an artificial blood vessel coating device and method. Background Art

[0002] Cardiovascular diseases are common diseases threatening human health, and their incidence rates rank first among various diseases. With the continuous acceleration of the aging process of China's population, the incidence rates and mortality rates of such diseases are increasing continuously, resulting in an increasing annual demand for artificial blood vessels.

[0003] Large-diameter artificial blood vessels are relatively mature in the market, and many domestic enterprises and institutions are researching and developing large-diameter artificial blood vessels, among which textile artificial blood vessels are one kind. However, textile artificial blood vessels have pores to varying degrees. When the artificial blood vessels filled with pores are implanted into the human body, a large amount of blood can leak from the blood vessel wall to the tissue space, and pre-coagulation or coating treatment must be carried out before transplantation. At present, there is no existing artificial blood vessel coating device in the market. Patent CN111068113 involves an artificial blood vessel coating preparation device, but its disadvantages are as follows: the peristaltic pump is pulsed and cannot ensure the stability of the coating pressure. For textile multi-porous artificial blood vessels, the leakage volume before coating is about 300 ml / cm 2 ·min, and the initial leakage volume is relatively large, so pressurized coating cannot be achieved. In addition, this device cannot heat the coating liquid, and it is not suitable to use this device for coating gelatin-based coating solutions that need to be heated. Summary of the Invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the present invention provides an artificial blood vessel coating device, which effectively solves the problems mentioned in the above technical background. The technical solution of the present invention is as follows:

[0005] An artificial blood vessel coating device includes a control system and a pressurized coating system;

[0006] The control system is electrically connected to the pressurized coating system and is used to set and control the coating pressure value, coating time, and coating liquid heating temperature of the pressurized coating system;

[0007] The pressurized coating system includes a base;

[0008] A liquid supply pump, a liquid return pump, a first pressure stabilizing tank, a second pressure stabilizing tank, and a heating device are respectively fixed on the base;

[0009] A first pressure sensor and a second pressure sensor are respectively installed on the first pressure stabilizing tank and the second pressure stabilizing tank;

[0010] A liquid storage tank is arranged on the heating device and is used to heat the coating liquid inside the liquid storage tank;

[0011] Inside the liquid storage tank, a first straight pipe joint and a second straight pipe joint are provided for clamping both ends of the artificial blood vessel.

[0012] The liquid supply pump, the first pressure stabilizing tank, and the first straight pipe joint are sequentially connected by hoses; the second straight pipe joint, the second pressure stabilizing tank, the liquid return pump, and the liquid storage tank are sequentially connected by hoses.

[0013] The first pressure stabilizing tank is connected to the liquid supply pump and the first straight pipe joint by a hose, which can stabilize the pressure of the artificial blood vessel coating on the liquid supply side. The second pressure stabilizing tank is connected to the liquid return pump and the second straight pipe joint by a hose, which can stabilize the pressure of the artificial blood vessel coating on the liquid return pump side, and control the artificial blood vessel to always be within the set pressure range during the coating process.

[0014] Preferably, a first guide rod and a second guide rod are fixedly installed on the base.

[0015] The lifting plate is installed on the first guide rod and the second guide rod through a first fixing ring and a second fixing ring. The first fixing ring and the second fixing ring can move up and down on the first guide rod and the second guide rod respectively, thereby driving the lifting plate to move up and down.

[0016] The lifting plate is of an L-shaped structure, with round holes at both ends. The first straight pipe joint and the second straight pipe joint are installed on the lifting plate through the round holes.

[0017] Preferably, the diameters of the first straight pipe joint and the second straight pipe joint are adjustable, and the adjustable range is 6mm - 32mm, which can be connected to artificial blood vessels of different diameters.

[0018] Preferably, a drain port is provided on the liquid storage tank for discharging the coating liquid.

[0019] Preferably, the feed hole of the first pressure stabilizing tank and the discharge hole of the second pressure stabilizing tank are located at the bottom of the tank body, and the hoses are connected to the pressure stabilizing tank through the feed hole and the discharge hole.

[0020] Preferably, the liquid supply pump can rotate in both forward and reverse directions. After the artificial blood vessel is removed at the end of the coating, the liquid supply pump rotates in the reverse direction, and the liquid return pump rotates in the forward direction to pump the coating solution inside the first pressure stabilizing tank and the second pressure stabilizing tank back into the liquid storage tank, emptying the coating liquid in the pressure stabilizing tank, and realizing the heating and reuse of the coating liquid.

[0021] Preferably, a PLC controller is provided in the control system. The coating pressure value, coating time, and coating liquid heating temperature can be set. The pressure sensor on the pressure stabilizing tank real-time detects the pressure difference at both ends of the artificial blood vessel, and feeds the detection result back to the control system. The control system realizes the set pressure value by adjusting the rotation speeds of the two pumps.

[0022] Preferably, the liquid supply pump and the liquid return pump are screw pumps or gear pumps.

[0023] Preferably, the first straight pipe joint and the second straight pipe joint are compression sleeve type taper thread straight pipe joints.

[0024] The present invention has the following advantages:

[0025] 1. The diameter of the straight pipe joint for clamping the artificial blood vessel is adjustable, and it can coat artificial blood vessels of any diameter; the tooling for clamping the artificial blood vessel has a lifting function and can achieve dip coating / perfusion coating under a certain pressure.

[0026] 2. The pressure during coating is stable and controllable, ensuring that the coating liquid can penetrate into the pores of the fabric yarns and not just float on the surface of the fabric.

[0027] 3. It has a heating function and can heat the coating liquid that needs to be heated and insulated, effectively solving the problem that gelatin-based coatings cannot be coated due to cooling and solidification during use.

[0028] 4. By replacing the coating liquid with water or blood, it can be used as a device for detecting the water seepage of artificial blood vessels.

[0029] 5. The equipment is simple to assemble and convenient to operate. Description of the Drawings

[0030] Figure 1 is a schematic diagram of the overall structure of the artificial blood vessel coating device of the present invention;

[0031] Figure 2 is a schematic diagram of the structure of the pressure coating system of the artificial blood vessel coating device of the present invention;

[0032] Figure 3 is a schematic diagram of the structure of the pressure coating system of the artificial blood vessel coating device of the present invention from another perspective;

[0033] Figure 4 is a schematic diagram of the water seepage test structure of the artificial blood vessel coating device of the present invention;

[0034] In the figure: 1 control system; 2 pressure coating system; 2-1 base; 2-2 liquid supply pump; 2-3 first pressure stabilizing tank; 2-4 first pressure sensor; 2-5 first straight pipe joint; 2-6 artificial blood vessel; 2-7 second straight pipe joint; 2-8 second pressure sensor; 2-9 second pressure stabilizing tank; 2-10 return liquid pump; 2-11 heating device; 2-12 drain port; 2-13 liquid storage tank; 2-14 first guide rod; 2-15 first fixing ring; 2-16 lifting plate; 2-17 second guide rod; 2-18 second fixing ring; 2-19 water seepage collection box. Detailed Embodiments Embodiment

[0035] An artificial blood vessel coating device includes a control system 1. The control system 1 is electrically connected to a pressurized coating system 2 and is used to set and regulate the coating pressure value, coating time, and heating temperature of the coating liquid. The pressurized coating system 2 includes a base 2-1, a liquid supply pump 2-2, a liquid return pump 2-10, a first pressure stabilizing tank 2-3, a second pressure stabilizing tank 2-9, and a heating device 2-11 which are respectively fixed on the base 2-1. The liquid supply pump 2-2 is used to introduce the coating liquid into the artificial blood vessel 2-6 to be coated, and the liquid return pump 2-10 is used to introduce the coating liquid in the artificial blood vessel 2-6 into the liquid storage tank 2-13. To achieve the stability of the coating pressure, the liquid supply pump and the liquid return pump are preferably screw pumps or gear pumps. A first pressure sensor 2-4 and a second pressure sensor 2-8 are respectively installed on the first pressure stabilizing tank 2-3 and the second pressure stabilizing tank 2-9. The first pressure sensor 2-4 and the first pressure stabilizing tank 2-3 are used to monitor and stabilize the pressure value at the end of the liquid supply pump 2-2, and the second pressure sensor 9 and the second pressure stabilizing tank 10 are used to monitor and stabilize the pressure value at the end of the liquid return pump 2-10. The pressure sensors 2-4 and 2-8 feedback the monitored signals to the control system 1, and the control system 1 realizes constant pressure coating at a certain pressure by regulating the rotation speeds of the liquid supply pump 2-2 and the liquid return pump 2-10. A first straight pipe joint 2-5 and a second straight pipe joint 2-7 are installed on the lifting plate 2-16. The joints are preferably ferrule type taper thread straight pipe joints, which can firmly connect the artificial blood vessel 2-6 to the hose, prevent liquid leakage at the joints, and better ensure the stability of the pressure during coating. The lifting plate 2-16 is installed on the first guide rod 2-14 and the second guide rod 2-17. The liquid supply pump 2-2, the liquid return pump 2-10, the first pressure stabilizing tank 2-3, the second pressure stabilizing tank 2-9, the liquid storage tank 2-13, the first straight pipe joint 2-5, and the second straight pipe joint 2-7 are connected by hoses. The heating device 2-11 is used to heat the coating liquid in the liquid storage tank 2-13, effectively solving the problem that gelatin-based coatings cannot be coated due to cooling and solidification during use.

[0036] Artificial blood vessel coating method: Prepare a polyester woven artificial blood vessel before coating (the initial leakage of the textile-type porous artificial blood vessel is large and it cannot be directly pressurized to 120 mmHg). Connect both ends of the artificial blood vessel to be coated 2-6 to the first direct pipe joint 2-5 and the second direct pipe joint 2-7, and tighten the joints to prevent liquid from leaking out during the coating process, and perform the first coating. Adjust the lifting plate 2-16 to a suitable position to ensure that the artificial blood vessel 2-6 can be completely immersed in the coating liquid to achieve impregnation / perfusion coating under a certain pressure. Turn on the power switch, set the coating pressure value to 60 mmHg, the coating time to 2 min, and the heating temperature of the coating liquid to 37 °C in the control system 1. Press the start button, and the liquid supply pump 2-2 starts to introduce the coating liquid in the liquid storage tank 2-13 into the artificial blood vessel 2-6 to be coated. The liquid return pump 2-10 returns the coating liquid introduced into the artificial blood vessel to the liquid storage tank 2-13. The pressure values monitored by the first pressure sensor 2-4 and the second pressure sensor 2-8 are fed back to the control system 1 to achieve the result of accurately controlling the coating pressure. After the coating is completed, remove the residual solution in the lumen of the artificial blood vessel, and place the artificial blood vessel after the first coating in a blast drying oven and bake it at 40 °C for 2 h. Adjust the rotation direction of the liquid supply pump 2-2 to make the liquid supply pump 2-2 rotate in the reverse direction and the liquid return pump 2-10 rotate in the forward direction, so that the coating liquid in the first pressure stabilizing tank 2-3 and the second pressure stabilizing tank 2-9 is pumped back to the liquid storage tank 2-13 for heating treatment to achieve the reuse of the coating liquid.

[0037] To ensure that the artificial blood vessel has good anti-permeability, perform the second coating. The second coating is to connect both ends of the artificial blood vessel 2-6 to be coated to the first direct pipe joint 2-5 and the second direct pipe joint 2-7, and adjust the height of the lifting plate 2-16 to a position where the artificial blood vessel 2-6 does not touch the coating liquid to achieve perfusion coating under a certain pressure. The coating pressure is set to 120 mmHg, the coating time is 2 min, and the heating temperature of the coating liquid is 37 °C. Start the power supply to start the coating. After the coating is completed, remove the residual solution in the lumen of the artificial blood vessel, and place the artificial blood vessel after the coating in a blast drying oven and bake it at 40 °C for 2 h.

[0038] Water permeability test of the coated artificial blood vessel: Drain the coating liquid in the liquid supply tank 2-13, add secondary distilled water, adjust the lifting plate 2-16 to the highest position, connect both ends of the coated artificial blood vessel 2-6 to the first direct pipe joint 2-5 and the second direct pipe joint 2-7, place a water permeability collection box 2-19 below, weigh the initial weight of the water permeability collection box as 145.62 g, set the pressure value to 120 mmHg, the test time to 10 min, and the heating temperature to 37 °C in the control system, and press the start button to measure the water permeability of the coated artificial blood vessel. After the test is completed, weigh the weight of the water permeability collection box 2-19 as 145.62 g, and the water permeability of the artificial blood vessel after two coatings is 0, indicating that the artificial blood vessel coating has achieved the anti-leakage effect under 120 mmHg. Example

[0039] This embodiment uses the same artificial blood vessel coating device as that in Embodiment 1.

[0040] Artificial blood vessel coating method: Prepare a polyurethane artificial blood vessel before coating (with a small initial leakage volume before coating, which can be pressurized to 120 mmHg). Connect both ends of the artificial blood vessel to be coated 2-6 to the first straight pipe joint 2-5 and the second straight pipe joint 2-7, and tighten the joints to prevent liquid from leaking out during the coating process. Adjust the lifting plate 2-16 to an appropriate position to ensure that the artificial blood vessel 2-6 does not contact the coating liquid, and perform perfusion coating under a certain pressure. Turn on the power switch, set the coating pressure value at 120 mmHg, the coating time at 10 min, and the heating temperature of the coating liquid at 37 °C in the control system 1. Press the start button, and the liquid supply pump 2-2 starts to introduce the coating liquid in the liquid storage tank 2-13 into the artificial blood vessel 2-6 to be coated. The liquid return pump 2-10 returns the coating liquid introduced into the artificial blood vessel to the liquid storage tank 2-13. The monitored pressure values are fed back to the control system 1 through the first pressure sensor 2-4 and the second pressure sensor 2-8 to achieve the result of accurately controlling the coating pressure. After the coating is completed, remove the residual solution in the lumen of the artificial blood vessel, and place the artificial blood vessel after coating in a blast drying oven and bake it at 40 °C for 2 h.

[0041] Water permeability test of the artificial blood vessel after coating: Drain the coating liquid in the liquid supply tank 2-13, add secondary distilled water, adjust the lifting plate 2-16 to the highest position, connect both ends of the artificial blood vessel 2-6 after coating to the first straight pipe joint 2-5 and the second straight pipe joint 2-7, place a water permeability collection box 2-19 below, weigh the initial weight of the water permeability collection box as 145.62 g, set the pressure value at 120 mmHg, the test time at 10 min, and the heating temperature at 37 °C in the control system, and press the start button to measure the water leakage volume of the artificial blood vessel after coating. After the test is completed, weigh the water permeability collection box 2-19, and the weight is 145.62 g. The water leakage volume of the artificial blood vessel after coating twice is 0, indicating that the artificial blood vessel coating has achieved the effect of preventing leakage under 120 mmHg.

[0042] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An artificial blood vessel coating device, characterized in that It includes a control system (1) and a pressurized coating system (2); The control system (1) and the pressurized coating system (2) are electrically connected and used to set and control the coating pressure value, coating time, and the heating temperature of the coating liquid of the pressurized coating system (2); The pressurized coating system includes a base (2-1); A liquid supply pump (2-2), a liquid return pump (2-10), a first pressure stabilizing tank (2-3), a second pressure stabilizing tank (2-9), and a heating device (2-11) are respectively fixed on the base (2-1); A first pressure sensor (2-4) and a second pressure sensor (2-8) are respectively installed on the first pressure stabilizing tank (2-3) and the second pressure stabilizing tank (2-9); A liquid storage tank (2-13) is arranged on the heating device (2-11) to heat the coating liquid inside the liquid storage tank (2-13); A first straight pipe joint (2-5) and a second straight pipe joint (2-7) are arranged inside the liquid storage tank (2-13) to clamp both ends of the artificial blood vessel (2-6); The liquid supply pump (2-2), the first pressure stabilizing tank (2-3), and the first straight pipe joint (2-5) are sequentially connected through a hose; the second straight pipe joint (2-7), the second pressure stabilizing tank (2-9), the liquid return pump (2-10), and the liquid storage tank (2-13) are sequentially connected through a hose; A first guide rod (2-14) and a second guide rod (2-17) are fixedly installed on the base (2-1); A lifting plate (2-16) is installed on the first guide rod (2-14) and the second guide rod (2-17) through a first fixing ring (2-15) and a second fixing ring (2-18). The first fixing ring (2-15) and the second fixing ring (2-18) can move up and down on the first guide rod (2-14) and the second guide rod (2-17) respectively, thereby driving the lifting plate (2-16) to move up and down; The lifting plate (2-16) is of an L-shaped structure with round holes at both ends. The first straight pipe joint (2-5) and the second straight pipe joint (2-7) are installed on the lifting plate (2-16) through the round holes; A liquid discharge port (2-12) is arranged on the liquid storage tank (2-13) for discharging the coating liquid.

2. The artificial blood vessel coating device according to claim 1, characterized in that, The diameters of the first straight pipe joint (2-5) and the second straight pipe joint (2-7) are adjustable, and the adjustable range is 6 mm - 32 mm.

3. An artificial blood vessel coating device according to claim 1, characterized in that, The feed hole of the first pressure stabilizing tank (2-3) and the discharge hole of the second pressure stabilizing tank (2-9) are located at the bottom of the tank body.

4. An artificial blood vessel coating device according to claim 1, characterized in that, The liquid supply pump (2-2) can rotate in both forward and reverse directions. After the artificial blood vessel is removed at the end of the coating, the liquid supply pump rotates in the reverse direction, and the liquid return pump rotates in the forward direction to pump the coating solution inside the first pressure stabilizing tank and the second pressure stabilizing tank back into the liquid storage tank, emptying the coating liquid in the pressure stabilizing tank, and realizing the heating and reuse of the coating liquid.

5. An artificial blood vessel coating device according to claim 1, characterized in that, A PLC controller is arranged inside the control system (1).

6. The artificial blood vessel coating device according to claim 1, wherein, The liquid supply pump and the liquid return pump are screw pumps or gear pumps; the first straight pipe joint (2-5) and the second straight pipe joint (2-7) are ferrule type taper thread straight pipe joints.

7. A method for coating an artificial blood vessel using the artificial blood vessel coating device according to any one of claims 1-6, characterized in that, The steps are as follows: (1) First coating: Prepare a polyester woven artificial blood vessel before coating. Connect both ends of the artificial blood vessel to be coated (2-6) to the first straight pipe joint (2-5) and the second straight pipe joint (2-7), and tighten the joints to prevent liquid from leaking out during the coating process. Then perform the first coating. Adjust the lifting plate (2-16) to an appropriate position to ensure that the artificial blood vessel (2-6) can be completely immersed in the coating liquid, and achieve impregnation / perfusion coating under a certain pressure. Turn on the power switch, set the coating pressure, time, and temperature in the control system (1), and press the start button. The liquid supply pump (2-2) starts to introduce the coating liquid in the liquid storage tank (2-13) into the artificial blood vessel to be coated (2-6), and the liquid return pump (2-10) returns the coating liquid introduced into the artificial blood vessel to the liquid storage tank (2-13). The monitored pressure values are fed back to the control system (1) through the first pressure sensor (2-4) and the second pressure sensor (2-8) to achieve the result of accurately controlling the coating pressure. (2) Drying: After the coating is completed, remove the residual solution in the lumen of the artificial blood vessel. Place the artificial blood vessel after the first coating in a blast drying oven and dry it at 40°C for 2 hours. Adjust the rotation direction of the liquid supply pump (2-2) to make the liquid supply pump (2-2) rotate in the reverse direction and the liquid return pump (2-10) rotate in the forward direction, so that the coating liquid in the first pressure stabilizing tank (2-3) and the second pressure stabilizing tank (2-9) is pumped back to the liquid storage tank (2-13) for heating treatment to achieve the reuse of the coating liquid. (3) Second coating: To ensure that the artificial blood vessel has good anti-permeability, perform the second coating. For the second coating, connect both ends of the artificial blood vessel to be coated (2-6) to the first straight pipe joint (2-5) and the second straight pipe joint (2-7), and adjust the height of the lifting plate (2-16) to a position where the artificial blood vessel (2-6) does not touch the coating liquid, and achieve perfusion coating under a certain pressure. Set the coating pressure, time, and temperature for the coating pressure, start the power supply to start the coating. After the coating is completed, remove the residual solution in the lumen of the artificial blood vessel, and place the artificial blood vessel after the coating in a blast drying oven and dry it at 40°C for 2 hours.

8. A method for coating an artificial blood vessel according to claim 7, characterized in that, The pressure value for the first coating is 60 mmHg, the coating time is 2 minutes, and the heating temperature of the coating liquid is 37°C; the coating pressure for the second coating is set at 120 mmHg, the coating time is 2 - 10 minutes, and the heating temperature of the coating liquid is 37°C.

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