Patch treatment device

Abstract

The present invention provides a plaque treatment device, which includes a catheter, a plaque destruction mechanism and a content recovery mechanism; the plaque destruction mechanism is configured to be switched between an execution state and a first storage state; wherein, the plaque destruction mechanism in the first storage state is loaded on the catheter and is used to move along with the catheter; the plaque destruction mechanism in the execution state is used to destroy the wall of the target plaque, and the content recovery mechanism is used to recover the content of the target plaque. With such a configuration, the plaque destruction mechanism can be used to physically destroy the wall of the target plaque, and then the content of the target plaque can be recovered by the content recovery mechanism and will not cause harm along with blood circulation. It is a mechanical treatment method for vulnerable plaques, and its advantage lies in being able to quickly solve the fundamental problem, achieve precise treatment, and achieve the purpose of quickly and thoroughly treating vulnerable plaques.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a plaque treatment device. Background Art

[0002] Vulnerable plaques, also known as unstable plaques, soft plaques, high-risk plaques, etc., refer to the unstable high-risk plaques in atherosclerotic plaques that are rapid and thrombogenic. The characteristics of such plaques are that the fibrous cap is thin and the lipid core is large, resulting in extremely easy rupture and poor stability, and are prone to acute cardio-cerebrovascular events. For example, in some patients, the stenosis degree is not serious (less than 50%), but due to the vulnerable plaque, acute cardio-cerebrovascular events such as myocardial infarction, cardiac arrest, and acute cerebral infarction may occur at any time. Clinically, it is shown that 75% of acute myocardial infarctions are caused by the rupture of vulnerable plaques, seriously affecting people's living standards.

[0003] The current treatment methods for vulnerable plaques are mainly drug treatments. For example, using statins for intensive lipid-lowering is currently the main treatment method. In addition, there are some other drugs such as anticoagulant and antiplatelet drugs that reduce the local inflammatory reaction of the artery and inhibit thrombus formation after plaque rupture; GPⅡb / Ⅲa antagonists and heparin (UFH) not only improve the perfusion level but also reduce the degree of embolism after use; calcium antagonists can delay the process of coronary atherosclerosis and other drugs can all play a certain role in the treatment of vulnerable plaques. However, these drug treatment methods all have problems such as slow onset, long treatment cycle, and unreliable curative effect. Summary of the Invention

[0004] The purpose of the present invention is to provide a plaque treatment device to solve the problem that the existing vulnerable plaques are mainly treated by drugs.

[0005] To solve the above technical problems, the present invention provides a plaque treatment device, which includes: a catheter, a plaque destruction mechanism, and a content recovery mechanism; the plaque destruction mechanism is configured to convert between an execution state and a first storage state;

[0006] Wherein, the plaque destruction mechanism in the first storage state is loaded on the catheter and is used to move with the catheter; the plaque destruction mechanism in the execution state is used to destroy the wall of the target plaque, and the content recovery mechanism is used to recover the content of the target plaque.

[0007] Optionally, the plaque treatment device further includes a driving mechanism; the driving mechanism is configured to drive the plaque destruction mechanism to switch between the execution state and the first storage state; the plaque destruction mechanism includes a sharp portion connected to the driving mechanism. When the plaque destruction mechanism switches from the first storage state to the execution state, the sharp portion extends radially relative to the catheter and is used to puncture the wall of the target plaque.

[0008] Optionally, the driving mechanism includes a slider and a connecting rod. One end of the connecting rod is connected to the slider, and the other end of the connecting rod is connected to the plaque destruction mechanism; the slider is configured to move along the axial direction of the catheter to drive the plaque destruction mechanism to switch between the execution state and the first storage state through the connecting rod.

[0009] Optionally, the driving mechanism includes a slider accommodating cavity and a driving fluid channel arranged along the axial direction of the catheter. The radial outer contour shape of the slider is adapted to the radial inner contour shape of the slider accommodating cavity, and the slider is axially movably arranged in the slider accommodating cavity; the driving fluid channel is communicated with the slider accommodating cavity, and the driving fluid channel is used to inject driving fluid into the slider accommodating cavity or suck the driving fluid from the slider accommodating cavity to drive the slider to move axially.

[0010] Optionally, the driving mechanism includes a threaded driving member arranged along the axial direction of the catheter. The slider is threadedly connected to the threaded driving member, and the threaded driving member is configured to rotate self to drive the slider to move axially.

[0011] Optionally, the driving mechanism includes two axially spaced sliders and at least two connecting rods; each slider is connected to at least one connecting rod; the two sliders are configured to move synchronously in opposite directions.

[0012] Optionally, the plaque destruction mechanism includes an expansion matrix arranged outside the catheter. The expansion matrix extends along the axial direction of the catheter. The sharp portion is arranged on the expansion matrix. The expansion matrix is connected to the other end of the connecting rod, and the expansion matrix is configured to move radially under the drive of the connecting rod; wherein, when the plaque destruction mechanism is in the first storage state, the expansion matrix abuts against the outer wall of the catheter; when the plaque destruction mechanism is in the execution state, the expansion matrix moves radially away from the catheter and is used to squeeze the wall of the target plaque.

[0013] Optionally, the plaque treatment device further includes a driving mechanism; the driving mechanism is used to drive the plaque destruction mechanism to switch between the execution state and the first storage state; the driving mechanism includes a driving wire and a guiding member, the driving wire is connected to the sharp portion; the guiding member is used to guide and change the extending direction of the driving wire; wherein, when the plaque destruction mechanism is in the first storage state, the sharp portion does not protrude beyond the guiding member and the more outward one of the catheters; when the plaque destruction mechanism switches from the first storage state to the execution state, the sharp portion extends out of the guiding member and the catheter in a direction angled with the axial direction of the catheter under the drive of the driving wire, for puncturing the wall of the target plaque.

[0014] Optionally, the guiding member includes a guiding tube section with an arc-shaped extension, the proximal tangential direction of the guiding tube section extends along the axial direction of the catheter, and the distal tangential direction of the guiding tube section extends at an angle with the axial direction of the catheter and penetrates the outer wall of the catheter; the guiding tube section is used for the driving wire to pass through movably, and is used to guide and change the extending direction of the driving wire.

[0015] Optionally, the content recovery mechanism includes a blocking member, the blocking member has selective permeability, and it allows the passage of sizes not larger than part of the content; the blocking member is configured to switch between a blocking state and a second storage state;

[0016] When the blocking member is in the blocking state, it is used to block the downstream side of the target plaque to collect the content with a size larger than the allowable passage size;

[0017] When the blocking member is in the second storage state, it is loaded on the catheter and is used to move with the catheter;

[0018] Wherein, during the process of the blocking member switching from the blocking state to the second storage state, it prevents the collected content from detaching from the blocking member.

[0019] Optionally, the plaque destruction mechanism includes a sharp portion, the content recovery mechanism includes a recovery hole axially penetrating through the sharp portion along the axial direction of the sharp portion, and further includes a recovery channel extending along the axial direction of the catheter, the recovery hole is communicated with the recovery channel; the recovery channel and the recovery hole are used for sucking out the content of the target plaque.

[0020] Optionally, the content recovery mechanism further includes a plurality of side branch holes, the side branch holes are radially opened on the side wall of the sharp portion along the radial direction of the sharp portion and are communicated with the recovery hole; the side branch holes allow the content of the target plaque to pass through.

[0021] Optionally, the catheter is a multi-lumen tube.

[0022] In summary, the plaque treatment device provided by the present invention includes a catheter, a plaque destruction mechanism, and a content recovery mechanism; the plaque destruction mechanism is configured to switch between an execution state and a first storage state; wherein, the plaque destruction mechanism in the first storage state is loaded on the catheter and is used to move along with the catheter; the plaque destruction mechanism in the execution state is used to destroy the wall of the target plaque, and the content recovery mechanism is used to recover the content of the target plaque.

[0023] With such a configuration, the plaque destruction mechanism can be used to physically destroy the wall of the target plaque, and then the content of the target plaque can be recovered by the content recovery mechanism and will not cause harm through blood circulation. It is a mechanical treatment method for vulnerable plaques, and its advantage lies in being able to quickly solve the fundamental problem, achieve precise treatment, and achieve the purpose of quickly and thoroughly treating vulnerable plaques. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Those of ordinary skill in the art will understand that the provided drawings are used to better understand the present invention and do not constitute any limitation to the scope of the present invention. Among them:

[0025] Figure 1 is a schematic diagram of the plaque treatment device according to an embodiment of the present invention;

[0026] Figure 2 is a schematic diagram of a preferred example of the plaque destruction mechanism and the content recovery mechanism according to an embodiment of the present invention;

[0027] Figure 3 is Figure 2 a partial enlarged view of the plaque destruction mechanism shown;

[0028] Figure 4 is a schematic diagram of the cross-section of the catheter according to an embodiment of the present invention;

[0029] Figure 5 is a schematic diagram of a preferred example of the driving mechanism according to an embodiment of the present invention;

[0030] Figure 6 is a schematic diagram of another preferred example of the driving mechanism according to an embodiment of the present invention;

[0031] Figure 7 is a schematic diagram of a preferred example of the sharp part according to an embodiment of the present invention;

[0032] Figure 8 is Figure 3 a schematic diagram of the sharp part piercing the target plaque;

[0033] Figure 9It is a schematic diagram of another preferred example of the plaque destruction mechanism and the content recovery mechanism of the embodiments of the present invention;

[0034] Figure 10 is Figure 9 a schematic diagram of the sharp part piercing the target plaque.

[0035] In the drawings:

[0036] 1 - catheter; 2 - plaque destruction mechanism; 21 - sharp part; 22 - expansion matrix; 3 - content recovery mechanism; 31 - recovery hole; 32 - recovery channel; 33 - branch hole; 34 - plug; 4 - target plaque; 41 - wall; 42 - blood vessel; 5 - driving mechanism; 51 - slider; 52 - connecting rod; 53 - slider accommodation cavity; 54 - driving fluid channel; 55 - block; 56 - threaded driving part; 57 - guiding part; 571 - extending pipe section; 572 - guiding pipe section. Detailed implementation manners

[0037] To make the objectives, advantages and features of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be noted that the accompanying drawings are in very simplified forms and are not drawn to scale, and are only used to facilitate and clearly assist in explaining the objectives of the embodiments of the present invention. In addition, the structures shown in the accompanying drawings are often part of the actual structures. In particular, the accompanying drawings need to show different emphases and sometimes different scales are used.

[0038] As used in the present invention, the singular forms "a", "an" and "the" include plural referents, the term "or" is generally used in the sense of including "and / or", the term "several" is generally used in the sense of including "at least one", the term "at least two" is generally used in the sense of including "two or more", in addition, the terms "first", "second", "third" are only used for descriptive purposes and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first", "second", "third" may explicitly or implicitly include one or at least two of such features, "one end" and "the other end" and "proximal end" and "distal end" generally refer to corresponding two parts, which include not only the endpoints. The terms "proximal end" and "distal end" are defined herein relative to a plaque treatment device having one end for intervening in the human body and a control end extending out of the body. The term "proximal end" refers to the position of an element closer to the control end of the plaque treatment device extending out of the body, and the term "distal end" refers to the position of an element closer to the end of the plaque treatment device intervening in the human body and thus farther from the control end of the plaque treatment device. Optionally, in an application scenario of manual or hand operation, the terms "proximal end" and "distal end" are defined herein relative to an operator such as a surgeon or a clinician. The term "proximal end" refers to the position of an element closer to the operator, and the term "distal end" refers to the position of an element closer to the plaque treatment device and thus farther from the operator. In addition, as used in the present invention, "mounted", "connected", "coupled", an element "disposed" on another element should be understood in a broad sense, generally only indicating that there is a connection, coupling, cooperation or transmission relationship between the two elements, and the two elements can be directly or indirectly connected, coupled, cooperated or transmitted through an intermediate element, and should not be construed as indicating or implying the spatial position relationship between the two elements, that is, an element can be in any position such as inside, outside, above, below or on one side of another element, unless the content clearly indicates otherwise. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. In addition, directional terms such as above, below, up, down, upward, downward, left, right are used relative to an exemplary embodiment as shown in the figures, the upward or upper direction is towards the top of the corresponding figure, and the downward or lower direction is towards the bottom of the corresponding figure.

[0039] The object of the present invention is to provide a plaque treatment device to solve the problem that existing vulnerable plaques are mainly treated by drugs.

[0040] The following is described with reference to the accompanying drawings.

[0041] Please refer to Figures 1 to 8, an embodiment of the present invention provides a plaque treatment device, which includes: a catheter 1, a plaque destruction mechanism 2 and a content recovery mechanism 3; the plaque destruction mechanism 2 is configured to switch between an execution state and a first storage state; wherein, the plaque destruction mechanism 2 in the first storage state is loaded on the catheter 1 and is used to move along with the catheter 1; the plaque destruction mechanism 2 in the execution state is used to destroy the wall 41 of the target plaque 4, and the content recovery mechanism 3 is used to recover the content of the target plaque 41. It should be noted that the target plaque 4 can be, for example, a vulnerable plaque on a patient's blood vessel, or a plaque prosthesis on a blood vessel model, which can be used by an operator for training or surgical verification, etc. The present invention does not limit the specific content of the target plaque 4.

[0042] Please refer to Figure 2 and Figure 3 , taking a target plaque 4 formed on the side wall of a blood vessel 42 as an example for illustration, some substantially solid contents (such as a lipid core) and some liquids are accommodated inside the target plaque 4, and the inner side of the target plaque 4 facing the blood vessel 42 is its wall 41. It can be understood that after the wall 41 of the target plaque 4 is destroyed by the plaque destruction mechanism 2, the content in the target plaque 4 will flow into the blood vessel 42. When the content flows with the blood to a narrow area, it will cause blockage, thereby triggering acute cardiovascular and cerebrovascular events. The setting of the content recovery mechanism 3 can recover the content flowing out of the target plaque 41. With such a configuration, the plaque destruction mechanism 3 can be used to physically destroy the wall 41 of the target plaque 4, and then the content of the target plaque 4 can be recovered by the content recovery mechanism 3 and will not cause harm along with the blood circulation. It is a mechanical treatment method for vulnerable plaques, and its advantage is that it can quickly solve the fundamental problem, achieve precise treatment, and achieve the purpose of quickly and thoroughly treating vulnerable plaques.

[0043] Furthermore, the plaque destruction mechanism 2 has an execution state and a first storage state, and is configured to be able to switch between the execution state and the first storage state. The main application scenario of the plaque treatment device provided in this embodiment is to intervene from a blood vessel 42 (or a blood vessel model) and move forward along the blood vessel to the target plaque 4. During the intervention process, the plaque destruction mechanism 2 is mainly in the first storage state, and it can move smoothly along with the catheter 1 along the blood vessel 42, and minimize or avoid harm to the blood vessel wall during the movement. It should be noted that there are various implementation methods for the plaque destruction mechanism 2 to be loaded on the catheter 1 when it is in the first storage state. For example Figure 1 and Figure 2 In the exemplary examples shown, the plaque destruction mechanism 2 is radially telescopically arranged outside the catheter 1. At this time, the way the plaque destruction mechanism 2 is loaded on the catheter 1 can be to radially contract until it abuts against the outer peripheral wall of the catheter 1. In some other embodiments, for exampleFigure 9 In the illustrated exemplary embodiment, the plaque disruption mechanism 2 can be loaded inside the catheter 1 in a contracted state. Based on the above description, the present invention does not particularly limit the way the plaque disruption mechanism 2 is loaded into the catheter 1. However, it should be ensured that when the plaque disruption mechanism 2 is loaded into the catheter 1, it does not affect the advancement and retraction of the catheter 1 along the blood vessel 42. When in the execution state, the plaque disruption mechanism 2 can extend outside the catheter 1, so as to be used to puncture the wall 41 of the target plaque 4. In some embodiments, if the target plaque 4 is located on the side wall of a substantially straight section of the blood vessel 42, then when in the execution state, the plaque disruption mechanism 2 can extend radially relative to the catheter 1. In some other embodiments, when the target plaque 4 is located at a bend of the blood vessel 42, the execution state of the plaque disruption mechanism 2 can also be that the plaque disruption mechanism 2 extends axially relative to the catheter 1, which can be understood and improved by those skilled in the art according to the prior art.

[0044] Preferably, the plaque treatment device further includes a driving mechanism 5; the driving mechanism 5 is used to drive the plaque disruption mechanism 2 to switch between the execution state and the first storage state; the plaque disruption mechanism 2 includes a sharp part 21 connected to the driving mechanism 5. When the plaque disruption mechanism 2 switches from the first storage state to the execution state, the sharp part 21 extends radially relative to the catheter 1 to puncture the wall 41 of the target plaque 4. In some embodiments, the switching of the plaque disruption mechanism 2 between the execution state and the first storage state can be achieved spontaneously without driving. For example, if the plaque disruption mechanism 2 includes a self-expanding mesh stent, when the mesh stent extends from the distal end of the catheter 1, it can expand spontaneously to achieve the transition from the first storage state to the execution state. However, preferably, by additionally providing a driving mechanism 5 to drive the plaque disruption mechanism 2 to switch between the execution state and the first storage state, the state transition of the plaque disruption mechanism 2 can be reliably achieved, and the action accuracy of the plaque disruption mechanism 2 can be improved.

[0045] As Figure 2 shown, optionally, the driving mechanism 5 includes a slider 51 and a connecting rod 52. One end of the connecting rod 52 is connected to the slider 51, and the other end of the connecting rod 52 is connected to the plaque disruption mechanism 2; the slider 51 is used to move axially along the catheter 1 to drive the plaque disruption mechanism 2 to switch between the execution state and the first storage state through the connecting rod 52.

[0046] In a preferred example, the movement of the slider 51 can be achieved by injecting or sucking a driving fluid (liquid or gas). Optionally, the driving mechanism 5 includes a slider accommodation cavity 53 and a driving fluid channel 54 arranged along the axial direction of the catheter 1. The radial outer contour shape of the slider 51 is adapted to the radial inner contour shape of the slider accommodation cavity 53. The slider 51 is axially movably arranged in the slider accommodation cavity 53. The driving fluid channel 54 communicates with the slider accommodation cavity 53 and is used for injecting the driving fluid into the slider accommodation cavity 53 or sucking the driving fluid from the slider accommodation cavity 53 to drive the slider 51 to move axially.

[0047] Please refer to Figure 4 and Figure 5 , optionally, the catheter 1 is a multi-chamber tube having a plurality of channels in the radial direction, and the slider accommodation cavity 53 is one of the channels. In one embodiment, a blocking block 55 is provided at the proximal end of the slider accommodation cavity 53, and the slider 51 is movably arranged at the distal end of the slider accommodation cavity 53. Preferably, both the radial outer contour shape of the slider 51 and the radial inner contour shape of the slider accommodation cavity 53 are circular. The outer diameter of the slider 51 matches the inner diameter of the slider accommodation cavity 53. The slider 51 can be in airtight contact with the slider accommodation cavity 53 while sliding, thereby defining the volume of the slider accommodation cavity 53. With such a configuration, when the driving fluid is injected into the slider accommodation cavity 53 through the driving fluid channel 54, the slider 51 will be pushed in the distal direction ( Figure 5 the right direction in Figure 5 ). Conversely, when the driving fluid is sucked from the slider accommodation cavity 53 through the driving fluid channel 54, the slider 51 will be pushed in the proximal direction ( Figure 5 the left direction in

[0048] ). Optionally, the driving fluid channel 54 can also be opened in the catheter 1 and is one of the channels of the catheter 1. Preferably, the slider accommodation cavity 53 and the driving fluid channel 54 are the same channel, and the two are separated by the blocking block 55. At the same time, the blocking block 55 has an axially penetrating through-hole, and the slider accommodation cavity 53 communicates with the driving fluid channel 54 through the through-hole opened on the blocking block 55. The proximal end of the driving fluid channel 54 extends out of the body along the catheter 1, and the operator can inject or suck the driving fluid through the proximal end of the driving fluid channel 54. Such a configuration is beneficial to reducing the radial size of the catheter 1 and improving the passing performance. Of course, in some other embodiments, the driving fluid channel 54 can also be another channel of the catheter 1 different from the slider accommodation cavity 53, or an attached channel attached to the outside of the catheter 1. The present invention is not limited thereto.Further, in one embodiment, the plaque disruption mechanism 2 includes an expansion matrix 22 disposed outside the catheter 1. The expansion matrix 22 extends along the axial direction of the catheter 1. The sharp portion 21 is disposed on the expansion matrix 22. The expansion matrix 22 is connected to the other end of the connecting rod 52. The expansion matrix 22 is configured to move radially under the drive of the connecting rod 52. When the plaque disruption mechanism 2 is in the first storage state, the expansion matrix 22 abuts against the outer wall of the catheter 1. When the plaque disruption mechanism 22 is in the execution state, the expansion matrix 22 moves radially away from the catheter 1 and is configured to squeeze the wall 41 of the target plaque 4. Optionally, both ends of the connecting rod 52 are hinged to the expansion matrix 22 and the slider 51 respectively. Optionally, one end of the connecting rod 52 connected to the slider 5 is located inside the catheter 1, and the end connected to the expansion matrix 22 is located outside the catheter 1. Therefore, the connecting rod 52 needs to pass through the catheter 1. For this purpose, a through slot can be opened in the catheter 1 corresponding to the position of the connecting rod 52 to facilitate the passing of the connecting rod 52. In this way, the axial sliding of the slider 51 is converted into the radial movement of the expansion matrix 22, thereby driving the sharp portion 21 to move radially and piercing the wall 41.

[0049] Preferably, the plaque disruption mechanism 2 includes at least two expansion matrices 22. The at least two expansion matrices 22 are circumferentially and uniformly distributed around the axis of the slider accommodation cavity 53. Each expansion matrix 22 is connected to the slider 51 through a corresponding connecting rod 52. With such a configuration, when the slider 51 moves axially, the at least two expansion matrices 22 can be uniformly expanded in different directions. It should be noted that when the plaque disruption mechanism 2 includes at least two expansion matrices 22, only one expansion matrix 22 is provided with the sharp portion 21, and the other expansion matrices 22 are only used for expansion and abut against the inner wall of the blood vessel 42, providing a reaction force for the expansion matrix 22 provided with the sharp portion 21, so that the expansion matrix 22 provided with the sharp portion 21 can squeeze the target plaque 4 and squeeze out the content of the target plaque 4 as much as possible. Figure 5 In the illustrated exemplary embodiment, the plaque disruption mechanism 2 includes two expansion matrices 22, which are symmetrically distributed about the axis of the slider accommodation cavity 53. In some other embodiments, the expansion matrix 22 can also be an annular grid body, which is connected to the slider 51 through multiple connecting rods 52. In this way, when the slider 51 moves axially, it can drive the expansion matrix 22 to expand or contract radially and uniformly. Optionally, the expansion matrix 22 can be, for example, an expansion arm or an expansion plate. Parameters such as its quantity, size, cross-sectional shape, circumferential extension area, and distribution depend on the engineering implementation and the extrusion area of the target plaque 4. The expansion matrix 22 is preferably made of biocompatible materials such as stainless steel, titanium alloy, and organic polymers, and it should have a certain strength to achieve the extrusion of the target plaque 4.

[0050] Please continue to refer to Figure 3, in another alternative embodiment, the driving mechanism 5 includes two sliders 51 arranged at intervals along the axial direction and at least two connecting rods 52; each slider 51 is connected to at least one connecting rod 52; the two sliders 51 are configured to move synchronously in opposite directions. The proximal end of the slider accommodation cavity 53 also uses another slider 51 to replace the fixedly arranged blocking block 55, so that the space enclosed between the two sliders 51 defines the slider accommodation cavity 53. Thus, when driving fluid is injected into or sucked from the slider accommodation cavity 53 through the driving fluid channel 54, the two sliders 51 will move synchronously in opposite directions. Further, the two sliders 51 are connected to the expansion base 22 through their respective corresponding connecting rods 52, so that the two sliders 51 moving synchronously in opposite directions can simultaneously drive the two axial ends of the expansion base 22 to move radially together, so that the expansion base 22 can move more smoothly radially, for example, move radially perpendicular to the axial direction of the slider accommodation cavity 53. Optionally, the slider 51 located at the proximal end has an axially penetrating through hole, and the slider accommodation cavity 53 communicates with the driving fluid channel 54 through the through hole opened on the slider 51.

[0051] Please refer to Figure 6 , in another preferred example, the movement of the slider 51 can be achieved by screw mechanical drive. Optionally, the driving mechanism 5 includes a screw driving member 56 arranged along the axial direction of the catheter 1, the slider 51 is threadedly connected to the screw driving member 56, and the screw driving member 56 is used for self-rotation to drive the slider 51 to move axially. In one embodiment, the screw driving member 56 is a lead screw with an external thread, and the slider 51 has an internal thread adapted to the external thread of the lead screw, so that when the screw driving member 56 rotates, the slider 51 can be driven to move axially. In another embodiment, the screw driving member 56 can also be a sleeve with an internal thread, and the slider 51 has an external thread matching the internal thread of the sleeve, so that the slider 51 can also be driven to move axially by the rotation of the screw driving member 56. Further, the driving mechanism 5 can also include two sliders 51 arranged at intervals along the axial direction, the two sliders 51 are simultaneously threadedly connected to the screw driving member 56, and the threads of the two sliders 51 have opposite helix directions. Correspondingly, the screw driving member 56 has two threads with opposite helix directions to match the threads of the two sliders 51. With such a configuration, when the screw driving member 56 rotates, it can synchronously drive the two sliders 51 to move synchronously in opposite directions.

[0052] Optionally, please refer to Figure 3, in a preferred example, the content recovery mechanism 3 includes a recovery hole 31 axially penetrating through the sharp part 21 on the sharp part 21. The content recovery mechanism 3 further includes a recovery channel 32 extending along the axis of the catheter 1. The recovery hole 31 communicates with the recovery channel 32; the recovery channel 32 and the recovery hole 31 are used for sucking out the content of the target plaque 4. In this preferred example, the sharp part 21 is generally a hollow needle body, one end of which is sharp and can pierce the wall 41 of the target plaque 4 and enter the inside of the target plaque 4. Preferably, the extended base 22 provided with the sharp part 21 is a hollow part with an inner cavity. The distal end of the inner cavity is closed, and the proximal end of the inner cavity is connected to a channel of the catheter 1 through a connecting tube. The recovery hole 31 communicates with the inner cavity of the extended base 22. In this way, the inner cavity of the extended base 22, the connecting tube and the channel of the catheter 1 connected in sequence from the distal end to the proximal end together constitute the recovery channel 32. The proximal end of the recovery channel 32 extends out of the body. The operator can recover the content contained inside the target plaque 4 through the recovery channel 32 and the recovery hole 31. For example, it can be aspirated, or the content can be extruded by squeezing the target plaque 4 through the extended base 22. It can be understood that the inner diameters of the recovery channel 32 and the recovery hole 31 should be larger than the size of the content so that the content can be smoothly discharged.

[0053] Please refer to Figure 7 and Figure 8 , further, the content recovery mechanism 3 further includes a plurality of branch holes 33. The branch holes 32 are radially opened on the side wall of the sharp part 21 along the radial direction of the sharp part 21 and communicate with the recovery hole 31; the branch holes 33 allow the content of the target plaque 4 to pass through. With reference to Figure 3, examine the entire recycling process of the contents of the target plaque 4 by the content recycling mechanism 3. The sharp part 21 first pierces the package wall 41 and enters the target plaque 4. At this stage, the contents of the target plaque 4 can enter the recycling channel 32 through the recycling hole 31 of the sharp part 21. Then, the expanding matrix 22 moves outward and abuts against the package wall 41, exerting pressure on the target plaque 4. At this stage, the contents of the target plaque 4 can still enter the recycling channel 32 through the recycling hole 31 of the sharp part 21. Further, in order to enable the contents of the target plaque 4 to be discharged as completely as possible, the expanding matrix 22 continues to move outward and squeeze the target plaque 4. At this stage, the tip of the sharp part 21 may have pierced through the entire target plaque 4 and penetrated into the blood vessel wall, or even pierced through the blood vessel wall and reached the extravascular tissue. At this stage, the distal end of the recycling hole 31 has extended beyond the target plaque 4 and cannot allow the contents to pass through. The setting of the side branch hole 33 provides another way for the contents to enter the recycling hole 31. When the expanding matrix 22 continues to squeeze the target plaque 4, the contents of the target plaque 4 can enter the recycling hole 31 through the side branch hole 33. It can be understood that since the side branch hole 33 allows the contents to pass through, its inner diameter should be larger than the size of the contents.

[0054] Further, in order to avoid excessive damage to the blood vessel 42, the outer diameter of the sharp part 21 should be set as small as possible. For example, the inner diameter of the recycling hole 31 is slightly larger than the possible maximum size of the contents. To accelerate the discharge speed of the contents, the plaque destruction mechanism 2 includes more than two sharp parts 21. Increasing the number of sharp parts 21 can reduce the negative impact of the size of the sharp part 21 on the effectiveness. In one embodiment, more than two sharp parts 21 are all arranged on the same expanding matrix 22.

[0055] Please refer to Figure 9 and Figure 10, in another preferred example, the driving mechanism 5 includes a driving wire (not shown) and a guiding member 57, the driving wire is connected to the sharp portion 21; the guiding member 57 is used to guide and change the extending direction of the driving wire, so as to allow the driving wire to drive the plaque destruction mechanism 2 to switch between the execution state and the first storage state; wherein, when the plaque destruction mechanism 2 is in the first storage state, the sharp portion 21 does not protrude beyond the guiding member 57 and the more outward one of the catheter 1; when the plaque destruction mechanism 2 switches from the first storage state to the execution state, the sharp portion 21 extends out of the guiding member 57 and the catheter 1 along a direction angled with the axial direction of the catheter 1 under the drive of the driving wire, for puncturing the wall 41 of the target plaque 4. Specifically, in some embodiments, the guiding member 57 may be entirely located within the catheter 1, that is to say, among the guiding member 57 and the catheter 1, the catheter 1 is the more outward one. At this time, when the plaque destruction mechanism 2 is in the first storage state, it means that the sharp portion 21 does not protrude out of the catheter 1. At this time, even if the sharp portion 21 protrudes out of the guiding member 57, as long as it does not exceed the outer wall of the catheter 1, it can be shielded and protected by the catheter 1. In other embodiments, a part of the guiding member 57 may protrude out of the catheter 1, that is to say, among the guiding member 57 and the catheter 1, the guiding member 57 is the more outward one. At this time, even if the sharp portion 21 protrudes out of the outer wall of the catheter 1, it doesn't matter as long as it does not protrude out of the guiding member 57.

[0056] As Figure 9 shown, in a demonstration example, the guiding member 57 is a tubular member, which includes an extending pipe section 571 located within the catheter 1, and the extending pipe section 571 can be, for example, a cavity of the catheter 1. Further, the guiding member 57 further includes a guiding pipe section 572 extending in an arc shape. The proximal end of the guiding pipe section 572 extends tangentially along the axial direction of the catheter 1, for example, connected to the extending pipe section 571. The distal end of the guiding pipe section 572 extends tangentially at an angle with the axial direction of the catheter 1 and penetrates the outer wall of the catheter 1. The guiding pipe section 572 is used for the driving wire to pass through movably, and is used to guide and change the extending direction of the driving wire. Optionally, the proximal end of the driving wire passes through the extending pipe section 571 and extends out of the body, and the operator can operate the driving wire to move forward and backward. It can be understood that the driving wire passes through the guiding member 57 movably, and its advancing and retreating directions will be restricted and guided by the guiding member 57. When the driving wire and the sharp portion 21 provided at its distal end move distally to the guiding pipe section 572, they gradually turn outward. Then, after passing through the guiding pipe section 572, the extending direction of the driving wire and the sharp portion 21 forms an angle with the axial direction of the catheter 1, until it extends out of the catheter 1. Further pushing the driving wire distally, so that the sharp portion 21 extends out of the guiding pipe section 572, and the plaque destruction mechanism 2 switches to the execution state. It can be understood that when the sharp portion 21 does not extend out of the guiding pipe section 572, the plaque destruction mechanism 2 can be considered to be in the first storage state.

[0057] Adapted to Figure 9 and Figure 10 In the plaque disruption mechanism 2 in the illustrated exemplary example, the content recovery mechanism 3 may also be the same as the foregoing exemplary example, that is, it includes a recovery hole 31 and a recovery channel 32. After the sharp part 21 pierces the wall 41 of the target plaque 4 and enters the interior of the target plaque 4, the content of the target plaque 4 can be aspirated by sucking at the proximal end of the recovery channel 32.

[0058] Furthermore, this embodiment also provides another preferred example of the content recovery mechanism 3. The content recovery mechanism 3 includes a blocking member 34. The blocking member 34 has selective permeability, and it allows the passage of substances with a size not greater than that of part of the content; the blocking member 34 is configured to be convertible between a blocking state and a second storage state; when the blocking member 34 is in the blocking state, it is used to block the downstream side of the target plaque 4 to collect the content with a size greater than the allowable passage size; when the blocking member 34 is in the second storage state, it is loaded on the catheter 1 and is used to move with the catheter 1; wherein, during the process of the blocking member 34 transitioning from the blocking state to the second storage state, it prevents the collected content from detaching from the blocking member 34.

[0059] Optionally, the blocking member 34 includes an expandable and contractible elastic structure. This elastic structure is, for example, a mesh support made of nitinol wire. Thus, the blocking member 34 can contract and be received into the catheter 1 to be transported into the blood vessel 42 along with the catheter 1. When reaching near the target plaque 4, the blocking member 34 is driven to extend out of the distal end of the catheter 1, and then the blocking member 34 expands and blocks downstream of the target plaque 4. It should be noted that here, the downstream refers to the downstream side along the blood flow direction in the blood vessel 42. For example Figure 9 In the illustrated exemplary example, the blood flow direction is from left to right, then the blocking member 34 is located on the right side of the target plaque 4. Since the elastic structure of the blocking member 34, such as the mesh support, has relatively large voids, furthermore, the blocking member 34 further includes a semi-permeable membrane, and the semi-permeable membrane covers the elastic structure. Preferably, when the blocking member 34 expands and blocks downstream of the target plaque 4, the semi-permeable membrane and the elastic structure can completely cover the entire cross-section of the blood vessel 42. The semi-permeable membrane has selective permeability, and it allows the passage of substances with a size not greater than that of part of the content. And, the allowable passage size is greater than the size of blood cells and other blood substances. In this way, the semi-permeable membrane can allow blood cells and other blood substances to pass through. When the blocking member 34 expands and blocks in the blood vessel 42, the content in the target plaque 4 with a relatively large size that can form a thrombus risk can be blocked by the semi-permeable membrane on the side where the blood flows in, avoiding risks caused by blood circulation.

[0060] Furthermore, during the process of the blocking member 34 transitioning from the blocking state to the second storage state, it can prevent the collected contents from detaching from the blocking member 34. In a demonstration example, the elastic structure of the blocking member 34 is, for example, umbrella-shaped, and during the process of moving towards the proximal end and being received into the catheter 1, it will not cause the contents to detach.

[0061] Preferably, in Figure 9 and Figure 10 In the demonstration example shown, the sharp portion 21 can be blade-shaped, which can not only pierce the target plaque 4, but also be used to cut open the wall 42 of the package, so that the contents in the target plaque 4 can quickly flow out into the blood vessel 42.

[0062] In use, the catheter 1 is transported along the guide wire to near the target plaque 4. The catheter 1 can rotate circumferentially, and the distal end of the guiding tube section 572 is tangentially facing the target plaque 4. At this time, the driving blocking member 34 is released at a position downstream of the target plaque 4 and transitions to the blocking state to block in the blood vessel 42. Then, the driving wire and the sharp portion 21 are pushed, so that the driving wire and the sharp portion 21 move forward and extend out of the catheter 1 under the guidance of the guiding tube section 572 until the sharp portion 21 is facing the target plaque 4. At this time, the sharp portion 21 is operated to cut through the wall 41 of the target plaque 4 and release the contents in the target plaque 4. The contents reach near the blocking member 34 under the action of blood flow and are blocked by the semipermeable membrane under the action of blood pressure and collected by the blocking member 34. Until the contents in the target plaque 4 are basically filtered and adsorbed on the surface of the semipermeable membrane of the blocking member 34, the blocking member 34 can be recovered, so that the blocking member 34 transitions to the second storage state, and the blocking member 34 together with the filtered and collected contents is loaded into the catheter 1 and withdrawn from the body.

[0063] It can be understood that the preferred example of the content recovery mechanism 3 including the blocking member 34 is not limited to being applied in the demonstration examples shown in Figure 9 and Figure 10 It can also be applied in the preferred example shown in Figure 2 In addition, the content recovery mechanism 3 is not limited to only including one of the blocking member 34 or the recovery hole 31, and it can also be the combination of both. For example, in the demonstration example shown in Figure 2 It can also combine the solution of the blocking member 34. In this way, once a small amount of content leaks out from the wall 41 when being squeezed, it can also be recovered by the blocking member 34, improving the reliability and safety.

[0064] In summary, the plaque treatment device provided by the present invention includes a catheter, a plaque destruction mechanism, and a content recovery mechanism; the plaque destruction mechanism is configured to be convertible between an execution state and a first storage state; wherein, the plaque destruction mechanism in the first storage state is loaded on the catheter and is used to move with the catheter; the plaque destruction mechanism in the execution state is used to destroy the wall of the target plaque, and the content recovery mechanism is used to recover the content of the target plaque. With such a configuration, the plaque destruction mechanism can be used to physically destroy the wall of the target plaque, and then the content of the target plaque can be recovered by the content recovery mechanism and will not cause harm along with blood circulation. It is a mechanical treatment method for vulnerable plaques, and its advantage lies in being able to quickly solve the root problem, achieve precise treatment, and achieve the purpose of quickly and thoroughly treating vulnerable plaques.

[0065] It should be noted that the above-mentioned several embodiments can be combined with each other. The above description is only a description of the preferred embodiments of the present invention and does not limit the scope of the present invention in any way. Any changes and modifications made by those of ordinary skill in the field of the present invention according to the above disclosure are within the protection scope of the claims.

Claims

1. A plaque treatment device, characterized in that, Comprising: A catheter, a plaque disruption mechanism, a content recovery mechanism, and a drive mechanism; the plaque disruption mechanism is configured to switch between an execution state and a first storage state; Wherein, the plaque disruption mechanism in the first storage state is loaded on the catheter and is used to move along with the catheter; the plaque disruption mechanism in the execution state is used to disrupt the wall of the target plaque, and the content recovery mechanism is used to recover the content of the target plaque; The plaque disruption mechanism includes a sharp part connected to the drive mechanism. When the plaque disruption mechanism switches from the first storage state to the execution state, the sharp part extends radially relative to the catheter and is used to pierce the wall of the target plaque; The drive mechanism includes a slider and a connecting rod. One end of the connecting rod is connected to the slider, and the other end of the connecting rod is connected to the plaque disruption mechanism; the slider is used to move along the axial direction of the catheter to drive the plaque disruption mechanism to switch between the execution state and the first storage state through the connecting rod; the plaque disruption mechanism includes an expansion base body arranged outside the catheter, the sharp part is arranged on the expansion base body, and the expansion base body is connected to the other end of the connecting rod. The expansion base body is used to move radially under the drive of the connecting rod.

2. The plaque treatment device according to claim 1, wherein The drive mechanism includes a slider accommodation cavity and a drive fluid channel arranged along the axial direction of the catheter. The radial outer contour shape of the slider is adapted to the radial inner contour shape of the slider accommodation cavity. The slider is axially movably arranged in the slider accommodation cavity; the drive fluid channel is communicated with the slider accommodation cavity, and the drive fluid channel is used to supply drive fluid into the slider accommodation cavity or suck the drive fluid from the slider accommodation cavity to drive the slider to move axially.

3. The plaque treatment device according to claim 1, characterized in that, The drive mechanism includes a threaded drive member arranged along the axial direction of the catheter. The slider is threadedly connected to the threaded drive member, and the threaded drive member is used to rotate self to drive the slider to move axially.

4. The plaque treatment device according to any one of claims 1 to 3, characterized in that, The drive mechanism includes two axially spaced sliders and at least two connecting rods; each slider is connected to at least one connecting rod; the two sliders are configured to move synchronously in opposite directions.

5. The plaque treatment device according to claim 1, characterized in that, The expansion base body extends along the axial direction of the catheter. Wherein, when the plaque disruption mechanism is in the first storage state, the expansion base body abuts against the outer wall of the catheter; when the plaque disruption mechanism is in the execution state, the expansion base body moves radially away from the catheter and is used to squeeze the wall of the target plaque.

6. The plaque treatment device according to claim 1, characterized in that, The content recovery mechanism includes a blocking member. The blocking member has selective permeability, and it allows the passage of substances with a size not greater than part of the content; the blocking member is configured to switch between a blocking state and a second storage state; When the blocking member is in the blocking state, it is used to block the downstream side of the target plaque to collect the content with a size greater than the allowable passage size; When the blocking member is in the second storage state, it is loaded on the catheter and is used to move along with the catheter; During the process of the plugging member transitioning from the plugged state to the second storage state, the collected content is prevented from detaching from the plugging member.

7. The plaque treatment device according to claim 1, wherein, The plaque disruption mechanism includes a sharp portion. The content recovery mechanism includes a recovery hole axially penetrating through the sharp portion and a recovery channel extending axially along the catheter. The recovery hole communicates with the recovery channel. The recovery channel and the recovery hole are used for aspirating the content of the target plaque.

8. The plaque treatment device according to claim 7, wherein The content recovery mechanism further includes a plurality of branch holes radially formed in the side wall of the sharp portion along the radial direction of the sharp portion and communicating with the recovery hole. The branch holes allow the content of the target plaque to pass through.

9. The plaque treatment device according to claim 1, wherein The catheter is a multi-lumen tube.

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