Pipeline status detection method and mechanism

Abstract

The present invention provides a pipeline state detection method and mechanism. The pipeline state detection method comprises: obtaining a state signal of a liquid injection pipeline, the state signal comprising a bubble signal value obtained by a pipeline state detection mechanism detecting the liquid injection pipeline; judging whether the bubble signal value is greater than a first preset limit value; when the bubble signal value is greater than the first preset limit value, judging that there are bubbles in the liquid injection pipeline; when the bubble signal value is less than or equal to the first preset limit value, judging that there are no bubbles in the liquid injection pipeline. The present invention solves the problem of high pipeline state detection cost in the prior art.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnostic automation equipment, and in particular to a pipeline status detection method and mechanism. Background Art

[0002] In the existing sample analyzers in the field of in vitro diagnostic medical testing, the substrate liquid is generally injected into the reactor after the steps of distributing the sample and reagent to be tested, mixing, incubating, cleaning and separation, so as to realize the generation and measurement of light signals. The existing pipeline status detection scheme, such as the detection of bubbles in the pipeline, is generally through software counting. When the substrate runs out of the measurable number, it automatically switches to a new substrate bottle or reminds the user to load a new substrate bottle. This scheme may cause bubbles in the pipeline due to insufficient substrate filling, resulting in erroneous detection results. Even if a substrate bubble detection device is used, the substrate bubble detection device is generally installed at the liquid aspiration end. The substrate bottle of one channel needs to correspond to a substrate bubble detection device. When the instrument is equipped with a multi-channel substrate, more substrate bubble detection devices are required, which greatly increases the detection cost.

[0003] As can be seen from the above, the existing technology has the problem of high pipeline status detection cost. Summary of the invention

[0004] The main purpose of the present invention is to provide a pipeline status detection method and mechanism to solve the problem of high pipeline status detection cost in the prior art.

[0005] In order to achieve the above-mentioned purpose, according to one aspect of the present invention, there is provided a pipeline status detection method, comprising: obtaining a status signal of an injection pipeline, the status signal comprising a bubble signal value obtained by a pipeline status detection mechanism for detecting the injection pipeline; judging whether the bubble signal value is greater than a first preset limit value; when the bubble signal value is greater than the first preset limit value, judging that bubbles exist in the injection pipeline; when the bubble signal value is less than or equal to the first preset limit value, judging that there are no bubbles in the injection pipeline.

[0006] Furthermore, the bubble signal value is the cumulative number of AD values ​​less than a preset first threshold value of bubble size obtained by the bubble detection device performing multiple detections on the injection pipeline at preset intervals within a preset time; each time an AD value less than the preset first threshold value of bubble size is detected, it is recorded as 1 bubble signal value.

[0007] Furthermore, the preset time is an action cycle from the start of the injection to the end of the injection.

[0008] Furthermore, the preset interval time is 1 ms to 100 ms.

[0009] Furthermore, the status signal also includes a liquid signal value, and the detection method also includes: determining whether the liquid signal value is greater than a preset second threshold value of the bubble size; when the liquid signal value is less than the preset second threshold value of the bubble size, determining that the injection pipeline is in an empty state; when the liquid signal value is greater than or equal to the preset second threshold value of the bubble size, determining that the injection pipeline is in a liquid state.

[0010] Furthermore, when the liquid signal value is less than the preset second threshold value of the bubble size, determining that the injection pipeline is in an empty state includes: when the liquid signal value is less than the preset second threshold value of the bubble size, the injection pipeline is in an empty state of identification; when the liquid signal value is less than the preset second threshold value of the bubble size for a first preset duration, determining that the injection pipeline is in an empty state.

[0011] Furthermore, when the liquid signal value is greater than or equal to the second threshold value of the preset bubble size, determining that the injection pipeline is in a liquid state includes: when the liquid signal value is greater than or equal to the second threshold value of the preset bubble size, the injection pipeline is in a liquid identification state; when the liquid signal value is greater than or equal to the second threshold value of the preset bubble size and maintains for a second preset duration, determining that the injection pipeline is in a liquid state.

[0012] Furthermore, the detection method also includes: in the identification of the tube empty state and / or the tube empty state, when the liquid signal value is greater than or equal to the preset bubble size second threshold, the injection pipeline is switched to the identification of the liquid state; in the identification of the liquid state, when the liquid signal value is less than the preset bubble size second threshold, the injection pipeline is switched to the identification of the tube empty state or the tube empty state.

[0013] Further, the preset second bubble size threshold is smaller than the preset first bubble size threshold.

[0014] Furthermore, the detection method also includes: judging whether the bubble signal value is greater than a second preset limit value, the second preset limit value is greater than the first preset limit value; when the bubble signal value is greater than the second preset limit value, judging that the injection pipeline is in an empty state.

[0015] Furthermore, the detection method also includes: when the bubble signal value is greater than a first preset limit value, issuing a bubble alarm message to the user; and / or when the injection pipeline is in an empty state, issuing an empty pipeline alarm message to the user.

[0016] According to another aspect of the present invention, a pipeline state detection mechanism is provided, and the pipeline state detection method mentioned above is implemented using the pipeline state detection mechanism. The pipeline state detection mechanism includes: a bracket; a detection element, which is arranged on the bracket and is used to detect bubbles in the injection pipeline; and a cover body, which is connected to the bracket and encloses an accommodating space for accommodating the detection element.

[0017] Furthermore, the detection element has a first notch portion for avoiding the injection pipeline; and / or the bracket has a second notch portion for avoiding the injection pipeline; and / or the cover body has a third notch portion for avoiding the injection pipeline.

[0018] By applying the technical solution of the present invention, a pipeline status detection method includes: obtaining a status signal of the injection pipeline, the status signal including a bubble signal value obtained by a bubble detection mechanism for detecting the injection pipeline; judging whether the bubble signal value is greater than a first preset limit value; judging that bubbles exist in the injection pipeline when the bubble signal value is greater than the first preset limit value; judging that there are no bubbles in the injection pipeline when the bubble signal value is less than or equal to the first preset limit value, thereby setting the pipeline status detection mechanism on the injection pipeline instead of the suction pipeline, detecting whether there are bubbles in the injection pipeline according to the first preset limit value, and accurately judging the bubble situation in the injection pipeline, thereby solving the problem of high pipeline status detection cost in the prior art. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The drawings constituting a part of the present application are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0020] Figure 1 A flow chart showing a pipeline status detection method in a specific embodiment of the present invention is shown;

[0021] Figure 2 A schematic structural diagram showing an angle of a pipeline state detection mechanism in a specific embodiment of the present invention;

[0022] Figure 3 A schematic structural diagram from another angle of a pipeline state detection mechanism in a specific embodiment of the present invention is shown.

[0023] The above drawings include the following reference numerals:

[0024] 10. Bracket; 11. Second notch; 20. Detection element; 21. First notch; 30. Cover; 31. Third notch; 40. Liquid injection pipeline. DETAILED DESCRIPTION

[0025] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0026] It should be noted that, unless otherwise specified, all technical and scientific terms used in this application have the same meanings as commonly understood by ordinary technicians in the technical field to which this application belongs.

[0027] In the present invention, unless otherwise specified, the directional words used, such as "up, down, top, bottom", usually refer to the directions shown in the drawings, or to the components themselves in the vertical, perpendicular or gravity directions; similarly, for ease of understanding and description, "inside and outside" refer to the inside and outside relative to the outline of each component itself, but the above-mentioned directional words are not used to limit the present invention.

[0028] Obviously, the above-described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0029] In order to solve the problem of high pipeline status detection cost in the prior art, the present invention provides a pipeline status detection method and mechanism.

[0030] like Figure 1 As shown, the pipeline status detection method includes: obtaining a status signal of the injection pipeline 40, the status signal including a bubble signal value obtained by the pipeline status detection mechanism for detecting the injection pipeline 40; judging whether the bubble signal value is greater than a first preset limit value; when the bubble signal value is greater than the first preset limit value, judging that there are bubbles in the injection pipeline 40; when the bubble signal value is less than or equal to the first preset limit value, judging that there are no bubbles in the injection pipeline 40.

[0031] By adopting the pipeline state detection method in this embodiment, the pipeline state detection mechanism is set on the injection pipeline 40 instead of the suction pipeline. Even in the case of a multi-channel substrate, there is no need for multiple pipeline state detection mechanisms to complete the pipeline state detection. In addition, whether there are bubbles in the injection pipeline 40 is detected based on a first preset limit value of whether there are bubbles. The bubble situation in the injection pipeline 40 can be accurately judged, which greatly reduces the pipeline state detection cost while also ensuring the detection accuracy.

[0032] In this embodiment, the bubble signal value is the cumulative number of AD values ​​less than the preset bubble size first threshold value obtained by the pipeline state detection mechanism performing multiple detections on the injection pipeline 40 at preset intervals within a preset time. Each time the AD value is detected to be less than the preset bubble size first threshold value, it is recorded as 1 bubble signal value.

[0033] In this embodiment, the preset time is an action cycle from the start of the injection to the end of the injection.

[0034] In this embodiment, the preset interval time is 1 ms to 100 ms.

[0035] In this embodiment, before or while performing the bubble detection, it is also necessary to first or simultaneously detect whether there is liquid in the liquid injection pipeline 40. Specifically, the state signal also includes a liquid signal value, and the detection method also includes: determining whether the liquid signal value is greater than a preset second bubble size threshold; when the liquid signal value is less than the preset second bubble size threshold, determining that the liquid injection pipeline 40 is in an empty state; when the liquid signal value is greater than or equal to the preset second bubble size threshold, determining that the liquid injection pipeline 40 is in a liquid state.

[0036] In this embodiment, when the liquid signal value is less than the preset second threshold value of the bubble size, the injection pipeline 40 is determined to be in an empty state, including: when the liquid signal value is less than the preset second threshold value of the bubble size, the injection pipeline 40 is in an empty state of identification; when the liquid signal value is less than the preset second threshold value of the bubble size for a first preset duration, the injection pipeline 40 is determined to be in an empty state.

[0037] In this embodiment, when the liquid signal value is greater than or equal to the second threshold value of the preset bubble size, the injection pipeline 40 is determined to be in a liquid state, including: when the liquid signal value is greater than or equal to the second threshold value of the preset bubble size, the injection pipeline 40 is in a liquid identification state; when the liquid signal value is greater than or equal to the second threshold value of the preset bubble size and maintains for a second preset duration, the injection pipeline 40 is determined to be in a liquid state.

[0038] That is to say, in order to ensure the accuracy of detection and prevent misjudgment, the injection pipeline 40 needs to maintain a certain period of time in the tube empty state or the liquid state before it can be determined as the tube empty state or the liquid state.

[0039] In this embodiment, the detection method also includes: in the identification of the tube empty state and / or the tube empty state, when the liquid signal value is greater than or equal to the preset bubble size second threshold value, the injection pipeline 40 switches to the identification of the liquid state; in the identification of the liquid state, when the liquid signal value is less than the preset bubble size second threshold value, the injection pipeline 40 switches to the identification of the tube empty state or the tube empty state.

[0040] As can be seen from the above, in this embodiment, the detection of the liquid state in the injection pipeline 40 is real-time. When the liquid signal value is detected to be less than the preset second threshold value of the bubble size, the injection pipeline 40 enters the tube empty identification state. If the state is maintained for a first duration, the injection pipeline 40 is determined to be in the tube empty state; if the liquid signal value is detected again to be greater than or equal to the preset second threshold value of the bubble size in the tube empty identification state, the maintenance time of the tube empty identification state of the injection pipeline 40 is reset and switched to the liquid identification state; in the liquid identification state, if the state is maintained for a second duration, and the injection pipeline 40 is determined to be in the liquid state, that is, the normal state; if the liquid signal value is detected again to be less than the preset second threshold value of the bubble size in the liquid identification state, the maintenance time of the liquid identification state of the injection pipeline 40 is reset and switched to the tube empty identification state. Similarly, even if the injection pipeline 40 is in the tube empty state, if the liquid signal value is detected again to be greater than or equal to the preset second threshold value of the bubble size, the maintenance time of the tube empty state of the injection pipeline 40 is reset and switched to the liquid identification state.

[0041] In this embodiment, the second preset bubble size threshold is smaller than the first preset bubble size threshold.

[0042] In an optional embodiment, the detection method further includes: determining whether the bubble signal value is greater than a second preset limit value, and the second preset limit value is greater than the first preset limit value; when the bubble signal value is greater than the second preset limit value, determining that the injection pipeline 40 is in an empty state. That is to say, in this embodiment, during the pipeline injection process, the pipeline state detection mechanism continuously detects the injection pipeline 40 at a preset interval and cumulatively records the detected bubble signal value. When the accumulated bubble signal value is greater than the first preset limit value, it indicates that there are bubbles in the injection pipeline 40. When the accumulated bubble signal value continues to increase and is greater than the second preset limit value, it indicates that the injection pipeline 40 is in an empty state. Correspondingly, when the bubble signal value is less than or equal to the first preset limit value, it is determined that there are no bubbles in the injection pipeline 40 and it is in a normal state. With the above detection method, it is only necessary to count the accumulated bubble signal values ​​and compare them with the first preset limit value and the second preset limit value, which simplifies the pipeline state detection process while ensuring the detection accuracy, making the detection method more simple and efficient.

[0043] In this embodiment, when the bubble signal value is greater than the first preset limit value, a bubble alarm message is sent to the user. Correspondingly, when the injection pipeline 40 is in an empty state, an empty pipeline alarm message is sent to the user.

[0044] like Figures 2 to 3As shown, the present application also provides a pipeline state detection mechanism, which is used to implement the above pipeline state detection method. The pipeline state detection mechanism includes a bracket 10, a detection element 20 and a cover body 30. The detection element 20 is arranged on the bracket 10, and is used to detect bubbles in the injection pipeline 40. The cover body 30 is connected to the bracket 10 and encloses an accommodation space for accommodating the detection element 20. Through the above arrangement, the bracket 10 can make the detection element 20 suspended to avoid liquid immersion, and the cover body 30 can make the detection element 20 avoid interference from external light, dust, liquid, etc., and provide a stable and reliable detection environment for the detection element 20, thereby ensuring the detection accuracy of the pipeline state detection mechanism.

[0045] like Figures 2 to 3 As shown, the detection element 20 has a first notch portion 21 for avoiding the injection pipeline 40. Correspondingly, the bracket 10 has a second notch portion 11 for avoiding the injection pipeline 40. The cover body 30 has a third notch portion 31 for avoiding the injection pipeline 40. When the pipeline state detection mechanism is used to perform substrate bubble detection, the injection pipeline 40 passes through the second notch portion 11, the first notch portion 21 and the third notch portion 31 in sequence, so that the injection pipeline 40 can pass through the detection element 20, so that the detection element 20 detects whether there are bubbles in the injection pipeline 40.

[0046] In this embodiment, the detection element 20 is a bubble sensor, which detects bubbles by means of a through-beam optical coupling detection method.

[0047] In this embodiment, the pipeline state detection mechanism has an automatic calibration function, and can automatically calibrate a first bubble size threshold for distinguishing the presence or absence of bubbles and a second bubble size threshold for distinguishing the presence or absence of liquid through a self-calibration adjustment algorithm.

[0048] Specifically, the pipeline state detection mechanism also includes a detection circuit board for processing signals, a processing circuit is provided on the detection circuit board, and the detection element 20 is electrically connected to the processing circuit. The detection element 20 can obtain the pipeline state, and the processing circuit amplifies and filters the state signal returned by the detection element 20; the ADC converts the analog signal into a digital signal; then the MCU reads the digital signal of the ADC and makes corresponding judgments according to the preset algorithm, and outputs an analog control signal through the DAC; the analog control signal adjusts the sensitivity of the detection element 20 through a controllable constant current source, thereby realizing the automatic calibration function.

[0049] In this embodiment, in order to improve the detection accuracy, there can be multiple detection elements 20, and the multiple detection elements 20 are arranged at intervals on the bracket 10. When the pipeline state detection mechanism is used to detect substrate bubbles, the injection pipeline 40 passes through the multiple detection elements 20 in sequence, and the detection results of the multiple detection elements 20 confirm each other, thereby improving the detection accuracy.

[0050] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0051] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the numbers used in this way can be interchanged where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein.

[0052] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A pipeline status detection method, characterized in that: include: Acquiring a state signal of the liquid injection pipeline (40), wherein the state signal comprises a bubble signal value detected by a pipeline state detection mechanism on the liquid injection pipeline (40); Determining whether the bubble signal value is greater than a first preset limit value; When the bubble signal value is greater than the first preset limit value, it is determined that bubbles exist in the injection pipeline (40); When the bubble signal value is less than or equal to the first preset limit value, it is determined that there are no bubbles in the injection pipeline (40); The bubble signal value is the cumulative number of AD values ​​less than a preset first threshold value of the bubble size obtained by the pipeline state detection mechanism performing multiple detections on the injection pipeline (40) at preset intervals within a preset time; Each time the AD value is detected to be smaller than the preset first threshold of the bubble size, it is recorded as one bubble signal value.

2. The pipeline status detection method according to claim 1, characterized in that: The preset time is the action cycle from the start of the injection to the end of the injection.

3. The pipeline status detection method according to claim 1, characterized in that: The preset interval time is 1 ms to 100 ms.

4. The pipeline status detection method according to claim 1, characterized in that: The state signal also includes a liquid signal value, and the detection method also includes: Determine whether the liquid signal value is greater than a preset bubble size second threshold; When the liquid signal value is smaller than the preset second bubble size threshold, the injection pipeline (40) is determined to be in an empty state; When the liquid signal value is greater than or equal to the preset second bubble size threshold, it is determined that the injection pipeline (40) is in a liquid-containing state.

5. The pipeline status detection method according to claim 4, characterized in that: When the liquid signal value is less than the preset second bubble size threshold, determining that the injection pipeline (40) is in an empty state comprises: When the liquid signal value is less than the preset second bubble size threshold, the injection pipeline (40) is in an empty tube identification state; When the liquid signal value is less than the preset second threshold value of the bubble size for a first preset duration, it is determined that the injection pipeline (40) is in the tube empty state.

6. The pipeline status detection method according to claim 5, characterized in that: When the liquid signal value is greater than or equal to the preset second bubble size threshold, determining that the injection pipeline (40) is in a liquid state comprises: When the liquid signal value is greater than or equal to the preset second bubble size threshold, the injection pipeline (40) is in a liquid identification state; When the liquid signal value is greater than or equal to the second threshold value of the preset bubble size and is maintained for a second preset duration, it is determined that the injection pipeline (40) is in the liquid-containing state.

7. The pipeline status detection method according to claim 6, characterized in that: The detection method further comprises: In the tube empty identification state and / or the tube empty state, when the liquid signal value is greater than or equal to the preset bubble size second threshold value, the injection pipeline (40) is switched to the liquid identification state; In the liquid identification state, when the liquid signal value is less than the preset bubble size second threshold, the liquid injection pipeline (40) is switched to the tube empty identification state or the tube empty state.

8. The pipeline status detection method according to claim 4, characterized in that: The preset second bubble size threshold is smaller than the preset first bubble size threshold.

9. The pipeline status detection method according to claim 1, characterized in that: The detection method further comprises: Determine whether the bubble signal value is greater than a second preset limit value, the second preset limit value being greater than the first preset limit value; When the bubble signal value is greater than the second preset limit value, it is determined that the injection pipeline (40) is in an empty state.

10. The pipeline status detection method according to claim 9, characterized in that: The detection method further comprises: When the bubble signal value is greater than the first preset limit, a bubble alarm message is sent to the user; and / or When the liquid injection pipeline (40) is in the tube empty state, a tube empty alarm message is sent to the user.

11. A pipeline status detection mechanism, characterized in that: The pipeline state detection mechanism is used to implement the pipeline state detection method according to any one of claims 1 to 10, wherein the pipeline state detection mechanism comprises: Bracket (10); a detection element (20), the detection element (20) being arranged on the support (10) and used for detecting bubbles in the injection pipeline (40); A cover body (30), the cover body (30) is connected to the bracket (10) and encloses a containing space for containing the detection element (20).

12. The pipeline status detection mechanism according to claim 11, characterized in that: The detection element (20) has a first notch portion (21) for avoiding the injection pipeline (40); and / or The support (10) has a second notch (11) for avoiding the injection pipeline (40); and / or The cover body (30) has a third notch portion (31) for avoiding the liquid injection pipeline (40).

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