A rubber stopper cleaning and sterilization device and method for sodium penicillin injection

Abstract

The present invention discloses a rubber plug cleaning and sterilization device and method for sodium penicillin for injection, comprising an outer cylinder and an inner cylinder; the outer cylinder and the inner cylinder are both placed horizontally, the inner cylinder is coaxially arranged inside the outer cylinder; the inner cylinder can rotate around its own axis; both ends of the inner cylinder are provided with telescopic devices, both ends of the inner cylinder are provided with pistons, the output end of the telescopic device extends out of the inner cylinder and is used to drive the piston to move along the length direction of the inner cylinder; within the stroke range of the two pistons, the side wall of the inner cylinder is provided with a plurality of through holes. With this scheme, the pistons move toward each other, so that the steam is sterilized only within a certain spatial range, and the internal steam is always kept at a certain sterilization temperature and pressure range through the pressurization of the piston and the external steam, and the control means are simpler.

Description

Technical Field

[0001] The invention relates to the technical field of medical supplies, and in particular to a device and method for cleaning and sterilizing a rubber stopper of sodium penicillin for injection. Background Art

[0002] Penicillin sodium for injection is indicated for various infections caused by sensitive bacteria, such as abscess, bacteremia, pneumonia and endocarditis. Since penicillin aqueous solution is unstable at room temperature, the potency of 20 units / ml penicillin solution drops by 56% after being placed at 30℃ for 24 hours, and the content of penicillin ene acid increases by 200 times. Therefore, penicillin sodium must be freshly prepared, and the sterile preparation of penicillin sodium's external packaging is particularly important.

[0003] In the prior art, when high-temperature steam sterilization is performed on the rubber plugs in the packaging products, the steam must be in a certain high pressure state and at a certain high temperature to achieve the desired sterilization effect. At this time, too much steam must be rushed into the large-volume container. Due to the large internal space, sufficient steam must be continuously filled and discharged to continuously control the internal temperature and pressure. The sterilization process requires a certain amount of time, resulting in complicated operations when controlling the internal pressure and temperature. Moreover, during this time, the temperature and pressure of the excessive steam will also be difficult to control due to external factors, thereby affecting the sterilization effect of the rubber plug, such as the excessive contact area between the steam and the container wall resulting in heat transfer to the outside, or the precipitation of water inside the rubber plug, which all lead to a decrease in the steam temperature.

[0004] In addition, during the cleaning process of the rubber plugs, all the rubber plugs will be piled up and mixed together for cleaning. After the cleaning balls are added inside, the rubber plugs will be piled up and overlapped, which will result in four cleaning corners left at the rubber plugs, thereby reducing the cleaning effect;

[0005] In summary, there is an urgent need for a device that can improve the cleaning and sterilization effect of rubber stoppers. Summary of the invention

[0006] The present invention aims to solve the above-mentioned deficiencies in sterilization effect and aims to provide a device and method for cleaning and sterilizing rubber stoppers of sodium penicillin for injection. By adopting this scheme, the pistons move toward each other so that the steam is sterilized only within a certain spatial range, and the internal steam is always maintained at a certain sterilization temperature and pressure range through the pressurization of the pistons and the external steam, and the control means is simpler.

[0007] The present invention is achieved through the following technical solutions:

[0008] A rubber stopper cleaning and sterilizing device for sodium penicillin injection, comprising an outer cylinder and an inner cylinder;

[0009] The outer cylinder and the inner cylinder are both placed horizontally, and the inner cylinder is coaxially arranged inside the outer cylinder; the inner cylinder can rotate around its own axis;

[0010] Both ends of the inner cylinder are provided with telescopic devices, both ends of the inner cylinder are provided with pistons, the output end of the telescopic device extends out of the inner cylinder and is used to drive the piston to move along the length direction of the inner cylinder;

[0011] Within the travel range of the two pistons, the side walls of the inner cylinder are each provided with a plurality of through holes.

[0012] Compared with the prior art, in order to flush too much steam into the container, due to the large internal space, sufficient steam must be continuously charged and discharged to continuously control the internal temperature and pressure. The sterilization process takes a certain amount of time, resulting in complicated operations when controlling the internal pressure and temperature. The present invention provides a rubber stopper cleaning and sterilization device for sodium penicillin injection. In the specific scheme, it includes an outer cylinder and an inner cylinder arranged in sequence from the outside to the inside. The outer cylinder and the inner cylinder are both in the shape of a long cylinder and are placed horizontally coaxially. Both ends of the outer cylinder are provided with a cover. Both ends of the outer cylinder are provided with a rotating motor. The rotating motor is driven by The support rod is connected and supported at the covers at both ends of the outer cylinder. The output end of the rotating motor is located inside the support rod and penetrates the covers inside the outer cylinder and at the ends of the inner cylinder, thereby controlling the inner cylinder to rotate around its own axis. A number of rubber plugs are filled in the inner cylinder. When cleaning, purified water can be input into the inner cylinder through the through holes. The purpose of cleaning the rubber plugs is achieved by rotating the inner cylinder. During the cleaning process, as the inner cylinder rotates, some impurities cleaned inside will be exchanged to the outside of the inner cylinder through the through holes, thereby avoiding excessive precipitation of internal impurities. In addition, during the sterilization process, steam is firstly supplied to the outer cylinder through the steam pipe of the outer cylinder. High-temperature and high-pressure steam is filled between the inner cylinder and the inner cylinder. The steam enters the inner cylinder through the through hole. After sufficient steam is filled, the two pistons are driven to move toward each other and cross the through hole, so that the two pistons seal all the rubber plugs in the local sealing area of ​​the inner cylinder. At this time, all the rubber plugs will be sterilized only in a smaller area. According to the real-time pressure detected internally, the two pistons can move toward each other to increase the internal pressure. The pressure control method is simpler. During the sterilization process, the steam can also evaporate part of the solution remaining in the rubber plug, further improving the sterilization effect. At this time, the seeped solution will be evaporated. This causes the internal temperature to drop, and the two pistons move toward each other. By increasing the internal pressure, the temperature of the steam can also be indirectly increased to prevent the temperature from dropping too much. Secondly, at this time, high-temperature and high-pressure steam will remain between the side wall of the outer cylinder and the side wall of the inner cylinder, and between the piston and the inner cylinder cover, thereby ensuring that the external temperature difference is small and preventing the temperature from being lost through the shell. Among them, the outer shell and the inner shell are both made of high-temperature and high-pressure resistant materials, and two telescopic devices are preferably arranged at the inner cylinder cover, and the telescopic device adopts a telescopic motor. A temperature sensor and a pressure sensor are also provided on the inside of the piston to facilitate the detection of temperature and pressure.

[0013] Further optimization is that the inner side of the piston is provided with a plurality of heat insulating rods, the heat insulating rods are arranged along the length direction of the inner cylinder, and gaps for the rubber plug to pass through are left between adjacent heat insulating rods; this is used to achieve dead corners in rubber plug cleaning and sterilization.

[0014] Further optimization, the several heat-insulating rods on the two pistons are respectively surrounded into a ring to form a large ring-shaped heat-insulating rod group and a small ring-shaped heat-insulating rod group, the diameter of the large ring-shaped heat-insulating rod group is larger than the diameter of the small ring-shaped heat-insulating rod group; a gap is left between the inner side of the large ring-shaped heat-insulating rod group and the outer side of the small ring-shaped heat-insulating rod group for the rubber plug to pass through; the sum of the lengths of the heat-insulating rods in the large ring-shaped heat-insulating rod group and the heat-insulating rods in the small ring-shaped heat-insulating rod group is larger than the distance between the two pistons; it is more conducive to separating the rubber plugs.

[0015] Further optimization is that the heat insulation rod is provided with a brush; the cleaning effect of the brush on the rubber plug is improved.

[0016] Further optimization, both ends of the inner cylinder side wall are provided with annular sliders, and both ends of the inner side of the outer cylinder are provided with annular sealing grooves adapted to the annular sliders, and the annular sliders and the annular sealing grooves are slidably connected; they are used to support and guide the rotation of the inner cylinder and isolate the telescopic device.

[0017] Further optimization, the upper side and the lower side middle part of the outer cylinder are respectively provided with a first inlet sealing door and a first outlet sealing door, the side wall of the inner cylinder is respectively provided with a second inlet sealing door and a second outlet sealing door, the first inlet sealing door, the first outlet sealing door, the second inlet sealing door and the second outlet sealing door are all in the same vertical direction; and are used for putting in and taking out the rubber plug.

[0018] Further optimization is that the inner side of the outer cylinder is provided with a limiting cylinder, the limiting cylinder is arranged around the first inlet sealing door, and a position sensor is provided in the limiting cylinder, the position sensor is used to detect the position of the second inlet sealing door; it is used to prevent the plug from entering the gap between the outer cylinder and the inner cylinder, and to position the second inlet sealing door.

[0019] Further optimization is that the positions of the through holes corresponding to the two ends of the lower side of the outer cylinder are both provided with outwardly protruding water outlet grooves, and the water outlet grooves are provided with water outlet valves for facilitating the discharge of the purified water inside.

[0020] Further optimization is that the upper side of the outer cylinder is provided with a vacuum pipe, a water inlet pipe and a steam pipe, and the vacuum pipe, the water inlet pipe and the steam pipe are all connected to the inner cylinder through the through hole; thus avoiding the arrangement of various complex transmission pipelines on the rotating shell, and the equipment line arrangement is simpler and more convenient.

[0021] Further optimized, a method for cleaning and sterilizing a rubber stopper cleaning and sterilizing device for sodium penicillin injection comprises the following steps:

[0022] S1: Add a rubber plug into the inner cylinder;

[0023] S2: The vacuum degree in the outer cylinder and the inner cylinder is reduced to below -0.08MPa;

[0024] S3: introducing purified water into the outer cylinder, so that the purified water enters the inner cylinder through the through hole until the rubber plug is submerged;

[0025] S4: Make the inner cylinder rotate at high speed around its own axis to clean the rubber plug by rolling;

[0026] S5: After the cleaning is completed, the purified water in the outer cylinder is discharged, and high-temperature steam is introduced into the outer cylinder so that the high-temperature steam enters the inner cylinder through the through hole;

[0027] S6: After the high-temperature steam is introduced, the two pistons are driven to move toward each other until the pistons pass over the through hole. At this time, the inner cylinder is controlled to rotate around its own axis at a low speed to sterilize the rubber stopper at high temperature;

[0028] S7: During the high-temperature sterilization process, the internal temperature of the inner cylinder is detected in real time. When the temperature drops, the two pistons are driven to move toward each other until the high-temperature sterilization is completed;

[0029] S8: After high-temperature sterilization is completed, the steam is extracted, the rubber plug is removed, and the cleaning and sterilization is completed.

[0030] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0031] 1. The present invention provides a device and method for cleaning and sterilizing a rubber stopper of sodium penicillin for injection. According to the scheme, the pistons move toward each other so that the steam is sterilized only within a certain spatial range, and the internal steam is always kept within a certain sterilization temperature and pressure range through the pressurization of the pistons and the external steam, and the control means is simpler.

[0032] 2. The present invention provides a device and method for cleaning and sterilizing a rubber stopper of sodium penicillin for injection. According to this scheme, during the sterilization process, the two pistons move toward each other, and by increasing the internal pressure, the temperature of the steam can be indirectly increased to avoid excessive temperature drop; secondly, high-temperature and high-pressure steam will also remain between the side wall of the outer cylinder and the side wall of the inner cylinder, and between the piston and the inner cylinder cover, thereby ensuring that the external temperature difference is small and avoiding the temperature loss through the shell.

[0033] 3. The present invention provides a device and method for cleaning and sterilizing rubber stoppers for sodium penicillin injection. According to this solution, a plurality of rubber stoppers are separated by a plurality of heat-insulating rods, thereby reducing cleaning and sterilization dead corners during the cleaning and sterilization process.

[0034] 4. The present invention provides a device and method for cleaning and sterilizing a rubber stopper of sodium penicillin for injection. By adopting this solution, various pipelines are only arranged on the outside of the outer cylinder, thereby avoiding the arrangement of various complex transmission pipelines on the rotating shell, and the equipment line layout is more simple and convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions of the exemplary embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and should not be regarded as limiting the scope. For those of ordinary skill in the art, other relevant drawings can be obtained based on these drawings without creative work. In the drawings:

[0036] Figure 1 A schematic diagram of the structure of the cleaning state of the cleaning and sterilizing device provided by the present invention;

[0037] Figure 2 An enlarged view of point A of the cleaning and sterilizing device provided by the present invention;

[0038] Figure 3 A schematic diagram of the structure of the sterilization state of the cleaning and sterilization device provided by the present invention;

[0039] Figure 4 A side view of a piston provided by the present invention;

[0040] Figure 5 A side view of another piston provided for the present invention.

[0041] Marks and corresponding parts names in the attached drawings:

[0042] 1-outer cylinder, 11-annular sealing slide, 12-first inlet sealing door, 13-first outlet sealing door, 14-limiting cylinder, 15-water outlet trough, 16-water outlet valve, 17-vacuum pipe, 18-water inlet pipe, 19-steam pipe, 2-inner cylinder, 21-through hole, 22-annular slider, 23-second inlet sealing door, 24-second outlet sealing door, 3-piston, 31-thermal insulation rod, 4-telescopic device, 5-rotating motor. DETAILED DESCRIPTION

[0043] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with embodiments and drawings. The exemplary embodiments of the present invention and their description are only used to explain the present invention and are not intended to limit the present invention.

[0044] Example 1

[0045] A rubber stopper cleaning and sterilizing device for sodium penicillin injection, such as Figure 1 and Figure 5 As shown, it includes an outer cylinder 1 and an inner cylinder 2;

[0046] The outer cylinder 1 and the inner cylinder 2 are both placed horizontally, and the inner cylinder 2 is coaxially arranged inside the outer cylinder 1; the inner cylinder 2 can rotate around its own axis;

[0047] Both ends of the inner cylinder 2 are provided with telescopic devices 4, and both ends of the inner cylinder 2 are provided with pistons 3. The output end of the telescopic device 4 extends out of the inner cylinder 2 and is used to drive the piston 3 to move along the length direction of the inner cylinder 2;

[0048] Within the travel range of the two pistons 3, the side wall of the inner cylinder 2 is provided with a plurality of through holes 21.

[0049] Compared with the prior art, if too much steam is poured into the container, due to the large internal space, sufficient steam must be continuously charged and discharged to continuously control the internal temperature and pressure. The sterilization process takes a certain amount of time, resulting in complicated operations when controlling the internal pressure and temperature. The present invention provides a rubber stopper cleaning and sterilization device for sodium penicillin injection. In the specific scheme, it includes an outer cylinder 1 and an inner cylinder 2 which are arranged in sequence from the outside to the inside. The outer cylinder 1 and the inner cylinder 2 are both in the shape of a long cylinder and are placed horizontally coaxially. Both ends of the outer cylinder 1 are provided with a rotating motor 5, and the rotating motor 5 is connected to the outer cylinder 1 by a support rod. The outer cylinder 1 is supported at the covers at both ends, and the output end of the rotating motor 5 is located in the supporting rod, and penetrates the outer cylinder 1 and the covers at the ends of the inner cylinder 2, so as to control the inner cylinder 2 to rotate around its own axis; a number of rubber plugs are filled in the inner cylinder 2, and when cleaning, purified water can be input into the inner cylinder 2 through the through hole 21, and the purpose of cleaning the rubber plugs is achieved by the rotation of the inner cylinder 2. During the cleaning process, as the inner cylinder 2 rotates, some impurities cleaned inside will be exchanged to the outside of the inner cylinder 2 through the through hole 21, so as to avoid excessive precipitation of internal impurities; in addition, during the sterilization process, the steam pipe 19 of the outer cylinder 1 is firstly used to discharge the steam to the outside, and the steam is discharged to the outside through the steam pipe 19 of the outer cylinder 1. High-temperature and high-pressure steam is filled between the cylinder 1 and the inner cylinder 2. The steam enters the inner cylinder 2 through the through hole 21. After a sufficient amount of steam is filled, the two pistons 3 are driven to move toward each other and pass through the through hole 21, so that the two pistons 3 seal all the rubber plugs in the local sealing area of ​​the inner cylinder 2. At this time, all the rubber plugs will be sterilized only in a smaller area. According to the real-time pressure detected internally, the two pistons 3 can move toward each other to increase the internal pressure, and the pressure control method is simpler. During the sterilization process, the steam can also evaporate part of the solution remaining in the rubber plug, further improving the sterilization effect. At this time, since the seeped solution is evaporated, , which will cause the internal temperature to decrease. The two pistons 3 move toward each other, and by increasing the internal pressure, the temperature of the steam can be indirectly increased to avoid excessive temperature drop. Secondly, at this time, high-temperature and high-pressure steam will remain between the side wall of the outer cylinder 1 and the side wall of the inner cylinder 2, and between the piston 3 and the cover of the inner cylinder 2, thereby ensuring that the external temperature difference is small and avoiding the loss of temperature through the shell. Among them, the outer shell and the inner shell are both made of high-temperature and high-pressure resistant materials, and two telescopic devices 4 are preferably arranged at the cover of the inner cylinder 2, and the telescopic device 4 adopts a telescopic motor. A temperature sensor and a pressure sensor are also provided on the inner side of the piston 3 to facilitate the detection of temperature and pressure.

[0050] See also Figure 1 As a specific implementation method to avoid dead corners in cleaning and sterilizing rubber plugs, the configuration is as follows: a plurality of heat insulating rods 31 are provided on the inner side of the piston 3, the heat insulating rods 31 are arranged along the length direction of the inner cylinder 2, and gaps are left between adjacent heat insulating rods 31 for the rubber plug to pass through;

[0051] It can be understood that in this embodiment, a number of horizontally arranged heat insulating rods 31 are provided on the inner side of the piston 3. During the rotation of the inner cylinder 2, a number of rubber plugs will be separated by the number of heat insulating rods 31, so that the rubber plugs pass through the gaps between adjacent heat insulating rods 31. By separating a number of rubber plugs, dead corners are reduced during the cleaning and sterilization process; the heat insulating rods 31 can also reduce temperature loss.

[0052] See also Figure 4 and Figure 5 As a specific implementation method for more convenient separation of rubber plugs, it is configured as follows: a plurality of heat insulating rods 31 on the two pistons 3 are respectively surrounded in a ring to form a large ring heat insulating rod group and a small ring heat insulating rod group, the diameter of the large ring heat insulating rod group is larger than the diameter of the small ring heat insulating rod group; a gap is left between the inner side of the large ring heat insulating rod group and the outer side of the small ring heat insulating rod group for the rubber plug to pass through; the sum of the lengths of the heat insulating rods 31 in the large ring heat insulating rod group and the heat insulating rods 31 in the small ring heat insulating rod group is larger than the distance between the two pistons 3;

[0053] It can be understood that in the present embodiment, a plurality of heat insulating rods 31 are provided on the inner sides of the two pistons 3, and the plurality of heat insulating rods 31 on one piston 3 are arranged around a large circle, and the plurality of heat insulating rods 31 on the other piston 3 are arranged around a small circle. At this time, the small annular heat insulating rod group can be located inside the large annular heat insulating rod group, and the gap between the large circle and the small circle can allow the rubber plug to pass through. In addition, the heat insulating rods 31 on the large circle and the small circle can be staggered in the radial direction, thereby further separating the plurality of rubber plugs and improving the cleaning and sterilization effects of dead corners; during sterilization, a gap is always left between the outer end of the heat insulating rod 31 and the other piston 3 for the piston 3 to move.

[0054] As a redundant solution, the heat insulating rod 31 is provided with a brush; the cleaning effect of the brush on the rubber plug is improved.

[0055] See also Figure 1 and Figure 2 As a specific embodiment of supporting and guiding the rotation of the inner cylinder 2 and isolating the telescopic device 4, it is set as follows: both ends of the side wall of the inner cylinder 2 are provided with an annular slider 22, and both ends of the inner side of the outer cylinder 1 are provided with an annular sealing groove 11 adapted to the annular slider 22, and the annular slider 22 and the annular sealing groove 11 are slidably connected;

[0056] It can be understood that in this embodiment, a sliding slider is provided on the inner cylinder 2, and the annular slider extends into the annular sealing groove 11 and slides, thereby being similar to the form of a sealing guide rail, and providing rotational support and guidance for the inner cylinder 2; in addition, by providing the annular sealing groove 11, a flow sealing space for purified water and steam is formed between the two annular sealing grooves 11, and the telescopic device 4 at the sealing cover is isolated from the outside to avoid affecting it, and the external flow space for purified water and steam will also be reduced.

[0057] See also Figure 1 As a specific implementation method for inserting and removing the rubber plug, it is configured as follows: the middle of the upper side and the lower side of the outer cylinder 1 are respectively provided with a first inlet sealing door 12 and a first outlet sealing door 13, and the side walls of the inner cylinder 2 are respectively provided with a second inlet sealing door 23 and a second outlet sealing door 24, and the first inlet sealing door 12, the first outlet sealing door 13, the second inlet sealing door 23 and the second outlet sealing door 24 are all in the same vertical direction;

[0058] It can be understood that in the present embodiment, in the same vertical direction, the upper side of the outer cylinder 1 is provided with a first inlet sealing door 12, and the upper side of the inner cylinder is provided with a second inlet sealing door 23. By opening the two sealing doors at the same time, the rubber plug can be placed into the inner cylinder 2. Similarly, by opening the first outlet sealing door 13 and the second outlet sealing door 24 at the same time, the rubber plug can be taken out, and the two pistons 3 can also move toward each other to push the rubber plug out. The sealing doors are conventional sealing doors in the prior art and will not be described in detail here.

[0059] See also Figure 1 As a specific implementation method for preventing the rubber plug from entering the gap between the outer cylinder 1 and the inner cylinder 2 and positioning the second inlet sealing door 23, it is configured as follows: the inner side of the outer cylinder 1 is provided with a limiting cylinder 14, the limiting cylinder 14 is arranged around the first inlet sealing door 12, and a position sensor is arranged in the limiting cylinder 14, and the position sensor is used to detect the position of the second inlet sealing door 23;

[0060] It can be understood that in the present embodiment, a limiting cylinder 14 is provided on the inner side of the outer cylinder 1, and the limiting cylinder 14 is provided at the position of the first inlet sealing door 12 and is arranged around the first inlet sealing door 12, and its length direction is arranged downward, so as to prevent the rubber plug from entering into the gap between the two; in addition, a position sensor is provided at the limiting cylinder 14, and the position sensor is used to detect the position of the second inlet sealing door 23, so as to feed back to the main control, and control the second inlet sealing door 23 to be retained at the same vertical position of the first inlet sealing door 12; its control method is the existing conventional control form, which will not be repeated here.

[0061] See also Figure 1As a specific implementation method for facilitating the release of purified water inside, it is configured as follows: at the positions of the through holes 21 at both ends of the lower side of the outer cylinder 1, there are outwardly convex water outlet grooves 15, and the water outlet grooves 15 are provided with water outlet valves 16;

[0062] It can be understood that in this embodiment, a water outlet groove 15 is provided on the lower side of the outer cylinder 1, and the water outlet groove 15 is located below the through hole 21, so that the purified water inside the inner cylinder 2 can directly fall into the water outlet groove 15, and the purified water inside and around the inner cylinder 2 can be released by opening the water outlet valve 16; wherein, the water outlet groove 15 is convex outwardly in a V-shape, which plays a role in guiding the flow direction; and a water outlet pipe is connected to the bottom of the water outlet valve 16.

[0063] See also Figure 1 In this embodiment, the upper side of the outer cylinder 1 is provided with a vacuum pipe 17, a water inlet pipe 18 and a steam pipe 19, and the vacuum pipe 17, the water inlet pipe 18 and the steam pipe 19 are all connected to the inner cylinder 2 through the through hole 21; the internal vacuum is extracted through the vacuum pipe 17, and purified water and steam are filled into the interior through the water inlet pipe 18 and the steam pipe 19, and steam can also be extracted through the steam pipe 19, which is convenient for process control; the vacuum pipe 17, the water inlet pipe 18 and the steam pipe 19 are existing pipeline equipment; by arranging various pipelines only on the outside of the outer cylinder 1, it is avoided to arrange various complex transmission pipelines on the rotating shell, and the equipment line layout is more concise and convenient.

[0064] Example 2

[0065] This embodiment 2 is further optimized on the basis of embodiment 1, and provides a method for cleaning and sterilizing a rubber stopper cleaning and sterilizing device for sodium penicillin injection, comprising the following specific steps:

[0066] The first step: open the first inlet sealing door 12 and the second inlet sealing door 23, add a number of rubber plugs into the inner cylinder 2, and then close the first inlet sealing door 12 and the second inlet sealing door 23.

[0067] Step 2: Then, the vacuum inside the inner cylinder 2 is extracted through the vacuum pipe 17, and the vacuum degree is reduced to below -0.08MPa, and the vacuum degree is left to stand for a few minutes to observe whether there is any change in the internal vacuum degree until the vacuum degree is stable; this is used to detect the internal sealing effect;

[0068] Step 3: Open the water inlet pipe 18 and add purified water into the outer cylinder 1. The purified water will enter the inner cylinder 2 through the through hole 21 until the purified water submerges all the rubber plugs, and then close the water inlet pipe 18.

[0069] Step 4: Control the two rotating motors 5 to rotate synchronously, so that the inner cylinder 2 rotates around itself at a high speed, the rotation speed is 60±5r / min, and the rolling cleaning is continued for 30min. Figure 1As shown, the four corners can be cleaned through the separation of the heat insulating rod 31, and impurities can be separated through the through hole 21; after the cleaning is completed, the water outlet valve 16 is opened to discharge all the purified water inside.

[0070] Step 5: After the discharge is completed, open the steam pipe 19, rush steam into the outer cylinder 1, and the steam can pass into the inner cylinder 2. When the internal pressure of the inner cylinder 2 is maintained at about 0.4MPa and the temperature is 110-130℃, close the steam pipe 19, and drive the telescopic device 4 to drive the two pistons 3 to move toward each other until they pass through the through hole 21, so that a closed space is formed inside the inner cylinder 2. At this time, the internal pressure of the inner cylinder 2 will increase, but it is also within the sterilization pressure range; then make the inner cylinder 2 rotate around itself at a low speed, and the speed of the low-speed rotation is 10±2r / min; rotate and sterilize at high temperature for 10min, such as Figure 3 As shown; during this process, steam will evaporate the residual moisture between the rubber plugs and the residual moisture seeping out of the rubber plugs. At this time, the internal temperature will decrease. By detecting the temperature in real time, when the temperature decreases, the pistons 3 are controlled to move toward each other again. By increasing the pressure, excessive temperature loss is avoided, thereby achieving a continuous sterilization effect; the heat insulating rod 31 can also avoid sterilization dead corners.

[0071] Step 5: After the high-temperature sterilization is completed, the steam in the sealed space is extracted, and the piston 3 is returned to its original position, and the steam inside the inner cylinder 2 is extracted. Then, the first outlet sealing door 13 and the second outlet sealing door 24 are opened, and the rubber plug is taken out. At this time, the cleaning and sterilization is completed.

[0072] The specific implementation methods described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific implementation method of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A device for cleaning and sterilizing rubber stoppers for sodium penicillin injection, characterized in that: Including outer cylinder (1) and inner cylinder (2); The outer cylinder (1) and the inner cylinder (2) are both placed horizontally, and the inner cylinder (2) is coaxially arranged inside the outer cylinder (1); the inner cylinder (2) can rotate around its own axis; Both ends of the inner cylinder (2) are provided with telescopic devices (4), both ends of the inner cylinder (2) are provided with pistons (3), the output end of the telescopic device (4) extends out of the inner cylinder (2) and is used to drive the piston (3) to move along the length direction of the inner cylinder (2); Within the travel range of the two pistons (3), the side walls of the inner cylinder (2) are each provided with a plurality of through holes (21); The inner side of the piston (3) is provided with a plurality of heat insulating rods (31), the heat insulating rods (31) being arranged along the length direction of the inner cylinder (2), and gaps for the rubber plug to pass through are left between adjacent heat insulating rods (31).

2. The device for cleaning and sterilizing the rubber stopper of sodium penicillin for injection according to claim 1, characterized in that: The plurality of heat insulating rods (31) on the two pistons (3) are respectively arranged in a ring to form a large ring heat insulating rod group and a small ring heat insulating rod group; the diameter of the large ring heat insulating rod group is greater than the diameter of the small ring heat insulating rod group; a gap is left between the inner side of the large ring heat insulating rod group and the outer side of the small ring heat insulating rod group for the rubber plug to pass through; and the sum of the lengths of the heat insulating rods (31) in the large ring heat insulating rod group and the heat insulating rods (31) in the small ring heat insulating rod group is greater than the distance between the two pistons (3).

3. The device for cleaning and sterilizing the rubber stopper of sodium penicillin for injection according to claim 1, characterized in that: The thermal insulation rod (31) is provided with a brush.

4. The device for cleaning and sterilizing the rubber stopper of sodium penicillin for injection according to claim 1, characterized in that: Both ends of the side wall of the inner cylinder (2) are provided with annular sliding blocks (22), and both ends of the inner side of the outer cylinder (1) are provided with annular sealing grooves (11) adapted to the annular sliding blocks (22), and the annular sliding blocks (22) and the annular sealing grooves (11) are slidably connected.

5. The device for cleaning and sterilizing the rubber stopper of sodium penicillin for injection according to claim 1, characterized in that: The upper and lower middle parts of the outer cylinder (1) are respectively provided with a first inlet sealing door (12) and a first outlet sealing door (13); the side walls of the inner cylinder (2) are respectively provided with a second inlet sealing door (23) and a second outlet sealing door (24); the first inlet sealing door (12), the first outlet sealing door (13), the second inlet sealing door (23) and the second outlet sealing door (24) are all in the same vertical direction.

6. The device for cleaning and sterilizing the rubber stopper of sodium penicillin for injection according to claim 5, characterized in that: The outer cylinder (1) has a limiting cylinder (14) on its inner side. The limiting cylinder (14) is arranged around the first inlet sealing door (12). A position sensor is arranged inside the limiting cylinder (14). The position sensor is used to detect the position of the second inlet sealing door (23).

7. The device for cleaning and sterilizing the rubber stopper of sodium penicillin for injection according to claim 1, characterized in that: At the positions of the through holes (21) corresponding to the two ends of the lower side of the outer cylinder (1), there are both outwardly protruding water outlet grooves (15), and the water outlet grooves (15) are provided with water outlet valves (16).

8. The device for cleaning and sterilizing the rubber stopper of sodium penicillin for injection according to claim 1, characterized in that: The upper side of the outer cylinder (1) is provided with a vacuum pipe (17), a water inlet pipe (18) and a steam pipe (19); the vacuum pipe (17), the water inlet pipe (18) and the steam pipe (19) are all connected to the inner cylinder (2) through the through hole (21).

9. The method for cleaning and sterilizing a rubber stopper cleaning and sterilizing device for sodium penicillin injection according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1: Adding a rubber plug into the inner cylinder (2); S2: The vacuum degree in the outer cylinder (1) and the inner cylinder (2) is reduced to below -0.08 MPa; S3: introducing purified water into the outer cylinder (1) so that the purified water enters the inner cylinder (2) through the through hole (21) until the rubber plug is submerged; S4: causing the inner cylinder (2) to rotate at high speed around its own axis to clean the rubber plug by rolling; S5: After the cleaning is completed, the purified water in the outer cylinder (1) is discharged, and high-temperature steam is introduced into the outer cylinder (1), so that the high-temperature steam enters the inner cylinder (2) through the through hole (21); S6: After the high-temperature steam is introduced, the two pistons (3) are driven to move toward each other until the pistons (3) pass through the through hole (21). At this time, the inner cylinder (2) is controlled to rotate at a low speed around its own axis to sterilize the rubber stopper at high temperature; S7: During the high-temperature sterilization process, the internal temperature of the inner cylinder (2) is detected in real time. When the temperature drops, the two pistons (3) are driven to move toward each other until the high-temperature sterilization is completed; S8: After high-temperature sterilization is completed, the steam is extracted, the rubber plug is removed, and the cleaning and sterilization is completed.

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