A kind of hydrogel beauty liquid and preparation method thereof

Abstract

The present invention relates to the field of skin care, and specifically provides a hydrogel beauty liquid and a preparation method thereof, wherein the hydrogel beauty liquid contains a Chinese medicine composition, and the raw materials of the Chinese medicine composition include, by weight, 8-12 parts of gardenia, 8-12 parts of honeysuckle, 16-24 parts of dandelion, 8-12 parts of andrographis paniculata, 8-12 parts of magnolia bark, 8-12 parts of tuckahoe, 8-12 parts of umbelliferae, 8-12 parts of oriental rhizome, 8-12 parts of plantain seeds, 8-12 parts of red beans, 8-12 parts of peach kernels, and 8-12 parts of ligusticum chuanxiong, and the above medicines have the effects of relieving heat and detoxification, cooling blood and removing dampness, and have the effects of significantly improving acne skin and inhibiting Propionibacterium acnes. In addition, the study found that in the formula, gardenia and magnolia bark play a synergistic role, significantly improving the acne removal effect.

Description

Technical Field

[0001] The invention relates to the field of skin care, and in particular to a hydrogel beauty liquid and a preparation method thereof. Background Art

[0002] As a daily skin care product, facial masks are increasingly used in people's daily lives. At present, the main forms of facial masks on the market can be divided into peel-off masks, mud masks, cream masks, gel masks, jelly masks and sheet masks according to the dosage form. The moisture in the mask penetrates into the stratum corneum of the skin, making it soft and increasing its elasticity; the adhesive ingredients or powdered adsorbents in the mask can adhere to dirt, metabolic waste and excessive oil on the skin surface and in the pores, and completely remove them.

[0003] CN105726354B patent discloses a hydrogel mask matrix and its preparation method: the matrix raw materials such as 2% sodium alginate aqueous solution, 56% sodium glycerophosphate aqueous solution, 5% sodium carboxymethyl cellulose aqueous solution, 8% polyvinyl alcohol aqueous solution and 2% chitosan solution are mixed evenly, poured into a mold, then cured in a water bath, and repeatedly frozen and thawed 2 to 4 times. The matrix raw material components used in the present invention are natural, green and harmless components such as biopolymers with excellent biocompatibility and skin affinity, which are safe and harmless to the human body, ensuring that the mask matrix is ​​non-allergenic, and the prepared matrix material has uniformity, good gloss, and jade texture; and the surface viscosity and mechanical strength are suitable, the film forming property and stretchability meet the requirements, and the peeling integrity is good.

[0004] Patent CN104306164B discloses a hydrogel mask for laser treatment and a preparation method thereof, comprising a first release film layer, a hydrogel functional layer and a second release film layer, wherein the hydrogel functional layer is located between the first release film layer and the second release film layer, and the first release film layer is attached to the hydrogel functional layer, and the hydrogel functional layer is attached to the second release film layer, wherein the hydrogel functional layer is formed by attaching a viscous layer and a supporting layer. The hydrogel mask has a high water content, and because the spatial grid structure of the hydrogel material can play a role in controlling the release of water to a certain extent, it can provide a nursing time and effect after laser surgery that is higher than other similar products. However, the above-mentioned mask only has the effect of hydrating and moisturizing, and has no obvious effect on improving or repairing acne skin.

[0005] Therefore, it is very important to further develop a rationally compatible Chinese medicine composition to achieve the effect of improving acne skin. Summary of the invention

[0006] Therefore, in view of the deficiencies in the prior art, an object of the present invention is to provide a hydrogel beauty serum and a preparation method thereof.

[0007] To this end, the present invention provides a traditional Chinese medicine composition. The raw materials of the traditional Chinese medicine composition include, by weight, 8-12 parts of gardenia, 8-12 parts of honeysuckle, 16-24 parts of dandelion, 8-12 parts of andrographis paniculata, 8-12 parts of magnolia bark, 8-12 parts of Poria cocos, 8-12 parts of Polyporus umbellatus, 8-12 parts of Alisma orientalis, 8-12 parts of Plantago seed, 8-12 parts of adzuki bean, 8-12 parts of peach kernel, and 8-12 parts of Chuanxiong.

[0008] Furthermore, in terms of weight, the raw materials of the traditional Chinese medicine composition include 10 parts of gardenia, 10 parts of honeysuckle, 20 parts of dandelion, 10 parts of andrographis paniculata, 10 parts of magnolia bark, 10 parts of Poria cocos, 10 parts of Polyporus umbellatus, 10 parts of Alisma orientalis, 10 parts of Plantago seed, 10 parts of red bean, 10 parts of peach kernel, and 10 parts of Ligusticum chuanxiong.

[0009] The present invention also provides a pharmaceutical preparation, comprising the Chinese medicine composition or the Chinese medicine extract prepared from the Chinese medicine composition, and optionally one or more pharmaceutically acceptable excipients. Among them, the pharmaceutically acceptable excipients are, for example, but not limited to, conventional excipients such as solvents, moisturizers, metal ion chelators, and pH regulators. The solvent may be, but not limited to, water, and the moisturizer may be, but not limited to, glycerol, sodium hyaluronate, sodium alginate, etc. The metal ion chelator can be ethylenediaminetetraacetic acid or its sodium salt.

[0010] The present invention also provides a hydrogel beauty liquid, comprising a Chinese medicine extract prepared from the above-mentioned Chinese medicine composition and a hydrogel matrix in a mass ratio of 50-200:1000;

[0011] Taking the total mass of the hydrogel matrix as 100%, the hydrogel matrix includes 5-10wt% of polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer (PEO-PPO-PEO copolymer) with a weight average molecular weight of 8000-20000, 2.5-5wt% of glycerol, 0.5-1.8wt% of sodium alginate, 0.05-2wt% of sodium hyaluronate, 0.8-1.2wt% of buffer salt, 0.2-0.8wt% of metal ion chelator, and the balance is water.

[0012] Furthermore, in terms of weight, the raw materials of the traditional Chinese medicine extract include 10 parts of gardenia, 10 parts of honeysuckle, 20 parts of dandelion, 10 parts of andrographis paniculata, 10 parts of magnolia bark, 10 parts of Poria cocos, 10 parts of Polyporus umbellatus, 10 parts of Alisma orientalis, 10 parts of Plantago seed, 10 parts of red bean, 10 parts of peach kernel, and 10 parts of Chuanxiong.

[0013] Furthermore, the Chinese medicine extract is obtained by weighing gardenia, honeysuckle, dandelion, andrographis paniculata, magnolia bark, Poria cocos, Polyporus umbellatus, oriental water plantain, plantago, adzuki bean, peach kernel and ligusticum chuanxiong according to selected weight proportions, mixing them and extracting them according to conventional extraction methods or extracting them separately according to conventional extraction methods and then mixing them, and then concentrating and drying them.

[0014] Furthermore, the conventional extraction method includes one or more of decoction extraction, maceration extraction, percolation extraction, reflux extraction, ultrasonic extraction and steam distillation extraction; preferably, water decoction extraction is adopted, the number of extractions is at least 1; and the extraction time is at least 10 minutes.

[0015] Furthermore, the metal ion chelating agent is selected from ethylenediaminetetraacetic acid or its sodium salt.

[0016] The buffer salt may be, but is not limited to, bis(2-hydroxyethyl)amino(trihydroxymethyl)methane (bis-tris buffer salt).

[0017] 3 The present invention also includes a pH adjuster, which is not particularly limited and is well known to those skilled in the art. It can be one or more of citric acid, sodium citrate, acetic acid, sodium acetate, etc., to adjust the pH value of the hydrogel beauty serum to 7-8.

[0018] In the present invention, the water may be deionized water, purified water, distilled water, etc.

[0019] The present invention also provides a method for preparing any of the above-mentioned hydrogel beauty serums, comprising the following steps:

[0020] S1. Preparation of the Chinese herbal medicine extract;

[0021] S2, mixing polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer, glycerol, sodium alginate, sodium hyaluronate, buffer salt, metal ion chelating agent and water to obtain a thermosensitive gel composition;

[0022] S3, mixing the Chinese herbal extract and the thermosensitive gel composition, homogenizing, and adding a metal ion chelating agent to obtain a hydrogel beauty serum.

[0023] Furthermore, the ambient temperature of step S2 and step S3 is below 20° C. (eg, about 10° C.).

[0024] The present invention also provides the use of any of the above-mentioned hydrogel beauty liquids or the hydrogel beauty liquid prepared by the above-mentioned preparation method in the preparation of hydrating, moisturizing and / or antibacterial beauty products and / or beauty products for improving acne and / or acne-prone skin.

[0025] The technical solution of the present invention has the following advantages:

[0026] 1. The Chinese medicine composition provided by the present invention is obtained after repeatedly optimizing the composition and content of the drugs in the compound through clinical research and basic research. Gardenia, honeysuckle, dandelion, and Andrographis are the main drugs, which play the effects of clearing heat and detoxifying, cooling blood; Magnolia bark, Poria, Polyporus, Alisma, Plantago, and Adzuki bean are the ministerial drugs, which clear heat and dampness, and improve wine-cracked face acne; Peach kernel and Chuanxiong are adjuvant drugs, and safflower, peach kernel, and Chuanxiong are the messenger drugs, which promote blood circulation and remove blood stasis, and assist in fading acne marks. The above drugs have the effects of clearing heat and detoxifying, cooling blood and removing dampness, and have the effects of significantly improving acne skin and inhibiting Propionibacterium acnes. In addition, the study found that in the formula, Gardenia and Magnolia bark play a synergistic role, significantly improving the acne effect.

[0027] 2. The hydrogel beauty serum provided by the present invention comprises a Chinese herbal extract and a hydrogel matrix in a mass ratio of 50-200:1000; the Chinese herbal extracts of the present invention have the effects of relieving heat and detoxification, cooling blood and removing dampness after being combined, and have the effects of significantly improving acne skin and inhibiting Propionibacterium acnes. In addition, the study found that in the formula, gardenia and magnolia bark play a synergistic role, significantly improving the acne removal effect.

[0028] Taking the total mass of the hydrogel matrix as 100%, the hydrogel matrix includes 5-10wt% of a polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer with a weight-average molecular weight of 8000-20000, 2.5-5wt% of glycerol, 0.5-1.8wt% of sodium alginate, 0.05-2wt% of sodium hyaluronate, 0.8-1.2wt% of a buffer salt, 0.2-0.8wt% of a metal ion chelator, and the balance is water.

[0029] The study found that the weight average molecular weight of PEO-PPO-PEO is 8000-20000, and the phase transition temperature is between 30 and 40°C. Taking the total mass of the hydrogel matrix as 100%, PEO-PPO-PEO only exhibits sol-gel transition characteristics at a concentration of 5-10% and a temperature between 30 and 40°C. When the concentration is too high, it exists in a non-flowing gel state at room temperature and below, and can only undergo a gel-precipitation transition as the temperature increases; when the concentration is too low, it can only undergo a cold sol-hot sol-precipitation transition as the temperature increases, without going through a gel morphology process. When the copolymer concentration is 5-10%, it exists in a flowable sol state at room temperature and below, which is convenient for storage and carrying. After it is applied to the face, it can undergo a sol-gel transition with body temperature. After 15 minutes of application, it can be torn off the skin surface in pieces.

[0030] By using polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer with a weight average molecular weight of 8000-20000, glycerin, sodium alginate, sodium hyaluronate, buffer salt and metal ion chelating agent in the above-mentioned proportion, the obtained beauty essence is liquid at room temperature. After being applied to the skin surface, it can form a gel layer, has good hydrating and moisturizing effects, is not prone to dripping, does not require a matching engraved tray, and can be used on any skin surface that needs to be moisturized and cleaned according to needs, including but not limited to the face, neck, back, etc., bringing consumers a new sensory experience.

[0031] 3. The hydrogel beauty serum provided by the present invention organically combines the theory of traditional Chinese medicine with the hydrogel matrix, is natural and non-irritating, helps to repair and maintain the skin's natural barrier, protects the skin, and has outstanding professionalism and efficacy compared with traditional facial masks. It has excellent antibacterial effects, can inhibit the growth of microorganisms on the skin surface, significantly improves the condition of acne-prone skin, and has good practicality. DETAILED DESCRIPTION

[0032] The following examples are provided for a better understanding of the present invention, but are not intended to limit the best mode of implementation, nor to limit the content and protection scope of the present invention. Any product identical or similar to the present invention obtained by anyone under the inspiration of the present invention or by combining the features of the present invention with other prior arts shall fall within the protection scope of the present invention.

[0033] If no specific experimental steps or conditions are specified in the examples, the conventional experimental steps or conditions described in the literature in the field can be used. If no manufacturer is specified for the reagents or instruments used, they are all conventional reagent products that can be obtained commercially.

[0034] All medicinal materials passed the inspection and met the standards of the Pharmacopoeia of the People's Republic of China. In the extraction process, the multiple refers to the number of milliliters of water added per gram of Chinese medicinal materials. PEO-PPO-PEO copolymers, with weight-average molecular weights of approximately 5700, 8400, 14000, 18000, and 25000, were purchased from BASF; carrageenan was purchased from Xi'an Taihua Pharmaceutical Technology Co., Ltd.

[0035] Example 1 Hydrogel Beauty Essence

[0036] This embodiment provides a traditional Chinese medicine extract, and its raw materials are as follows: 10g of Gardenia, 10g of Honeysuckle, 20g of Taraxacum, 10g of Andrographis, 10g of Magnolia Bark, 10g of Poria, 10g of Polyporus, 10g of Alisma, 10g of Plantago, 10g of Adzuki Bean, 10g of Peach Kernel, and 10g of Ligusticum chuanxiong.

[0037] Preparation method: Weigh the above medicinal materials according to the prescription, dry, crush, add three times the amount of water and boil for 30 minutes, take the filtrate and concentrate it to contain 1g / mL of crude drug, freeze-dry, and obtain the powdered Chinese medicine extract.

[0038] This embodiment also provides a hydrogel beauty serum, comprising 130 g of the Chinese herbal extract prepared according to the above method and 1000 g of a hydrogel matrix. Each 100 g of the hydrogel matrix comprises 8 g of a PEO-PPO-PEO copolymer having a weight average molecular weight of 14,000, 3 g of glycerol, 0.5 g of sodium alginate, 2 g of sodium hyaluronate, 1 g of bis-tris buffer salt, and 0.5 g of disodium EDTA, with the remainder being water.

[0039] Preparation method: PEO-PPO-PEO copolymer, glycerin, sodium alginate, sodium hyaluronate, buffer salt and water are mixed evenly under the condition of controlling the temperature at about 10°C to obtain a thermosensitive gel composition; the Chinese medicine extract and the thermosensitive gel composition are mixed, homogenized (3000rpm, 10min), disodium EDTA is added, and the pH value is adjusted to 7 with citric acid and sodium citrate. After stirring evenly, the mixture is evacuated, filtered and discharged to obtain a hydrogel beauty serum.

[0040] Example 2 Hydrogel Beauty Essence

[0041] This embodiment provides a traditional Chinese medicine extract, and its raw materials are as follows: 10g of Gardenia, 10g of Honeysuckle, 20g of Taraxacum, 10g of Andrographis, 10g of Magnolia Bark, 10g of Poria, 10g of Polyporus, 10g of Alisma, 10g of Plantago, 10g of Adzuki Bean, 10g of Peach Kernel, and 10g of Ligusticum chuanxiong.

[0042] Preparation method: Weigh the above medicinal materials according to the prescription, dry, crush, add three times the amount of water and boil for 30 minutes, take the filtrate and concentrate it to contain 1g / mL of crude drug, freeze-dry, and obtain the powdered Chinese medicine extract.

[0043] This embodiment also provides a hydrogel beauty serum, comprising 78g of the Chinese herbal extract of this embodiment and 1000g of a hydrogel matrix. The total mass of the hydrogel matrix is ​​100%, wherein the hydrogel matrix comprises 5wt% of a PEO-PPO-PEO copolymer having a weight average molecular weight of 18000, 2.5wt% of glycerol, 1wt% of sodium alginate, 0.1wt% of sodium hyaluronate, 0.8wt% of bis-tris buffer salt, and 0.5wt% of disodium EDTA, and the remainder is water.

[0044] Preparation method: PEO-PPO-PEO copolymer, glycerin, sodium alginate, sodium hyaluronate, buffer salt and water are mixed evenly under the condition of controlling the temperature at about 10°C to obtain a thermosensitive gel composition; the Chinese medicine extract and the thermosensitive gel composition are mixed, homogenized (3000rpm, 10min), disodium EDTA is added, and the pH value is adjusted to 7 with citric acid and sodium citrate. After stirring evenly, the mixture is evacuated, filtered and discharged to obtain a hydrogel beauty serum.

[0045] Example 3 Hydrogel Beauty Essence

[0046] This embodiment provides a traditional Chinese medicine extract, and its raw materials are as follows: 10g of Gardenia, 10g of Honeysuckle, 20g of Taraxacum, 10g of Andrographis, 10g of Magnolia Bark, 10g of Poria, 10g of Polyporus, 10g of Alisma, 10g of Plantago, 10g of Adzuki Bean, 10g of Peach Kernel, and 10g of Ligusticum chuanxiong.

[0047] Preparation method: Weigh the above medicinal materials according to the prescription, dry, crush, add three times the amount of water and boil for 30 minutes, take the filtrate and concentrate it to contain 1g / mL of crude drug, freeze-dry, and obtain the powdered Chinese medicine extract.

[0048] This embodiment also provides a hydrogel beauty serum, comprising 156g of the Chinese herbal extract of this embodiment and 1000g of a hydrogel matrix. The total mass of the hydrogel matrix is ​​100%, wherein the hydrogel matrix comprises 10wt% of a PEO-PPO-PEO copolymer having a weight average molecular weight of 8400, 5wt% of glycerol, 1.8wt% of sodium alginate, 0.05wt% of sodium hyaluronate, 1.2wt% of bis-tris buffer salt, and 0.5wt% of disodium EDTA, and the remainder is water.

[0049] Preparation method: PEO-PPO-PEO copolymer, glycerin, sodium alginate, sodium hyaluronate, buffer salt and water are mixed evenly under the condition of controlling the temperature at about 10°C to obtain a thermosensitive gel composition; the Chinese medicine extract and the thermosensitive gel composition are mixed, homogenized (3000rpm, 10min), disodium EDTA is added, and the pH value is adjusted to 7 with citric acid and sodium citrate. After stirring evenly, the mixture is evacuated, filtered and discharged to obtain a hydrogel beauty serum.

[0050] Comparative Example 1

[0051] This comparative example provides a hydrogel beauty serum, which is basically the same as Example 2, except that the amount of the Chinese herbal extract is different. The amount of the Chinese herbal extract in this comparative example is 0.2 times that of the Chinese herbal extract in Example 1, and the other conditions remain unchanged.

[0052] Comparative Example 2

[0053] This comparative example provides a hydrogel beauty serum, which is basically the same as Example 2, except that the amount of the Chinese herbal extract used is different. The amount of the Chinese herbal extract used in this comparative example is twice that of the Chinese herbal extract used in Example 1, and the other conditions remain unchanged.

[0054] Comparative Example 3

[0055] This embodiment provides a Chinese medicine extract, and its raw materials are as follows: 10g of honeysuckle, 20g of dandelion, 10g of Andrographis paniculata, 10g of Magnolia bark, 10g of Poria cocos, 10g of Polyporus umbellatus, 10g of Alisma orientalis, 10g of Plantago seed, 10g of Adzuki bean, 10g of peach kernel, and 10g of Chuanxiong. The preparation method is the same as that of Example 1.

[0056] This comparative example provides a hydrogel beauty serum, which is basically the same as Example 1, except that the Chinese herbal extract prepared in this example is used, that is, no gardenia is added in the preparation of the Chinese herbal extract, and the other conditions remain unchanged.

[0057] Comparative Example 4

[0058] This embodiment provides a Chinese medicine extract, and its raw materials are as follows: 10g of Gardenia, 10g of Honeysuckle, 20g of Taraxacum, 10g of Andrographis, 10g of Poria, 10g of Polyporus, 10g of Alisma, 10g of Plantago, 10g of Adzuki Bean, 10g of Peach Kernel, and 10g of Ligusticum chuanxiong. The preparation method is the same as that of Example 1.

[0059] This comparative example provides a hydrogel beauty serum, which is basically the same as Example 1, except that the Chinese herbal extract prepared in this example is used, that is, magnolia bark is not added in the preparation of the Chinese herbal extract, and other conditions remain unchanged.

[0060] Comparative Example 5

[0061] This embodiment provides a Chinese medicine extract, and its raw materials are as follows: 10g of honeysuckle, 20g of dandelion, 10g of Andrographis paniculata, 10g of Poria cocos, 10g of Polyporus umbellatus, 10g of Alisma orientalis, 10g of Plantago seed, 10g of Adzuki bean, 10g of peach kernel, and 10g of Chuanxiong. The preparation method is the same as that of Example 1.

[0062] This comparative example provides a hydrogel beauty serum, which is basically the same as Example 1, except that the Chinese herbal extract prepared in this example is used, that is, gardenia and magnolia bark are not added in the preparation of the Chinese herbal extract, and other conditions remain unchanged.

[0063] Experimental Example 1 Screening experiment of copolymer

[0064] 1. The purpose of the experiment is to investigate the effect of the mass content of the copolymer on the performance of the hydrogel beauty serum. In the hydrogel matrix, 3%, 5%, 8%, 10%, and 15% of PEO-PPO-PEO copolymer (weight average molecular weight 14000) and 8% carrageenan were selected as the gelling matrix to replace the 8% PEO-PPO-PEO copolymer in Example 1. The other processes and conditions were the same as those in Example 1, and 6 groups of hydrogel beauty serums were prepared.

[0065] Take 6 groups of hydrogel beauty serums, 100 mL each, and place them in a water bath magnetic stirrer. Put a magnetic stirrer in each sample, adjust the speed to 150 rpm, control the temperature to rise gradually from 20°C, and raise the temperature by 1°C every 5 minutes. If the temperature exceeds 50°C, no more experiments will be conducted. Except for the 6th group, it is observed that as the temperature rises, the rotor speed decreases continuously until the rotor stops rotating, and the solution in the beaker changes from a flowing liquid to a gel state. Record the temperature when the rotor stops rotating, which is the gelation temperature. The results are shown in the table below.

[0066] Group Gel-forming matrix and mass content Gelation temperature (℃) 1 3% PEO-PPO-PEO copolymer 45 2 5% PEO-PPO-PEO copolymer 37 3 8% PEO-PPO-PEO copolymer 35 4 10% PEO-PPO-PEO copolymer 30 5 15% PEO-PPO-PEO copolymer 25 6 8% Carrageenan —

[0067] Therefore, in the hydrogel matrix, the hydrogel beauty serum obtained by selecting 5%-10% PEO-PPO-PEO copolymer by weight is a flowable liquid at a temperature below 30°C, and a gel at a temperature of 30-40°C, close to the temperature of human facial skin. However, carrageenan is difficult to stir under the test conditions of 20-50°C, and cannot undergo liquid-gel transformation, and the gelation time is <20°C.

[0068] 2. The purpose of the experiment was to investigate the effect of the weight average molecular weight of the copolymer on the performance of the hydrogel beauty serum. In the hydrogel matrix, PEO-PPO-PEO copolymers with weight average molecular weights of 5700, 8400, 14000, 18000 and 25000 were selected respectively. The rest of the processes and conditions were the same as those in Example 1. The mass content of the added copolymer was 8 wt %, and 5 groups of hydrogel beauty serums were prepared.

[0069] Take 5 groups of hydrogel beauty serums, 100 mL each, and place them in a water bath magnetic stirrer. Put a magnetic stirrer in each sample, adjust the speed to 150 rpm, control the temperature to rise gradually from 20°C, and raise the temperature by 1°C every 5 minutes. If the temperature exceeds 50°C, no more experiments will be conducted. Except for groups 1 and 5, it is observed that as the temperature rises, the rotor speed continues to decrease until the rotor stops rotating, and the solution in the beaker changes from a flowing liquid to a gel state. Record the temperature when the rotor stops rotating, which is the gelation temperature. Groups 1 and 5 remain in liquid state during the period of 20-50°C. The results are shown in the table below.

[0070] Group Molecular weight of PEO-PPO-PEO copolymer Gelation temperature (℃) 1 5700 ＞50℃ 2 8400 40 3 14000 35 4 18000 31 5 25000 ＞50℃

[0071] Therefore, in the hydrogel matrix, the hydrogel beauty serum obtained by selecting PEO-PPO-PEO copolymers with a weight average molecular weight of 8400-18000 has a temperature-sensitive gelation change between 30 and 40°C, while PEO-PPO-PEO copolymers with a weight average molecular weight of 5700 and 25000 do not show a temperature-sensitive gelation tendency between 20 and 50°C.

[0072] Experimental Example 2: Moisturizing performance of the product

[0073] In an environment of room temperature 25°C and relative humidity 50%RH, the hydrogel beauty liquid prepared in each of Examples 1 to 3 of the present invention and Comparative Examples 1 to 2 was used to conduct a facial application experiment on 100 female volunteers aged 18-40 years old, whose skin was healthy and had no history of allergies. The volunteers were randomly divided into 5 groups, each with 20 volunteers, and the beauty liquid was used once after facial cleaning for 15 minutes. The skin moisture content % after 1h, 4h, and 8h of mask application was detected by MY18-MDS800 skin tester. The moisturizing effect of the product was evaluated by the skin moisture content growth rate = (moisture content after use - moisture content before use) / moisture content before use × 100%.

[0074] At the same time, the volunteers rated the comfort of the product. 4-5 points were relatively comfortable and good; 3 points were average; 1-2 points were not good, with a tingling feeling, etc. All results were averaged.

[0075] The results are shown in the table below.

[0076]

[0077] As can be seen from the above table, the skin moisture content after applying the beauty essences prepared in Examples 1 to 3 of the present invention all reached more than 30%, and the skin moisture content increased significantly. Moreover, after 8 hours, the skin moisture content can still be maintained at a high level, and the moisturizing effect is significant and lasting, which is significantly improved compared with Comparative Example 1. The skin moisture content of Comparative Example 2 also increased significantly, but volunteers reported that they felt a tingling sensation during use, and the comfort sensory score was low, which was caused by the excessively high concentration of the Chinese medicine extract.

[0078] Experimental Example 3 Antibacterial Experiment

[0079] Detection of antibacterial effect on Propionibacterium acnes:

[0080] Take the freeze-dried powder of Propionibacterium acnes, add physiological saline and stir evenly, inoculate on the plate containing culture medium, and culture under anaerobic conditions at 37°C for 3 to 4 days. Use an inoculation loop to scrape the slant colony and dilute it to 10 with physiological saline. 6 ~10 7 CFU / mL.

[0081] Take 20 g of each of the Chinese herbal medicine extracts of Example 1 and Comparative Examples 3 to 5, add 20 ml of sterile physiological saline and mix well to prepare a test solution.

[0082] Under aseptic operation, take the cultured bacterial suspension and spread it evenly on the culture medium with a spreading rod. Use the Oxford cup method (outer diameter 8mm) to compare the effective inhibition zones. Add 300μL of the test solution, culture at 37℃ anaerobically for 48h, and measure the diameter of the effective inhibition zone in each culture medium. In addition to the test solution, there is a blank control group: add 300μL of sterile saline, culture at 37℃ for 48h, and take out; a positive control group: add 300μL of 1wt% sodium benzoate, culture at 37℃ anaerobically for 48h, and take out. Criteria for judging the antibacterial effect: an inhibition zone diameter of >20mm is highly sensitive and can effectively inhibit bacteria; an inhibition zone diameter of 10-20mm is moderately sensitive and has a certain antibacterial effect; an inhibition zone of <10mm has almost no antibacterial effect. (The average of the results of 3 independent experiments is taken)

[0083] project Diameter of inhibition zone (mm, n=3) Example 1 24.3±0.5mm Comparative Example 3 11.2±0.8mm Comparative Example 4 9.3mm±0.6mm Comparative Example 5 8.1mm±0.3mm Blank control group 0 1% Sodium Benzoate 20.7±0.5mm

[0084] As can be seen from the above table, the Chinese herbal extracts in the hydrogel beauty serum of the present invention have a significant inhibitory effect on Propionibacterium acnes, among which Gardenia jasminoides and Magnolia bark have a synergistic effect in inhibiting Propionibacterium acnes. The antibacterial effect of the composite is significantly better than that of the single compound.

[0085] Experimental Example 4: The therapeutic effect of the product on improving acne-prone skin

[0086] 1. Sample: the hydrogel beauty serum of Example 1 and Comparative Examples 3 to 5.

[0087] 2. Experimental method: 120 females aged 18 to 40 with acne on their facial skin were selected and randomly divided into 4 groups. Each group of hydrogel beauty serum was used once every night after facial cleansing, about 15g, and applied evenly on the face for about 15 minutes. The treatment lasted for 2 months. Other basic skin care products were the same during this period.

[0088] 3. Evaluation criteria

[0089] Cured: No new acne for one week;

[0090] Significant effect: Acne is significantly improved after use, with few or occasional new acne.

[0091] Ineffective: No obvious effect after use;

[0092] Total effective rate = (marked effect + cure) / total number of cases.

[0093] 4. Results

[0094] The clinical efficacy is as follows:

[0095] project Total number of cases Invalid / Example Significantly effective / case Cured / case Total Effectiveness Example 1 30 2 3 25 93.3％ Comparative Example 3 30 16 8 6 46.7％ Comparative Example 4 30 19 7 4 36.7％ Comparative Example 5 30 24 5 1 20.0％

[0096] As can be seen from the table above, the hydrogel beauty liquid prepared in Example 1 of the present invention has the effect of significantly improving acne skin. According to user feedback, the hydrogel beauty liquid of the present invention is easy to use, has good skin comfort, and has no irritation or allergic reaction after long-term use. However, the effects of the hydrogel beauty liquids prepared in Comparative Examples 3 to 5 are greatly reduced.

[0097] The hydrogel liquid provided by the present invention organically combines the theory of traditional Chinese medicine with a facial mask, is natural and non-irritating, helps to repair and maintain the skin's natural barrier, and protects the skin. Compared with traditional facial masks, it has outstanding professionalism and efficacy, has excellent antibacterial effects, can inhibit the growth of microorganisms on the skin surface, and can improve acne skin.

[0098] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. A Chinese medicine composition, characterized in that: In terms of weight, the raw materials of the traditional Chinese medicine composition are composed of: 8-12 parts of gardenia, 8-12 parts of honeysuckle, 16-24 parts of dandelion, 8-12 parts of andrographis paniculata, 8-12 parts of magnolia bark, 8-12 parts of Poria cocos, 8-12 parts of Polyporus umbellatus, 8-12 parts of Alisma orientalis, 8-12 parts of Plantago seed, 8-12 parts of adzuki bean, 8-12 parts of peach kernel, and 8-12 parts of Ligusticum chuanxiong.

2. The Chinese medicine composition according to claim 1, characterized in that: In terms of weight, the raw materials of the traditional Chinese medicine composition are composed of the following: 10 parts of gardenia, 10 parts of honeysuckle, 20 parts of dandelion, 10 parts of andrographis, 10 parts of magnolia bark, 10 parts of Poria, 10 parts of Polyporus, 10 parts of Alisma, 10 parts of Plantago, 10 parts of red bean, 10 parts of peach kernel, and 10 parts of Chuanxiong.

3. A pharmaceutical preparation, characterized in that It comprises the Chinese medicine composition according to claim 1 or 2 or the Chinese medicine extract prepared from the Chinese medicine composition according to claim 1 or 2, and optionally one or more pharmaceutically acceptable excipients.

4. A hydrogel beauty serum, characterized in that: Comprising a Chinese medicine extract prepared from the Chinese medicine composition according to claim 1 or 2 and a hydrogel matrix in a mass ratio of 50-200:1000; Taking the total mass of the hydrogel matrix as 100%, the hydrogel matrix includes 5-10wt% of a polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer with a weight average molecular weight of 8000-20000, 2.5-5wt% of glycerol, 0.5-1.8wt% of sodium alginate, 0.05-2wt% of sodium hyaluronate, 0.8-1.2wt% of a buffer salt, 0.2-0.8wt% of a metal ion chelator, and the balance is water.

5. The hydrogel beauty serum according to claim 4, characterized in that: The Chinese medicine extract is prepared by weighing gardenia, honeysuckle, dandelion, andrographis paniculata, magnolia bark, Poria cocos, Polyporus umbellatus, oriental water chestnut, plantain seed, adzuki bean, peach kernel and ligusticum chuanxiong according to selected weight proportions, mixing them and then boiling them in water for extraction or boiling them in water separately and then mixing them, and then concentrating and drying them.

6. The hydrogel beauty serum according to claim 5, characterized in that: The extraction method is to add water and decoct, and the extraction number is at least 1 time; the extraction time is at least 10 minutes.

7. The hydrogel beauty serum according to any one of claims 4 to 6, characterized in that: The metal ion chelating agent is selected from ethylenediaminetetraacetic acid or its sodium salt; and / or the pH value of the hydrogel beauty serum is 7-8.

8. A method for preparing the hydrogel beauty serum according to any one of claims 4 to 7, characterized in that: The steps include: S1. Preparation of the Chinese herbal medicine extract; S2, mixing polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer, glycerol, sodium alginate, sodium hyaluronate, buffer salt and water to obtain a thermosensitive gel composition; S3, mixing the Chinese herbal extract and the thermosensitive gel composition, homogenizing, and adding a metal ion chelating agent to obtain a hydrogel beauty serum.

9. The method for preparing the hydrogel beauty serum according to claim 8, characterized in that: The ambient temperature in step S2 and step S3 is 20° C. or lower.

10. Use of the Chinese medicine composition according to claim 1 or 2, the pharmaceutical preparation according to claim 3, the hydrogel beauty lotion according to any one of claims 4 to 7, or the hydrogel beauty lotion prepared by the preparation method according to claim 8 or 9 in preparing a hydrating, moisturizing and / or antibacterial beauty product and / or a beauty product for improving acne and / or acne-prone skin.

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