Reagent system capable of temporary kit assembly

Abstract

The application discloses a reagent system capable of temporarily mounting and dismounting a kit, comprising: a reagent bin, the top of which is provided with an exchange channel; a temporary mounting and dismounting module, which is installed on the top of the reagent bin, and a plurality of mounting positions are distributed on the temporary mounting and dismounting module, each of the mounting positions is used for placing a kit, wherein at least one of the mounting positions is provided with a mixing assembly, and the mixing assembly is used for uniformly mixing a magnetic bead bottle; the temporary mounting and dismounting module is provided with a mechanical gripper and a driving device for controlling the movement of the mechanical gripper, under the driving of the driving device, the mechanical gripper can transfer the kit between the mounting positions or make the kit enter or exit the reagent bin from the exchange channel. The application has the beneficial effect that the kit can be replaced on line without stopping, which helps to ensure that a chemiluminescence immunoassay analyzer realizes large-batch and high-efficiency detection.

Description

TECHNICAL FIELD

[0001] The present application relates to a chemiluminescence immunoassay analyzer, in particular to a reagent system capable of temporarily loading and unloading a kit. BACKGROUND

[0002] Chemiluminescence immunoassay is a new analysis method combining magnetic separation technology, chemiluminescence technology and immunoassay technology, which has the advantages of high accuracy, high sensitivity, short detection time, wide detection range and no pollution, and is widely used in hospital clinical diagnosis and other fields.

[0003] In the physical structure of the chemiluminescence immunoassay analyzer, several modules such as a reagent system, a sample adding system, a washing system and an incubation system are usually included. Among them, the role of the reagent system is to provide the reagent components and magnetic beads required for detection inside the analyzer.

[0004] In the prior art, the reagent system includes a reagent bin, a circular reagent tray is rotatably arranged in the reagent bin, reagent components and magnetic beads are respectively arranged in reagent bottles and magnetic bead bottles, and the reagent bottles and magnetic bead bottles are installed on the reagent tray through a transfer carrier kit. With the rotation of the reagent tray in the reagent bin, reagent components and magnetic beads can be provided to the inside of the chemiluminescence immunoassay analyzer.

[0005] At present, with the rapid increase of detection demand, full-automatic chemiluminescence immunoassay analyzers with higher detection efficiency are favored by the market, and based on this, the applicant is also actively developing related equipment. Since the loading capacity of the reagent kit of the reagent system is always limited, in order to ensure that the chemiluminescence immunoassay analyzer has higher detection efficiency, the reagent system needs to be able to perform online reagent kit loading without stopping. The traditional reagent system does not have this function. SUMMARY

[0006] In view of the above status, the purpose of the present application is to provide a reagent system capable of temporarily loading and unloading a kit, so as to help the chemiluminescence immunoassay analyzer have higher detection efficiency.

[0007] To achieve the above purpose, the technical scheme of the present application is as follows:

[0008] A reagent system capable of temporarily loading and unloading a kit, the key of which is that it comprises:

[0009] a reagent bin, the top of which is provided with an exchange channel;

[0010] a temporary loading and unloading module installed on the top of the reagent bin, a plurality of mounting positions are distributed on the temporary loading and unloading module, each mounting position is used for placing a reagent kit, and at least one mounting position is provided with a mixing assembly for uniformly mixing the magnetic bead bottles;

[0011] The temporary loading and unloading module is provided with a mechanical gripper and a driving device for controlling the movement of the mechanical gripper. Under the driving of the driving device, the mechanical gripper can transfer the reagent box between the installation positions or make the reagent box enter or exit the reagent bin from the exchange channel.

[0012] Preferably, the temporary loading and unloading module comprises a base fixedly assembled on the top of the reagent bin, the base is provided with a taking and placing hole for exposing the exchange channel, and the installation positions and the exchange channel are circularly distributed on the same circumference.

[0013] The driving device comprises a crossbeam, a cantilever rotatably installed below the crossbeam, and a rotary driving assembly for driving the rotation of the cantilever. The crossbeam is movably arranged above the base by a lifting module. The rotation center line of the cantilever coincides with the center line of the circumference on which the installation positions are circularly distributed. The mechanical gripper is arranged at the distal end of the cantilever.

[0014] Preferably, each installation position is in the form of a clamping groove arranged on the base, including a recycling buffer position, a manual recycling position, a manual placing position, a first mixing position, a second mixing position, a magnetic attraction position and a temporary placing position. The side of the magnetic attraction position is provided with a fixed block, and a magnetic element is embedded in the fixed block.

[0015] Preferably, the mixing assembly comprises two sets of mixing seats and a mixing motor for driving the simultaneous rotation of the two sets of mixing seats. The two sets of mixing seats are rotatably installed one by one below the first mixing position and the second mixing position.

[0016] Preferably, the mechanical gripper comprises a guide rail fixedly installed below the distal end of the cantilever, a first clamping arm and a second clamping arm slidably connected to the guide rail, and a clamping motor for driving the first clamping arm and the second clamping arm to move closer to or away from each other. The first sensor and the second sensor are respectively fixedly installed at the two ends of the guide rail. The first clamping arm is provided with a first light shield matched with the first sensor, and the second clamping arm is provided with a second light shield matched with the second sensor. The length of the second light shield is greater than that of the first light shield.

[0017] Preferably, the base movably has a cover plate arranged in the taking and placing hole. The cover plate is used for sealing the exchange channel.

[0018] Preferably, the inner end of the cover plate is rotatably installed on the base through a rotating shaft. The center line of the rotating shaft coincides with the rotation center line of the cantilever. The upper side of the cover plate is provided with a first positioning block and a second positioning block, and the lower side is provided with a limiting protrusion matched with the exchange channel. The cover plate is movable up and down relative to the rotating shaft.

[0019] The first clamping arm and the second clamping arm can place the limiting protrusion of the cover plate into the exchange channel or take the limiting protrusion out of the exchange channel by clamping the first positioning block and the second positioning block.

[0020] Preferably, a torsional spring is sleeved on the rotating shaft, and the torsional spring applies a force to the cover plate to rotate the cover plate to one side when the limiting protrusion is located in the exchange channel.

[0021] Preferably, a third sensor is installed on the base, the height of the first positioning block exceeds the third sensor, and the first positioning block can block the light sensing signal of the third sensor when the cover plate is in the open position.

[0022] Preferably, the reagent bin comprises a bin body and a bin cover, and the bin cover is provided with a regular placement hole and the exchange channel.

[0023] The present application has the following beneficial effects:

[0024] Under the transfer action of the mechanical gripper and the driving device of the temporary loading and unloading module, the reagent box can be taken out of or placed into the reagent bin through the exchange channel, so that the reagent box can be replaced online without stopping, which helps to ensure that the chemiluminescence immunoassay analyzer can realize large-batch and high-efficiency detection. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 A structural schematic diagram of a reagent system provided by the present application is shown in the figure;

[0026] Figure 2 Another structural schematic diagram of a reagent system provided by the present application is shown in the figure;

[0027] Figure 3 A schematic diagram showing the internal structure of the bin body 11 of the reagent bin 1 is shown in the figure;

[0028] Figure 4 A structural schematic diagram of the temporary loading and unloading module A is shown in the figure;

[0029] Figure 5 A top view of the temporary loading and unloading module A is shown in the figure;

[0030] Figure 6 A rotating sectional view along the line A-A is shown in the figure; Figure 5

[0031] A structural schematic diagram of the mixing assembly 3 is shown in the figure; Figure 7

[0032] A structural schematic diagram of the mechanical gripper 4 is shown in the figure; Figure 8

[0033] A structural schematic diagram of the reagent system after hiding the mechanical gripper 4 and the driving device 5 is shown in the figure; Figure 9

[0034] A structural schematic diagram of the reagent system after hiding the mechanical gripper 4 and the driving device 5 is shown in the figure;Figure 10 For Figure 9 A local enlarged schematic view of the part I. DETAILED DESCRIPTION

[0035] The present application is further illustrated in conjunction with the embodiments and the accompanying drawings.

[0036] As Figure 1 and 2 shown, a reagent system capable of temporarily loading and unloading a kit, the system mainly comprises a reagent bin 1 and a temporary loading and unloading module A. In combination with the accompanying drawings, Figure 3 and 9 It can be seen that the reagent bin 1 is in a cylindrical structure, which comprises a bin body 11 and a bin cover 12 fixed on the upper end of the bin body 11, and a reagent tray 13 is rotatably arranged inside the bin body 11, and the reagent tray 13 is automatically selected by an electric control program. The bin cover 12 is provided with a regular placement hole 1b and an exchange channel 1a. When the chemiluminescence immunoassay analyzer is stopped, the kit B can be placed on the reagent tray 13 from the regular placement hole 1b by manual operation. When the chemiluminescence immunoassay analyzer is working online, the kit B can be placed on the reagent tray 13 from the exchange channel 1a by the temporary loading and unloading module A.

[0037] Again as Figure 4 and 5 shown, the temporary loading and unloading module A is installed on the top of the reagent bin 1, and a plurality of installation sites 2 are distributed on the temporary loading and unloading module A, and each installation site 2 is used for placing the kit B. In addition, the temporary loading and unloading module A is also provided with a mechanical gripper 4 and a driving device 5 for controlling the movement of the mechanical gripper 4, and under the driving of the driving device 5, the mechanical gripper 4 can transfer the kit B between the installation sites 2, or make the kit B enter or exit the reagent bin 1 from the exchange channel 1a.

[0038] Based on the above structural layout of the above reagent system, after the kit B is placed on the installation site 2 by manual operation, the mechanical gripper 4 grabs the kit B, and then puts the kit B into the reagent tray 13 inside the reagent bin 1 from the exchange channel 1a. Conversely, the mechanical gripper 4 can also take out the used kit B on the reagent tray 13 to the installation site 2, and then complete the recovery by manual operation. Because the above taking and placing process of the kit is completed by the electric control of the driving device 5 and the mechanical gripper 4, for the whole reagent system, the reagent tray 13 can be ensured to be in a non-rotating stationary state during taking and placing, so that the kit can be replaced online without stopping by such a way, and then the chemiluminescence immunoassay analyzer can realize large batch and high efficiency detection.

[0039] Please refer to Figure 5As shown, each mounting position 2 on the temporary loading and unloading module A has different purposes, in this embodiment, the mounting positions 2 are seven in total, which are: a recycling buffer position a, a manual recycling position b, a manual placing position c, a first mixing position d, a second mixing position e, a magnetic attraction position f and a temporary placing position g. Among them, the first mixing position d and the second mixing position e are provided with a mixing assembly 3, and the mixing assembly 3 is further combined with the magnetic attraction position f to form a magnetic mixing assembly 3, which will be described below. Figure 6 And 7 As can be seen, the mixing assembly 3 includes a mixing motor 3b and two sets of mixing seats 3a, and the two sets of mixing seats 3a are correspondingly and rotatably installed below the first mixing position d and the second mixing position e. The mixing motor 3b can drive the two sets of mixing seats 3a to rotate through the belt. After the reagent box B is placed on the first mixing position d and the second mixing position e, the mixing motor 3b drives the mixing seat 3a to rotate, so that the magnetic bead bottle C in the reagent box B can be mixed and treated, thereby ensuring that the magnetic bead bottle C placed in the reagent bin meets the use requirements of the reagent.

[0040] Further, a fixed block 61 is arranged on the side of the magnetic attraction position f, and a magnetic element 6b is embedded in the fixed block 61. After the reagent box B is placed on the magnetic attraction position f, the height of the magnetic element 6b is close to the middle part of the magnetic bead bottle C, so that the magnetic particles in the magnetic bead bottle C can float up. After the magnetic particles float up, the reagent box B is transferred to the first mixing position d or the second mixing position e for mixing treatment, which can significantly improve the mixing effect of the magnetic particles.

[0041] As shown in FIGS. 1, 2 and 3, Figure 4 And 9 As shown, the temporary loading and unloading module A includes a base 6 fixedly assembled on the top of the reagent bin 1, and the seven mounting positions 2 are arranged in the form of clamping grooves on the base 6. After the temporary loading and unloading module A is fixed on the top of the reagent bin 1, the seven mounting positions 2 and the exchange channel 1a are circularly distributed on the same circumference. In order to ensure that the reagent box B enters and exits the reagent bin 1 from the exchange channel 1a, the base 6 is provided with a taking and placing hole 6a at a position corresponding to the exchange channel 1a. After the base 6 is fixed on the top of the reagent bin 1, the taking and placing hole 6a can ensure that the exchange channel 1a is not blocked. The driving device 5 includes a cross beam 5b, a cantilever 5d rotatably installed below the cross beam 5b, and a rotary driving assembly 5c for driving the cantilever 5d to rotate. The cross beam 5b is movably arranged above the base 6 through a lifting module 5a, the rotation center line of the cantilever 5d coincides with the center line of the circumference where the mounting positions 2 are circularly distributed, and the mechanical gripper 4 is arranged at the distal end of the cantilever 5d. In this embodiment, the rotation center line of the cantilever 5d and the center line of the circumference where the mounting positions 2 are circularly distributed are both position 9 in FIG. 4. Figure 5

[0042] ​Based on the above distribution structure, rotating the cantilever 5d driven by the rotating driving assembly 5c can drive the mechanical gripper 4 to rotate, and combining with the up-down movement of the lifting module 5a, the transfer operation of the reagent box B between the various installation positions 2, the manual placement position c and the exchange channel 1a, and the exchange channel 1a and the manual recycling position b can be realized. Obviously, such design also has the technical advantages of less space occupation and high compactness.

[0043] In the present embodiment, the rotating driving assembly 5c is a motor belt driving mechanism, and the lifting module 5a is a lead screw motor linear lifting mechanism, and the working principles of both are existing mature technical means, which will not be described here.

[0044] Please refer to Figure 8 As shown in the figure, the lower end of the cantilever 5d is fixedly provided with a guide rail 4d. In the present embodiment, the mechanical gripper 4 includes a clamping motor 4c and a first clamping arm 4a and a second clamping arm 4b slidably connected to the guide rail 4d. The clamping motor 4c drives the first clamping arm 4a and the second clamping arm 4b to move closer to or away from each other, thereby completing the grabbing of the reagent box B.

[0045] Please refer to Figure 9 、 10 As shown in the figure, the base 6 is movably provided with a cover plate 7 in the taking and placing hole 6a. The cover plate 7 is used to seal the exchange channel 1a, so as to ensure the stability of the internal environment of the reagent compartment.

[0046] The present embodiment provides an installation structure capable of opening and closing the cover plate 7 by the mechanical gripper 4 when replacing the reagent box online, which is as follows: the inner end of the cover plate 7 is rotatably installed on the base 6 through a rotating shaft 7e, the axis line of the rotating shaft 7e coincides with the rotation center line of the cantilever 5d, the upper side of the cover plate 7 is provided with a first positioning block 7a and a second positioning block 7b, and the lower side is provided with a limiting protrusion 7c adapted to the exchange channel 1a, and the cover plate 7 can move up and down relative to the rotating shaft 7e. A torsional spring 7d is sleeved on the rotating shaft 7e. When the limiting protrusion 7c is located in the exchange channel 1a, the torsional spring 7d exerts a force on the cover plate 7 to rotate it to one side. In the closed state of the cover plate 7, the limiting protrusion 7c is located in the exchange channel 1a. The opening process of the cover plate 7 is as follows: the first clamping arm 4a and the second clamping arm 4b of the mechanical gripper 4 clamps the first positioning block 7a and the second positioning block 7b, and then lifts upward to make the limiting protrusion 7c disengage from the exchange channel 1a, and then releases the clamping force, and then the torsional spring 7d drives the cover plate 7 to rotate to one side, so as to leave the exchange channel 1a. The closing process of the cover plate 7 is as follows: the mechanical gripper 4 clamps the first positioning block 7a and the second positioning block 7b, and then rotates clockwise to make the cover plate 7 rotate above the exchange channel 1a, and then the mechanical gripper 4 moves downward to embed the limiting protrusion 7c into the exchange channel 1a, thereby realizing the closing operation.

[0047] Further, in order to better judge the working state of the mechanical grabber 4, three groups of photoelectric sensors are arranged on the temporary loading and unloading module A.

[0048] Please refer to Figure 8 The first sensor 4e and the second sensor 4f are respectively fixedly installed at two ends of the guide rail 4d, the first light shielding piece 4g matched with the first sensor 4e is arranged on the first clamping arm 4a, the second light shielding piece 4h matched with the second sensor 4f is arranged on the second clamping arm 4b, the length of the second light shielding piece 4h is greater than that of the first light shielding piece 4g, and the signal of the second sensor 4f is blocked first than the first sensor 4e in the opening process of the mechanical grabber 4. Please refer to Figure 10 The third sensor 6c is installed on the base 6, the height of the first positioning block 7a exceeds the third sensor 6c, and the light sensing signal of the third sensor 6c can be blocked by the first positioning block 7a when the cover plate 7 is in the open position.

[0049] With the above three groups of sensors, the following four states of the mechanical grabber 4 can be judged:

[0050] 1. Fully open state: the first sensor 4e and the second sensor 4f have no signal.

[0051] 2. Reagent box grabbing state: the first sensor 4e has a signal, and the second sensor 4f has no signal.

[0052] 3. Cover plate grabbing state: the first sensor 4e and the second sensor 4f have signals, and the third sensor 6c has no signal.

[0053] 4. Fully closed state: the first sensor 4e and the second sensor 4f have signals.

[0054] Through the arrangement of the three groups of sensors, the system can self-check and judge whether the clamped object and each installation position exist reagent boxes when starting. In addition, during the system working process, feedback can be combined with the whole reagent system to complete the online replacement of the reagent box.

[0055] Finally, it should be noted that the above description is only for the preferred embodiments of the present application, and those skilled in the art can make various similar modifications under the inspiration of the present application without departing from the purpose and scope of the present application. Such changes fall within the protection scope of the present application.

Claims

1. A reagent system capable of being temporarily disassembled, characterized in that, The utility model relates to a reagent warehouse temporary loading and unloading module and reagent warehouse temporary loading and unloading method, including: Reagent warehouse (1) top is provided with exchange channel (1a); Temporary loading and unloading module (A) is installed in reagent warehouse (1) top, and temporary loading and unloading module (A) is distributed with a plurality of installation sites (2), and each installation site (2) is used to place reagent box (B), wherein at least one installation site (2) is provided with mixing assembly (3), and mixing assembly (3) is used to shake even processing to magnetic bead bottle (C); Temporary loading and unloading module (A) is provided with mechanical gripper (4) and drive arrangement (5) of control mechanical gripper (4) movement, and under the drive of drive arrangement (5), mechanical gripper (4) can make reagent box (B) shift between each installation site (2) or make reagent box (B) from exchange channel (1a) in and out reagent warehouse (1); Temporary loading and unloading module (A) includes base (6) fixedly assembled in reagent warehouse (1) top, and base (6) is equipped with taking and placing hole (6a) of making exchange channel (1a) expose, and each installation site (2) and exchange channel (1a) circular distribution are on the same circumference; Drive arrangement (5) includes crossbeam (5b), cantilever (5d) rotationally installed below crossbeam (5b) and rotation drive assembly (5c) for driving cantilever (5d) rotation, crossbeam (5b) is movably arranged above base (6) through lifting module (5a), the rotation center line of cantilever (5d) coincides with the circumferential center line of each installation site (2) circular distribution, and mechanical gripper (4) is arranged at the distal end of cantilever (5d); Each installation site (2) is provided in the form of clamping groove on base (6), including recovery buffer site (a), manual recovery site (b), manual placement site (c), first mixing site (d), second mixing site (e), magnetic attraction site (f) and temporary placement site (g), wherein the side of magnetic attraction site (f) is provided with fixed block (61), and the fixed block (61) is embedded with magnetic element (6b); Mixing assembly (3) includes two sets of shaking seats (3a) and mixing motor (3b) for driving two sets of shaking seats (3a) to rotate simultaneously, and two sets of shaking seats (3a) are rotationally installed below first mixing site (d) and second mixing site (e) one by one; Mechanical gripper (4) includes guide rail (4d) fixedly installed below the distal end of cantilever (5d), first clamping arm (4a) and second clamping arm (4b) slidably connected on guide rail (4d) and clamping motor (4c) for driving first clamping arm (4a) and second clamping arm (4b) to approach or move away from each other, first sensor (4e) and second sensor (4f) are fixedly installed at both ends of guide rail (4d) respectively, first clamping arm (4a) is provided with first light shield (4g) matched with first sensor (4e), second clamping arm (4b) is provided with second light shield (4h) matched with second sensor (4f), and the length of second light shield (4h) is greater than the length of first light shield (4g).

2. The temporarily mountable and demountable kit of reagents system according to claim 1, characterized in that: The base (6) is movably provided with a cover plate (7) in the taking and placing hole (6a), and the cover plate (7) is used for sealing the exchange channel (1a).

3. The temporarily mountable and demountable kit of reagents system according to claim 2, characterized in that: The inner end of the cover plate (7) is rotatably installed on the base (6) through a rotating shaft (7e), the center line of the rotating shaft (7e) coincides with the rotating center line of the cantilever (5d), the upper side of the cover plate (7) is provided with a first positioning block (7a) and a second positioning block (7b), and the lower side is provided with a limiting protrusion (7c) adapted to the exchange channel (1a), and the cover plate (7) can move up and down relative to the rotating shaft (7e); The first clamping arm (4a) and the second clamping arm (4b) can clamp the first positioning block (7a) and the second positioning block (7b), so that the limiting protrusion (7c) of the cover plate (7) is placed in the exchange channel (1a) or the limiting protrusion (7c) is taken out of the exchange channel (1a).

4. The temporarily mountable and demountable kit of reagents system according to claim 3, characterized in that: The rotating shaft (7e) is sleeved with a torsional spring (7d), and when the limiting protrusion (7c) is located in the exchange channel (1a), the torsional spring (7d) applies a force to the cover plate (7) to rotate it to one side.

5. The temporarily mountable and demountable kit of reagents system according to claim 4, characterized in that: The base (6) is provided with a third sensor (6c), and the height of the first positioning block (7a) exceeds the third sensor (6c), so that when the cover plate (7) is in the open position, the first positioning block (7a) can block the light sensing signal of the third sensor (6c).

6. The temporarily mountable and demountable kit of reagents system of claim 1, wherein: The reagent bin (1) comprises a bin body (11) and a bin cover (12), and the bin cover (12) is provided with a conventional placing hole (1b) and the exchange channel (1a).

Images