A combined device based on nuclear magnetic resonance and near infrared and a method thereof

Abstract

The application discloses a combined equipment based on nuclear magnetic resonance and near infrared and a method thereof, which comprises a nuclear magnetic resonance device, a near infrared device and a host computer. The nuclear magnetic resonance device comprises a probe assembly, and the near infrared device comprises an optical fiber probe. At least a part of the optical fiber probe is located in the probe assembly. The nuclear magnetic resonance device is used for collecting nuclear magnetic information of a to-be-detected article in the probe assembly. The near infrared device is used for collecting spectral information of the to-be-detected article in the probe assembly. The host computer is in communication connection with the nuclear magnetic resonance device and the near infrared device to control the nuclear magnetic resonance device and the near infrared device to collect the nuclear magnetic information and the spectral information of the to-be-detected article in the probe assembly and analyze components of the to-be-detected article based on the nuclear magnetic information and the spectral information. The combined equipment based on nuclear magnetic resonance and near infrared and the method thereof provided by the application realize simultaneous and in-situ collection of nuclear magnetic information and spectral information of a sample without interference.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of combined analytical instruments, in particular to a combined device based on nuclear magnetic resonance and near infrared and a method thereof. BACKGROUND

[0002] The near infrared spectrum analysis technology has good reproducibility. Due to the stability of spectrum measurement, the test result is less affected by the external environment, and compared with other test technologies, the near infrared spectrum analysis technology shows better reproducibility. However, the sensitivity of the near infrared spectrum analysis technology is low. Since the non-harmonic absorption transition probability of near infrared spectrum as molecular vibration is low, the intensity of the near infrared frequency doubling and frequency mixing band is generally one ten-thousandth of the fundamental frequency absorption, so for component analysis, the content is generally greater than 0.1% to adapt to the near infrared spectrum analysis technology.

[0003] The nuclear magnetic resonance analysis technology has high sensitivity, but the magnet of the nuclear magnetic resonance analyzer will change with the change of the environmental temperature, and the instability of the magnet field strength will lead to poor reproducibility of the measurement, in addition, the component analysis capability is weak.

[0004] In recent years, the nuclear magnetic resonance analysis technology combined with the near infrared spectrum analysis technology frequently appears in the fields of food agriculture, petroleum chemical industry, biological medicine, etc., including single instrument comparative analysis and fusion analysis of nuclear magnetic and near infrared data. Combining the two technologies can improve the sensitivity and reproducibility of sample testing, but in the existing technology, the sample is separated from one instrument to another instrument for sampling and detection. In the sampling and sampling process, the environmental temperature and humidity, personnel operation, sampling time and other factors will inevitably affect the sample, thereby causing deviation of the analysis result.

[0005] Therefore, it is necessary to develop a combined device based on nuclear magnetic resonance and near infrared and a method thereof, which becomes a technical problem to be solved by those skilled in the art. SUMMARY

[0006] The present application provides a combined device based on nuclear magnetic resonance and near infrared and a method thereof, which realizes simultaneous and in-situ acquisition of nuclear magnetic information and spectrum information of the sample without interference.

[0007] To solve one or more of the above technical problems, the technical scheme adopted by the present application is:

[0008] A combined device based on nuclear magnetic resonance and near infrared, comprising a nuclear magnetic resonance device, a near infrared device and an upper computer, the nuclear magnetic resonance device comprising a probe assembly, and the near infrared device comprising an optical fiber probe;

[0009] At least a part of the optical fiber probe is located in the probe assembly;

[0010] The nuclear magnetic resonance device is used to collect nuclear magnetic information of the to-be-detected article in the probe assembly;

[0011] The near-infrared device is used to collect spectral information of the to-be-detected article in the probe assembly;

[0012] The upper computer is in communication connection with the nuclear magnetic resonance device and the near-infrared device to control the nuclear magnetic resonance device and the near-infrared device to collect the nuclear magnetic information and the spectral information of the to-be-detected article in the probe assembly, and to analyze the components of the to-be-detected article based on the nuclear magnetic information and the spectral information.

[0013] Further, the nuclear magnetic resonance device comprises a magnet assembly, a pulse sequence generator, a frequency source, a radio frequency assembly, and an analog-to-digital converter.

[0014] The magnet assembly comprises a magnet and a magnet cabinet for placing the magnet, and the magnet is used to generate a magnetic field with a preset magnetic field strength to act on the to-be-detected article.

[0015] The pulse sequence generator is connected with the frequency source, and the pulse sequence generator cooperates with the frequency source to generate a radio frequency pulse signal.

[0016] The radio frequency assembly is connected with the pulse sequence generator and the frequency source, and the radio frequency assembly amplifies the radio frequency pulse signal to act on the probe assembly and amplifies the nuclear magnetic signal generated by the to-be-detected article in the probe assembly.

[0017] The analog-to-digital converter is connected with the radio frequency assembly, and the analog-to-digital converter is used to convert the amplified nuclear magnetic signal into a digital signal and transmit it to the upper computer to obtain the nuclear magnetic information.

[0018] Further, the near-infrared device further comprises a near-infrared spectrometer and a halogen light source, the near-infrared spectrometer and the halogen light source are outside the nuclear magnetic resonance device, one end of the optical fiber probe is connected with the near-infrared spectrometer and the halogen light source, and the other end of the optical fiber probe is located in the probe assembly.

[0019] Further, the number of optical fiber probes is two, the optical fiber probe comprises a first end, a second end, and an interface end, the first end is located in the probe assembly, the second end is located outside the probe assembly, and the interface end is used to connect the optical fiber probe with the halogen light source and the near-infrared spectrometer.

[0020] Further, the material of the first end comprises polytetrafluoroethylene, the material of the second end comprises plastic, and the interface end adopts SMA905 design.

[0021] Further, the probe assembly comprises a probe coil, two through holes are formed in the probe coil, the heights of the two through holes are equal, and two optical fiber probes enter the probe coil through the two through holes respectively, one of the optical fiber probes is used for applying light emitted by the halogen light source to the to-be-detected object, and the other optical fiber probe is used for receiving near-infrared light emitted by the to-be-detected object and transmitting the near-infrared light to the near-infrared spectrometer to obtain the spectral information of the to-be-detected object.

[0022] Further, the probe assembly further comprises interface knobs, the interface knobs are located on both sides of the probe coil and are equal in height to the through holes, the optical fiber probes pass through the interface knobs to enter the through holes, and a material of the interface knobs comprises polytetrafluoroethylene.

[0023] Further, the probe assembly further comprises a frame crossbeam, a fixing seat and a base knob.

[0024] The frame crossbeam is used for fixing the probe coil to avoid sliding of the probe coil in the magnet cabinet, the fixing seat surrounds the probe coil to fix the probe coil, and the base knob is arranged at the bottom of the probe coil to adjust the to-be-detected object in the probe coil to be in the middle of the two optical fiber probes.

[0025] Further, the upper computer comprises a human-computer interaction interface of the nuclear magnetic resonance device and the near-infrared device, the near-infrared device control software based on a Visual Studio 2019 platform and using a C# language is embedded into an interface of the nuclear magnetic resonance device sampling analysis software to realize real-time processing of the nuclear magnetic information and the spectral information.

[0026] The application further provides a method of a combined equipment based on nuclear magnetic resonance and near-infrared, the method comprising:

[0027] Placing a to-be-detected object into a probe coil, adjusting a position of the to-be-detected object through a base knob to ensure that the to-be-detected object is in the middle of two optical fiber probes;

[0028] Setting sampling parameters of a nuclear magnetic resonance device and a near-infrared device;

[0029] Controlling the nuclear magnetic resonance device and the near-infrared device to collect nuclear magnetic information and spectral information of the to-be-detected object through an upper computer;

[0030] Analyzing components of the to-be-detected object based on the nuclear magnetic information and the spectral information through the upper computer.

[0031] According to the specific embodiments provided in the application, the following technical effects are disclosed:

[0032] The application realizes the combined detection of the nuclear magnetic resonance device and the near-infrared device, realizes the simultaneous and same-site collection of the nuclear magnetic information and the spectrum information of the sample without interference, and solves the experimental error caused by sample transfer in the test process. Moreover, the combined device also makes up for the disadvantages of poor resolution and weak component analysis ability of a single instrument, and more abundant physical and chemical information of the detected object can be obtained by analyzing the nuclear magnetic information and the near-infrared spectrum information of the detected object.

[0033] Further, the material of the first end of the optical fiber probe in the probe assembly in the application is polytetrafluoroethylene, and since polytetrafluoroethylene does not contain hydrogen elements, the influence of the introduction of hydrogen elements on the test result can be avoided. In addition, the material of the second end of the optical fiber probe outside the probe assembly is plastic, and the use of plastic material can avoid the influence of the magnetic field strength, and ensure the accuracy of the nuclear magnetic measurement data. BRIEF DESCRIPTION OF DRAWINGS

[0034] In order to more clearly illustrate the technical solutions in the embodiments of the application or the prior art, the drawings needed to be used in the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative labor on the basis of these drawings.

[0035] Figure 1 The structure schematic diagram of the combined equipment based on nuclear magnetic resonance and near-infrared provided by the embodiment of the application is shown in the figure.

[0036] Figure 2 The connection schematic diagram of the probe assembly and the optical fiber probe in the nuclear magnetic resonance device provided by the embodiment of the application is shown in the figure.

[0037] Figure 3 The structure schematic diagram of the optical fiber probe provided by the embodiment of the application is shown in the figure. DETAILED DESCRIPTION

[0038] The technical solutions in the embodiments of the application will be described clearly and completely below. Obviously, the described embodiments are only some of the embodiments of the application, not all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art belong to the scope of protection of the application.

[0039] As described in the background, the combination of nuclear magnetic resonance analysis technology and near infrared spectrum analysis technology can improve the sensitivity and reproducibility of sample testing, but in the prior art, the sample is detected by sampling from one instrument to another instrument, and during sampling and sampling, environmental temperature and humidity, personnel operation, sampling time and other factors will inevitably affect the sample, thereby causing deviation of the analysis result. Therefore, the present application provides a combination device based on nuclear magnetic resonance and near infrared and a method thereof, which realizes simultaneous and in-situ acquisition of nuclear magnetic information and spectral information of the sample without interference, and solves the experimental error caused by sample transfer during testing. Moreover, through the combination of the nuclear magnetic resonance device and the near infrared device, the disadvantages of single instrument, such as poor resolution and weak component analysis ability, are overcome.

[0040] Figure 1 The structure schematic diagram of the combination device based on nuclear magnetic resonance and near infrared provided by the embodiment of the present application is shown in the figure. Figure 2 The connection schematic diagram of the probe assembly and the optical fiber probe in the nuclear magnetic resonance device provided by the embodiment of the present application is shown in the figure. Figure 3 The structure schematic diagram of the optical fiber probe provided by the embodiment of the present application is shown in the figure. Figure 1 As shown in the figure, with reference to Figure 2 and Figure 3 A combination device based on nuclear magnetic resonance and near infrared, comprising a nuclear magnetic resonance device, a near infrared device and a host computer 100, wherein the nuclear magnetic resonance device is used to acquire nuclear magnetic information of a to-be-detected article, the near infrared device is used to acquire spectral information of the to-be-detected article, the host computer 100 is in communication connection with the nuclear magnetic resonance device and the near infrared device to control the nuclear magnetic resonance device and the near infrared device to acquire the nuclear magnetic information and the spectral information of the to-be-detected article, and to analyze the components of the to-be-detected article based on the nuclear magnetic information and the spectral information. Further, the host computer 100 comprises a human-computer interaction interface of the nuclear magnetic resonance device and the near infrared device, a near infrared device control software based on Visual Studio 2019 platform using C# language is embedded into the nuclear magnetic resonance device sampling analysis software interface, and real-time processing of the nuclear magnetic information and the spectral information is realized.

[0041] The nuclear magnetic resonance device comprises a pulse sequence generator 110, a frequency source 200, an analog-to-digital converter 300, a radio frequency assembly 400, a magnet assembly 500, and a probe assembly, wherein the radio frequency assembly 400 comprises a radio frequency amplifier 410, a radio frequency switch 420, a preamplifier 430, and a radio frequency cabinet 440; the magnet assembly 500 comprises a magnet 510 and a magnet cabinet 520; the probe assembly comprises a probe coil 610, a frame crossbeam 620, a fixing seat 630, a base knob 640, an interface knob 650, a through hole (not shown in the figure), and the probe coil 610 comprises a sample cell 611 and a radio frequency coil 612. The near-infrared device comprises a near-infrared spectrometer 700, a halogen light source 800, and an optical fiber probe 900, at least a part of the optical fiber probe 900 is located in the probe assembly, wherein the optical fiber probe 900 comprises a first end 910, a second end 920, and an interface end 930.

[0042] The upper computer 100 sends a signal to make the pulse sequence generator 110 and the frequency source 200 generate a radio frequency pulse signal with a required frequency and shape, the radio frequency pulse signal is amplified by the radio frequency amplifier 410, the amplified radio frequency pulse signal is loaded onto the radio frequency coil 612 of the probe coil 610 through the radio frequency switch 420 to excite the sample cell 611 to generate a nuclear magnetic signal, the radio frequency coil 612 simultaneously receives the nuclear magnetic signal generated in the attenuation process of the sample, the nuclear magnetic signal is amplified by the preamplifier 430, the amplified nuclear magnetic signal is converted into a digital signal by the analog-to-digital converter 300, and the digital signal is transmitted to the upper computer 100 to obtain nuclear magnetic information of the sample, wherein the nuclear magnetic information comprises an attenuation signal of nuclear magnetic resonance of the sample.

[0043] The magnet assembly 500 comprises the magnet 510 and the magnet cabinet 520 in which the magnet 510 is placed, and the magnet 510 is used to generate a magnetic field with a preset magnetic field strength to act on the sample, in the embodiment of the application, the material of the magnet 510 is mainly a rare earth material such as a rare earth material of rubidium iron boron. The atomic nucleus of the sample is equivalent to a small magnet, the spin axis distribution and arrangement of the small magnet are chaotic, the sample is placed in the magnetic field generated by the magnet 510, the small magnets are regularly arranged according to the direction of the magnetic field, and then a radio frequency pulse affecting the magnetic field is applied, the atomic nucleus absorbs energy and jumps to a high energy state, and the signal released after the atomic nucleus returns to the initial state after the radio frequency pulse is ended is the nuclear magnetic signal.

[0044] The near-infrared spectrometer 700 in the near-infrared device is connected with the upper computer 100, the halogen light source 800 emits light to the sample in the sample cell 611 through one end of the optical fiber probe 900, the light is transmitted to the near-infrared spectrometer 700 from the other end of the optical fiber probe 900 after passing through the sample, and the upper computer 100 obtains spectral information of the sample through the near-infrared spectrometer 700.

[0045] In one embodiment, the number of optical fiber probes 900 is two, one of which is connected to the halogen light source 800 at one end and is located in the probe coil 610 at the other end, and the light emitted by the halogen light source 800 is transmitted through the optical fiber probe 900 and penetrates the object to be detected. The other optical fiber probe 900 is located in the probe coil 610 at one end and is connected to the near-infrared spectrometer 700 at the other end, and the light transmitted through the object to be detected is transmitted from the other end of the optical fiber probe 900 to the near-infrared spectrometer 700, and the host computer 100 obtains the spectral information of the object to be detected through the near-infrared spectrometer 700.

[0046] The optical fiber probe 900 includes a first end 910, a second end 920, and an interface end 930, the first end 910 is located in the probe assembly, the second end 920 is located outside the probe assembly, and the interface end 930 is used to connect the optical fiber probe 900 with the halogen light source 800 and the near-infrared spectrometer 700. Since the nuclear magnetic resonance device relies on detecting the hydrogen atom signal in the sample to obtain nuclear magnetic information, in order to avoid the introduction of hydrogen element interference, the material of the first end 910 of the optical fiber probe 900 located in the probe assembly is preferably polytetrafluoroethylene. In addition, the material of the second end 920 of the optical fiber probe 900 located outside the probe assembly is plastic, which can avoid affecting the magnetic field strength and ensure the accuracy of the nuclear magnetic measurement data. The interface end 930 is designed with SMA905, which can improve the micro-bending resistance of the optical fiber probe 900, improve the high-temperature resistance of the optical fiber probe 900, and reduce the micro-bending additional loss of the optical fiber probe 900.

[0047] In one embodiment, the optical fiber probe 900 is made of quartz optical fiber with a core diameter of 600 / 660 μm, and the total length is 900 mm, wherein the inner core diameter of the optical fiber probe 900 is 600 μm, and the outer core diameter of the optical fiber probe 900 is 660 μm. The length of the first end 910 located in the probe assembly is 50 mm, and the length of the second end 920 located outside the probe assembly is 850 mm.

[0048] In another specific embodiment, two through holes (not shown) are formed on the probe coil 610, the two through holes (not shown) have the same height, and the two optical fiber probes 900 enter the probe coil 610 through the two through holes (not shown) respectively. In order to fix the optical fiber probes 900, interface knobs 650 are arranged on both sides of the probe coil 610 and have the same height as the through holes (not shown), the optical fiber probes 900 pass through the interface knobs 650 to enter the through holes (not shown), and the interface knobs 650 can ensure that the optical fiber probes 900 entering the through holes can be fixed horizontally at both ends of the probe coil 610. In order to avoid the interference of the introduction of hydrogen elements, the material of the interface knobs 650 is preferably polytetrafluoroethylene.

[0049] In one specific embodiment, a copper band is wound around the outer periphery of the probe coil 610, the width of the copper band is 6 mm, the copper band is wound around the outer periphery of the probe coil 610 for 8 turns, two through holes (not shown) are formed at the horizontal positions of the second turn and the third turn away from the bottom of the probe coil 610, and the diameter of the through holes is 8 mm.

[0050] In another specific embodiment, a base knob 640 is arranged at the bottom of the probe coil 610, the base knob 640 is used to adjust the position of the object to be detected in the probe coil 610 to be in the middle of the two optical fiber probes 900. A frame crossbeam 620 is further arranged at the upper part of the probe coil 610, the frame crossbeam 620 is used to fix the probe coil 610 to avoid the probe coil 610 from sliding in the magnet cabinet 520. In addition, a fixing seat 630 is further arranged around the probe coil 610, and the fixing seat 630 is used to further fix the probe coil 610.

[0051] The application also provides a method based on a combination of nuclear magnetic resonance and near-infrared equipment, the method comprising:

[0052] S1: placing an object to be detected into a probe coil, adjusting the position of the object to be detected by a base knob to ensure that the object to be detected is in the middle of two optical fiber probes.

[0053] S2: setting the sampling parameters of the nuclear magnetic resonance device and the near-infrared device.

[0054] Specifically, the nuclear magnetic resonance device is controlled by a host computer, the nuclear magnetic radio frequency pulse frequency is adjusted to be consistent with the magnet frequency, the parameters such as the hard pulse width are determined, and the integral time and the number of scans of the near-infrared spectrometer are set according to the spectral energy of the halogen light source.

[0055] S3: collecting the nuclear magnetic information and the spectral information of the object to be detected by the nuclear magnetic resonance device and the near-infrared device controlled by the host computer.

[0056] Specifically, the nuclear magnetic information comprises a nuclear magnetic relaxation signal.

[0057] S4: The host computer analyzes the components of the to-be-detected article based on the nuclear magnetic information and the spectrum information.

[0058] Specifically, a prediction model is established based on the collected sample nuclear magnetic data and spectrum data offline, the prediction model is imported into the host computer, and the nuclear magnetic information and spectrum information of the to-be-detected article obtained through detection are brought into the prediction model to obtain the physicochemical value index information of the to-be-detected article.

[0059] Further, the prediction model is an analysis model established by using chemometrics according to the relationship between nuclear magnetic or spectrum data and attribute values of the to-be-detected article. The model needs to be established separately for different sample types. If an out-of-model sample is encountered, the model needs to be expanded and maintained according to the composition and properties of the to-be-detected sample.

[0060] The method based on the combined device of nuclear magnetic resonance and near infrared provided in the application is described in detail above, and specific examples are applied to describe the principle and implementation mode of the application. The above description of the embodiments is only used to help understand the method and its core idea of the application. Meanwhile, for those skilled in the art, according to the idea of the application, the specific implementation mode and application range can be changed. In summary, the content of the specification should not be understood as a limitation of the application.

[0061] In the description of the present application, it should be understood that the orientations or positional relationships indicated by the terms "vertical", "parallel", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation of the present application. In addition, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first", "second" can explicitly or implicitly include one or more features. In the description of the present application, unless otherwise specified, the meaning of "a plurality of" is two or more.

[0062] In the description of the application, it is necessary to explain that, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through intermediate medium, or the communication inside two elements. For ordinary skilled in the art, the specific meaning of the above terms in the application can be understood according to the specific circumstances.

[0063] The above is only the preferred embodiment of the present application, and is not used to limit the present application, any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A device based on the combined use of nuclear magnetic resonance and near-infrared spectroscopy, characterized in that, It includes a nuclear magnetic resonance device, a near-infrared device, and a host computer. The nuclear magnetic resonance device includes a probe assembly, and the near-infrared device includes a fiber optic probe. At least a portion of the fiber optic probe is located within the probe assembly; The nuclear magnetic resonance device is used to collect the nuclear magnetic information of the item to be tested in the probe assembly; The near-infrared device is used to collect the spectral information of the item to be detected in the probe assembly; The host computer is communicatively connected to the nuclear magnetic resonance device and the near-infrared device to control the nuclear magnetic resonance device and the near-infrared device to acquire the nuclear magnetic information and the spectral information of the item to be tested in the probe assembly, and to analyze the composition of the item to be tested based on the nuclear magnetic information and the spectral information; The nuclear magnetic resonance device includes a magnet assembly, a pulse sequence generator, a frequency source, a radio frequency assembly, and an analog-to-digital converter; The magnet assembly includes a magnet and a magnet cabinet for placing the magnet. The magnet is used to generate a magnetic field of a preset magnetic field strength to act on the item to be tested. The pulse sequence generator is connected to the frequency source, and the pulse sequence generator cooperates with the frequency source to generate radio frequency pulse signals; The radio frequency component is connected to the pulse sequence generator and the frequency source. The radio frequency component amplifies the radio frequency pulse signal to act on the probe assembly and amplifies the nuclear magnetic resonance signal generated by the item to be detected in the probe assembly. The analog-to-digital converter is connected to the radio frequency component. The analog-to-digital converter is used to convert the amplified NMR signal into a digital signal and transmit it to the host computer to obtain the NMR information. The near-infrared device also includes a near-infrared spectrometer and a halogen light source. The near-infrared spectrometer and the halogen light source are located outside the nuclear magnetic resonance device. One end of the fiber optic probe is connected to the near-infrared spectrometer and the halogen light source, and the other end of the fiber optic probe is located in the probe assembly. The optical fiber probes are of two types, each including a first end, a second end, and an interface end. The first end is located inside the probe assembly, the second end is located outside the probe assembly, and the interface end is used to connect the optical fiber probes to the halogen light source and the near-infrared spectrometer.

2. The device based on the combined nuclear magnetic resonance and near-infrared spectroscopy according to claim 1, characterized in that, The first end is made of polytetrafluoroethylene, the second end is made of plastic, and the interface end adopts the SMA905 design.

3. The device based on the combined nuclear magnetic resonance and near-infrared spectroscopy according to claim 1, characterized in that, The probe assembly includes a probe coil with two through holes of equal height. Two fiber optic probes enter the probe coil through the two through holes. One fiber optic probe is used to apply the light emitted by the halogen light source to the item to be tested, and the other fiber optic probe is used to receive the near-infrared light emitted by the item to be tested and transmit it to the near-infrared spectrometer to obtain the spectral information of the item to be tested.

4. The device based on the combined nuclear magnetic resonance and near-infrared spectroscopy according to claim 3, characterized in that, The probe assembly also includes an interface knob located on both sides of the probe coil and at the same height as the through hole. The fiber optic probe passes through the interface knob to enter the through hole. The interface knob is made of polytetrafluoroethylene.

5. The device based on the combined nuclear magnetic resonance and near-infrared spectroscopy according to claim 4, characterized in that, The probe assembly also includes a frame beam, a mounting base, and a base knob; The frame beam is used to fix the probe coil to prevent the probe coil from sliding in the magnet cabinet. The fixing base is wrapped around the probe coil to fix the probe coil. The base knob is located at the bottom of the probe coil to adjust the position of the object to be detected in the probe coil between the two fiber optic probes.

6. The combined nuclear magnetic resonance and near-infrared spectroscopy device according to claim 1, characterized in that, The host computer includes a human-machine interface for the nuclear magnetic resonance device and the near-infrared device. The near-infrared device control software, written in C# using the Visual Studio 2019 platform, is embedded in the nuclear magnetic resonance device sampling and analysis software interface to realize real-time processing of the nuclear magnetic resonance information and the spectral information.

7. A method for a combined nuclear magnetic resonance (NMR) and near-infrared (NIIR) device, applied in the combined NMR and NIIR device according to any one of claims 1 to 6, characterized in that, The method includes: Place the item to be tested into the probe coil, and adjust the position of the item to be tested using the base knob to ensure that the item to be tested is in the middle of the two fiber optic probes; Set the sampling parameters for the nuclear magnetic resonance (NMR) and near-infrared (NII) devices; The nuclear magnetic resonance device and the near-infrared device are controlled by a host computer to collect the nuclear magnetic resonance information and spectral information of the item to be tested; The host computer analyzes the composition of the item to be detected based on the nuclear magnetic resonance information and the spectral information.

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