A flexible and highly sensitive array sensor for pulse diagnosis

Abstract

The present invention provides a flexible and highly sensitive array sensor for pulse diagnosis detection, comprising: a bottom flexible substrate; a plurality of flexible coplanar serpentine interdigital electrodes, arranged on the bottom flexible substrate; an adhesive packaging layer, arranged at the edge of the bottom flexible substrate, coplanar with the plurality of flexible coplanar serpentine interdigital electrodes; a plurality of sensitive layers with micro-column structures, arranged on the plurality of flexible coplanar serpentine interdigital electrodes; a microporous spacer layer, arranged on the plurality of sensitive layers with micro-column structures; and a surface packaging layer, arranged on the microporous spacer layer. The above-mentioned sensor, the flexible pressure sensing array, can conformally fit with the human body surface, and can monitor the patient's pulse information more friendly. By arranging the array sensor near the pulse point, the defect of position sliding of the single-point sensor during the detection process can be avoided, and more comprehensive pulse diagnosis information can be obtained.

Description

Technical Field

[0001] The invention relates to a method for preparing a large-scale flexible pressure sensor for human health and motion detection, and belongs to the frontier cross-manufacturing technical field of flexible electronics and pressure sensors. Background Art

[0002] The digitization and objectification of TCM diagnosis is one of the problems that need to be solved in the modernization of TCM. Pulse diagnosis is one of the most distinctive ways of diagnosing diseases in TCM, and it is of great significance to digitize the pulse diagnosis process using sensor technology.

[0003] Currently, most of the existing pulse wave sensors are single-point rigid probes with large probe area and low spatial resolution. It is difficult to perform multi-channel pulse detection in a small area at the same time. It is impossible to accurately simulate the traditional Chinese medicine to accurately extract the pulse width and pulse length elements. The information obtained is limited, and therefore it is impossible to achieve the effect of accurate pulse diagnosis in imitation of traditional Chinese medicine. The emergence of flexible pressure sensor arrays is expected to become an important means to solve this problem. Flexible pressure sensor arrays can conformally fit with the human body surface and can monitor the patient's pulse information more friendly. By arranging array sensors near the pulse point, the defect of single-point sensors sliding during the detection process can be avoided, and more comprehensive pulse diagnosis information can be obtained. Summary of the invention

[0004] In order to solve the above defects existing in the prior art, the purpose of the present invention is to solve the existing functional requirements and technical deficiencies, and to propose a flexible and highly sensitive array sensor for pulse diagnosis detection.

[0005] In order to solve the above technical problems, the present invention provides a flexible and highly sensitive array sensor for pulse diagnosis detection, comprising:

[0006] a bottom flexible substrate;

[0007] A plurality of flexible coplanar serpentine interdigitated electrodes are disposed on the bottom flexible substrate;

[0008] An adhesive packaging layer is disposed at the edge of the bottom flexible substrate and is coplanar with the plurality of flexible coplanar serpentine interdigitated electrodes;

[0009] A plurality of sensitive layers with micro-pillar structures are arranged on the plurality of flexible coplanar serpentine interdigital electrodes;

[0010] A microporous spacer layer is disposed on the plurality of sensitive layers having microcolumn structures;

[0011] A surface encapsulation layer, disposed on the microporous spacer layer;

[0012] In a preferred embodiment: the bottom flexible substrate, multiple flexible coplanar serpentine interdigitated electrodes, adhesive packaging layer, multiple sensitive layers with micro-column structures, microporous spacer layer, and surface packaging layer constitute a pulse length and width detection patch for traditional Chinese medicine pulse diagnosis based on array sensing mechanism.

[0013] In a preferred embodiment: it also includes a ring-shaped airbag, which is arranged on the pulse length and width detection patch of traditional Chinese medicine pulse diagnosis based on the array sensing mechanism.

[0014] In a preferred embodiment: it also includes an airbag pressure applying device, which is connected to the annular airbag through an inflation interface and controls the internal pressure of the airbag through an electric device.

[0015] In a preferred embodiment: it also includes a pulse detection device, which includes a processor, a communication circuit and a signal acquisition circuit, which collects the output signal of the pulse length and pulse width detection patch of traditional Chinese medicine pulse diagnosis based on the array sensing mechanism, and transmits it wirelessly after preprocessing.

[0016] In a preferred embodiment: the pulse detection device includes a multi-channel capacitance acquisition module, which is arranged on a flexible substrate, obtains signals by row and column scanning, and is connected to a PC and a mobile phone by wireless transmission.

[0017] In a preferred embodiment: the bottom flexible substrate includes one of a variety of polymers such as thermoplastic polyurethane (TPU), polyolefin elastomer, polystyrene elastomer, polyamide elastomer, silicone rubber, styrene block copolymer, and fiber materials such as paper, leather, and cloth.

[0018] In a preferred embodiment, the area of ​​a single electrode in the plurality of flexible coplanar serpentine interdigitated electrodes is 0.3 mm 2 ~4mm 2 , the distance between two adjacent flexible electrodes is 0.1mm~0.2mm;

[0019] The area occupied by the multiple flexible coplanar serpentine interdigitated electrodes is 0.5 cm 2 ~20cm 2 ;

[0020] The plurality of flexible coplanar serpentine interdigitated electrodes are rectangular.

[0021] In a preferred embodiment: the doping material of the multiple sensitive layers with micro-column structures includes at least one of metal materials, carbon materials, and conductive polymers.

[0022] In a preferred embodiment: the surface encapsulation layer is encapsulated by a PI film.

[0023] Compared with the prior art, the technical solution of the present invention has the following beneficial effects:

[0024] The present invention provides a flexible and highly sensitive array sensor for pulse diagnosis detection. The flexible pressure sensing array can conform to the human body surface and can monitor the patient's pulse information more friendly. By arranging the array sensor near the pulse point, the defect of position slippage of the single point sensor during the detection process can be avoided, and more comprehensive pulse diagnosis information can be obtained. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 A hierarchical schematic diagram of a preferred embodiment of the present invention;

[0026] Figure 2 This is a measurement module diagram of a preferred embodiment of the present invention. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention; it is obvious that the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments, and all other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making creative work are within the scope of protection of the present invention.

[0028] In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top / bottom" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0029] In the description of the present invention, it should be noted that, unless otherwise clearly stipulated and limited, the terms "installed", "provided with", "mounted / connected", "connected", etc. should be understood in a broad sense. For example, "connection" can be a wall-mounted connection, a detachable connection, or an integral connection. It can be a mechanical connection or an electrical connection. It can be a direct connection or an indirect connection through an intermediate medium. It can be the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0030] Example 1

[0031] like Figure 1-2As shown, a flexible high-sensitivity array sensor for pulse diagnosis detection provided in this embodiment includes a pulse length and width detection patch for Chinese medicine pulse diagnosis based on an array sensing mechanism, a ring-shaped airbag, an airbag pressure device and a pulse condition detection device. One of the pulse length and width detection patches for Chinese medicine pulse diagnosis based on an array sensing mechanism includes a flexible substrate 1, an adhesive packaging layer 3, a plurality of sensitive layers 4 with micro-column structures, a microporous spacer layer 5, and a surface packaging layer 6. The plurality of flexible coplanar serpentine interdigital electrodes 2, including a plurality of separate flexible coplanar serpentine interdigital electrodes 2, are arranged on the bottom flexible substrate 1. The adhesive packaging layer 3 is arranged at the edge of the bottom flexible substrate 1 and is coplanar with the plurality of flexible coplanar serpentine interdigital electrodes 2; the plurality of sensitive layers 4 with micro-column structures are arranged on the plurality of flexible coplanar serpentine interdigital electrodes 2. The microporous spacer layer 5 is arranged on the plurality of sensitive layers 4 with micro-column structures. The surface packaging layer 6 is arranged on the microporous spacer layer 5.

[0032] The bottom flexible substrate 1 includes one of various polymers such as thermoplastic polyurethane (TPU), polyolefin elastomer, polystyrene elastomer, polyamide elastomer, silicone rubber, styrene block copolymer, and fiber materials such as paper, leather, and cloth.

[0033] The raw materials of the multiple sensitive layers 4 with micro-column structures are a composite of at least one of metal materials (such as liquid metal, metal particles, and metal nanowires), carbon materials (such as carbon black (CB), carbon nanotubes (CNTs), and graphene), conductive polymers (such as poly (3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS)) and other materials (such as MOF, MXene) and a polymer elastomer (for example: the bottom flexible substrate 1 includes one of a variety of polymers such as thermoplastic polyurethane (TPU), polyolefin elastomer, polystyrene elastomer, polyamide elastomer, silicone rubber, styrene block copolymer, etc.).

[0034] The modification and doping of the multiple sensitive layers 4 with micro-column structures mainly includes three steps: sensitive ink preparation, screen printing (or spin coating) and laser etching.

[0035] The bonding packaging layer 3 is a double-sided adhesive tape.

[0036] The area of ​​a single electrode in the plurality of flexible coplanar serpentine interdigitated electrodes 2 is 0.3 mm 2 ~4mm 2 The distance between two adjacent flexible electrodes is 0.1 mm to 0.2 mm.

[0037] The plurality of flexible coplanar serpentine interdigital electrodes 2 are rectangular.

[0038] The area occupied by the multiple flexible coplanar serpentine interdigital electrodes 2 is 0.5 cm 2 ~20cm 2 .

[0039] The plurality of sensitive layers 4 with micro-column structures can be spatially aligned with the via holes of the spacing layer, thereby ensuring that no slip occurs between the electrode and the sensitive layer 4 during the bending deformation process.

[0040] The annular airbag is arranged on the pulse length and width detection patch of traditional Chinese medicine pulse diagnosis based on array sensing mechanism and is covered by the airbag.

[0041] The airbag pressure applying device is connected to the annular airbag via an inflation interface, and the internal pressure of the airbag can be controlled by an electric device.

[0042] The pulse condition detection device comprises a processor, a communication circuit and a signal acquisition circuit, which collects the output signal of the pulse length and width detection patch of traditional Chinese medicine pulse diagnosis based on the array sensing mechanism, performs preprocessing, and wirelessly transmits it.

[0043] The pulse detection device includes a multi-channel capacitance acquisition module, which is arranged on a flexible substrate, obtains signals by row and column scanning, and can be connected to a PC and a mobile phone by wireless transmission.

[0044] In this embodiment, two-dimensional nanomaterial boron nitride is selected as a doping material to prepare multiple sensitive layers 4 with micro-column structures. Specifically, the prepared h-BN ionic liquid is added to the prepared TPU solution. The flexible ion membrane is prepared by screen printing. Finally, the sensitive layer 4 with micro-column structure is prepared by laser etching technology.

[0045] In this embodiment, PI material is selected to prepare the microporous spacer layer 5. Specifically, the prepared PI precursor is spin-coated, and the hole structure is etched by laser to ensure that the electrode can be exposed through the micropores.

[0046] In this embodiment, the preparation of multiple flexible coplanar serpentine interdigitated electrodes 2 is specifically as follows: first, the bottom flexible substrate 1 is plasma treated, then, a metal copper film is screen-printed on the bottom flexible substrate 1, and finally, laser etching technology is used to complete the preparation of the multiple flexible coplanar serpentine interdigitated electrodes 2.

[0047] In this embodiment, a pulse length and pulse width testing method based on a high-precision pressure array sensor is provided.

[0048] In this embodiment, a flexible sensor array is designed to meet the needs of pulse width and pulse length detection. The designed sensor array is shown in the figure. The arrangement is denser perpendicular to the blood vessel direction, and sparser along the blood vessel direction.

[0049] In this embodiment, an annular airbag is used for pressurization, and the airbag pressure is controlled in the range of 0 to 300 mmHg.

[0050] In another aspect of the present invention, a pulse detection system is provided, which comprises the flexible pressure sensor and a processor according to any one of the above embodiments.

[0051] The processor is used to receive the digital signal sent by the analog-to-digital converter and convert it into a real-time one-dimensional waveform diagram and a dynamic three-dimensional pulse diagram, and then output the pulse length and pulse width in traditional Chinese medicine pulse diagnosis.

[0052] The above is only a preferred specific implementation of the present invention, but the design concept of the present invention is not limited to this. Any technician familiar with the technical field who uses this concept to make non-substantial changes to the present invention within the technical scope disclosed by the present invention shall be deemed to infringe the protection scope of the present invention.

Claims

1. A flexible and highly sensitive array sensor for pulse diagnosis, characterized in that include: a bottom flexible substrate; A plurality of flexible coplanar serpentine interdigitated electrodes are disposed on the bottom flexible substrate; An adhesive packaging layer is disposed at the edge of the bottom flexible substrate and is coplanar with the plurality of flexible coplanar serpentine interdigitated electrodes; A plurality of sensitive layers with micro-pillar structures are arranged on the plurality of flexible coplanar serpentine interdigital electrodes; A microporous spacer layer is disposed on the plurality of sensitive layers having microcolumn structures; The surface encapsulation layer is arranged on the microporous spacer layer.

2. The flexible and highly sensitive array sensor for pulse diagnosis detection according to claim 1, characterized in that: The bottom flexible substrate, multiple flexible coplanar serpentine interdigital electrodes, adhesive packaging layer, multiple sensitive layers with micro-column structures, microporous spacing layer, and surface packaging layer constitute a pulse length and width detection patch for traditional Chinese medicine pulse diagnosis based on an array sensing mechanism.

3. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 2, characterized in that: It also includes an annular air bag, which is arranged on the pulse length and width detection patch of traditional Chinese medicine pulse diagnosis based on the array sensing mechanism.

4. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 3, characterized in that: It also includes an airbag pressure device, which is connected to the annular airbag through an inflation interface and controls the internal pressure of the airbag through an electric device.

5. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 4, characterized in that: It also includes a pulse detection device, which includes a processor, a communication circuit and a signal acquisition circuit, which collects the output signal of the pulse length and width detection patch of traditional Chinese medicine pulse diagnosis based on the array sensing mechanism, and transmits it wirelessly after preprocessing.

6. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 5, characterized in that: The pulse detection device includes a multi-channel capacitance acquisition module, which is arranged on a flexible substrate, obtains signals through a row and column scanning method, and is connected to a PC and a mobile phone through wireless transmission.

7. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 1, characterized in that: The bottom flexible substrate comprises one of thermoplastic polyurethane (TPU), polyolefin elastomer, polystyrene elastomer, polyamide elastomer, silicone rubber, styrene block copolymer, paper, leather and cloth.

8. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 1, characterized in that: The area of ​​a single electrode in the plurality of flexible coplanar serpentine interdigitated electrodes is 0.3 mm 2 ~4mm 2 , the distance between two adjacent flexible electrodes is 0.1mm~0.2mm; The area occupied by the multiple flexible coplanar serpentine interdigitated electrodes is 0.5 cm 2 ~20cm 2 ; The plurality of flexible coplanar serpentine interdigitated electrodes are rectangular.

9. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 1, characterized in that: The doping material of the plurality of sensitive layers having micro-column structures includes at least one of metal materials, carbon materials and conductive polymers.

10. The flexible high-sensitivity array sensor for pulse diagnosis detection according to claim 1, characterized in that: The surface encapsulation layer is encapsulated by a PI film.

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