An antioxidant whitening composition and its preparation method and application

Abstract

The present invention belongs to the field of cosmetic technology, and specifically relates to an antioxidant whitening composition, its preparation method, and application. Every 100 parts of the antioxidant whitening composition include the following components in parts by weight: 0.1-5.0 parts of saccharide isomers, 0.2-2.5 parts of tranexamic acid, 0.5-10 parts of Chondrus crispus extract, 0.2-2.5 parts of tea extract, 1.0-4.0 parts of yeast extract, 0.2-3.0 parts of plant whitening agent, 0.2-0.8 parts of thickener, 0.2-5.0 parts of anti-allergic agent, 0.2-0.5 parts of preservative, and the balance of water. The antioxidant whitening composition of the present invention can solve the shortcomings of the existing technology in terms of single antioxidant and whitening properties, has excellent antioxidant and whitening effects, is non-irritating, and is suitable for people with different skin types.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to an antioxidant whitening composition, a preparation method and an application thereof. Background Art

[0002] Skin color is determined by a complex interplay of various factors, including the skin's physiological surface conditions, blood flow, moisture, and pigmentation. Among these factors, melanin is the most crucial. Excessive melanin synthesis can cause hyperpigmented skin conditions such as freckles, chloasma, age spots, and melanoma. Modern research indicates that melanin is a high-molecular-weight polymer bound to proteins and indoles and quinones. Its synthesis is a stress response of melanocytes in the basal layer of the epidermis. Excessive melanin synthesis can cause hyperpigmented skin conditions such as freckles, chloasma, and age spots. Studies have shown that tyrosinase is the rate-limiting enzyme in melanin biosynthesis. It hydroxylates tyrosine, the primary raw material for melanin production, to produce L-dopa, which is then oxidized to dopaquinone. Dopaquinone then undergoes a series of metabolic processes, rearranges and polymerizes, ultimately binding to proteins to form a series of melanopsins, which are responsible for browning. During this process, the oxidative stress generated by free radicals also promotes melanin production in melanocytes by activating a series of cellular pathways, including tyrosinase (Tyr), human tyrosinase-related proteins (TRP1 and TRP2), and microphthalmia-related transcription factor (MITF). Therefore, antioxidant and inhibition of the expression of related proteins can provide effective whitening effects. However, the antioxidant and whitening ingredients in the antioxidant and whitening compositions of the prior art are relatively simple, with weak antioxidant and whitening effects. In addition, commercially available antioxidant and whitening products also have problems such as low absorption efficiency, resulting in insignificant effects. Summary of the Invention

[0003] The present invention aims to provide an antioxidant whitening composition, its preparation method, and its application. This antioxidant whitening composition can address the shortcomings of existing technologies, which only provide single antioxidant and whitening properties. It has excellent antioxidant and whitening effects, is non-irritating, and is suitable for people with different skin types.

[0004] In order to achieve the above-mentioned object, the present invention adopts the following technical scheme: an antioxidant whitening composition, wherein every 100 parts of the antioxidant whitening composition comprises the following components in parts by weight: 0.1-5.0 parts of carbohydrate isomers, 0.2-2.5 parts of tranexamic acid, 0.5-10 parts of crispy chondrus crispus extract, 0.2-2.5 parts of tea extract, 1.0-4.0 parts of yeast extract, 0.2-3.0 parts of plant whitening agent, 0.2-0.8 parts of thickener, 0.2-5.0 parts of antiallergic agent, 0.2-0.5 parts of preservative, and the balance of water.

[0005] Preferably, every 100 parts of the antioxidant whitening composition comprises the following components in parts by weight: 0.2-1.0 parts of carbohydrate isomers, 0.8-1.5 parts of tranexamic acid, 1.0-5.0 parts of crispy chondrus crispus extract, 1.0-2.0 parts of tea extract, 2.0-3.0 parts of yeast extract, 0.5-2.0 parts of plant whitening agent, 0.3-0.6 parts of thickener, 0.3-2.0 parts of anti-allergic agent, 0.3-0.4 parts of preservative, and the balance of water.

[0006] Preferably, every 100 parts of the antioxidant whitening composition comprises the following components in parts by weight: 0.5 parts of carbohydrate isomers, 1.0 parts of tranexamic acid, 1.5 parts of Chondrus crispus extract, 1.5 parts of tea extract, 2.5 parts of yeast extract, 1.0 parts of plant whitening agent, 0.5 parts of thickener, 0.5 parts of anti-allergic agent, 0.4 parts of preservative, and the balance of water.

[0007] Preferably, the antioxidant whitening composition comprises at least one of the following (1) and (2):

[0008] (1) The plant whitening agent is safflower seed oil, bisabolol, and tocopherol;

[0009] (2) The anti-allergic agent is one or more of Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, Glycyrrhiza glabra root extract, Chamomile flower extract, and Rosemary leaf extract.

[0010] Preferably, the antioxidant whitening composition comprises at least one of the following (1) and (2):

[0011] (1) The thickener is hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer;

[0012] (2) The preservative is at least one of propylene glycol, caprylhydroxamic acid, and glyceryl caprylate.

[0013] The present invention also provides a method for preparing the antioxidant whitening composition, comprising the following steps:

[0014] S1. Add the formulated amount of carbohydrate isomers, tranexamic acid, and water in sequence, heat, and stir evenly to obtain a mixed solution A;

[0015] S2. Add the formulated amount of thickener and plant whitening agent to the mixed solution A obtained in step S1, disperse evenly, homogenize, and keep warm to obtain mixed solution B;

[0016] S3. Stir and cool the mixed solution B obtained in step S2 to below 75° C., add the formulated amount of preservatives, stir evenly, keep warm, cool to 30-40° C., add the formulated amount of anti-allergic agent, Chondrus crispus extract, tea extract, and yeast extract, and stir evenly to obtain an antioxidant whitening composition.

[0017] Preferably, the heating in step S1 is to be heated to 82-85°C.

[0018] Preferably, the homogenization speed in step S2 is 2500-3000 rpm, and the homogenization time is 5-8 minutes.

[0019] Preferably, the insulation time in step S2 is 5 to 7 minutes; and the insulation time in step S3 is 9 to 12 minutes.

[0020] The present invention also provides an application of the antioxidant whitening composition in the preparation of cosmetics.

[0021] The carbohydrate isomers in the present invention provide moisturizing, making the skin appear hydrated and plump; tranexamic acid can inhibit the activity of inflammatory proteases and simultaneously cut off the formation pathway of melanin; tea (CAMELLIA SINENSIS) leaf extract has strong antioxidant emergency protection and broad-spectrum protection, protecting proteins from damage, inhibiting tyrosinase activity and melanin formation, regulating PLA2 activity and inhibiting cytokine production; yeast extract can gently and effectively promote the renewal cycle of the stratum corneum and promote skin self-renewal, improving skin whitening; and Chondrus Crispus extract has significant anti-inflammatory and antioxidant properties.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] (1) The present invention adopts a combination of saccharide isomers, tranexamic acid, Chondrus crispus extract, tea extract, yeast extract and plant whitening agents as antioxidant whitening ingredients, which solves the problem that the existing antioxidant whitening agents have relatively single ingredients. Through the synergistic effect between the components, an antioxidant whitening composition is prepared that effectively inhibits tyrosinase activity and melanin formation from the source, inhibits skin darkening and spot formation at the cellular level, promotes the renewal cycle of the stratum corneum and promotes skin self-renewal, and effectively improves skin whitening.

[0024] (2) The present invention uses propylene glycol, caprylhydroxamic acid, and glyceryl caprylate as preservative components, which are less irritating than traditional paraben preservative components on the market. At the same time, it is combined with natural plant anti-allergic agents, which have anti-inflammatory, anti-allergic, moisturizing and other effects, making the prepared antioxidant whitening composition more gentle and suitable for people with different skin types. DETAILED DESCRIPTION

[0025] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0026] In the Examples and Comparative Examples, the experimental methods used are conventional methods unless otherwise specified, and the materials and reagents used are commercially available unless otherwise specified.

[0027] The raw materials used in the present invention are all conventional commercially available commodities.

[0028] For example, the carbohydrate isomers described in the present invention were purchased from BioSpectrum in South Korea under the trade name Waterin TM ;

[0029] The tranexamic acid was purchased from Jiangxi Tongde Chemical Technology Co., Ltd. under the trade name of tranexamic acid;

[0030] The safflower seed oil, bisabolol, and tocopherol were purchased from BioSpectrum of South Korea under the trade name MelaNo;

[0031] The anti-allergic agent was purchased from BioSpectrum of South Korea under the trade name Calm

[0032] The yeast extract was purchased from BioSpectrum of South Korea under the trade name DermalRx SRC;

[0033] The extract of Chondrus crispus was purchased from Biocogent, USA, under the trade name HYDRANT;

[0034] The tea extract was purchased from Biocogent, USA, with the trade name Scavenox TM GTE.

[0035] The specific components of the plant whitening agent, anti-allergic agent, thickener and preservative in the Examples and Comparative Examples of the present invention are as follows:

[0036] The plant whitening agent is safflower seed oil, bisabolol and tocopherol;

[0037] The anti-allergic agents are Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, Licorice root extract, Chamomile flower extract and Rosemary leaf extract;

[0038] The thickener is hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer;

[0039] The preservatives are propylene glycol, caprylhydroxamic acid, and glyceryl caprylate.

[0040] Example 1: Antioxidant whitening composition of the present invention and preparation method thereof

[0041] Every 100 parts of the antioxidant whitening composition includes the following raw materials: 0.1 parts of saccharide isomers, 0.2 parts of tranexamic acid, 0.5 parts of crispy chondrus crispus extract, 0.2 parts of tea extract, 1.0 parts of yeast extract, 0.2 parts of plant whitening agent, 0.2 parts of thickener, 0.2 parts of anti-allergic agent, 0.2 parts of preservative, and the balance of water.

[0042] Preparation method:

[0043] S1. Add the formulated amount of carbohydrate isomers, tranexamic acid, and water in sequence, heat to 82°C, and stir evenly to obtain a mixed solution A;

[0044] S2. Add the formulated amount of thickener and plant whitening agent to the mixed solution A obtained in step S1, disperse them evenly, homogenize at 2500 rpm for 5 minutes, and keep warm for 5 minutes to obtain mixed solution B;

[0045] S3. Stir and cool the mixed solution B obtained in step S2 to 65° C., add the formulated amount of preservatives, stir evenly, keep warm for 9 minutes, cool to 30° C., add the formulated amount of anti-allergic agent, Chondrus crispus extract, tea extract, and yeast extract, and stir evenly to obtain an antioxidant whitening composition.

[0046] Example 2: Antioxidant whitening composition of the present invention and preparation method thereof

[0047] Every 100 parts of the antioxidant whitening composition includes the following raw materials: 5.0 parts of saccharide isomers, 2.5 parts of tranexamic acid, 10 parts of crispy chondrus crispus extract, 2.5 parts of tea extract, 4.0 parts of yeast extract, 3.0 parts of plant whitening agent, 0.8 part of thickener, 5.0 parts of anti-allergic agent, 0.5 part of preservative, and the balance of water.

[0048] Preparation method:

[0049] S1. Add the formulated amount of carbohydrate isomers, tranexamic acid, and water in sequence, heat to 83°C, and stir evenly to obtain a mixed solution A;

[0050] S2. Add the formulated amount of thickener and plant whitening agent to the mixed solution A obtained in step S1, disperse them evenly, homogenize at 2800 rpm for 7 minutes, and keep warm for 6 minutes to obtain mixed solution B;

[0051] S3. Stir and cool the mixed solution B obtained in step S2 to 60° C., add the formulated amount of preservatives, stir evenly, keep warm for 10 minutes, cool to 35° C., add the formulated amount of anti-allergic agent, Chondrus crispus extract, tea extract, and yeast extract, and stir evenly to obtain an antioxidant whitening composition.

[0052] Example 3: Antioxidant whitening composition of the present invention and preparation method thereof

[0053] Every 100 parts of the antioxidant whitening composition includes the following raw materials: 0.5 parts of carbohydrate isomers, 1.0 parts of tranexamic acid, 1.5 parts of crispy chondrus crispus extract, 1.5 parts of tea extract, 2.5 parts of yeast extract, 1.0 parts of plant whitening agent, 0.5 parts of thickener, 0.5 parts of anti-allergic agent, 0.4 parts of preservative, and the balance of water.

[0054] Preparation method:

[0055] S1. Add the formulated amount of carbohydrate isomers, tranexamic acid, and water in sequence, heat to 83°C, and stir evenly to obtain a mixed solution A;

[0056] S2. Add the formulated amount of thickener and plant whitening agent to the mixed solution A obtained in step S1, disperse them evenly, homogenize at 2800 rpm for 7 minutes, and keep warm for 6 minutes to obtain mixed solution B;

[0057] S3. Stir and cool the mixed solution B obtained in step S2 to 55° C., add the formulated amount of preservatives, stir evenly, keep warm for 10 minutes, cool to 35° C., add the formulated amount of anti-allergic agent, Chondrus crispus extract, tea extract, and yeast extract, and stir evenly to obtain an antioxidant whitening composition.

[0058] Example 4: Antioxidant whitening composition of the present invention and preparation method thereof

[0059] Every 100 parts of the antioxidant whitening composition includes the following raw materials: 0.2 parts of carbohydrate isomers, 0.8 parts of tranexamic acid, 1.0 parts of crispy chondrus crispus extract, 1.0 parts of tea extract, 2.0 parts of yeast extract, 0.5 parts of plant whitening agent, 0.3 parts of thickener, 0.3 parts of anti-allergic agent, 0.3 parts of preservative, and the balance of water.

[0060] Preparation method:

[0061] S1. Add the formulated amount of carbohydrate isomers, tranexamic acid, and water in sequence, heat to 85°C, and stir evenly to obtain a mixed solution A;

[0062] S2. Add the formulated amount of thickener and plant whitening agent to the mixed solution A obtained in step S1, disperse them evenly, homogenize at 3000 rpm for 8 minutes, and keep warm for 7 minutes to obtain mixed solution B;

[0063] S3. Stir and cool the mixed solution B obtained in step S2 to 70° C., add the formulated amount of preservatives, stir evenly, keep warm for 12 minutes, cool to 40° C., add the formulated amount of anti-allergic agent, Chondrus crispus extract, tea extract, and yeast extract, and stir evenly to obtain an antioxidant whitening composition.

[0064] Example 5: Antioxidant whitening composition of the present invention and preparation method thereof

[0065] Every 100 parts of the antioxidant whitening composition includes the following raw materials: 1.0 parts of saccharide isomers, 1.5 parts of tranexamic acid, 5.0 parts of crispy chondrus crispus extract, 2.0 parts of tea extract, 3.0 parts of yeast extract, 2.0 parts of plant whitening agent, 0.6 parts of thickener, 2.0 parts of anti-allergic agent, 0.4 parts of preservative, and the balance of water.

[0066] The preparation method is the same as Example 3.

[0067] Comparative Example 1

[0068] Compared with Example 3, the only difference of this comparative example is that it does not contain saccharide isomers, Chondrus crispus extract and tea extract.

[0069] The preparation method is similar to that in Example 3.

[0070] Comparative Example 2

[0071] Compared with Example 3, the only difference of this comparative example is that it does not contain tea extract.

[0072] The preparation method is similar to that in Example 3.

[0073] Comparative Example 3

[0074] Compared with Example 3, the only difference of this comparative example is that it does not contain saccharide isomers.

[0075] The preparation method is similar to that in Example 3.

[0076] Comparative Example 4

[0077] Compared with Example 3, the only difference of this comparative example is that the Chondrus crispus extract is replaced with an equal amount of carnosine.

[0078] The preparation method is similar to that in Example 3.

[0079] Test Example 1: Spot Removal and Whitening Effect Test

[0080] 1. Experimental samples

[0081] The antioxidant whitening compositions prepared in Examples 1 to 5 and Comparative Examples 1 to 4.

[0082] 2. Experimental Methods

[0083] 135 volunteers with facial spots were selected and randomly divided into 9 groups, with 15 people in each group. The same sample was used for volunteers in the same group. There was no abnormality in the skin of the tested areas of all subjects, and subjects with sensitive skin were excluded.

[0084] The VISA tester was used to extract the subject's spot index and skin whiteness data before using the product, 14 days after using the product, and 28 days after using the product to determine the subject's skin changes. The specific data are shown in Table 1:

[0085] Table 1 Spot index change (average) and skin whiteness change (average) data of each sample after using the product for 14 days and 28 days

[0086]

[0087]

[0088] From the data in Table 1, it can be seen that the antioxidant whitening compositions prepared in Examples 1 to 5 of the present invention can significantly reduce the skin spot index and significantly improve the skin whiteness value within 28 days of use.

[0089] Comparative Example 1 does not contain carbohydrate isomers, crispa extract and tea extract, and the change value (absolute value) of the skin spot index is only 6.04%, which is significantly lower than that of the example, and the skin whiteness value is also significantly lower than that of the example; Comparative Example 2 does not contain tea extract, Comparative Example 3 does not contain carbohydrate isomers, and Comparative Example 4 uses an equal amount of carnosine instead of crispa extract. The freckle removal and skin brightening effects of the compositions prepared in the three comparative examples are all worse than those in the example, indicating that the synergistic effect between carbohydrate isomers, crispa extract and tea extract can significantly improve the freckle removal and whitening effects of the antioxidant whitening composition.

[0090] Test Example 2: Antioxidant Effect Test

[0091] 1. Experimental samples

[0092] The antioxidant whitening compositions prepared in Examples 1 to 5 and Comparative Examples 1 to 4.

[0093] 2. Experimental Methods

[0094] DPPH free radical scavenging activity assay:

[0095] Using DPPH-ethanol solution as the control, measure the absorbance A0 at a wavelength of 517nm, and read the results three times in parallel; draw 1mL of sample into a test tube, add 4.5mL of 0.1mmol / L DPPH-ethanol solution, shake thoroughly and react in the dark for 30min, measure the absorbance A1 at a wavelength of 517nm, and read the results three times in parallel. Take the average to obtain the DPPH clearance rate of each sample.

[0096] The calculation formula is: DPPH clearance rate = (1-A1 / A0) × 100%

[0097] Table 2 DPPH free radical scavenging rate of each sample (%)

[0098] Group Free radical scavenging rate (%) Example 1 85.52 Example 2 91.32 Example 3 92.13 Example 4 88.67 Example 5 90.07 Comparative Example 1 41.38 Comparative Example 2 53.64 Comparative Example 3 55.71 Comparative Example 4 63.46

[0099] As can be seen from Table 2, the antioxidant whitening compositions prepared in Examples 1 to 5 have good antioxidant activity, and the DPPH free radical scavenging rate can be maintained above 85%, and can reach a maximum of 92.13%.

[0100] Comparative Example 1 does not contain carbohydrate isomers, crispa extract and tea extract, Comparative Example 2 does not contain tea extract, Comparative Example 3 does not contain carbohydrate isomers, and Comparative Example 4 uses an equal amount of carnosine instead of crispa extract. The DPPH radical scavenging rates of Comparative Examples 1 to 4 are significantly worse than those of the examples, which shows that the synergistic effect of the components in the present invention can effectively enhance the antioxidant activity of the composition.

[0101] Test Example 3: Safety Test

[0102] Patch test: Examples 1-5 were subjected to human safety patch tests. The test method was based on the human skin patch test in the "2015 Cosmetic Safety Technical Specifications". The method of the skin occlusion patch test was as follows: 30 people aged 18-60 were selected, and the area of ​​the patch was no more than 50 mm. 2 Qualified spot test equipment with a depth of approximately 1mm was used. 0.020mL of sample was placed into the spot test chamber. The control well served as a blank control (no substance was placed). The spot test chamber containing the repair and firming composition was applied to the subject's flexed forearm using hypoallergenic tape. Gently press the patch evenly onto the skin using the palm of your hand for 24 hours. Skin reactions were observed according to the criteria in Table 3 30 minutes (after the indentation disappears), 24 hours, and 48 hours after removal of the spot test chamber containing the repair and firming composition. The results were recorded as shown in Table 4.

[0103] Table 3 Skin reaction grading standards for occlusive patch test

[0104]

[0105]

[0106] Table 4 Patch test results

[0107] Sample number 30min 24h 48h Overall results Example 1 0 0 0 All 30 people had no positive reaction Example 2 0 0 0 All 30 people had no positive reaction Example 3 0 0 0 All 30 people had no positive reaction Example 4 0 0 0 All 30 people had no positive reaction Example 5 0 0 0 All 30 people had no positive reaction

[0108] As can be seen from the above table, the patch test results of Examples 1-5 are all negative, indicating that the composition of the present invention is mild and non-irritating.

[0109] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the present invention. Anyone skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by one of ordinary skill in the art without departing from the spirit and technical principles disclosed herein are intended to be covered by the claims of the present invention.

Claims

1. An antioxidant whitening composition, characterized in that: Every 100 parts of the antioxidant whitening composition include the following components in parts by weight: 0.5 parts of saccharide isomers, 1.0 parts of tranexamic acid, 1.5 parts of crisp chondrus crispus extract, 1.5 parts of tea extract, 2.5 parts of yeast extract, 1.0 parts of plant whitening agent, 0.5 parts of thickener, 0.5 parts of anti-allergic agent, 0.4 parts of preservative, and the balance of water; the plant whitening agent is a mixture of safflower seed oil, bisabolol, and tocopherol; the trade name of the plant whitening agent is MelaNo; the anti-allergic agent is a mixture of Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, Glycyrrhiza glabra root extract, Chamomile flower extract, and Rosemary leaf extract; the trade name of the anti-allergic agent is Calm Yang®; the thickener is hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer; the preservative is a mixture of propylene glycol, caprylhydroxamic acid, and glyceryl caprylate.

2. A method for preparing the antioxidant whitening composition according to claim 1, characterized in that: The following steps are involved: S1. Add the formulated amount of carbohydrate isomers, tranexamic acid, and water in sequence, heat, and stir evenly to obtain a mixed solution A; S2. Add the formulated amount of thickener and plant whitening agent to the mixed solution A obtained in step S1, disperse evenly, homogenize, and keep warm to obtain mixed solution B; S3. Stir and cool the mixed solution B obtained in step S2 to below 75° C., add the formulated amount of preservatives, stir evenly, keep warm, cool to 30-40° C., add the formulated amount of anti-allergic agent, Chondrus crispus extract, tea extract, and yeast extract, and stir evenly to obtain an antioxidant whitening composition.

3. The preparation method according to claim 2, wherein The heating in step S1 is to heat to 82-85°C.

4. The preparation method according to claim 3, wherein The homogenization speed in step S2 is 2500-3000 rpm, and the homogenization time is 5-8 minutes.

5. The preparation method according to claim 4, wherein The holding time in step S2 is 5 to 7 minutes; the holding time in step S3 is 9 to 12 minutes.

6. Use of the antioxidant whitening composition according to claim 1 in the preparation of cosmetics.

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