Simulated moving bed separation system

Abstract

The application discloses a simulated moving bed separation system. The system comprises a separation unit, m first multi-way electromagnetic valves and k second multi-way electromagnetic valves, and the separation unit comprises n adsorption columns; the first multi-way electromagnetic valve comprises first, second and third interfaces, wherein the first interface is connected with the lower part of one adsorption column, the second interface is connected with the inlet of a desorbent circulating unit, and the third interface is connected with the upper part of another adsorption column; the second multi-way electromagnetic valve comprises first, second, third, fourth and fifth interfaces, wherein the first interface is connected with a desorbent feeding unit, the second interface is connected with a draw-off liquid discharging unit, the third interface is connected with a material to be separated feeding unit, the fourth interface is connected with a raffinate discharging unit, and the fifth interface is connected with the lower part of the adsorption column. The simulated moving bed separation system can not only realize flexible conversion between fixed beds and simulated moving beds, but also can flexibly adjust the number and distribution mode of the adsorption columns in different functional areas under the simulated moving bed mode.

Description

Technical Field

[0001] This invention belongs to the field of separation technology, and more specifically, relates to a simulated moving bed separation system. Background Technology

[0002] Simulated moving bed chromatography is a continuous preparative chromatography technique that utilizes valve switching technology to change the positions of the injector, mobile phase injection point, and separation and collection point, achieving countercurrent operation. Simulated moving bed adsorption separation technology is a highly efficient and advanced separation and purification technology belonging to the high-tech industry. It can continuously, efficiently, and inexpensively separate substances that are difficult to separate using conventional methods. It exhibits unique separation characteristics in the separation of isomers with similar boiling points that are difficult to separate by distillation methods, and its superior purification capabilities are particularly evident in the separation of chiral drugs. Currently, it is widely used abroad in petrochemical, food, fine chemical, bio-fermentation, and pharmaceutical fields.

[0003] The operating unit of simulated moving bed chromatography is chromatographic chromatography, which utilizes the differences in the adsorption properties of a certain adsorbent on a matrix. Through an adsorption-elution process, it separates several substances with very similar properties, mainly by taking advantage of the different migration rates of various components in the chromatographic column, that is, the differences in the adsorption and partition coefficients of each component in the stationary and mobile phases, to achieve the purpose of separation. In a countercurrent simulated moving bed chromatographic separation system, the stationary phase can be imagined to move against the direction of fluid movement. The analytes to be separated are continuously fed into the separation zone at a certain point in the middle. With the bidirectional flow rate ratio selected, the feed liquid is separated into two bidirectional flowing parts from the inlet. With the feed inlet as a reference point, the adsorption medium appears to adsorb the product and move upward, hence the name "simulated moving bed". Simulated moving bed systems typically have two feed streams and two discharge streams: one for raw material and one for desorbent; and two for extractant and raffinate. These two feed streams divide the system into four functional zones. The relative countercurrent flow of the stationary and mobile phases can be simulated by adjusting the inlet and outlet positions of the raw material and desorbent feeds, as well as the outlet positions of the extractant and raffinate. In existing simulated moving bed systems, the changes in feed and outlet positions are usually achieved through rotary valves or automatic control valves, resulting in limited flexibility. Once the number of adsorption columns in each functional zone is determined and installed, it is difficult to adjust the number of columns in different zones. This makes the simulated moving bed system poorly adaptable to different separation systems, limiting its separation capabilities. Summary of the Invention

[0004] This invention is primarily based on the following problems and findings:

[0005] Currently, much research has been conducted on the improvement and optimization of simulated moving beds. For example, a liquid-phase simulated moving bed adsorption separation system has been proposed, as well as a high-efficiency simulated moving bed device. This device includes the essential components of a simulated moving bed, such as an adsorption bed, a raw material feeding system, a desorbent feeding system, a circulation system, an extractant system, and a residual liquid system. In addition, a programmable valve group is used to replace the traditional multi-channel rotary valve to control the cycle switching of the simulated moving bed, which can reduce the cost of the equipment. However, it does not achieve the function of flexibly adjusting the number of adsorption columns in different regions.

[0006] In view of this, the present invention aims to at least partially solve one of the technical problems in the related art. Therefore, the object of the present invention is to propose a simulated moving bed separation system. This simulated moving bed separation system not only allows for flexible switching between fixed beds and simulated moving beds, but also allows for flexible adjustment of the number and distribution of adsorption columns in different functional zones within the simulated moving bed mode. This is beneficial for improving the adaptability of the simulated moving bed to different separation systems and for broadening the application range of separable systems.

[0007] In one aspect of the invention, a simulated moving bed separation system is provided. According to an embodiment of the invention, the system includes:

[0008] The separation unit comprises n adsorption columns arranged sequentially.

[0009] m first multi-port solenoid valves, each first multi-port solenoid valve including a first interface, a second interface and a third interface, wherein the first interface of the first multi-port solenoid valve is connected to the lower part of one of the adsorption columns, the second interface is connected to the inlet of the desorbent circulation unit, and the third interface is connected to the upper part of another adsorption column.

[0010] k second multi-way solenoid valves, each second multi-way solenoid valve including a first interface, a second interface, a third interface, a fourth interface, and a fifth interface. The first interface of the second multi-way solenoid valve is connected to the desorbent feeding unit, the second interface is connected to the extractant discharge unit, the third interface is connected to the material to be separated feeding unit, the fourth interface is connected to the residual liquid discharge unit, and the fifth interface is connected to the lower part of the adsorption column.

[0011] The outlet of the desorbent circulation unit is connected to the desorbent feeding unit, and n, m, and k are all positive integers, n ≥ m, k and n ≥ 2.

[0012] According to the simulated moving bed separation system of the above embodiments of the present invention, by setting m first multi-way solenoid valves, each having at least three interfaces, and controlling their connection method, multiple adsorption columns can be connected in series and different states of connection between the adsorption columns and the circulation unit can be switched according to actual needs. Simultaneously, by setting k second multi-way solenoid valves, each having at least five interfaces, and controlling their connection method, the adsorption columns can be arbitrarily switched between connected and disconnected states with the desorbent feeding unit, the extractant discharge unit, the material to be separated feeding unit, and the residual liquid discharge unit, respectively, according to actual needs. Furthermore, through the cooperation of the first and second multi-way solenoid valves, flexible switching between fixed bed and simulated moving bed modes can be achieved, which not only improves the usability for different separation systems... The system offers flexibility, allowing for the determination of separation process parameters based on the separation effect and process in fixed beds and simulated moving beds. This not only reduces the difficulty of parameter determination but also improves the reliability of process parameters. Furthermore, by setting the connection method of the first and second multi-way solenoid valves, the multi-way solenoid valves at the inlet and outlet of the adsorption column can be switched according to different state switching sequences. This enables flexible adjustment of the number of adsorption columns in each region of the simulated moving bed, thereby increasing the application range of the simulated moving bed and further reducing resource waste while ensuring separation effect. In addition, the use of multi-way solenoid valves simplifies the system structure, optimizes the system's footprint, and facilitates automated control.

[0013] In addition, the simulated moving bed separation system according to the above embodiments of the present invention may also have the following additional technical features:

[0014] In some embodiments of the present invention, each of the adsorption columns is connected to at least one first multi-way solenoid valve, and the lower part of each adsorption column is connected to a second multi-way solenoid valve.

[0015] In some embodiments of the present invention, a plurality of adsorption columns are connected end to end by a plurality of first multi-way solenoid valves.

[0016] In some embodiments of the present invention, the first port and the second port of the first multi-way solenoid valve are not opened simultaneously.

[0017] In some embodiments of the present invention, the first port, the second port, the third port and the fourth port of the second multi-way solenoid valve may have only one port open or all ports closed at the same time.

[0018] In some embodiments of the present invention, the value of n ranges from 4 to 32.

[0019] In some embodiments of the present invention, the simulated moving bed separation system further includes an automatic control unit, which is connected to the first multi-way solenoid valve and the second multi-way solenoid valve, and controls the opening and closing of each port of the first multi-way solenoid valve and the opening and closing of each port of the second multi-way solenoid valve.

[0020] In some embodiments of the present invention, the holding time for opening or closing different ports of the first multi-way solenoid valve is 50 to 4000 s, and / or the holding time for opening or closing different ports of the second multi-way solenoid valve is 50 to 4000 s.

[0021] In some embodiments of the present invention, the material feeding unit to be separated includes a first storage device, which is connected to the third interface of the second multi-way solenoid valve via a first delivery pump.

[0022] In some embodiments of the present invention, the material feeding unit to be separated further includes a first preheating device and / or a first metering device, wherein the first preheating device is disposed adjacent to the third interface of the second multi-way solenoid valve; the first metering device is connected to the first storage device.

[0023] In some embodiments of the present invention, the flow rate of the first delivery pump is 1 ml / min to 20 ml / min.

[0024] In some embodiments of the present invention, the desorbent feeding unit includes a second storage device, which is connected to the first interface of the second multi-way solenoid valve via a second delivery pump.

[0025] In some embodiments of the present invention, the desorbent feeding unit further includes a second preheating device and / or a second metering device, wherein the second preheating device is disposed adjacent to the first interface of the second multi-way solenoid valve; and the second metering device is connected to the second storage device.

[0026] In some embodiments of the present invention, the flow rate of the second delivery pump is 1 ml / min to 50 ml / min.

[0027] In some embodiments of the present invention, the extractable liquid discharge unit includes: a first cooling device and a third delivery pump, the third delivery pump being connected to the second interface of the second multi-way solenoid valve, and the first cooling device being disposed adjacent to the inlet end of the third delivery pump.

[0028] In some embodiments of the present invention, the flow rate of the third delivery pump is 1 ml / min to 50 ml / min.

[0029] In some embodiments of the present invention, the residual liquid discharge unit includes: a second cooling device, the inlet of the second cooling device being connected to the fourth interface of the second multi-way solenoid valve, and the outlet of the second cooling device being connected to the back pressure valve.

[0030] In some embodiments of the present invention, the desorbent circulation unit includes: a circulation pump, the inlet of which is connected to the second interface of the first multi-way solenoid valve through a circulation pipeline, and the outlet of which is connected to the desorbent feeding unit.

[0031] In some embodiments of the present invention, the desorbent circulation unit further includes a third cooling device disposed adjacent to the inlet end of the circulation pump.

[0032] In some embodiments of the present invention, the desorbent circulation unit further includes a one-way valve and a flow meter, wherein the one-way valve is connected to the circulation pipeline and the flow meter is connected to the circulation pump.

[0033] In some embodiments of the present invention, the flow rate of the circulating pump is 1 ml / min to 100 ml / min.

[0034] In some embodiments of the present invention, the adsorption column is provided with a temperature measuring device.

[0035] In some embodiments of the present invention, the separation unit is provided with a heating device and / or a gas flow device.

[0036] In some embodiments of the present invention, the temperature inside the adsorption column is 20–220°C.

[0037] In some embodiments of the present invention, a pressure sensor and / or a safety valve are provided at the inlet of the adsorption column.

[0038] In some embodiments of the present invention, the pressure of the liquid inside the adsorption column is 0.1 MPa to 3.0 MPa.

[0039] In some embodiments of the present invention, the automatic control unit is connected to at least one of the separation unit, the material to be separated feeding unit, the desorbent feeding unit, the extractant discharge unit, and the residual liquid extraction unit, and monitors the temperature and / or pressure within the system.

[0040] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0041] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0042] Figure 1 This is a schematic diagram of a simulated moving bed separation system according to an embodiment of the present invention;

[0043] Figure 2 This is a schematic diagram of a simulated moving bed separation system according to another embodiment of the present invention. Detailed Implementation

[0044] Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0045] In the description of this invention, it should be understood that the terms "upper," "lower," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0046] In this invention, unless otherwise explicitly specified and limited, terms such as "installation," "connection," "joining," and "fixing" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances. In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact through an intermediate medium. Furthermore, "above," "on top of," and "on top" can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0047] In one aspect of the invention, a simulated moving bed separation system is proposed. According to an embodiment of the invention, combined with... Figures 1-2 The system comprises: a separation unit 300, m first multi-way solenoid valves 100, and k second multi-way solenoid valves 200. The separation unit includes n adsorption columns 310 arranged sequentially. Each first multi-way solenoid valve 100 includes a first port 110, a second port 120, and a third port 130. The first port 110 is connected to the lower part of one adsorption column 310, the second port 120 is connected to the inlet of the desorbent circulation unit 400, and the third port 130 is connected to the upper part of another adsorption column 310. Each second multi-way solenoid valve 200 includes a first port 210. 0. Second interface 220, third interface 230, fourth interface 240 and fifth interface 250, the first interface 210 of the second multi-way solenoid valve 200 is connected to the desorbent feeding unit 500, the second interface 220 is connected to the extractant discharge unit 600, the third interface 230 is connected to the material to be separated feeding unit 700, the fourth interface 240 is connected to the residual liquid discharge unit 800, and the fifth interface 250 is connected to the lower part of the adsorption column 310. The outlet of the desorbent circulation unit 400 is connected to the desorbent feeding unit. n, m and k are all positive integers, n≥m, k and n≥2.

[0048] According to the simulated moving bed separation system of the above embodiments of the present invention, by setting m first multi-way solenoid valves, each having at least three interfaces, and controlling their connection method, multiple adsorption columns can be connected in series and different states of connection between the adsorption columns and the circulation unit can be switched according to actual needs. Simultaneously, by setting k second multi-way solenoid valves, each having at least five interfaces, and controlling their connection method, the adsorption columns can be arbitrarily switched between connected and disconnected states with the desorbent feeding unit, the extractant discharge unit, the material to be separated feeding unit, and the residual liquid discharge unit, respectively, according to actual needs. Furthermore, through the cooperation of the first and second multi-way solenoid valves, flexible switching between fixed bed and simulated moving bed modes can be achieved, which not only improves the usability for different separation systems... The system offers flexibility, allowing for the determination of separation process parameters based on the separation performance and process in fixed beds and simulated moving beds. This not only reduces the difficulty of parameter determination but also improves the reliability of the process parameters. Furthermore, by setting the connection method of the first and second multi-way solenoid valves, and controlling the switching of the multi-way solenoid valves at the inlet and outlet of the adsorption column according to different state switching sequences, the number of adsorption columns in each region of the simulated moving bed can be flexibly adjusted. This not only increases the application range of the simulated moving bed but also helps to further reduce resource waste while ensuring separation performance. Additionally, the use of multi-way solenoid valves simplifies the system structure, optimizing the system's footprint and facilitating automated control.

[0049] According to an embodiment of the present invention, the material to be separated feeding unit 700, the desorbent feeding unit 500, the extract discharge unit 600, and the raffinate discharge unit 800 can divide the simulated moving bed separation system into four regions, namely the adsorption zone, the distillation zone, the desorption zone, and the buffer zone. Specifically, the area between the material to be separated feeding unit 700 and the raffinate discharge unit 800 is an adsorption zone, where strongly retained products are adsorbed and discharged from the raffinate discharge unit; the area between the extractable liquid discharge unit 600 and the material to be separated feeding unit 700 is a distillation zone, where weakly retained products are eluted and discharged from the extractable liquid discharge unit; the area between the desorbent feeding unit 500 and the extractable liquid discharge unit 600 is a desorption zone, also known as a "stationary phase regeneration zone," where the material to be separated is desorbed, achieving purification of the stationary phase; and the area between the raffinate discharge unit 800 and the desorbent feeding unit 500 is a buffer zone, through which the desorbent can be recycled back to the desorption zone for reuse.

[0050] According to an embodiment of the present invention, in combination Figure 1It is understood that the first port 110 and the second port 120 of the first multi-way solenoid valve 100 may not be opened at the same time, thereby enabling multiple adsorption columns to be connected in series or connecting the adsorption columns to the desorbent circulation unit; furthermore, the first port 210, the second port 220, the third port 230 and the fourth port 240 of the second multi-way solenoid valve 200 may have only one port open at the same time or all ports may remain closed, thereby controlling any one or a group of adsorption columns 310 to be located in any functional area of ​​the adsorption zone, distillation zone, desorption zone or buffer zone.

[0051] According to an embodiment of the present invention, in combination Figure 1 Each adsorption column 310 can be connected to at least one first multi-way solenoid valve 100, and the lower part of each adsorption column 310 can be connected to a second multi-way solenoid valve 200. This satisfies n = m = k, allowing each adsorption column 310 to have its connection status controlled within the entire simulated moving bed separation system via the first multi-way solenoid valve 100 and the second multi-way solenoid valve 200. This also allows for more flexible adjustment of the number of adsorption columns in each functional area, further improving the flexibility of the entire separation system. For example, according to some specific examples of the present invention, multiple adsorption columns 310 can be connected end-to-end via multiple first multi-way solenoid valves 100. Specifically, n adsorption columns can be connected end-to-end, or a portion of the adsorption columns can be connected end-to-end while another portion is connected to the desorbent circulation unit, etc. Furthermore, according to some specific examples of the present invention, the value of n is not particularly limited, and those skilled in the art can flexibly select it according to actual conditions. For example, n can be 4 to 32, specifically 8, 16, 20, 24, or 28, etc.

[0052] According to an embodiment of the present invention, the system may further include: an automatic control unit (not shown in the figure), which can be connected to the first multi-way solenoid valve 100 and the second multi-way solenoid valve 200, and control the opening and closing of each port of the first multi-way solenoid valve 100 and the second multi-way solenoid valve 200. This allows the inlet and outlet of the adsorption column to be automatically switched in different ways, thereby more flexibly realizing the transformation between fixed bed and simulated moving bed modes, and realizing the flexible adjustment of the number of adsorption columns in the "adsorption zone-distillation zone-desorption zone-buffer zone" in the simulated moving bed. In addition, it is also beneficial to control the operating accuracy and improve the operating efficiency.

[0053] According to an embodiment of the present invention, in combination Figure 1It is understood that the holding time for opening or closing different ports of the first multi-way solenoid valve 100 can be from 50 to 4000 seconds, for example, 100 seconds, 500 seconds, 1000 seconds, 2000 seconds, or 3000 seconds, etc. Similarly, the holding time for opening or closing different ports of the second multi-way solenoid valve 200 can be from 50 to 4000 seconds, for example, 100 seconds, 500 seconds, 1000 seconds, 2000 seconds, or 3000 seconds, etc. It should be noted that the holding time for opening or closing different ports of the first multi-way solenoid valve 100 and the second multi-way solenoid valve 200 can be the same or different. The specific time needs to be determined based on the specific separation system, and those skilled in the art can flexibly choose according to the actual situation.

[0054] According to an embodiment of the present invention, the material feeding unit 700 may include a first storage device 710, which is connected to the third interface 230 of the second multi-way solenoid valve 200 via a first delivery pump 720. By providing the first storage device 710 and the first delivery pump 720, it is beneficial to improve the conveying efficiency of the material to be separated and control its flow rate. According to some specific examples of the present invention, the flow rate of the first delivery pump 720 may be 1 ml / min to 20 ml / min, for example, 5 ml / min, 10 ml / min, or 15 ml / min. The present invention does not impose any particular limitation on the specific feed flow rate of the material to be separated, and those skilled in the art can flexibly select the appropriate flow rate according to actual conditions.

[0055] According to an embodiment of the present invention, in combination Figure 1 It is understood that the material feeding unit 700 may include a first preheating device 730. The first preheating device 730 may be set adjacent to the third interface 230 of the second multi-way solenoid valve 200, thereby preheating the material to be separated before it is input into the separation unit. This is beneficial to improve the heating rate of the material to be separated in the separation unit and the temperature uniformity in the adsorption column, thereby improving the separation efficiency and separation effect. It should be noted that there are no particular restrictions on the specific type and location of the first preheating device 730 in this invention. Those skilled in the art can flexibly choose according to actual needs. For example, it may be a preheater, which may be set between the first conveying pump 720 and the third interface 230 of the second multi-way solenoid valve 200. For another example, the first preheating device 730 may be sleeved on the conveying pipeline located between the first conveying pump 720 and the third interface 230 of the second multi-way solenoid valve 200.

[0056] According to an embodiment of the present invention, the material feeding unit 700 to be separated may further include a first metering device (not shown in the figure). The first metering device may be connected to the first storage device 710 and used to meter the input amount of the material to be separated. In the present invention, there is no particular limitation on the specific type of the first metering device. Those skilled in the art can flexibly select it according to the actual situation. For example, the first storage device 710 may be weighed by a weighing scale, and then the input amount of the material to be separated may be calculated based on the reading of the weighing scale.

[0057] According to an embodiment of the present invention, in combination Figure 1 It is understood that, similar in structure to the material feeding unit 700, the desorbent feeding unit 500 may also include a second storage device 510, a second preheating device 530, and a second metering device (not shown in the figure). The second storage device 510 can be connected to the first interface 210 of the second multi-way solenoid valve 200 via the second delivery pump 520. Similarly, the manner and purpose of setting up the second storage device 510, the second preheating device 530, and the second metering device are the same as those of the first storage device 710, the first preheating device 730, and the second metering device, and will not be repeated here. In addition, according to some specific examples of the present invention, the flow rate of the second delivery pump can be from 1 ml / min to 50 ml / min, for example, it can be 10 ml / min, 20 ml / min, 30 ml / min, or 40 ml / min, etc. There is no particular limitation on the specific feed flow rate of the material to be separated in the present invention, and those skilled in the art can flexibly choose according to the actual situation.

[0058] According to an embodiment of the present invention, in combination Figure 1 It is understood that the extractant discharge unit 600 may include a first cooling device 610 and a third transfer pump 620. The third transfer pump 620 is connected to the second port 220 of the second multi-way solenoid valve 200. The first cooling device 610 is located adjacent to the inlet of the third transfer pump 620, thereby cooling the separated extractant before it is discharged through the third transfer pump 620. According to some specific examples of the present invention, the flow rate of the third transfer pump can be 1 ml / min to 50 ml / min, for example, 10 ml / min, 20 ml / min, 30 ml / min, 40 ml / min, etc. In addition, the present invention does not have any particular limitations on the specific type and location of the cooling device. Those skilled in the art can flexibly choose according to actual needs. For example, it can be a cooler, which can be set between the third transfer pump 620 and the second port 220 of the second multi-way solenoid valve 200.

[0059] According to an embodiment of the present invention, in combination Figure 1It is understood that the residual liquid discharge unit 800 may include a second cooling device 810. The inlet of the second cooling device 810 may be connected to the fourth port 240 of the second multi-way solenoid valve 200, and the outlet of the second cooling device 810 may be connected to a back pressure valve (not shown in the figure), which is beneficial to control the pipeline pressure and enable the residual liquid to be discharged smoothly.

[0060] According to an embodiment of the present invention, in combination Figure 1 It is understood that the desorbent circulation unit 400 may include a circulation pump 410. The inlet of the circulation pump 410 can be connected to the second port 120 of the first multi-way solenoid valve 100 through a circulation pipeline 420, and the outlet of the circulation pump 410 can be connected to the desorbent feeding unit 500. This helps to overcome the pressure drop of the desorbent circulation unit and allows the desorbent to be smoothly supplied to the desorbent feeding unit 500 for recycling through the circulation unit. Furthermore, according to some specific examples of the present invention, the flow rate of the circulation pump 410 can be from 1 ml / min to 100 ml / min, for example, it can be 10 ml / min, 30 ml / min, 50 ml / min or 70 ml / min, etc., which can be flexibly adjusted by those skilled in the art according to actual conditions.

[0061] According to an embodiment of the present invention, in combination Figure 1 It is understood that the desorbent circulation unit 400 may further include a third cooling device 430, which may be located adjacent to the inlet of the circulation pump 410. For example, the third cooling device may be a cooler, located between the circulation pump 410 and the second port 120 of the first multi-way solenoid valve 100, thereby cooling the desorbent circulation liquid before output. Additionally, the desorbent circulation unit 400 may also include a one-way valve (not shown), which may be connected to the circulation pipeline 420, thereby preventing the desorbent entering the circulation unit from flowing back to the separation unit. Furthermore, the desorbent circulation unit 400 may also include a flow meter (not shown), which may be connected to the circulation pump 410, thereby measuring the output flow rate of the desorbent circulation liquid.

[0062] According to an embodiment of the present invention, in combination Figure 1It is understood that the separation unit 300 may be equipped with a heating device (not shown) for heating the adsorption column; in addition, the separation unit 300 may also be equipped with a gas flow device (not shown), which helps to improve the temperature uniformity within the separation unit 300; furthermore, the adsorption column 310 may be equipped with a temperature measuring device (not shown) for determining whether the temperature of the adsorption column is within the target range. The specific type of temperature measuring device is not particularly limited in this invention, and those skilled in the art can flexibly choose according to actual conditions, such as a thermocouple. Further, according to some specific examples of this invention, the temperature within the adsorption column 310 can be 20–220°C, for example, 50°C, 100°C, 150°C, or 200°C, etc., and those skilled in the art can flexibly adjust it according to actual conditions.

[0063] According to an embodiment of the present invention, in combination Figure 1 It is understood that the pressure of the liquid inside the adsorption column 310 can be from 0.1 MPa to 3.0 MPa, for example, 0.5 MPa, 1 MPa, 1.5 MPa, or 2 MPa, etc., and can be flexibly adjusted by those skilled in the art according to actual conditions. Furthermore, a pressure sensor can be provided at the inlet of the adsorption column 310 to monitor whether the pressure inside the adsorption column is within the expected range. Additionally, according to some specific examples of the present invention, a safety valve can also be provided inside the adsorption column 310 to ensure the safe operation of the system.

[0064] According to an embodiment of the present invention, the automatic control unit can be connected to at least one of the separation unit 300, the material to be separated feeding unit 700, the desorbent feeding unit 500, the extract liquid discharge unit 600, and the residual liquid discharge unit 800, and monitor the temperature and / or pressure within the system. This can further enable automatic control of the flow rates of the first transfer pump 720, the second transfer pump 520, the third transfer pump 620, and the circulation pump 410, and enable the multi-way solenoid valve to automatically switch at a set time, thereby improving the automation level of the system.

[0065] The embodiments of the present invention are described in detail below. These embodiments are exemplary and are only used to explain the present invention, and should not be construed as limiting the invention. Where specific techniques or conditions are not specified in the embodiments, they are performed according to the techniques or conditions described in the literature in the art or according to the product instructions. Reagents or instruments used, unless otherwise specified, are all commercially available conventional products.

[0066] In the following embodiments of the present invention, combined with Figure 1 To understand, taking 8 adsorption columns, 8 first multi-way solenoid valves and 8 second multi-way solenoid valves as an example, the first multi-way solenoid valve connected to the upper end of the nth (n≤8) adsorption column is called 1-n, and the second multi-way solenoid valve connected to the lower end of the nth adsorption column is called 2-n.

[0067] The states of the first multi-way solenoid valve can be as follows:

[0068] 1: Both the first and third interfaces are opened simultaneously;

[0069] 2: Both the second and third interfaces are opened simultaneously;

[0070] The states of the second multi-way solenoid valve can be as follows:

[0071] 1: Both the first and fifth interfaces are opened simultaneously;

[0072] 2: Both the second and fifth interfaces are opened simultaneously;

[0073] 3: Both the third and fifth interfaces are open simultaneously.

[0074] 4: The fourth and fifth interfaces are open;

[0075] 5: Interfaces 1, 2, 3, 4, and 5 are closed simultaneously.

[0076] Example 1

[0077] According to the state switching list of the first and second multi-way solenoid valves shown in Table 1, the eight sets of solenoid valve state combinations are switched sequentially and periodically at regular intervals, so that the simulated moving bed equipment is in a state where the number of adsorption columns in the "adsorption zone-distillation zone-desorption zone-buffer zone" is distributed as "2-2-2-2". The specific connection method of valve state combination 1 can be combined with... Figure 2 understand.

[0078] Table 1. Combination states of the first and second multi-way solenoid valves

[0079]

[0080]

[0081] Example 2

[0082] According to the valve state switching list shown in Table 2, the 8 sets of valve state combinations are switched sequentially at regular intervals, so that the number of adsorption columns in the simulated moving bed equipment is distributed as "1-3-2-2" in the "adsorption zone-distillation zone-desorption zone-buffer zone".

[0083] The difference between this embodiment and embodiment 1 is that in combination state 1, 2-5 in the second multi-way solenoid valve corresponds to state 5, and 2-6 in the second multi-way solenoid valve corresponds to state 3 (in combination state 1 of embodiment 1, 2-5 in the second multi-way solenoid valve corresponds to state 3, and 2-6 in the second multi-way solenoid valve corresponds to state 5).

[0084] Table 2. Combination states of the first and second multi-way solenoid valves

[0085]

[0086] Example 3

[0087] According to the valve state switching list shown in Table 3, the 8 sets of valve state combinations are switched sequentially and periodically at certain intervals, so that the number of adsorption columns in the simulated moving bed equipment is distributed as "2-3-2-1" in the "adsorption zone-distillation zone-desorption zone-buffer zone".

[0088] The difference between this embodiment and embodiment 1 is that in combination state 2, 2-5 in the second multi-way solenoid valve corresponds to state 5, 2-6 corresponds to state 3, 2-7 corresponds to state 5, and 2-8 corresponds to state 4 (in combination state 1 of embodiment 1, 2-5 in the second multi-way solenoid valve corresponds to state 3, 2-6 corresponds to state 5, 2-7 corresponds to state 4, and 2-8 corresponds to state 5).

[0089] Table 3. Combination states of the first and second multi-way solenoid valves

[0090]

[0091]

[0092] Example 4

[0093] By setting the valve status switching list shown in Table 4, the fixed bed mode with the fifth adsorption column (n=5) and the sixth adsorption column (n=6) connected in series can be realized.

[0094] Specifically, by controlling the opening of the first and third ports of 1-5 and 1-6 in the first multi-way solenoid valve, and the opening of the first and second ports of 1-1, 1-2, 1-3, 1-4, 1-7, and 1-8, the fifth and sixth adsorption columns are connected in series, and the first, second, third, fourth, seventh, and eighth adsorption columns are connected to the desorbent circulation unit. At the same time, by controlling the closing of 2-1, 2-2, 2-3, 2-4, 2-6, and 2-8 in the second multi-way solenoid valve, 2-5 is connected to the material feeding unit to be separated and the fifth adsorption column, and 2-7 is connected to the residual liquid discharge unit, so that the fifth and sixth adsorption columns form a fixed bed mode with dual adsorption columns connected in series.

[0095] Table 4. Combination states of the first and second multi-way solenoid valves

[0096]

[0097] Example 5

[0098] By setting the valve status switching list shown in Table 5, the fixed bed mode with four adsorption columns connected in series—the second adsorption column (n=2), the third adsorption column (n=3), the fourth adsorption column (n=4), and the fifth adsorption column (n=5)—can be realized.

[0099] Specifically, by controlling the opening of the first and third ports of 1-2, 1-3, 1-4, and 1-5 in the first multi-way solenoid valve, and the opening of the first and second ports of 1-1, 1-6, 1-7, and 1-8, the second, third, fourth, and fifth adsorption columns are connected in series, and the first, sixth, seventh, and eighth adsorption columns are connected to the desorbent circulation unit. At the same time, by controlling the closing of 2-1, 2-3, 2-4, 2-5, 2-7, and 2-8 in the second multi-way solenoid valve, 2-2 is connected to the material to be separated feeding unit and the fifth adsorption column, and 2-6 is connected to the raffinate discharge unit, thus forming a fixed bed mode with four adsorption columns connected in series.

[0100] Table 4. Combination states of the first and second multi-way solenoid valves

[0101]

[0102] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0103] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. An simulated moving bed separation system characterized by, The application relates to a separation unit, which comprises n adsorption columns arranged in sequence, m first multi-way electromagnetic valves, k second multi-way electromagnetic valves, and an automatic control unit. The first multi-way electromagnetic valves comprise a first interface, a second interface and a third interface, the first interface of the first multi-way electromagnetic valves is connected with the lower part of one adsorption column, the second interface is connected with the inlet of a desorbent circulating unit, and the third interface is connected with the upper part of another adsorption column. The second multi-way electromagnetic valves comprise a first interface, a second interface, a third interface, a fourth interface and a fifth interface, the first interface of the second multi-way electromagnetic valves is connected with a desorbent feeding unit, the second interface is connected with an eluent discharging unit, the third interface is connected with a material to be separated feeding unit, the fourth interface is connected with a raffinate discharging unit, and the fifth interface is connected with the lower part of the adsorption column. The outlet of the desorbent circulating unit is connected with the desorbent feeding unit, n, m and k are positive integers, n is greater than or equal to m and k, and n is greater than or equal to 2. Each adsorption column is connected with at least one first multi-way electromagnetic valve, and the lower part of each adsorption column is connected with one second multi-way electromagnetic valve.

2. The simulated moving bed separation system of claim 1, wherein, The first multi-way electromagnetic valves are connected in sequence through the first multi-way electromagnetic valves. The first interface and the second interface of the first multi-way electromagnetic valves are not opened at the same time. The first interface, the second interface, the third interface and the fourth interface of the second multi-way electromagnetic valves are opened or closed at the same time. The value range of n is 4-32. The application further comprises an automatic control unit, which is connected with the first multi-way electromagnetic valves and the second multi-way electromagnetic valves and controls the opening and closing of the interfaces of the first multi-way electromagnetic valves and the second multi-way electromagnetic valves.

3. The simulated moving bed separation system of claim 1, wherein, The holding time of the different interfaces of the first multi-way electromagnetic valves is 50-4000s, and / or the holding time of the different interfaces of the second multi-way electromagnetic valves is 50-4000s. The material to be separated feeding unit comprises a first storage device, which is connected with the third interface of the second multi-way electromagnetic valves through a first conveying pump. The material to be separated feeding unit further comprises a first preheating device and / or a first metering device, the first preheating device is arranged adjacent to the third interface of the second multi-way electromagnetic valves, and the first metering device is connected with the first storage device.

4. The simulated moving bed separation system of claim 1, wherein, The flow rate of the first conveying pump is 1-20ml / min. The desorbent feeding unit comprises a second storage device, which is connected with the first interface of the second multi-way electromagnetic valves through a second conveying pump. The desorbent feeding unit further comprises a second preheating device and / or a second metering device, the second preheating device is arranged adjacent to the first interface of the second multi-way electromagnetic valves, and the second metering device is connected with the second storage device.

5. The simulated moving bed separation system of claim 1, wherein, The flow rate of the second conveying pump is 1-50ml / min. ​ ​ 6. The simulated moving bed separation system of claim 1, wherein, The extract outlet unit comprises a first cooling device and a third delivery pump connected to the second interface of the second multi-way electromagnetic valve, and the first cooling device is arranged adjacent to the inlet end of the third delivery pump. The flow rate of the third delivery pump is 1ml / min-50ml / min.

7. The simulated moving bed separation system of claim 1, wherein, The raffinate outlet unit comprises a second cooling device, the inlet of which is connected to the fourth interface of the second multi-way electromagnetic valve, and the outlet of which is connected to a back pressure valve.

8. The simulated moving bed separation system of claim 1, wherein, The desorbent circulation unit comprises a circulation pump, the inlet of which is connected to the second interface of the first multi-way electromagnetic valve through a circulation pipeline, and the outlet of which is connected to the desorbent feeding unit. The desorbent circulation unit further comprises a third cooling device arranged adjacent to the inlet end of the circulation pump. The desorbent circulation unit further comprises a one-way valve connected to the circulation pipeline and a flow meter connected to the circulation pump. The flow rate of the circulation pump is 1ml / min-100ml / min.

9. The simulated moving bed separation system of claim 1, wherein, A temperature measuring device is arranged in the adsorption column. A heating device and / or a gas flow device are arranged in the separation unit. The temperature in the adsorption column is 20-220℃. A pressure sensor and / or a safety valve are arranged at the inlet of the adsorption column. The pressure of the liquid in the adsorption column is 0.1MPa-3.0MPa.

10. The simulated moving bed separation system of claim 3, wherein, The automatic control unit is connected to at least one of the separation unit, the material to be separated feeding unit, the desorbent feeding unit, the extract outlet unit and the raffinate outlet unit, and monitors the temperature and / or pressure in the system.

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