Reagent bottle sealing method, reagent bottle sealing device, and sample analyzer

Abstract

The present invention discloses a reagent bottle sealing method, a reagent bottle sealing device and a sample analyzer. The reagent bottle sealing method includes: a driving mechanism drives a reagent needle assembly to move towards the reagent bottle, so that the reagent needle of the reagent needle assembly is inserted into the reagent bottle, and the seal of the reagent needle assembly abuts against the outer periphery of the reagent bottle body; obtaining the abutting pressure generated by the seal on the reagent bottle; when the abutting pressure is less than a preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly. The reagent bottle sealing method of the present invention can automatically seal the reagent bottle, reduce the contact area between the reagent and air during the sampling process, and can adapt to the sealing of various different reagent bottles.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a reagent bottle sealing method, a reagent bottle sealing device, and a sample analyzer. Background Art

[0002] In the in vitro diagnosis industry, in order to measure relevant clinical parameters, it is usually necessary to add different reagents to a sample for reaction before corresponding measurements. Some of these reagents contain volatile substances. For example, the latex reagent required for C-reactive protein parameter detection is a reagent containing volatile substances. To extend the open vial expiration date of the reagent, measures are usually taken to reduce the storage temperature of the reagent or reduce the contact area between the reagent and air, thereby reducing the diffusion movement of the volatile substances in the reagent and ultimately achieving the purpose of extending the open vial expiration date.

[0003] Currently, basically all manufacturers design corresponding storage modules to store the latex reagent and directly use a sampling needle to aspirate and dispense the reagent. However, when the latex reagent is stored in the reagent bin, the upper end opening of the reagent bin needs to be relatively large for the sampling needle to aspirate the sample easily, resulting in a large contact area between the reagent in the reagent bottle and air and a large amount of reagent volatilization.

[0004] In view of the above defects, it is necessary to provide a new reagent bottle sealing method, a reagent bottle sealing device, and a sample analyzer. Summary of the Invention

[0005] The main object of the present invention is to provide a reagent bottle sealing method, a reagent bottle sealing device, and a sample analyzer, aiming to solve the problem of large contact area between the existing reagent and air during the sampling process.

[0006] To achieve the above object, the reagent bottle sealing method proposed by the present invention includes:

[0007] A driving mechanism drives a reagent needle assembly to move towards the reagent bottle, so that the reagent needle of the reagent needle assembly is inserted into the reagent bottle, and a sealing member of the reagent needle assembly abuts against the outer periphery of the bottle body of the reagent bottle;

[0008] Obtain the abutting pressure generated by the sealing member on the reagent bottle;

[0009] When the abutting pressure is less than a preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly.

[0010] Preferably, the step that when the abutting pressure is less than a preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly includes:

[0011] When the abutting pressure is less than the preset pressure threshold, query the compression amount of the seal in a preset relationship table, where the preset relationship table is a mapping table of the abutting pressure and the compression amount;

[0012] Calculate the remaining running distance that the seal needs to run according to the compression amount;

[0013] Control the driving mechanism to continue to drive the reagent needle assembly to move towards the reagent bottle by the remaining running distance until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly.

[0014] Preferably, the step that the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle by the remaining running distance until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly includes:

[0015] Calculate the running speed according to the remaining running distance and a preset running time;

[0016] The driving mechanism drives the reagent needle assembly to move towards the reagent bottle by the remaining running distance at the running speed within the preset running time.

[0017] Preferably, after the step that when the abutting pressure is less than the preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly, it further includes:

[0018] Record the running distance of the reagent needle assembly.

[0019] In addition, to achieve the above object, the present invention also provides a reagent bottle sealing device, and the reagent bottle sealing device includes:

[0020] A reagent bottle accommodating device, which is provided with an accommodating cavity for placing a reagent bottle, and a pressure sensor is provided on the bottom wall of the accommodating cavity;

[0021] A reagent needle assembly, located above the reagent bottle accommodating device, includes a seal and a reagent needle. A groove for accommodating the mouth of the reagent bottle is formed by concave inward at the bottom of the seal. The outer peripheral edge of the groove opening is used to abut against the outer periphery of the bottle body of the reagent bottle, and the needle tip of the reagent needle passes through the groove wall;

[0022] A driving mechanism for driving the reagent needle assembly to move towards the reagent bottle, so that the reagent needle of the reagent needle assembly is inserted into the reagent bottle, and the seal of the reagent needle assembly abuts against the outer periphery of the bottle body of the reagent bottle;

[0023] A control module is electrically connected to the driving mechanism and the pressure sensor respectively. The pressure sensor is used to sense the abutting pressure generated by the seal on the reagent bottle and transmit a pressure signal to the control module. The control module is used to control the driving mechanism to drive the reagent needle assembly to move towards the reagent bottle when the abutting pressure is less than a preset pressure threshold, and stop driving the reagent needle assembly by the driving mechanism until the abutting pressure reaches the preset pressure threshold.

[0024] Preferably, the seal includes a flexible part and a guiding part connected to each other. The bottom of the guiding part is concaved to form the groove. The flexible part extends outward along the notch of the groove. The flexible part is provided with a flange surrounding the outer periphery of the notch. There is a step on the outer periphery of the bottle body of the reagent bottle. The flange abuts against the step, and the flange is provided with a ventilation groove communicating the groove with the outside.

[0025] Preferably, the seal includes at least two guiding parts, and the number of reagent bottles placed in the accommodating cavity is the same as and corresponds to the number of guiding parts one by one.

[0026] Preferably, the flexible part is provided with an anti-fooling notch, and one anti-fooling notch is provided between any two adjacent guiding parts.

[0027] Preferably, both ends of the flexible part are provided with protruding side edges for abutting against the side wall of the reagent bottle.

[0028] Preferably, a guiding slope is provided on one side of the protruding side edge facing the groove, and the distance between the guiding slopes on both sides of the groove gradually increases in the direction away from the groove.

[0029] Preferably, the reagent bottle sealing device includes a frame. The reagent bottle accommodating device is provided on the frame. The reagent needle assembly includes a movable seat movably connected to the frame. The seal and the reagent needle are both provided on the movable seat. The driving mechanism is used to drive the movable seat to move relative to the frame in the vertical direction.

[0030] Preferably, a fixing groove for fixing the seal is concaved at the bottom of the movable seat. A through hole and a fixing hole are sequentially formed in the top wall of the fixing groove from top to bottom. The top of the reagent needle is fixed in the fixing hole, and the reagent needle is communicated with an external pipeline through the through hole.

[0031] Preferably, the driving mechanism includes a driving member, a synchronous belt and two synchronous pulleys. The two synchronous pulleys are arranged on the frame in the up-and-down direction. The synchronous belt is wound around the outer circumferences of the two synchronous pulleys. The movable seat is connected to one side of the synchronous belt. The driving member is fixed on the frame, and the driving member is used to drive one of the synchronous pulleys to rotate and drive the movable seat to lift relative to the frame through the synchronous belt.

[0032] Preferably, a guiding member extending in the up-and-down direction is provided on the frame, and a guiding hole cooperating with the guiding member is provided on the movable seat; and / or, a rotation limiting member extending in the up-and-down direction is provided on the frame, and a limiting sliding groove slidably cooperating with the rotation limiting member is provided on the movable seat.

[0033] Preferably, a position sensor is provided on the frame, and a sensing piece for the position sensor to sense is provided on the movable seat.

[0034] In addition, to achieve the above object, the present invention further provides a sample analyzer, which includes a reaction cell and the reagent bottle sealing device as described above. The reagent needle assembly includes a pipeline communicated with the reagent needle, and the outlet end of the pipeline is communicated with the reaction cell.

[0035] In the technical solution of the present invention, a pressure sensor is provided on the bottom wall of the accommodation cavity to detect the pressure of the reagent bottle exerted by the sealing member in the up-and-down direction. When the motor drives the sealing member to contact the reagent bottle, the pressure sensor can sense the pressure change and feedback the signal to the control module. The control module can perform corresponding actions according to the magnitude of the pressure signal. When the abutting pressure is less than the preset pressure threshold, the control motor continues to drive the reagent needle assembly to move in the direction close to the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly. Among them, the preset pressure threshold is the preset value of the best state of pressing the sealing member and the reagent bottle. When replacing the reagent bottle, this process will automatically repeat the debugging, and then determine the new control parameters. The reagent bottle sealing method of the present invention can automatically seal the reagent bottle, reduce the contact area between the reagent and the air during the sampling process, and can adapt to the sealing of various different reagent bottles. Description of the Drawings

[0036] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on the structures shown in these drawings.

[0037] Figure 1Schematic flowchart of the reagent bottle sealing method in an embodiment of the present invention;

[0038] Figure 2 Schematic structural diagram of a reagent bottle sealing device from one angle in an embodiment of the present invention;

[0039] Figure 3 Schematic structural diagram of a reagent bottle sealing device from another angle in an embodiment of the present invention;

[0040] Figure 4 Schematic cross-sectional diagram of a reagent bottle sealing device in an embodiment of the present invention;

[0041] Figure 5 Another schematic cross-sectional diagram of a reagent bottle sealing device in an embodiment of the present invention;

[0042] Figure 6 Schematic structural diagram of a seal in an embodiment of the present invention;

[0043] Figure 7 Schematic structural diagram of a reagent bottle in an embodiment of the present invention.

[0044] Explanation of the reference numerals in the drawings:

[0045] Label Name Label Name 1 Frame 3221 Flange 11 Guide 3222 Vent groove 12 Rotation limiting part 3223 Anti-fooling notch 13 Position sensor 3224 Protruding side edge 2 Reagent bottle accommodating device 3225 Guide ramp 21 Accommodating cavity 323 Guide part 22 Pressure sensor 33 Reagent needle 3 Reagent needle assembly 4 Drive mechanism 31 Movable seat 41 Driver 311 Fixed groove 42 Synchronous pulley 3111 Through hole 43 Synchronous belt 312 Sensing piece 10 Reagent bottle 32 Seal 101 Bottle mouth 321 Groove 102 Bottle body 322 Flexible part 103 Step

[0046] The realization of the object, functional features and advantages of the present invention will be further described with reference to the embodiments and the accompanying drawings. Detailed implementation manners

[0047] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts shall fall within the protection scope of the present invention.

[0048] It should be noted that all directional indications (such as up, down, left, right, front, back...) in the embodiments of the present invention are only used to explain the relative positional relationship and movement conditions between components in a specific posture (as shown in the drawings). If the specific posture changes, the directional indications will also change accordingly.

[0049] In addition, in the present invention, descriptions such as "first", "second", etc. are only for descriptive purposes and should not be construed as indicating or implying their relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first", "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, the meaning of "a plurality" is at least two, such as two, three, etc., unless otherwise specifically defined.

[0050] In the present invention, unless otherwise clearly specified and limited, terms such as "connection", "fixation", etc. should be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and can be the communication inside two components or the interaction relationship between two components, unless otherwise clearly limited. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0051] In addition, the technical solutions between various embodiments of the present invention can be combined with each other, but it must be based on the ability of those of ordinary skill in the art to implement. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the protection scope required by the present invention.

[0052] The present invention provides a reagent bottle sealing method, a reagent bottle sealing device and a sample analyzer, aiming to solve the problem that the existing reagent has a large contact area with air during the sampling process.

[0053] Please refer to Figure 1 , the reagent bottle sealing method includes:

[0054] S01. The driving mechanism drives the reagent needle assembly to move towards the reagent bottle, so that the reagent needle of the reagent needle assembly is inserted into the reagent bottle, and the seal of the reagent needle assembly abuts against the outer periphery of the bottle body of the reagent bottle;

[0055] S02. Obtain the abutting pressure generated by the seal on the reagent bottle;

[0056] S03. When the abutting pressure is less than the preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly.

[0057] The reagent bottle sealing method of the present invention is as follows: A pressure sensor is provided on the bottom wall of the accommodation cavity to detect the magnitude of the pressure exerted by the sealing member on the reagent bottle in the up and down directions. When the motor drives the sealing member to contact the reagent bottle, the pressure sensor can sense the pressure change and feedback the signal to the control module. The control module can perform corresponding actions according to the magnitude of the pressure signal. When the abutting pressure is less than the preset pressure threshold, the control motor continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly. Among them, the preset pressure threshold is the preset value for the best state of pressing between the sealing member and the reagent bottle. When replacing the reagent bottle, this process will automatically repeat the debugging and then determine the new control parameters. The reagent bottle sealing method of the present invention can automatically seal the reagent bottle, reduce the contact area between the reagent and air during the sampling process, and can adapt to the sealing of various different reagent bottles.

[0058] Among them, as Figure 2 shown, in one embodiment, the steps of S03 include:

[0059] When the abutting pressure is less than the preset pressure threshold, query the compression amount of the sealing member in the preset relationship table according to the abutting pressure. The preset relationship table is a mapping table of the abutting pressure and the compression amount;

[0060] Calculate the remaining running distance required for the sealing member to run according to the compression amount;

[0061] Control the driving mechanism to continue driving the reagent needle assembly to move towards the reagent bottle by the remaining running distance until the abutting pressure reaches the preset pressure threshold and stop driving the reagent needle assembly.

[0062] A relationship table of the pressure value and the compression amount of the sealing member is preset in the control module. When the motor drives the sealing member to contact the reagent bottle, the pressure sensor can sense the pressure change and feedback the signal to the control module. The control module can obtain the remaining running distance to be run from the preset table according to the magnitude of the pressure signal, and then control the motor to continue driving the reagent needle assembly to move towards the reagent bottle by the remaining running distance until the pressure value reaches the preset value for the best state of pressing between the sealing member and the reagent bottle, and then control the motor to stop moving.

[0063] Further, the step of controlling the driving mechanism to continue driving the reagent needle assembly to move towards the reagent bottle by the remaining running distance until the abutting pressure reaches the preset pressure threshold and stop driving the reagent needle assembly includes:

[0064] Calculate the running speed according to the remaining running distance and the preset running time;

[0065] The driving mechanism drives the reagent needle assembly to move the remaining running distance in the direction close to the reagent bottle at the running speed within the preset running time.

[0066] When the motor drives the seal to contact the reagent bottle, the pressure sensor can sense the pressure change and feedback the signal to the control module. The control module can obtain the remaining running distance to be run from the preset table according to the magnitude of the pressure signal, and then control the movement speed of the motor, so that the motor drives the reagent needle assembly to move the remaining running distance in the direction close to the reagent bottle at the running speed.

[0067] In addition, in an embodiment, after the step of S03, it further includes:

[0068] Record the running distance of the reagent needle assembly.

[0069] When the pressure value reaches the preset value in the best state of pressing between the seal and the reagent bottle, the control module controls the motor to stop moving. At this time, record the total stroke of the motor from the initial position of the optocoupler to the stop state, and use this total stroke as the control parameter when using the current reagent bottle. When replacing the reagent bottle, this process will automatically repeat the debugging, and then determine the new control parameter.

[0070] In addition, please refer to Figures 2 to 7 As shown, the present invention also provides a reagent bottle sealing device, which includes a reagent bottle accommodating device 2, a reagent needle assembly 3, a driving mechanism 4 and a control module. The reagent bottle accommodating device 2 is provided with an accommodating cavity 21 for placing the reagent bottle 10. The bottom wall of the accommodating cavity 21 is provided with a pressure sensor 22. The reagent needle assembly 3 is located above the reagent bottle accommodating device 2 and includes a seal 32 and a reagent needle 33. The bottom of the seal 32 is concavely formed with a groove 321 for accommodating the mouth 101 of the reagent bottle 10. The edge of the groove 321 is used to abut against the outer circumference of the bottle body 102 of the reagent bottle 10. The needle of the reagent needle 33 passes through the wall of the groove 321. The driving mechanism 4 is used to drive the reagent needle assembly 3 to move in the direction close to the reagent bottle 10, so that the reagent needle 33 of the reagent needle assembly 3 is inserted into the reagent bottle 10, and the seal 32 of the reagent needle assembly 3 abuts against the outer circumference of the bottle body 102 of the reagent bottle 10. The control module is electrically connected to the driving mechanism 4 and the pressure sensor 22 respectively. The pressure sensor 22 is used to sense the abutting pressure generated by the seal 32 on the reagent bottle 10 and transmit the pressure signal to the control module. The control module is used to control the driving mechanism 4 to drive the reagent needle assembly 3 to move in the direction close to the reagent bottle 10 when the abutting pressure is less than the preset pressure threshold, until the abutting pressure reaches the preset pressure threshold, and then control the driving mechanism 4 to stop driving the reagent needle assembly 3.

[0071] In the reagent bottle sealing device of the present invention, the reagent bottle 10 is placed in the accommodating cavity 21 of the reagent bottle accommodating device 2. The reagent bottle accommodating device 2 provides the required storage temperature for the reagent. The reagent needle assembly 3 is provided with corresponding sampling needles and pipelines. Under the action of a fluid power source and a valve, the reagent can be aspirated from the reagent bottle 10 through the pipelines and sampling needles and distributed to corresponding reaction pools or measurement pools. Among them, the sampling needle is driven by a driving mechanism 4 and can move up and down to disengage from or insert into the reagent bottle 10. When the reagent is used up and needs to be replaced, the reagent needle 33 disengages from the reagent bottle 10 under the action of the driving mechanism 4, facilitating the replacement of the reagent. When the driving mechanism 4 drives the reagent needle 33 to move downward, the seal 32 on the reagent needle assembly 3 seals the mouth of the reagent bottle 10 when it fits against the reagent bottle 10, that is, the outer peripheral edge of the notch of the groove 321 is used to abut against the outer periphery of the bottle body 102 of the reagent bottle 10, and the seal 32 does not contact the bottle mouth 101 of the reagent bottle 10, which can effectively ensure the cleanliness of the seal 32, ensure that reagents of different batches do not affect each other, can seal the reagent bottle 10 well, cut off the contact between the reagent in the reagent bottle 10 and the outside air, isolate the convection with the ambient air, and reduce the molecular diffusion movement of volatile substances in the reagent, thereby reducing the contact area between the reagent and the air during the sampling process.

[0072] In addition, the seal 32 can be made of silicone or other soft materials. The seal 32 is connected to the movable seat 31, or a connecting member of the seal 32 can be additionally provided and connected to the movable seat 31 through the connecting member. The seal 32 is sleeved and assembled in the movable seat 31 in an interference fit manner, or can also be injection molded on the movable seat 31 by an injection molding method. The reagent needle 33 is connected to the movable seat 31, and the up and down linear movement of the movable seat 31 drives the seal 32 to move up and down while also driving the reagent needle 33 to move up and down.

[0073] Among them, the seal 32 includes a flexible part 322 and a guiding part 323 connected to each other. The bottom of the guiding part 323 is concave to form a groove 321. The flexible part 322 extends outward along the notch of the groove 321. The flexible part 322 is provided with a flange 3221 surrounding the outer periphery of the notch. The outer periphery of the bottle body 102 of the reagent bottle 10 is provided with a step 103. The flange 3221 abuts against the step 103, and the flange 3221 is provided with a ventilation groove 3222 communicating the groove 321 with the outside.

[0074] The flange 3221 of the seal 32 is in close contact with the surface of the step 103 between the mouth of the reagent bottle 10 and the bottle body 102, forming a relatively airtight space, isolating the mouth 101 of the reagent bottle 10 from the outside air, reducing the area of air flow between the mouth 101 and the atmosphere, and reducing the reagent volatilization rate. Among them, due to the uncertainty of the reagent transportation environment, the upper end face of the mouth 101 of the reagent bottle 10 will come into contact with the reagent. It is necessary to design the corresponding size of the seal 32 according to the height and diameter dimensions of the mouth 101 of the reagent bottle 10 to ensure that there is a certain gap between the seal 32 and the upper end face of the mouth 101 in the axial direction, ensuring that the seal 32 does not contact the upper end face of the mouth 101 of the reagent bottle 10. The beneficial effect of this is to ensure that the seal 32 will not be contaminated by the reagent on the end face of the mouth of the reagent bottle 10, thus avoiding reagent crystallization after multiple contaminations and falling into reagents of different batches, thereby affecting the performance of the reagent.

[0075] Among them, the flange 3221 of the seal 32 mainly forms a seal by fitting with the side arc surface of the reagent bottle 10, the side arc surface, the step 103 surface of the reagent bottle 10, and the step 103 surface of the reagent bottle 10. When the structure of the reagent bottle 10 is different, the structure of the silicone seal 32 changes accordingly. The seal 32 can also fit and seal the periphery of the bottle body 102, and the same effect can be achieved. In short, it is to perform an enclosing seal around the mouth of the reagent bottle 10 without directly sealing the end face of the mouth 101. When the reagent needle assembly 3 drives the seal 32 to move downward and close to the reagent bottle 10, under the action of the same compression amount, the contact surface between the seal 32 and the reagent bottle 10 is small, reducing the pressure on the reagent bottle 10. Secondly, a groove 321 or a flange 3221 can also be provided on the step 103 surface or the arc surface at the transition between the mouth 101 and the bottle body 102 of the reagent bottle 10, or on the circumference of the mouth 101 or the circumference of the bottle body 102, and then cooperate with the flange 3221 or the groove 321 of the silicone seal 32 for fitting and sealing.

[0076] The flange 3221 is provided with a ventilation groove 3222 that connects the groove 321 to the outside. When the seal 32 is pressed and fitted with the mouth of the reagent bottle 10, since the fitting acts through the flange 3221, the ventilation groove 3222 retains a very small path connecting to the outside, ensuring that the pressure inside the reagent bottle 10 is the same as the external environment pressure, so as to ensure that the reagent can be smoothly sucked out. The structure of the ventilation groove 3222 is not limited to the specific structure in this scheme, as long as it can connect the inside of the reagent to the external environment passage.

[0077] Further, in order to achieve multiple functions, the seal 32 includes at least two guiding portions 323, and the number of reagent bottles 10 placed in the accommodating cavity 21 is the same as and corresponds one-to-one with the number of guiding portions 323. The reagent bottle 10 can be a single one or at least two, and the shape of the reagent bottle 10 has no special limitation, as long as it is ensured that the bottle body 102 is larger than the bottle mouth 101. By arranging at least two reagent bottles 10 in the reagent bottle accommodating device 2 and providing guiding portions 323 corresponding to the reagent bottles 10, the efficiency of taking reagents can be increased, and each reagent bottle 10 in the reagent bottle accommodating device 2 can be sealed.

[0078] In addition, in the above embodiment, the flexible portion 322 is provided with a foolproof notch 3223, and a foolproof notch 3223 is provided between any two adjacent guiding portions 323. The foolproof notch 3223 ensures that the direction of assembling the seal 32 into the movable seat 31 is correct, improves the assembly efficiency, and reduces assembly errors.

[0079] In one embodiment, convex side edges 3224 are provided at both ends of the flexible portion 322, and the convex side edges 3224 are used to abut against the side wall of the reagent bottle 10. A convex side edge 3224 is provided at each of the two ends of the flexible portion 322. When the reagent bottle 10 needs to be sealed, the reagent bottle 10 can be limited, ensuring that the seal 32 can tightly press the reagent bottle 10 in the middle.

[0080] Further, a guiding slope 3225 is provided on the side of the convex side edge 3224 facing the groove 321, and the distance between the guiding slopes 3225 on both sides of the groove 321 gradually increases in a direction away from the groove 321. A guiding slope 3225 is provided on the side of the convex side edge 3224 facing the groove 321. When the seal 32 is covered on the reagent bottle 10, the guiding slope 3225 contacts the bottle body 102 of the reagent bottle 10, thus facilitating the seal 32 to seal the reagent bottle 10.

[0081] In addition, in one embodiment, the two convex side edges 3224 between any two adjacent grooves 321 are connected to each other. To improve the structural performance of the seal 32, the two convex side edges 3224 between any two adjacent grooves 321 can be connected to each other.

[0082] In another embodiment, between any two adjacent grooves 321, the distance between the guiding slopes 3225 of the two convex side edges 3224 gradually increases from one side of the seal 32 to the other side. To facilitate the placement of the reagent bottle 10 into the accommodating cavity 21 and its removal from the accommodating cavity 21, a space for the picking and placing manipulator to extend into can be provided between two adjacent reagent bottles 10. Moreover, to prevent the wrong placement of the reagent bottle 10, the space can be formed into a triangular cross-section, and the distance between the guiding slopes 3225 of the two corresponding convex side edges 3224 gradually increases from one side of the seal 32 to the other side.

[0083] Furthermore, the reagent bottle sealing device includes a frame 1, a reagent bottle accommodating device 2 is provided on the frame 1, the reagent needle assembly 3 includes a movable seat 31 movably connected to the frame 1, a sealing member 32 and a reagent needle 33 are both provided on the movable seat 31, and a driving mechanism 4 is used to drive the movable seat 31 to move relative to the frame 1 in the up and down direction. The sealing member 32 and the reagent needle 33 are both provided on the movable seat 31, so that by driving the movable seat 31 to move relative to the frame 1 in the up and down direction by the driving mechanism 4, the sealing member 32 and the reagent needle 33 are driven to approach or move away from the reagent bottle 10 in the up and down direction, saving driving resources.

[0084] Wherein, the bottom of the movable seat 31 is recessed to form a fixing groove 311 for fixing the sealing member 32. The top wall of the fixing groove 311 is sequentially provided with a through hole 3111 and a fixing hole from top to bottom. The top of the reagent needle 33 is fixed in the fixing hole, and the reagent needle 33 is communicated with the external pipeline through the through hole 3111. To ensure the fixation of the sealing member 32, a fixing groove 311 can be provided at the bottom of the movable seat 31. The guiding portion 323 of the sealing member 32 is fixed in the fixing groove 311. An opening for the reagent needle 33 to pass through is provided on the groove wall of the groove 321. A fixing hole and a through hole 3111 are provided on the groove wall of the fixing groove 311. One end of the reagent needle 33 exposed from the opening is fixed in the fixing hole and communicated with the through hole 3111.

[0085] In addition, in the above embodiment, the driving mechanism 4 includes a driving member 41, a synchronous belt 43 and two synchronous pulleys 42. The two synchronous pulleys 42 are arranged on the frame 1 in the up and down direction. The synchronous belt 43 is wound around the outer peripheries of the two synchronous pulleys 42. The movable seat 31 is connected to one side of the synchronous belt. The driving member 41 is fixed on the frame 1, and the driving member 41 is used to drive one of the synchronous pulleys 42 to rotate and drive the movable seat 31 to lift relative to the frame 1 through the synchronous belt 43. The driving member 41 can be a driving motor. The driving motor is fixedly installed on the frame 1. The driving motor drives the movable seat 31 to perform a linear motion up and down through the synchronous belt 43. The movable seat 31 and the synchronous belt 43 are tightly connected by a pressing plate. It should be noted that the driving component of the reagent needle 33 can be a synchronous belt 43 drive, or any other mechanism or module that can achieve a reciprocating linear motion.

[0086] Furthermore, in one embodiment, a guiding member 11 extending in the up and down direction is provided on the frame 1, and a guiding hole cooperating with the guiding member 11 is provided on the movable seat 31. Among them, the guiding member 11 plays a guiding role and limits the linear motion of the sampling needle in a preset plane perpendicular to the axis of the guiding member 11.

[0087] In another embodiment, a rotation limiting member 12 extending in the vertical direction is provided on the frame 1, and a limiting chute that slidably cooperates with the rotation limiting member 12 is provided on the movable seat 31. By cooperating with the limiting chute on the movable seat 31, the rotation limiting member 12 restricts the axial rotation of the sampling needle along the guide member 11 when the sampling needle moves up and down, thereby ensuring the linear movement of the sampling needle in the vertical direction, ensuring that the sampling needle accurately extends into and disengages from the reagent bottle 10, and ensuring that the fitting position of the seal 32 and the reagent bottle 10 in the horizontal plane is unique.

[0088] In addition, a position sensor 13 is provided on the frame 1, and a sensing piece 312 for the position sensor 13 to sense is provided on the movable seat 31. The pressure sensor 22 provided at the bottom of the reagent bottle 10 automatically detects the pressing force of the seal 32 on the reagent bottle 10 and feeds it back to the control system, thereby controlling the movement speed and distance of the motor, and automatically eliminating the problem of poor sealing fit caused by assembly and the height error of the reagent bottle 10. The position of the silicone seal 32 moving up and down can be accurately controlled by debugging the compensation parameters of the position sensor 13, so as to ensure the precise fit of the flange 3221 of the silicone seal 32 and the reagent bottle 10 and eliminate the error caused by assembly. Specifically, the position sensor 13 can adopt an optocoupler sensor, which is fixed at the upper end of the frame 1 of the reagent needle assembly 3, and the sensing piece 312, that is, the optocoupler baffle, is fixed on the movable seat 31. The movable seat 31 is fixed on the synchronous belt 43 through a pressing plate and can perform linear movement up and down driven by the motor.

[0089] In addition, the present invention also provides a sample analyzer, which includes a reaction cell and the reagent bottle sealing device as described above. The specific structure of the reagent bottle sealing device in this sample analyzer refers to the above embodiments. Since this sample analyzer adopts all the technical solutions of the above embodiments, it at least has all the beneficial effects brought by the technical solutions of the above embodiments, and will not be elaborated here one by one.

[0090] The above are only the preferred embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent structural transformation made by using the content of the specification and drawings of the present invention under the inventive concept of the present invention, or direct / indirect application in other related technical fields, is included in the patent protection scope of the present invention.

Claims

1. A reagent bottle sealing method, characterized in that, Including: A driving mechanism drives a reagent needle assembly to move towards the reagent bottle, so that the reagent needle of the reagent needle assembly is inserted into the reagent bottle, and the seal of the reagent needle assembly abuts against the outer periphery of the bottle body of the reagent bottle; Obtain the abutting pressure generated by the seal on the reagent bottle; When the abutting pressure is less than a preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly; The step that when the abutting pressure is less than a preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly includes: When the abutting pressure is less than a preset pressure threshold, query the compression amount of the seal in a preset relationship table, and the preset relationship table is a mapping table of the abutting pressure and the compression amount; Calculate the remaining running distance required for the seal to run according to the compression amount; Control the driving mechanism to continue to drive the reagent needle assembly to move towards the reagent bottle by the remaining running distance until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly.

2. The reagent bottle sealing method according to claim 1, wherein The step that controls the driving mechanism to continue to drive the reagent needle assembly to move towards the reagent bottle by the remaining running distance until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly includes: Calculate the running speed according to the remaining running distance and a preset running time; The driving mechanism drives the reagent needle assembly to move towards the reagent bottle by the remaining running distance at the running speed within a preset running time.

3. The reagent bottle sealing method according to claim 2, characterized in that, After the step that when the abutting pressure is less than a preset pressure threshold, the driving mechanism continues to drive the reagent needle assembly to move towards the reagent bottle until the abutting pressure reaches the preset pressure threshold and stops driving the reagent needle assembly, it further includes: Record the running distance of the reagent needle assembly.

4. A reagent bottle sealing device, characterized in that, Including: A reagent bottle accommodating device, provided with an accommodating cavity for placing a reagent bottle, and a pressure sensor is provided on the bottom wall of the accommodating cavity; A reagent needle assembly, located above the reagent bottle accommodating device, includes a seal and a reagent needle. The bottom of the seal is concavely formed with a groove for accommodating the bottle mouth of the reagent bottle, and the outer peripheral edge of the groove opening is used to abut against the outer periphery of the bottle body of the reagent bottle, and the needle tip of the reagent needle passes through the groove wall; A driving mechanism, used to drive the reagent needle assembly to move towards the reagent bottle, so that the reagent needle of the reagent needle assembly is inserted into the reagent bottle, and the seal of the reagent needle assembly abuts against the outer periphery of the bottle body of the reagent bottle; A control module is electrically connected to the driving mechanism and the pressure sensor respectively. The pressure sensor is used to sense the abutting pressure generated by the seal on the reagent bottle and transmit a pressure signal to the control module. The control module is used to control the driving mechanism to drive the reagent needle assembly to move towards the reagent bottle when the abutting pressure is less than a preset pressure threshold, and stop driving the reagent needle assembly until the abutting pressure reaches the preset pressure threshold.

5. The reagent bottle sealing device according to claim 4, characterized in that, The seal includes a flexible part and a guiding part connected to each other. The bottom of the guiding part is recessed to form the groove. The flexible part extends outward along the notch of the groove. The flexible part is provided with a flange surrounding the outer periphery of the notch. A step is provided on the outer periphery of the bottle body of the reagent bottle. The flange abuts against the step, and the flange is provided with a ventilation groove communicating the groove with the outside.

6. The reagent bottle sealing device according to claim 5, characterized in that, The seal includes at least two of the guiding parts. The number of reagent bottles placed in the accommodating cavity is the same as and corresponds one by one to the number of the guiding parts.

7. The reagent bottle sealing device according to claim 5, characterized in that, The flexible part is provided with anti-fooling notches, and one anti-fooling notch is provided between any two adjacent guiding parts.

8. The reagent bottle sealing device according to claim 5, wherein, Both ends of the flexible part are provided with protruding side edges for abutting against the side wall of the reagent bottle.

9. The reagent bottle sealing device according to claim 8, characterized in that, A guiding slope is provided on one side of the protruding side edge facing the groove. The distance between the guiding slopes on both sides of the groove gradually increases in a direction away from the groove.

10. The reagent bottle sealing device according to any one of claims 4 to 9, characterized in that, The reagent bottle sealing device includes a frame. The reagent bottle accommodating device is provided on the frame. The reagent needle assembly includes a movable seat movably connected to the frame. The seal and the reagent needle are both provided on the movable seat. The driving mechanism is used to drive the movable seat to move relative to the frame in the up and down direction.

11. The reagent bottle sealing device according to claim 10, characterized in that, The bottom of the movable seat is recessed to form a fixing groove for fixing the seal. A through hole and a fixing hole are sequentially provided on the top wall of the fixing groove from top to bottom. The top of the reagent needle is fixed in the fixing hole, and the reagent needle is communicated with an external pipeline through the through hole.

12. The reagent bottle sealing device according to claim 10, wherein, The driving mechanism includes a driving member, a synchronous belt and two synchronous wheels. The two synchronous wheels are arranged on the frame in the up and down direction. The synchronous belt is wound around the outer peripheries of the two synchronous wheels. One side of the movable seat is connected to the synchronous belt. The driving member is fixed on the frame, and the driving member is used to drive one of the synchronous wheels to rotate and drive the movable seat to lift relative to the frame through the synchronous belt.

13. The reagent bottle sealing device according to claim 10, characterized in that, A guiding member extending in the up and down direction is provided on the frame. A guiding hole cooperating with the guiding member is provided on the movable seat; and / or A rotation limiting member extending in the up and down direction is provided on the frame. A limiting sliding groove slidably cooperating with the rotation limiting member is provided on the movable seat.

14. The reagent bottle sealing device according to claim 10, wherein A position sensor is provided on the frame. A sensing piece for the position sensor to sense is provided on the movable seat.

15. A sample analyzer, characterized in that, The sample analyzer includes a reaction cell and a reagent bottle sealing device as described in any one of claims 4 to 14. The reagent needle assembly includes a pipeline communicating with the reagent needle, and the outlet end of the pipeline communicates with the reaction cell.

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