A wound healing patch containing aloe vera gel

Abstract

This invention relates to the field of wound repair technology, and in particular to a wound repair patch containing aloe vera gel. By weight, the raw materials of the wound dressing containing aloe vera gel include: 20-25 parts aloe vera gel, 7-10 parts chitosan, 100 parts polyvinyl alcohol, and 8-12 parts white tea extract. Aloe vera gel has certain anti-inflammatory and antibacterial properties, promotes local metabolism, astringes wounds, and promotes cell regeneration. The wound dressing prepared by electrospinning has good breathability and can effectively absorb exudate from the wound, creating a relatively dry environment. However, an overly dry environment is not conducive to the repair and reconstruction of skin tissue. The amino acids and complex polysaccharides contained in the aloe vera gel in the dressing constitute natural moisturizing factors, which can replenish the lost moisture in the skin, quickly restore the function of skin collagen, and promote wound healing.

Description

Technical Field

[0001] This invention relates to the field of wound repair technology, and in particular to a wound repair patch containing aloe vera gel. Background Technology

[0002] Wound healing patches (adhesive bandages) are a commonly used medical product that helps stop bleeding from skin wounds and prevent further injury. While current adhesive bandages can suppress bleeding from skin wounds, their breathability and anti-inflammatory effects are poor. Bacteria can easily grow in the sealed, warm, and humid environment, slowing down wound healing and, in severe cases, potentially causing inflammation and suppuration, resulting in a poor user experience. Summary of the Invention

[0003] The purpose of this invention is to provide a wound repair patch containing aloe vera gel to solve the problems existing in the prior art, improve the breathability and antibacterial and anti-inflammatory effects of the wound repair patch, and accelerate the recovery of skin wounds.

[0004] To achieve the above objectives, the present invention provides the following solution:

[0005] One of the technical solutions of the present invention is a wound dressing containing aloe vera gel, wherein the raw materials include, by weight parts: 20-25 parts aloe vera gel, 7-10 parts chitosan, 100 parts polyvinyl alcohol, and 8-12 parts white tea extract.

[0006] Furthermore, the molecular weight of chitosan is 8-15 kDa.

[0007] Furthermore, the preparation method of the white tea extract includes the following steps:

[0008] White tea is crushed and sieved to obtain tea powder;

[0009] After mixing tea powder and extraction solvent at a solid-liquid ratio of 1:15-20, ultrasonic extraction is performed, and the resulting filtrate is concentrated under reduced pressure to 1 / 15-1 / 20 of its original volume to obtain the white tea extract.

[0010] Furthermore, the extraction solvent is a 5% aqueous solution of acetic acid; the ultrasonic extraction temperature is 50-60℃.

[0011] The second technical solution of the present invention is a method for preparing the above-mentioned wound dressing containing aloe vera gel, comprising the following steps:

[0012] After the raw materials are mixed evenly according to the mass fractions, electrospinning is performed to obtain the wound dressing containing aloe vera gel.

[0013] Furthermore, the electrospinning rate is 0.8-1.1 mL / h, the voltage is 3-4.5 kV, and the spacing is 14.5-15.5 cm.

[0014] The third technical solution of the present invention is a wound repair patch containing aloe vera gel, wherein the effective ingredient is the above-mentioned wound dressing containing aloe vera gel.

[0015] Furthermore, the wound repair patch containing aloe vera gel also includes a breathable film, hot-air nonwoven fabric, release paper, and adhesive.

[0016] The present invention discloses the following technical effects:

[0017] Aloe vera gel has certain anti-inflammatory and antibacterial properties, promotes local metabolism, astringes wounds, and promotes cell regeneration. The phenolic acids and flavonoids in white tea extract endow it with antibacterial, antioxidant, and tissue-regenerating effects. The combined effect of white tea extract and aloe vera gel can accelerate the healing of skin wounds.

[0018] Wound dressings prepared using electrospinning are highly breathable and can effectively absorb exudate from the wound, creating a relatively dry environment. However, an overly dry environment is not conducive to the repair and reconstruction of skin tissue. The aloe vera gel in the dressing contains amino acids and complex polysaccharides, which constitute natural moisturizing factors that can replenish lost moisture in the skin, quickly restore the function of skin collagen, and promote wound healing.

[0019] The wound dressing (or plaster) containing aloe vera gel prepared by this invention has good breathability, which can provide a relatively dry environment for skin wounds, while also having certain moisturizing and breathable properties, which is beneficial to the recovery of skin wounds.

[0020] The raw materials used in this invention are readily available and inexpensive. All components of the prepared wound dressing containing aloe vera gel are biodegradable, making it natural, green, and environmentally friendly. Detailed Implementation

[0021] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0022] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range, as well as each smaller range between any other stated value or intermediate value within said range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0023] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0024] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be readily apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0025] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0026] Unless otherwise specified, all parts mentioned in the embodiments of this invention are calculated by mass.

[0027] Unless otherwise specified, all raw materials used in the embodiments of this invention can be obtained through purchase.

[0028] This invention provides a wound dressing containing aloe vera gel, the raw materials of which, by weight, include: 20-25 parts aloe vera gel, 7-10 parts chitosan, 100 parts polyvinyl alcohol, and 8-12 parts white tea extract.

[0029] In this invention, the molecular weight of chitosan is 8-15 kDa.

[0030] In this invention, the preparation method of the white tea extract includes the following steps:

[0031] White tea is pulverized and passed through a 60-80 mesh sieve to obtain tea powder;

[0032] After mixing tea powder and extraction solvent at a solid-liquid ratio of 1:15-20, ultrasonic extraction is performed, and the resulting filtrate is concentrated under reduced pressure to 1 / 15-1 / 20 of its original volume to obtain the white tea extract.

[0033] In this invention, the white tea used to prepare the white tea extract is White Peony. When using the higher-grade Silver Needle, the wound healing effect is not as good as that of White Peony. This may be because the content of amino acids, aldehydes, esters, and the total amount of volatile substances in White Peony are all higher than those in Silver Needle.

[0034] In this invention, the extraction solvent is a 5% aqueous solution of acetic acid; the ultrasonic extraction temperature is 50-60℃.

[0035] The present invention also provides a method for preparing the above-mentioned wound dressing containing aloe vera gel, comprising the following steps:

[0036] After the raw materials are mixed evenly according to the mass fractions, electrospinning is performed to obtain the wound dressing containing aloe vera gel.

[0037] In this invention, the electrospinning rate is 0.8-1.1 mL / h, the voltage is 3-4.5 kV, and the spacing is 14.5-15.5 cm.

[0038] The present invention also provides a wound repair patch containing aloe vera gel, comprising the above-mentioned wound dressing containing aloe vera gel.

[0039] In this invention, the wound repair patch containing aloe vera gel also includes a breathable film, hot air nonwoven fabric, release paper, and adhesive.

[0040] The aloe vera gel used in this embodiment of the invention was purchased from Xi'an Shouhe Biotechnology Co., Ltd., with a purity of not less than 99.5%, and is a white viscous liquid.

[0041] The chitosan used in this embodiment of the invention has a molecular weight of 10 kDa and a degree of deacetylation of 97%.

[0042] The extraction method of white tea extract used in this embodiment of the invention is as follows: white tea (white peony) is pulverized and passed through an 80-mesh sieve to obtain tea powder; the tea powder and extraction solvent (5% acetic acid aqueous solution) are mixed at a solid-liquid ratio of 1:15, and ultrasonic extraction is performed. The resulting filtrate is concentrated under reduced pressure to 1 / 15 of its original volume to obtain the white tea extract.

[0043] Example 1

[0044] Step 1, accurately weigh the raw materials: 20 parts aloe vera gel, 7 parts chitosan, 100 parts polyvinyl alcohol, and 12 parts white tea extract.

[0045] Step 2: After mixing the above raw materials evenly, perform electrospinning (speed 1mL / h, voltage 4kV, spacing 15cm) to obtain a wound dressing containing aloe vera gel.

[0046] Example 2

[0047] Step 1, accurately weigh the raw materials: 22 parts aloe vera gel, 8 parts chitosan, 100 parts polyvinyl alcohol, and 10 parts white tea extract.

[0048] Step 2: After mixing the above raw materials evenly, perform electrospinning (speed 1mL / h, voltage 4kV, spacing 15cm) to obtain a wound dressing containing aloe vera gel.

[0049] Example 3

[0050] Step 1, accurately weigh the raw materials: 25 parts aloe vera gel, 10 parts chitosan, 100 parts polyvinyl alcohol, and 8 parts white tea extract.

[0051] Step 2: After mixing the above raw materials evenly, perform electrospinning (speed 1mL / h, voltage 4kV, spacing 15cm) to obtain a wound dressing containing aloe vera gel.

[0052] Example 4

[0053] Step 1, accurately weigh the raw materials: 32 parts aloe vera gel, 7-10 parts chitosan, and 100 parts polyvinyl alcohol.

[0054] Step 2: After mixing the above raw materials evenly, perform electrospinning (speed 1mL / h, voltage 4kV, spacing 15cm) to obtain a wound dressing containing aloe vera gel.

[0055] Example 5

[0056] Step 1: Accurately weigh the raw materials: 7-10 parts chitosan, 100 parts polyvinyl alcohol, and 32 parts white tea extract.

[0057] Step 2: After mixing the above raw materials evenly, perform electrospinning (speed 1mL / h, voltage 4kV, spacing 15cm) to obtain wound dressing.

[0058] The efficacy of the wound dressings containing aloe vera gel prepared in Examples 1-5 was verified as follows:

[0059] 1. Establishment of a mouse full-thickness skin wound model: Sixty healthy mice were selected, and circular full-thickness skin wound models with a diameter of 8 mm were created on the backs of the mice. The mice were divided into 6 groups, one of which served as a blank control group, receiving no medication except for daily cleaning with hydrogen peroxide. The remaining 5 groups were each treated with the wound dressings prepared in Examples 1-5 of this invention, with an application amount sufficient to cover the wound, applied once daily for one day each time. The wound condition was observed after 3 days of application.

[0060] The efficacy evaluation criteria are as follows:

[0061] Highly effective: wound healing.

[0062] Effective: The wound shrinks and there is no discharge.

[0063] Basically effective: No change in wound area, but reduced secretions.

[0064] Ineffective: No change in wound area, no reduction in secretions.

[0065] The results are shown in Table 1.

[0066] Table 1

[0067]

[0068]

[0069] As can be seen from Table 1, the combination of aloe vera gel and white tea extract in Examples 1-3 significantly improved the wound healing speed and increased the overall effective rate of wound recovery compared to the use of a single aloe vera gel or a single white tea extract in Examples 4 and 5.

[0070] 2. Clinical trials:

[0071] (1) Fifty volunteer patients with clinically diagnosed skin damage were selected. Among the volunteer patients, there were 28 males and 22 females, with an average age of 33.5 years (range 21-56 years). Among them, 45 patients had small superficial wounds and 5 patients had postoperative skin inflammatory reactions. The average medical history was 2 months (range 1-5 months).

[0072] (2) The above 50 volunteer patients were divided into 5 groups (one patient with postoperative skin inflammation in each group), with 10 patients in each group. The wound dressings prepared in Examples 1-5 were applied to each group. Before applying the dressing, the wound was cleaned with hydrogen peroxide. Then the wound dressings prepared in Examples 1-5 were applied to the damaged wounds of the volunteer patients. The dressings were changed once a day. The wound recovery was observed after 3 days.

[0073] (3) The efficacy evaluation criteria are as follows:

[0074] Highly effective: wound healing.

[0075] Effective: Wound shrinks, no discharge.

[0076] Basically effective: No change in wound area, but reduced secretions.

[0077] Ineffective: No change in wound area, no reduction in secretions.

[0078] The results are shown in Table 2.

[0079] Table 2

[0080]

[0081] The efficacy of the treatment for patients with inflammatory skin lesions in the five groups is as follows: Example 1 was effective, Example 2 was effective, Example 3 was effective, Example 4 was ineffective, and Example 5 was basically effective.

[0082] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A wound repair patch containing aloe vera gel, characterized in that, The active ingredient is a wound dressing containing aloe vera gel; The wound dressing containing aloe vera gel, by weight, consists of the following ingredients: 20-25 parts aloe vera gel, 7-10 parts chitosan, 100 parts polyvinyl alcohol, and 8-12 parts white tea extract. The aloe vera gel has a purity of ≥99.5%; The extraction method of the white tea extract is as follows: White peony is pulverized and passed through an 80-mesh sieve to obtain tea powder; the tea powder and a 5% acetic acid aqueous solution are mixed at a solid-liquid ratio of 1:15, and then ultrasonically extracted. The resulting filtrate is concentrated under reduced pressure to 1 / 15 of the original volume to obtain the white tea extract. The method for preparing the wound dressing containing aloe vera gel includes the following steps: After the raw materials are mixed evenly according to the mass fraction, electrospinning is performed to obtain the wound dressing containing aloe vera gel; the electrospinning rate is 1 mL / h, the voltage is 4 kV, and the spacing is 15 cm. The wound repair patch containing aloe vera gel also includes a breathable film, hot-air nonwoven fabric, release paper, and adhesive.

2. The wound repair patch containing aloe vera gel according to claim 1, characterized in that, Chitosan has a molecular weight of 8-15 kDa.

3. The wound repair patch containing aloe vera gel according to claim 1, characterized in that, The ultrasonic extraction temperature is 50-60℃.

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