An irreversible electroporation pulse generation system

Abstract

The application discloses an irreversible electroporation pulse generation system, comprising a power supply selection module, a control module and a pulse generation module; wherein the power supply selection module is used for selecting an output voltage according to a control signal sent by the control module; wherein the output voltage at least comprises a first voltage and a second voltage, and the first voltage and the second voltage are different in size; the pulse generation module is used for generating a bipolar pulse signal according to a trigger signal sent by the control module and the output voltage of the power supply selection module. The irreversible electroporation pulse generation system of the embodiment of the application can generate high-voltage high-frequency bipolar pulses and low-voltage low-frequency bipolar pulses, wherein the high-voltage high-frequency bipolar pulses can generate an electroporation effect without muscle contraction, and the low-voltage low-frequency bipolar pulses can enhance the electroporation effect without muscle contraction, thereby enhancing the tissue ablation effect and making the ablation more thorough.

Description

TECHNICAL FIELD

[0001] The embodiment of the present application relates to the technical field of high-voltage pulse medical technology application, in particular to an irreversible electroporation pulse generation system. BACKGROUND

[0002] Irreversible electroporation technology of pulse electric field has been successfully used in tissue ablation, and when ablation of undesirable tissue (such as malignant tumor), can effectively preserve the functional integrity of the surrounding important tissue (such as large blood vessels, nerves, etc.).

[0003] In the prior art, the single polarity pulse is used to ablate undesirable tissue, and the ablation effect is better, but the surrounding muscle tissue is contracted, so that the electrode needle is displaced, and the treatment effect is affected. High-frequency irreversible electroporation technology can effectively reduce the side effects caused by muscle contraction while ablation of undesirable tissue.

[0004] However, the pulse width of high-frequency irreversible electroporation technology is narrow, and the equivalent frequency is high, so the ablation effect is significantly low, that is, in the process of removing tumor tissue, tumor cell residues and incomplete tissue ablation may be caused. SUMMARY

[0005] The present application provides an irreversible electroporation pulse generation system, which can generate high-voltage high-frequency bipolar pulse and low-voltage low-frequency bipolar pulse, can reduce muscle contraction while enhancing tissue ablation effect.

[0006] The embodiment of the present application provides an irreversible electroporation pulse generation system, which comprises a power supply selection module, a control module and a pulse generation module; wherein the power supply selection module is electrically connected with the control module, and is used for selecting output voltage according to the control signal sent by the control module; wherein the output voltage at least includes first voltage and second voltage, and the first voltage and the second voltage are different in size; the pulse generation module is electrically connected with the power supply selection module and the control module respectively, and is used for generating bipolar pulse signal according to the trigger signal sent by the control module and the output voltage of the power supply selection module.

[0007] Optionally, the power supply selection module comprises: a first power supply, a second power supply and a first switch unit, the first power supply is configured to output a first voltage, the second power supply is configured to output a second voltage; the first switch unit is connected between the positive poles of the first power supply and the second power supply, the negative pole of the first power supply and the negative pole of the second power supply are electrically connected; the control end of the first switch unit is electrically connected with the control module; the positive pole and the negative pole of the second power supply are connected with the pulse generation module; the pulse generation module is configured to generate a first pulse waveform according to a first trigger signal output by the control module when the control module controls the first switch unit to be turned on, and generate a second pulse waveform according to a second trigger signal output by the control module when the control module controls the first switch unit to be turned off; wherein the voltage range of the first pulse waveform is greater than the voltage range of the second pulse waveform, and the pulse equivalent frequency of the first pulse waveform is higher than the pulse equivalent frequency of the second pulse waveform.

[0008] Optionally, the control end of the first switch unit is electrically connected with the control module through a first trigger unit, and the control module is configured to control the on-off state of the first switch unit by outputting a control signal to the first trigger unit.

[0009] Optionally, the voltage range of the first pulse waveform is greater than or equal to -6 kV and less than or equal to 6 kV, the pulse equivalent frequency range of the first pulse waveform is greater than or equal to 10 kHz and less than or equal to 2 MHz, and the pulse width range of the first pulse waveform is greater than or equal to 200 ns and less than or equal to 2 μs.

[0010] Optionally, the control module is configured to control the duration of each on time of the first switch unit to be greater than or equal to 20 μs and less than or equal to 10 ms, so that the pulse output time range of the first pulse waveform is greater than or equal to 20 μs and less than or equal to 10 ms.

[0011] Optionally, the voltage range of the second pulse waveform is greater than or equal to -0.6 kV and less than or equal to 0.6 kV, the pulse equivalent frequency range of the second pulse waveform is greater than or equal to 1 Hz and less than or equal to 500 Hz, the pulse width range of the second pulse waveform is greater than or equal to 1 ms and less than or equal to 500 ms, and the pulse output time range of the second pulse waveform is greater than or equal to 40 ms and less than or equal to 1 s.

[0012] Optionally, the control module is further configured to output a time interval of the off control signal and the on control signal to the first switch unit to be greater than or equal to 1 ms and less than or equal to 10 s, and output a time interval of the second trigger signal and the first trigger signal to the pulse generation module to be greater than or equal to 1 ms and less than or equal to 10 s, so that the interval time between the second pulse waveform and the first pulse waveform output by the pulse generation module is greater than or equal to 1 ms and less than or equal to 10 s.

[0013] Optionally, the power supply selection module further comprises an anti-reverse diode, a positive electrode of the anti-reverse diode is electrically connected with the positive electrode of the second power supply, and a negative electrode of the anti-reverse diode is electrically connected with the first switch unit and the common terminal of the pulse generation module.

[0014] Optionally, the pulse generation module comprises a trigger circuit and an H-bridge pulse generation circuit composed of the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit, the trigger circuit is electrically connected with the control module, the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit respectively, and the trigger circuit is used for controlling the conduction timing of the second switch unit, the third switch unit, the fourth switch unit and the fifth switch unit according to the trigger signal issued by the control module.

[0015] Optionally, the trigger circuit comprises a second trigger unit corresponding to the second switch unit, a third trigger unit corresponding to the third switch unit, a fourth trigger unit corresponding to the fourth switch unit and a fifth trigger unit corresponding to the fifth switch unit; the control module comprises an upper computer, a Field-Programmable Gate Array (FPGA) unit, a signal level enhancement unit and an electro-optical-electric conversion unit, the upper computer is used for sending an initial control signal and an initial trigger signal to the FPGA unit, the FPGA unit is used for enhancing the initial control signal to obtain a control signal and enhancing the initial trigger signal to obtain a trigger signal through the signal level enhancement unit, the signal level enhancement unit is used for transmitting the control signal to the power supply selection module and transmitting the trigger signal to the second trigger unit, the third trigger unit, the fourth trigger unit and the fifth trigger unit through the electro-optical-electric conversion unit.

[0016] The technical scheme of the embodiment of the application, by the power supply selection module selecting an output voltage according to the control signal issued by the control module, wherein the output voltage at least comprises a first voltage and a second voltage of different sizes; the pulse generation module generates an adjustable high-voltage high-frequency bipolar pulse or a low-voltage low-frequency bipolar pulse according to the trigger signal issued by the control module and the output voltage of the power supply selection module, wherein the high-voltage high-frequency bipolar pulse can produce an electroporation effect without muscle contraction, and the low-voltage low-frequency bipolar pulse can enhance the electroporation effect without muscle contraction, so as to reduce muscle contraction while enhancing tissue ablation effect, so that tissue ablation is more thorough. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 is a structure schematic diagram of an irreversible electroporation pulse generation system provided by the embodiment of the application;

[0018] Figure 2is a structural schematic diagram of another irreversible electroporation pulse generation system provided by an embodiment of the present application;

[0019] Figure 3 is a structural schematic diagram of another irreversible electroporation pulse generation system provided by an embodiment of the present application;

[0020] Figure 4 is a schematic diagram of a high-voltage high-frequency bipolar pulse output waveform provided by an embodiment of the present application;

[0021] Figure 5 is a schematic diagram of a low-voltage low-frequency bipolar pulse output waveform provided by an embodiment of the present application. DETAILED DESCRIPTION

[0022] The present application will be further described below in conjunction with the accompanying drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the present application, but not to limit the present application. In addition, it should be noted that, for the convenience of description, only the parts related to the present application are shown in the drawings, but not all the structures.

[0023] Figure 1 is a structural schematic diagram of an irreversible electroporation pulse generation system provided by an embodiment of the present application. The present embodiment can be applicable to the case of generating high-voltage high-frequency bipolar pulses and low-voltage low-frequency bipolar pulses to ablate tissues.

[0024] As shown in Figure 1 , the irreversible electroporation pulse generation system comprises a power supply selection module 10, a control module 20 and a pulse generation module 30; wherein the power supply selection module 10 is electrically connected with the control module 20, and is configured to select an output voltage according to a control signal sent by the control module 20; wherein the output voltage at least comprises a first voltage and a second voltage, and the first voltage and the second voltage are different in size; the pulse generation module 30 is electrically connected with the power supply selection module 10 and the control module 20 respectively, and is configured to generate a bipolar pulse signal according to a trigger signal sent by the control module 20 and the output voltage of the power supply selection module 10.

[0025] Specifically, the power supply selection module 10 can comprise a plurality of power supplies with different voltage sizes and a selection switch, and the output of different output voltages is realized by selecting the power supply through the selection switch. Optionally, the power supply selection module 10 selects the output voltage according to the control signal sent by the control module 20, wherein the output voltage at least comprises a first voltage and a second voltage, and the first voltage and the second voltage are different in size. Optionally, the value of the first voltage can be greater than the value of the second voltage, or the value of the first voltage can be less than the value of the second voltage.

[0026] The control module 20 can comprise a micro control unit. Alternatively, the control module 20 can comprise a single chip microcomputer, and can further comprise a digital signal processing (DSP) or an FPGA. The control module 20 is configured to control the power supply selection module 10 to select an output voltage. For example, when the control signal output by the control module 20 is at a high level, the power supply selection module 10 selects a first voltage as the output voltage; when the control signal output by the control module 20 is at a low level, the power supply selection module 10 selects a second voltage as the output voltage. The control module 20 is further configured to output a trigger signal to the pulse generation module 30 at the same time when the control signal is output to the power supply selection module 10, so as to realize the cooperation between the power supply selection module 10 and the pulse generation module 30, and further realize the time-sharing output of the high-voltage high-frequency bipolar pulse and the low-voltage low-frequency bipolar pulse. For example, when the control signal output by the control module 20 is at a high level, the power supply selection module 10 selects a first voltage as the output voltage, and the pulse generation module 30 generates a high-voltage high-frequency pulse waveform according to the trigger signal output by the control module 20. When the control signal output by the control module 20 is at a low level, the power supply selection module 10 selects a second voltage as the output voltage, and the pulse generation module 30 generates a low-voltage low-frequency pulse waveform according to the trigger signal output by the control module 20. The pulse generation module 30 can be an H-bridge pulse generation circuit, and the conduction timing of the switching unit in the H-bridge pulse generation circuit is controlled by the trigger signal output by the control module 20, so as to generate a pulse signal.

[0027] It should be noted that the pulse generation module 30 can also be realized by other circuits capable of generating pulse waveforms in the prior art, and the present embodiment is not limited in this regard.

[0028] The irreversible electroporation pulse generation system provided by the embodiment of the present application comprises a power supply selection module, a control module and a pulse generation module. The power supply selection module selects an output voltage according to a control signal output by the control module, wherein the output voltage comprises at least a first voltage and a second voltage with different sizes. The pulse generation module is configured to generate a high-voltage high-frequency bipolar pulse or a low-voltage low-frequency bipolar pulse with adjustable parameters according to a trigger signal output by the control module and the output voltage of the power supply selection module. The high-voltage high-frequency bipolar pulse can generate an electroporation effect without causing muscle contraction, and the low-voltage low-frequency bipolar pulse can enhance the electroporation effect without causing muscle contraction, so as to reduce muscle contraction and enhance tissue ablation effect, thereby achieving more thorough tissue ablation.

[0029] Figure 2 FIG. 4 is a structural schematic diagram of another irreversible electroporation pulse generation system provided by the embodiment of the present application. Referring to FIG. 4, the irreversible electroporation pulse generation system comprises a power supply selection module 10, a control module 20 and a pulse generation module 30. The power supply selection module 10 is configured to select an output voltage according to a control signal output by the control module 20. The pulse generation module 30 is configured to generate a high-voltage high-frequency bipolar pulse or a low-voltage low-frequency bipolar pulse with adjustable parameters according to a trigger signal output by the control module 20 and the output voltage of the power supply selection module 10. Figure 2Optionally, the power supply selection module 10 comprises: a first power supply V1, a second power supply V2 and a first switch unit S1, the first power supply V1 is configured to output a first voltage, the second power supply V2 is configured to output a second voltage; the first switch unit S1 is connected between the positive poles of the first power supply V1 and the second power supply V2, the negative pole of the first power supply V1 and the negative pole of the second power supply V2 are electrically connected; the control terminal of the first switch unit S1 is electrically connected with the control module 20; the positive pole and the negative pole of the second power supply V2 are connected with the pulse generation module 30; the pulse generation module 30 is configured to generate a first pulse waveform according to the first trigger signal output by the control module 20 when the control module 20 controls the first switch unit S1 to be turned on, and generate a second pulse waveform according to the second trigger signal output by the control module 20 when the control module 20 controls the first switch unit S1 to be turned off; wherein the voltage range of the first pulse waveform is greater than the voltage range of the second pulse waveform, and the pulse equivalent frequency of the first pulse waveform is higher than the pulse equivalent frequency of the second pulse waveform. In other words, the first pulse waveform is a high-voltage high-frequency pulse, and the second pulse waveform is a low-voltage low-frequency pulse. Optionally, the first power supply V1 is a high-voltage direct current power supply, the second power supply V2 is a low-voltage direct current power supply, and the first voltage output by the first power supply V1 is greater than the second voltage output by the second power supply V2.

[0030] When the first switch unit S1 is turned on, the first power supply V1 outputs the first voltage, and the pulse generation module 30 generates the first pulse waveform (high-voltage high-frequency pulse waveform) according to the first trigger signal output by the control module 20. When the first switch unit S1 is turned off, the second power supply V2 outputs the second voltage, and the pulse generation module 30 generates the second pulse waveform (low-voltage low-frequency pulse waveform) according to the second trigger signal output by the control module 20. The first pulse waveform and the second pulse waveform generated by the pulse generation module 30 act on the target cells. Optionally, the control terminal of the first switch unit S1 is electrically connected with the control module 20 through the first trigger unit 1, and the control module 20 is configured to control whether the first switch unit S1 is turned on by outputting a control signal to the first trigger unit 1.

[0031] Specifically, when the first switch unit S1 is turned on, the first power supply V1 outputs a first voltage, and the trigger signal sent by the control module 20 can control the opening and closing of the plurality of switches in the pulse generation module 30, so as to inversely convert the direct current (the first voltage) into a first pulse waveform. By changing the amplitude of the first voltage, the voltage range of the first pulse waveform can be changed, and by controlling the on and off time of the plurality of switches, the pulse equivalent frequency range, the pulse width range and the pulse output time range of the first pulse waveform can be controlled. Further, the voltage range of the first pulse waveform is greater than or equal to -6 kV and less than or equal to 6 kV, the pulse equivalent frequency range of the first pulse waveform is greater than or equal to 10 kHz and less than or equal to 2 MHz, and the pulse width range of the first pulse waveform is greater than or equal to 200 ns and less than or equal to 2 μs. The control module 20 is used to control the duration of each continuous conduction of the first switch unit S1 to be greater than or equal to 20 μs and less than or equal to 10 ms, so that the pulse output time range of the first pulse waveform is greater than or equal to 20 μs and less than or equal to 10 ms. That is, the irreversible electroporation pulse generation system of the present application can generate a high-voltage high-frequency pulse waveform with flexible adjustable parameter range. Similarly, when the first switch unit S1 is turned off, the second power supply V2 outputs a second voltage, and the trigger signal sent by the control module 20 can control the opening and closing of the plurality of switches in the pulse generation module 30, so as to inversely convert the second voltage into a second pulse waveform. By changing the amplitude of the second voltage, the voltage range of the second pulse waveform can be changed, and by controlling the on and off time of the plurality of switches, the pulse equivalent frequency range, the pulse width range and the pulse output time range of the second pulse waveform can be controlled. Further, the voltage range of the second pulse waveform is greater than or equal to -0.6 kV and less than or equal to 0.6 kV, the pulse equivalent frequency range of the second pulse waveform is greater than or equal to 1 Hz and less than or equal to 500 Hz, the pulse width range of the second pulse waveform is greater than or equal to 1 ms and less than or equal to 500 ms, and the pulse output time range of the second pulse waveform is greater than or equal to 40 ms and less than or equal to 1 s. For example, the voltage of the first pulse waveform can be 3 kV, the pulse width can be 1 μs, and the pulse equivalent frequency can be 100 kHz; the voltage of the second pulse waveform can be 50 V, the pulse width can be 50 ms, and the pulse equivalent frequency can be 8.33 Hz. The interval time between the first pulse waveform and the second pulse waveform can be 10 ms. The present application generates the first pulse waveform according to the first trigger signal sent by the control module 20, and generates the second pulse waveform according to the second trigger signal sent by the control module 20.In other words, the present application can generate high-voltage high-frequency pulse waveform with flexible adjustable parameter range and low-voltage low-frequency pulse waveform with flexible adjustable parameter range, wherein the high-voltage high-frequency pulse waveform is used to generate electroporation effect without muscle contraction, and the low-voltage low-frequency pulse waveform is used to enhance the electroporation effect, thereby enhancing the tissue ablation effect and making the tissue ablation more thorough. At the same time, since the waveform generated by the irreversible electroporation pulse generation system of the present application has a symmetric characteristic, it will not produce obvious electrolysis effect, thereby ensuring the safety of clinical application.

[0032] The power supply selection module 10 further comprises an anti-reverse diode D1, the positive electrode of the anti-reverse diode D1 is electrically connected with the positive electrode of the second power supply V2, and the negative electrode of the anti-reverse diode D1 is electrically connected with the common terminal of the first switch unit S1 and the pulse generation module 30. The anti-reverse diode D1 has the characteristics of forward conduction and reverse cut-off, and the unidirectional conduction of the anti-reverse diode D1 can prevent the irreversible electroporation pulse generation system from being damaged by the impact of the second power supply V2 when outputting the first pulse waveform (high-voltage high-frequency pulse). The power supply selection module 10 further comprises a first freewheeling diode D2, the positive electrode of the first freewheeling diode D2 is connected with the negative electrode of the anti-reverse diode D1, and the negative electrode of the first freewheeling diode D2 is electrically connected with the positive electrode of the first power supply V1. The first freewheeling diode D2 is used for freewheeling.

[0033] The irreversible electroporation pulse generation system further comprises a first capacitor C1 and a second capacitor C2, the first capacitor C1 is connected in parallel across the first power supply V1, and the second capacitor C2 is connected in parallel across the second power supply V2. The first capacitor C1 and the second capacitor C2 are voltage stabilizing capacitors. The charged energy of the first power supply V1 is stored in the first capacitor C1, and the charged energy of the second power supply V2 is stored in the second capacitor C2.

[0034] The pulse generation module 30 comprises a trigger circuit and an H-bridge pulse generation circuit composed of the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5, and the trigger circuit is electrically connected with the control module 20, the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5, respectively. The trigger circuit is used to control the conduction timing of the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5 according to the trigger signal issued by the control module 20.

[0035] Optionally, the trigger circuit comprises a second trigger unit 2 corresponding to the second switch unit S2, a third trigger unit 3 corresponding to the third switch unit S3, a fourth trigger unit 4 corresponding to the fourth switch unit S4, and a fifth trigger unit 5 corresponding to the fifth switch unit S5.

[0036] Specifically, the second switch unit S2 is connected with the second trigger unit 2, the third switch unit S3 is connected with the third trigger unit 3, the fourth switch unit S4 is connected with the fourth trigger unit 4, and the fifth switch unit S5 is connected with the fifth trigger unit 5. The first trigger signal sent by the control module 20 is a group of trigger signals, and the second trigger signal is also a group of trigger signals. One group of trigger signals can include four-way trigger signals for the second trigger unit 2, the third trigger unit 3, the fourth trigger unit 4 and the fifth trigger unit 5. In an optional embodiment of the present application, the control signal and the first trigger signal sent by the control module 20 to the power selection module 10 can be used as a group of control signals, and the control signal and the second trigger signal sent by the control module 20 to the power selection module 10 can also be used as a group of control signals.

[0037] Optionally, the first switch unit S1, the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5 can be bipolar power triodes, and can also be field effect transistors. The four diodes (the first diode D3, the second diode D4, the third diode D5 and the fourth diode D6) connected in parallel with the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5 can be Schottky diodes.

[0038] When the control signal output by the control module 20 is high, the first switch unit S1 is turned on, the first power supply V1 outputs a first voltage after being stabilized by the first capacitor C1, and the pulse generation module 30 generates a first pulse waveform (high-voltage high-frequency pulse waveform) according to the first trigger signal sent by the control module 20. When the control signal output by the control module 20 is low, the first switch unit S1 is turned off, the second power supply V2 outputs a second voltage after being stabilized by the second capacitor C2, and the pulse generation module 30 generates a second pulse waveform (low-voltage low-frequency pulse waveform) according to the second trigger signal sent by the control module 20.

[0039] The working principle of the H-bridge pulse generation circuit is as follows:

[0040] The second switch unit S2 and the fifth switch unit S5 are turned on and the third switch unit S3 and the fourth switch unit S4 are turned off by the trigger signal sent by the control module 20, so that the upper half-axis part of the pulse waveform is generated. The second switch unit S2 and the fifth switch unit S5 are turned on and the third switch unit S3 and the fourth switch unit S4 are turned off by the trigger signal sent by the control module 20, so that the lower half-axis part of the pulse waveform is generated.

[0041] Figure 3 is another structure diagram of an irreversible electroporation pulse generation system provided by the embodiment of the present application.

[0042] Reference Figure 3Optionally, the control module 20 comprises a host computer 201, an FPGA unit 202, a signal level enhancement unit 203 and an electro-optical-electro conversion unit 204, the host computer 201 is configured to send an initial control signal and an initial trigger signal to the FPGA unit 202, the FPGA unit 202 is configured to enhance the initial control signal to obtain a control signal and enhance the initial trigger signal to obtain a trigger signal through the signal level enhancement unit 203, the signal level enhancement unit 203 is configured to transmit the control signal to the power supply selection module 10 through the electro-optical-electro conversion unit 204, and transmit the trigger signal to the second trigger unit 2, the third trigger unit 3, the fourth trigger unit 4 and the fifth trigger unit 5 through the electro-optical-electro conversion unit 204, so as to prevent the output pulse from interfering with the trigger signal during treatment.

[0043] The host computer 201 sends a communication instruction to the FPGA unit 202 through a human-computer interaction interface, and the FPGA unit 202 enhances the control signal and the trigger signal through the signal level enhancement unit 203 to prevent the output pulse from interfering with the control signal during treatment. For example, the trigger signal sent by the FPGA unit 202 is a 3.3 V level signal, which is easily interfered by a high-voltage high-frequency pulse signal, so the level needs to be raised (such as 5 V). The raised trigger signal is transmitted to the trigger units in the trigger circuit through the electro-optical-electro conversion unit 204. As described above, the trigger signal includes four-way trigger signals for the second trigger unit 2, the third trigger unit 3, the fourth trigger unit 4 and the fifth trigger unit 5. According to different required pulse waveforms, the trigger signals for different trigger units can be the same or different. After receiving the trigger signal sent by the control module 20, the second trigger unit 2 controls whether the second switch unit S2 is turned on according to the received trigger signal; after receiving the trigger signal sent by the control module 20, the third trigger unit 3 controls whether the third switch unit S3 is turned on according to the received trigger signal; after receiving the trigger signal sent by the control module 20, the fourth trigger unit 4 controls whether the fourth switch unit S4 is turned on according to the received trigger signal; after receiving the trigger signal sent by the control module 20, the fifth trigger unit 5 controls whether the fifth switch unit S5 is turned on according to the received trigger signal, so as to make the second switch unit S2, the third switch unit S3, the fourth switch unit S4 and the fifth switch unit S5 be turned on according to the specific trigger signal respectively, thereby sending a pulse waveform to the targeted tissue.

[0044] Optionally, the irreversible electroporation pulse generation system further comprises a power supply module 40, the power supply module 40 comprises a mains power supply 401 and an AC / DC conversion unit 402; the mains power supply 401 is electrically connected with the AC / DC conversion unit 402, the AC / DC conversion unit 402 is electrically connected with the power supply selection module 10 to provide voltage for the power supply selection module 10; the power supply module 40 is further electrically connected with the control module 20 to supply power for the control module 20.

[0045] The AC / DC conversion unit 402 converts the AC power into DC power, and the DC power is divided into two parts, one part is used to supply power for the FPGA unit 202; the other part is used to supply power for the first power supply and the second power supply in the power supply selection module 10. The mains power supply 401 is connected with the upper computer 201 to supply power for the upper computer 201.

[0046] Figure 4 is a schematic diagram of a high-voltage high-frequency bipolar pulse output waveform provided by an embodiment of the present application.

[0047] Reference is made to Figure 4 , in the high-voltage high-frequency pulse waveform, the voltage range is greater than or equal to -3 kV and less than or equal to 3 kV, the pulse width is 1 μs, and the pulse equivalent frequency is 100 kHz.

[0048] Figure 5 is a schematic diagram of a low-voltage low-frequency bipolar pulse output waveform provided by an embodiment of the present application. Reference is made to Figure 5 , in the low-voltage low-frequency pulse waveform, the voltage range is greater than or equal to -0.1 kV and less than or equal to 0.1 kV.

[0049] Note that the above are only preferred embodiments of the present application and the technical principles applied. Those skilled in the art will understand that the present application is not limited to the specific embodiments described herein, and those skilled in the art can make various obvious changes, re-adjustments and substitutions without departing from the scope of the present application. Therefore, although the present application has been described in more detail through the above embodiments, the present application is not limited to the above embodiments, and can include more other equivalent embodiments without departing from the concept of the present application, and the scope of the present application is determined by the scope of the appended claims.

Claims

1. An irreversible electroporation pulse generation system, characterized in that, include: Power selection module, control module, and pulse generation module; The power selection module is electrically connected to the control module and is used to select the output voltage according to the control signal issued by the control module; wherein the output voltage includes at least a first voltage and a second voltage, and the first voltage and the second voltage are of different magnitudes; The pulse generation module is electrically connected to the power selection module and the control module respectively, and is used to generate a bipolar pulse signal according to the trigger signal issued by the control module and the output voltage of the power selection module. The power selection module includes: The system comprises a first power supply, a second power supply, and a first switching unit. The first power supply is used to output the first voltage, and the second power supply is used to output the second voltage. The first switching unit is connected between the positive terminals of the first power supply and the second power supply, and the negative terminals of the first power supply and the second power supply are electrically connected. The control terminal of the first switching unit is electrically connected to the control module. The pulse generating module is connected between the positive and negative terminals of the second power supply; The pulse generation module is used to generate a first pulse waveform according to a first trigger signal issued by the control module when the control module controls the first switch unit to be turned on; and is used to generate a second pulse waveform according to a second trigger signal issued by the control module when the control module controls the first switch unit to be turned off. The control terminal of the first switching unit is electrically connected to the control module through the first triggering unit. The control module is used to control whether the first switching unit is turned on by outputting the control signal to the first triggering unit. Wherein, the voltage range of the first pulse waveform is greater than the voltage range of the second pulse waveform, and the pulse equivalent frequency of the first pulse waveform is higher than the pulse equivalent frequency of the second pulse waveform. The control module is used to control the continuous conduction time of the first switching unit to be greater than or equal to 20 μs and less than or equal to 10 ms, so that the pulse output time range of the first pulse waveform is greater than or equal to 20 μs and less than or equal to 10 ms.

2. The irreversible electroporation pulse generation system according to claim 1, characterized in that, The voltage range of the first pulse waveform is greater than or equal to -6 kV and less than or equal to 6 kV, the pulse equivalent frequency range of the first pulse waveform is greater than or equal to 10 kHz and less than or equal to 2 MHz, and the pulse width range of the first pulse waveform is greater than or equal to 200 ns and less than or equal to 2 μs.

3. The irreversible electroporation pulse generation system according to claim 1, characterized in that, The voltage range of the second pulse waveform is greater than or equal to -0.6 kV and less than or equal to 0.6 kV, the pulse equivalent frequency range of the second pulse waveform is greater than or equal to 1 Hz and less than or equal to 500 Hz, the pulse width range of the second pulse waveform is greater than or equal to 1 ms and less than or equal to 500 ms, and the pulse output time range of the second pulse waveform is greater than or equal to 40 ms and less than or equal to 1 s.

4. The irreversible electroporation pulse generation system according to claim 1, characterized in that, The control module is further configured to output a turn-off control signal and a turn-on control signal to the first switching unit at a time interval greater than or equal to 1 ms and less than or equal to 10 s, and to output a second trigger signal and a first trigger signal to the pulse generation module at a time interval greater than or equal to 1 ms and less than or equal to 10 s, so that the interval between the second pulse waveform and the first pulse waveform output by the pulse generation module is greater than or equal to 1 ms and less than or equal to 10 s.

5. The irreversible electroporation pulse generation system according to claim 1, characterized in that, The power selection module further includes a reverse protection diode, the positive terminal of which is electrically connected to the positive terminal of the second power supply, and the negative terminal of which is electrically connected to the common terminal of the first switching unit and the pulse generation module.

6. The irreversible electroporation pulse generation system according to any one of claims 1-5, characterized in that, The pulse generation module includes an H-bridge pulse generation circuit composed of a trigger circuit, a second switch unit, a third switch unit, a fourth switch unit, and a fifth switch unit. The trigger circuit is electrically connected to the control module, the second switch unit, the third switch unit, the fourth switch unit, and the fifth switch unit, respectively. The trigger circuit is used to control the conduction timing of the second switch unit, the third switch unit, the fourth switch unit, and the fifth switch unit according to the trigger signal issued by the control module.

7. The irreversible electroporation pulse generation system according to claim 6, characterized in that, The trigger circuit includes a second trigger unit connected to the second switch unit, a third trigger unit connected to the third switch unit, a fourth trigger unit connected to the fourth switch unit, and a fifth trigger unit connected to the fifth switch unit. The control module includes a host computer, an FPGA unit, a signal level enhancement unit, and an electro-optical-electrical conversion unit. The host computer sends an initial control signal and an initial trigger signal to the FPGA unit. The FPGA unit enhances the initial control signal to obtain the control signal and enhances the initial trigger signal to obtain the trigger signal through the signal level enhancement unit. The signal level enhancement unit transmits the control signal to the power selection module through the electro-optical-electrical conversion unit and transmits the trigger signal to the second trigger unit, the third trigger unit, the fourth trigger unit, and the fifth trigger unit through the electro-optical-electrical conversion unit.

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