Flexible self-powered band-aid

Abstract

The present invention discloses a flexible self-powered band-aid, which is composed of a protective layer, a dressing layer, a base layer, and a nanogenerator layer connected in sequence from bottom to top. The protective layer is release paper; the dressing layer is a PVA / MXene hydrogel; the base layer is medical adhesive tape; the nanogenerator layer, as a functional layer, is made of an Ecoflex silicone rubber composite polyvinyl alcohol (PVA), boric acid, MXene, and glycerol system hydrogel. This self-powered flexible band-aid can generate charge transfer through the bending deformation generated by normal human movement, friction with clothing, etc. without the need for an additional power supply, and then generate current for real-time electrical stimulation; the shape and size of this self-generating band-aid can be adjusted, it has stronger flexibility, a larger deformation rate, and can closely fit the skin; the preparation process is simple and only requires simple heating equipment to complete the production.

Description

Technical Field

[0001] The present invention relates to the field of biomedical materials, and particularly to a flexible self-powered band-aid. Background Art

[0002] Diabetes is a major health problem affecting millions of people globally, and its prevalence is increasing rapidly year by year. The World Health Organization (WHO) estimates that by 2030, diabetes will become the seventh leading cause of death after ischemic heart disease, stroke, chronic obstructive pulmonary disease, lower respiratory tract infections, Alzheimer's disease, tracheal cancer, bronchial cancer, and lung cancer. Diabetic patients have a decreased ability to metabolize glucose, leading to hyperglycemia, which can damage and hinder the wound healing process. Especially when diabetic patients are accompanied by poor lower limb circulation problems, it will lead to frequent and chronic leg or foot ulcers. Diabetic ulcers can cause serious consequences, including deterioration of the patient's health, increased risk of amputation, and death. Studies on fibroblasts extracted from non-diabetic donors have shown that electrostimulation (ES) based on conductive polymers can not only promote the proliferation of fibroblasts but also increase the ability of these cells to produce extracellular matrix (ECM). In addition, compared with cells without ES, fibroblasts treated with ES can secrete higher levels of cytokines and growth factors. At the same time, ES can also increase the blood flow and oxygen content of the injured tissue, promote angiogenesis, stimulate the synthesis of collagen, activate re-epithelialization through the directional migration of keratinocytes, and reduce edema and pain. A large amount of clinical data has confirmed the role of ES in shortening wound healing and reducing pain, especially in difficult-to-heal chronic wounds. However, traditional electrostimulation devices are bulky and expensive, and require professional equipment and personnel for treatment operations, resulting in the inability to perform treatment in real time, making this effective treatment method not widely promoted and used.

[0003] Most current electrostimulation devices are relatively bulky professional electrostimulation devices that require a wired power supply to provide electrical energy. Even some current miniaturized electrostimulation devices are not only expensive but also require trained personnel to operate, so they cannot perform real-time electrostimulation treatment on wounds. Summary of the Invention

[0004] Aiming at the problems of high cost and inconvenient use of electrostimulation devices, the present invention provides a method for preparing and using a flexible self-powered band-aid. This self-powered band-aid can maintain a high power generation efficiency for a long time, and the nanogenerator will not become brittle due to water loss of the functional layer hydrogel.

[0005] To achieve the above object, the present invention provides a flexible self-powered band-aid, which is characterized in that it is composed of a protective layer, a dressing layer, a base layer, and a nanogenerator layer connected in sequence from bottom to top; the components of the nanogenerator layer and the dressing layer include PVA-1788, PVA-1799, MXene, Ecoflex, borate, glycerol, and water.

[0006] As a preferred solution, the protective layer is release paper; the dressing layer is a PVA / MXene hydrogel; the base layer is medical adhesive tape; the nanogenerator layer, as a functional layer, is made of an Ecoflex silicone rubber composite polyvinyl alcohol (PVA), boric acid, MXene, glycerol system hydrogel.

[0007] As a preferred solution, the dressing layer is prepared by mixing PVA-1799 and MXene in a volume ratio of 1:2 - 1:4, heating, and then subjecting to repeated freezing-thawing; the base layer is medical adhesive tape; the nanogenerator layer is composed of PVA-1788, borate heated and mixed in a mass ratio of 3:1 - 8:1, and Ecoflex.

[0008] Furthermore, the borate includes metaborate, orthoborate, and polyborate.

[0009] Furthermore, in terms of mass / volume ratio, that is, the ratio of solute mass to total volume, the concentration of the prepared PVA-1788 solution is 0.5 - 25%, the concentration of MXene is 0.1 - 10%, the concentration of borate is 0.1 - 20%, and the concentration of glycerol is 0.1 - 100%; the concentration of PVA-1799 is 1 - 30%, and the concentration of MXene is 3 - 15%.

[0010] Furthermore, the heating temperature of PVA-1799 is 90 - 110°C, the freezing temperature is -20°C, the freezing time is 1 - 10 h / time, and the thawing time is 0.5 - 3 h / time.

[0011] The method for preparing the flexible self-powered band-aid as described above includes the following steps:

[0012] S1: Prepare the dressing layer, and the specific steps are:

[0013] S1.1) Prepare aqueous solutions of PVA 1799 and MXene respectively;

[0014] S1.2) Mix the aqueous solutions of PVA 1799 and MXene evenly, and use an ultrasonic machine to remove air bubbles;

[0015] S1.3) Coat the solution described in step S1.2 on one side of the medical adhesive tape;

[0016] S1.4) Freeze the medical adhesive tape in step S1.3 in a refrigerator, and then take it out to thaw at room temperature;

[0017] S1.5) Repeat step S1.4;

[0018] The dressing layer simultaneously serves as a conductive electrode layer and makes direct contact with the wound;

[0019] S2: Ecoflex silicone rubber, PVA 1788, glycerol, MXene and borate are cross-linked and then naturally dehydrated to obtain a flexible self-powered band-aid. The specific steps are as follows:

[0020] S2.1) Dig a small hole in the center of the medical adhesive tape, fully mix the PVA 1788 solution and borate glycerol, cover the small hole after removing the bubbles by ultrasonic treatment, and dry it at room temperature;

[0021] S2.2) Mix Ecoflex A and B in a ratio of 1:1, remove the bubbles, and then coat the hydrogel in step S2.1 until it solidifies, and then a flexible nanogenerator can be prepared.

[0022] The advantages and beneficial effects of the present invention are as follows:

[0023] The self-powered band-aid of the present invention can maintain a high power generation efficiency for a long time, and the nanogenerator will not become brittle due to water loss of the functional layer hydrogel.

[0024] 1. Under the condition of no additional power supply, charge transfer can be generated through the bending deformation generated by normal human actions, friction with clothing, etc., and then current can be generated for real-time electrical stimulation;

[0025] 2. No special personnel operation is required, it is simple to use, and the usage method is exactly the same as that of ordinary band-aids;

[0026] 3. The shape and size of the self-powered band-aid can be adjusted, it has stronger flexibility, a larger deformation rate, and can be closely attached to the skin;

[0027] 4. The preparation process is simple, and only a simple heating device is required to complete the production. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of the overall structure of the flexible self-powered band-aid of the present invention;

[0029] Figure 2 It is a power generation effect diagram of the flexible band-aid of the present invention when the finger is bent;

[0030] Figure 3 It is a power generation effect diagram of the flexible band-aid of the present invention when the arm is bent;

[0031] Figure 4Schematic diagram of the mechanism of the generator of the present invention;

[0032] In the figure: 1. Nanogenerator layer; 2. Substrate layer; 3. Dressing layer; 4. Protective layer. Specific implementation mode

[0033] The technical solution of the present invention will be further elaborated in detail below in conjunction with the accompanying drawings and embodiments.

[0034] Embodiment 1

[0035] First, 20 g of PVA-1799 and 5 g of MXene are heated and stirred at 95 °C and dissolved in 100 mL of water. After stirring evenly, it is coated on one side of a medical adhesive tape with a small hole in the middle, and then placed in a refrigerator at -20 °C for two hours; then it is thawed at room temperature for half an hour, and this step is repeated 3 times to obtain the hydrogel of the dressing layer 3;

[0036] Secondly, 5 g of PVA-1788 and 5 g of MXene are added to 100 mL of water, and heated and stirred at 60 °C for 4 h to completely dissolve. Separately, 5 g of Na2B4O7·10H2O is heated and dissolved in 100 mL of a glycerol / water (1:9) mixture. Then the PVA-1788 aqueous solution and the Na2B4O7·10H2O solution are mixed and stirred in a ratio of 7:1. After stirring evenly, it is coated on the other side of the medical adhesive tape to completely cover the small hole in the middle, and dried at room temperature for 6 h to obtain the hydrogel of the nanogenerator layer 1; then Ecoflex A and B are mixed evenly in a ratio of 1:1 and coated on the hydrogel of the nanogenerator layer 1 and cured for 4 hours; finally, the adhesive layer of the medical adhesive tape is encapsulated with release paper.

[0037] Finally, the assembled self-powered flexible band-aid is applied to the finger, and the power generation performance is tested by the natural bending of the finger, as Figure 2 shown.

[0038] Embodiment 2

[0039] First, 15 g of PVA-1799 and 5 g of MXene are heated and stirred at 95 °C and dissolved in 100 mL of water. After stirring evenly, it is coated on one side of a medical adhesive tape with a small hole in the middle, and then placed in a refrigerator at -20 °C for two hours; then it is thawed at room temperature for 1 hour, and this step is repeated 5 times to obtain the hydrogel of the dressing layer 3;

[0040] Secondly, 5 g of PVA-1788 and 5 g of MXene were added to 100 mL of water, and the mixture was heated and stirred at 60 °C for 4 h until completely dissolved. Separately, 5 g of Na2B4O7·10H2O was heated and dissolved in 100 mL of a glycerol / water (1:9) mixture. Then, the PVA-1788 aqueous solution and the Na2B4O7·10H2O solution were mixed and stirred in a ratio of 7:1. After stirring evenly, the mixture was coated on the other side of the medical adhesive tape to completely cover the middle small hole, and dried at room temperature for 6 h to obtain the hydrogel of nanogenerator layer 1; then, Ecoflex A and B were mixed evenly in a ratio of 1:1 and coated on the hydrogel of nanogenerator layer 1 and cured for 4 h; finally, the adhesive layer of the medical adhesive tape was encapsulated with release paper.

[0041] Finally, the assembled self-powered flexible band-aid was attached to the arm, and the power generation performance was tested by the natural bending of the arm. The power generation performance is as Figure 3 shown.

[0042] Example 3

[0043] First, 15 g of PVA-1799 and 5 g of MXene were heated and stirred at 95 °C and dissolved in 100 mL of water. After stirring evenly, the mixture was coated on one side of the medical adhesive tape with a small hole in the middle, and the tape was placed in a -20 °C refrigerator and frozen for two hours; then, it was thawed at room temperature for 1 h, and this step was repeated 5 times to obtain the hydrogel of dressing layer 3;

[0044] Secondly, 5 g of PVA-1788 and 5 g of MXene were added to 100 mL of water, and the mixture was heated and stirred at 60 °C for 4 h until completely dissolved. Separately, 2.5 g of Na2B4O7·10H2O was heated and dissolved in 50 mL of glycerol. Then, the PVA-1788 aqueous solution and the Na2B4O7·10H2O solution were mixed and stirred in a ratio of 7:1. After stirring evenly, the mixture was coated on the other side of the medical adhesive tape to completely cover the middle small hole, and dried at room temperature for 6 h to obtain the hydrogel of nanogenerator layer 1; then, Ecoflex A and B were mixed evenly in a ratio of 1:1 and coated on the hydrogel of nanogenerator layer 1 and cured for 4 h; finally, the adhesive layer of the medical adhesive tape was encapsulated with release paper.

[0045] The assembled self-powered flexible band-aid was attached to body affected parts such as fingers and arms, and the fitting performance and power generation performance of the self-powered flexible band-aid were tested by the natural bending of the limbs. The power generation mechanism is as Figure 4 shown.

[0046] Example 4

[0047] First, 15 g of PVA-1799 and 2.5 g of MXene are heated and stirred at 95 °C and dissolved in 100 mL of water. After stirring evenly, it is coated on one side of a medical adhesive tape with a small hole in the middle, and then placed in a refrigerator at -20 °C for two hours. Then it is thawed at room temperature for 1 hour, and this step is repeated 5 times to obtain the hydrogel of the dressing layer 3.

[0048] Secondly, 5 g of PVA-1788 and 5 g of MXene are added to 100 mL of water, and heated and stirred at 60 °C for 4 h to completely dissolve. Separately, 5 g of Na2B4O7·10H2O is heated and dissolved in 100 mL of a glycerol / water (1:9) mixture. Then the PVA-1788 aqueous solution and the Na2B4O7·10H2O solution are mixed and stirred in a ratio of 5:1. After stirring evenly, it is coated on the other side of the medical adhesive tape to completely cover the small hole in the middle, and dried at room temperature for 6 h to obtain the hydrogel of the nanogenerator layer 1. Then, Ecoflex A and B are mixed evenly in a ratio of 1:1 and coated on the hydrogel of the nanogenerator layer 1 and cured for 4 hours. Finally, the adhesive layer of the medical adhesive tape is encapsulated with release paper.

[0049] Finally, the assembled self-powered flexible band-aid is attached to the affected areas of the body such as fingers and arms, and the power generation performance is tested by the natural bending of the fingers and arms.

[0050] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the inventive concept of the present invention, several improvements and transformations are made, and these all belong to the protection scope of the present invention.

Claims

1. A flexible self-powered band-aid, characterized in that: It is composed of a protective layer, a dressing layer, a base layer, and a nanogenerator layer that are connected in sequence from bottom to top; The protective layer is release paper; The base layer is medical adhesive tape; The dressing layer is prepared by mixing PVA-1799 and MXene in a volume ratio of 1:2 - 1:4, heating, and then subjecting to repeated freezing-thawing to obtain PVA / MXene hydrogel; The nanogenerator layer, as a functional layer, is made of Ecoflex silicone rubber and a hydrogel system of PVA-1788, borate, MXene, and glycerol.

2. The flexible self-powered band-aid according to claim 1, characterized in that: The borate includes metaborate, orthoborate, and polyborate.

3. The flexible self-powered band-aid according to claim 2, wherein: The heating temperature of the PVA-1799 is 90 - 110 °C, the freezing temperature is -20 °C, the freezing time is 1 - 10 h / time, and the thawing time is 0.5 - 3 h / time.

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