Composition with skin barrier repair function and its application

Abstract

This application relates to the field of cosmetics, and specifically discloses a composition with a skin barrier repair function and its applications. The composition with a skin barrier repair function comprises the following components in parts by weight: 20-40 parts of functional microcapsules; 10-15 parts of Isatis indigotica extract; 3-5 parts of hydrolyzed Abelmoschus esculentus extract; the core material of the functional microcapsules comprises ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:(1.5-3):(0.8-1.5). The composition of the present application can be used to prepare cosmetics, and has the advantages of better soothing and repairing the skin.

Description

Technical Field

[0001] The present application relates to the field of cosmetics, and more specifically, it relates to a composition with a skin barrier repair function and its application. Background Art

[0002] The skin is the largest organ of the human body, covering the body surface and directly contacting the external environment, playing roles such as protection, excretion, body temperature regulation, and perception of external stimuli. The skin plays a very important barrier role for the human body. Having a healthy skin barrier is equivalent to having beautiful and natural skin. However, due to reasons such as environmental pollution, improper diet, irregular living schedules, and improper use of cosmetics, the skin is extremely prone to being sensitive and damaged, thus affecting the barrier and protection functions of the skin. Seriously, it will make the skin in a highly intolerant state, and this state of the skin is called sensitive skin. People with sensitive skin are prone to being stimulated by various factors and generating symptoms such as stinging, burning, tightness, and itching.

[0003] With the improvement of living standards, people pay more and more attention to health. The frequent occurrence of the above-mentioned skin symptoms brings great troubles to people's lives. Therefore, people pay more and more attention to and favor cosmetics with soothing and repairing effects. At present, the following methods are often used to endow cosmetic compositions with soothing or repairing effects: (1) adding humectants, such as hyaluronic acid, small molecule polyols, polysaccharides and other substances, to achieve the effect of soothing and repairing the skin by increasing the moisture in the skin; (2) adding ceramide to supplement the skin ceramide so as to achieve the effect of repairing the skin barrier.

[0004] Although the above existing methods have a certain soothing and repairing effect on the skin, humectants often can only supplement water in a short term, and the skin repair effect is very limited. Although ceramide can repair the skin barrier, it cannot effectively soothe the allergic reaction of the skin in a timely manner. Therefore, it is of great significance to develop a composition with a better soothing and repairing effect on the skin. Summary of the Invention

[0005] In order to improve the soothing and repairing effect on the skin, the present application provides a composition with a skin barrier repair function and its application.

[0006] In the first aspect, the present application provides a composition with a skin barrier repair function, adopting the following technical solution:

[0007] A composition with a skin barrier repair function, comprising the following components in parts by weight:

[0008] 20 - 40 parts of efficacy microcapsules;

[0009] 10 - 15 parts of Isatis indigotica extract;

[0010] 3 - 5 parts of hydrolyzed Abelmoschus esculentus extract;

[0011] The core material of the functional microcapsule includes ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:(1.5 - 3):(0.8 - 1.5).

[0012] By adopting the above technical solution, using the microcapsule technology to encapsulate ceramide, vegetable oil and sterol can improve the stability of the functional substances in the core material, and has a slow - release effect, which can continuously release ceramide, vegetable oil and sterol, thus prolonging the effective action time of the functional microcapsule.

[0013] Among them, ceramide can help thicken the stratum corneum, enhance the skin's tolerance, resist external stimuli, play a natural skin protection role, keep the skin barrier intact, and can repair sensitive skin such as flushing, and can quickly restore the skin's moisturizing and barrier functions. Vegetable oil contains various unsaturated fatty acids and natural active substances essential for the human body, is close to the structure of the human sebum membrane, is more easily absorbed by the skin than water, and has better permeability, so it can deeply penetrate and nourish the skin. In this application, by compounding ceramide and vegetable oil and adding sterol as the core material components together, the three play a better role in synergistically moisturizing and repairing sensitive skin, thereby improving the soothing and repairing effects of the composition on the skin.

[0014] Isatis indigotica extract has the effects of sterilization and anti - inflammation, can balance the skin flora, enhance skin resistance, and at the same time has a moisturizing effect, is suitable for moisturizing care of sensitive skin, and has a certain soothing and repairing effect on the skin. Hydrolyzed Abelmoschus esculentus extract has the effects of moisturizing and promoting collagen production. Although the skin repair effect is weak when used alone, when compounded with Isatis indigotica extract, it can further improve the soothing and skin - repairing effects of Isatis indigotica extract.

[0015] By compounding and using the functional microcapsule, Isatis indigotica extract and hydrolyzed Abelmoschus esculentus extract together, rapid moisturizing and long - acting moisturizing can be achieved simultaneously, greatly improving the soothing and repairing effects on the skin.

[0016] Preferably, the weight ratio of ceramide, vegetable oil and sterol is 1:(1.5 - 2):(1 - 1.2).

[0017] By adopting the above technical solution, when the weight ratio of ceramide, vegetable oil and sterol is within the above range, the synergistic effect of the three in moisturizing and repairing sensitive skin is better.

[0018] Preferably, the ceramide includes one or more of ceramide EOP, ceramide NS, ceramide NG and ceramide NP.

[0019] Preferably, the sterol is phytosterol, including one or more of β-sitosterol, stigmasterol, campesterol, and brassicasterol.

[0020] Preferably, the vegetable oil is selected from one or more of avocado oil, Limnanthes alba seed oil, evening primrose oil, peony seed oil, camellia seed oil, jojoba seed oil, macadamia seed oil, Rosa canina fruit oil, and castor oil.

[0021] By adopting the above technical solution, the above vegetable oil components can inhibit the evaporation of skin moisture, prevent skin chapping, and can fully exert the synergistic effect with ceramide and sterol, thereby improving the soothing and skin-repairing efficacy of the composition.

[0022] Preferably, the vegetable oil is composed of peony seed oil and macadamia seed oil in a weight ratio of 1:(0.2 - 0.4).

[0023] By adopting the above technical solution, peony seed oil contains components such as carotene and natural antioxidants. After being applied to the skin surface, it can not only play a role in cleaning the skin, but also be beneficial to promoting skin repair and has the effect of nourishing and caring for the skin. The fatty acid components of macadamia seed oil mainly include oleic acid, palmitoleic acid, and palmitic acid, with good stability and good skin permeability, and excellent moisturizing effect.

[0024] In the process of implementing the technical solution of the present application, it is found that when peony seed oil and macadamia seed oil are used simultaneously, the soothing and repair effects of the composition are better. On this basis, by optimizing the ratio of peony seed oil and macadamia seed oil, the use effect of the composition is further improved.

[0025] Preferably, the wall material of the functional microcapsule includes one or more of chitosan, sodium alginate, cyclodextrin, gum arabic, and gelatin.

[0026] Preferably, the functional microcapsule includes:

[0027] Core material;

[0028] Inner wall, the inner wall is coated on the outside of the core material, and the base material of the inner wall is β-cyclodextrin;

[0029] Outer wall, the outer wall is coated on the outside of the inner wall, and the base material of the outer wall is gum arabic.

[0030] By adopting the above technical solution, using a multi-layer coating technology, β-cyclodextrin and gum arabic are used to embed the core material in sequence, further improving the slow-release effect of the functional microcapsule, effectively improving the utilization rate of the active substance of the core material, and cooperating with Isatis tinctoria extract and hydrolyzed Abelmoschus esculentus extract, making the composition have good soothing and repair effects and the effects are long-lasting.

[0031] Preferably, the preparation method of the functional microcapsules comprises the following steps:

[0032] a. Add the core material into the ethanol solution of β-cyclodextrin, and stir to obtain monolayer capsules;

[0033] b. Mix the monolayer capsules, non-ionic surfactant, polyol, and sodium alginate, and then add them into the aqueous solution of gum arabic, and stir to obtain the functional microcapsules.

[0034] By adopting the above technical solution, during the preparation process of the microcapsules, using a non-ionic surfactant as the emulsifier and sodium alginate and polyol as the co-emulsifiers is beneficial to improving the biocompatibility between the monolayer capsules and gum arabic, thus successfully preparing the functional microcapsules with a bilayer structure and good stability.

[0035] Preferably, the weight ratio of the core material to β-cyclodextrin is 1:(2 - 2.5).

[0036] Preferably, the weight ratio of the monolayer capsules, non-ionic surfactant, polyol, and sodium alginate is 1:(0.4 - 0.6):(0.2 - 0.3):(0.1 - 0.2).

[0037] Preferably, the weight ratio of the monolayer capsules to gum arabic is 1:(1.2 - 1.5).

[0038] In a second aspect, the present application provides the use of the above composition having a skin barrier repair function in the preparation of a topical skin agent.

[0039] Preferably, the dosage form of the topical skin agent includes creams, lotions, aqueous solutions, essences, masks, and gels.

[0040] Preferably, in the topical skin agent, the content of the composition having a skin barrier repair function is 0.1 - 50 wt%.

[0041] In summary, the present application has at least the following beneficial effects:

[0042] 1. In the present application, ceramides, vegetable oils, and sterols are compounded, and the three play a good synergistic role in moisturizing and repairing sensitive skin, improving the soothing and repairing effects on the skin. Moreover, by encapsulating ceramides, vegetable oils, and sterols, a sustained release effect of the active ingredients is achieved, thereby prolonging the action time of the functional microcapsules;

[0043] 2. The isatis root extract in the present application has certain soothing and repairing effects on the skin. And by adding the hydrolyzed abelmoschus esculentus extract, the hydrolyzed abelmoschus esculentus extract has a certain promoting effect on the isatis root extract, further improving the soothing and skin-repairing effects of the isatis root extract;

[0044] 3. The method of the present application can achieve rapid hydration and long-term hydration effects by compounding the functional microcapsules, the isatis indigotica extract and the hydrolyzed coffee sunflower extract, thereby greatly improving the soothing and repairing effects on the skin;

[0045] 4. The vegetable oil of the present application is preferably composed of a compound of peony seed oil and macadamia seed oil. Experiments have found that the compound of peony seed oil and macadamia seed oil can further improve the soothing and repairing effects of the composition. DETAILED DESCRIPTION

[0046] The present application is further described in detail below in conjunction with embodiments.

[0047] The raw materials used in the examples of the present application are commercially available except for the following special instructions.

[0048] Preparation example of functional microcapsules

[0049] Preparation Example 1

[0050] A functional microcapsule, whose wall material is beta-cyclodextrin, and whose core material is ceramide, vegetable oil and sterol, wherein the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8.

[0051] The preparation method of the functional microcapsule is as follows:

[0052] Dissolve 100 g of cyclodextrin (β-cyclodextrin) in 2 L of ethanol solution with a mass concentration of 30% to obtain an ethanol solution of β-cyclodextrin;

[0053] 100 g of ceramide (ceramide NP), 150 g of vegetable oil (avocado oil) and 80 g of sterol (β-sitosterol) were mixed thoroughly to obtain a core material mixture;

[0054] Take 50 g of the core material mixture and put it into an ethanol solution of β-cyclodextrin, stir it at 600 r / min for 2 h using a magnetic stirrer, and spray dry it to obtain functional microcapsules.

[0055] Preparation Example 2

[0056] A functional microcapsule, whose wall material is beta-cyclodextrin, and whose core material is ceramide, vegetable oil and sterol, wherein the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:1.

[0057] The preparation method of the functional microcapsule is different from that of Preparation Example 1 in that 100 g of ceramide (ceramide NP), 150 g of vegetable oil (avocado oil) and 100 g of sterol (β-sitosterol) are fully mixed to obtain a core material mixture.

[0058] Preparation Example 3

[0059] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:2:1.

[0060] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 200 g of vegetable oil (shea butter) and 100 g of sterol (β-sitosterol) are mixed thoroughly to obtain a core material mixture.

[0061] Preparation Example 4

[0062] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:1.2.

[0063] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 150 g of vegetable oil (shea butter) and 120 g of sterol (β-sitosterol) are mixed thoroughly to obtain a core material mixture.

[0064] Preparation Example 5

[0065] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:2:1.2.

[0066] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 200 g of vegetable oil (shea butter) and 120 g of sterol (β-sitosterol) are mixed thoroughly to obtain a core material mixture.

[0067] Preparation Example 6

[0068] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:3:1.5.

[0069] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 300 g of vegetable oil (shea butter) and 150 g of sterol (β-sitosterol) are mixed thoroughly to obtain a core material mixture.

[0070] Preparation Example 7

[0071] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8.

[0072] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 150 g of vegetable oil (peony seed oil), and 80 g of sterol (β-sitosterol) are fully mixed to obtain a core material mixture.

[0073] Preparation Example 8

[0074] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8.

[0075] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 150 g of vegetable oil (macadamia nut oil), and 80 g of sterol (β-sitosterol) are fully mixed to obtain a core material mixture.

[0076] Preparation Example 9

[0077] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8.

[0078] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 150 g of vegetable oil (including 50 g of Limnanthes alba seed oil and 100 g of castor oil), and 80 g of sterol (β-sitosterol) are fully mixed to obtain a core material mixture.

[0079] Preparation Example 10

[0080] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8.

[0081] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP, sourced from Shenzhen Aichun Biology), 150 g of vegetable oil (including 125 g of peony seed oil and 25 g of macadamia nut oil), and 80 g of sterol (β-sitosterol) are fully mixed to obtain a core material mixture.

[0082] Preparation Example 11

[0083] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8.

[0084] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 150 g of vegetable oil (including 115 g of peony seed oil and 35 g of macadamia seed oil), and 80 g of sterol (β-sitosterol) are fully mixed to obtain a core material mixture.

[0085] Preparation Example 12

[0086] A functional microcapsule, whose wall material is β-cyclodextrin and core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8.

[0087] The preparation method of this functional microcapsule is different from that of Preparation Example 1 in that: 100 g of ceramide (ceramide NP), 150 g of vegetable oil (including 107 g of peony seed oil and 43 g of macadamia seed oil), and 80 g of sterol (β-sitosterol) are fully mixed to obtain a core material mixture.

[0088] Preparation Example 13

[0089] A functional microcapsule, which includes:

[0090] A core material, the core material is ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:1.5:0.8;

[0091] An inner wall, the inner wall is coated on the outside of the core material, and the base material of the inner wall is β-cyclodextrin;

[0092] An outer wall, the outer wall is coated on the outside of the inner wall, and the base material of the outer wall is gum arabic.

[0093] The preparation method of this functional microcapsule is as follows:

[0094] Dissolve 100 g of cyclodextrin (β-cyclodextrin) in 2 L of an ethanol solution with a mass concentration of 30% to obtain an ethanol solution of β-cyclodextrin;

[0095] Fully mix 100 g of ceramide (ceramide NP), 150 g of vegetable oil (including 115 g of peony seed oil and 35 g of macadamia seed oil), and 80 g of sterol (β-sitosterol) to obtain a core material mixture;

[0096] Take 50 g of the core material mixture and put it into the ethanol solution of β-cyclodextrin. Use a magnetic stirrer to stir for 2 h under the condition of 600 r / min, and then spray dry to obtain monolayer capsules;

[0097] After mixing 100 g of single-layer capsules, 40 g of non-ionic surfactant (Tween-20), 20 g of polyol (glycerol), and 10 g of sodium alginate, add them to an aqueous solution of gum arabic (obtained by mixing 120 g of gum arabic with 2 L of distilled water), stir at 800 r / min for 3 h, and then spray dry to obtain the functional microcapsules.

[0098] Preparation Example 14

[0099] A kind of functional microcapsule, which is different from Preparation Example 13 only in that during preparation, 40 g of core material mixture is taken and added to an ethanol solution of β-cyclodextrin, and stirred with a magnetic stirrer at 600 r / min for 2 h, and then spray dried to obtain single-layer capsules.

[0100] Preparation Example 15

[0101] A kind of functional microcapsule, which is different from Preparation Example 13 only in that during preparation, 100 g of single-layer capsules, 50 g of non-ionic surfactant (Tween-20), 25 g of polyol (glycerol), and 15 g of sodium alginate are mixed and then added to an aqueous solution of gum arabic (obtained by mixing 120 g of gum arabic with 2 L of distilled water), stirred at 800 r / min for 3 h, and spray dried to obtain the functional microcapsules.

[0102] Preparation Example 16

[0103] A kind of functional microcapsule, which is different from Preparation Example 13 only in that during preparation, 100 g of single-layer capsules, 60 g of non-ionic surfactant (Tween-20), 30 g of polyol (glycerol), and 20 g of sodium alginate are mixed and then added to an aqueous solution of gum arabic (obtained by mixing 120 g of gum arabic with 2 L of distilled water), stirred at 800 r / min for 3 h, and spray dried to obtain the functional microcapsules.

[0104] Preparation Example 17

[0105] A kind of functional microcapsule, which is different from Preparation Example 15 only in that during preparation, 100 g of single-layer capsules, 50 g of non-ionic surfactant (Tween-20), 25 g of polyol (glycerol), and 15 g of sodium alginate are mixed and then added to an aqueous solution of gum arabic (obtained by mixing 150 g of gum arabic with 2 L of distilled water), stirred at 800 r / min for 3 h, and spray dried to obtain the functional microcapsules.

[0106] In addition, when preparing the functional microcapsules with reference to Preparation Example 13, the weight ratio of the core material to β-cyclodextrin can also be 1:1, 1:1.5, 1:2.2, 1:3, etc. However, as known from performance tests, when the weight ratio of the core material to β-cyclodextrin is in the range of 1:(2 - 2.5), the performance of the obtained functional microcapsules is the best; the weight ratio of the single-layer capsules, non-ionic surfactant, polyol, and sodium alginate can also be 1:0.3:0.1:0.1, 1:0.4:0.1:0.05, 1:0.4:0.2:0.05, 1:0.7:0.4:0.3, etc. However, as known from performance tests, when the weight ratio of the single-layer capsules, non-ionic surfactant, polyol, and sodium alginate is in the range of 1:(0.4 - 0.6):(0.2 - 0.3):(0.1 - 0.2), the performance of the obtained functional microcapsules is the best; the weight ratio of the single-layer capsules to gum arabic can also be 1:1, 1:1.3, 1:2, etc. However, as known from performance tests, when the weight ratio of the single-layer capsules to gum arabic is in the range of 1:(1.2 - 1.5), the performance of the obtained functional microcapsules is the best.

[0107] Examples of the composition having a skin barrier repair function

[0108] Example 1

[0109] A composition having a skin barrier repair function, each component and its corresponding weight are shown in Table 1, and it is obtained by mechanical stirring.

[0110] Examples 2 - 5

[0111] A composition having a skin barrier repair function, which is different from Example 1 in that each component and its corresponding weight are shown in Table 1.

[0112]

[0113] Table 1 Components and their weights (g) in Examples 1 - 5

[0114] Examples 6 - 21

[0115] A composition having a skin barrier repair function, which is different from Example 3 only in that the usage of the functional microcapsules is different, and the specific usage is shown in Table 2.

[0116] Group Functional microcapsule Group Functional microcapsule Example 6 Functional microcapsule prepared in Preparation Example 2 Example 14 Functional microcapsule prepared in Preparation Example 10 Example 7 Functional microcapsule prepared in Preparation Example 3 Example 15 Functional microcapsule prepared in Preparation Example 11 Example 8 Functional microcapsule prepared in Preparation Example 4 Example 16 Functional microcapsule prepared in Preparation Example 12 Example 9 Functional microcapsule prepared in Preparation Example 5 Example 17 Functional microcapsule prepared in Preparation Example 13 Example 10 Functional microcapsule prepared in Preparation Example 6 Example 18 Functional microcapsule prepared in Preparation Example 14 Example 11 Functional microcapsule prepared in Preparation Example 7 Example 19 Functional microcapsule prepared in Preparation Example 15 Example 12 Functional microcapsule prepared in Preparation Example 8 Example 20 Functional microcapsule prepared in Preparation Example 16 Example 13 Functional microcapsule prepared in Preparation Example 9 Example 21 Functional microcapsule prepared in Preparation Example 17

[0117] Table 2 Usage of the functional microcapsules in Examples 6 - 21

[0118] Comparative example

[0119] Comparative Examples 1 - 4

[0120] A composition, which is different from that of Example 1 in that the components and their corresponding weights are shown in Table 3.

[0121]

[0122] Table 3 Components and weights (g) of each component in Example 1 and Comparative Examples 1-4

[0123] Comparative Examples 5-7

[0124] A composition, which is different from that of Example 1 in that the components of the efficacy microcapsule core material and their corresponding weights are shown in Table 4.

[0125]

[0126]

[0127] Table 4 Components and weights (g) of the efficacy microcapsule core material in Example 1 and Comparative Examples 1-4

[0128] Application Examples

[0129] Skin topical agents (emulsions) were prepared using the compositions of Examples 1-21 and Comparative Examples 1-7 respectively:

[0130] According to the ratio of 20 wt% composition, 5 wt% glycerol, 0.1 wt% xanthan gum, 3 wt% butanediol, 0.5 wt% glyceryl stearate, 0.5 wt% cetearyl alcohol and 70.9 wt% deionized water, mechanical stirring and mixing were carried out to obtain an emulsion.

[0131] It should be noted that in this application example, only the emulsion is taken as an example for a brief description. However, in other application examples, the dosage forms of the skin topical agents can also be creams, aqueous solutions, essences, masks and gels.

[0132] Performance Detection Tests

[0133] Skin Barrier Repair Performance Test

[0134] Test materials: Emulsions prepared from the compositions of Examples 1-21 and Comparative Examples 1-7 in the application examples;

[0135] Test subjects: 140 volunteers with moderately sensitive skin (total questionnaire score of 24-32 points) aged 25-30 years were selected according to the Huaxi Questionnaire for Sensitive Skin;

[0136] Test method: The volunteers were randomly divided into 28 groups (5 people in each group), and the emulsions prepared from the compositions of Examples 1-21 and Comparative Examples 1-7 in the application examples were used for testing. The volunteers in the same group used the same emulsion. The emulsion was applied to the face at 8:00 am and 8:00 pm every day for 14 consecutive days. The TEWL (trans-epidermal water loss) value, moisture content, heme and erythema value of the volunteers' faces were measured on the 0th day and the 14th day respectively. Based on the data on the 0th day, the data on the 14th day was compared with the benchmark to reflect the change in data before and after use;

[0137] Detection instruments: Tewameter TM300 (for measuring TEWL value), Corneometer CM825 (for measuring moisture content), Mexameter MX18 (for measuring heme and erythema value);

[0138] Calculation method:

[0139] Change in TEWL value = (TEWL value on the 14th day - TEWL value on the 0th day) / TEWL value on the 0th day;

[0140] Change in moisture content = (moisture content on the 14th day - moisture content on the 0th day) / moisture content on the 0th day;

[0141] Improvement in heme = (heme content on the 0th day - heme content on the 14th day) / heme content on the 0th day;

[0142] Improvement in erythema value = (erythema value on the 0th day - erythema value on the 14th day) / erythema value on the 0th day;

[0143] Test results: The average value was taken within the same group and recorded in Table 5 below.

[0144]

[0145]

[0146] Table 5 Performance test results

[0147] It can be seen from the data in Table 5 that the compositions of Examples 1-21 of the present application have better effects of soothing and repairing the skin compared with Comparative Examples 1-7.

[0148] Combined with Example 1 and Comparative Examples 1-4, and combined with the data in Table 5, it can be seen that the isatis root extract and hydrolyzed abelmoschus esculentus extract used in the composition formula can play a better synergistic promoting effect, and can further improve the soothing and skin repair effect of the composition.

[0149] Combined with Example 1 and Comparative Examples 5-7, and combined with the data in Table 5, it can be seen that in the present application, by compounding ceramide, vegetable oil and sterol as the core material components of the functional microcapsules, the three play a better synergistic effect in moisturizing and repairing sensitive skin, improving the soothing and repairing effects on the skin.

[0150] Combined with Example 3 and Examples 6-10, and combined with the data in Table 5, it can be seen that when the core material of the functional microcapsules is composed of ceramide, vegetable oil and sterol in a weight ratio of 1:(1.5-2):(1-1.2), the obtained composition has better performance.

[0151] Combined with Example 3 and Examples 11-16, and combined with the data in Table 5, it can be seen that when peony seed oil and macadamia seed oil are used in combination, they can play a better synergistic effect and further improve the soothing and skin repairing effects of the composition.

[0152] This specific embodiment is only an explanation of the present application, and it does not limit the present application. Those skilled in the art can make modifications without creative contributions to this embodiment according to needs after reading this specification, but as long as it is within the scope of the claims of the present application, it is protected by the patent law.

Claims

1. A composition with skin barrier repair function, characterized in that, it comprises the following components in parts by weight: Functional microcapsules 20 - 40 parts; Isatis indigotica extract 10 - 15 parts; Hydrolyzed okra extract 3 - 5 parts; The core material of the functional microcapsules comprises ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:(1.5 - 3):(0.8 - 1.5); The functional microcapsules include: Core material; Inner wall, the inner wall is coated on the outside of the core material, and the base material of the inner wall is β-cyclodextrin; Outer wall, the outer wall is coated on the outside of the inner wall, and the base material of the outer wall is gum arabic; The preparation method of the functional microcapsules comprises the following steps: a. Add the core material into the ethanol solution of β-cyclodextrin, stir to obtain monolayer capsules; b. Mix the monolayer capsules, non-ionic surfactant, polyol and sodium alginate, and then add them into the aqueous solution of gum arabic, stir to obtain functional microcapsules.

2. The composition with skin barrier repair function according to claim 1, characterized in that, the weight ratio of ceramide, vegetable oil and sterol is 1:(1.5 - 2):(1 - 1.2).

3. The composition with skin barrier repair function according to claim 1 or 2, characterized in that, the vegetable oil is selected from one or more of avocado oil, Limnanthes alba seed oil, evening primrose oil, peony seed oil, camellia seed oil, jojoba seed oil, macadamia seed oil, Rosa canina fruit oil and castor seed oil.

4. The composition with skin barrier repair function according to claim 3, characterized in that, the vegetable oil is composed of peony seed oil and macadamia seed oil in a weight ratio of 1:(0.2 - 0.4).

5. The composition with skin barrier repair function according to claim 1, characterized in that, the weight ratio of the core material to β-cyclodextrin is 1:(2 - 2.5).

6. The composition with skin barrier repair function according to claim 1, characterized in that, the weight ratio of the monolayer capsules, non-ionic surfactant, polyol and sodium alginate is 1:(0.4 - 0.6):(0.2 - 0.3):(0.1 - 0.2).

7. The composition with skin barrier repair function according to claim 1, characterized in that, the weight ratio of the monolayer capsules to gum arabic is 1:(1.2 - 1.5).

8. Use of the composition with skin barrier repair function according to any one of claims 1 - 7 in the preparation of skin topical agents.

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