A kind of biomass antibacterial and hemostatic non-woven fabric and its functionalization method

Abstract

A biomass antibacterial and hemostatic non-woven fabric and its functionalization method, which relate to the technical field of textile functional finishing. The functionalization method of the present invention is as follows: The cellulose-based non-woven fabric is treated by double dipping and double rolling with a sodium alginate solution, and then a high-temperature curing is carried out to form an anionic layer film. Then, it is treated by double dipping and double rolling with a mixed solution of chitosan and biguanide substances, and a cationic layer film is formed after a primary cross-linking by electrostatic interaction and hydrogen bonds. Subsequently, it is immersed in a calcium chloride solution, and a secondary cross-linking is carried out by the chelation of the carboxylate anions of sodium alginate and calcium ions. The biguanide substances and chitosan in the cationic layer are used to synergistically inhibit bacteria, and the release of calcium ions and the cationic outer layer of chitosan are used to synergistically stimulate blood coagulation factors and aggregate platelets to stop bleeding, thereby constructing a natural and safe biomass antibacterial and hemostatic cellulose-based non-woven fabric, which can be adapted to production and is green and safe.

Description

Technical Field

[0001] The present invention relates to the technical field of textile functional finishing, and particularly relates to a biomass antibacterial and hemostatic non-woven fabric and its functionalization method. Background Art

[0002] When an open wound appears on the skin surface, as a physical protection barrier of the human body, functional sanitary textiles play a significant role in protection and promoting wound healing. Such products have great potential for development and application. The spunlace non-woven fabric production process is simple and low-cost. Used in disposable sanitary products, it can effectively prevent the spread of bacteria and viruses and, to a certain extent, prevent the flow of exudate, making it a good raw material for medical gauze and bandages. Among the three major antibacterial agents, inorganic antibacterial agents such as metal and its oxide nanoparticles have excellent antibacterial effects, low production costs, and wide applications. For example, the Chinese utility model patent with the publication number CN209951562U discloses a silver ion alginate wound antibacterial dressing, which uses silver ions to achieve high-efficiency antibacterial. However, metal particles such as silver ions have potential cytotoxicity, and long-term contact with wounds may affect cell growth. Most organic synthetic antibacterial agents are mainly antibiotics. The abuse of antibiotics has led to the emergence of bacterial drug resistance, and most antibiotics are small molecules with sudden release, making it difficult to achieve continuous antibacterial effects.

[0003] Natural antibacterial agents are rich in sources, natural non-toxic, and have high safety, making them a bio-friendly antibacterial agent. Chitosan has been widely used in biomedical and functional textiles due to its unique properties such as natural cationicity, biocompatibility, and inherent antibacterial properties. Chitosan can stimulate immune cells to release inflammatory factors, accelerate wound healing, and promote tissue growth, showing great potential in the field of new medical materials. Sodium alginate, as the only anionic polysaccharide in nature, is widely used in the processing of hemostatic materials due to its good biocompatibility, viscosity, and hygroscopicity. For example, the Chinese invention patent with the publication number CN110522945B discloses a medical bio-gel hemostatic dressing and its preparation method, which uses calcium alginate and polyvinyl alcohol to form a gel-like hemostatic material. Most of the existing technologies are for preparing gel-like hemostatic materials and coagulation nanoparticles. Although gauze, as a traditional hemostatic material with low price and wide use, is often limited in its application due to its lack of functionality. Therefore, developing a type of functional non-woven fabric to replace ordinary gauze has economic benefits and application prospects. Summary of the Invention

[0004] Technical problems to be solved: Aiming at the technical problems existing in the prior art, the present invention proposes a biomass antibacterial and hemostatic non-woven fabric and its functionalization method. The prepared non-woven fabric can adapt to production and has the advantages of being green, safe, antibacterial, and hemostatic.

[0005] Technical solution: A functionalization method of a biomass antibacterial and hemostatic non-woven fabric, the steps are as follows:

[0006] S1. Pretreatment: The cellulose-based non-woven fabric is obtained by alkali boiling for degreasing, neutralizing and rinsing, and the cellulose-based non-woven fabric with impurities removed is obtained;

[0007] S2. Construction of the anionic base layer: The cellulose-based non-woven fabric obtained by the pretreatment described in S1 is placed in the finishing solution 1 at 60 °C, and after double dipping and double rolling, it is cured at high temperature. The finishing solution 1 is a sodium alginate solution with a concentration of 0.2-0.4 wt%, and the viscosity is 200±20 mPa·s. Sodium alginate has the advantages of biological safety, wide source and green renewable. It adheres to the cellulose-based non-woven fabric by virtue of its film-forming property, and the viscosity should be selected appropriately. Too high viscosity will lead to a thicker film, affecting the hand feeling and air permeability;

[0008] S3. Primary cross-linking: The cellulose-based non-woven fabric described in S2 is placed in the finishing solution 2 at 60 °C, and after double dipping and double rolling, it is cured at high temperature. The finishing solution 2 is a mixed solution of chitosan and polyhexamethylene biguanide hydrochloride, and the mixing volume ratio is 85:15, and the concentration is 0.2-0.4 wt%. Chitosan and polyhexamethylene biguanide are cationic antibacterial substances, and they are combined with the carboxylate anions of sodium alginate through electrostatic interaction. Among them, the molecular weight and deacetylation degree of chitosan are selected to be about 50 kDa and 90%, and at this time, the antibacterial effect of chitosan is better;

[0009] S4. Secondary cross-linking: The cellulose-based non-woven fabric described in S3 is immersed in a calcium chloride solution, and secondary cross-linking is carried out by the chelation of calcium ions and the carboxylate anions of sodium alginate. After sufficient washing with water, it is dried at 80 °C to obtain the antibacterial and hemostatic spunlace fabric.

[0010] Preferably, the cellulose-based non-woven fabric in the step S1 is a medium-thick spunlace fabric formed by pure spinning or blending of cotton fiber and viscose fiber. Compared with ordinary degreased gauze, the spunlace fabric has the characteristics of short process and high efficiency production, and can take into account the blood absorption ability and air permeability and moisture permeability.

[0011] Preferably, the grammage of the cellulose-based non-woven fabric in the step S1 is 60-90 g / m 2 , too low grammage results in too thin thickness, resulting in insufficient blood absorption and hemostasis ability, and cannot meet the need for immediate hemostasis; too high grammage results in too thick thickness, affecting air permeability and moisture permeability, and poor air permeability of the wound will lead to the generation of new inflammation and affect healing.

[0012] Preferably, when the cellulose-based non-woven fabric is degreased by alkali boiling in the step S1, the alkali boiling solution is an aqueous solution containing 0.2-0.4 wt% sodium hydroxide, 0.4-0.8 wt% sodium dodecyl sulfonate and 0.4-0.8 wt% sodium carbonate. Alkali boiling is used for degreasing to remove most impurities, the treatment time is 15 min, and it is neutralized and washed with a 0.3 wt% sulfuric acid solution, and then washed twice with water and reserved.

[0013] Preferably, in the finishing processes of steps S2 and S3, the liquor ratio is 1:20, the vehicle speed is 15 m / min, and the expression rate is 80-90%.

[0014] Preferably, in steps S2 and S3, high-temperature curing is performed by a combined drying method of hot air and heat conduction. The drying temperature is controlled at 120-130 °C, and the drying time is controlled at 120-150 s. The drying temperature and time should be strictly controlled to avoid yellowing of the fabric surface.

[0015] Preferably, in step S4, the concentration of the calcium chloride solution is 1 wt%, the liquor ratio is 1:20, the vehicle speed is 10 m / min, and the expression rate is 100-110%.

[0016] A biomass antibacterial and hemostatic non-woven fabric prepared by the above functionalization method of a biomass antibacterial and hemostatic non-woven fabric. The non-woven fabric has a white appearance and has good air permeability and moisture permeability effects.

[0017] In the present invention, after the cellulose-based non-woven fabric is subjected to double dipping and double rolling treatment with a sodium alginate solution, an anion layer film is formed by high-temperature curing. Then, after double dipping and double rolling treatment with a mixed solution of chitosan and biguanide substances, a cation layer film is formed by primary cross-linking through electrostatic interaction and hydrogen bonding. Subsequently, it is immersed in a calcium chloride solution, and secondary cross-linking is carried out by the chelation of the carboxylate anions of sodium alginate and calcium ions. The biguanide substances and chitosan in the cation layer are used synergistically for antibacterial, and the release of calcium ions and the cation outer layer of chitosan are used to stimulate coagulation factors and aggregate platelets synergistically for hemostasis, thereby constructing a natural and safe biomass antibacterial and hemostatic cellulose-based non-woven fabric.

[0018] Beneficial effects: The present invention provides a cellulose-based non-woven fabric with convenient production, green safety, antibacterial, and hemostatic properties based on biomass. Compared with the prior art, the beneficial effects of the present invention are as follows:

[0019] (1) The present invention uses a non-woven spunlace fabric as the base material. Compared with traditional degreased hemostatic gauze, the long weaving process is omitted to speed up the production speed. Compared with new gel-based hemostatic materials, the cost is relatively low and it has the advantage of large-scale production.

[0020] (2) The present invention uses natural biomass as a finishing agent. The non-woven fabric obtained after finishing has the advantages of high biosafety and environmental friendliness, meeting the production requirements of green, natural, renewable, and degradable.

[0021] (3) The non-woven fabric formed by the present invention has a broad-spectrum and highly efficient antibacterial effect. Due to the synergistic antibacterial effect of the cations of chitosan and biguanide, the bactericidal effects on Gram-positive bacteria and Gram-negative bacteria reach 99.99% and 96% within 30 min.

[0022] (4) The non-woven fabric formed by the present invention has good hemostatic and blood coagulation properties. Thanks to the aggregation of red blood cells and platelets by the cationic outer layer and the release of calcium ions to activate blood coagulation factors, the blood coagulation index (BCI value) reaches 47%. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is the antibacterial effect diagram of the antibacterial and hemostatic non-woven fabric of the present invention;

[0024] Figure 2 It is the hemostatic effect diagram of the antibacterial and hemostatic non-woven fabric of the present invention;

[0025] Figure 3 It is the scanning electron microscope and element analysis diagram of the antibacterial and hemostatic non-woven fabric of the present invention. Figure (a) is the scanning electron microscope diagram with a scale of 100 um, Figure (b) is the scanning electron microscope diagram with a scale of 20 um, and Figure (c) is the element analysis diagram;

[0026] Figure 4 It is the air permeability and moisture permeability diagram of the antibacterial and hemostatic non-woven fabric of the present invention. Figure (a) is the air permeability diagram, and Figure (b) is the moisture permeability diagram;

[0027] Figure 5 It is the physical diagram of the antibacterial and hemostatic non-woven fabric of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0028] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0029] In the embodiments of the specification of the present invention, the raw materials used are all ordinary commercially available products unless otherwise specified. Among them, the pure cotton spunlace fabric and the cotton-viscose spunlace fabric are both purchased from Fujian Funeng Nanfang Sanitary Materials Co., Ltd.; chitosan is purchased from Macklin Biotech Co., Ltd., the molecular weight of chitosan is 50 kDa, and the degree of deacetylation is 90%; sodium alginate and calcium chloride are purchased from Sinopharm Chemical Reagent Co., Ltd.

[0030] When neutralizing and pickling, a 0.3 wt% sulfuric acid solution is used for neutralizing and cleaning.

[0031] Example 1

[0032] A biomass antibacterial and hemostatic non-woven fabric and its functionalization method specifically include the following steps: (1) Pretreatment: Pure cotton spunlace fabric (60 g / m 2)The cellulose-based non-woven fabric is scoured and degreased with a mixed aqueous solution of 0.2 wt% sodium hydroxide, 0.4 wt% sodium dodecyl sulfonate and 0.4 wt% sodium carbonate for 15 min, and after neutralization and pickling, it is washed twice with water to remove surface impurities; (2) Construction of the anionic base layer: The cellulose-based non-woven fabric pretreated in step (1) is placed in a 0.2 wt% sodium alginate solution (liquor ratio 1:20) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 120 °C for 120 s; (3) Primary cross-linking: The cellulose-based non-woven fabric described in step (2) is placed in a mixed solution of 0.2 wt% chitosan and polyhexamethylene biguanide hydrochloride (volume ratio 85:15) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 120 °C for 120 s; (4) Secondary cross-linking: The cellulose-based non-woven fabric described in step three is immersed in a 1 wt% calcium chloride solution, and after sufficient washing with water, it is dried at 80 °C to obtain the antibacterial and hemostatic spunlace fabric.

[0033] Example 2

[0034] A biomass antibacterial and hemostatic non-woven fabric and its functionalization method specifically include the following steps: (1) Pretreatment: The cotton-viscose spunlace fabric (90 g / m 2 )The cellulose-based non-woven fabric is scoured and degreased with a mixed aqueous solution of 0.4 wt% sodium hydroxide, 0.8 wt% sodium dodecyl sulfonate and 0.8 wt% sodium carbonate for 15 min, and after neutralization and pickling, it is washed twice with water to remove surface impurities; (2) Construction of the anionic base layer: The cellulose-based non-woven fabric pretreated in step (1) is placed in a 0.4 wt% sodium alginate solution (liquor ratio 1:20) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 140 °C for 150 s; (3) Primary cross-linking: The cellulose-based non-woven fabric described in step (2) is placed in a mixed solution of 0.4 wt% chitosan and polyhexamethylene biguanide hydrochloride (volume ratio 85:15) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 140 °C for 150 s; (4) Secondary cross-linking: The cellulose-based non-woven fabric described in step three is immersed in a 1 wt% calcium chloride solution, and after sufficient washing with water, it is dried at 80 °C to obtain the antibacterial and hemostatic spunlace fabric.

[0035] Example 3

[0036] A biomass antibacterial and hemostatic non-woven fabric and its functionalization method specifically include the following steps: (1) Pretreatment: The pure cotton spunlace fabric (70 g / m 2)The degreasing and defatting are carried out by boiling in a mixed aqueous solution of 0.2 wt% sodium hydroxide, 0.6 wt% sodium dodecyl sulfonate and 0.6 wt% sodium carbonate for 15 min, and after neutralization and pickling, it is washed twice with water to remove surface impurities; (2) Construction of the anionic base layer: The cellulose-based non-woven fabric pretreated in step (1) is placed in a 0.2 wt% sodium alginate solution (liquor ratio 1:20) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 120 °C for 120 s; (3) Primary cross-linking: The cellulose-based non-woven fabric described in step two is placed in a mixed solution of 0.3 wt% chitosan and polyhexamethylene biguanide hydrochloride (volume ratio 85:15) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 120 °C for 150 s; (4) Secondary cross-linking: The cellulose-based non-woven fabric described in step three is immersed in a 1 wt% calcium chloride solution, and after sufficient washing with water, it is dried at 80 °C to obtain the antibacterial and hemostatic spunlace fabric. For the physical diagram, see Figure 5 。

[0037] Comparative Example 1

[0038] A biomass antibacterial and hemostatic non-woven fabric and its functionalization method specifically include the following steps: (1) Pretreatment: The pure cotton spunlace fabric (70 g / m 2 )The degreasing and defatting are carried out by boiling in a mixed aqueous solution of 0.2 wt% sodium hydroxide, 0.6 wt% sodium dodecyl sulfonate and 0.6 wt% sodium carbonate for 15 min, and after neutralization and pickling, it is washed twice with water to remove surface impurities; (2) Construction of the anionic base layer: The cellulose-based non-woven fabric pretreated in step (1) is placed in a 0.2 wt% sodium alginate solution (liquor ratio 1:20) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 120 °C for 120 s; (3) Primary cross-linking: The cellulose-based non-woven fabric described in step two is placed in a 0.3 wt% chitosan solution (liquor ratio 1:20) at 60 °C, and after double dipping and double rolling, it is cured at a high temperature of 120 °C for 150 s, and after sufficient washing with water, it is dried at 80 °C to obtain the antibacterial and hemostatic spunlace fabric.

[0039] Comparative Example 2

[0040] A biomass antibacterial and hemostatic non-woven fabric and its functionalization method specifically include the following steps: (1) Pretreatment: The pure cotton spunlace fabric (70 g / m 2)Degreasing and defatting were carried out for 15 min by boiling in a mixed aqueous solution of 0.2 wt% sodium hydroxide, 0.6 wt% sodium dodecyl sulfonate and 0.6 wt% sodium carbonate, and surface impurities were removed by secondary water washing after neutralization and pickling; (2) Construction of the anionic base layer: The cellulose-based non-woven fabric pretreated in step (1) was placed in a 0.2 wt% sodium alginate solution (bath ratio 1:20) at 60 °C, and after double dipping and double rolling, it was cured at a high temperature of 120 °C for 120 s; (3) Primary cross-linking: The cellulose-based non-woven fabric described in step two was placed in a mixed solution of 0.3 wt% chitosan and polyhexamethylene biguanide hydrochloride (volume ratio 85:15) at 60 °C, and after double dipping and double rolling, it was cured at a high temperature of 120 °C for 150 s, and after thorough water washing, it was dried at 80 °C to obtain the antibacterial and hemostatic spunlace fabric.

[0041] Comparative Example 3

[0042] A biomass antibacterial and hemostatic non-woven fabric and its functionalization method specifically include the following steps: (1) Pretreatment: The pure cotton spunlace fabric (70 g / m 2 )Degreasing and defatting were carried out for 15 min by boiling in a mixed aqueous solution of 0.2 wt% sodium hydroxide, 0.6 wt% sodium dodecyl sulfonate and 0.6 wt% sodium carbonate, and surface impurities were removed by secondary water washing after neutralization and pickling; (2) Construction of the cationic base layer: The cellulose-based non-woven fabric pretreated in step (1) was placed in a mixed solution of 0.3 wt% chitosan and polyhexamethylene biguanide hydrochloride (volume ratio 85:15) at 60 °C, and after double dipping and double rolling, it was cured at a high temperature of 120 °C for 120 s; (3) Primary cross-linking: The cellulose-based non-woven fabric described in step (2) was placed in a 0.2 wt% sodium alginate solution (bath ratio 1:20) at 60 °C, and after double dipping and double rolling, it was cured at a high temperature of 120 °C for 120 s; (4) Secondary cross-linking: The cellulose-based non-woven fabric described in step three was immersed in a 1 wt% calcium chloride solution, and after thorough water washing, it was dried at 80 °C to obtain the antibacterial and hemostatic spunlace fabric.

[0043] Refer to AATCC-100 《Anti-bacterial Assessment or Bacterial Resistance Teston textile Material》 to conduct antibacterial test analysis on the above examples and comparative examples. Three parallel samples were used for testing in each single experimental group. The antibacterial effects of the antibacterial and hemostatic non-woven fabrics in the examples and comparative examples are as Figure 1As shown, S.aureus - Staphylococcus aureus, a Gram-positive bacterium; E.coli - Escherichia coli, a Gram-negative bacterium. The antibacterial test results show that the bacteriostatic and hemostatic non-woven fabric of the examples has excellent bactericidal effects on Staphylococcus aureus and Escherichia coli, with the bacteriostatic rates reaching 99.99% (reaching the detection limit) and 96% within 30 minutes respectively. Compared with Comparative Example 1, the primary cross-linking process involving a small amount of polyhexamethylbiguanide can enhance the disinfection of the Gram-negative bacterium Escherichia coli by the non-woven fabric. Analyzing the reason, it may be that the relatively small molecules of polyhexamethylbiguanide can be released from the surface of the non-woven fabric and adsorb on the surface of Escherichia coli relying on its large positive potential, resulting in the death of Escherichia coli. The opposite assembly sequence leads to relatively poor bacteriostatic effects in Comparative Example 3. The surface of the bacterial cell wall is negatively charged, and the non-woven fabric obtained by the opposite assembly sequence shows a negative charge on its surface, resulting in poor adsorption ability of the non-woven fabric surface to bacteria, thus leading to a lower bacteriostatic rate than that of the examples with a cationic outer layer.

[0044] The blood coagulation and hemostasis ability is evaluated by the blood coagulation index (BCI), and the method is as follows: Cut the non-woven fabric into pieces of 1 cm×1 cm size and place them in a petri dish, preheat them in an incubator at 37 °C for 5 minutes, then drop 100 μL of fresh rabbit whole blood containing anticoagulant, immediately drop 10 μL of 0.2 M calcium chloride solution into it, incubate it in an incubator at 37 °C for 5 minutes, then inject 25 mL of PBS buffer without P into the petri dish, and shake it at a shaking speed of 30 rpm / min for 10 minutes to dissolve the unadhered and uncoagulated blood cells, and measure the ultraviolet absorption value of the blood cell solution at 542 nm. The BCI value of the sample is the ratio of the absorption value of the blood cell solution with the hemostatic material added to the absorption value of the blood cell solution of the control sample without the hemostatic material added. The blood coagulation indexes of the bacteriostatic and hemostatic non-woven fabrics of the examples and comparative examples are as Figure 2 shown. The negative control group is the blood group without adding hemostatic material, and the positive control group is the commercially available hemostatic gauze. The blood coagulation indexes of all examples reach below 47%. Compared with the examples, in Comparative Example 1 and Comparative Example 2, the calcium ion secondary cross-linking is not involved, and there is a lack of calcium ions to activate coagulation factors during the blood coagulation process, resulting in relatively poor blood coagulation effects, and the blood coagulation index only reaches 61%.

[0045] Through scanning electron microscopy (SEM) and X-ray energy dispersive spectrometer (EDS) analysis, the change in the microscopic morphology and the presence of calcium ions on the surface of the non-woven fabric after functional finishing were verified. Figure 3SEM scanning electron micrograph and EDS element distribution map of Example 3, where (a) is a microscopic image magnified 300 times, (b) is a microscopic image magnified 2000 times, and (c) is the element distribution map of the non-woven fabric. Refer to GB / T 3923.1-2013 "Textiles - Tensile properties of fabrics - Part 1: Determination of breaking force and elongation at break (strip method)" to test the tensile fracture properties of the non-woven fabric. The strength of each sample in the examples shows a certain increase compared to the unprocessed non-woven fabric, which depends on the hydrogen bond formation between the hydroxyl and amino groups of sodium alginate and chitosan and the hydroxyl groups of the cellulose-based non-woven fabric. Compared with the examples, the non-woven fabric of the comparative example has relatively weak strength due to the lack of secondary cross-linking of calcium ions. Refer to GB / T 5453-1997 "Textiles - Determination of air permeability of fabrics" and GB / T 12704.1—2009 "Textiles - Test method for moisture permeability of fabrics - Part 1: Moisture absorption method" to test the air permeability and moisture permeability of the non-woven fabric. The air permeability and moisture permeability of the antibacterial and hemostatic non-woven fabrics of the examples and the comparative example are as Figure 4 shown, (a) is the air permeability of the non-woven fabric, (b) is the moisture permeability of the non-woven fabric, and the blank sample is 70 g / m 2 cotton spunlace fabric. Compared with the unmodified non-woven fabric, the air permeability and moisture permeability do not show a significant decrease. The above results indicate that the non-woven fabric of the present invention has a good antibacterial and hemostatic effect and has the application prospect of a new fabric-based hemostatic material.

Claims

1. A functionalization method of a biomass antibacterial and hemostatic non-woven fabric, characterized in that, The steps are as follows: S1. Pretreatment: The cellulose-based non-woven fabric is obtained by alkali boiling and degreasing, neutralizing and rinsing to remove impurities; S2. Construction of the anionic base layer: The cellulose-based non-woven fabric obtained by the pretreatment in S1 is placed in the finishing solution 1 at 60 °C, and after double dipping and double rolling, it is cured at high temperature. The finishing solution 1 is a sodium alginate solution with a concentration of 0.2-0.4 wt%; S3. Primary cross-linking: The cellulose-based non-woven fabric in S2 is placed in the finishing solution 2 at 60 °C, and after double dipping and double rolling, it is cured at high temperature. The finishing solution 2 is a mixed solution of chitosan and polyhexamethylene biguanide hydrochloride, with a mixing volume ratio of 85:15 and a concentration of 0.2-0.4 wt%. The molecular weight of chitosan is 50 kDa and the degree of deacetylation is 90%; S4. Secondary cross-linking: The cellulose-based non-woven fabric in S3 is immersed in a calcium chloride solution, and after sufficient water washing, it is dried at 80 °C to obtain an antibacterial and hemostatic spunlace fabric; Among them, in the steps S2 and S3, high-temperature curing is carried out by a hot air heat conduction mixing drying method, the drying temperature is controlled at 120-130 °C, and the drying time is controlled at 120-150 s.

2. The functionalization method of a biomass antibacterial and hemostatic non-woven fabric according to claim 1, characterized in that, In the step S1, the cellulose-based non-woven fabric is a medium-thick spunlace fabric formed by pure spinning or blending of cotton fibers and viscose fibers.

3. The functionalization method of a biomass antibacterial and hemostatic non-woven fabric according to claim 2, characterized in that, The grammage of the cellulose-based non-woven fabric in the step S1 is 60-90 g / m 2 .

4. A method for functionalizing a biomass antibacterial and hemostatic non-woven fabric according to claim 1, characterized in that, When the cellulose-based non-woven fabric is alkali-boiled and degreased in the step S1, the alkali-boiling solution is an aqueous solution containing 0.2-0.4 wt% sodium hydroxide, 0.4-0.8 wt% sodium dodecyl sulfonate and 0.4-0.8 wt% sodium carbonate.

5. The functionalization method of a biomass antibacterial and hemostatic non-woven fabric according to claim 1, characterized in that, In the steps S2 and S3, the bath ratio of the finishing process is 1:20, the vehicle speed is 15 m / min, and the liquor pickup rate is 80-90%.

6. The functionalization method of a biomass antibacterial and hemostatic non-woven fabric according to claim 1, characterized in that, In the step S4, the concentration of the calcium chloride solution is 1 wt%, the bath ratio is 1:20, the vehicle speed is 10 m / min, and the liquor pickup rate is 100-110%.

7. A biomass antibacterial and hemostatic non-woven fabric prepared by the functionalization method of a biomass antibacterial and hemostatic non-woven fabric according to claim 1.

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