A plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects and its application

Abstract

The present invention discloses a plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects and its application. The plant composition comprises the following components by weight: 3-10 parts of emblica fruit extract, 0.15-0.60 parts of hibiscus leaf extract, 0.15-0.60 parts of euphorbia pulegosa extract, 1-8 parts of condiment osmanthus extract, 0.03-0.25 parts of asparagus cochinchinensis extract and 0.2-2.5 parts of hibiscus flower extract. The plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects is applied to shampoo, and the weight percentage of the plant composition in the shampoo is 2-13%. The present invention uses reasonable screening and scientific proportioning to make the components play a synergistic role, which can not only effectively inhibit Malassezia, solve the problems of dandruff and scalp itching, but also has the effects of anti-inflammatory and repairing the scalp barrier.

Description

Technical Field

[0001] The invention relates to the field of daily cosmetics, and in particular to a plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects and an application thereof. Background Art

[0002] Epidemiological research shows that the scalp of Chinese adults generally has health problems to varying degrees, among which dandruff is a common and frequent scalp disease. Hair is the first element of human beauty and an important standard of health. Having flowing hair is what every beauty lover desires. Excessive dandruff not only affects personal image and gives people an unhygienic feeling, but also often causes trouble when interacting with others, and even has a huge adverse impact on certain occupational groups, such as etiquette, models, etc.

[0003] At present, there are many types of dandruff and antipruritic shampoos on the market. The main antidandruff ingredients in antidandruff shampoos are chemical substances, such as zinc pyrithione (ZPT) and piroctone olamine (PO). Although they have strong bactericidal power and good immediate effect, they are highly irritating and can produce drug resistance. Long-term use and residues will destroy the metabolic balance of the scalp, cause inflammation and bacterial imbalance, and cause frequent scalp problems.

[0004] Natural plant anti-dandruff agents not only have excellent anti-dandruff and antibacterial effects, but are also safe, non-toxic and non-side-effect, and are more suitable for long-term use. With the popularity of environmental protection, low carbon, green and natural trends, although there are shampoos on the market that claim to be plant anti-dandruff, most of them are still formulated with plant and chemical mixtures as raw materials, so they are still irritating to the scalp.

[0005] Therefore, it is of great significance to develop mild anti-dandruff products to improve the scalp environment from the source to prevent dandruff and itching symptoms. Summary of the invention

[0006] In view of the above technical problems, the purpose of the present invention is to provide a pure plant anti-dandruff composition to solve the problem that the existing anti-dandruff shampoo products on the market are irritating to the scalp and destroying the scalp microenvironment. In order to achieve the above purpose, the technical solution adopted by the present invention is: a plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects, which includes the following raw materials by weight: 3-10 parts of emblica fruit extract, 1-8 parts of condiment Murraya extract, 0.03-0.25 parts of total sequence asparagus extract, 0.15-0.60 parts of hibiscus leaf extract and 0.15-0.60 parts of cymbidium extract.

[0007] Furthermore, the plant composition also includes a combination of one or more of neem extract, holy basil extract, night-blooming cereus extract, hibiscus flower extract or ginger root extract, preferably hibiscus flower extract; the weight portions are: 2-3 parts of neem extract, 0.01-0.15 parts of holy basil extract, 0.01-0.15 parts of night-blooming cereus extract, 0.2-2.5 parts of hibiscus flower extract and 3-5 parts of ginger root extract, preferably 0.2-2.5 parts of hibiscus flower extract.

[0008] In the technical solution adopted by the present invention,

[0009] Emblic fruit: Rich in tannins, phenols, flavonoids and other biologically active ingredients, amino acids, polysaccharides, vitamins and other substances, it has strong antioxidant, free radical scavenging and antibacterial activities; it can nourish hair, promote hair growth and make hair black and shiny.

[0010] Zhujin leaves: Contains dandelion acetate, β-sitosterol, amino acids, vitamins, hydroxy acids and other substances that are beneficial to the hair and scalp. They can promote hair growth, maintain scalp health, and reduce excessive oil secretion.

[0011] Tudinggui: It contains rich chemical components such as flavonoid glycosides, alkaloids, amino acids, etc. It can not only effectively inhibit Malassezia, but also has liver protection, anti-cancer, antioxidant and immune regulation effects.

[0012] Condiment Osmanthus fragrans: In folk culture, the spice Osmanthus fragrans has sedative and anti-inflammatory functions; it is rich in active substances such as carbazole alkaloids and polyphenols, and has biological activities such as antioxidant, free radical scavenging, antibacterial and anti-inflammatory.

[0013] General Introduction: Asparagus cochinchinensis: A famous tonic in Indian Ayurvedic medicine, its chemical components are mainly steroidal saponins, isoflavones, etc. It has biological activities such as lowering blood lipids, anti-ulcer, anti-stone, anti-radiation, and antibacterial, with fewer toxic and side effects.

[0014] Hibiscus tiliaceus: It mainly contains phenolic acids and flavonoid compounds, which have the effects of analgesia, anti-inflammatory, clearing heat and cooling blood, detoxification and dispersing nodules, and also have inhibitory effects on bacteria and fungi.

[0015] The research of the present invention shows that the compound of the six components achieves a synergistic effect, can effectively inhibit Malassezia and play an anti-dandruff and antipruritic effect, and at the same time has the effects of deep degreasing, oil control, anti-inflammatory and scalp barrier repair.

[0016] As a preferred embodiment of the plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects of the present invention, the weight ratio of the emblica fruit, hibiscus leaf, osmanthus fragrans, seasoning Murraya osmanthus, asparagus cochinchinensis and hibiscus flower is (3-10): (0.15-0.60): (0.15-0.60): (1-8): (0.03-0.25): (0.2-2.5).

[0017] The plant extracts of the present invention are compounded in the above-mentioned ratio, which can promote each other to achieve a better effect of inhibiting Malassezia and removing dandruff and relieving itching, while also having the effects of deep degreasing, oil control and anti-inflammatory repair.

[0018] As a preferred embodiment of the plant composition with anti-dandruff, antipruritic, anti-inflammatory and repairing effects of the present invention, the weight ratio of the emblica fruit, hibiscus leaf, osmanthus fragrans, spice Murraya odorata, asparagus cochinchinensis and hibiscus flower is emblica fruit: hibiscus leaf: osmanthus fragrans: spice Murraya odorata: asparagus cochinchinensis: hibiscus flower = (3-8): (0.15-0.25): (0.15-0.25): (1-6): (0.1-0.25): (0.25-0.5).

[0019] In particular, when the plant composition is compounded according to the above ratio, its antibacterial, anti-dandruff and antipruritic, anti-inflammatory and scalp barrier repairing effects are better.

[0020] As a preferred embodiment of the plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects of the present invention, the weight ratio of the emblica fruit, hibiscus leaf, osmanthus fragrans, spice Murraya odorata, asparagus cochinchinensis and hibiscus flower is 8:0.25:0.25:1:0.25:0.25.

[0021] After a series of experimental studies, it was found that when the plant composition is compounded according to the above ratio, its antibacterial, anti-dandruff and antipruritic, anti-inflammatory and repairing effects are optimal.

[0022] The second object of the present invention is to provide a use of the plant composition having the effects of anti-dandruff, anti-itching, anti-inflammatory and repairing in hair products. The use of any of the above-mentioned compositions in hair products also falls within the protection scope of the present invention.

[0023] The third object of the present invention is to provide a shampoo containing the plant composition with anti-dandruff, anti-itching, anti-inflammatory and repairing effects, wherein the weight percentage of the plant composition in the shampoo is 2-13%. As the content of the composition in the shampoo increases, the anti-dandruff effect also increases. When the addition amount of the composition is greater than 2%, the anti-dandruff effect is significant, and when the addition amount is greater than 13%, the anti-dandruff effect is not significant. Therefore, when the addition amount of the plant composition is 2%-13%, the anti-dandruff effect is significant.

[0024] As a preferred embodiment of the plant anti-dandruff shampoo of the present invention, the weight percentage of the plant composition in the shampoo is 10%.

[0025] As a preferred embodiment of the shampoo of the present invention, the shampoo also includes 5-40% anionic surfactant, 1-10% cocamidopropyl betaine, 0.05-3.0% cationic polymer, 0.05-3.0% pearlescent agent, 0.1-5.0% viscosity regulator, 0.01-0.30% chelating agent, 0.1-0.5% pH regulator, 0.1-0.2% preservative, 0.1-0.5% fragrance and the balance of deionized water.

[0026] Preferably, the anionic surfactant is at least one of alkyl sulfate ester salts, alkyl polyoxyethylene ether sulfate ester salts, sodium α-olefin sulfonate, disodium lauryl polyether sulfosuccinate, fatty acid monoglyceride sulfate, alkyl sulfonate, and N-acyl glycinate.

[0027] More preferably, the anionic surfactant is a combination of sodium α-olefin sulfonate and N-acyl glycinate in a weight ratio of (1:2) to (2:1).

[0028] The applicant found in the experiment that when N-acyl glycinate is used together with sodium α-olefin sulfonate, a good synergistic effect can be produced, such as significantly reducing the irritation of sodium α-olefin sulfonate, having excellent mildness, good washing performance, and good conditioning effect on hair. It was further found that when the weight ratio of the two is (1:2)-(2:1), the plant extract can be better stabilized, and the foam performance and mildness are also better.

[0029] Preferably, the cationic polymer is a cationic cellulose polymer or a cationic guar polymer.

[0030] Preferably, the viscosity regulator is one or a combination of sodium chloride, ammonium chloride, carbomer, xanthan gum, and acrylic copolymers.

[0031] Preferably, the pH adjuster is any one of citric acid, lactic acid, sodium citrate, or a combination of at least two of them.

[0032] Preferably, the chelating agent is disodium EDTA.

[0033] As a preferred embodiment of the shampoo of the present invention, the shampoo comprises the following components in weight percentage: 6% sodium α-olefin sulfonate, 12% sodium oleyl glycinate, 4% sodium cocoamphoacetate, 0.15% cationic guar gum, 10% plant composition, 1.5% ethylene glycol stearate, 0.15% disodium ethylenediaminetetraacetate, 0.1% preservative, 0.05% chelating agent, 0.4% fragrance, 0.15% pH regulator, 0.5% viscosity regulator and the balance of deionized water.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] The plant composition of the present invention is compounded by rationally selecting and scientifically proportioning the six ingredients of Phyllanthus emblica fruit, Hibiscus cinnamomi leaf, Cinnamomum tiliaceum, Murraya odorifera, Asparagus cochinchinensis and Hibiscus oleifera. Compared with a single component, the composition has better anti-dandruff, anti-itching and anti-inflammatory repairing effects, and will not damage the scalp microecological environment if used for a long time. It can be applied to a variety of hair care products, is safe, has few side effects, and has good application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 The effect of the plant composition at a 10% concentration on promoting the repair of the zebrafish embryo's tail fin

[0037] Figure 2 The effect of the plant composition on inhibiting the aggregation of neutrophils in zebrafish embryos at a concentration of 10% DETAILED DESCRIPTION

[0038] The present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation examples. The embodiments are only used to explain the present invention and are not intended to limit the scope of the present invention. The raw materials involved in the following embodiments are all commercially available general materials, and the test methods are all conventional methods.

[0039] As an embodiment of a plant composition with anti-dandruff, antipruritic, anti-inflammatory and repairing effects of the present invention, the plant composition includes the following components: emblica fruit, hibiscus leaf, osmanthus fragrans, seasoning Murraya osmanthus, asparagus root and hibiscus flower, the weight ratio of which is shown in Table 1, and the preparation method is the same.

[0040] The preparation method of the plant composition comprises the following steps: crushing the fruit of Phyllanthus emblica, the seasoning Murraya odoratus, the flower of hibiscus, the leaf of Hibiscus cinnamomi, the root of Asparagus cochinchinensis, and the root of ginger into coarse powder respectively, adding 10 times the amount of water / high-purity ethanol for soaking, heating and refluxing on a low fire for 2 times, each time for 1 hour, filtering, decolorizing, concentrating, and sterilizing after combining the filtrate, and finally fine filtering and collecting the filtrate to obtain the extracts of each plant. Finally, compounding is performed according to the weight ratio, and mixing is performed evenly to obtain the composition.

[0041] Examples I-X

[0042] Table 1

[0043]

[0044]

[0045] After a series of studies, it was found that according to Example 1 X When the weight ratios of the plants are used, the obtained plant composition achieves the best effects in terms of antibacterial and anti-oxidation.

[0046] The plant composition with the effects of removing dandruff, relieving itching, and resisting inflammation and repairing comprises the following components: emblica fruit, hibiscus leaf, osmanthus fragrans, spices Murraya odorifera, asparagus cochinchinensis and hibiscus flower, and the weight ratio of each of them is 8:0.25:0.25:1:0.25:0.25.

[0047] A suitable method for preparing the shampoo containing the plant anti-dandruff composition in Examples XI-XV is as follows: add an appropriate amount of water to a reaction tank, add guar gum under slow stirring to disperse, heat to 60°C to 80°C under slow stirring, and add an appropriate amount of citric acid to neutralize. Then add sodium oleyl glycine, disodium lauryl polyether sulfosuccinate, sodium α-olefin sulfonate, sodium lauryl polyoxyethylene ether sulfate, sodium coconut oil amphoteric acetate, decyl glucoside, ethylene glycol stearate, disodium ethylenediaminetetraacetate (if these substances are used), and keep these substances warm for 30 minutes after they are completely dispersed and dissolved, and start cooling. When the temperature drops to about 50°C, continue stirring the sodium chloride, citric acid, preservatives, pigments, flavors, etc. to obtain a shampoo base D, and finally mix the plant anti-dandruff composition with the base D and stir evenly. After all the components are added, a viscosity regulator and a pH regulator can be added as needed to adjust the viscosity and pH of the product to a suitable degree. Optionally, a small amount of water can be added at the end to make up.

[0048] Examples XI-XV

[0049] Table 2

[0050]

[0051]

[0052] Best Mode XIV

[0053] Table 3

[0054]

[0055] In Table 2-3: * is C 14－16Sodium olefin sulfonate; **The plant composition is a brown transparent liquid, composed of the following raw materials: emblica fruit: hibiscus leaf: osmanthus fragrans: seasoning Osmanthus fragrans: asparagus cochinchinensis: hibiscus flower = 8:0.25:0.25:1:0.25:0.25.

[0056] Performance Testing

[0057] 1. Security testing

[0058] 30 subjects were selected, and the plant composition samples prepared in Example IX were soaked with filter paper and placed in a patch tester. The control well was a blank sample (no substance was placed). The composition and the control sample were both attached to the curved side of the subject's forearm, and gently pressed with the palm of the hand to evenly apply it to the skin for 24 hours. After removing the patch device, wait for 30 minutes and observe the skin reaction after the indentation disappears. Observe again 24 hours and 48 hours after the patch test to determine the skin reaction. The test results are shown in Table 4

[0059] Table 4 Skin patch test results

[0060]

[0061] 2. Antibacterial property test: According to the QW66-Inhibition Zone Test Guide, the antibacterial property test was conducted on Examples I-X. If the diameter of the inhibition zone is greater than 5 (mm), it means that the antibacterial property is present. The larger the value, the better the antibacterial effect, which indicates the better antidandruff effect. The results are shown in Table 5.

[0062] Table 5

[0063]

[0064]

[0065] 3. Zebrafish efficacy test

[0066] The main mechanisms of dandruff include microbial colonization, sebum secretion, and scalp barrier damage. Microbial colonization and excessive secretion of oil can easily induce inflammatory reactions. The occurrence of dandruff is closely related to inflammation and scalp barrier damage. Therefore, zebrafish anti-inflammatory and repair efficacy tests can also be used as another form of expression.

[0067] (1) Anti-inflammatory efficacy test: Copper sulfate was used to induce damage to the neuromast cells in the lateral line region of zebrafish embryos to cause neutrophil aggregation. 24 fish embryos were exposed to 0.16 mg / L copper sulfate pentahydrate and 5 sample solutions of plant composition concentrations set from low to high (diluted to the desired concentration with fish embryo culture medium). A model control group was also set up. After 40 minutes of exposure, the fish embryos were fixed and stained with Sudan black, and the number of neutrophils in the lateral line region was counted and statistically analyzed. The test results are shown in Table 6. Pictures of inhibition of neutrophil aggregation are shown in the attached Figure 1 .

[0068] Among them, the plant composition used for testing is composed of the following raw materials: emblica fruit: hibiscus leaf: osmanthus fragrans: seasoning Murraya osmanthus: asparagus cochinchinensis: hibiscus flower = 8: 0.25: 0.25: 1: 0.25: 0.25.

[0069] Table 6

[0070]

[0071] Conclusion: The plant composition can significantly inhibit the aggregation of neutrophils in zebrafish embryos and has anti-inflammatory and soothing effects.

[0072] (2) Repair efficacy test: The test was conducted using a zebrafish embryo tail fin removal model. 24 tail fin removed fish embryos were exposed to 5 sample solutions of plant composition concentrations (from low to high) (diluted to the desired concentration using fish embryo culture medium), and a model control group was set up. After 48 hours of exposure, the fish embryos were photographed under a microscope, and the length of the tail fin regeneration was measured and statistically analyzed. The test results are shown in Table 7. The picture of the tail fin of the repaired zebrafish embryo is attached. Figure 2 .

[0073] Among them, the plant composition used for testing is composed of the following raw materials: emblica fruit: hibiscus leaf: osmanthus fragrans: seasoning Murraya osmanthus: asparagus cochinchinensis: hibiscus flower = 8: 0.25: 0.25: 1: 0.25: 0.25.

[0074] Table 7

[0075]

[0076] Conclusion: The plant composition can significantly promote the regeneration of zebrafish embryonic tail fin and has a repairing effect.

[0077] 4. Volunteer experience test

[0078] Test method: 96 volunteers with moderate dandruff and dry scalp and hair were selected, and they were required to have no seborrheic dermatitis, no allergies, and no wounds. Before the trial, the volunteers were evaluated for sensory and hair images. Sample 1 and Sample 2 (48 copies each) were randomly distributed without revealing the information of the trial products to the volunteers and evaluators. The volunteers were asked to use them continuously (using the samples according to the daily frequency of use). After the 14th day (two weeks), the use was stopped. The dandruff and itchy scalp were observed and scored at the 12th hour, 24th hour and 48th hour after the cessation of use. The evaluators analyzed and then unblinded (Sample 1 is the best embodiment XIV shampoo of the present invention; Sample 2 is a blank control shampoo without adding the plant composition). The comprehensive evaluation is shown in Table 8.

[0079] The volunteers' skin scores before and after use are 1, 2, 3, 4, 5 points. The higher the score, the better the effect. 1-2: ineffective; 2-3: moderate; 3-4: good; 4-5: very good. Sensory evaluation of the volunteers' hair before and after using the product.

[0080] Table 8

[0081]

[0082]

[0083] From the statistics of dandruff reduction and itch reduction in Table 8, the ineffective percentage of the best embodiment of the present invention is significantly lower than that of the blank control embodiment of the present invention.

[0084] 5. Efficacy verification

[0085] 60 volunteers with dandruff problems were recruited and randomly divided into three groups, each with 20 people. Each group used different products, including one shampoo according to the best embodiment XIV of the present invention and two commercially available shampoo products, one of which was commercially available A and the other was commercially available B.

[0086] Without disclosing the information of the products to be tried to the volunteers and the evaluators, the first group used the commercially available shampoo product A (containing only chemical antidandruff agents), the second group used the shampoo of the best embodiment XIV of the present invention, and the third group used the commercially available shampoo product B (containing chemical antidandruff agents and plant antidandruff agents). They continued to use (at a frequency of 3 times per week), stopped using it on the 14th day (after two weeks), filled in the trial form for scoring, and comprehensively evaluated their use experience and effects. The results are shown in Table 9.

[0087] Among them, 1-2: ineffective / very irritating; 2-3: moderate / irritating; 3-4: good / somewhat irritating; 4-5: very good / no irritation.

[0088] Table 9

[0089]

[0090] As can be seen from Table 9, the shampoo of the best embodiment XIV of the present invention has the same anti-dandruff effect as the commercially available products, but is milder. It is worth mentioning that most of the volunteers in the first group (using the commercially available product A-chemical anti-dandruff) reported that the degreasing power was too strong after washing, and the scalp and hair felt dry and astringent, while a few volunteers in the third group (using the commercially available product B-chemical + plant anti-dandruff) reported that the scalp and hair felt dry and astringent after washing, and were not moisturized enough, indicating that using a shampoo containing only plant anti-dandruff agents is safer and milder than a shampoo containing chemical anti-dandruff agents.

Claims

1. A plant composition with anti-dandruff, antipruritic, anti-inflammatory and repairing effects, characterized in that: The invention comprises, by weight, 8 parts of emblica fruit extract, 1 part of spice Murraya odorifera extract, 0.25 parts of asparagus cochinchinensis extract, 0.25 parts of hibiscus calamus leaf extract, 0.25 parts of osmanthus fragrans extract and 0.25 parts of hibiscus calamus flower extract.

2. A use of the plant composition according to claim 1, characterized in that: Used in the preparation of hair products.

3. The use of the plant composition according to claim 2, characterized in that: Used in preparing shampoo.

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