A temperature feedback photoelectric dual response thermosensitive patch and method based on MXene

Abstract

The present invention belongs to the field of thermal therapy technology, and specifically relates to a temperature feedback photoelectric dual-response thermosensitive patch and method based on MXene. Among them, a temperature feedback photoelectric dual-response thermosensitive patch based on MXene includes, from bottom to top: a base layer; a bacterial cellulose layer; a photoelectric response layer, which has a MXene ring antenna; and an encapsulation layer. The photoelectric response layer of the present invention is a core component with excellent electrical conductivity and thermal conductivity. It can efficiently convert external input infrared light, direct current and other excitations into thermal energy. The MXene ring antenna can be quickly heated up by inputting infrared light signals at an appropriate distance or a direct current voltage within the safety range of the human body, thereby achieving efficient and precise skin heating and completing controllable local thermal therapy. The temperature can be adjusted in a large range to meet different heating needs.

Description

Technical Field

[0001] The present invention belongs to the field of thermal therapy technology, and specifically relates to a temperature feedback photoelectric dual-response thermosensitive patch and method based on MXene. Background Art

[0002] Radio frequency antennas have extremely wide applications in the current rapid development of portable and wearable devices. Compared with traditional metal antennas, flexible printed antennas are more in line with the development needs of portable and wearable devices. The emerging two-dimensional material family of transition metal carbides and nitride nanomaterials (MXenes) has extremely superior electrical conductivity. The electrical conductivity of MXene sheets is as high as 5000-10000S / cm, which enables MXene antennas to achieve the same antenna efficiency as traditional metal antennas with a thinner thickness. MXene sheets with high surface chemical activity have good hydrophilic properties. Therefore, the MXene aqueous solution without any additives is a colloidal dispersion with excellent uniformity, which is suitable as an ink for antenna processing on flexible substrates using methods such as spraying, spin coating, drip coating and screen printing.

[0003] MXene materials have high carrier mobility and high thermal conductivity. Under the action of an external electric field, they can generate a large number of effective carrier thermal motion collisions, thus achieving significant Joule heating even under low-voltage drive. Furthermore, MXene materials with certain surface chemical functional groups possess rich and tunable band structures. Commonly used titanium carbide MXene materials have broad absorption in the visible-infrared spectral region, especially with excellent photothermal conversion efficiency for infrared light, and have been used to construct various novel photothermal therapeutic agents. Furthermore, the excellent mechanical strength and thermal stability of MXene materials enable their integration with various flexible processing technologies, showing great potential in the construction of flexible, wearable heating devices.

[0004] It is worth noting that existing thermosensitive materials and local thermal therapy technologies usually heat through the principles of electric current thermal effect or photothermal effect. The heating efficiency is low, the heating method lacks flexibility, and there is a lack of certain real-time skin temperature detection and feedback capabilities. Prolonged excessive heating temperature can cause low-temperature burns on skin tissue. Summary of the Invention

[0005] The present invention addresses the technical problems of slow thermal response and uncontrollable heating in existing thermal therapy devices, and aims to provide a MXene-based temperature feedback photoelectric dual-response thermosensitive patch and method.

[0006] A MXene-based temperature feedback photoelectric dual-response thermosensitive patch, comprising from bottom to top:

[0007] a basal layer;

[0008] a bacterial cellulose layer;

[0009] a photoelectric response layer having a MXene ring antenna;

[0010] An encapsulation layer.

[0011] As a preferred solution, the base layer is made of medical double-sided tape.

[0012] As a preferred embodiment, the bacterial cellulose layer is modified by the following method:

[0013] Cutting the bacterial cellulose hydrogel into desired shapes and drying it in an oven;

[0014] sticking the dried bacterial cellulose hydrogel to the sticky surface of the base layer;

[0015] After the screen printing of the photoelectric response layer is completed, the bacterial cellulose hydrogel is converted into the bacterial cellulose layer through hot pressing, and is respectively connected to the base layer and the photoelectric response layer.

[0016] As a preferred solution, the photoelectric response layer further comprises:

[0017] a near-field communication chip, located inside the inner circle of the MXene loop antenna, connected to the inner circle end of the MXene loop antenna, and connected to the outer circle end of the MXene loop antenna via the MXene antenna outer circle introduction and output end, wherein the MXene antenna outer circle introduction and output end are insulated from the MXene loop antenna by a bacterial cellulose insulation strip;

[0018] A microcontroller unit is located inside the inner circle of the MXene ring antenna and is connected to the near-field communication chip via a MXene wire.

[0019] As a preferred solution, the MXene ring antenna, the MXene antenna outer ring introduction output end and the MXene wire are all obtained by screen printing MXene ink through several layers, preferably 5 layers of screen printing.

[0020] As a preferred embodiment, the MXene ink is obtained by the following method:

[0021] The ceramic phase titanium aluminum carbon powder is chemically etched using hydrochloric acid and lithium fluoride, the mixed solution is centrifuged and the supernatant is removed, deionized water is added to soak the obtained precipitate, and the precipitate is dispersed by shaking;

[0022] Repeat centrifugation and vortexing with deionized water to precipitate until the precipitate cannot be redispersed;

[0023] The bottom precipitate was broken up, redispersed, and sonicated;

[0024] After centrifugation and removal of the supernatant, the viscous black ink-like precipitate was collected to obtain the additive-free MXene ink.

[0025] As a preferred solution, the screen printing process of the photoelectric response layer is:

[0026] Printing several layers of the MXene ink on the substrate layer with the bacterial cellulose hydrogel to prepare the MXene loop antenna;

[0027] After the printed MXene loop antenna is dried at room temperature, a bacterial cellulose hydrogel is placed to provide insulation, and then several layers of the MXene ink are printed on this basis to obtain the MXene antenna outer ring lead-in output terminal and the MXene wire. The MXene ink is also dried at room temperature.

[0028] Performing heat pressing treatment enables the bacterial cellulose hydrogel to be connected to the base layer and the photoelectric response layer respectively.

[0029] As a preferred solution, the micro control unit is a microprocessor chip with a built-in temperature sensor.

[0030] As a preferred solution, the encapsulation layer is a polydimethylsiloxane encapsulation layer made of polydimethylsiloxane (PDMS) solution.

[0031] As a preferred embodiment, the polydimethylsiloxane encapsulation layer is obtained by the following method:

[0032] The assembled base layer, bacterial cellulose layer and photoelectric response layer are placed in a 3D printing resin mold, polydimethylsiloxane (PDMS) solution is poured, the thickness of the polydimethylsiloxane film is controlled by volume, and demolding is performed after heat treatment and curing.

[0033] A method for preparing a temperature feedback photoelectric dual-response thermosensitive patch based on MXene, comprising:

[0034] Cutting the bacterial cellulose hydrogel into a desired shape and drying it in an oven, and pasting the dried bacterial cellulose hydrogel on the sticky surface of the substrate;

[0035] Several layers of MXene ink are printed on a substrate layer with bacterial cellulose hydrogel to prepare a MXene loop antenna. After the printed MXene loop antenna is dried at room temperature, bacterial cellulose hydrogel is placed on it, and several layers of MXene ink are printed on this basis to obtain the outer ring of the MXene antenna and the MXene wire. The MXene ink is also dried at room temperature and then subjected to hot pressing.

[0036] Solder the near field communication chip and micro control unit separately;

[0037] The assembled base layer, bacterial cellulose layer and photoelectric response layer are placed in a 3D printing resin mold, polydimethylsiloxane solution is poured, and the mold is removed after heat treatment and curing to obtain a thermosensitive patch.

[0038] A MXene-based temperature feedback photoelectric dual-response thermosensitive patch physiotherapy method, comprising:

[0039] The thermosensitive patch of the present invention is pasted on the skin surface, and the photoelectric response layer is excited by infrared light or direct current to achieve heating. The heating temperature of the thermosensitive patch is controlled by adjusting the infrared light irradiation distance or voltage.

[0040] As a preferred solution, it also includes:

[0041] The skin surface temperature is collected using the temperature sensor built into the microcontroller unit in the photoelectric response layer, and the temperature information is sent to the mobile terminal device via wireless transmission through the near-field communication chip and MXene ring antenna in the photoelectric response layer, thereby achieving real-time temperature feedback.

[0042] The positive progress of the present invention is that the present invention adopts a temperature feedback photoelectric dual response thermosensitive patch and method based on MXene, which has the following advantages:

[0043] 1. The base layer serves as a skin adhesion layer and can be easily adhered to the skin surface. It can fit perfectly and tightly to any skin position according to the user's needs, and is extremely comfortable.

[0044] 2. The bacterial cellulose layer acts as a hydrophilic modification to improve the printing stability and graphic accuracy of the photoelectric response layer through a hydrogen bond network, thereby enhancing the interlayer connection strength of the thermosensitive patch.

[0045] 3. As the core component, the photoelectric response layer has excellent electrical conductivity and thermal conductivity, and can efficiently convert external input infrared light, direct current and other stimuli into thermal energy. Through the input of infrared light signals at an appropriate distance or DC voltage within the human body's safety range, the MXene ring antenna can quickly heat up, achieving high-efficiency and precise skin heating, completing controllable local thermal therapy, and the temperature can be adjusted in a large range to meet different heating needs.

[0046] 4. The resonant frequency of the MXene loop antenna is preferably designed to be 13.56 MHz, which not only meets the protocol requirements of near-field communication, but also gives the antenna good Joule heat generation efficiency.

[0047] 5. Through the design of near-field communication chips and microcontrollers, wireless communication between the thermal patch and mobile terminal devices such as mobile phones can be achieved. In particular, combined with the temperature sensor built into the microcontroller chip, the temperature, an important parameter of the heating process, can be visualized and controllable, making the operation simple and achieving real-time temperature data feedback. This effectively reduces the risk of low-temperature burns in skin thermal stimulation therapy, meeting the development needs of smart wearable devices.

[0048] 6. The encapsulation layer can prevent sweat contamination, especially the use of polydimethylsiloxane to encapsulate the photoelectric response layer, which can not only slow down the degradation of MXene in the air, but also eliminate the interference of sweat and other substances during the heating process, greatly extending the service life of the thermosensitive patch.

[0049] 7. The present invention is applicable to daily health physiotherapy management. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 A hierarchical structure diagram of a thermal patch provided by an embodiment of the present invention;

[0051] Figure 2 A top view of a thermal patch provided in an embodiment of the present invention;

[0052] Figure 3 A graph showing the relationship between the resistance of the MXene loop antenna and the number of screen printing cycles provided by an embodiment of the present invention;

[0053] Figure 4 A graph showing the relationship between the temperature of the thermal patch and the infrared irradiation distance provided by an embodiment of the present invention;

[0054] Figure 5 A diagram showing the relationship between the temperature and DC voltage of the thermistor patch provided in an embodiment of the present invention;

[0055] Figure 6 This is a temperature response diagram of the thermistor patch under 6V DC voltage input provided by an embodiment of the present invention. DETAILED DESCRIPTION

[0056] In order to make the technical means, creative features, objectives and effects achieved by the present invention easier to understand, the present invention is further described below with reference to specific illustrations.

[0057] Reference Figure 1 and Figure 2 An embodiment of the present invention provides a temperature feedback photoelectric dual-response thermosensitive patch based on MXene, comprising, from bottom to top, a base layer 1, a bacterial cellulose layer 2, a photoelectric response layer 3 and an encapsulation layer 4.

[0058] In this embodiment, the base layer 1 is made of a medical double-sided tape, which serves as a skin adhesive layer and also as a base of the thermosensitive patch.

[0059] In this embodiment, the medical double-sided tape is preferably 3M 1513 transparent polyester double-sided medical tape, which is cut into a suitable size and used as the base layer 1 of the thermal patch. After the base material is torn off, it can be firmly attached to the skin.

[0060] In this embodiment, the bacterial cellulose layer 2 is modified by the following method:

[0061] The bacterial cellulose hydrogel is cut into the desired shape and dried in an oven; the dried bacterial cellulose hydrogel is pasted on the sticky surface of the base layer 1; after the screen printing of the photoelectric response layer 3 is completed, the bacterial cellulose hydrogel is converted into the bacterial cellulose layer 2 by heat pressing, and the bacterial cellulose layer 2 is connected to the base layer 1 and the photoelectric response layer 3 respectively.

[0062] In this embodiment, the bacterial cellulose layer 2 is modified by the following method:

[0063] The bacterial cellulose hydrogel is first immersed in a sodium hydroxide solution at 80 degrees Celsius and with a mass concentration of 2%, and then washed with deionized water to obtain a clean bacterial cellulose hydrogel; the clean bacterial cellulose hydrogel is cut into the desired shape and dried in an oven until its moisture content reaches 30%; the dried bacterial cellulose hydrogel is pasted on the sticky surface of the medical double-sided tape without a substrate; after completing the screen printing of the photoelectric response layer 3 (MXene ring antenna 31, MXene antenna outer ring introduction output end 33 and MXene wire 35), the bacterial cellulose hydrogel is converted into a bacterial cellulose layer 2 by a hot pressing treatment at 15 MPa, 90 degrees Celsius and 30 minutes, and connected to the medical double-sided tape and the photoelectric response layer 3.

[0064] In this embodiment, referring to Figure 2 The photoelectric response layer 3 includes a MXene loop antenna 31, a bacterial cellulose insulating strip 32, a MXene antenna outer ring lead-in output terminal 33, a near-field communication chip 34, a MXene wire 35, and a microcontroller unit 36. The near-field communication chip 34 and the microcontroller unit 36 ​​are both located inside the inner ring of the MXene loop antenna 31. The inner ring end of the MXene loop antenna 31 is directly connected to the near-field communication chip 34, while the outer ring end of the MXene loop antenna 31 is connected to the near-field communication chip 34 via the MXene antenna outer ring lead-in output terminal 33. The MXene antenna outer ring lead-in output terminal 33 is insulated from the MXene loop antenna 31 by the bacterial cellulose insulating strip 32. The microcontroller unit 36 ​​is connected to the near-field communication chip 34 via the MXene wire 35.

[0065] The MXene loop antenna 31 has excellent light response capability, such as Figure 4As shown in the figure, the relationship between the temperature of the thermosensitive patch and the infrared irradiation distance is shown. At an irradiation distance of 5.5 cm, a heating temperature of 50.1°C can be obtained, which is suitable for thermal stimulation of human skin. Figure 5 As shown in the figure, the relationship between the temperature of the thermistor patch and the DC voltage is shown, which verifies the outstanding electrical response heating capability of the MXene loop antenna 31. The operating voltage is completely within the range of human safety, and a DC voltage input of 7V can reach 49.2 degrees Celsius. Figure 6 The figure below shows the temperature response curve of the thermistor patch under a 6V DC voltage input. The temperature rises to its maximum temperature in approximately 40 seconds. After the input voltage is removed, the temperature drops very quickly. This demonstrates the high efficiency of the photoelectric thermal response and its suitability for thermal stimulation in physical therapy.

[0066] In this embodiment, the MXene loop antenna 31, the MXene antenna outer ring lead-in output terminal 33 and the MXene wire 35 are all obtained by screen printing MXene ink through several layers, preferably 5 layers.

[0067] The resistance of the MXene loop antenna 31 can be adjusted by the number of screen printing times. Figure 3 As shown, the relationship between the resistance of the MXene loop antenna 31 and the number of printing times is demonstrated. When the number of printing times is 5, the resistance of the MXene loop antenna 31 is significantly reduced to 84.1Ω, which not only makes the resonant frequency of the MXene loop antenna 31 13.56MHz, which meets the requirements of the near-field communication protocol, but also gives the antenna good Joule heat generation efficiency.

[0068] In this embodiment, MXene ink is prepared by etching the ceramic phase titanium aluminum carbon with a hydrochloric acid / lithium fluoride solution. The preparation process is as follows:

[0069] The ceramic phase titanium aluminum carbon powder was chemically etched using hydrochloric acid and lithium fluoride. The mixture was centrifuged and the supernatant was removed. Deionized water was added to soak the resulting precipitate and the precipitate was dispersed by oscillation. The centrifugation and deionized water vortex oscillation precipitation were repeated until the precipitate could not be redispersed. The bottom precipitate was broken up, redispersed, and ultrasonicated. After centrifugation and removal of the supernatant, the viscous black ink-like precipitate was collected to obtain an additive-free MXene ink.

[0070] In this embodiment, the specific preparation process of MXene ink is as follows:

[0071] 2.25 parts by mass of lithium fluoride were dissolved in 45 parts by volume of concentrated hydrochloric acid, and then 2 parts by mass of 400-mesh ceramic phase titanium aluminum carbon powder were added and etched at 45°C for 24 hours; the mixture was centrifuged at 5000 rpm for 10 minutes, the supernatant was removed, deionized water was added to soak the resulting precipitate, and a vortex generator with an oscillation power of 9 watts was used to re-oscillate and disperse the precipitate for 10 minutes. The above centrifugal washing steps were repeated until the precipitate could not be re-dispersed using a vortex oscillator; the bottom precipitate was crushed, re-dispersed, and ultrasonicated for 30 minutes; centrifuged at 10000 rpm for 10 minutes, and after removing the supernatant, a significantly expanded and stratified black ink-like precipitate was obtained. This part is the additive-free MXene ink composed of a single layer of MXene, which can be used for screen printing.

[0072] In this embodiment, the screen printing process of the photoelectric response layer 3 is as follows:

[0073] Several layers of MXene ink are printed on the base layer 1 with bacterial cellulose hydrogel to prepare a MXene loop antenna 31; after the printed MXene loop antenna 31 is dried at room temperature, bacterial cellulose hydrogel is placed to play an insulating role (subsequent hot pressing treatment results in a bacterial cellulose insulating strip 32), and then several layers of MXene ink are printed on this basis to obtain the MXene antenna outer ring introduction output terminal 33 and the MXene wire 35, and the MXene ink is also dried at room temperature; hot pressing treatment is performed to enable the bacterial cellulose hydrogel to be connected to the base layer 1 and the photoelectric response layer 3 respectively.

[0074] In this embodiment, the specific process of screen printing the photoelectric response layer 3 is as follows:

[0075] A screen printer and a 300-mesh steel mesh were used to print five layers of MXene ink on a medical double-sided tape adhered with bacterial cellulose hydrogel to prepare a MXene loop antenna 31. After the printed MXene loop antenna 31 was dried at room temperature, a small-sized bacterial cellulose hydrogel was placed to perform an insulating function. On this basis, a screen printer and a 300-mesh steel mesh were used to complete the printing of five layers of MXene ink to obtain the MXene antenna outer ring introduction output terminal 33 and the MXene wire 35. The MXene ink was also dried at room temperature. A hot pressing treatment was performed at 15 MPa and 90 degrees Celsius for 30 minutes to convert the bacterial cellulose hydrogel into the bacterial cellulose layer 2, thereby enhancing the overall bonding strength of the thermosensitive patch.

[0076] In this embodiment, the microcontroller unit 36 ​​is a microprocessor chip with a built-in temperature sensor. This allows the present invention to use the built-in temperature sensor in the microprocessor chip to collect skin surface temperature and wirelessly transmit the data to a mobile terminal device via the MXene loop antenna 31 and near-field communication chip 34, achieving real-time temperature feedback.

[0077] In this embodiment, the near field communication chip 34 is preferably NT3H2111, and is soldered to the photoelectric response layer 3 using low-temperature solder.

[0078] In this embodiment, the micro control unit 36 ​​is preferably MSP430FR2632, and is soldered to the photoelectric response layer 3 using low-temperature solder.

[0079] In this embodiment, the encapsulation layer 4 is a polydimethylsiloxane encapsulation layer 4 made of a polydimethylsiloxane (PDMS) solution.

[0080] In this embodiment, the polydimethylsiloxane encapsulation layer 4 is obtained by the following method:

[0081] The assembled base layer 1, bacterial cellulose layer 2 and photoelectric response layer 3 are placed in a 3D printing resin mold, and polydimethylsiloxane (PDMS) solution is poured. The thickness of the polydimethylsiloxane film is controlled by volume, and the mold is removed after heat treatment and curing.

[0082] In this embodiment, the thickness of the polydimethylsiloxane film is controlled to be 1 mm by volume.

[0083] The embodiment of the present invention provides a method for manufacturing a temperature feedback photoelectric dual-response thermosensitive patch based on MXene, comprising:

[0084] S1, cutting the bacterial cellulose hydrogel into a desired shape and drying it in an oven; and pasting the dried bacterial cellulose hydrogel on the sticky surface of the base layer 1.

[0085] Specifically, the bacterial cellulose hydrogel is first immersed in a sodium hydroxide solution at 80 degrees Celsius and with a mass concentration of 2%, and then washed with deionized water to obtain a clean bacterial cellulose hydrogel; the clean bacterial cellulose hydrogel is cut into a desired shape and dried in an oven until its moisture content reaches 30%; and the dried bacterial cellulose hydrogel is adhered to the sticky side of a medical double-sided tape without a substrate.

[0086] S2, printing several layers of MXene ink on the base layer 1 with bacterial cellulose hydrogel to prepare a MXene loop antenna 31; after the printed MXene loop antenna 31 is dried at room temperature, a bacterial cellulose hydrogel that plays an insulating role is placed (a bacterial cellulose insulating strip 32 is obtained after subsequent hot pressing treatment), and then completing several layers of MXene ink printing on this basis to obtain the MXene antenna outer ring introduction output terminal 33 and the MXene wire 35, and similarly allowing the MXene ink to dry at room temperature; performing hot pressing treatment so that the bacterial cellulose hydrogel can be connected to the base layer 1 and the photoelectric response layer 3 respectively.

[0087] Specifically, a screen printer and a 300-mesh steel mesh were used to print five layers of MXene ink on a medical double-sided tape adhered with bacterial cellulose hydrogel to prepare a MXene loop antenna 31. After the printed MXene loop antenna 31 was dried at room temperature, a small-sized bacterial cellulose hydrogel was placed to perform an insulating function. On this basis, a screen printer and a 300-mesh steel mesh were used to complete the five-layer printing of MXene ink to obtain the MXene antenna outer ring introduction output terminal 33 and the MXene wire 35. The MXene ink was also dried at room temperature. A hot pressing treatment was performed at 15 MPa and 90 degrees Celsius for 30 minutes to convert the bacterial cellulose hydrogel into the bacterial cellulose layer 2, thereby enhancing the overall bonding strength of the thermosensitive patch.

[0088] MXene ink is prepared by etching the ceramic phase titanium aluminum carbon with hydrochloric acid / lithium fluoride solution. The preparation process is as follows:

[0089] The ceramic phase titanium aluminum carbon powder was chemically etched using hydrochloric acid and lithium fluoride. The mixture was centrifuged and the supernatant was removed. Deionized water was added to soak the resulting precipitate and the precipitate was dispersed by oscillation. The centrifugation and deionized water vortex oscillation precipitation were repeated until the precipitate could not be redispersed. The bottom precipitate was broken up, redispersed, and ultrasonicated. After centrifugation and removal of the supernatant, the viscous black ink-like precipitate was collected to obtain an additive-free MXene ink.

[0090] Specifically, 2.25 parts by mass of lithium fluoride were dissolved in 45 parts by volume of concentrated hydrochloric acid, and then 2 parts by mass of 400-mesh ceramic phase titanium aluminum carbon powder were added, and the mixture was etched at 45°C for 24 hours; the mixture was centrifuged at 5000 rpm for 10 minutes, the supernatant was removed, deionized water was added to soak the resulting precipitate, and a vortex generator with an oscillation power of 9 watts was used to re-oscillate and disperse the precipitate for 10 minutes, and the above centrifugation and washing steps were repeated until the precipitate could not be re-dispersed using a vortex oscillator; the bottom precipitate was crushed, re-dispersed, and ultrasonicated for 30 minutes; centrifuged at 10,000 rpm for 10 minutes, and after removing the supernatant, a significantly expanded and stratified black ink-like precipitate was obtained. This part is the additive-free MXene ink composed of a single layer of MXene, which can be used for screen printing.

[0091] S3 , the near field communication chip 34 and the micro control unit 36 ​​are respectively welded in the photoelectric response layer 3 , completing the assembly of the photoelectric response layer 3 .

[0092] Specifically, the near field communication chip 34 and the micro control unit 36 ​​are respectively soldered to the photoelectric response layer 3 using low-temperature solder.

[0093] S4, placing the assembled base layer 1, bacterial cellulose layer 2 and photoelectric response layer 3 in a 3D printing resin mold, pouring polydimethylsiloxane (PDMS) solution, controlling the thickness of the polydimethylsiloxane film by volume, and demolding after heat treatment and curing to obtain the thermosensitive patch of the present invention.

[0094] The embodiment of the present invention provides a MXene-based temperature feedback photoelectric dual-response thermosensitive patch physical therapy method, comprising:

[0095] The thermosensitive patch of the present invention is pasted on the skin surface, and the photoelectric response layer 3 is excited by infrared light or direct current to achieve heating. The heating temperature of the thermosensitive patch can be controlled by adjusting the infrared light irradiation distance or voltage.

[0096] In this embodiment, the physical therapy method further includes:

[0097] The skin surface temperature is collected using the temperature sensor built into the microcontroller unit 36 ​​in the photoelectric response layer 3, and the temperature information is sent to the mobile terminal device via wireless transmission through the near-field communication chip 34 and the MXene ring antenna 31 in the photoelectric response layer 3, thereby achieving real-time temperature feedback.

[0098] The basic principles, main features, and advantages of the present invention are shown and described above. Those skilled in the art should understand that the present invention is not limited to the foregoing embodiments. The foregoing embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A temperature feedback photoelectric dual response thermosensitive patch based on MXene, characterized in that: From bottom to top: a basal layer; a bacterial cellulose layer; a photoelectric response layer having a MXene ring antenna; an encapsulation layer; The photoelectric response layer further comprises: a near-field communication chip, located inside the inner circle of the MXene loop antenna, connected to the inner circle end of the MXene loop antenna, and connected to the outer circle end of the MXene loop antenna via the MXene antenna outer circle introduction and output end, wherein the MXene antenna outer circle introduction and output end are insulated from the MXene loop antenna by a bacterial cellulose insulation strip; A microcontroller unit is located inside the inner circle of the MXene ring antenna and is connected to the near-field communication chip via a MXene wire. The microcontroller unit is a microprocessor chip with a built-in temperature sensor.

2. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 1, characterized in that: The base layer is a medical double-sided tape.

3. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 1, characterized in that: The bacterial cellulose layer is modified by the following method: Cutting the bacterial cellulose hydrogel into desired shapes and drying it in an oven; sticking the dried bacterial cellulose hydrogel to the sticky surface of the base layer; After the screen printing of the photoelectric response layer is completed, the bacterial cellulose hydrogel is converted into the bacterial cellulose layer through hot pressing, and is respectively connected to the base layer and the photoelectric response layer.

4. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 1, characterized in that: The MXene ring antenna, the MXene antenna outer ring introduction output end and the MXene wire are all obtained by screen printing several layers of MXene ink.

5. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 4, characterized in that: The MXene ring antenna, the MXene antenna outer ring introduction output end and the MXene wire are all obtained by 5-layer screen printing of MXene ink.

6. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 4, characterized in that: The MXene ink is obtained by the following method: The ceramic phase titanium aluminum carbon powder is chemically etched using hydrochloric acid and lithium fluoride, the mixed solution is centrifuged and the supernatant is removed, deionized water is added to soak the obtained precipitate, and the precipitate is dispersed by shaking; Repeat centrifugation and vortexing with deionized water to precipitate until the precipitate cannot be redispersed; The bottom precipitate was broken up, redispersed, and sonicated; After centrifugation and removal of the supernatant, the viscous black ink-like precipitate was collected to obtain the additive-free MXene ink.

7. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 6, characterized in that: The screen printing process of the photoelectric response layer is as follows: Printing several layers of the MXene ink on the substrate layer with the bacterial cellulose hydrogel to prepare the MXene loop antenna; After the printed MXene loop antenna is dried at room temperature, a bacterial cellulose hydrogel is placed to provide insulation, and then several layers of the MXene ink are printed on this basis to obtain the MXene antenna outer ring lead-in output terminal and the MXene wire. The MXene ink is also dried at room temperature. Performing heat pressing treatment enables the bacterial cellulose hydrogel to be connected to the base layer and the photoelectric response layer respectively.

8. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 1, characterized in that: The encapsulation layer is a polydimethylsiloxane encapsulation layer made of polydimethylsiloxane solution.

9. The MXene-based temperature feedback photoelectric dual-response thermosensitive patch according to claim 8, characterized in that: The polydimethylsiloxane encapsulation layer is obtained by the following method: The assembled base layer, bacterial cellulose layer and photoelectric response layer are placed in a 3D printing resin mold, polydimethylsiloxane solution is poured, the thickness of the polydimethylsiloxane film is controlled by volume, and the mold is removed after heat treatment and curing.

10. A method for preparing a temperature feedback photoelectric dual-response thermosensitive patch based on MXene, characterized in that: include: Cutting the bacterial cellulose hydrogel into a desired shape and drying it in an oven, and pasting the dried bacterial cellulose hydrogel on the sticky surface of the substrate; Several layers of MXene ink are printed on a substrate layer with bacterial cellulose hydrogel to prepare a MXene loop antenna. After the printed MXene loop antenna is dried at room temperature, bacterial cellulose hydrogel is placed on it, and several layers of MXene ink are printed on this basis to obtain the outer ring of the MXene antenna and the MXene wire. The MXene ink is also dried at room temperature and then subjected to hot pressing. Solder the near field communication chip and micro control unit separately; The assembled base layer, bacterial cellulose layer and photoelectric response layer are placed in a 3D printing resin mold, polydimethylsiloxane solution is poured, and the mold is removed after heat treatment and curing to obtain a thermosensitive patch.

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