Water-soluble personal lubricant and its preparation method

Abstract

This application relates to the technical field of lubricating products, and specifically discloses a water-soluble personal lubricant and a preparation method thereof. The personal lubricant is formed by mixing Agent A and Agent B. Agent A includes the following components by weight percentage: 30-47% glycerol, 2-4% Tween-20, 0.05-0.15% sodium hyaluronate, 0.1-0.3% jasmine essential oil, 0.5-1.2% aloe essential oil, 0.5-0.8% preservative, and the balance is made up to 100% with water; the components of Agent B include cyclodextrin. In this application, the hydrophobic region in the center of the cyclodextrin molecule accommodates and adsorbs the hydrophobic end of Tween-20, and more hydrophilic groups are introduced around the molecule of Tween-20, reducing the influence of Tween-20 on the lubricating performance and improving the lubricating performance of the personal lubricant.

Description

Technical Field

[0001] This application relates to the technical field of lubricating products. More specifically, it relates to a water-soluble personal lubricant and a preparation method thereof. Background Art

[0002] Personal lubricants are lubricants specially designed for the human body, mainly used for vaginal lubrication, applicable to vaginal dryness caused by endocrine changes, menopause, gynecological surgery or mental factors, etc., and can also be used as a lubricant for smearing on the surface of medical devices during gynecological examinations. While having a lubricating effect, personal lubricants also have the functions of reducing skin damage and resisting the invasion of bacteria and viruses.

[0003] In related technologies, there is a water-soluble personal lubricant which, by weight percentage, includes the following components: glycerol 38%, Tween-20 3%, sodium hyaluronate 0.1%, jasmine essential oil 0.2%, aloe essential oil 0.8%, and water 57.9%. Among them, Tween-20 solubilizes the essential oil, and sodium hyaluronate forms a water film around its own molecules through hydrogen bonding to play a certain lubricating role.

[0004] Regarding the above-mentioned related technologies, the inventor believes that in the personal lubricant described in the related technologies, the hydrophilic end of Tween-20 will form hydrogen bonds with sodium hyaluronate. After Tween-20 forms hydrogen bonds with sodium hyaluronate, the hydrophobic end of Tween-20 enhances the hydrophobicity of sodium hyaluronate, resulting in a decrease in the effect of sodium hyaluronate adsorbing water molecules, thereby limiting the lubricating effect of the personal lubricant. Summary of the Invention

[0005] In related technologies, the surfactant Tween-20 enhances the hydrophobicity of sodium hyaluronate, resulting in a decrease in the effect of sodium hyaluronate adsorbing water molecules, thereby limiting the lubricating effect of the personal lubricant. To improve this defect, this application provides a water-soluble personal lubricant and a preparation method thereof.

[0006] In the first aspect, this application provides a water-soluble personal lubricant, adopting the following technical solution:

[0007] A water-soluble personal lubricant, the personal lubricant is formed by mixing Agent A and Agent B. Agent A, by weight percentage, includes the following components: glycerol 30 - 47%, Tween-20 2 - 4%, sodium hyaluronate 0.05 - 0.15%, jasmine essential oil 0.1 - 0.3%, aloe essential oil 0.5 - 1.2%, preservative 0.5 - 0.8%, and the balance is made up to 100% with water; the components of Agent B include cyclodextrin.

[0008] By adopting the above technical solution, cyclodextrin has a cyclic structure with a hydrophobic interior and a hydrophilic exterior. By adding cyclodextrin to Agent B, the hydrophobic region inside the cyclodextrin can accommodate and adsorb the hydrophobic end of Tween-20, and the hydrophilic groups on the outer side of the cyclodextrin cyclic structure can associate with water molecules through hydrogen bonds. Thus, the influence of Tween-20 on the hydrophilicity of sodium hyaluronate is reduced, which helps to improve the lubricating performance of the human lubricant.

[0009] In addition, for the human lubricants that have been put into production in the related art, their components are consistent with Agent A of the present application. Therefore, the human lubricants produced according to the formula in the related art can be directly selected as Agent A of the present application, and the lubricating performance can be improved by adding Agent B on the basis of Agent A, which helps to reduce the inventory backlog of the old model human lubricants.

[0010] Preferably, the molar ratio of the cyclodextrin to Tween-20 is (2.4 - 2.8):1.

[0011] By adopting the above technical solution, the molar ratio of cyclodextrin to Tween-20 is optimized, and the influence of Tween-20 on the lubricating performance is fully reduced on the premise of saving raw materials.

[0012] Preferably, the components of Agent B further include chitosan and an acidifying agent, the pH of the human lubricant is 6.0 - 6.5, and the isoelectric point of sodium hyaluronate is 5.93.

[0013] By adopting the above technical solution, under the pH conditions defined in the present application, sodium hyaluronate is negatively charged, and the amino group of chitosan will be protonated, making chitosan positively charged. Therefore, chitosan can bind to sodium hyaluronate through electrostatic adsorption. Chitosan is rich in hydroxyl and amino groups and has good hydrophilicity, and can adsorb water molecules simultaneously with the molecules of sodium hyaluronate, increasing the thickness of the water film, which helps to improve the lubricating performance of the human lubricant.

[0014] Preferably, the dosage of the chitosan is 4.8 - 7.2 times the weight of sodium hyaluronate.

[0015] By adopting the above technical solution, the dosage of chitosan is optimized, which helps to fully improve the lubricating performance of the human lubricant on the premise of saving chitosan.

[0016] Preferably, the components of Agent B further include sodium tripolyphosphate.

[0017] By adopting the above technical solution, sodium tripolyphosphate is added to the formula system of the human lubricant in the present application. Sodium tripolyphosphate can undergo electrostatic adsorption with chitosan under the pH conditions defined in the present application and absorb water around sodium hyaluronate to form a hydrogel structure. The hydrogel structure has a certain lubricating effect and improves the lubricating performance of the human lubricant.

[0018] Preferably, the dosage of the sodium tripolyphosphate is 1.4 - 1.8 times the weight of the chitosan.

[0019] By adopting the above technical solution, the dosage of the sodium tripolyphosphate is optimized, which helps to fully improve the lubricating performance of the human lubricant on the premise of saving the sodium tripolyphosphate.

[0020] Preferably, the components of the agent B further include mucin.

[0021] By adopting the above technical solution, mucin is a complex protein formed by the combination of mucopolysaccharide and protein, and a large number of branched chains are distributed on the main chain. The branched chains of mucin contain abundant hydroxyl groups, carboxyl groups, sulfonic acid groups and amino groups, which can be assembled into the hydrogel through electrostatic adsorption, strengthening the ability of the hydrogel to bind water molecules and helping to improve the lubricating effect of the human lubricant.

[0022] Preferably, the dosage of the mucin is 2.4 - 5.2 times the weight of the chitosan.

[0023] By adopting the above technical solution, the dosage of the mucin is optimized, which helps to fully improve the lubricating effect of the human lubricant.

[0024] Preferably, the components of the agent B further include phospholipids.

[0025] By adopting the above technical solution, phospholipids can achieve lubrication by forming hydrated molecules in the system of the human lubricant, and can also play a lubricating role similar to that of a ball bearing during the friction process, helping to improve the lubricating effect of the human lubricant.

[0026] In the second aspect, the present application provides a preparation method of a water-soluble human lubricant, adopting the following technical solution.

[0027] A preparation method of a water-soluble human lubricant includes the following steps:

[0028] (1) Mix the agent A and the agent B, and obtain a dispersion after 3 - 5 h of mechanical stirring;

[0029] (2) Keep the dispersion at 55 - 65 °C for 1 - 2 h to obtain the water-soluble human lubricant.

[0030] By adopting the above technical solution, in the present application, the agent A and the agent B are first fully mixed by mechanical stirring, and then heat preservation treatment is carried out to obtain the water-soluble human lubricant.

[0031] In summary, the present application has the following beneficial effects:

[0032] 1. In the present application, the hydrophobic region at the center of the cyclodextrin molecule accommodates and adsorbs the hydrophobic end of Tween-20, and more hydrophilic groups are introduced around the Tween-20 molecule, reducing the impact of Tween-20 on the lubricating performance and improving the lubricating performance of the personal lubricant.

[0033] 2. In the present application, the preferred components of the B agent include chitosan and sodium tripolyphosphate, and a hydrogel is assembled around sodium hyaluronate through electrostatic adsorption, improving the lubricating performance of the personal lubricant. Detailed implementation manners

[0034] The present application will be further described in detail below with reference to examples and comparative examples. All raw materials involved in the present application are commercially available.

[0035] Examples

[0036] Examples 1-5

[0037] Taking Example 1 as an example for illustration below.

[0038] Example 1

[0039] In this example, the A agent includes the following components by weight percentage: glycerol 47%, Tween-20 4%, sodium hyaluronate 0.05%, jasmine essential oil 0.3%, aloe essential oil 1.2%, preservative 0.5%, water 46.95%, and the preservative is phenoxyethanol. The B agent is cyclodextrin, and the molar ratio of cyclodextrin to Tween-20 is 2.2:1.

[0040] In this example, the water-soluble personal lubricant is prepared according to the following steps:

[0041] (1) Mix the A agent and the B agent, and obtain a dispersion after 4 h of mechanical stirring;

[0042] (2) Keep the dispersion at 60 °C for 1.5 h to obtain the water-soluble personal lubricant.

[0043] As shown in Table 1, the differences between Examples 1-5 mainly lie in different raw material ratios.

[0044] Table 1 Mass fractions of each component in the A agent

[0045]

[0046] Examples 6-9

[0047] As shown in Table 2, the differences between Examples 6-9 and Example 3 are that the molar ratio of cyclodextrin to Tween-20 (hereinafter referred to as R 1 ) is different.

[0048] Table 2 Molar ratio of cyclodextrin to Tween-20

[0049]

[0050] Example 10

[0051] The difference between this example and Example 9 is that the components of Agent B further include chitosan and an acidifying agent, and the acidifying agent is succinic acid. The final pH of the water-soluble personal lubricant is 6.2 (the dosage of succinic acid is determined according to this pH condition), and the dosage of chitosan is 3.5 times the weight of sodium hyaluronate.

[0052] As shown in Table 3, the difference between Examples 10 - 14 is that the dosage of chitosan is different multiples of the weight of sodium hyaluronate (hereinafter referred to as T 1 ).

[0053] Table 3 Dosage of chitosan

[0054]

[0055] Example 15

[0056] The difference between this example and Example 14 is that the components of Agent B further include sodium tripolyphosphate, and the dosage of sodium tripolyphosphate is 1.2 times the weight of chitosan.

[0057] As shown in Table 4, the difference between Examples 15 - 19 is that the dosage of sodium tripolyphosphate is different multiples of the weight of chitosan (hereinafter referred to as T 2 ).

[0058] Table 4 Dosage of sodium tripolyphosphate

[0059]

[0060] Example 20

[0061] The difference between this example and Example 17 is that the components of Agent B further include mucin, and the dosage of mucin is 2.0 times the weight of chitosan.

[0062] As shown in Table 5, the difference between Examples 20 - 24 is that the dosage of mucin is different multiples of the weight of chitosan (hereinafter referred to as T 3 ).

[0063] Table 5 Dosage of mucin

[0064]

[0065] Example 25

[0066] The difference between this example and Example 22 is that the components of Agent B further include phospholipids, and the dosage of phospholipids is 20% of the weight of mucin.

[0067] Comparative Example

[0068] Comparative Example 1

[0069] A water-soluble personal lubricant, comprising the following components by weight percentage: 38% glycerol, 3% Tween-20, 0.1% sodium hyaluronate, 0.2% jasmine essential oil, 0.8% aloe essential oil, and 57.9% water.

[0070] The water-soluble personal lubricant is prepared by the following method:

[0071] (1) Add glycerol and sodium hyaluronate to water at 70 °C, and stir and mix to obtain an aqueous phase, which is kept warm for standby;

[0072] (2) Mix jasmine essential oil, aloe essential oil and Tween-20 evenly to obtain an oil phase;

[0073] (3) While stirring the oil phase, add the aqueous phase to the oil phase to obtain an emulsion. After the emulsion is cooled to room temperature, the water-soluble personal lubricant can be obtained.

[0074] Comparative Example 2

[0075] The difference between this comparative example and Example 3 is that the components of the water-soluble personal lubricant do not include Tween-20.

[0076] Performance Detection Test Method

[0077] Referring to "ASTM D5183-2005(2011) Test Method for Determining the Friction Coefficient of Lubricating Oil Using a Four-Ball Wear Tester", use the water-soluble personal lubricants of each example and comparative example to replace the lubricating oil as samples, and detect the friction coefficient, and then calculate the ratio between the friction coefficient of each example and comparative example and the friction coefficient of Comparative Example 1. This ratio is recorded as the relative friction coefficient, and the results are shown in Table 6.

[0078] Table 6 Calculation Results of Relative Friction Coefficient

[0079] Sample Relative friction factor / % Sample Relative friction factor / % Example 1 89.4 Example 15 74.2 Example 2 87.9 Example 16 72.8 Example 3 86.2 Example 17 70.5 Example 4 84.7 Example 18 68.9 Example 5 83.4 Example 19 68.5 Example 6 84.2 Example 20 67.6 Example 7 82.9 Example 21 65.3 Example 8 82.4 Example 22 64.4 Example 9 82.2 Example 23 64.1 Example 10 80.5 Example 24 63.9 Example 11 78.6 Example 25 61.7 Example 12 77.9 Comparative Example 1 100.0 Example 13 77.6 Comparative Example 2 81.8 Example 14 77.5 / /

[0080] Combined with Examples 1-5 and Comparative Example 1 and combined with Table 6, it can be seen that the relative friction coefficients measured in Example 3 are all less than those in Comparative Example 1, indicating that by adding cyclodextrin to Agent B, the hydrophobic region inside the cyclodextrin can accommodate and adsorb the hydrophobic end of Tween-20, and the hydrophilic groups on the outer side of the cyclodextrin ring structure can associate with water molecules through hydrogen bonds. Thus, the influence of Tween-20 on the hydrophilicity of sodium hyaluronate is reduced, which helps to improve the lubricating performance of the personal lubricant. The relative friction coefficients measured in Examples 1-5 are all less than those in Comparative Example 1 and decrease in turn, indicating that reducing the dosage of Tween-20 can reduce the influence of Tween-20 on the hydrophobicity of sodium hyaluronate.

[0081] Combined with Comparative Examples 1-2 and Table 6, it can be seen that the relative friction coefficient measured in Comparative Example 1 is greater than that in Comparative Example 2, indicating that in Comparative Example 1, Tween-20 affected the hydrophilicity of sodium hyaluronate, resulting in a decrease in the lubricating performance of the personal lubricant.

[0082] Combined with Example 3 and Examples 6-9 and Table 6, it can be seen that the relative friction coefficients measured in Example 3 and Examples 6-9 gradually decreased, indicating that increasing the amount of cyclodextrin within the range of the molar ratio of cyclodextrin to Tween-20 being (2.2-3.0):1 is helpful for obtaining a personal lubricant with better lubricating performance. As the amount of cyclodextrin increases, the relative friction coefficient does not decrease linearly. Among Example 3 and Examples 6-9, the relative friction coefficient measured in Example 3 is relatively high, while the relative friction coefficient measured in Example 9 is close to that in Example 8, indicating that the cyclodextrin in Example 3 did not fully exert its effect, while the cyclodextrin in Example 8 has fully taken effect. After optimization, when the molar ratio of cyclodextrin to Tween-20 is (2.4-2.8):1, the lubricating performance of the personal lubricant is relatively good, and the cyclodextrin is not significantly in excess.

[0083] Combined with Example 9 and Examples 10-14 and Table 6, it can be seen that the relative friction coefficients measured in Examples 10-14 gradually decreased and were all less than that in Example 9, indicating that after adding chitosan under acidic conditions, chitosan is combined with sodium hyaluronate through electrostatic adsorption. Chitosan is rich in hydroxyl and amino groups and has good hydrophilicity, and can adsorb water molecules simultaneously with the molecules of sodium hyaluronate, increasing the thickness of the water film, which is helpful for improving the lubricating performance of the personal lubricant. The relative friction coefficients of Examples 10-14 do not show a linear pattern when decreasing, and the change rate of the relative friction coefficient with respect to the amount of chitosan gradually decreases as the amount of chitosan increases, indicating that the adsorption between sodium hyaluronate and chitosan gradually tends to saturation. After optimization, when the amount of chitosan is 4.8-7.2 times the weight of sodium hyaluronate, the lubricating performance of the personal lubricant can be relatively fully improved on the premise of saving chitosan.

[0084] Combined with Example 14 and Examples 15-19 and Table 6, it can be seen that the relative friction coefficients measured in Examples 15-19 gradually decreased and were all less than that in Example 14, indicating that sodium tripolyphosphate can undergo electrostatic adsorption with chitosan under the pH conditions defined in this application and absorb water around sodium hyaluronate to form a hydrogel structure. Since the hydrogel structure has a certain lubricating effect, the measured friction coefficient is reduced, improving the lubricating performance of the personal lubricant. After optimization, when the amount of sodium tripolyphosphate is 1.4-1.8 times the weight of chitosan, the lubricating performance of the personal lubricant can be relatively fully improved on the premise of saving sodium tripolyphosphate.

[0085] Combined with Example 17, Examples 20 - 24 and Table 6, it can be seen that the relative friction coefficients measured in Examples 20 - 24 gradually decreased, and mucin could be assembled into the hydrogel through electrostatic adsorption, strengthening the ability of the hydrogel to bind water molecules, which helped to improve the lubrication effect of the human lubricant. After optimization, when the dosage of mucin was 2.4 - 5.2 times the weight of chitosan, it could meet the premise of saving mucin and achieve relatively good lubrication performance.

[0086] Combined with Example 22, Example 25 and Table 6, it can be seen that after adding phospholipids on the basis of the formulation of Example 22, phospholipids can not only achieve lubrication by forming hydrated molecules, but also play a lubricating role similar to that of a ball bearing during the friction process, which helps to improve the lubrication effect of the human lubricant.

[0087] This specific embodiment is only an interpretation of the present application, and it does not limit the present application. Those skilled in the art can make modifications to this embodiment without creative contributions according to needs after reading this specification, but as long as it is within the scope of the claims of the present application, it is protected by the patent law.

Claims

1. A water-soluble personal lubricant, characterized in that, the personal lubricant is formed by mixing Agent A and Agent B. Agent A includes the following components by weight percentage: glycerol 30-47%, Tween-20 2-4%, sodium hyaluronate 0.05-0.15%, jasmine essential oil 0.1-0.3%, aloe essential oil 0.5-1.2%, preservative 0.5-0.8%, and the balance is made up to 100% with water; the components of Agent B include cyclodextrin, and the molar ratio of cyclodextrin to Tween-20 is (2.4-2.8):1; the components of Agent B also include mucin, and the dosage of mucin is 2.4-5.2 times the weight of chitosan.

2. The water-soluble personal lubricant according to claim 1, characterized in that, the components of Agent B also include chitosan and acidifying agent, the pH of the personal lubricant is 6.0-6.5, and the isoelectric point of sodium hyaluronate is 5.

93.

3. The water-soluble personal lubricant according to claim 2, characterized in that, the dosage of chitosan is 4.8-7.2 times the weight of sodium hyaluronate.

4. The water-soluble personal lubricant according to claim 2, characterized in that, the components of Agent B also include sodium tripolyphosphate.

5. The water-soluble personal lubricant according to claim 4, characterized in that, the dosage of sodium tripolyphosphate is 1.4-1.8 times the weight of chitosan.

6. The water-soluble personal lubricant according to claim 1, characterized in that, the components of Agent B also include phospholipid.

7. The preparation method of the water-soluble personal lubricant according to any one of claims 1-6, characterized in that, comprises the following steps: (1) Mix Agent A and Agent B, and obtain a dispersion after 3-5 hours of mechanical stirring; (2) Keep the dispersion at 55-65 °C for 1-2 hours to obtain the water-soluble personal lubricant.

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