Interventional thrombolytic therapy infusion device

Abstract

The application provides an interventional thrombolytic treatment perfusion device, which comprises a catheter and a guide wire, wherein the guide wire comprises a guide wire connecting assembly, a spring, a guide wire body, a plug and a guide wire soft segment connected in sequence, the guide wire passes through the catheter and is fixed with one end of the catheter through the guide wire connecting assembly, and the plug closes the other end of the catheter under the action of the spring. Compared with the prior art, the interventional thrombolytic treatment perfusion device of the application avoids the falling of the guide wire during use, avoids the damage to the blood vessel when the catheter enters the thrombus, and makes the distribution of the drug at the thrombus more uniform and the release more accurate, so that the effect of fast, uniform and accurate thrombolytic treatment is achieved.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of thrombolytic therapy, and particularly relates to an interventional thrombolytic therapy perfusion device. BACKGROUND

[0002] A thrombus is mainly composed of insoluble fibrin, deposited platelets, accumulated white blood cells and trapped red blood cells. Vascular embolism is a common disease in vascular diseases, for example, peripheral vascular thrombosis, etc. If not treated in time, it will cause disability, and even threaten life. At present, the treatment of vascular embolism mainly includes anticoagulation, drug thrombolysis, surgery, mechanical thrombectomy, etc.

[0003] However, at present, anticoagulation, drug thrombolysis, surgery and mechanical thrombectomy have their limitations and shortcomings.

[0004] The interventional thrombolytic therapy perfusion catheter can solve the limitations and shortcomings of anticoagulation and surgical treatment. The interventional thrombolytic therapy perfusion catheter enters the thrombus under the guidance of a guide wire, and the thrombolytic drug is injected into the catheter at a certain speed and injected into the thrombus in the form of high-pressure penetration from the side multi-hole of the catheter; a small amount of thrombolytic drug can achieve the purpose of rapid thrombolysis treatment.

[0005] However, the interventional thrombolytic therapy perfusion catheter used on the market has the problems that the guide wire is easy to fall off; the front end of the matching guide wire of the catheter is relatively soft, but not super smooth, and it is easy to cause damage to the blood vessel when entering the thrombus; in addition, after the existing thrombolytic catheter injects the thrombolytic drug, the thrombolytic drug is mainly distributed in the contact part of the thrombus and the catheter, and cannot uniformly penetrate into the inside of the thrombus. In this way, the thrombolysis efficiency is low, the amount of thrombolytic drug is large, and the large amount of thrombolytic drug has the risk of bleeding. SUMMARY

[0006] In view of the problems of the prior art that the guide wire is easy to fall off, the catheter causes damage to the blood vessel when entering the thrombus, and the drug is not evenly distributed at the thrombus, and the large amount of drug leads to the problems, the present application provides an interventional thrombolytic therapy perfusion device.

[0007] Specifically, the present application relates to the following aspects:

[0008] 1. An interventional thrombolytic therapy perfusion device, characterized in that the perfusion device comprises a catheter and a guide wire, wherein the guide wire comprises a guide wire connecting assembly, a spring, a guide wire body, a plug and a guide wire soft section connected in sequence, the guide wire passes through the catheter and is fixed to one end of the catheter through the guide wire connecting assembly, and the plug closes the other end of the catheter under the action of the spring.

[0009] 2. The perfusion device according to claim 1, wherein the guide wire connecting assembly comprises a guide wire connector, a first sleeve and a second sleeve, wherein the guide wire connector has an inner cavity, one end of the first sleeve has a shoulder which is clamped in the guide wire connector to limit the movement of the first sleeve to the distal end of the guide wire connector, the second sleeve is sleeved on the first sleeve and clamped in the guide wire connector to limit the movement of the first sleeve to the proximal end of the guide wire connector, and the first sleeve is connected with the spring.

[0010] 3. The perfusion device according to claim 1, wherein the surface of the guide wire soft section has a super-smooth coating.

[0011] 4. The perfusion device according to claim 2, wherein the catheter comprises a catheter connector, a catheter body and a catheter tip which are connected in sequence, wherein the catheter connector is connected with the guide wire connector, and the plug seals the catheter tip.

[0012] 5. The perfusion device according to claim 4, wherein the surface of the catheter body is provided with two catheter marks, and a liquid outlet hole is arranged between the two catheter marks.

[0013] 6. The perfusion device according to claim 5, wherein the liquid outlet hole is circular and has a diameter of 0.1-0.3 mm.

[0014] 7. The perfusion device according to claim 5, wherein the liquid outlet hole is 100-300, and preferably the liquid outlet holes are uniformly distributed.

[0015] 8. The perfusion device according to claim 1, wherein the plug has a vertebral surface shoulder.

[0016] 9. The perfusion device according to claim 4, wherein the guide wire connector and the catheter connector are connected by threads.

[0017] 10. The perfusion device according to claim 4, wherein the outer diameter of the catheter tip is smaller than the outer diameter of the catheter body.

[0018] 11. The perfusion device according to claim 1, further comprising a pressurized injection device, wherein the pressurized injection device is connected with the guide wire to inject medicine.

[0019] 12. The perfusion device according to claim 1, wherein the pressurized injection device comprises a pressurized piston, a pressurized push handle, a return spring, a nut, a pressurized handle, a mounting frame, a syringe and a diaphragm.

[0020] The intervention thrombolytic treatment perfusion device of the present application avoids the falling of the guide wire during use, avoids the damage to the blood vessel when the catheter enters the thrombus, and makes the drug more evenly distributed at the thrombus and accurately released, so as to achieve the effect of rapid and accurate treatment. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 It is a front view of the intervention thrombolytic treatment perfusion device.

[0022] Figure 2 It is a guide wire diagram of the intervention thrombolytic treatment perfusion device.

[0023] Figure 3 It is a catheter diagram of the intervention thrombolytic treatment perfusion device.

[0024] Figure 4 It is a schematic diagram of the pressure injection device.

[0025] REFERENCE NUMERALS:

[0026] 1 catheter, 2 guide wire, 3 catheter mark, 4 catheter body, 5 first sleeve, 6 second sleeve, 7 spring, 8 catheter tip, 9 plug, 10 soft section, 11 guide wire connector, 12 catheter connector, 13 guide wire body, 14 pressure boosting piston, 15 pressure boosting handle, 16 return spring, 17 nut, 18 pressure boosting handle, 19 mounting bracket, 20 syringe, 21A port, 22 diaphragm, 23B port. DETAILED DESCRIPTION

[0027] The present application will be further described below in conjunction with the embodiments. It should be understood that the embodiments are only used to further illustrate and explain the present application, and are not used to limit the present application.

[0028] The technical solutions of the present application will be described below in conjunction with the embodiments. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0029] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only used for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", "third" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance.

[0030] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0031] Based on the description of the background art, the existing intervention thrombolytic therapy perfusion catheter has the problems of easy falling of the guide wire, often causing damage to the blood vessel when the catheter enters the thrombus, and uneven distribution of the drug at the thrombus site. In order to solve these problems, the present application provides an intervention thrombolytic therapy perfusion device, the perfusion device comprises a catheter and a guide wire, wherein the guide wire comprises a guide wire connecting assembly, a spring, a guide wire body, a plug and a guide wire soft segment connected in sequence, wherein the guide wire passes through the catheter and is fixed with one end of the catheter through the guide wire connecting assembly, and the plug closes the other end of the catheter under the action of the spring.

[0032] As shown in Figures 1-3 The intervention thrombolytic therapy perfusion device of the present application comprises a catheter 1 and a guide wire 2, the guide wire 2 passes through the catheter 1 and is fixed with the catheter 1, wherein the guide wire 2 comprises a guide wire connecting assembly, a spring 7, a guide wire body 13, a plug 9 and a guide wire soft segment 10 connected in sequence, wherein the guide wire 2 passes through the catheter 1 and is fixed with one end of the catheter 2 through the guide wire connecting assembly, the plug 9 is a columnar structure with a conical shoulder, and closes the other end of the catheter 1 under the action of the spring 7. The guide wire 2 plays a role of introduction, support, opening and exchange in vascular intervention treatment. The functions of the guide wire 2 include: guiding and supporting the catheter to pass through soft tissues such as subcutaneous tissue and blood vessel wall, and entering the blood vessel through the puncture hole; guiding the catheter to pass through the tortuous and hardened blood vessel, and selectively or superselectively entering the examined blood vessel branch; strengthening the hardness of the catheter, which is beneficial to the operation of the catheter; making exchange of the catheter; the soft head end can reduce the damage of the catheter to the blood vessel intima. The catheter 1 is used for storing drugs in vascular intervention treatment, and releasing the drugs at the specified site.

[0033] Among them, the guide wire body 13 is a columnar structure, and the material is a soft and corrosion-resistant material, for example, it can be a nickel-titanium alloy. The head end of the guide wire soft segment 10, i.e. the guide wire 2, is a columnar structure, which is used to guide the catheter to smoothly enter the blood vessel thrombus site, and the material is a soft and corrosion-resistant material, which can reduce the damage to the blood vessel intima, for example, it can be a nickel-titanium alloy.

[0034] The nickel-titanium alloy is a shape memory alloy, which can automatically restore the original shape at a certain temperature. Its stretching rate is more than 20%, the fatigue life is 1*10 7, the damping characteristic is 10 times higher than that of ordinary spring, and the corrosion resistance is better than the best medical stainless steel. Therefore, it can meet the application requirements of various engineering and medicine, and is a very excellent functional material. In addition to the unique shape memory function, the nickel-titanium alloy also has excellent characteristics such as wear resistance, corrosion resistance, high damping and super elasticity.

[0035] Further, as shown in Figure 2 The guide wire connecting assembly includes a guide wire connecting head 11, a first sleeve 5 and a second sleeve 6, wherein the guide wire connecting head 11 has an internal cavity, one end of the first sleeve 5 is provided with a shoulder, which is clamped in the guide wire connecting head 11 to limit the movement of the first sleeve 5 to the distal end of the guide wire connecting head 11, the second sleeve 6 is sleeved on the first sleeve and clamped in the guide wire connecting head to limit the movement of the first sleeve 5 to the proximal end of the guide wire connecting head 11, and the first sleeve 5 is connected with the spring 7. Wherein, the "proximal end" used in the present application refers to the end close to the operator of the thrombolytic therapy perfusion device, and the "distal end" refers to the end away from the operator of the thrombolytic therapy perfusion device.

[0036] As shown in Figure 3 The catheter 1 includes a catheter connecting head 12, a catheter body 4 and a catheter tip 8 connected in sequence, wherein the catheter connecting head 12 is connected with the guide wire connecting head 11, and the plug 9 seals the catheter tip 8. The catheter body 4 is used for injecting drugs, and is a hollow tubular structure with an inner diameter larger than the diameter of the guide wire body 13, so that the guide wire body 13 can pass through. The material is a corrosion-resistant material, for example, it can be Teflon and 304 stainless steel. The catheter tip 8 is a hollow column structure in communication with the catheter body 4, and the material is a corrosion-resistant material, for example, it can be Teflon.

[0037] The guide wire connecting assembly serves as a connection with the catheter and the drug injection equipment, and is a hollow structure as a whole. The drug enters the catheter through the guide wire connecting assembly. Specifically, the guide wire connecting assembly is connected with the catheter connecting head 12 of the catheter 1 through the guide wire connecting head 11. The drug injection equipment can be various forms of injection devices, for example, it can be a booster injection device. Two steps are designed in the cavity of the guide wire connecting head 11, wherein the proximal step cooperates with the shoulder of the first sleeve 5, so that the first sleeve 5 is clamped at the proximal step to limit the movement of the first sleeve 5 to the distal end of the guide wire connecting head 11, that is, to limit the movement of the first sleeve 5 to the distal end of the guide wire connecting head 11. Figure 2The direction shown is an example of limiting the first sleeve 5 from moving right relative to the guide wire connector 11. The distal end step cooperates with the second sleeve 6, which is sleeved on the first sleeve 5, to be fixed, for example, by welding, bonding or other fixing methods, and to make the second sleeve 6 clamped at the distal end step, so as to limit the first sleeve 5 from moving proximally relative to the guide wire connector 11, that is, to limit the first sleeve 5 from moving left relative to the guide wire connector 11. Figure 2 The direction shown is an example of limiting the first sleeve 5 from moving right relative to the guide wire connector 11. The distal end step cooperates with the second sleeve 6, which is sleeved on the first sleeve 5, to be fixed, for example, by welding, bonding or other fixing methods, and to make the second sleeve 6 clamped at the distal end step, so as to limit the first sleeve 5 from moving proximally relative to the guide wire connector 11, that is, to limit the first sleeve 5 from moving left relative to the guide wire connector 11.

[0038] The guide wire connector 11 and the catheter connector 12 can be connected by any possible way in the prior art. In a specific embodiment, the guide wire connector 11 and the catheter connector 12 are connected by screwing.

[0039] The spring 7 is used to tightly connect the plug 9 with the catheter end 8, so as to close the catheter end 8 and avoid the leakage of the drug from the catheter end 8, thereby ensuring that the drug can be released at the designated position of the catheter 1. The outer diameter of the catheter end 8 is smaller than the inner diameter of the catheter body 4, so that the guide wire soft body segment 10 of the guide wire 2 can pass through the catheter end 8. Meanwhile, the plug 9 is designed with a conical shoulder, so as to close the catheter end 8. The plug 9 is made of a flexible and corrosion-resistant material, for example, a nickel-titanium alloy.

[0040] In a specific embodiment, the surface of the guide wire soft body segment 10 is provided with a super-smooth layer, which is used to reduce the friction between the interventional thrombolytic therapy perfusion device and the blood vessel, so that the guide wire can smoothly enter the blood vessel and reduce the damage to the blood vessel intima. The material of the super-smooth layer can be, for example, Teflon. Teflon is an alias of Polytetrafluoroethylene. The products of this material are generally collectively referred to as "non-stick coating". It is a kind of artificially synthesized polymer material which uses fluorine to replace all hydrogen atoms in polyethylene. This material has the characteristics of resisting acid and alkali and resisting various organic solvents, and is almost insoluble in all solvents. At the same time, Polytetrafluoroethylene has the characteristics of high temperature resistance, and its friction coefficient is extremely low, so it can be used as a lubricating way. The Teflon coating has a low friction coefficient. This material makes the interventional thrombolytic therapy perfusion device enter the blood vessel smoothly and safely, avoiding the device from scratching the blood vessel.

[0041] Further, two catheter marks 3 are arranged on the surface of the catheter body 4, and liquid outlets are arranged between the two catheter marks 3. The distance between the two catheter marks 3 is 10-50 cm, and the liquid outlets are arranged between the two catheter marks 3.

[0042] The liquid outlets are used for the outflow of the drug, so that the drug reaches the thrombus site and achieves the purpose of thrombolysis. In this embodiment, the liquid outlets are arranged between the two catheter marks 3, and no liquid outlets are arranged in other parts, so that the drug can only be released between the two catheter marks 3. When the perfusion device is used in interventional thrombolysis treatment, the operator can accurately place the liquid outlets in the thrombus site by observing the positions of the two catheter marks 3, so as to achieve accurate release of the drug.

[0043] The arrangement of the liquid outlets on the catheter body 4 can be flexibly arranged according to actual needs. Specifically, the shape of the liquid outlet can be flexibly arranged, such as a circular shape, an elliptical shape, a square shape, a polygonal shape, or an irregular shape. The size of the liquid outlet can also be flexibly arranged. In a specific embodiment, the liquid outlet is circular, and the diameter of the liquid outlet is 0.1-0.3 mm, for example, 0.05 mm, 0.1 mm, 0.15 mm, 0.2 mm, 0.25 mm, or 0.3 mm. The number of liquid outlets can also be flexibly arranged. In a specific embodiment, the number of liquid outlets is 100-200, for example, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, or 200. The shapes, sizes, and distances of the plurality of liquid outlets can be the same or different. Preferably, the plurality of liquid outlets are uniformly distributed, so that the distribution of the drug at the thrombus site is more uniform.

[0044] In a specific embodiment, the catheter body 4 is uniformly distributed with multiple rows of liquid outlets in the axial direction, for example, 5 rows, 10 rows, 20 rows, 30 rows, 40 rows, or 50 rows. The distance between each row of liquid outlets is the same, for example, 3-5 mm. Each row of liquid outlets is provided with a plurality of liquid outlets uniformly distributed in the radial direction of the catheter body 4, for example, 2 holes, 3 holes, 4 holes, 5 holes, or 6 holes.

[0045] In a specific embodiment, the catheter body 4 is uniformly distributed with 40 rows of liquid outlets in the axial direction, each hole is circular, and the diameter of the hole is 0.15 mm. The distance between each row of liquid outlets is 3 mm. Each row of liquid outlets is provided with 4 liquid outlets uniformly distributed in the radial direction of the catheter body 4.

[0046] In a specific embodiment, the catheter body 4 is uniformly distributed with 30 rows of liquid outlets in the axial direction, each hole is circular, and the diameter of the hole is 0.2 mm. The distance between each row of liquid outlets is 5 mm. Each row of liquid outlets is provided with 3 liquid outlets uniformly distributed in the radial direction of the catheter body 4.

[0047] In one specific embodiment, the catheter body 4 has 50 axially uniformly distributed discharge holes, each of which is circular and has a diameter of 0.1 mm. The distance between each discharge hole is 4 mm. Five liquid outlet holes are arranged in each discharge hole and are uniformly distributed along the radial direction of the catheter body 4.

[0048] In use, the catheter 1 is guided by the guide wire 2 into the blood vessel so that the thrombus is located between the two catheter markers 3. Then the guide wire 2 is inserted into the catheter 1, the catheter connector 12 is connected to the tail end of the guide wire connector 11, the drug injection device (syringe) is inserted into the guide wire connector 11, and the drug is injected. The drug enters the guide wire connector 11 through the injection pressure, flows into the catheter 1 through the first sleeve 5, and is released by the liquid outlet holes on the catheter body 4 to spray onto the thrombus site, achieving the therapeutic effect.

[0049] The pressurized injection device can be any known and suitable pressurized injection device in the prior art. Figure 4 Fig. 1 is a schematic view of a pressurized injection device. The pressurized injection device comprises a pressurized piston 14, a pressurized push handle 15, a return spring 16, a nut 17, a pressurized handle 18, a mounting frame 19, a syringe 20, and a diaphragm 22. The pressurized piston 14 is located in the mounting frame 19, with the left side of the piston connected to the piston connection port (not shown) in the mounting frame 19 and the right side connected to the left side of the pressurized push handle 15. The left side of the return spring 16 is connected to the nut 17, and the right side is located inside the pressurized handle 18. The pressurized push handle 15 passes through the return spring 16 and is located on the right side of the pressurized handle 18. The pressurized handle 18 is mounted to the mounting frame 19 through the nut 17. The mounting frame 19 also has a movable diaphragm 22.

[0050] The mounting frame 19 has an A port 21 and a B port 23. The A port 21 is used to connect to the syringe 20 for injecting the drug, and the B port 23 is connected to the guide wire 2. Specifically, the B port 23 is connected to the connector 11 of the guide wire 2. When the return spring 16 pulls the pressurized piston 14 through the pressurized push handle 15, a negative pressure is generated in the pressurized injection device, the diaphragm 22 is pulled up, and the liquid drug enters the pressurized injection device. Then the pressurized handle 18 is pushed, the pressurized piston 14 is pushed through the pressurized push handle 15, the diaphragm 22 is pulled down at this time, the syringe port A port 21 is blocked, and the liquid drug enters the guide wire 2 from the B port 23. Because the area of the pressurized piston 14 of the pressurized injection device is smaller than the area of the syringe piston, a larger pressure can be generated to spray the drug from the interventional thrombolytic treatment perfusion device into the thrombus and cut the thrombus. The use of this pressurized injection device has the following advantages: 1. Easy to push and spray for medical personnel; 2. The liquid drug can be sprayed into the deep area of the thrombus; 3. The thrombus is cut; 4. The sterile pressurizer can be replaced, and the mechanism part can be repeatedly used; 5. The operation is simple.

[0051] Example 1

[0052] like Figures 1-3 As shown, an interventional thrombolysis infusion device includes a catheter 1 and a guidewire 2. The guidewire 2 includes a guidewire connection assembly, a spring 7, a guidewire body 13, a plug 9, and a guidewire soft segment 10 connected in sequence. The guidewire connection assembly includes a guidewire connector 11, a first sleeve 5, and a second sleeve 6. The guidewire connector 11 has an internal cavity. One end of the first sleeve 5 has a shoulder, which is used to lock the first sleeve 5 within the guidewire connector 11 to restrict its distal movement relative to the guidewire connector 11. The second sleeve 6 is fitted onto the first sleeve and locked within the guidewire connector to restrict the first sleeve 5 from proximal movement relative to the guidewire connector 11. The first sleeve 5 is connected to the spring 7. The guidewire body 13 has a cylindrical structure with a diameter of 0.5 mm and is made of nickel-titanium alloy. The plug 9 has a cylindrical structure with a conical shoulder and is also made of nickel-titanium alloy. The guidewire soft segment 10 has a columnar structure, is made of nickel-titanium alloy, and has a super-slippery layer on its surface, which is made of Teflon.

[0053] The catheter 1 includes a catheter connector 12, a catheter body 4, and a catheter tip 8 connected in sequence. The catheter connector 12 is threadedly connected to the guidewire connector 11, and the plug 9 seals the catheter tip 8. The catheter body 4 is a hollow tubular structure with an inner diameter of 1.4 mm, and is made of Teflon and 304 stainless steel. The catheter tip 8 is a hollow cylindrical structure communicating with the catheter body 4, and is made of Teflon.

[0054] Two catheter markings 3 are provided on the surface of the catheter body 4. The distance between the two markings 3 is 10cm-50cm. An outlet hole is provided between the two catheter markings 3.

[0055] The liquid outlet is circular with a diameter of 0.15 mm. Forty liquid outlet holes are evenly distributed between the two guide tube markings 3, with each outlet hole spaced 3 mm apart. Each outlet hole contains four outlet holes evenly distributed radially along the guide tube body 4.

[0056] Interventional thrombolysis perfusion device also includes Figure 4The shown pressurized injection device. The pressurized injection device comprises a pressurized piston 14, a pressurized push handle 15, a reset spring 16, a nut 17, a pressurized handle 18, a mounting frame 19, a syringe 20, a diaphragm 22. Among them, the pressurized piston 14 is located in the mounting frame 19, the left side is located in the piston connecting port (not shown) in the mounting frame 19, and the right side is connected with the left side of the pressurized push handle 15. The left side of the reset spring 16 is connected with the nut 17, and the right side is located in the inside of the pressurized handle 18. The pressurized push handle 15 passes through the reset spring 16, and the right side abuts against the inside of the pressurized handle 18. The pressurized handle 18 is installed on the mounting frame 19 through the nut 17. The mounting frame 19 is also provided with a movable diaphragm 22. The mounting frame 19 has an A port 21 and a B port 23, wherein the A port 21 is used to connect with the syringe 20 to inject drugs, and the B port 23 is connected with the connecting head 11.

[0057] The above is only the preferred embodiment of the present application, not any form of the present application, although the present application has been disclosed as above, however, not to limit the present application, any skilled in the art, without departing from the scope of the present application, when the above disclosed technical content can be made some changes or modifications for equivalent embodiments, but any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present application, all still belong to the scope of the present application technical scheme.

Claims

1. An interventional thrombolytic treatment infusion device, characterized in that, The perfusion device comprises a catheter and a guide wire, wherein the guide wire comprises a guide wire connecting assembly, a spring, a guide wire body, a plug and a guide wire soft segment connected in sequence, the guide wire passes through the catheter and is fixed with one end of the catheter through the guide wire connecting assembly, the plug closes the other end of the catheter under the action of the spring, The guide wire connecting assembly comprises a guide wire connecting head, a first sleeve and a second sleeve, wherein the guide wire connecting head has an internal cavity, the cavity has a proximal step and a distal step, one end of the first sleeve has a shoulder, the proximal step cooperates with the shoulder to make the shoulder be clamped at the proximal step to limit the first sleeve from moving to the distal end of the guide wire connecting head, the second sleeve is sleeved on the first sleeve and cooperates with the distal step to make the second sleeve be clamped at the distal step to limit the first sleeve from moving to the proximal end of the guide wire connecting head, and the first sleeve is connected with the spring, The catheter comprises a catheter connecting head, a catheter body and a catheter tip connected in sequence, wherein the catheter connecting head is connected with the guide wire connecting head, and the plug closes the catheter tip, The materials of the guide wire body, the plug and the guide wire soft segment are nickel-titanium alloy.

2. The interventional thrombolytic treatment perfusion device of claim 1, wherein, The surface of the guide wire soft segment has a super-smooth coating.

3. The perfusion device of claim 1, wherein, The surface of the catheter body is provided with two catheter marks, and a liquid outlet hole is arranged between the two catheter marks.

4. The perfusion device of claim 3, wherein, The liquid outlet hole is circular with a diameter of 0.1-0.3mm.

5. The perfusion device of claim 3, wherein, The liquid outlet hole is 100-300.

6. The perfusion device of claim 3, wherein, The liquid outlet holes are uniformly distributed.

7. The perfusion device of claim 1, wherein, The plug has a vertebral surface shoulder.

8. The perfusion device of claim 1, wherein, The guide wire connecting head is connected with the catheter connecting head through threads.

9. The perfusion device of claim 1, wherein, The outer diameter of the catheter tip is smaller than that of the catheter body.

10. The perfusion device of claim 1, wherein, The perfusion device further comprises a pressurized injection device, which is connected with the guide wire to inject medicine.

11. The perfusion device of claim 10, wherein, The pressurized injection device comprises a pressurized piston, a pressurized push handle, a return spring, a nut, a pressurized handle, a mounting frame, a syringe and a diaphragm.

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