A nutritional supplement capable of improving anemia in women during menstrual period, and its preparation method and application

Abstract

The present invention relates to the field of food technology, and provides a nutritional supplement, a preparation method and an application thereof. The nutritional supplement has the effects of warming yang and strengthening the body, and improving sub-health conditions such as anemia, irregular menstruation, low immunity and fatigue in women during the physiological period. Its composition includes high-content curcumin, iron porphyrin, turmeric, ginger powder, lactitol, and composite probiotic powder. The present invention also provides a nutritional supplement tablet and a preparation method thereof. At the same time, it also provides an application of a nutritional supplement or a nutritional supplement tablet in the preparation of health food or special medical food.

Description

Technical Field

[0001] The present invention relates to the technical field of health food, in particular to a nutritional supplement having the functions of warming yang and strengthening the body, improving anemia and menstrual disorders in women during their physiological period, and a preparation method and application thereof. Background Art

[0002] With the continuous improvement of people's living standards, people's diets are becoming more and more abundant, and people's dietary structure has undergone some changes. Unreasonable diet has led to an increasing number of people suffering from diseases of affluence. People are beginning to suffer from sub-health and are paying more and more attention to healthy diet and health care.

[0003] Actively promote the overall improvement of public nutrition and health, continuously enhance the precision manufacturing technology level and development capabilities of healthy foods, and urgently need scientific and technological leadership in the targeted design of nutritional balance and targeted regulation of health intervention, as well as the development of functional health foods and special nutritional foods. Therefore, the market prospects for the development of different types of functional foods are very broad.

[0004] According to statistics from the World Health Organization, there are about 3 billion people with varying degrees of anemia in the world. Every year, tens of millions of people die from various diseases caused by anemia. Statistics from the World Health Organization show that the incidence of anemia in women worldwide is as high as 64.4%. Statistics from the Ministry of Health of China on the anemia status of women of childbearing age show that nearly half of women of childbearing age are anemic, of which 64.5% are anemic in pregnant women and 61.3% are anemic in breastfeeding women.

[0005] The most common type of anemia is iron deficiency anemia. Iron is the raw material for making hemoglobin. If the iron intake in the diet is insufficient, the body itself has problems absorbing iron, or blood loss may cause iron deficiency anemia. According to a survey report by the World Health Organization (WHO), about 10-30% of the world's population has varying degrees of iron deficiency. The incidence rate in men is about 10%, and the incidence rate in women is greater than 20%. The incidence rate in Asia is higher than in Europe. Women's menstruation, the dual demand for blood-forming substances by themselves and the fetus during pregnancy, and bleeding during childbirth are all direct causes of the high incidence of anemia in women.

[0006] Women with iron deficiency anemia often suffer from sub-health conditions such as chills, irregular menstruation, low immunity and fatigue, which makes women with iron deficiency anemia have multiple needs for blood supplementation and improvement of other sub-health conditions.

[0007] Commonly used iron supplements for blood supplements include ferrous lactate, ferrous sulfate, ferrous gluconate, ferrous citrate, complex iron and porphyrin iron. These iron supplements can replenish blood but cannot meet women's needs for improving other sub-health conditions.

[0008] As a relatively traditional industry, candy also needs constant innovation to meet the increasing needs of consumers for health and fashion. Candy is a common food in life, with a wide variety of varieties and different flavors, but most of the ingredients are relatively simple and lack the effect of warming the yang and strengthening the body, improving women's sub-health conditions such as anemia, irregular menstruation, low immunity, and fatigue during the menstrual period.

[0009] The main goal of the present invention is to develop a new type of compressed candy that overcomes the above disadvantages, has the function of enhancing the warming yang and strengthening the foundation, and improves sub-health conditions such as anemia, irregular menstruation, low immunity, and fatigue in women during their physiological period. Summary of the invention

[0010] The first purpose of the present invention is to provide a nutritional supplement that has the functions of enhancing the warming yang and strengthening the body, and improving sub-health conditions such as anemia, irregular menstruation, low immunity, and fatigue in women during their physiological period.

[0011] To achieve the above objectives, the embodiments of the present invention adopt the following technical solutions:

[0012] Provided is a nutritional supplement comprising high-content curcumin, iron porphyrin, turmeric, ginger powder and lactitol.

[0013] Furthermore, the nutritional supplement also includes composite probiotic powder in an equal weight ratio.

[0014] Furthermore, the nutritional supplement comprises, by weight, 5-9 parts of high-content curcumin, 90-120 parts of iron porphyrin, 30-70 parts of turmeric, 900-1200 parts of ginger powder, 800-1000 parts of lactitol, and 30-70 parts of composite probiotic powder in equal weight ratio.

[0015] Furthermore, the nutritional supplement comprises, by weight, 7 parts of high-content curcumin, 105 parts of iron porphyrin, 50 parts of turmeric, 1050 parts of ginger powder, 900 parts of lactitol, and 50 parts of composite probiotic powder in an equal weight ratio.

[0016] Furthermore, the equal weight ratio composite probiotic powder of the nutritional supplement is enteric-coated microparticles of mixed bacterial powders of equal weight ratios of Lactobacillus plantarum Lp90, Bifidobacterium longum BL21, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactis, Bifidobacterium adolescentis, and Bifidobacterium bifidum.

[0017] In order to improve the survival rate of probiotics in the intestine and enhance the function of the product, the present invention adopts composite probiotic enteric-coated microparticles.

[0018] The enteric-coated microparticles are obtained by the following steps: resuspending the composite probiotic powder in a physiological saline solution at an equal weight ratio so that the bacterial suspension is 10 10CFU / mL, prepare a mixed solution containing 2%-3% sodium alginate, 1%-2% konjac gum and 0.3%-0.7% CaCl2, and swell for 18-30h; After the bacterial suspension and the prepared mixed solution are mixed uniformly according to a volume ratio of 1: (4-6), they are added into the vegetable oil containing 0.8%-1.2% PEG-100 stearate, and after mechanical stirring to form water-in-oil droplets, they are washed with 0.8%-1.2% polyoxyethylene sorbitan monooleate aqueous solution, and then placed in a vacuum freeze dryer, dried for 36-72 hours, to obtain freeze-dried primary microcapsules; The freeze-dried primary microcapsules are placed in 2%-3% sodium alginate, 0.8%-1.2% guar gum solution, mixed uniformly, and then the mixed solution is sprayed with 1.8%-2.2% CaCO3, 0.01%-0.03% tetrazol with high pressure. The mixture is placed in a vacuum freeze dryer and dried for 36-72 hours to obtain freeze-dried secondary microcapsules; 28-32 parts of glyceryl monostearate are weighed, heated, melted and dispersed in 500-700 parts of water, 110-130 parts of triethyl citrate are added, sheared and stirred to make the dispersion uniform, and the prepared liquid is weighed, 1800-2200 parts of Eudragit L30D-55 aqueous dispersion is stirred and mixed with the prepared liquid to be uniform, and the prepared liquid is used as the enteric coating liquid, and a fluidized bed bottom spray coating device is used, 600-1000 parts of freeze-dried secondary microcapsules are used as the coating base material, and the inlet air temperature is 33-37°C, the material temperature is 23-27°C, and the outlet air temperature is 20-30°C for coating to prepare enteric microparticles.

[0019] Preferably, the composite probiotic powder is resuspended in physiological saline at an equal weight ratio to make the bacterial suspension 10 10CFU / mL, prepare a mixed solution containing 2.5% sodium alginate, 1.5% konjac gum and 0.5% CaCl2, and swell for 24h; after the bacterial suspension and the prepared mixed solution are mixed evenly at a volume ratio of 1:5, add it to the vegetable oil containing 1.0% PEG-100 stearate, mechanically stir to form water-in-oil droplets, wash it with 1.0% polyoxyethylene sorbitan monooleate aqueous solution, then place it in a vacuum freeze dryer, dry it for 54 hours, and obtain freeze-dried primary microcapsules; place the freeze-dried primary microcapsules in 2.5% sodium alginate and 1.0% guar gum solution, mix evenly, and then spray the mixed solution with 2.0% CaCO3, 0.02% tantalum at high pressure. The mixture was placed in a vacuum freeze dryer and dried for 54 hours to obtain freeze-dried secondary microcapsules; 30 parts of glyceryl monostearate were weighed, heated and melted, dispersed in 600 parts of water, 120 parts of triethyl citrate were added, sheared and stirred to make the dispersion uniform, and the prepared liquid was weighed and 2000 parts of Eudragit L30D-55 aqueous dispersion were stirred and mixed with the prepared liquid to obtain an enteric coating liquid, and a fluidized bed bottom spray coating device was used, with freeze-dried secondary microcapsules as the coating base material, and the inlet air temperature was 35°C, the material temperature was 25°C, and the outlet air temperature was 25°C for coating to prepare enteric microparticles.

[0020] In order to improve the utilization rate of active ingredients in the product, enhance product functions and facilitate taking and storage, the second purpose of the present invention is to provide a nutritional supplement tablet and a preparation method thereof.

[0021] The nutritional supplement tablet is obtained by uniformly mixing compound probiotic enteric-coated microparticles, high-content curcumin, iron porphyrin, turmeric, lactitol, ginger powder, sorbitol, D-mannitol and magnesium stearate and then pressing the mixture into tablets.

[0022] The third object of the present invention also includes providing a nutritional supplement or nutritional supplement tablet for use in the preparation of health food or special medical food.

[0023] The beneficial effects of the embodiments of the present invention are that the function of warming yang and consolidating the foundation is enhanced, and sub-health conditions such as anemia, irregular menstruation, low immunity and fatigue in women during the physiological period are improved. DETAILED DESCRIPTION

[0024] The embodiments of the present invention will be described in detail below in conjunction with the examples, but it will be appreciated by those skilled in the art that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention. If specific conditions are not specified in the examples, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0025] Example 1

[0026] High content of curcumin: 7g, iron porphyrin: 105g, turmeric: 50g, ginger powder: 1050g, lactitol: 900g.

[0027] The above components, 20 g of magnesium stearate, 3000 g of sorbitol and D-mannitol (total 10000 g) are mixed evenly and compressed into tablets.

[0028] Example 2

[0029] High-content curcumin is 9g, iron porphyrin is 120g, turmeric is 70g, ginger powder is 900g, lactitol is 1000g, and composite probiotic powder is 30g in equal weight ratio.

[0030] Resuspend 500 g of composite probiotic powder in saline to make the suspension 10 10 CFU / mL, prepare a mixed solution containing 2% sodium alginate, 2% konjac gum and 0.3% CaCl2, and swell for 30h; after the bacterial suspension and the prepared mixed solution are mixed evenly in a volume ratio of 1:4, add it to the vegetable oil containing 1.2% PEG-100 stearate, mechanically stir to form water-in-oil droplets, wash it with 0.8% polyoxyethylene sorbitan monooleate aqueous solution, then place it in a vacuum freeze dryer, dry it for 72 hours, and obtain freeze-dried primary microcapsules; the freeze-dried primary microcapsules are placed in 3% sodium alginate and 0.8% guar gum solution, mix evenly, then the mixed solution is sprayed into 2.2% CaCO3 and 0.01% Tween-80 mixed solution with high pressure, then placed in a vacuum freeze dryer, dry it for 72 hours, and obtain freeze-dried secondary microcapsules; weigh 32g of glyceryl monostearate, heat and melt and disperse it into 500m 1. Add 110g of triethyl citrate into water, shear and stir to make it dispersed evenly, and then weigh 2200g of Eudragit L30D-55 aqueous dispersion and stir and mix it evenly with the prepared liquid as enteric coating liquid. Use fluidized bed bottom spray coating device, freeze-dried secondary microcapsules as coating base material, and coat at an inlet temperature of 37°C, a material temperature of 23°C, and an outlet temperature of 30°C to prepare enteric microparticles. Take 6% enteric microparticles for this example.

[0031] A total of 10,000 g of high-content curcumin, iron porphyrin, turmeric, compound probiotic enteric-coated microparticles, lactitol, ginger powder, 20 g of magnesium stearate, 3,000 g of sorbitol, and D-mannitol are mixed evenly and pressed into tablets.

[0032] Example 3

[0033] 5g high-content curcumin, 90g iron porphyrin, 30g turmeric, 1200g ginger powder, 800g lactitol, 70g composite probiotic powder of equal weight ratio.

[0034] Resuspend the composite probiotic powder in physiological saline at an equal weight ratio to make the bacterial suspension 10 10 CFU / mL, prepare a mixed solution containing 3% sodium alginate, 1% konjac gum and 0.7% CaCl2, and swell for 18h; after the bacterial suspension and the prepared mixed solution are mixed evenly in a volume ratio of 1:6, add it to the vegetable oil containing 0.8% PEG-100 stearate, mechanically stir to form oil-in-water droplets, wash it with 1.2% polyoxyethylene sorbitan monooleate aqueous solution, then place it in a vacuum freeze dryer, dry it for 36 hours, and obtain freeze-dried primary microcapsules; The freeze-dried primary microcapsules are placed in 2% sodium alginate and 1.2% guar gum solution, mixed evenly, and then the mixed solution is sprayed into a 1.8% CaCO3 and 0.03% Tween-80 mixed solution with high pressure, and then placed in a vacuum freeze dryer, dried for 36 hours, to obtain freeze-dried secondary microcapsules; Weigh 32g of glyceryl monostearate, heat and melt and disperse it into 500m 1. Add 130g of triethyl citrate into water, shear and stir to make it dispersed evenly, and then weigh 1800g of Eudragit L30D-55 aqueous dispersion and stir and mix it evenly with the prepared liquid to use as enteric coating liquid. Use fluidized bed bottom spray coating device, freeze-dried secondary microcapsules as coating base material, and coat at an inlet air temperature of 33°C, a material temperature of 27°C, and an outlet air temperature of 20°C to prepare enteric microparticles. Take 10% of the enteric microparticles for this example.

[0035] A total of 10,000 g of high-content curcumin, iron porphyrin, turmeric, compound probiotic enteric-coated microparticles, lactitol, ginger powder, 20 g of magnesium stearate, 3,000 g of sorbitol, and D-mannitol are mixed evenly and pressed into tablets.

[0036] Example 4

[0037] High content curcumin is 7g, iron porphyrin is 105g, turmeric is 50g, ginger powder is 1050g, lactitol is 900g, and composite probiotic powder is 50g in equal weight ratio.

[0038] Resuspend 600 g of composite probiotic powder in saline to make the suspension 10 10CFU / mL, prepare a mixed solution containing 2.5% sodium alginate, 1.5% konjac gum and 0.5% CaCl2, and swell for 24h; after the bacterial suspension and the prepared mixed solution are mixed evenly in a volume ratio of 1:5, add it to the vegetable oil containing 1.0% PEG-100 stearate, after mechanical stirring to form water-in-oil droplets, wash it with 1.0% polyoxyethylene sorbitan monooleate aqueous solution, then place it in a vacuum freeze dryer, dry it for 54 hours, and obtain freeze-dried primary microcapsules; The freeze-dried primary microcapsules are placed in 2.5% sodium alginate and 1.0% guar gum solution, mix evenly, and then the mixed solution is sprayed into a 2.0% CaCO3 and 0.02% Tween-80 mixed solution with high pressure, and then placed in a vacuum freeze dryer, dry it for 54 hours, and obtain freeze-dried secondary microcapsules; Weigh 30g of glyceryl monostearate, heat and melt and disperse it into 600m 1. Add 120g of triethyl citrate to 1l of water, shear and stir to make it dispersed evenly, and then weigh 2000g of Eudragit L30D-55 aqueous dispersion and stir and mix it evenly with the prepared liquid to use as enteric coating liquid. Use fluidized bed bottom spray coating device, freeze-dried secondary microcapsules as coating base material, and coat at an inlet air temperature of 35°C, a material temperature of 25°C, and an outlet air temperature of 25°C to prepare enteric microparticles. Take 1 / 12 of the enteric microparticles for this example.

[0039] A total of 10,000 g of high-content curcumin, iron porphyrin, turmeric, compound probiotic enteric-coated microparticles, lactitol, ginger powder, 20 g of magnesium stearate, 3,000 g of sorbitol, and D-mannitol are mixed evenly and pressed into tablets.

[0040] Comparative Example 1

[0041] The method is the same as that in Example 1 except that iron porphyrin is absent.

[0042] Comparative Example 2

[0043] Without high content of curcumin, the rest is the same as Example 1.

[0044] Comparative Example 3

[0045] Without turmeric, the rest is the same as Example 1.

[0046] Comparative Example 4

[0047] Without ginger powder, the rest is the same as Example 1.

[0048] Comparative Example 5

[0049] The composite probiotics were not embedded, and the rest were the same as in Example 4.

[0050] Comparative Example 6

[0051] The freeze-dried first-level microcapsules were not prepared into freeze-dried second-level microcapsules, but were directly tableted. The rest was the same as in Example 4.

[0052] Comparative Example 7

[0053] The freeze-dried secondary microcapsules were not prepared into enteric-coated microparticles but were directly tableted. The rest was the same as in Example 4.

[0054] Comparative Example 8

[0055] The method is the same as that of Example 4 except that there is no iron porphyrin.

[0056] Comparative Example 9

[0057] Without high content of curcumin, the rest is the same as Example 4.

[0058] Comparative Example 10

[0059] Without turmeric, the rest is the same as Example 4.

[0060] Comparative Example 11

[0061] Without ginger powder, the rest is the same as Example 4.

[0062] Comparative Example 12

[0063] The freeze-dried first-level microcapsules were not prepared into freeze-dried second-level microcapsules, but were directly prepared into enteric-coated microparticles. The rest was the same as in Example 4.

[0064] 1. Animal Experiments

[0065] 1. Improve iron deficiency anemia

[0066] 1.1 Modeling and intervention

[0067] Wi star female rats were fed normally, and after one week of adaptive feeding, the body weights of the rats were weighed and recorded. The rats were randomly divided into a normal control group, a model control group, Example 1-4 groups, and Comparative Example 1-12 groups, with 10 rats in each group.

[0068] The rats in the normal control group were fed with ordinary feed, and the rats in the model control group, the embodiment group, and the comparative group were fed with low-iron feed, supplemented with a small amount of tail vein bleeding to make an iron deficiency anemia model. During the modeling period, the rats all drank deionized water, were fed for 3 weeks, and the day and night light was changed according to the natural rhythm, and the physical signs and behaviors of the rats were observed. The low-iron feed was prepared according to the feed formula recommended by AOAC, with a specific formula of 54% corn starch, 40% skim milk powder, 1% salt, and 5% golden dragon fish cooking oil. The feed was made into a rod-shaped feed strip with a diameter of 5 mm and dried for use.

[0069] The embodiment group and the comparative example group were respectively given the same amount of starch by gavage, with reference to the daily adult dosage of 32 g, and the dosage for rats was calculated according to the standard animal equivalent dose conversion coefficient method. The normal control group and the model control group were given the same amount of starch by gavage.

[0070] 1.2 Detection indicators

[0071] On the 20th day of intragastric intervention, 0.2 mL of blood was collected from the eye sockets of centrifuge tubes, and the whole blood was placed in centrifuge tubes coated with heparin. After blood collection, the tubes were shaken slowly to mix the blood and the heparin coated on the tube wall. The blood indexes were measured using a fully automatic blood analyzer, and the red blood cell (RBC) count, hemoglobin (HGB) concentration and hematocrit (HCT) were measured. The improvement of iron deficiency anemia in mice in each group is shown in Table 1.

[0072] Table 1

[0073]

[0074]

[0075] 2. Impact on immunity

[0076] 2.1 Experimental animals: SPF female Kunming mice, weighing 18 g to 22 g.

[0077] 2.2 Experimental Grouping: ConA-induced mouse lymphocyte transformation experiment and NK cell activity determination were divided into a control group, Example 1-4 groups, and Comparative Example 1-12 groups, with 10 mice in each group. The dosage of Example 1-4 groups and Comparative Example 1-12 groups was calculated according to the standard animal equivalent dose conversion coefficient method (based on 32g per day for adults), and was taken twice a day for a total of 30 days. The control group took the same amount of starch.

[0078] 2.3ConA-induced mouse lymphocyte transformation experiment (MTT method)

[0079] The spleen was removed aseptically and placed in a small dish containing an appropriate amount of sterile Hank's solution to prepare a cell suspension, which was then filtered through a 200-mesh sieve. The cells were washed twice with Hank's solution and centrifuged for 10 minutes each time (1000 r / min). The cells were then suspended in 1 mL of complete culture medium, the number of live cells was counted, and the cell concentration was adjusted to 3 × 10 with RPM I 1640 culture medium. 6 / mL. Then the cell suspension was added to two wells of a 24-well culture plate, 1mL per well, and 75μL of ConA solution (equivalent to 7.5μg / mL) was added to one well, and the other well was used as a control, and 5% carbon dioxide was placed at 37°C for 72h. 4h before the end of the culture, 0.7mL of supernatant was gently aspirated from each well, 0.7mL of RPMI 1640 culture solution without calf serum was added, and 50μL / well of MTT (5mg / mL) was added, and the culture was continued for 4h. After the culture was completed, 1mL of acidic isopropanol was added to each well, and the purple crystals were completely dissolved. Then it was dispensed into a 96-well culture plate, and 3 parallel wells were made in each well. The optical density value at a wavelength of 570nm was measured using an enzyme reader. The proliferation ability of lymphocytes was expressed by subtracting the optical density value of the well with ConA from the optical density value of the well without ConA. The effects on the transformation ability of lymphocytes in each group of mice are shown in Table 2.

[0080] Table 2

[0081]

[0082]

[0083] 2.4 Determination of NK cell activity (lactate dehydrogenase assay)

[0084] The mice were killed by cervical dislocation, and the spleens were removed aseptically to prepare spleen cell suspension. The cells were washed twice with Hank's solution, centrifuged for 10 min each time (1000 r / min), the supernatant was discarded, the cell slurry was flicked, 0.5 mL of sterile water was added for 20 seconds to lyse the red blood cells, and then 0.5 mL of 2x Hank's solution and 8 mL of Hank's solution were added. The cells were centrifuged at 1000 rpm for 10 min, and resuspended with 1 mL of RPMI 1640 complete culture medium containing 10% calf serum. The cells were stained with trypan blue and counted (the number of viable cells should be above 95%). The cell concentration was adjusted to 2×10 7 10 cells / mL as effector cells, and YAC-1 cells that grew well 24 hours after passage were taken and the cell concentration was adjusted to 4×10 5 / mL as target cells; take 100μL of target cells and effector cells (effector:target ratio 50:1) and add them to M-type 96-well culture plates; add 100μL of target cells and culture medium to the target cell natural release well, and add 100μL of target cells and 2.5% Triton to the target cell maximum release well; set three parallel wells for each of the above items, culture in a 37°C, 5% carbon dioxide incubator for 4h, then centrifuge the 96-well culture plate at 1500r / min for 5min, aspirate 100μL of supernatant from each well and place it in a flat-bottom 96-well culture plate, add 100μL / well of LDH matrix solution, react at room temperature for 3-10min, add 30μL of 1mol / L HCl to each well, and measure the optical density (OD) at a wavelength of 490nm on an enzyme reader.

[0085] NK cell activity = [(OD value of reaction well - OD value of natural release well) / (OD value of maximum release well - OD value of natural release well)] × 100%.

[0086] The effects on NK cell activity of mice in each group are shown in Table 3.

[0087] Table 3

[0088]

[0089]

[0090] 3. Effects on rats with cold stagnation and qi stagnation syndrome

[0091] 3.1 Methods

[0092] Rats were randomly divided into groups, 10 in each group, half male and half female, respectively, a normal control group, a model control group, Example 1-4 groups, and Comparative Examples 1-12 groups. Except for the normal control group, the other groups were modeled by cold stimulation method, and the rats were soaked in 0°C ice water for 20min, the water depth was 5cm, and 20mL / kg of ice water was immediately gavaged after soaking, twice a day, for 7 consecutive days. After the modeling was completed, the daily gavage dosage of Example 1-4 groups and Comparative Examples 1-12 groups was calculated according to the standard animal equivalent dose conversion coefficient method (based on 32g per day for adults). The normal control group and the model group were given equal amounts of starch, and a normal diet was given during the period for 10 consecutive days. The improvement of cold stagnation and qi stagnation syndrome in each group of mice is shown in Table 2.

[0093] 3.2 Determination of cAMP and cGMP content in rat serum

[0094] Serum samples were taken and the cAMP and cGMP levels in the serum of rats in each group were determined by Elisa method. The specific operations were carried out according to the instructions of the corresponding kits. The results are shown in Table 4.

[0095] 3.3 Results

[0096] Table 4

[0097]

[0098]

[0099] The links not described in detail in the present invention are all common knowledge that can be selected by ordinary technicians in the field. Although the present invention has been described in detail above with general descriptions and specific implementation schemes, it is obvious to ordinary technicians in the field that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A nutritional supplement, It is characterized in that The invention is prepared from 5-9 parts of high-content curcumin, 90-120 parts of iron porphyrin, 30-70 parts of turmeric, 900-1200 parts of ginger powder, 800-1000 parts of lactitol and enteric-coated microparticles by weight. The enteric-coated microparticles are obtained by the following steps: resuspending the composite probiotic powder in physiological saline to make the bacterial suspension 10 10 CFU / mL, prepared with 2%-3% sodium alginate, 1%-2% konjac gum and 0.3%-0.7% CaCl 2 The mixed solution is swollen for 18-30 hours; the bacterial suspension and the prepared mixed solution are mixed evenly in a volume ratio of 1:(4-6), and then added to a vegetable oil containing 0.8%-1.2% PEG-100 stearate, mechanically stirred to form water-in-oil droplets, washed with a 0.8%-1.2% polyoxyethylene sorbitan monooleate aqueous solution, and then placed in a vacuum freeze dryer for 36-72 hours to obtain freeze-dried primary microcapsules; the freeze-dried primary microcapsules are placed in a 2%-3% sodium alginate and 0.8%-1.2% guar gum solution, mixed evenly, and then the mixed solution is sprayed into a 1.8%-2.2% CaCO 3 , 0.01%-0.03% Tween-80 mixed solution, and then placed in a vacuum freeze dryer, dried for 36-72 hours to obtain freeze-dried secondary microcapsules; weigh 28-32 parts of glyceryl monostearate, heat and melt, disperse in 500-700 parts of water, add 110-130 parts of triethyl citrate, shear and stir to disperse evenly, to obtain a prepared liquid, then weigh 1800-2200 parts of Eudragit L30D-55 aqueous dispersion and stir and mix evenly with the prepared liquid, as an enteric coating liquid, adopt fluidized bed The bottom bed spray coating device uses 700-800 portions of freeze-dried secondary microcapsules as coating base materials, and performs coating at an inlet air temperature of 33-37°C, a material temperature of 23-27°C, and an outlet air temperature of 20-30°C to prepare enteric microparticles; the composite probiotic powder is a mixed powder of Lactobacillus plantarum Lp90, Bifidobacterium longum BL21, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactis, Bifidobacterium adolescentis, and Bifidobacterium bifidum in equal weight ratios, and the composite probiotic powder accounts for 30-70 portions in the nutritional supplement.

2. The nutritional supplement according to claim 1, It is characterized in that In terms of weight, the high-content curcumin is 7 parts, the iron porphyrin is 105 parts, the turmeric is 50 parts, the ginger powder is 1050 parts, the lactitol is 900 parts, and the composite probiotic powder is 50 parts.

3. The nutritional supplement according to claim 1, It is characterized in that The nutritional supplement is in the form of tablets.

4. The nutritional supplement according to claim 3, It is characterized in that The tablet is obtained by uniformly mixing enteric-coated microparticles, high-content curcumin, iron porphyrin, turmeric, lactitol, ginger powder, sorbitol, D-mannitol and magnesium stearate and then tabletting.

5. Use of the nutritional supplement according to any one of claims 1 to 4 in the preparation of health food or special medical food.

Images