A high-protein nutritional composition containing medium-chain triglycerides and uses thereof

Abstract

The present application relates to the technical field of nutritional combination, in particular to a kind of high-protein nutritional powder composition containing medium-chain triglyceride and application thereof.The composition contains the following components mixedly stored or stored independently: carbohydrate, fat, protein, dietary fiber, mineral, vitamin and component A, wherein the weight parts of each component are as follows: fat 15-60 parts, protein 20-90 parts, dietary fiber 10-30 parts, mineral 0.5-30 parts, vitamin 0.02-3 parts, and component A 1-15 parts;the component A is selected from any one or combination of the following extracts: yam, poria cocos, lily, tremella fuciformis, polygonatum, dandelion, medlar, jujube and blueberry.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of nutritional composition, in particular to a high-protein nutritional composition containing medium-chain triglycerides and application thereof. BACKGROUND

[0002] Tuberculosis (TB) is an infectious disease and one of the leading causes of death worldwide. It is also the leading cause of death from a single infectious agent. Malnutrition is extremely common in TB patients, especially poverty-related malnutrition is one of the high-risk factors for the onset of TB. The nutritional status of patients is not only directly related to the onset and progression of TB, but also has a direct impact on the choice of TB treatment regimen and efficacy. Therefore, the malnutrition status of TB patients should be actively corrected.

[0003] The incidence of nutritional risk in TB patients is relatively high, generally above 35%, and the highest can reach 86.1%. Moreover, the physiological function, physiological function, body pain, fatigue and general health status of patients with nutritional risk are worse than those of patients without nutritional risk. The main manifestations of nutrient deficiency in TB patients are: prone to protein and energy supply deficiency, abnormal protein and amino acid metabolism, abnormal blood lipids, low cholesterol is common, vitamin A, vitamin B6 and vitamin C are generally deficient, more than 50% of patients have vitamin D deficiency, and serum zinc, selenium and iron concentrations are generally low. In the research of Wu Xiaoguang et al., 62 cases of pulmonary tuberculosis patients were evaluated by NRS2002, and randomly divided into enteral nutrition group and parenteral nutrition group. The results showed that the ideal body mass percentage, serum albumin, hemoglobin and total lymphocyte count of the two groups after treatment were significantly different from those before treatment; the ideal body mass percentage and T lymphocytes of the enteral nutrition group were significantly improved compared with the parenteral nutrition group, and the NRS2002 evaluation results showed that the nutritional status of the two groups was improved, and the nutritional status of the enteral nutrition group was significantly better than that of the parenteral nutrition group.

[0004] It can be seen that the proportion of TB patients with nutritional risk is relatively high. For TB patients with nutritional risk, a five-step nutrition treatment mode should be implemented, in which enteral nutrition support is the preferred nutritional support method and nutritional treatment means in clinical practice.

[0005] Among them, oral administration is the most ideal enteral nutrition support administration route, which is most consistent with the physiological characteristics, and is easily accepted by patients with good compliance. Moreover, oral nutritional supplementation can significantly improve the nutritional status of patients, such as increasing the levels of hemoglobin, transferrin, albumin and prealbumin in malnourished patients. However, for pulmonary tuberculosis patients, the respiratory quotient of fat is relatively low, and appropriate increase in the energy supply ratio of fat can protect lung function, but the increase of fat will increase the burden of liver and gastrointestinal tract, and the tuberculosis drugs themselves also have a certain damage to liver function.

[0006] Therefore, it is of great significance for the tuberculosis patients to develop a nutritional product which can improve the fat energy supply ratio without increasing the burden of liver and gastrointestinal tract. SUMMARY

[0007] The present application aims to provide a high-protein nutritional product containing medium-chain triglycerides which can improve the fat energy supply ratio without increasing the burden of liver and gastrointestinal tract, can effectively improve the nutritional status of tuberculosis patients with nutritional risk, and is of great significance for the tuberculosis patients.

[0008] To achieve the above object, the technical scheme adopted by the present application is as follows.

[0009] In a first aspect, the present application provides a high-protein nutritional composition containing medium-chain triglycerides.

[0010] The composition contains the following components mixed or stored independently: carbohydrates, fats, proteins, dietary fibers, minerals, vitamins and component A; the weight parts of each component are as follows: 15-60 parts of fat, 20-90 parts of protein, 10-30 parts of dietary fiber, 0.5-30 parts of mineral, 0.02-3 parts of vitamin, and 1-15 parts of component A.

[0011] The fat contains medium-chain triglycerides; the content of medium-chain triglycerides accounts for 30-50 wt% of the total weight of the fat.

[0012] The component A is selected from any one or combination of the following extracts: yam, poria cocos, lily, tremella fuciformis, polygonatum, dandelion, medlar, jujube and blueberry; the above components can provide homologous medicinal and food components or phytochemicals for the tuberculosis patients, make up for the lack of such nutritional components in ordinary nutritional preparations, and have the effects of tonifying the spleen, moistening the lungs and improving immunity.

[0013] In a specific embodiment, the fat further contains at least one of n-3 polyunsaturated fatty acids, vegetable oil and animal oil.

[0014] In a specific embodiment, the vegetable oil is selected from at least one of the following: corn oil, rapeseed oil, soybean oil, peanut oil, coconut oil, tea oil, safflower oil and olive oil; and the animal oil is selected from at least one of the following: milk fat, fish oil microcapsule powder and flaxseed oil microcapsule powder.

[0015] Linseed oil is a plant oil containing a variety of unsaturated fatty acids, such as alpha-linolenic acid, linoleic acid, oleic acid, etc., among which the content of alpha-linolenic acid can reach up to 53%, which is unmatched by other plant oils. Because of the sensitivity of unsaturated fatty acids to oxygen and their own unique odor, linseed oil microcapsule powder can effectively prevent the oxidation of unsaturated fatty acids and mask their unpleasant odor. Linolenic acid and its metabolites DHA, DPA, EPA, etc. have immune regulation, anti-inflammatory support, etc. Among them, n-3 series fatty acids can inhibit the release of local lung tissue inflammatory mediators, reduce the adverse reactions caused by inflammatory mediators, such as pulmonary hypertension, alveolar membrane high permeability, pulmonary edema, etc., protect alveolar epithelial cells, avoid the aggravation of lung lesions, and improve the clinical symptoms of patients to expand blood vessels and promote blood circulation.

[0016] In a specific embodiment, the carbohydrate is selected from at least one of maltodextrin, corn flour, oat flour, wheat flour, and enzymatically treated rice flour.

[0017] In a specific embodiment, the protein is selected from at least one of soy protein, soy protein isolate, hydrolyzed soy protein peptide, concentrated whey protein, isolated whey protein, and hydrolyzed whey protein peptide.

[0018] In a specific embodiment, the dietary fiber is selected from at least one of fructooligosaccharide, isomaltooligosaccharide, inulin, xylooligosaccharide, and resistant dextrin.

[0019] In a specific embodiment, the mineral is selected from at least one of iron, calcium, zinc, selenium, magnesium, potassium, copper, manganese, phosphorus, and iodine; and the vitamin is selected from at least one of vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, vitamin B6, vitamin B 12 , niacin, folic acid, pantothenic acid, vitamin C, and biotin.

[0020] Preferably, the high-protein nutritional composition containing medium-chain triglycerides comprises two or more of the following components mixed or independently stored: carbohydrate, fat, protein, dietary fiber, mineral, vitamin, and component A.

[0021] The weight parts of each component are as follows: fat 15-60 parts, protein 20-90 parts, dietary fiber 10-30 parts, mineral 0.5-30 parts, vitamin 0.02-3 parts, and component A 1-15 parts.

[0022] The component A is a combination of yam and lily with a weight ratio of 1:1-3.

[0023] The fat is medium-chain triglyceride, vegetable fat and animal fat, and the content of the medium-chain triglyceride is 30-50 wt%, the content of the vegetable fat is 35-60 wt%, and the content of the animal fat is 10-15 wt% based on the total mass of the fat;

[0024] The protein is at least one selected from the group consisting of soybean protein isolate, concentrated whey protein, and hydrolyzed whey protein peptide; the dietary fiber is a combination of inulin and resistant dextrin at a weight ratio of 1:1-3; the mineral is at least one selected from the group consisting of iron, calcium, zinc, and magnesium; and the vitamin is at least one selected from the group consisting of vitamin A, vitamin E, vitamin B1, vitamin B2, vitamin B 12

[0025] In one preferred embodiment of the present application, the medium-chain triglyceride-containing high-protein nutritional composition comprises a main material and an auxiliary material, the main material contains carbohydrates, fat, protein, dietary fiber, mineral, vitamin, and component A, and the auxiliary material contains xylitol, xanthan gum, and silicon dioxide.

[0026] In the auxiliary material, the content of the fat is 15-60 parts by weight, the content of the protein is 20-90 parts by weight, the content of the dietary fiber is 10-30 parts by weight, the content of the mineral is 0.5-30 parts by weight, the content of the vitamin is 0.02-3 parts by weight, and the content of the component A is 1-15 parts by weight, relative to 100 parts by weight of the carbohydrates;

[0027] The fat is medium-chain triglyceride, vegetable fat and animal fat, and the content of the medium-chain triglyceride is 30-50 wt%, the content of the vegetable fat is 35-60 wt%, and the content of the animal fat is 10-15 wt% based on the total mass of the fat;

[0028] The vegetable fat is a combination of rapeseed oil, soybean oil, and coconut oil at a weight ratio of 1:1-3:1-3;

[0029] The protein is at least one selected from the group consisting of soybean protein isolate, concentrated whey protein, and hydrolyzed whey protein peptide;

[0030] The dietary fiber is a combination of inulin and resistant dextrin at a weight ratio of 1:1-3;

[0031] The mineral is at least one selected from the group consisting of iron, calcium, zinc, and magnesium;

[0032] ​In the mineral, the content of iron is 3-40 mg / 100 g, the content of calcium is 200-1600 mg / 100 g, the content of zinc is 2-25 mg / 100 g, and the content of magnesium is 70-280 mg / 100 g, based on 100 g of the nutritional powder;

[0033] The vitamin is at least one selected from vitamin A, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin C, nicotinic acid, folic acid, and pantothenic acid;

[0034] In the vitamin, the content of vitamin A is 150-1700 μg RE / 100 g, the content of vitamin E is 3-100 mg a-TE / 100 g, the content of vitamin B1 is 0.25-3.5 mg / 100 g, the content of vitamin B2 is 0.25-3.5 mg / 100 g, the content of vitamin B6 is 0.25-3.5 mg / 100 g, the content of vitamin C is 20-600 mg / 100 g, the content of nicotinic acid is 0.8-35 mg / 100 g, the content of folic acid is 80-850 μg / 100 g, and the content of pantothenic acid is 1-25 mg / 100 g, based on 100 g of the protein nutritional powder;

[0035] The A component is a combination of yam and lily with a content weight ratio of 1:1-3;

[0036] The content of the xylitol is 5-10 parts by weight, the content of the xanthan gum is 0.2-0.5 parts by weight, and the content of the silicon dioxide is 0.5-1 parts by weight, relative to 100 parts by weight of the main material.

[0037] In another preferred specific embodiment of the present application, a high-protein nutritional composition containing medium-chain triglycerides contains the following components mixed and stored together or stored independently:

[0038] Carbohydrate, fat, protein, dietary fiber, mineral, vitamin, and A component;

[0039] In the composition, the content of the fat is 15-60 parts by weight, the content of the protein is 20-90 parts by weight, the content of the dietary fiber is 10-30 parts by weight, the content of the mineral is 0.5-30 parts by weight, the content of the vitamin is 0.02-3 parts by weight, and the content of the A component is 1-15 parts by weight, relative to 100 parts by weight of the carbohydrate;

[0040] The fat is medium-chain triglyceride, vegetable fat and animal fat, and the content of the medium-chain triglyceride is 30-50 wt%, the content of the vegetable fat is 35-60 wt%, and the content of the animal fat is 10-15 wt% based on the total mass of the fat;

[0041] The protein is at least one selected from the group consisting of soybean protein isolate, concentrated whey protein, and hydrolyzed whey protein peptide;

[0042] The dietary fiber is a combination of inulin and resistant dextrin at a weight ratio of 1:1-3.

[0043] The mineral is at least one selected from the group consisting of iron, calcium, zinc, and magnesium;

[0044] The vitamin is at least one selected from the group consisting of vitamin A, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin C, niacin, folic acid, and pantothenic acid;

[0045] The A component is a combination of yam and lily at a weight ratio of 1:1-3.

[0046] Medium-chain triglyceride (MCT) is different from long-chain triglyceride (LCT) in digestion, absorption, transport and metabolism in the body. The speed of its digestion and metabolism in the body is equivalent to that of glucose, and the energy generated is 2 times higher than that generated by glucose. The MCT entering the body has little dependence on bile salts and pancreatic enzymes, is rapidly hydrolyzed into MCFA and glycerol by lipase in the intestinal tract, and is absorbed by the intestinal epithelial cells without forming triglycerides or chylomicrons. The MCFA does not need to pass through the lymphatic system, but is directly transported to the liver through the portal vein. The MCFA transported to the coenzyme liver cells does not need to rely on the action of carnitine transferase, but is directly introduced into the mitochondria for β-oxidation. The acetyl coenzyme A generated by MCFA can enter the tricarboxylic acid cycle in the mitochondria to be completely oxidized into carbon dioxide and water, or generate ketone bodies and extend the carbon chain of fatty acids, and can also enter the cell liquid to participate in lipid de novo synthesis. The characteristics of rapid digestion and absorption and oxidative metabolism of MCT make a large amount of acetyl CoA generated, and excessive acetyl CoA is synthesized into ketone bodies.

[0047] In a second aspect, the present application provides a method for preparing a medium-chain triglyceride-containing high-protein nutritional composition, which comprises mixing the components in the medium-chain triglyceride-containing high-protein nutritional composition.

[0048] The composition is prepared into powder, tablet, stick and the like for oral administration.

[0049] In a third aspect, the present application provides a use of a medium-chain triglyceride-containing high-protein nutritional composition in the adjuvant therapy of tuberculosis patients.

[0050] Malnutrition is an important factor affecting the treatment effect of tuberculosis patients. The incidence of nutritional risk of tuberculosis patients is generally above 35%, and the highest can reach 86.1%. According to the World Health Organization (WHO) Global Tuberculosis Report 2021, there were 9.87 million new tuberculosis patients worldwide in 2020, with an incidence of 127 / 100,000, of which an estimated 2.3 million tuberculosis cases were attributable to malnutrition. There is a complex internal relationship between tuberculosis and nutrition, and malnutrition can increase the risk of treatment failure, death and acquired drug resistance of patients, especially the development of multidrug-resistant tuberculosis (MDR-TB), which makes the control of tuberculosis epidemic situation more severe, and is one of the many factors leading to the prevalence of tuberculosis. Due to the characteristics of MDR-TB itself, the degree of malnutrition of patients is more serious, and malnutrition may further worsen the condition and lead to treatment failure.

[0051] For patients with pulmonary tuberculosis, the respiratory quotient of fat is relatively low, and appropriate increase of the energy supply ratio of fat can protect lung function, but the increase of fat will increase the burden of liver and gastrointestinal tract,

[0052] The medium-chain triglyceride-containing high-protein nutritional composition provided by the present application contains medium-chain triglycerides, which can not only increase the energy supply ratio of fat, but also will not increase the burden of liver and gastrointestinal tract; and contains protein, vitamins, trace mineral elements and other nutrients, which are balanced in nutrition, can effectively prevent and treat malnutrition, and can significantly improve the nutritional status of patients, such as increasing the levels of hemoglobin, transferrin, albumin and prealbumin in the body of malnourished patients, which is of great significance for patients with pulmonary tuberculosis.

[0053] The medium-chain triglyceride-containing high-protein nutritional composition provided by the present application contains medicinal and edible substances or plant extracts, and various beneficial ingredients and nutrients synergistically improve the gastrointestinal discomfort and immunity of tuberculosis patients, making up for the lack of medicinal and edible substances and plant chemicals in ordinary nutritional preparations.

[0054] Compared with the prior art, the beneficial effects of the present application are as follows:

[0055] In view of the special nutritional metabolism characteristics and nutritional needs of patients with pulmonary tuberculosis, a nutritional product suitable for tuberculosis patients is developed. Reasonable and appropriate nutritional support and intervention are provided for tuberculosis patients. DETAILED DESCRIPTION

[0056] In order to enable those skilled in the art to better understand the technical solutions of the present application, the following examples further describe the present application in detail, and the following examples are only used to illustrate the present application, but not to limit the scope of the present application.

[0057] In the present application, the room temperature or normal temperature means 25±2℃.

[0058] In the present application, the medium-chain triglyceride (hereinafter referred to as MCT) is a product obtained by esterification of glycerol with fatty acids having carbon chains composed of 6 to 12 carbon atoms. Exemplarily, the medium-chain triglyceride (MCT) can be caprylic acid triglyceride, capric acid triglyceride, caprylic acid-capric acid mixed triglyceride, etc.

[0059] In the present application, the n-3 polyunsaturated fatty acid represents "containing 18 to 22 carbon atoms, containing at least two double bonds in these carbon atoms, and the first double bond appears at the third position of the methyl end of the carbon chain". Exemplarily, the n-3 polyunsaturated fatty acid can be α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, etc.

[0060] The vegetable oil in the present application is selected from at least one of corn oil, rapeseed oil, soybean oil, peanut oil, coconut oil, tea oil, safflower oil, olive oil.

[0061] The content of erucic acid in the rapeseed oil in the present application accounts for ≤3wt% of the total amount of fatty acids in the rapeseed oil.

[0062] The animal fat in the present application is selected from at least one of milk fat, fish oil microcapsule powder, flaxseed oil microcapsule powder.

[0063] The carbohydrate in the present application is selected from at least one of malt dextrin, corn powder, oat powder, wheat powder, rice powder sequentially subjected to puffing and enzymatic treatment.

[0064] The protein in the present application is selected from at least one of soybean protein, soybean protein isolate, hydrolyzed soybean protein peptide, concentrated whey protein, separated whey protein, hydrolyzed whey protein peptide.

[0065] The dietary fiber in the present application is selected from at least one of fructooligosaccharide, isomaltooligosaccharide, inulin, xylooligosaccharide, resistant dextrin.

[0066] The mineral in the present application is selected from at least one of iron, calcium, zinc, selenium, magnesium, potassium, copper, manganese, phosphorus, iodine.

[0067] According to a particularly preferred specific embodiment, the vitamin is selected from at least one of vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, vitamin B6, vitamin B 12 , niacin, folic acid, pantothenic acid, vitamin C, biotin.

[0068] The method for preparing the medium-chain triglyceride-containing high-protein nutritional powder of the present application comprises mixing the components in the composition of the first aspect.

[0069] Preferably, the operation of mixing the components in the composition comprises:

[0070] (1) crushing the dietary fiber to obtain a dietary fiber powder passing through a 20-60 mesh sieve;

[0071] (2) first contact mixing the mineral, the vitamin, and the carbohydrate to obtain a first mixture;

[0072] (3) second contact mixing the first mixture, the dietary fiber powder, the fat, the protein, and the A component to obtain a second mixture, and passing the second mixture through a 20-60 mesh sieve.

[0073] Preferably, the conditions of the first contact mixing include at least: a stirring speed of 100-1500 rpm, a temperature of 20-30°C, and a time of 1-5 min.

[0074] The present application will be described in detail below by way of examples. The various raw materials in the following examples are commercially available. In the following examples, the vegetable oil and fat is a combination of rapeseed oil, soybean oil, and coconut oil in a weight ratio of 1:1:2; 1 part by weight means 1 g.

[0075] Example 1

[0076] This example is used to illustrate the preparation of the high-protein nutritional powder containing medium-chain triglycerides according to the formulation and process parameters in Table 1, and the method is as follows.

[0077] The method for preparing the high-protein nutritional powder containing MCT includes the following steps:

[0078] (1) crushing the dietary fiber to obtain a dietary fiber powder passing through a 20 mesh sieve;

[0079] (2) first contact mixing the mineral, the vitamin, and the carbohydrate to obtain a first mixture; wherein the conditions of the first contact mixing are: a stirring speed of 500 rpm, a temperature of room temperature, and a time of 3 min;

[0080] (3) second contact mixing the first mixture, the dietary fiber powder, the fat, the protein, and the A component to obtain a second mixture, and passing the second mixture through a 20 mesh rotary vibrating screen; wherein the conditions of the second contact mixing are: a stirring speed of 1500 rpm, a temperature of room temperature, and a time of 3 min.

[0081] The remaining examples use the same process as Example 1, unless otherwise specified, except that the input amount of each component in the high-protein nutritional powder containing MCT used is different, as shown in Table 1.

[0082] Table 1: Formula of high-protein nutritional powder containing medium-chain triglycerides

[0083] Item Component Nutritional powder 1 Nutritional powder 2 Nutritional powder 3 Nutritional powder 4 Main material Malt dextrin 100.0 100.0 100.0 100.0 Main material Concentrated whey protein 23.8 17.7 37.2 23.6 Main material Hydrolyzed whey protein peptide / / 12.4 4.7 Main material Soybean protein isolate 19.9 14.2 24.8 23.6 Main material Vegetable fat powder 15.9 14.2 19.8 35.4 Main material Medium-chain triglyceride 15.9 10.6 24.8 18.9 Main material Fish oil microcapsule powder 4.0 3.5 5.0 7.1 Main material Inulin 6.0 5.3 7.4 7.1 Main material Resistant dextrin 6.0 5.3 7.4 7.1 Main material Vitamin A 0.00099 0.00089 0.00124 0.00118 Main material Vitamin E 0.01986 0.01775 0.02478 0.02361 Main material Vitamin B1 0.00199 0.00177 0.00248 0.00236 Main material Vitamin B2 0.00199 0.00177 0.00248 0.00236 Main material Vitamin B6 0.00199 0.00177 0.00248 0.00236 Main material Vitamin C 0.19861 0.17746 0.24784 0.23613 Main material Niacin 0.02383 0.02130 0.02974 0.02834 Main material Folic acid 0.00030 0.00027 0.00037 0.00035 Main material Pantothenic acid 0.00596 0.00532 0.00744 0.00708 Main material Calcium 0.69514 0.62113 0.86742 0.82646 Main material Magnesium 0.29792 0.26620 0.37175 0.35420 Main material Zinc 0.01986 0.01775 0.02478 0.02361 Main material Iron 0.02383 0.02130 0.02974 0.02834 Main material Chinese yam 2.0 1.8 2.5 2.4 Main material Lily 4.0 3.5 5.0 4.7 Auxiliary material Xylitol 16 14 20 19 Auxiliary material Xanthan gum 0.8 0.7 1.0 0.9 Auxiliary material Silicon dioxide 1.6 1.4 2.0 1.9

[0084] Example 2

[0085] Physicochemical property test

[0086] The protein content, fat content, dietary fiber, moisture, ash content, and microbial indicators of the high-protein nutritional powder prepared from the nutritional powder 1 of Example 1 were tested, and the specific test results are shown in Table 2.

[0087] Among them, the protein content of the prepared nutritional powder was tested by the national standard GB 5009.5, the fat content of the prepared nutritional powder was tested by the national standard GB 5009.6, the moisture of the prepared nutritional powder was tested by the national standard GB 5009.3, and the ash content of the prepared nutritional powder was tested by the national standard GB 5009.4. The dietary fiber of the prepared nutritional powder was tested by the national standard GB 5009.88 or the specified detection method. The carbohydrate and energy of the prepared nutritional powder were calculated according to the measured protein, fat, dietary fiber, moisture, and ash. The microbial indicators of the prepared nutritional powder were tested by the method specified in the national standard GB 29922, and the specific test results are shown in Table 2.

[0088] Table 2: Physicochemical indicators of nutritional powder

[0089]

[0090] The test results show that the physicochemical indicators, nutritional component indicators, and microbial indicators of the high-protein nutritional powder prepared in the foregoing examples all meet the national standards.

[0091] Test Example 3: Human test

[0092] 191 patients with bone tuberculosis were divided into test group 1, test group 2, and control group. The control group was given conventional treatment and surgical treatment, including anti-infection, anti-tuberculosis, surgery, and other clinical treatments, and the diet was a nutritional meal provided by the canteen. The test group 1 was given the nutritional powder in Example 1 after surgery on the basis of conventional diet and surgery and treatment, 50g each time, 3 times a day, for 2 weeks of intervention. The test group 2 was given the nutritional powder in Example 2 after surgery on the basis of conventional diet and surgery and treatment, and the nutritional status of the three groups at the starting point and the endpoint was compared:

[0093] Table 3

[0094]

[0095] As can be seen from Table 3, the high-protein nutritional powder of Example 1 provided by the present application can make the postoperative albumin level of the tuberculosis patient increase faster, the CRP level decrease faster, and the hemoglobin level slightly increase at 2 weeks after the operation, while the hemoglobin levels of the other two groups show a downward trend. The nutritional powder of Example 1 can effectively improve the nutritional status and inflammatory response of the tuberculosis patient after the operation.

[0096] Test Example 4: Human test

[0097] Seventy-six patients diagnosed with pulmonary tuberculosis and having nutritional risk were included in three hospitals and randomly divided into a test group and a control group. Patients who were excluded from the test and had incomplete data were excluded, and finally 34 patients in the test group and 27 patients in the control group were obtained. The control group: on the basis of conventional treatment, Ansi was given 3 times a day, 50g each time. The test group: on the basis of conventional treatment, the nutritional powder in Example 1 was given 3 times a day, 50g each time, for 2 weeks of intervention. The nutritional status of the two groups at the starting point of the test, 1 week of intervention and the endpoint was compared.

[0098] Table 4

[0099]

[0100] As can be seen from Table 4, the high-protein nutritional powder of Example 1 provided by the present application can make the hemoglobin of the pulmonary tuberculosis patient slightly increase, while the hemoglobin of the control group continues to decrease, and the CRP level decreases more than the control group. The same as the results of Human Test 1, the nutritional powder can improve the nutritional status and inflammatory response of the pulmonary tuberculosis patient.

[0101] The preferred embodiments of the present application are described in detail above, but the present application is not limited thereto. Within the technical concept of the present application, various simple modifications can be made to the technical solutions of the present application, including the combination of various technical features in any other suitable manner. These simple modifications and combinations should also be considered as disclosed by the present application and fall within the protection scope of the present application.

Claims

1. A nutritional composition for use in the adjuvant treatment of a patient with bone tuberculosis, said nutritional composition consisting of the following parts by weight: Maltodextrin 100 parts, concentrated whey protein 23.8 parts, soy protein isolate 19.9 parts, vegetable fat powder 15.9 parts, medium-chain triglyceride 15.9 parts, fish oil microcapsule powder 4.0 parts, inulin 6.0 parts, resistant dextrin 6.0 parts, vitamin A 0.00099 parts, vitamin E 0.01986 parts, vitamin B1 0.00199 parts, vitamin B2 0.00199 parts, vitamin B6 0.00199 parts, vitamin C 0.19861 parts, nicotinic acid 0.02383 parts, folic acid 0.00030 parts, pantothenic acid 0.00596 parts, calcium 0.69514 parts, magnesium 0.29792 parts, zinc 0.01986 parts, iron 0.02383 parts, yam 2.0 parts, lily 4.0 parts, xylitol 16 parts, xanthan gum 0.8 parts, and silicon dioxide 1.6 parts.

2. The nutritional composition for adjuvant treatment of patients with bone tuberculosis as described in claim 1, characterized in that, The nutritional composition is prepared as a powder or a tablet.

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