An experimental mouse oral manipulation device

Abstract

The application discloses an experimental mouse oral cavity operating device, which comprises a first plate, a second plate, a first positioning component, a second positioning component, a third positioning component, a fourth positioning component, a fifth positioning component, a maxillary tooth fixing piece, a corner pull hook, a first elastic piece and a second elastic piece. The first plate and the second plate are foldably connected. The first positioning component, the second positioning component and the third positioning component are arranged on the first plate and are distributed in a substantially equilateral triangle shape. The maxillary tooth fixing piece is arranged on the first positioning component. The corner pull hook is connected to the second positioning component and the third positioning component through the first elastic piece. The fourth positioning component and the fifth positioning component are arranged on the second plate. The second elastic piece is connected to the fourth positioning component and the fifth positioning component. The application provides an experimental mouse oral cavity operating device which is convenient to operate and can expose the oral cavity sufficiently.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of experimental equipment, in particular to an experimental mouse oral cavity operation device. BACKGROUND

[0002] Dental caries, periodontal disease, mucosal disease, etc. are common oral diseases, and oral problems affect almost everyone. Unhealthy oral conditions will have adverse effects on diet, language, emotions, psychology, and overall health. Mice have about 90% homology with humans in terms of genes, there are many gene strains, relevant biochemical reagents are easily available, the cost of raising mice is low, and the feeding conditions are easy to achieve. Mice play an extremely important role in the study of the molecular mechanisms of oral diseases. Therefore, it is necessary to use model animals to explore the mechanisms of various oral diseases.

[0003] The present application inventors summarized the following shortcomings of the existing mouse oral cavity modeling workbench during long-term experiments:

[0004] 1. The mouse body position cannot be adjusted: when the mouse is supine on the operating table, the mandible forms a 90° angle with the horizontal plane. At the same time, due to the deep location of the mouse's lower molar, the available space in the mouth is small, so it is difficult to operate the surgery that requires mandibular modeling;

[0005] 2. Insufficient lateral exposure: the existing workbench can stably pull apart the upper and lower incisors of the mouse, opening the oral cavity from the vertical direction, but the lateral corners are not pulled apart, and the horizontal exposure is insufficient. Especially when performing mandibular oral modeling, the view and operation space of the operator are not good due to the obstruction of the tongue tissue, and stable exposure of the lateral space is more necessary;

[0006] 3. The light in the operation area is dim: the operator's operable space in the mouse oral modeling is small, and the external light source is easily blocked, resulting in dim light in the operation area;

[0007] 4. Easily induce stress and dry eye syndrome in experimental animals: the existing workbench uses external light sources, which are white light illuminating lamps. Strong light stimulation easily induces stress and dry eye syndrome in experimental animals, increasing the error factors of the experiment;

[0008] 5. Requires multiple people to operate: the existing mouse opening and skull fixation requires the help of an assistant to pull apart the corners of the mouth from the side, and to stably fix the skull, and to adjust the position according to the operation site of the operator at all times, which affects the experiment. If only one operator operates, the oral exposure is insufficient, the operation space is limited, and the operator is prone to injury and the operation time is increased. SUMMARY

[0009] The present application provides an experimental mouse oral cavity operation device that is convenient to operate and has sufficient oral cavity exposure.

[0010] To achieve this purpose, the present application provides the following technical solutions:

[0011] The application provides an experimental mouse oral cavity operating device, which comprises a first plate, a second plate, a first positioning component, a second positioning component, a third positioning component, a fourth positioning component, a fifth positioning component, a maxillary tooth fixing piece, a corner draw hook, a first elastic piece and a second elastic piece, the first plate and the second plate are foldably connected, the first positioning component, the second positioning component and the third positioning component are arranged on the first plate, and the first positioning component, the second positioning component and the third positioning component are distributed in an equilateral triangle shape, the maxillary tooth fixing piece is arranged on the first positioning component, and the corner draw hook is connected to the second positioning component and the third positioning component through the first elastic piece; the fourth positioning component and the fifth positioning component are arranged on the second plate, and the second elastic piece is connected to the fourth positioning component and the fifth positioning component.

[0012] Preferably, the first positioning component comprises a plurality of vertically distributed threaded holes and a screw rod matched with any threaded hole, and the maxillary tooth fixing piece is arranged on the screw rod.

[0013] Preferably, the second positioning component, the third positioning component, the fourth positioning component and the fifth positioning component comprise a long strip-shaped threaded groove and a screw rod.

[0014] Preferably, the corner draw hook comprises a J-shaped hook body and an LED lamp strip, the J-shaped hook body is hollow, the LED lamp strip is arranged in the J-shaped hook body, and the LED lamp strip is connected with a power supply.

[0015] Preferably, the first plate and the second plate are hingedly connected.

[0016] Preferably, the device further comprises a third plate and a support frame, the third plate is arranged on the back of the first plate, a plurality of parallel grooves are arranged on the third plate, and the two ends of the support frame are supported on the grooves and the first plate.

[0017] Preferably, the corner draw hook is made of silica gel material.

[0018] Preferably, the maxillary tooth fixing piece comprises a metal ring.

[0019] Preferably, the first elastic piece and the second elastic piece each comprise a rubber band.

[0020] Preferably, the folding inner angle of the first plate and the second plate is 95-180°.

[0021] In summary, the use method and principle of the experimental mouse oral cavity operating device are briefly summarized as follows:

[0022] When the mouse is supine on the workbench, the upper and lower jaws and the tongue of the mouse can be fixed, and the body position of the mouse can be flexibly adjusted according to the modeling needs. For example, when the platform is parallel to the ground (i.e., the platform is placed on a flat surface), the upper jaw oral cavity modeling operation of the mouse can be performed; when the platform is about 75° to the ground, the lower jaw of the mouse is parallel to the ground, and the lower jaw oral cavity modeling operation of the mouse can be performed. When using the device, the anesthetized mouse is placed in a supine position on the platform, the body position of the mouse is adjusted according to the modeling needs, the upper front teeth of the mouse are fixed in the upper jaw tooth fixing member (wire ring), the lower incisors and the tongue of the mouse are fixed by the elastic rope, the power of the pull hook is connected, and the angle of the pull hook on both sides is adjusted to enter the oral cavity of the mouse. The left and right corners of the mouse are pulled apart to achieve sufficient exposure and illumination of the oral cavity of the mouse in four directions (up, down, left and right), and then various oral cavity models of the mouse can be established.

[0023] Compared with the prior art, the experimental mouse oral operation device has the following beneficial effects and significant progress: the angle between the two plates can be freely adjusted, the body position of the mouse can be adjusted as needed, and the body and upper and lower jaws of the mouse can be fixed; the illuminated pull hook can be used to pull the corners of the mouse's mouth, illuminate the oral cavity, fully expose the oral cavity operation field, and perform oral cavity modeling operation in a bright and spacious space, thereby greatly improving the operation efficiency; the LED light belt is adopted, the light is softer, the stimulation of strong light on the eyes of the mouse can be reduced, and the requirements of animal ethics are also met; and the experimental mouse oral operation device provides objective experimental conditions for further research on the mechanism of the occurrence and development of oral diseases. BRIEF DESCRIPTION OF DRAWINGS

[0024] To make the technical solutions of the present application clearer, the following will briefly introduce the drawings needed for the embodiments of the present application.

[0025] Obviously, the drawings described below are only part of the drawings in the present application, and for those skilled in the art, other drawings can also be obtained from these drawings without creative labor, but these other drawings also belong to the drawings needed for the embodiments of the present application.

[0026] Figure 1 Structure diagram of an experimental mouse oral operation device in Example 2;

[0027] Figure 2 Partial detail view of an experimental mouse oral operation device in Example 2;

[0028] The drawings show that: 1, first plate; 2, second plate; 3-7, screw rod; 8, upper jaw tooth fixing member; 9-10, threaded hole; 11-14, long strip-shaped threaded groove; 15, support frame; 16-17, groove; 18, J-shaped hook body; 19, LED light belt; 20, data line; 21, USB socket; 22, rubber band. DETAILED DESCRIPTION

[0029] In order to make the purposes, technical solutions, beneficial effects and remarkable progress of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below.

[0030] Obviously, all the described embodiments are only part of the embodiments of the present application, but not all the embodiments; all the other embodiments obtained by those skilled in the art based on the embodiments in the present application without creative labor are within the protection scope of the present application.

[0031] It should be noted that the terms "first", "second" and "third" (if any) in the specification and claims of the present application are only used to distinguish different objects, and are not used to describe a specific order. In addition, the term "comprising" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but can optionally include steps or units not listed, or can optionally include other steps or units inherent to the process, method, product or device.

[0032] It should be understood that:

[0033] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "fixing" and the like should be understood in a broad sense, for example, can be fixed connection, can also be detachable connection or movable connection, or can be integrated; can be direct connection, or indirect connection through an intermediate medium or invisible signal connection, or even optical connection, can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise explicitly limited.

[0034] For those skilled in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0035] It should also be noted that the following specific embodiments can be combined with each other, and the same or similar concepts or processes in some embodiments can not be described again.

[0036] The technical solutions of the present application will be described in detail below with specific embodiments.

[0037] Embodiment 1

[0038] The experimental mouse oral cavity operating device comprises a first plate, a second plate, a first positioning assembly, a second positioning assembly, a third positioning assembly, a fourth positioning assembly, a fifth positioning assembly, a maxillary tooth fixing piece, a corner draw hook, a first elastic piece and a second elastic piece, the first plate and the second plate are foldably connected, the first positioning assembly, the second positioning assembly and the third positioning assembly are arranged on the first plate, and the first positioning assembly, the second positioning assembly and the third positioning assembly are distributed in a substantially equilateral triangle shape, the maxillary tooth fixing piece is arranged on the first positioning assembly, and the corner draw hook is connected to the second positioning assembly and the third positioning assembly through the first elastic piece.

[0039] In the embodiment, the first positioning assembly comprises a plurality of vertically distributed threaded holes and a screw rod matched with any threaded hole, and the maxillary tooth fixing piece is arranged on the screw rod.

[0040] In the embodiment, the second positioning assembly, the third positioning assembly, the fourth positioning assembly and the fifth positioning assembly comprise a long strip-shaped threaded groove and a screw rod.

[0041] In the embodiment, the corner draw hook comprises a J-shaped hook body and an LED lamp strip, the J-shaped hook body is hollow inside, the LED lamp strip is arranged in the inside of the J-shaped hook body, and the LED lamp strip is connected with a power supply.

[0042] In the embodiment, the first plate and the second plate are hingedly connected.

[0043] In the embodiment, a third plate and a support frame are further included, the third plate is arranged on the back of the first plate, a plurality of parallel arranged grooves are arranged on the third plate, and the two ends of the support frame are supported on the grooves and the first plate.

[0044] In the embodiment, the corner draw hook is made of silica gel material.

[0045] In the embodiment, the maxillary tooth fixing piece comprises a metal ring.

[0046] In the embodiment, the first elastic piece and the second elastic piece both comprise a rubber band.

[0047] In the embodiment, the folding inner angle of the first plate and the second plate is 95-180°.

[0048] Embodiment 2

[0049] As shown in the accompanying drawings, Figure 1 An experimental mouse oral cavity operating device comprises two flat plates, a first plate (a trapezoidal flat plate) 1 and a second plate (a square flat plate) 2 (wherein the first plate 1 can be adjusted in angle), the first plate and the second plate are connected through a hinge to form a workbench with adjustable angle, and the body position of the mouse can be flexibly adjusted according to the modeling needs.

[0050] The first positioning assembly comprises the threaded hole 9, the threaded hole 10 and the screw rod 3, and the second positioning assembly, the third positioning assembly, the fourth positioning assembly and the fifth positioning assembly each comprise a long strip-shaped threaded groove 11-14 and a screw rod 4-7.

[0051] The number of the screw rods 3-7 is five, and there is the screw rod 3 above the side of the mouse head, and there is the maxillary tooth fixing part 8 for fixing the maxillary incisor of the mouse on the screw rod 3; there are the screw rods 4 and 5 on both sides of the head of the mouse, and the rubber band is connected to the two hooks for pulling apart the corners of the mouth of the mouse; there are the screw rods 6 and 7 on both sides of the chest of the mouse, and the elastic rope is connected to the screw rods 6 and 7 for fixing the body of the mouse and pulling apart the tongue and the lower jaw of the mouse. The screw rods 3-7 are located on the long strip-shaped threaded grooves 11-14 or the threaded holes 9-10, and the mouse to be operated can be fixed according to the volume of the mouse and the required field of view of the operation.

[0052] The first plate 1 with adjustable angle is designed in a trapezoidal shape, which can increase the operation space of the hands of the operator when modeling while supporting the head of the mouse; the angle is adjusted through the support frame 15 and the grooves 16-17 on the base, and the support frame 15 is clamped in different grooves 16-17 on the base, so that the mouse is located in different body positions to meet the needs of the operator for modeling. Meanwhile, there is a concave surface on the back of the first plate 1, which can accommodate the third plate and the support frame, so that the trapezoidal flat plate 1 can be completely laid flat on the plane.

[0053] As shown in the accompanying drawings, Figure 2 The hook for pulling apart the corners of the mouth of the mouse is made of a J-shaped hook body (silicone tube) 18 with a diameter of 2-2.5 mm, the silicone material is flexible and insulating, does not harm the oral mucosa of the mouse, and also avoids the risk of electric shock of the mouse when placed in the oral cavity of the mouse; the J-shaped hook body 18 is hollow inside and has an LED light strip 19, which is connected to a USB socket 21 through a data line 20 after the silicone tube to be used after being plugged in, and can also illuminate the oral cavity of the mouse when the corners of the mouth of the mouse are gently pulled apart during modeling; the end of the J-shaped hook body 18 is provided with two holes, and the rubber band 22 is connected to the screw rod and fixed on the screw rod, and the rubber band is used to pull apart the corners of the mouth of the mouse.

[0054] The LED light strip 19 uses soft light LED beads, which can converge the light and be bright without being dazzling, and can protect the eyes of the operator and the mouse.

[0055] In the description of the above specification:

[0056] The terms "the present embodiments", "the present embodiments", "as shown", "further", "further improved technical solutions" and the like mean that the specific features, structures, materials or characteristics described in the embodiments or examples are included in at least one embodiment or example of the present application; in the specification, the illustrative description of the above terms is not necessarily for the same embodiment or example, and the specific features, structures, materials or characteristics described can be combined or combined in any one or more embodiments or examples in a suitable manner; in addition, the ordinary skilled in the art can combine or combine the different embodiments or examples described in the specification and the features of the different embodiments or examples without contradiction.

[0057] Finally, it should be noted that:

[0058] The above embodiments are only used to illustrate the technical solutions of the present application, but not to limit them;

[0059] Although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that they can modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for part or all of the technical features, and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application. The non-essential improvements and adjustments or replacements made by the skilled in the art according to the content of the specification are all within the scope of the present application.

Claims

1. A device for manipulating the oral cavity of laboratory mice, characterized in that, It includes a first plate, a second plate, a first positioning component, a second positioning component, a third positioning component, a fourth positioning component, a fifth positioning component, a maxillary tooth fixation component, a corner hook, a first elastic component, and a second elastic component. The first plate and the second plate are foldable and connected, and the folding inner angle between the first plate and the second plate is 95-180°. The first positioning component, the second positioning component, and the third positioning component are disposed on the first plate, and the first positioning component, the second positioning component, and the third positioning component are generally distributed in an equilateral triangle. The first positioning component is provided with a maxillary tooth fixing component, and the corner hooks are respectively connected to the second positioning component and the third positioning component through a first elastic component. The fourth positioning component and the fifth positioning component are disposed on the second plate, and the second elastic member connects the fourth positioning component and the fifth positioning component; The first positioning component includes a plurality of vertically distributed threaded holes and a screw that matches any of the threaded holes, and the maxillary tooth fixation member is disposed on the screw; The second positioning component, the third positioning component, the fourth positioning component, and the fifth positioning component each include an elongated threaded groove and a screw. The corner hook includes a J-shaped hook body and an LED light strip. The J-shaped hook body is made of silicone material and is hollow inside. The LED light strip is disposed inside the J-shaped hook body and is connected to an external power source.

2. The experimental mouse oral manipulation device as described in claim 1, characterized in that, The first plate and the second plate are hinged together.

3. The experimental mouse oral manipulation device as described in claim 2, characterized in that, It also includes a third plate and a support frame. The third plate is disposed on the back of the first plate and has a plurality of parallel grooves. The two ends of the support frame are respectively supported on the grooves and the first plate.

4. The experimental mouse oral manipulation device as described in claim 1, characterized in that, The maxillary tooth fixation device includes a metal ring.

5. The experimental mouse oral manipulation device as described in claim 1, characterized in that, Both the first elastic element and the second elastic element include rubber bands.

Images