A Chinese herbal ointment for treating leukoplakia vulvae

Abstract

The present invention discloses a Chinese herbal medicine paste for treating leukoplakia of vulva, which relates to the technical field of traditional Chinese medicine preparation. It is made from the following components in parts by weight: 25-30 parts of angelica dahurica, 20-35 parts of motherwort, 20-27 parts of capillaris, 15-20 parts of Chinese angelica, 10-18 parts of plantain seed, 10-15 parts of poria cocos, 5-10 parts of frankincense, 5-10 parts of mint, 4-8 parts of coelogyne cristata, 2-7 parts of cnidium monnieri, 2-7 parts of borneol, and 1-3 parts of realgar. This Chinese herbal medicine paste for treating leukoplakia of vulva has the functions of expelling wind and killing insects, clearing heat and removing dampness, eliminating macules and relieving itching, promoting blood circulation to stop pain, and can effectively repair vulvar skin lesions, promote skin regeneration, and restore the normal shape of vulvar skin.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparation, and specifically relates to a traditional Chinese herbal paste for treating leukoplakia of vulva. Background Art

[0002] Leukoplakia of vulva is also known as white lesions of vulva, vulvar dystrophy, vulvar nutritional disorder, etc. Its incidence rate accounts for about 5 - 10% of the total number of women. This disease is not contagious, but can be inherited with a very high inheritance rate. Based on this, the World Health Organization has officially classified it as a pre-cancerous lesion. The Chinese Academy of Traditional Chinese Medicine has also listed it as a world-wide intractable disease. It is a difficult gynecological disease caused by local pigment loss of the vulvar skin of women, resulting in white, rough, thickened, hardened, chapped, desquamated skin and mucous membranes, or reduced elasticity of the vulvar skin and mucous membranes, and even atrophy and disappearance of the labia minora and majora.

[0003] Its symptoms are: itching, dryness, hardening, burning pain in the vulva; focal or diffuse white thickened plaques appear around the labia minora or majora, perineum, and anus, with a rough surface and cracks and ulcers. Some show local thinning of the skin and mucous membranes, reduced elasticity, and obvious shrinkage or even disappearance of the labia minora and majora.

[0004] Existing treatment methods: 1. Drug treatment: After cleaning the vulva with a female care solution with a pH4 weak acid formula, locally apply hormone drugs, locally inject Clostridium perfringens anaerobes, and traditional Chinese medicine treatment, etc.

[0005] 2. Physical treatment: Microwave treatment, carbon dioxide laser, helium-neon laser, Bome light, high-frequency electric knife, local electrocautery treatment, and local cryotherapy with liquid nitrogen, etc.

[0006] 3. Surgical treatment: Simple vulvectomy, vulvectomy combined with skin grafting.

[0007] Compared with physical treatment and surgical treatment that can cause irreversible damage, drug treatment is more acceptable to patients.

[0008] Therefore, it is very necessary to propose a traditional Chinese herbal paste for treating leukoplakia of vulva to solve the above problems. Summary of the Invention

[0009] The purpose of the present invention is to provide a traditional Chinese herbal paste for treating leukoplakia of vulva with a wide range of drug sources, low cost, good curative effect and no toxic and side effects.

[0010] To achieve the above purpose, the present invention is realized through the following technical solutions: A traditional Chinese herbal paste for treating leukoplakia of vulva is made from the following components in parts by weight:

[0011] Angelica dahurica 25 - 30 parts, Leonurus japonicus 20 - 35 parts, Artemisia capillaris 20 - 27 parts, Angelica sinensis 15 - 20 parts, Plantago asiatica 10 - 18 parts, Poria cocos 10 - 15 parts, Olibanum 5 - 10 parts, Mentha haplocalyx 5 - 10 parts, Coelogyne cristata 4 - 8 parts, Cnidium monnieri 2 - 7 parts, Borneol 2 - 7 parts, Realgar 1 - 3 parts.

[0012] Preferably, it is made of the following components in parts by weight: Angelica dahurica 27 parts, Leonurus japonicus 27 parts, Artemisia capillaris 23 parts, Angelica sinensis 17 parts, Plantago asiatica 14 parts, Poria cocos 13 parts, Olibanum 7 parts, Mentha haplocalyx 7 parts, Coelogyne cristata 5 parts, Cnidium monnieri 5 parts, Borneol 5 parts, Realgar 2 parts.

[0013] A preparation method of a Chinese herbal medicine ointment for treating leukoplakia vulvae, the specific steps are as follows:

[0014] Step (1): Remove impurities from Angelica dahurica, Leonurus japonicus, Artemisia capillaris, Angelica sinensis, Poria cocos, Mentha haplocalyx, and Coelogyne cristata, wash them, dry them, and then mix and crush them into coarse powder according to the ratio for standby.

[0015] Step (2): Grind Plantago asiatica, Cnidium monnieri, Borneol, and Olibanum into fine powder respectively for standby.

[0016] Step (3): Levigate Realgar with water or crush it into extremely fine powder for standby.

[0017] Step (4): Grind the coarse powder obtained in step (1), the fine powder obtained in step (2), and the extremely fine powder obtained in step (3) evenly together.

[0018] Step (5): Add an emulsion matrix with a weight 0.2 - 0.5 times that of the Chinese medicine to the mixture obtained in step (4), stir evenly, and then the Chinese herbal medicine ointment for treating leukoplakia vulvae is obtained.

[0019] The emulsion matrix is one or more of vegetable oil, beeswax, petrolatum, and animal fat.

[0020] The theoretical basis of the present invention is:

[0021] Leonurus japonicus: It has the effects of promoting blood circulation to regulate menstruation, diuretic and detumescence, clearing heat and detoxifying. It is mainly used for irregular menstruation, dysmenorrhea and amenorrhea, lochia not yet exhausted, edema with oliguria, sores and carbuncles; Angelica dahurica: It has the effects of inducing sweating to dispel cold, expelling wind and relieving pain, drying dampness and arresting leukorrhea, detumescence and discharging pus, expelling wind and relieving itching. It is mainly used for leukorrhea syndrome, sores and carbuncles, skin rheumatism and itching; Artemisia capillaris: It has the effects of clearing away damp-heat and promoting bile flow to remove jaundice. It is mainly used for jaundice with oliguria, damp-warm syndrome in summer and damp sores with itching; Plantago asiatica: It has the effect of clearing away damp-heat; Angelica sinensis: It has the effects of enriching blood and regulating menstruation, promoting blood circulation and relieving pain. It is mainly used for sallow complexion due to blood deficiency, rheumatic arthralgia, carbuncles and sores; Poria cocos: It has the effects of promoting diuresis and detumescence, percolating dampness, strengthening the spleen and calming the mind. It is mainly used for edema, diarrhea due to spleen deficiency; Olibanum: It has the effects of promoting blood circulation and qi movement to relieve pain, detumescence and promoting granulation. It is mainly used for promoting blood circulation and qi movement to relieve pain, detumescence and promoting granulation, qi stagnation and blood stasis pain; Mentha haplocalyx: It has the effects of dispersing wind-heat, clearing the head and eyes, and promoting eruption and relieving itching. It is mainly used for measles not yet erupted, rubella with itching, stagnation of liver qi; Coelogyne cristata: It stops bleeding and relieves pain. It is mainly used for traumatic bleeding, soft tissue contusion; Cnidium monnieri: It has the effects of drying dampness and killing insects, expelling wind and relieving itching. It is mainly used for itching in the pudendal area, eczema, scabies; Borneol: It has the effects of resuscitating the patient from unconsciousness, clearing heat and relieving pain. It is mainly used for swelling and pain of sores and ulcers, non-healing of ulcers, scalds and burns, and can promote the drug to quickly penetrate the skin surface to reach the lesion, which is beneficial to the exertion of medicinal ingredients; Realgar: It has the effects of detoxifying and killing insects, drying dampness and resolving phlegm, and arresting malaria. It is mainly used for carbuncles, sores and furuncles, snake and insect bites, abdominal pain due to worm accumulation, epilepsy, malaria.

[0022] The present invention has the following beneficial effects:

[0023] The Chinese herbal medicine paste for treating vulvar leukoplakia is prepared from easily available raw materials, with low procurement cost, convenient application of the prepared paste, and no toxic and side effects; the Chinese herbal medicine paste has the functions of expelling wind and killing insects, clearing heat and removing dampness, eliminating macules and relieving itching, promoting blood circulation and relieving pain, can effectively repair vulvar skin lesions, promote skin regeneration, and restore the normal shape of vulvar skin. Specific embodiments

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments.

[0025] Embodiment 1

[0026] A Chinese herbal medicine paste for treating vulvar leukoplakia, comprising 25 parts of Angelica dahurica, 20 parts of Leonurus japonicus, 20 parts of Artemisia capillaris, 15 parts of Angelica sinensis, 10 parts of Plantago asiatica, 10 parts of Poria cocos, 5 parts of Olibanum, 5 parts of Mentha haplocalyx, 4 parts of Coelogyne cristata, 2 parts of Cnidium monnieri, 2 parts of Borneol, and 1 part of Realgar.

[0027] The specific preparation steps are as follows:

[0028] Step (1): Remove impurities from Angelica dahurica, Leonurus japonicus, Artemisia capillaris, Angelica sinensis, Poria cocos, Mentha haplocalyx, and Coelogyne cristata, wash them, dry them, mix them in proportion, and pulverize them into coarse powder for standby; Step (2): Grind Plantago asiatica, Cnidium monnieri, Borneol, and Olibanum into fine powder respectively for standby; Step (3): Levigate realgar or pulverize it into extremely fine powder for standby; Step (4): Grind the coarse powder obtained in Step (1), the fine powder obtained in Step (2), and the extremely fine powder obtained in Step (3) evenly together; Step (5): Add vaseline in an amount 0.2 times the amount of traditional Chinese medicine to the mixture obtained in Step (4), stir evenly, and then obtain the Chinese herbal medicine ointment for treating vulvar leukoplakia.

[0029] Example 2

[0030] A Chinese herbal medicine ointment for treating vulvar leukoplakia includes 27 parts of Angelica dahurica, 27 parts of Leonurus japonicus, 23 parts of Artemisia capillaris, 17 parts of Angelica sinensis, 14 parts of Plantago asiatica, 13 parts of Poria cocos, 7 parts of Olibanum, 7 parts of Mentha haplocalyx, 5 parts of Coelogyne cristata, 5 parts of Cnidium monnieri, 5 parts of Borneol, and 2 parts of realgar.

[0031] The specific preparation steps are as follows:

[0032] Step (1): Remove impurities from Angelica dahurica, Leonurus japonicus, Artemisia capillaris, Angelica sinensis, Poria cocos, Mentha haplocalyx, and Coelogyne cristata, wash them, dry them, mix them in proportion, and pulverize them into coarse powder for standby; Step (2): Grind Plantago asiatica, Cnidium monnieri, Borneol, and Olibanum into fine powder respectively for standby; Step (3): Levigate realgar or pulverize it into extremely fine powder for standby; Step (4): Grind the coarse powder obtained in Step (1), the fine powder obtained in Step (2), and the extremely fine powder obtained in Step (3) evenly together; Step (5): Add vaseline in an amount 0.3 times the amount of traditional Chinese medicine to the mixture obtained in Step (4), stir evenly, and then obtain the Chinese herbal medicine ointment for treating vulvar leukoplakia.

[0033] Example 3

[0034] A Chinese herbal medicine ointment for treating vulvar leukoplakia includes 30 parts of Angelica dahurica, 35 parts of Leonurus japonicus, 27 parts of Artemisia capillaris, 20 parts of Angelica sinensis, 18 parts of Plantago asiatica, 15 parts of Poria cocos, 10 parts of Olibanum, 10 parts of Mentha haplocalyx, 8 parts of Coelogyne cristata, 7 parts of Cnidium monnieri, 7 parts of Borneol, and 3 parts of realgar.

[0035] The specific preparation steps are as follows:

[0036] Step (1): Remove impurities from Angelica dahurica, Leonurus japonicus, Artemisia capillaris, Angelica sinensis, Poria cocos, Mentha haplocalyx, and Coelogyne cristata, wash them, dry them, mix them in proportion, and pulverize them into coarse powder for standby; Step (2): Grind Plantago asiatica, Cnidium monnieri, Borneol, and Olibanum into fine powder respectively for standby; Step (3): Levigate realgar or pulverize it into extremely fine powder for standby; Step (4): Grind the coarse powder obtained in Step (1), the fine powder obtained in Step (2), and the extremely fine powder obtained in Step (3) evenly together; Step (5): Add vaseline in an amount 0.5 times the amount of traditional Chinese medicine to the mixture obtained in Step (4), stir evenly, and then obtain the Chinese herbal medicine ointment for treating vulvar leukoplakia.

[0037] Observation on the Efficacy of Treating Vulvar Leukoplakia

[0038] In this invention, 124 patients were clinically selected. Among the 124 patients, 56 were of the proliferative type, 46 were of the atrophic type, and 22 were of the mixed type. The patients were divided into two groups, namely the treatment group and the control group, with each type having half of the patients in each group.

[0039] Application method: The control group applied other external ointments daily according to the instructions; the treatment group applied the Chinese herbal paste prepared in Example 2 of this invention daily, twice a day. After keeping it for 30 minutes each time, it was washed. 30 days was taken as one course of treatment.

[0040] Efficacy criteria:

[0041] Cured: The subjective symptoms disappeared, the local tissue became soft, and the elasticity and the color of the skin and mucosa returned to normal;

[0042] Markedly effective: The subjective symptoms disappeared, the ulcer healed, the elasticity basically recovered, the skin and mucosa showed purple-red color, and the lesion range was reduced by 1 - 2 cm compared with that before treatment;

[0043] Improved: The subjective symptoms disappeared, but there were occasional relapses. The local elasticity recovered somewhat, the leukoplakia area showed pink or pink and white intermingled, and the keratinization was reduced;

[0044] Ineffective: There was no change before and after treatment.

[0045] Treatment results after 3 courses:

[0046]

[0047] Treatment results: Among the 62 patients in the treatment group, 50 were cured, with a cure rate of 81%, 58 were markedly effective, with a marked effective rate of 94%, and 0 were ineffective. The results show that the Chinese herbal paste of this invention can treat vulvar leukoplakia.

[0048] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese herbal medicine paste for treating leukoplakia vulvae, characterized in that, it is made of the following components in parts by weight: 25 - 30 parts of angelica dahurica, 20 - 35 parts of motherwort, 20 - 27 parts of capillaris, 15 - 20 parts of angelica sinensis, 10 - 18 parts of plantain seed, 10 - 15 parts of poria cocos, 5 - 10 parts of frankincense, 5 - 10 parts of mint, 4 - 8 parts of coelogyne cristata, 2 - 7 parts of fructus cnidii, 2 - 7 parts of borneol, 1 - 3 parts of realgar.

2. The Chinese herbal medicine paste for treating leukoplakia vulvae according to claim 1, characterized in that: it is made of the following components in parts by weight: 27 parts of angelica dahurica, 27 parts of motherwort, 23 parts of capillaris, 17 parts of angelica sinensis, 14 parts of plantain seed, 13 parts of poria cocos, 7 parts of frankincense, 7 parts of mint, 5 parts of coelogyne cristata, 5 parts of fructus cnidii, 5 parts of borneol, 2 parts of realgar.

3. The Chinese herbal medicine paste for treating leukoplakia vulvae according to claim 1 or 2, characterized in that, the specific steps of the paste preparation method are: Step (1): Remove impurities from angelica dahurica, motherwort, capillaris, angelica sinensis, poria cocos, mint, and coelogyne cristata, wash and dry them, and then mix and crush them into coarse powder according to the ratio for standby; Step (2): Grind plantain seed, fructus cnidii, borneol, and frankincense into fine powder respectively for standby; Step (3): Levigate realgar or crush it into extremely fine powder for standby; Step (4): Grind the coarse powder obtained in step (1), the fine powder obtained in step (2), and the extremely fine powder obtained in step (3) evenly together; Step (5): Add an emulsion matrix with a quantity 0.2 - 0.5 times the amount of the traditional Chinese medicine to the mixture obtained in step (4), stir evenly to obtain the Chinese herbal medicine paste for treating leukoplakia vulvae.

4. The Chinese herbal medicine paste for treating leukoplakia vulvae according to claim 3, characterized in that: the emulsion matrix is one or more of vegetable oil, beeswax, petrolatum, and animal fat.

Images