Enclosed cryogenic carrier

Abstract

The application discloses a closed frozen carrier rod, which comprises a hollow outer sleeve and a carrier rod sleeved in the outer sleeve, wherein a counterweight is arranged on the outer sleeve and close to one end of the outer sleeve; one end of the carrier rod is fixed with a slide for placing a biological sample, and the other end of the carrier rod away from the slide is provided with a handle; the carrier rod further comprises a hard tube arranged between the handle and the slide; when the carrier rod is sleeved with the outer sleeve, the end of the outer sleeve provided with the counterweight is close to the end of the carrier rod where the slide is arranged; the slide is provided with a groove, and the biological sample is placed in the groove; the groove on the slide comprises a bottom wall and two side walls arranged on the opposite sides of the bottom wall, the distance between the two side walls increases in the direction away from the bottom wall, and the included angle alpha between the bottom wall and the side wall is in the range of 120 DEG ≤ alpha < 180 DEG.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of reproductive medicine, in particular to a closed freezing carrier. BACKGROUND

[0002] At present, the vitrification freezing carrier is divided into an open freezing carrier and a closed freezing carrier. The open freezing carrier can directly contact liquid nitrogen, so that rapid cooling and reduction of ice crystal damage can be achieved. However, the open freezing carrier is prone to cross contamination between embryos due to direct contact with liquid nitrogen. Therefore, the closed freezing carrier is usually used for freezing embryos in an assisted reproductive center.

[0003] The existing closed freezing carrier, such as the closed freezing carrier disclosed in Chinese Patent No. CN218499880U, comprises a carrier, a counterweight, an inner sleeve and an outer sleeve. The carrier comprises a connecting portion, a hand holding portion and a carrier sheet portion arranged at both ends of the connecting portion, respectively. The counterweight comprises a hollow nesting portion, a hollow portion and a solid portion. One end of the hollow nesting portion is fully open, and the other end is closed but has a through hole for the carrier sheet portion of the carrier to pass through. The closed end of the hollow nesting portion is fixedly connected with the solid portion through a support to form the hollow portion. The inner sleeve is a hollow pipe structure. The upper end of the inner sleeve is detachably connected with the connecting portion of the carrier, and the inner sleeve sleeves the connecting portion and part of the carrier sheet portion. The lower end of the inner sleeve is matched in size with the hollow nesting portion to realize detachable connection between the inner sleeve and the counterweight. The outer sleeve is a hollow structure with one end fully open and the other end fully closed. The outer sleeve is sleeved on the outer side of the inner sleeve and the counterweight after detachable connection. The counterweight corresponds to the closed end of the outer sleeve, and the hand holding portion of the carrier corresponds to the open end of the sleeve.

[0004] However, the closed freezing carrier provided by the above patent has a large volume and is difficult to operate, which cannot meet the use requirements of clinics and laboratories, and the biological samples on the carrier sheet have a risk of falling off. SUMMARY

[0005] To solve the problems in the prior art, the present application discloses a closed freezing carrier.

[0006] A closed freezing carrier comprises a hollow outer sleeve and a carrier sleeved in the outer sleeve. A counterweight is arranged on the outer sleeve, and the counterweight is arranged close to one end of the outer sleeve.

[0007] One end of the carrier is fixed with a carrier sheet for placing biological samples, and the end of the carrier away from the carrier sheet is provided with a handle. When the carrier is sleeved with the outer sleeve, the end of the outer sleeve provided with the counterweight is close to the end of the carrier where the carrier sheet is arranged.

[0008] The carrier sheet is provided with a groove, and the biological sample is placed in the groove; the groove on the carrier sheet comprises a bottom wall and two side walls arranged on opposite sides of the bottom wall, the distance between the two side walls increases in the direction away from the bottom wall, and the included angle a between the bottom wall and the side wall ranges from 120° to 180°.

[0009] Specifically, a counterweight is arranged at one end of the outer sleeve, and the position of the counterweight is close to the position of the carrier sheet after the carrier rod is sleeved with the outer sleeve, so that the end where the counterweight is located is always downward due to the action of gravity when the closed freezing carrier rod is stored. This structure ensures that the biological sample on the carrier sheet is always in a low-temperature environment of the freezing liquid, and also ensures that the position of the closed freezing carrier rod is stable and will not float on the freezing liquid or shake.

[0010] The structure of the groove arranged on the carrier sheet can effectively limit the position of the biological sample and reduce the possibility of loss. Compared with the ring-shaped carrier sheet in the prior art, the carrier sheet with the groove provided by the application can shorten the distance between the biological sample on the carrier sheet and the freezing liquid, so that the biological sample can be frozen more quickly.

[0011] The structure that the distance between the two side walls gradually increases in the direction away from the bottom wall makes it very convenient to take and place the biological sample on the groove.

[0012] Preferably, the bottom wall of the groove is provided with a first hollow part penetrating the bottom wall, and the width a of the first hollow part ranges from 0 to 100 μm.

[0013] More preferably, the two side walls of the groove are both provided with a second hollow part, the second hollow parts are arranged in pairs and penetrate the respective side walls, and the width b of the second hollow part ranges from 0 to 200 μm.

[0014] Specifically, the change of the radius of the liquid drop wrapping the biological sample on the carrier sheet will cause the change of the osmotic pressure, i.e. the biological sample is in an environment with changing osmotic pressure, which is easy to cause the loose of the chromatin structure and further increase the damage to DNA. The structure of the first / second hollow part arranged on the groove can effectively reduce the spreadability of the liquid drop in the groove, maintain the relative invariability of the radius of the liquid drop, and further ensure that the biological sample is in an environment with stable osmotic pressure, thereby reducing the probability of DNA damage.

[0015] Preferably, the outer diameter of the carrier sheet ranges from 1.2 to 1.6 mm.

[0016] Preferably, the thickness of the slide is no more than 0.28mm.

[0017] Preferably, the carrier rod further comprises a hard tube arranged between the handle and the slide, and a convex strip is arranged on the carrier rod between the hard tube and the slide / handle, which is used to prevent the carrier rod from moving when the carrier rod is sleeved in the sleeve tube.

[0018] Specifically, the carrier rod is provided with a hard tube, which has a large hardness and cannot be cut by scissors. The hard tube can be made of metal. When the biological sample on the slide needs to be taken out, the sleeve tube is cut at the position corresponding to the hard tube, and then the carrier rod can be taken out. Since the sleeve tube is usually made of plastic, it is very easy to cut. However, since the sleeve tube is cut at the position corresponding to the hard tube, the carrier rod will not be damaged, thereby reducing the possibility of damage to the carrier rod during the process of taking out the carrier rod.

[0019] If the carrier rod is sleeved with the sleeve tube, the relative position between the two cannot be stable, or the interference between the slide and the inner wall of the sleeve tube will occur, thereby damaging the biological sample on the slide, and even more, the carrier rod will fall out of the sleeve tube. Therefore, it is necessary to set the convex strip structure to stabilize the relative position between the carrier rod and the sleeve tube.

[0020] Preferably, the carrier rod between the hard tube and the slide / handle is provided with an exhaust groove, and the exhaust groove is at least one. When the carrier rod is sleeved into the sleeve tube, at least part of the gas in the sleeve tube is discharged through the exhaust groove.

[0021] Specifically, since the sleeve tube and the carrier rod are both of an elongated structure, the air in the sleeve tube must be discharged during the sleeving process, otherwise it is difficult to completely sleeve the carrier rod into the sleeve tube due to the pressure difference resistance. Therefore, it is appropriate to set the exhaust groove structure to assist in exhaust.

[0022] Preferably, the counterweight comprises a body with a diameter smaller than the inner diameter of the sleeve tube and a guide table arranged at one end of the body. The guide table is a circular truncated cone, and the diameter decreases away from the body. The minimum diameter of the guide table is smaller than the inner diameter of the sleeve tube, and the maximum diameter is larger than the inner diameter of the sleeve tube.

[0023] Preferably, the body of the counterweight is provided with at least one annular boss, and the diameter of the annular boss is larger than the inner diameter of the sleeve tube.

[0024] Specifically, to stabilize the relative position between the counterweight and the outer sleeve, on one hand, the counterweight can be pre-buried when the outer sleeve is prepared, so that the counterweight is integrally injection molded with the outer sleeve; on the other hand, the structure of the counterweight can be designed, the structure of the counterweight provided by the application utilizes the structure of the guide table to enable the counterweight to be smoothly pushed into the outer sleeve, and at the same time, since the maximum diameter of the guide table is greater than the inner diameter of the outer sleeve, the guide table is tightly fitted with the outer sleeve, and in addition, a plurality of annular bosses with a diameter greater than the inner diameter of the outer sleeve are arranged on the counterweight, so that the stability of the relative position between the outer sleeve and the counterweight can be further improved, and displacement of the counterweight in the outer sleeve and damage to the biological sample on the carrier are avoided.

[0025] Preferably, at least one end of the outer sleeve is provided with a guide port, and the diameter of the guide port increases in the direction away from the outer sleeve.

[0026] Specifically, the structure of the guide port reduces the assembly difficulty between the outer sleeve and the carrier rod and the counterweight.

[0027] In addition, if the outer sleeve and the counterweight are integrally formed, the outer sleeve has a structure with one end open and the other end sealed, and after the carrier rod is inserted into the outer sleeve, the open end needs to be sealed;

[0028] If the outer sleeve and the counterweight are not integrally formed, the outer sleeve has a structure with both ends open, and after the counterweight is inserted into the outer sleeve, the open end close to the counterweight is sealed first, and after the carrier rod is inserted into the outer sleeve, the other end is sealed.

[0029] Compared with the prior art, the application has the following advantages:

[0030] 1. By arranging the groove on the carrier, the stability of the biological sample placed in the groove of the carrier is significantly improved, the risk of the biological sample falling off the carrier is effectively reduced, and most of the surface of the biological sample placed on the carrier is separated from the freezing liquid by only one layer of the outer sleeve, thereby improving the freezing rate of the to-be-frozen tissue.

[0031] 2. By arranging the first hollow part / second hollow part on the groove, the spreadability of the liquid drop in the groove is effectively reduced, the radius of the liquid drop is relatively unchanged, and the biological sample is kept in an environment with stable osmotic pressure, thereby reducing the damage probability of DNA.

[0032] 3、Through the structure of fixing the hard tube on the carrier rod, the disassembly difficulty between the carrier rod and the outer sleeve is reduced, and the possibility of damaging the frozen tissue / frozen tissue when the carrier rod is taken out is reduced.

[0033] 4、Through the structure of designing the counterweight block with a guide table and an annular boss, the structure and volume of the counterweight block are simplified under the premise of ensuring that the counterweight block does not displace relative to the outer sleeve, and the volume and operation difficulty of the closed freezing carrier rod are reduced, so that the closed freezing carrier rod provided by the application is more practical. BRIEF DESCRIPTION OF DRAWINGS

[0034] Figure 1 The whole structure schematic diagram of the carrier rod of the closed freezing carrier rod provided by the application;

[0035] Figure 2 The cross-sectional view of the carrier sheet of the closed freezing carrier rod provided by the application, which is provided with a first hollow part;

[0036] Figure 3 The cross-sectional view of the carrier sheet of the closed freezing carrier rod provided by the application, which is provided with two first hollow parts;

[0037] Figure 4 The cross-sectional view of the carrier sheet of the closed freezing carrier rod provided by the application, which is provided with a pair of second hollow parts;

[0038] Figure 5 The schematic diagram of the outer sleeve of the closed freezing carrier rod provided by the application;

[0039] Figure 6 The schematic diagram of the counterweight block of the closed freezing carrier rod provided by the application;

[0040] Figure 7 The assembly schematic diagram of the closed freezing carrier rod provided by the application;

[0041] Figure 8 The assembly process schematic diagram of the closed freezing carrier rod provided by the application;

[0042] Figure 9 The picture of the cooling efficiency of the carrier sheet of the closed freezing carrier rod provided by the application, which is provided with a second hollow part;

[0043] Figure 10 The Figure 9 The enlarged schematic diagram of A in FIG. 8;

[0044] Figure 11 The picture of the cooling efficiency of the carrier sheet of the closed freezing carrier rod provided by the application, which is provided with a first hollow part;

[0045] Figure 12 The Figure 11 The enlarged schematic diagram of B in FIG. 8;

[0046] Figure 13 The closed freezing carrier provided by the present application is provided with a second hollow part and a first hollow part, and the cooling efficiency comparison chart of the first hollow part and the second hollow part. DETAILED DESCRIPTION

[0047] The present application will be further described in conjunction with the drawings and specific embodiments.

[0048] As shown in Figure 1 , 5 , the closed freezing carrier comprises a hollow outer sleeve 10 and a carrier 20 sleeved in the outer sleeve 10, and a counterweight 30 is arranged on the outer sleeve 10, and the counterweight 30 is arranged close to one end of the outer sleeve 10.

[0049] One end of the carrier 20 is fixed with a slide 40 for placing a biological sample, and the end of the carrier 20 away from the slide 40 is provided with a handle 21; when the carrier 20 is sleeved with the outer sleeve 10, the end of the outer sleeve 10 provided with the counterweight 30 is close to the end of the carrier 20 where the slide 40 is located.

[0050] The slide 40 is provided with a groove 41, and the biological sample (the biological sample can be an ovum, an oocyte, a zygote, a blastocyst and an embryonic cell and / or multicellular body derived from a human, a non-human primate, a dog, a cow, a horse, a pig, a sheep, a goat, a cat, a water buffalo, a guinea pig, a hamster, a rabbit, a rat and a mouse, etc.) is placed in the groove 41; the groove 41 on the slide 40 comprises a bottom wall 42 and two side walls 43 arranged on the opposite sides of the bottom wall 42, the distance between the two side walls 43 increases in the direction away from the bottom wall 42, and the included angle α between the bottom wall 42 and the side wall 43 is in the range of 120°≤α<180°.

[0051] The counterweight 30 is arranged on one end of the outer sleeve 10, and after the carrier 20 is sleeved with the outer sleeve 10, the position of the counterweight 30 is close to the position of the slide 40, so when the closed freezing carrier is frozen in the freezing solution, due to the action of gravity, the end where the counterweight 30 is located is always downward, and this structure not only ensures that the biological sample on the slide 40 is always in the low-temperature environment of the freezing solution, but also ensures that the position of the whole closed freezing carrier is stable and will not float on the freezing solution or shake;

[0052] The biological sample is placed in the groove 41. Compared with the flat slide, the groove 41 on the slide 40 can effectively limit the position of the biological sample to reduce the possibility of loss. In addition, compared with the circular ring slide in the prior art, the slide 40 with the groove 41 provided in the embodiment can shorten the distance between the biological sample on the slide 40 and the freezing liquid, thereby enabling the biological sample to be frozen more quickly.

[0053] The two side walls 43 gradually increase in distance away from the bottom wall 42, which makes it very convenient to place and take the biological sample on the groove 41.

[0054] As shown in Figure 2 , 3 , the bottom wall 42 of the groove 41 is provided with a first hollow part 44 penetrating the bottom wall 42, and the width a of the first hollow part 44 is in the range of 0 < a ≤ 100 μm.

[0055] As shown in Figures 11-12 , when the slide 40 is provided with the groove 41 with the first hollow part 44, and the width a of the first hollow part 44 is in the range of 0 < a ≤ 100 μm, the time required for the biological sample placed on the slide 40 to be cooled to -130℃ is less than that of the slide in the prior art (flat and without hollow part). According to the prior art, the time required for the biological sample to be cooled to -130℃ is the most critical, and the shorter the time, the less damage to the biological sample on the slide 40. That is, the biological sample is placed on such a slide 40 for freezing, and the damage to the biological sample is smaller. According to the accompanying drawings Figures 11-12 , when a = 0, the freezing rate is the fastest, that is, when the first hollow part 44 is not provided, the freezing rate is the fastest. However, at this time, the droplet wrapping the biological sample on the slide 40 has good ductility, so that the size of the droplet frequently changes, causing the biological sample to be in an environment with changing osmotic pressure, which can easily cause chromatin structure to be loose, thereby increasing the damage to DNA. The structure of the first hollow part 44 can effectively reduce the ductility of the droplet in the groove 41, maintain the relative invariability of the radius of the droplet, and thus ensure that the biological sample is in an environment with stable osmotic pressure, thereby reducing the probability of DNA damage.

[0056] As shown in Figure 4 , the two side walls 43 of the groove 41 are each provided with a second hollow part 45, and the second hollow part 45 is provided in pairs and penetrates the side wall 43 where it is located. The width b of the second hollow part 45 is in the range of 0 < b ≤ 200 μm.

[0057] As shown in Figures 9-10As shown, when the groove 41 with the second hollow part 45 is arranged on the carrier 40, and the width b of the second hollow part 45 is in the range of 0≤b≤200μm, the time required for the biological sample placed on the carrier 40 to be cooled to-130℃ is less than that of the carrier in the prior art (the carrier without the groove and in the flat type); that is, the biological sample is less damaged when it is frozen on the carrier 40; and according to the attached Figures 9-10 It can be seen that when b=0, the freezing rate is the fastest, that is, when the second hollow part 45 is not arranged, the freezing rate is the fastest, but at this time, the droplet wrapping the biological sample on the carrier 40 has good ductility, so that the size of the droplet frequently changes and the biological sample is in an environment with changing osmotic pressure, which easily causes the chromatin structure to be loose and further increases the damage to DNA. The structure of the second hollow part 45 can effectively reduce the ductility of the droplet in the groove 41, maintain the relative invariability of the radius of the droplet, and further ensure that the biological sample is in an environment with stable osmotic pressure, thereby reducing the probability of DNA damage.

[0058] As shown in the figure, the cooling efficiency of the carrier 40 is faster than that of the carrier in the prior art. Figure 13 As shown in the figure, the cooling efficiency of the carrier 40 is faster than that of the carrier in the prior art.

[0059] The outer diameter of the carrier 40 is in the range of 1.2-1.6mm.

[0060] The thickness of the carrier 40 is not more than 0.28mm.

[0061] The carrier 40 further comprises a hard tube 22 arranged between the handle 21 and the carrier 40, and a convex strip 23 is arranged on the carrier 20 between the hard tube 22 and the carrier 40, which is used to prevent the carrier 20 sleeved in the outer sleeve 10 from being displaced.

[0062] The carrier 20 is provided with a hard tube 22, which has high hardness and cannot be cut by scissors. The hard tube 22 can be made of metal. When the biological sample on the carrier 40 needs to be taken out, the outer sleeve 10 corresponding to the position of the hard tube 22 is cut, and then the carrier 20 is taken out. Since the outer sleeve 10 is usually made of plastic, it is very easy to cut. Since the outer sleeve 10 corresponding to the position of the hard tube 22 is cut, the carrier 20 will not be damaged, thereby reducing the possibility of damage to the carrier 20 during the process of taking out the carrier 20.

[0063] If the carrier rod 20 is sleeved with the outer sleeve 10, the relative position between the two cannot be stable, or the interference between the carrier rod 40 and the inner wall of the outer sleeve 10 will occur, thereby damaging the biological sample on the carrier rod 40, and even more, the carrier rod 20 will fall off from the outer sleeve 10, so it is necessary to set the structure of the convex strip 23 to stabilize the relative position between the carrier rod 20 and the outer sleeve 10.

[0064] The carrier rod 20 between the hard tube 22 and the carrier rod 40 is provided with an exhaust groove, and the exhaust groove is at least one, and at least part of the gas in the outer sleeve 10 is discharged through the exhaust groove when the carrier rod 20 is sleeved into the outer sleeve 10.

[0065] Since the outer sleeve 10 and the carrier rod 20 are both in an elongated structure, when the carrier rod 20 is sleeved with the outer sleeve 10, the air in the outer sleeve 10 must be discharged during the sleeving process, otherwise due to the effect of pressure difference resistance, it is difficult to completely sleeve the carrier rod 20 into the outer sleeve 10, so it is appropriate to set the structure of the exhaust groove to assist the exhaust.

[0066] As shown in Figure 6 The weight block 30 includes a body 31 with a diameter smaller than the inner diameter of the outer sleeve 10 and a guide table 32 provided at one end of the body 31, and the guide table 32 is in a circular table shape and the diameter decreases away from the body 31, and the minimum diameter of the guide table 32 is smaller than the inner diameter of the outer sleeve 10 and the maximum diameter is greater than the inner diameter of the outer sleeve 10.

[0067] The body 31 of the weight block 30 is provided with at least one annular boss 33, and the diameter of the annular boss 33 is greater than the inner diameter of the outer sleeve 10.

[0068] In order to stabilize the relative position between the weight block 30 and the outer sleeve 10, on the one hand, the weight block 30 can be pre-buried when the outer sleeve 10 is prepared, so that the weight block 30 is integrally injection molded with the outer sleeve 10; on the other hand, the structure of the weight block 30 can be designed, and the structure of the weight block 30 provided in the embodiment utilizes the structure of the guide table 32 to smoothly push the weight block 30 into the outer sleeve 10, and at the same time, since the maximum diameter of the guide table 32 is greater than the inner diameter of the outer sleeve 10, the guide table 32 is tightly fitted with the outer sleeve 10, and at the same time, the weight block 30 is further provided with a plurality of annular bosses 33 with a diameter greater than the inner diameter of the outer sleeve 10, so as to further improve the stability of the relative position between the outer sleeve 10 and the weight block 30, and avoid the displacement of the weight block 30 in the outer sleeve 10 to damage the biological sample on the carrier rod 40.

[0069] The outer sleeve 10 is provided with a guide port 11 at least at one end, and the guide port 11 increases in diameter away from the outer sleeve 10.

[0070] The structure provided with the guide opening 11 reduces the assembly difficulty between the outer sleeve 10 and the carrier rod 20 and the counterweight 30.

[0071] As shown in Figure 8 The hand-held rod 50 further includes an insertion part for inserting into the outer sleeve 10 to install the carrier rod 20 and a hand-held part for an operator to hold, and the diameter of the hand-held part is much larger than the maximum diameter of the guide opening 11.

[0072] In addition, if the outer sleeve 10 is integrally formed with the counterweight 30, the outer sleeve 10 is of a structure with one end open and the other end sealed, after the carrier rod 20 is inserted into the outer sleeve 10, the open end needs to be sealed;

[0073] If the outer sleeve 10 is not integrally formed with the counterweight 30, the outer sleeve 10 is of a structure with both ends open, after the counterweight 30 is inserted into the outer sleeve 10, the open end close to the counterweight 30 is sealed first, and after the carrier rod 20 is inserted into the outer sleeve 10, the other end is sealed.

[0074] In specific use, the counterweight 30 is inserted into the outer sleeve 10 from one end of the outer sleeve 10 to a specified position, and in the process of insertion, the end of the counterweight 30 provided with the guide platform 32 is inserted into the outer sleeve 10 first, and the end of the outer sleeve 10 close to the counterweight 30 is sealed (if the outer sleeve 10 is integrally formed with the counterweight 30, this step is not needed); the processed biological sample is placed in the groove 41, and then the handle 21 is held to insert the carrier rod 20 into the outer sleeve 10 from the other end of the outer sleeve 10, when most of the carrier rod 20 enters the outer sleeve 10, the operator cannot hold the handle 21, the hand-held rod 50 can be used to assist the insertion of the carrier rod 20 to the specified position, in addition, the relevant information of the biological sample carried by the carrier rod 20 can be written on the handle 21, after the carrier rod 20 is inserted, the other end of the outer sleeve 10 is sealed, after the sealing is completed, the end where the counterweight 30 is located is made to face downward, and the closed freezing carrier rod is placed in the freezing liquid for freezing storage; when it is needed to be taken, according to the biological sample information written on the handle 21, the closed freezing carrier rod needed is selected, if the hard tube 22 is not provided, the seal of the closed freezing carrier rod is directly cut open, and the carrier rod 20 is pulled out, if the hard tube 22 is provided, the outer sleeve 10 matched with the position where the hard tube 22 is located is cut off, and the carrier rod 20 is taken out.

Claims

1. A closed-type refrigeration support rod, comprising a hollow outer tube and a support rod sleeved within the outer tube, characterized in that, A counterweight is provided on the outer tube, and the counterweight is located near one end of the outer tube; One end of the carrier rod is fixed with a slide for placing biological samples, and the end of the carrier rod away from the slide is provided with a handle; when the carrier rod is sleeved with the outer tube, the end of the outer tube with a counterweight is close to the end of the carrier rod where the slide is located. The slide has a groove, and the biological sample is placed in the groove; the groove on the slide includes a bottom wall and two side walls on opposite sides of the bottom wall, the distance between the two side walls increases in the direction away from the bottom wall, and the included angle α between the bottom wall and the side wall is in the range of 120°≤α<180°. The bottom wall of the groove is provided with a first hollow part that penetrates the bottom wall, or the two side walls of the groove are provided with a second hollow part, the second hollow parts are provided in pairs and penetrate through their respective side walls; If the outer tube and the counterweight are integrally formed, the outer tube has a structure with one end open and the other end closed. After inserting the load rod into the outer tube, the open end is sealed. If the outer tube and the counterweight are not integrally formed, the outer tube is open at both ends. After inserting the counterweight into the outer tube, first seal the opening near the counterweight. After inserting the support rod into the outer tube, seal the other end.

2. The enclosed refrigeration support rod according to claim 1, characterized in that, The width 'a' of the first hollow part ranges from 0 < a ≤ 100 μm.

3. The enclosed refrigeration support rod according to claim 1, characterized in that, The width b of the second hollow part is in the range of 0 < b ≤ 200 μm.

4. The enclosed refrigeration support rod according to claim 2 or 3, characterized in that, The outer diameter of the slide ranges from 1.2 to 1.6 mm.

5. The enclosed refrigeration support rod according to claim 4, characterized in that, The thickness of the substrate does not exceed 0.28 mm.

6. The enclosed refrigeration support rod according to claim 1, characterized in that, The carrier rod also includes a rigid tube disposed between the handle and the carrier plate. The carrier rod between the rigid tube and the carrier plate / handle is provided with a protrusion, which is used to prevent the carrier rod sleeved in the outer tube from shifting.

7. The enclosed refrigeration support rod according to claim 1 or 6, characterized in that, The carrier rod also includes a rigid tube disposed between the handle and the carrier plate. The carrier rod between the rigid tube and the carrier plate / handle is provided with an exhaust groove. There is at least one exhaust groove. When the carrier rod is fitted into the outer tube, at least part of the gas in the outer tube is discharged through the exhaust groove.

8. The enclosed refrigeration support rod according to claim 1, characterized in that, The counterweight includes a body with a diameter smaller than the inner diameter of the outer tube and a guide platform located at one end of the body. The guide platform is frustum-shaped and its diameter decreases in the direction away from the body. The minimum diameter of the guide platform is smaller than the inner diameter of the outer tube, and the maximum diameter is larger than the inner diameter of the outer tube.

9. The enclosed refrigeration support rod according to claim 8, characterized in that, The counterweight has at least one annular boss on its body, and the diameter of the annular boss is larger than the inner diameter of the outer sleeve.

10. The enclosed refrigeration support rod according to claim 1, characterized in that, It also includes a handheld rod, which includes an extension for installing the carrier rod inside the outer sleeve, and a handheld part for the operator to hold, the diameter of which is much larger than the maximum diameter of the guide opening.

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