A dual-frequency ultrasound penetration enhancement system based on plant ingredients

Abstract

The application provides a double-frequency ultrasonic penetration system based on plant components, belonging to the field of penetration, and the system comprises: a data acquisition module, which is used to acquire a component set, a molecular weight set and a target point depth set of a plant extract to be penetrated; a data processing module, which is used to determine a first ultrasonic frequency and a second ultrasonic frequency according to the molecular weight set, and to calculate a first ultrasonic duty cycle and a second ultrasonic duty cycle according to the target point depth set; the first ultrasonic frequency is greater than the second ultrasonic frequency; an ultrasonic driving module, which is used to control an ultrasonic emission module to emit a first ultrasonic signal to target skin according to the first ultrasonic frequency and the first ultrasonic duty cycle, so that each component penetrates the skin barrier, and to control the ultrasonic emission module to emit a second ultrasonic signal to the target skin according to the second ultrasonic frequency and the second ultrasonic duty cycle, so that each component reaches a subcutaneous target point. The application can make the effective components in the plant extract penetrate the skin barrier and reach the depth of the subcutaneous target point.

Description

Technical Field

[0001] This invention relates to the field of permeation enhancement, and in particular to a dual-frequency ultrasonic permeation enhancement system based on plant components. Background Technology

[0002] In recent years, with the increasing awareness of skincare, plant-based skincare has gained more and more attention in the cosmetics market, with major skincare brands launching a large number of skincare products based on plant ingredients. Compared to chemically synthesized skincare products, plant extracts are healthier, safer, and more effective for skincare and beauty, and are less likely to cause side effects such as allergies. However, plant extracts are characterized by their mixture and large molecular size, making them more difficult to penetrate the skin barrier and reach subcutaneous targets than chemically synthesized products. Methods for enhancing the penetration of skincare ingredients can be divided into two categories: chemical penetration enhancement and physical penetration enhancement.

[0003] Chemical penetration enhancers refer to the addition of penetration enhancers to skincare products. Cosmetic penetration enhancers can be divided into two categories: chemical penetration enhancers and traditional Chinese medicine transdermal penetration enhancers. Among them, chemical penetration enhancers such as azone, organic acids, and surfactants can cause skin irritation if used in large quantities or for prolonged periods. Traditional Chinese medicine transdermal penetration enhancers such as eucalyptus oil, peppermint, and clove have fewer side effects but lower penetration efficiency.

[0004] Physical penetration enhancement refers to using physical technologies such as electricity and sound to promote the introduction and absorption of skincare ingredients. It can be divided into three types: iontophoresis, electroporation, and ultrasound. Iontophoresis uses a continuous low-voltage direct current to apply an electric field to the skin surface. Based on the principle of repulsion between like charges, it exerts a driving force on ions or charged skincare ingredients, promoting their penetration into the subcutaneous layer. Iontophoresis requires the skincare ingredients to be ionized, thus having certain limitations and relatively low penetration efficiency. Electroporation technology involves altering the orientation of lipid molecules in the stratum corneum under the action of a momentary high-voltage pulsed current. This increases the disordered structure of the lipid bilayer, forming hydrophilic pores, thereby improving the permeability of cells and tissue membranes. However, using a momentary high-voltage current to open skin channels is highly irritating and has adverse effects on the skin and the activity of plant-based skincare ingredients. Ultrasonic infusion refers to the use of the cavitation effect of ultrasound waves and the formation of a temporary, reversible transmission channel in the stratum corneum of the skin. Then, the mechanical effect of ultrasound is used to propel skin care ingredients along the direction of sound wave transmission, through the transmission channel, through the stratum corneum, and to the subcutaneous target point. However, one frequency can only open a penetration channel of one size. Since plant skin care ingredients are mixtures, it is impossible to simultaneously promote the penetration of both large and small molecules. Summary of the Invention

[0005] The purpose of this invention is to provide a dual-frequency ultrasound permeation enhancement system based on plant components, which enables the effective components in plant extracts to penetrate the skin barrier and reach the depth of the subcutaneous target site.

[0006] To achieve the above objectives, the present invention provides the following solution:

[0007] A plant-based dual-frequency ultrasonic permeation enhancement system, comprising:

[0008] The data acquisition module is used to acquire the component set, molecular weight set, and target depth set of the plant extract to be penetrated; the component set includes various components in the plant extract to be penetrated, the molecular weight set includes the molecular weight of each component, and the target depth set includes the depth of the subcutaneous target of each component.

[0009] The data processing module, connected to the data acquisition module, is used to determine a first ultrasonic frequency and a second ultrasonic frequency based on the molecular weight set, and to calculate a first ultrasonic duty cycle and a second ultrasonic duty cycle based on the target depth set; the first ultrasonic frequency is greater than the second ultrasonic frequency.

[0010] The ultrasonic emission module comes into contact with the target skin during operation;

[0011] An ultrasound driving module, connected to both the data processing module and the ultrasound transmitting module, is used to control the ultrasound transmitting module to transmit a first ultrasound signal to the target skin according to the first ultrasound frequency and the first ultrasound duty cycle, and to control the ultrasound transmitting module to transmit a second ultrasound signal to the target skin according to the second ultrasound frequency and the second ultrasound duty cycle. The first ultrasound signal is used to generate a cavitation effect on the surface of the target skin, opening the skin barrier and allowing the components of the plant extract to be penetrated to penetrate the skin barrier. The second ultrasound signal is used to generate an acoustic jet inside the target skin, allowing the components of the plant extract to be penetrated through the skin barrier to reach the subcutaneous target point.

[0012] Optionally, the data processing module includes:

[0013] The frequency ratio calculation submodule, connected to the data acquisition module, is used to determine the maximum molecular weight in the molecular weight set and calculate the frequency ratio based on the maximum molecular weight.

[0014] A frequency calculation submodule, connected to the frequency ratio calculation submodule, is used to obtain the first ultrasonic frequency selected by the user, and calculate the second ultrasonic frequency based on the first ultrasonic frequency and the frequency ratio.

[0015] The power difference calculation submodule is connected to the data acquisition module and is used to determine the maximum depth in the target depth set and calculate the power difference based on the maximum depth.

[0016] A power calculation submodule, connected to the power difference calculation submodule, is used to calculate the first ultrasonic power and the second ultrasonic power based on the power difference and the preset total power.

[0017] The duty cycle calculation submodule is connected to the power calculation submodule and is used to calculate the first ultrasound duty cycle and the second ultrasound duty cycle based on the first ultrasound power and the second ultrasound power.

[0018] Optionally, the frequency ratio calculation submodule calculates the frequency ratio using the following formula:

[0019]

[0020] Among them, R fre For frequency ratio, D max D represents the maximum molecular weight. TH The predetermined limiting molecular weight.

[0021] Optionally, the frequency calculation submodule calculates the second ultrasonic frequency using the following formula:

[0022]

[0023] Among them, f L R is the second ultrasonic frequency. fre For frequency ratio, f H f0 is the first ultrasonic frequency, and f0 is the preset fundamental frequency.

[0024] Optionally, the power difference calculation submodule calculates the power difference using the following formula:

[0025]

[0026] Among them, S power For power difference, L max L is the maximum depth. TH For a predetermined limiting depth, S TH The power difference required to introduce the component to the ultimate depth.

[0027] Optionally, the power calculation submodule calculates the first ultrasonic power and the second ultrasonic power using the following formula:

[0028]

[0029] Where P0 is the preset total power, P H P is the first ultrasonic power. L For the second ultrasonic power, S power This is due to the power difference.

[0030] Optionally, the duty cycle calculation submodule calculates the first ultrasound duty cycle and the second ultrasound duty cycle using the following formula:

[0031]

[0032] Among them, T H The first ultrasound duty cycle, T L P represents the second ultrasound duty cycle. H P is the first ultrasonic power. L This is the second ultrasonic power.

[0033] Optionally, the ultrasonic transmitting module includes:

[0034] A first ultrasonic piezoelectric element is connected to the ultrasonic driving module and is used to emit a first ultrasonic signal to the target skin.

[0035] The second ultrasonic piezoelectric element is connected to the ultrasonic drive module and is used to emit a second ultrasonic signal to the target skin.

[0036] Optionally, both the first ultrasonic piezoelectric pad and the second ultrasonic piezoelectric pad are circular ring structures, and the first ultrasonic piezoelectric pad is located inside the ring of the second ultrasonic piezoelectric pad.

[0037] According to specific embodiments provided by the present invention, the present invention discloses the following technical effects:

[0038] This invention calculates the frequency and duty cycle of dual-frequency ultrasound based on the molecular weight of the components in the plant extract to be enhanced and the depth of the subcutaneous target. By emitting high-frequency ultrasound, a sufficiently large channel is opened in the skin barrier, allowing the active ingredients in the plant extract to penetrate the skin barrier. Low-frequency ultrasound generates an acoustic jet, providing a driving force for the active ingredients to reach the depth of the subcutaneous target. Different plant extracts are adapted to different dual-frequency ultrasound parameters, achieving customized dual-frequency ultrasound parameters that can specifically deliver plant extracts with different components. Attached Figure Description

[0039] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0040] Figure 1 This is a schematic diagram of the modules of the plant-based dual-frequency ultrasonic permeation enhancement system of the present invention;

[0041] Figure 2 This is a schematic diagram of an ultrasonic transmitting module;

[0042] Figure 3 This is a schematic diagram of the effect of dual-frequency ultrasound on the skin surface;

[0043] Figure 4 This is a flowchart illustrating the usage of a plant-based dual-frequency ultrasonic permeation enhancement system.

[0044] Symbol explanation:

[0045] Data acquisition module-1, data processing module-2, ultrasonic drive module-3, ultrasonic emission module-4, first ultrasonic piezoelectric element-41, second ultrasonic piezoelectric element-42. Detailed Implementation

[0046] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0047] The purpose of this invention is to provide a dual-frequency ultrasound permeation enhancement system based on plant components. The system calculates the emission parameters of dual-frequency ultrasound based on the molecular weight of the plant components and the subcutaneous target points. By using dual-frequency ultrasound with customized parameters, the skin barrier is opened, and the transdermal absorption rate of the plant component mixture is specifically improved, thus solving the problem that various components in plant extracts have difficulty crossing the skin barrier to reach their respective subcutaneous targets.

[0048] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0049] like Figure 1 As shown, the present invention provides a dual-frequency ultrasonic permeation enhancement system based on plant components, comprising: a data acquisition module 1, a data processing module 2, an ultrasonic emission module 4, and an ultrasonic drive module 3.

[0050] The data acquisition module 1 is used to acquire the component set, molecular weight set, and target depth set of the plant extract to be enhanced for penetration. In this embodiment, the component set, molecular weight set, and target depth set are stored in the memory.

[0051] The component set includes various components in the plant extracts to be penetrated, the molecular weight set includes the molecular weight of each component, and the target depth set includes the depth of the subcutaneous target of each component.

[0052] Data processing module 2 is connected to data acquisition module 1. Data processing module 2 is used to determine a first ultrasonic frequency and a second ultrasonic frequency based on the molecular weight set, and to calculate a first ultrasonic duty cycle and a second ultrasonic duty cycle based on the target depth set. The first ultrasonic frequency is greater than the second ultrasonic frequency. In this embodiment, data processing module 2 is a processor.

[0053] Specifically, data processing module 2 includes: frequency ratio calculation submodule, frequency calculation submodule, power difference calculation submodule, power calculation submodule and duty cycle calculation submodule.

[0054] The frequency ratio calculation submodule is connected to the data acquisition module 1. This submodule is used to determine the maximum molecular weight in the molecular weight set and calculate the frequency ratio based on the maximum molecular weight. Among them, R fre For frequency ratio, D max D represents the maximum molecular weight. TH The predetermined limit molecular weight, i.e. the limit molecular weight that can be effectively introduced, is determined through multiple permeation-enhancing experiments in the early stages.

[0055] This invention calculates the frequency ratio of dual-frequency ultrasound based on the molecular weight of plant components. The frequency ratio of dual-frequency ultrasound affects the transdermal absorption rate of ultrasound-enhanced permeation. The higher the frequency ratio, the larger the size of the skin barrier channels and the more channels are generated.

[0056] The frequency calculation submodule is connected to the frequency ratio calculation submodule. The frequency calculation submodule is used to obtain the first ultrasonic frequency selected by the user, and calculate the second ultrasonic frequency based on the first ultrasonic frequency and the frequency ratio. Among them, f L R is the second ultrasonic frequency. fre For frequency ratio, f H f0 is the first ultrasonic frequency, and f0 is the preset fundamental frequency, i.e., the fundamental frequency of low-frequency ultrasound.

[0057] This invention provides two ultrasonic frequencies for users to choose from: 1MHz and 3MHz. 3MHz is gentler, while 1MHz is more efficient. Users can choose the first ultrasonic frequency according to their needs.

[0058] The power difference calculation submodule is connected to the data acquisition module 1. The power difference calculation submodule is used to determine the maximum depth value in the target depth set and calculate the power difference based on the maximum depth value. Among them, S power For power difference, L max L is the maximum depth. THThe predetermined limit depth, i.e. the limit depth at which effective infiltration can be achieved, was determined through multiple prior infiltration-enhancing experiments. TH The power difference required to deliver the component to the ultimate depth is the power difference of dual-frequency ultrasound.

[0059] This invention calculates the power difference of dual-frequency ultrasound based on the depth of the subcutaneous target point of plant components. The power difference of dual-frequency ultrasound affects the depth of ultrasound penetration. The depth of action of low-frequency ultrasound is deeper. Adjusting the power difference of dual-frequency ultrasound mainly involves adjusting the working time and intensity of low-frequency ultrasound.

[0060] The power calculation submodule is connected to the power difference calculation submodule. The power calculation submodule is used to calculate the first ultrasonic power and the second ultrasonic power based on the power difference and the preset total power. Where P0 is the preset total power, P H P is the first ultrasonic power. L For the second ultrasonic power, S power This is due to the power difference.

[0061] The duty cycle calculation submodule is connected to the power calculation submodule. The duty cycle calculation submodule is used to calculate the first ultrasound duty cycle and the second ultrasound duty cycle based on the first ultrasound power and the second ultrasound power. Among them, T H The first ultrasound duty cycle, T L P represents the second ultrasound duty cycle. H P is the first ultrasonic power. L This is the second ultrasonic power.

[0062] When the ultrasonic emission module 4 is working, it comes into contact with the target skin.

[0063] As a specific implementation method, such as Figure 2 As shown, the ultrasonic transmitting module 4 includes a first ultrasonic piezoelectric element 41 and a second ultrasonic piezoelectric element 42. The first ultrasonic piezoelectric element 41 is connected to the ultrasonic driving module 3 and is used to emit a first ultrasonic signal to the target skin. The second ultrasonic piezoelectric element 42 is connected to the ultrasonic driving module 3 and is used to emit a second ultrasonic signal to the target skin. Both the first ultrasonic piezoelectric element 41 and the second ultrasonic piezoelectric element 42 are annular structures, and the first ultrasonic piezoelectric element 41 is located inside the annulus of the second ultrasonic piezoelectric element 42.

[0064] The ultrasound driving module 3 is connected to the data processing module 2 and the ultrasound transmitting module 4 respectively. The ultrasound driving module 3 is used to control the ultrasound transmitting module 4 to transmit a first ultrasound signal to the target skin according to the first ultrasound frequency and the first ultrasound duty cycle, and to control the ultrasound transmitting module 4 to transmit a second ultrasound signal to the target skin according to the second ultrasound frequency and the second ultrasound duty cycle.

[0065] The first ultrasound signal is used to create a cavitation effect on the surface of the target skin, opening the skin barrier and allowing the components of the plant extract to penetrate the skin barrier.

[0066] The second ultrasound signal is used to generate an acoustic flow within the target skin, allowing the components of the plant extract to penetrate the skin barrier to reach the subcutaneous target. For example... Figure 3 The diagram shows the effect of dual-frequency ultrasound on the skin surface.

[0067] To better understand the solution of this invention, the usage process of the plant-based dual-frequency ultrasonic permeation enhancement system is described below with reference to specific embodiments, such as... Figure 4 As shown.

[0068] Step 1: Store the set of effective components X, the set of molecular weights D of each component, and the set of subcutaneous target depths L of the plant extract to be penetrated into the memory.

[0069] Let the set of effective components in the plant extract to be penetrated be denoted as X = {x1, x2, x3, ..., x}. n ,…,x N}, where N represents the number of types of active ingredients in the plant extract to be enhanced for better penetration, and x n This represents the nth active ingredient.

[0070] The molecular weight set of each component of the plant extract to be enhanced is denoted as D = {d1, d2, d3, ..., d n ,…,d N}, d n This represents the molecular weight of the nth active ingredient.

[0071] The depth set of the subcutaneous target sites of each component of the plant extract to be enhanced is denoted as L={l1,l2,l3,…,l n ,…,l N}, l n This indicates the depth at which the subcutaneous target of the nth active ingredient is located.

[0072] Step 2: The processor reads the data from the memory and calculates the maximum molecular weight D of each component. max =argmaxD.

[0073] Step 3: The processor calculates the frequency ratio of the dual-frequency ultrasound based on the maximum molecular weight.

[0074] Step 4: Obtain the high-frequency ultrasonic frequency (first ultrasonic frequency) selected by the user. The processor calculates the low-frequency ultrasonic frequency (second ultrasonic frequency) based on the high-frequency ultrasonic frequency.

[0075] Step 5: The processor reads the data from the memory and calculates the maximum value L at the depth of the subcutaneous target point for each component. max =argmaxL.

[0076] Step 6: The processor calculates the power difference of the dual-frequency ultrasound based on the maximum depth.

[0077] Step 7: The processor calculates the high-frequency ultrasonic power and the low-frequency ultrasonic power.

[0078] Step 8: The processor allocates the duty cycle of the two types of ultrasound based on the high-frequency ultrasound power and the low-frequency ultrasound power.

[0079] Step 9: The ultrasound drive module drives the ultrasound emission module to emit dual-frequency ultrasound based on parameters such as the dual-frequency ultrasound frequency and duty cycle calculated by the processor. High-frequency ultrasound creates a cavitation effect on the skin surface, opening the skin barrier and allowing the various components of the plant extract to penetrate it. Low-frequency ultrasound creates an acoustic flow within the skin, enabling the components of the plant extract that have passed through the skin barrier to reach the subcutaneous target.

[0080] This invention calculates the emission parameters of dual-frequency ultrasound based on the molecular weight of plant components and the depth of the subcutaneous target point. High-frequency ultrasound with appropriate emission parameters can open a sufficiently large channel in the skin barrier, allowing the effective components in the plant extract to penetrate the skin barrier. Low-frequency parameters with appropriate emission parameters can generate an acoustic jet, which can provide a driving force for the effective components that penetrate the skin barrier, enabling them to reach the depth of the subcutaneous target point.

[0081] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The descriptions of the above embodiments are only for the purpose of helping to understand the system and core ideas of the present invention. Furthermore, those skilled in the art will recognize that, based on the ideas of the present invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A dual-frequency ultrasonic permeation enhancement system based on plant components, characterized in that, The plant-based dual-frequency ultrasonic permeation enhancement system includes: The data acquisition module is used to acquire the component set, molecular weight set, and target depth set of the plant extract to be penetrated; the component set includes various components in the plant extract to be penetrated, the molecular weight set includes the molecular weight of each component, and the target depth set includes the depth of the subcutaneous target of each component. The data processing module, connected to the data acquisition module, is used to determine a first ultrasonic frequency and a second ultrasonic frequency based on the molecular weight set, and to calculate a first ultrasonic duty cycle and a second ultrasonic duty cycle based on the target depth set; the first ultrasonic frequency is greater than the second ultrasonic frequency. The data processing module includes: The frequency ratio calculation submodule, connected to the data acquisition module, is used to determine the maximum molecular weight in the molecular weight set and calculate the frequency ratio based on the maximum molecular weight. ;in, R fre For frequency ratio, D max This represents the maximum molecular weight. D TH The predetermined limiting molecular weight; A frequency calculation submodule, connected to the frequency ratio calculation submodule, is used to obtain the first ultrasonic frequency selected by the user, and calculate the second ultrasonic frequency based on the first ultrasonic frequency and the frequency ratio. The power difference calculation submodule is connected to the data acquisition module and is used to determine the maximum depth in the target depth set and calculate the power difference based on the maximum depth. A power calculation submodule, connected to the power difference calculation submodule, is used to calculate the first ultrasonic power and the second ultrasonic power based on the power difference and the preset total power. The duty cycle calculation submodule is connected to the power calculation submodule and is used to calculate the first ultrasound duty cycle and the second ultrasound duty cycle based on the first ultrasound power and the second ultrasound power. The ultrasonic emission module comes into contact with the target skin during operation; An ultrasound driving module, connected to both the data processing module and the ultrasound transmitting module, is used to control the ultrasound transmitting module to transmit a first ultrasound signal to the target skin according to the first ultrasound frequency and the first ultrasound duty cycle, and to control the ultrasound transmitting module to transmit a second ultrasound signal to the target skin according to the second ultrasound frequency and the second ultrasound duty cycle. The first ultrasound signal is used to generate a cavitation effect on the surface of the target skin, opening the skin barrier and allowing the components of the plant extract to be penetrated to penetrate the skin barrier. The second ultrasound signal is used to generate an acoustic jet inside the target skin, allowing the components of the plant extract to be penetrated through the skin barrier to reach the subcutaneous target point.

2. The plant-based dual-frequency ultrasonic permeation enhancement system according to claim 1, characterized in that, The frequency calculation submodule calculates the second ultrasonic frequency using the following formula: ； in, f L The second ultrasonic frequency, R fre For frequency ratio, f H The first ultrasonic frequency, f 0 represents the preset base frequency.

3. The plant-based dual-frequency ultrasonic permeation enhancement system according to claim 1, characterized in that, The power difference calculation submodule uses the following formula to calculate the power difference: ； in, S power Due to power difference, L max This represents the maximum depth. L TH For a predetermined limit depth, S TH The power difference required to introduce the component to the ultimate depth.

4. The plant-based dual-frequency ultrasonic permeation enhancement system according to claim 1, characterized in that, The power calculation submodule calculates the first ultrasonic power and the second ultrasonic power using the following formula: ； in, P 0 represents the preset total power. P H The first ultrasonic power, P L For the second ultrasonic power, S power This is due to the power difference.

5. The plant-based dual-frequency ultrasonic permeation enhancement system according to claim 1, characterized in that, The duty cycle calculation submodule uses the following formula to calculate the first ultrasound duty cycle and the second ultrasound duty cycle: ； in, T H The first ultrasound duty cycle, T L The second ultrasound duty cycle, P H The first ultrasonic power, P L This is the second ultrasonic power.

6. The plant-based dual-frequency ultrasonic permeation enhancement system according to claim 1, characterized in that, The ultrasonic transmitting module includes: A first ultrasonic piezoelectric element is connected to the ultrasonic driving module and is used to emit a first ultrasonic signal to the target skin. The second ultrasonic piezoelectric element is connected to the ultrasonic drive module and is used to emit a second ultrasonic signal to the target skin.

7. The plant-based dual-frequency ultrasonic permeation enhancement system according to claim 6, characterized in that, Both the first ultrasonic piezoelectric element and the second ultrasonic piezoelectric element are circular ring structures, and the first ultrasonic piezoelectric element is located inside the ring of the second ultrasonic piezoelectric element.

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