A real-time near-infrared light excitation combined with intraoperative optical navigation device

Abstract

This invention discloses a real-time near-infrared light excitation combined with intraoperative optical navigation device, comprising: an OCT imaging system, an ICG-assisted OCT fluorescence imaging system, a data acquisition unit A, a data acquisition unit B, and a display. The OCT imaging system includes: a light source A, an optical fiber coupler A, a sample path interference detection unit, and an optical frequency clock unit. The ICG-assisted OCT fluorescence imaging system includes: a light source B, an additional OCT reference arm, and an additional OCT detection arm. The additional OCT reference arm includes: a dichroic beam splitter, a reflector A, a lens A, a polarization feedback controller, and a reflector B. The additional OCT detection arm includes: a MEMS scanning reflector, a lens B, and an endoscope. This navigation device integrates an optical coherence tomography system, enabling real-time intraoperative tissue biopsy reference, reducing missed diagnoses and misdiagnoses of metastatic lymph nodes caused by relying solely on indocyanine green fluorescence navigation, and improving surgical precision.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a real-time near-infrared light excitation combined with intraoperative optical navigation device. Background Technology

[0002] Existing intraoperative real-time navigation devices cannot perform biopsy while marking and identifying target tissue. When determining the disease status during surgery, additional in vitro biopsy equipment is required, which is time-consuming and requires complete tissue removal, making it difficult to implement minimally invasive and precise intraoperative assessment and operation. Summary of the Invention

[0003] This application provides a real-time near-infrared light excitation combined with intraoperative optical navigation device to achieve the integrated function of tissue marking and biopsy.

[0004] This application provides a real-time near-infrared light excitation combined with intraoperative optical navigation device, including:

[0005] OCT imaging systems include:

[0006] Light source A;

[0007] Fiber optic coupler A is connected to the light source A;

[0008] The sample path interference detection unit includes:

[0009] A circulator, connected to the fiber optic coupler A;

[0010] Fiber optic coupler B is connected to the circulator;

[0011] Balanced detector A is connected to the circulator and the fiber optic coupler B, respectively.

[0012] Optical frequency clock unit, including:

[0013] Fiber optic coupler C is connected to fiber optic coupler A;

[0014] The collimator is connected to the fiber optic coupler C;

[0015] A polarization feedback controller is connected to the fiber optic coupler C;

[0016] Fiber optic coupler D is connected to the collimator and the polarization feedback controller, respectively.

[0017] Balanced detector B is connected to the fiber optic coupler D;

[0018] The ICG-assisted OCT fluorescence imaging system includes:

[0019] Light source B;

[0020] Additional OCT reference arms include:

[0021] A dichroic beam splitter is used to receive the light beam from the light source B;

[0022] Reflector A is used to reflect the light beam transmitted by the dichroic beam splitter;

[0023] Lens A is used to reflect the light beam from the dichroic beam splitter reflected by the mirror A back to the sample;

[0024] A polarization feedback controller is connected to the fiber coupler B;

[0025] A scattering compensation mirror is used to transmit the light beam transmitted by the polarization feedback controller between the reflecting mirror A and the polarization feedback controller;

[0026] Reflector B is disposed on the other side of reflector A relative to the scattering compensation mirror. Reflector B is located in the optical path where the scattering compensation mirror, reflector A, and polarization feedback controller are located.

[0027] Additional OCT detection arm, including:

[0028] MEMS scanning mirror is used to reflect the light beam of the fiber coupler B;

[0029] Lens B is used to reflect the light beam transmitted by the MEMS scanning mirror to the sample;

[0030] An endoscope is arranged side-by-side with lens B, and the endoscope is used to illuminate the sample;

[0031] Data acquisition unit A is connected to the balanced detector A, the balanced detector B, and the endoscopic camera, respectively. Data acquisition unit A is used to receive ICG fluorescence intensity signals.

[0032] A computer is connected to the data acquisition unit A and performs Fourier transform processing on the signal from the data acquisition unit A;

[0033] Data acquisition unit B is used to receive ICG fluorescence signals;

[0034] A display, connected to the computer and the data acquisition unit B, is used to generate fluorescent images.

[0035] The beneficial effects of the above embodiments are as follows:

[0036] 1. To address the lack of sensitivity and specificity of indocyanine green fluorescence in conventional gastrointestinal tumor intraoperative navigation, an integrated optical coherence tomography system is used to enable real-time tissue biopsy reference during surgery, reducing missed diagnoses and misdiagnoses of metastatic lymph nodes caused by relying solely on indocyanine green fluorescence navigation, thus improving surgical precision.

[0037] 2. To address the issue of quantitative indocyanine green fluorescence, intraoperative optical coherence tomography is used to assist in the diagnosis of quantitative indocyanine green in tissues, thereby adjusting the injection concentration and excitation light. This allows for more individualized surgical navigation plans, employing different navigation plans for different patients (e.g., body mass index BMI) or even different surgical areas, thus improving surgical precision.

[0038] 3. To address the issue of defining the precise resection range for gastrointestinal tumors, radical resection surgery for early-stage gastrointestinal tumors involves a wide surgical area and significant surgical trauma. Using optical coherence tomography combined with indocyanine green fluorescence can help locate the resection margins of early-stage gastrointestinal tumors, determine the status of lymph nodes, and thus customize individualized surgical plans, precisely remove lesions, reduce surgical trauma, and improve surgical precision.

[0039] Based on the above embodiments, the embodiments of this application can be further improved as follows:

[0040] In one embodiment of this application: the additional OCT reference arm further includes: a first X-axis reflector, located in the optical path of the dichroic beam splitter and reflector A, for reflecting the light beam reflected by reflector A; and a first Y-axis reflector, located in the optical path of the first X-axis reflector, for reflecting the light beam reflected by the first X-axis reflector.

[0041] In one embodiment of this application: the beneficial effect of this step is that the additional OCT detection arm further includes: a lens C, which is used to transmit the light beam from the fiber coupler B to the MEMS scanning mirror; a second X-axis mirror, which is used to reflect the light beam reflected from the MEMS scanning mirror; and a second Y-axis mirror, which is disposed between the second X-axis mirror and the lens B, and is used to reflect the light beam reflected from the second X-axis mirror. Attached Figure Description

[0042] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the accompanying drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0043] Figure 1 This is a structural diagram of a specific embodiment.

[0044] Among them, 1 is the OCT imaging system, 101 is the light source A, 102 is the fiber optic coupler A, 103 is the sample path interference detection unit, 104 is the optical frequency clock unit, 105 is the fiber optic coupler C, 106 is the collimator, 107 is the polarization feedback controller, 108 is the fiber optic coupler D, and 109 is the balanced detector B.

[0045] 2ICG with OCT fluorescence imaging system, 201 light source B, 202 additional OCT reference arm, 203 additional OCT detection arm, 204 dichroic beam splitter, 205 reflector A, 206 lens A, 207 polarization feedback controller, 208 reflector B, 209 MEMS scanning reflector, 210 lens B, 211 endoscope, 212 first X-axis reflector, 213 first Y-axis reflector, 214 lens C, 215 second X-axis reflector, 216 second Y-axis reflector;

[0046] 3. Data Acquisition Device A;

[0047] 4. Computers;

[0048] 5. Data Acquisition Unit B;

[0049] 6 monitors. Detailed Implementation

[0050] In this application, unless otherwise explicitly specified and limited, terms such as installation, connection, linking, fixing, and fastening should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, in which appropriate connection methods can be selected from existing technologies, such as welding, riveting, threaded connection, bonding, pin connection, key connection, elastic deformation connection, snap-fit ​​connection, interference fit connection, and injection molding to achieve structural connection; they can also refer to an electrical connection, transmitting energy or signals electrically; they can refer to a direct connection or an indirect connection through an intermediate medium, and can refer to the internal communication of two components or the interaction between two components. For those skilled in the art, the specific meaning of the above terms in this invention can be understood according to the specific circumstances.

[0051] like Figure 1As shown, a real-time near-infrared light excitation combined with intraoperative optical navigation device includes: 1. an OCT imaging system, 2. an ICG-assisted OCT fluorescence imaging system, 3. a data acquisition unit A, 4. a data acquisition unit B, and 5. a display. The OCT imaging system includes: 101 a light source A, 102 a fiber optic coupler A, 103 a sample path interference detection unit, and 104 an optical frequency clock unit. Fiber optic coupler A is connected to light source A. The sample path interference detection unit includes: a circulator, a fiber optic coupler B, and a balanced detector A. The circulator is connected to fiber optic coupler A, and fiber optic coupler B is connected to the circulator. The balanced detector A is connected to both the circulator and fiber optic coupler B. The optical frequency clock unit... The clock unit includes: 105 fiber coupler C, 106 collimator, 107 polarization feedback controller, 108 fiber coupler D, and 109 balanced detector B. Fiber coupler C is connected to fiber coupler A, the collimator is connected to fiber coupler C, the polarization feedback controller is connected to fiber coupler C, fiber coupler D is connected to both the collimator and the polarization feedback controller, and the balanced detector B is connected to fiber coupler D. The ICG-assisted OCT fluorescence imaging system includes: 201 light source B, 202 auxiliary OCT reference arm, and 203 auxiliary OCT detection arm. The auxiliary OCT reference arm includes: 204 dichroic beam splitter, 205 mirror A, 206 lens A, and 2... 07 Polarization feedback controller, 208 Reflector B, a dichroic beam splitter for receiving the beam from light source B, reflector A for reflecting the beam transmitted by the dichroic beam splitter, lens A for reflecting the beam from the dichroic beam splitter reflected by reflector A to the sample, polarization feedback controller connected to fiber optic coupler B, scattering compensation mirror for transmitting the beam transmitted by polarization feedback controller between reflector A and polarization feedback controller, reflector B positioned on the opposite side of reflector A relative to scattering compensation mirror, reflector B located in the optical path of scattering compensation mirror, reflector A, and polarization feedback controller, additional OCT detection arm including: 209 MEMS scanning reflector, 210 lens B, 21... 1. An endoscope, a MEMS scanning mirror for reflecting the light beam from fiber optic coupler B, a lens B for reflecting the light beam transmitted by the MEMS scanning mirror to the sample, an endoscope positioned alongside lens B for illuminating the sample, a data acquisition unit A connected to balanced detector A, balanced detector B, and the endoscope, receiving the ICG fluorescence intensity signal generated by the endoscope, a computer connected to data acquisition unit A for performing Fourier transform processing on the signal from data acquisition unit A, data acquisition unit B for receiving the ICG fluorescence signal from the captured sample, and a display connected to the computer and data acquisition unit B for generating fluorescence images.

[0052] Specifically, light source A is a 1310nm swept frequency light source, and light source B is an 850nm light source.

[0053] Specifically, both data acquisition device A and data acquisition device B are data acquisition cards.

[0054] like Figure 1 As shown, the additional OCT reference arm also includes: 211 a first X-axis reflector and 212 a first Y-axis reflector. The first X-axis reflector is located in the optical path of the dichroic beam splitter and reflector A, and is used to reflect the light beam reflected from reflector A. The first Y-axis reflector is located in the optical path of the first X-axis reflector and is used to reflect the light beam reflected from the first X-axis reflector.

[0055] like Figure 1 As shown, the additional OCT detection arm also includes: 213 lens C, 214 second X-axis reflector, and 215 second Y-axis reflector. Lens C is used to transmit the light beam from fiber coupler B to MEMS scanning reflector. The second X-axis reflector is used to reflect the light beam reflected from MEMS scanning reflector. The second Y-axis reflector is disposed between the second X-axis reflector and lens B and is used to reflect the light beam reflected from the second X-axis reflector.

[0056] The operation of this real-time near-infrared light excitation combined with intraoperative optical navigation device is as follows: Light source A generates a light beam, which is then split into two beams via fiber optic coupler A. One beam leads to a circulator, and the other to fiber optic coupler C. The beam passing through fiber optic coupler B is further split into two beams, which pass through a polarization feedback controller and a collimator, respectively. These beams are then converged via fiber optic coupler D and passed through balanced detector B. The beam passing through balanced detector B is acquired by data acquisition unit A. The beam leading to the circulator is then split into two beams, one leading to fiber optic coupler B and the other to balanced detector A. The beam leading to fiber optic coupler B is further split into two beams; one beam passes through balanced detector A and is then acquired by data acquisition unit A. The circulator and fiber optic coupler B together form a sample detection interferogram. The beam is detected by balanced detector A, forming a Fourier domain OCT. Another beam generated by fiber coupler B is simultaneously transmitted to the additional OCT reference arm and the additional OCT detection arm. The beam leading to the additional OCT reference arm passes through a polarization feedback controller, then through a scattering compensation mirror, and is reflected by mirror A to mirror B, and then reflected back to the scattering compensation mirror. The beam leading to the additional OCT detection arm passes through lens C and is directed to the MEMS scanning mirror. After its optical path is changed by the first X-axis mirror and the first Y-axis mirror, it illuminates the sample through lens B. The endoscopic camera transmits the ICG fluorescence intensity signal to data acquisition unit A, which then transmits the acquired signal to a computer. This triggers the MZI detector, which is uniformly spaced at optical frequencies. The zero-crossing discrete data of the stripes undergoes a Fourier transform to generate a sample (line A). The time-domain information is then converted to frequency-domain information via a Fourier transform within the computer. The computer directly processes the data to generate a tomographic image and transmits it to the display. Light source B generates a beam, which is then separated into a specific spectrum by a dichroic mirror before being directed towards mirror A. Mirror A reflects the beam sequentially through a second X-axis mirror and a second Y-axis mirror before directing it towards lens A. Lens A directs the beam towards the sample. Data acquisition device B acquires the ICG fluorescence signal formed by this beam and transmits it to the display. The frequency-sweeping light source of OCT is used to detect the ICG fluorescence intensity in the tissue. Based on empirical fluorescence intensity and ICG concentration, the optimal ICG injection concentration for tumor margins and lymph node tracing at different locations is determined.

[0057] The above are merely embodiments of the present invention. Commonly known structures and characteristics of the solutions are not described in detail here. Those skilled in the art are aware of all common technical knowledge in the field prior to the application date or priority date, are aware of all existing technologies in that field, and have the ability to apply conventional experimental methods prior to that date. Those skilled in the art can, based on the guidance provided in this application, improve and implement this solution in combination with their own capabilities. Some typical known structures or methods should not be obstacles for those skilled in the art to implement this application. It should be noted that those skilled in the art can make several modifications and improvements without departing from the structure of the present invention. These should also be considered within the scope of protection of the present invention, and will not affect the effectiveness of the implementation of the present invention or the practicality of the patent.

Claims

1. A real-time near-infrared light excitation combined with intraoperative optical navigation device, characterized in that, include: OCT imaging systems include: Light source A; Fiber optic coupler A is connected to the light source A; The sample path interference detection unit includes: A circulator, connected to the fiber optic coupler A; Fiber optic coupler B is connected to the circulator; Balanced detector A is connected to the circulator and the fiber optic coupler B, respectively. Optical frequency clock unit, including: Fiber optic coupler C is connected to fiber optic coupler A; The collimator is connected to the fiber optic coupler C; A polarization feedback controller is connected to the fiber optic coupler C; Fiber optic coupler D is connected to the collimator and the polarization feedback controller, respectively. Balanced detector B is connected to the fiber optic coupler D; The ICG-assisted OCT fluorescence imaging system includes: Light source B; Additional OCT reference arms include: A dichroic beam splitter is used to receive the light beam from the light source B; Reflector A is used to reflect the light beam transmitted by the dichroic beam splitter; Lens A is used to reflect the light beam from the dichroic beam splitter reflected by the mirror A back to the sample; A polarization feedback controller is connected to the fiber coupler B; A scattering compensation mirror is used to transmit the light beam transmitted by the polarization feedback controller between the reflecting mirror A and the polarization feedback controller; Reflector B is disposed on the other side of reflector A relative to the scattering compensation mirror. Reflector B is located in the optical path where the scattering compensation mirror, reflector A, and polarization feedback controller are located. Additional OCT detection arm, including: MEMS scanning mirror is used to reflect the light beam of the fiber coupler B; Lens B is used to reflect the light beam transmitted by the MEMS scanning mirror to the sample; An endoscope is arranged side-by-side with lens B, and the endoscope is used to illuminate the sample; Data acquisition unit A is connected to the balanced detector A, the balanced detector B, and the endoscopic camera, respectively. Data acquisition unit A is used to receive ICG fluorescence intensity signals. A computer is connected to the data acquisition unit A and performs Fourier transform processing on the signal from the data acquisition unit A; Data acquisition unit B is used to receive ICG fluorescence signals; A display, connected to the computer and the data acquisition unit B, is used to generate fluorescent images; Light source A generates a light beam, which is then split into two beams via fiber coupler A. One beam leads to a circulator, and the other to fiber coupler C. The beam passing through fiber coupler C is further split into two paths, passing through a polarization feedback controller and a collimator respectively. These paths are then converged via fiber coupler D and pass through balanced detector B. The beam passing through balanced detector B is acquired by data acquisition unit A. The beam leading to the circulator is then split into two paths, one leading to fiber coupler B and the other to balanced detector A. The beam leading to fiber coupler B is further split into two paths; one path passes through balanced detector A and is acquired by data acquisition unit A. The circulator and fiber coupler B together form a sample detection interferogram, which is then detected by balanced detector A, constituting a Fourier transform. The optical fiber coupler B generates another beam that is simultaneously transmitted to the additional OCT reference arm and the additional OCT detection arm. The beam leading to the additional OCT reference arm passes through a polarization feedback controller, then through a scattering compensation mirror, and is reflected by mirror A to mirror B. Mirror B then reflects the beam back to the scattering compensation mirror. The beam leading to the additional OCT detection arm passes through lens C and is directed to the MEMS scanning mirror. After its optical path is altered by the first X-axis and first Y-axis mirrors, it illuminates the sample through lens B. The endoscopic camera transmits the ICG fluorescence intensity signal to data acquisition unit A, which then transmits the acquired signal to a computer. This triggers the MZI detector, which is uniformly spaced at optical frequencies. The zero-crossing discrete data of the stripes undergoes a Fourier transform to generate samples. The time-domain information is then converted to frequency-domain information via a Fourier transform within the computer. The computer directly processes the data to generate a tomographic image and transmits it to the display. Light source B generates a beam, which is then separated into a specific spectrum by a dichroic mirror before being directed towards mirror A. Mirror A reflects the beam sequentially through a second X-axis mirror and a second Y-axis mirror before directing it towards lens A. Lens A directs the beam towards the sample. Data acquisition device B acquires the ICG fluorescence signal formed by this beam and transmits it to the display. The frequency-sweeping light source of OCT is used to detect the ICG fluorescence intensity in the tissue, and the fluorescence intensity is fitted to the ICG concentration.

2. The real-time near-infrared light excitation combined with intraoperative optical navigation device according to claim 1, characterized in that, The additional OCT reference arm also includes: The first X-axis reflector is located in the optical path of the dichroic beam splitter and reflector A, and is used to reflect the light beam reflected from reflector A. The first Y-axis reflector is located in the optical path of the first X-axis reflector and is used to reflect the light beam reflected from the first X-axis reflector.

3. The real-time near-infrared light excitation combined with intraoperative optical navigation device according to claim 1, characterized in that, The additional OCT detection arm also includes: Lens C, which is used to transmit the light beam from the fiber optic coupler B to the MEMS scanning mirror; The second X-axis reflector is used to reflect the light beam reflected from the MEMS scanning reflector. The second Y-axis reflector is disposed between the second X-axis reflector and the lens B. The second Y-axis reflector is used to reflect the light beam reflected by the second X-axis reflector.

Images