A portable detection device for measuring the biomagnetic field of laboratory animals

Abstract

The application discloses a movable detection device for measuring the biomagnetic field of experimental animals, and belongs to the field of biomagnetic field measurement. The movable operation platform can be transferred between different laboratories, and different experiments can be efficiently and continuously carried out. The biomagnetic field measurement device can adjust the height of the probe, adjust the horizontal position of the probe through the square hole array, and measure the spatial distribution of the biomagnetic field of the experimental animals. The device is suitable for measuring the biomagnetic field generated by different experimental animals, and is convenient for transferring, fixing and detecting the experimental animals.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of biological magnetic field measurement, and particularly relates to a movable detection device for measuring biological magnetic field of experimental animals. BACKGROUND

[0002] The measurement of biological magnetic field of experimental animals has important value in clinical and scientific research applications. Researchers can study the physiological mechanisms of the generation and dynamics of electromagnetic field in the living body by measuring the time and spatial variation of the biological magnetic field; researchers can study the methods of identifying and predicting diseases through magnetocardiogram and magnetocardiogram curve to guide clinical diagnosis by analyzing the relationship between the biological magnetic field and pathological characteristics; researchers can carry out deeper experimental research by combining the measurement of biological magnetic field with other measurements such as electrocardiogram.

[0003] In order to measure the biological magnetic field of experimental animals, researchers at home and abroad have designed and prepared different experimental animal magnetic field measurement devices, such as superconducting quantum interference devices and atomic magnetometers. The existing experimental animal biological magnetic field measurement means focuses on measuring in a fixed shielding barrel or shielding chamber, and the experimental animals may be transferred many times during measurement, and the movement or stress during the transfer process may affect the physiological condition of the experimental animals and affect the accuracy of the experimental results. The existing measurement instruments do not take into account the characteristics that experimental animals cannot cooperate with instructions, which increases the difficulty of measurement operation. The existing magnetic field measurement devices are limited by the number and volume of measurement instruments, and are not convenient for measuring the spatial distribution of the biological magnetic field of experimental animals. Therefore, the existing measurement means is not suitable for measuring experimental animals between continuously carried out multiple experiments. SUMMARY

[0004] In view of the above-mentioned deficiencies of the existing experimental animal biological magnetic field measurement means, the present application provides a movable detection device for measuring the biological magnetic field of experimental animals. The device has strong versatility and is suitable for measuring the magnetic field generated by different experimental animals, and is convenient for fixing experimental animals and detection. The device takes into account the transfer and operation requirements between different types of measurement, and is convenient for joint and continuous development with other measurements. The device takes into account the number and volume limitations of the probe and the requirements for measuring the spatial distribution of the biological magnetic field of experimental animals, and uses a probe array to detect the biological magnetic field of experimental animals.

[0005] The technical solutions adopted by the present application are as follows:

[0006] A movable detection device for measuring the biological magnetic field of experimental animals, comprising: a movable operation platform (100), a magnetic shielding device (200), an experimental animal fixing device (300) and a biological magnetic field measurement device (400); wherein,

[0007] The magnetic shielding device (200) comprises a magnetic shielding barrel (210) and a barrel cover (220), the barrel cover (220) is detachably covered on the barrel opening of the magnetic shielding barrel (210), and the magnetic shielding barrel (210) is fixedly installed on the movable operation platform (100).

[0008] The experimental animal fixing device (300) comprises a base (310) and a movable part (320), the base (310) is detachably arranged in the magnetic shielding barrel (210).

[0009] The base (310) is barrel-shaped, and an upper layer flat plate (312) and a lower layer flat plate (313) are arranged in the base (310) in a transverse parallel mode, and a through window (311) is arranged on the top of the base (310).

[0010] The upper layer flat plate (312) is provided with a through square hole (314), and the square hole (314) is vertically opposite to the window (311).

[0011] The front and rear edges of the square hole (314) are provided with two vertically parallel vertical plates (315), and a plurality of horizontal row screw holes (316) are arranged on the vertical plates (315).

[0012] The movable part (320) comprises a fixed plate (321), a vertical column (323) and two convex strips (324), the fixed plate (321) is arranged in a transverse mode, the vertical column (323) is vertically fixed on the fixed plate (321), the two convex strips (324) are arranged on the two sides of the fixed plate (321), and a horizontal row small hole (325) is arranged on each of the two convex strips (324); the movable part (320) is placed on the lower layer flat plate (313) and vertically opposite to the square hole (314) of the upper layer flat plate (312).

[0013] The biological magnetic field measuring device (400) comprises a probe box (410) and a plurality of probes, the bottom of the probe box (410) is provided with a square hole array (411), and the probes are detachably placed in the square holes; and the probe box (410) is detachably fixed on the square hole (314) of the upper layer flat plate (312).

[0014] Preferably, the movable operation platform (100) comprises a box type frame (110), and the box type frame (110) comprises two layers of spaced spaces.

[0015] Preferably, the movable operation platform (100) further comprises a plurality of platforms (120) and a plurality of foldable triangular supports (130), each of the platforms (120) is pivotally connected to the top and / or bottom of the side of the box-shaped frame (110) through two of the foldable triangular supports (130); the platform (120) is closed on the side of the box-shaped frame (110) when it is folded, and is laterally extended outward when it is unfolded.

[0016] Preferably, the movable operation platform (100) further comprises a plurality of barrel supports (140), the barrel supports (140) are fixed to the top of the box-shaped frame (110); the top of the barrel support (140) is in the shape of a concave arc, used for supporting and fixing the magnetic shielding barrel (210) of the magnetic shielding device (200).

[0017] Preferably, the movable operation platform (100) further comprises a plurality of pairs of wheels (150), the wheels (150) are installed around the bottom of the box-shaped frame (110).

[0018] Preferably, the magnetic shielding barrel (210) is a multi-layer barrel structure made of high permeability alloy, and the barrel cover (220) is made of multi-layer alloy.

[0019] Preferably, the top of the small hole (325) of the convex strip (324) is provided with an axial gap (326) penetrating the top wall of the small hole (325).

[0020] Preferably, the vertical column (323) is provided with a plurality of longitudinal grooves.

[0021] Preferably, the movable part (320) further comprises a vertical plate structure (322), the bottom of the vertical plate structure (322) is fixed to the end of the fixed plate (321), the top of the vertical plate structure (322) is horizontally flush, the two sides are symmetrical arc-shaped, and the arc-shaped side plates extending beyond the inner side are connected; the end of the fixed plate (321) refers to the end of the fixed plate (321) close to the bottom of the base (310); the vertical column (323) is located at the end of the fixed plate (321) and the inner side of the vertical plate structure (322).

[0022] Preferably, the probe box (410) is detachably fixed to the square hole (314) of the upper layer plate (312) through the screw hole (316) of the vertical plate (315) of the upper layer plate (312) without screwing.

[0023] The movable detection device for measuring the biomagnetic field of experimental animals has the following advantages:

[0024] (1) The traditional experimental animal biomagnetic field measuring device cannot be moved between different experimental sites, cannot exclude the influence on the experimental animals during the transfer process, thereby affecting the accuracy of the experimental results, and is not conducive to the continuous and joint development of multiple experiments. The movable detection device adopted in the present application comprehensively considers the biological laboratory environment and demand, sets a movable operation platform, can be transferred between different laboratories, and can efficiently and continuously carry out different experiments.

[0025] (2) The traditional experimental animal biomagnetic field measuring device cannot conveniently move and fix the position of the probe, cannot adjust the height of the probe for the experimental animals, and cannot measure the spatial distribution of the experimental animal biomagnetic field when the number of probes is small. The experimental animal biomagnetic field measuring device adopted in the present application considers the limitations and measurement requirements of the measuring instrument, can adjust the height of the probe, adjusts the horizontal position of the probe through the square hole array, and measures the spatial distribution of the experimental animal biomagnetic field. When the number of probes is small, the biomagnetic field at different positions can be measured in sequence, and when the number of probes is large, the biomagnetic field at each position can be measured simultaneously, which can be flexibly used in different situations. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figures 1A-1C is a structural schematic diagram of the movable detection device in the embodiment.

[0027] Figures 2A-2C is a structural schematic diagram of the unfolded platform of the movable detection device in the embodiment.

[0028] Figures 3A-3C is a structural schematic diagram of the base of the experimental animal fixing device.

[0029] Figures 4A-4B is a specific structural schematic diagram of the upper plate of the base.

[0030] Figures 5A-5C is a structural schematic diagram of the movable part.

[0031] Figures 6A-6B is a structural schematic diagram of the probe box.

[0032] Figure 7 is a schematic diagram of the probe box placed in the base.

[0033] BRIEF DESCRIPTION OF DRAWINGS:

[0034] 100: movable operation platform;

[0035] 110: box frame;

[0036] 120: platform;

[0037] 130: foldable triangular support;

[0038] 140: barrel support;

[0039] 150: wheel;

[0040] 200: magnetic shielding device;

[0041] 210: magnetic shielding barrel;

[0042] 220: barrel cover;

[0043] 300: experimental animal fixing device;

[0044] 310: base;

[0045] 311: window;

[0046] 312: upper flat plate;

[0047] 313: lower flat plate;

[0048] 314: square hole;

[0049] 315: vertical plate;

[0050] 316: screw hole;

[0051] 320: movable part;

[0052] 321: fixed plate;

[0053] 322: vertical plate structure;

[0054] 323: vertical column;

[0055] 324: convex strip;

[0056] 325: small hole;

[0057] 326: slit;

[0058] 400: biological magnetic field measuring device;

[0059] 410: probe box;

[0060] 411: square hole array. DETAILED DESCRIPTION

[0061] In order to make the above features and advantages of the present application more obvious and easy to understand, the following specific embodiments are described in detail below, with reference to the accompanying drawings.

[0062] Reference Figures 1A-1C , the embodiment specifically discloses a movable detection device for measuring the biological magnetic field of an experimental animal, which comprises a magnetic shielding device 200, a movable operation platform 100, an experimental animal fixing device 300 and a biological magnetic field measuring device for experimental animals.

[0063] ReferenceFigures 2A-2C The movable operation platform 100 uses alloy material to make the box frame 110 structure, which is divided into two layers of space separated by the upper and lower, and each layer of space can be placed in the goods. The top of the box frame 110 is provided with a group of barrel supports 140 to support the magnetic shielding device 200. The movable operation platform 100 is installed with wheels 150 to move the whole device. The movable operation platform 100 is installed with a platform on the four sides of the box frame 110, respectively, each of the platform 120 and the box frame 110 are connected by foldable triangular supports 130 and can be folded and unfolded, and after unfolding, it is transverse and can be used as a platform for placing lighter goods and experimental operation.

[0064] Referring to Figure 1A The magnetic shielding device 200 uses a multi-layer magnetic shielding barrel 210 made of high magnetic permeability alloy. One end of the magnetic shielding device 200 is an openable multi-layer alloy barrel cover 220, which facilitates the placement of experimental devices in the barrel and the closure of the barrel space.

[0065] The experimental animal fixing device 300 uses a special shape made of non-magnetic material to fix and move experimental animals, including a base 310 and a movable part 320. Referring to Figures 3A-3C The base 310 is barrel-shaped or hollow cylindrical, and its outer diameter is slightly smaller than the inner diameter of the shielding barrel of the magnetic shielding device 200. The base 310 can be stably placed inside the magnetic shielding device 200. The hollow part inside the base 310 is divided into three parts by the transverse upper plate 312 and the lower plate. Referring to Figures 4A-4B A square hole is opened in the center of the upper plate, and a vertical plate 315 is arranged on the front and rear sides of the square hole 314, respectively. The vertical plate 315 is provided with two rows of screw holes, which can be used to fix the biological magnetic field measuring device.

[0066] Referring to Figures 5A-5C The main body of the movable part 320 is a fixed plate 321, and the fixed plate 321 is provided at the end with a vertical plate structure 322. The shape of the vertical plate structure 322 is as Figure 5A, the top is transverse flat, the two sides are symmetrical circular arc shape, and the circular arc side plate is connected with the super-inboard extension. The vertical plate structure 322 can be naturally placed in the upper area of the lower layer flat plate 313 of the base 310, and can be slid in a hand pushing manner. The two sides of the fixed plate 321 of the movable part are each provided with a convex strip 324, which is a long strip-shaped convex, and a row of small holes 325 is arranged on the convex strip. Each small hole 325 is provided with a gap 326 at the edge, so that the surgical thread can pass through and bind. A stand 323 is arranged at the center of the end of the fixed plate 321, and the stand 323 contains a plurality of grooves, and the surgical thread can be bound in the grooves. When the experimental animal is fixed by using the movable part 320, the experimental animal can be placed in a flat lying state on the fixed plate 321, the head is towards the stand 323, one end of the surgical thread is bound on the stand 323, and the other end is bound on the teeth of the animal, so as to fix the head; at the same time, one end of the surgical thread is bound on the limbs, and the other end is bound on the small holes 325 of the convex strips 324 on the two sides, so as to fix the limbs.

[0067] The biological magnetic field measuring device 400 includes a probe and a probe box 410, and the biological magnetic field measuring device uses the probe such as a magnetometer probe to form an array to measure the biological magnetic field of the experimental animal. Referring to Figures 6A-6B , the bottom surface of the probe box 410 is provided with a through array of square holes, and the size of each square hole is equal to the size of the bottom surface of the probe. The probe can be inserted into the square hole and fixed in the probe box 410. One probe inserted into different square holes can measure the magnetic field at different positions at the same horizontal height in turn. Multiple probes inserted into multiple square holes can form a probe array to simultaneously measure the distribution of the biological magnetic field of the experimental animal in space. Figure 7 is a schematic view of the probe box 410 of the biological magnetic field measuring device 400 fixed on the base 310 of the experimental animal fixing device 300. The size of the bottom surface of the probe box 410 is equal to the size of the square hole 314 in the middle of the upper layer flat plate 312 of the base 310 of the experimental animal fixing device 300. The probe box 410 can be put into the base 310 from above the base 310 through the window 311. Multiple non-magnetic screws are used to pass through the screw holes on the vertical plates 315 on the two sides of the square hole 314, and the frictional force generated by the screws extruding the side surface of the probe box 410 is used to fix the probe box 410 at different heights to meet the needs of measuring the biological magnetic field of experimental animals of different sizes.

[0068] The following provides a specific operation example:

[0069] In this example, domestic rabbits are used as experimental animals to be measured, and the device of the application is used to measure the distribution of the biological magnetic field of the domestic rabbits at different positions on the horizontal surface of the body surface by using a QuSpin probe.

[0070] When measuring, the limbs of the rabbit are fixed on the small holes of the convexity on both sides of the movable part by surgical thread, and the head is fixed on the stand by surgical thread. Then the movable part is put into the base of the experimental animal fixing device, and the depth is adjusted so that the rabbit is located directly below the probe.

[0071] First, the probe is fixed into the square hole of the first row of the first column at the bottom of the probe box, the probe box is put into the base from the square hole at the top of the experimental animal fixing device, and is fixed on the vertical plates beside the square hole by screws, and the height is adjusted so that the probe is as close as possible to the surface of the rabbit to an appropriate distance. After the measurement is completed, the probe is fixed into the square hole of the second row of the first column at the bottom of the probe box, and the measurement is repeated. In this way, the biomagnetic field of the rabbit at the corresponding positions of all the square holes is measured.

[0072] Although the present application has been disclosed as above with examples, it is not intended to limit the present application, and any proper modification or equivalent replacement of the technical solutions of the present application made by those skilled in the art shall be covered by the protection scope of the present application, and the protection scope of the present application is defined by the claims.

Claims

1. A portable detection device for measuring the biomagnetic field of laboratory animals, characterized in that, include: A mobile operating platform (100), a magnetic shielding device (200), an experimental animal fixation device (300), and a biomagnetic field measuring device (400); wherein, The magnetic shielding device (200) includes a magnetic shielding barrel (210) and a barrel cover (220). The barrel cover (220) is detachably fitted onto the opening of the magnetic shielding barrel (210). The magnetic shielding barrel (210) is fixedly installed on the movable operating platform (100). The experimental animal fixation device (300) includes a base (310) and a movable part (320), wherein the base (310) is detachably disposed inside the magnetic shielding barrel (210); The base (310) is barrel-shaped. Inside the base (310) are a horizontally parallel upper plate (312) and a lower plate (313). The top of the base (310) is provided with a through window (311). The upper plate (312) is provided with a through square hole (314), which is vertically facing the window (311). The front and rear edges of the square hole (314) are provided with two vertically parallel vertical plates (315), and the vertical plates (315) are provided with several horizontally arranged screw holes (316). The movable component (320) includes a fixed plate (321), a column (323), and two protruding strips (324). The fixed plate (321) is arranged horizontally, and the column (323) is vertically fixed to the fixed plate (321). The two protruding strips (324) are arranged on both sides of the fixed plate (321), and each of the two protruding strips (324) is provided with a horizontal row of small holes (325). The movable component (320) is placed on the lower plate (313) and is vertically aligned with the square hole (314) of the upper plate (312). The top of the horizontal row of small holes (325) of the two protruding strips (324) is provided with an axially oriented slit (326). 26) The top wall of the horizontal row of small holes (325) is penetrated; the column (323) is provided with a plurality of grooves arranged longitudinally; the movable part (320) also includes a vertical plate structure (322), the bottom of the vertical plate structure (322) is fixed to the end of the fixed plate (321), the top of the vertical plate structure (322) is horizontally flush, the two sides are symmetrical arcs, and are connected with arc-shaped side plates protruding outwards; the end of the fixed plate (321) refers to the end of the fixed plate (321) near the bottom of the base (310); the column (323) is located at the end of the fixed plate (321) and is located inside the vertical plate structure (322); The biomagnetic field measuring device (400) includes a probe box (410) and several probes. The bottom of the probe box (410) is provided with a square hole array (411), and the probes can be detachably placed in the square holes. The probe box (410) can be detachably fixed to the square hole (314) of the upper plate (312).

2. The mobile detection device as described in claim 1, characterized in that, The mobile operating platform (100) includes a box frame (110) which includes two separate spaces.

3. The mobile detection device as described in claim 2, characterized in that, The movable operating platform (100) also includes several platform plates (120) and several foldable triangular supports (130). Each platform plate (120) is pivotally connected to the top and / or bottom of the side of the box frame (110) via two foldable triangular supports (130). When the platform plate (120) is closed, it is closed on the side of the box frame (110), and when it is unfolded, it extends laterally outward.

4. The mobile detection device as described in claim 2, characterized in that, The movable operating platform (100) also includes a set of barrel supports (140), which are fixed to the top of the box frame (110); the top of the set of barrel supports (140) is a concave arc shape, which is used to support and fix the magnetic shielding barrel (210) of the magnetic shielding device (200).

5. The mobile detection device as described in claim 2, characterized in that, The movable operating platform (100) also includes several pairs of wheels (150), which are mounted around the bottom of the box frame (110).

6. The mobile detection device as described in claim 1, characterized in that, The magnetic shielding barrel (210) is a multi-layered barrel structure made of a high magnetic permeability alloy, and the barrel lid (220) is made of a multi-layered alloy.

7. The mobile detection device as described in claim 1, characterized in that, The probe box (410) is screwed into the horizontal row of screw holes (316) of the vertical plate (315) of the upper plate (312) by non-magnetic screws.

Images