A compound Chinese medicine composition for treating osteoporosis and its preparation method

Abstract

The invention discloses a compound Chinese medicine composition for treating osteoporosis and a preparation method thereof, and belongs to the technical field of Chinese medicine. The compound Chinese medicine composition of the present invention contains 50-150 weight portions of Epimedium, 30-120 weight portions of Deer Horn Glue, 30-100 weight portions of Octopus mulberry, 50-100 weight portions of Cistanche deserticola, 25-80 weight portions of Cnidium monnieri, 30-100 weight portions of Dipsacus asper, 30-80 weight portions of Rubus idaeus, 10-50 weight portions of Plantago, 30-100 weight portions of Coriolus versicolor, 30-80 weight portions of Lycium barbarum, and 30-80 weight portions of Dioscorea opposita. The compound Chinese medicine composition of the present invention is mainly based on warming and tonifying kidney yang, strengthening tendons and bones, and has the effects of promoting diuresis and removing dampness, invigorating qi and nourishing blood, and can be used for the card of osteoporosis, and the clinical treatment of osteoporosis has an effective rate of up to 93.3%.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a compound traditional Chinese medicine composition for treating osteoporosis and a preparation method thereof. Background Art

[0002] Osteoporosis (OP) is a common systemic metabolic bone disease characterized by decreased bone mass per unit volume and changes in bone microstructure. It is more common in postmenopausal women and elderly men.

[0003] Osteoporosis can be divided into three types according to its etiology: primary, secondary, and idiopathic. Primary osteoporosis includes senile osteoporosis and postmenopausal osteoporosis in women; secondary osteoporosis is closely related to heredity, endocrine system, liver and kidney function, etc. There are many pathogenesis of osteoporosis. At present, there are generally defects in bone absorption and bone formation during bone metabolism caused by long-term strain, living habits, stress, estrogen secretion disorders, and bone aging. A detailed DXA bone density examination is required to confirm osteoporosis. A detailed test of the axial bones (lumbar spine, hip joint) is required for diagnosis (T<=2.5SD); only the wrists and feet are tested during the initial screening. In traditional Chinese medicine, it is generally believed that "the kidney is the innate foundation, and the spleen is the acquired foundation". The two are interdependent and influence each other. The Suwen Wei Lun states: "When kidney qi is hot, the waist and spine cannot be lifted, the bones wither and the marrow decreases, and bone atrophy occurs." The kidney stores essence and produces marrow, the spleen is responsible for development and growth, and the marrow nourishes the bones. Kidney deficiency, spleen deficiency, and stagnant liver qi can all lead to osteoporosis. Blood stasis can also cause osteoporosis.

[0004] Traditional Chinese medicine believes that kidney deficiency is an important cause of osteoporosis. Elderly patients with kidney essence deficiency are more susceptible to osteoporosis than healthy elderly people of the same age. Modern medicine has found that Chinese medicine can play an important role in preventing and treating osteoporosis by regulating immune response, defense response, chemokines, and signal transduction pathways. The liver and kidney are closely related. When the liver and kidney are integrated and nourish each other, the kidney essence is abundant, the liver blood is abundant, and the muscles and bones are strong. Many studies have shown that traditional Chinese medicine can significantly improve bone density and bone strength by nourishing the liver and kidney, and improve the microstructure of bones, thereby treating osteoporosis. Summary of the invention

[0005] The main purpose of the present invention is to provide a compound Chinese medicine composition for treating osteoporosis. The prescription is mainly based on warming and tonifying kidney yang, strengthening tendons and bones, and has the effects of promoting diuresis and removing dampness, invigorating qi and nourishing blood, and can be used for osteoporosis.

[0006] To achieve the above objectives, the present invention adopts the following technical solutions:

[0007] A Chinese medicine composition comprising the following components:

[0008] 50-150 parts by weight of epimedium, 30-120 parts by weight of antler glue, 30-100 parts by weight of silkworm cocoon, 50-100 parts by weight of Cistanche deserticola, 25-80 parts by weight of Cnidium monnieri, 30-100 parts by weight of Dipsacus asper, 30-80 parts by weight of Rubus idaeus, 10-50 parts by weight of Plantago, 30-100 parts by weight of Coriolus versicolor, 30-80 parts by weight of Lycium barbarum, and 30-80 parts by weight of Dioscorea opposita;

[0009] Furthermore, the above-mentioned Chinese medicine composition contains the following components:

[0010] 80-120 parts by weight of epimedium, 50-100 parts by weight of antler glue, 60-90 parts by weight of silkworm cocoon, 60-80 parts by weight of Cistanche deserticola, 40-60 parts by weight of Cnidium monnieri, 50-70 parts by weight of Dipsacus asper, 50-60 parts by weight of Rubus idaeus, 20-35 parts by weight of Plantago, 50-80 parts by weight of Versicolor, 50-70 parts by weight of Lycium barbarum, and 40-60 parts by weight of Dioscorea opposita.

[0011] Furthermore, the above-mentioned Chinese medicine composition also contains the following components:

[0012] 20-100 parts by weight of Eclipta prostrata, 30-100 parts by weight of Viscum album, 20-80 parts by weight of Astragalus membranaceus, and 20-100 parts by weight of Jerusalem artichoke;

[0013] Furthermore, the above-mentioned Chinese medicine composition also contains the following components:

[0014] 50-80 parts by weight of Eclipta prostrata, 50-70 parts by weight of Viscum album, 30-50 parts by weight of Astragalus membranaceus, and 50-80 parts by weight of Jerusalem artichoke.

[0015] The second object of the present invention is to provide the use of the above-mentioned Chinese medicine composition in the preparation of drugs for treating osteoporosis.

[0016] The third object of the present invention is to provide a Chinese medicine preparation for treating osteoporosis, wherein the Chinese medicine preparation is prepared from the above-mentioned Chinese medicine composition.

[0017] The Chinese medicine preparations described above may be clinically acceptable oral solid preparations or liquid preparations; the oral solid preparations include but are not limited to capsules, tablets, granules, etc., and the oral liquid preparations include but are not limited to oral liquids, syrups, etc.

[0018] The invention also provides a preparation method of the above-mentioned traditional Chinese medicine preparation, comprising the following steps: crushing antler glue into antler glue fine powder for standby use; refluxing and extracting epimedium, mulberry silkworm sheath, cnidium monnieri, dipsaccharum officinale, mistletoe and Eclipta prostrata with an ethanol solution with a volume fraction of 50-70% to obtain an extract for standby use; adding 5-10 times the amount of water to decoct Cistanche deserticola, raspberry, plantago seed, versicolor, wolfberry, yam, astragalus and Jerusalem artichoke, and using the decoction for standby use; combining the obtained extract and decoction, concentrating, adding antler glue fine powder and conventional auxiliary materials to prepare an oral preparation.

[0019] The present invention uses epimedium, antler glue, silkworm cocoon and Cistanche deserticola as main drugs to nourish kidney yang, benefit kidney essence and strengthen tendons and bones; uses Eclipta prostrata, mistletoe, Cnidium monnieri and Dipsacus as assistant drugs to nourish liver and kidney; uses Rubus idaeus, Plantago asiatica, Astragalus complanatus, Jerusalem artichoke and Coriolus versicolor as adjuvant drugs to nourish kidney qi, promote diuresis and remove dampness, and warm and nourish liver and kidney; uses Lycium barbarum and Chinese yam as guiding drugs to nourish yin and nourish kidney, and invigorate qi and nourish yin; the prescription is mainly composed of warming and invigorating kidney yang, strengthening tendons and bones, and has the effects of promoting diuresis and removing dampness, invigorating qi and nourishing blood, and can be used for osteoporosis.

[0020] The efficacy test of the present invention confirms that the Chinese medicine composition of the present invention can reduce the influence of alkaline phosphatase in the serum of osteoporosis model mice, improve the number of femoral trabeculae, make them arranged in an orderly manner and have a complete structure.

[0021] Clinical use results have confirmed that the Chinese medicine composition of the present invention can significantly increase the patient's bone density and serum calcium and phosphorus concentrations, improve clinical symptoms such as lumbar pain and limb pain, and its total clinical treatment effective rate reaches 93.3%, and the clinical treatment effect of osteoporosis is significant. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Attached Figure 1 Pathological images of the femurs of mice in each group, wherein A is the blank group, B is the model group, C is the Example 1 group, D is the Example 2 group, E is the Example 3 group, and F is the Example 4 group. DETAILED DESCRIPTION

[0023] The present invention is further explained below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention. After reading the present invention, various equivalent modifications to the present invention by those skilled in the art all fall within the scope of protection of the claims of this application.

[0024] Example 1: A compound Chinese medicine composition for treating osteoporosis

[0025] Take 80g of antler glue and crush it into antler glue fine powder for later use; take 100g of Epimedium, 80g of Morus alba, 55g of Cnidium monnieri, 60g of Dipsacus asper, 60g of Viscum album, and 65g of Eclipta prostrata, and extract them by reflux with 65% by volume ethanol solution to obtain an extract for later use; add 8 times the amount of water to 75g of Cistanche, 55g of Rubus idaeus, 30g of Plantago, 60g of Versicolor, 60g of Lycium barbarum, 50g of Dioscorea opposita, 45g of Astragalus membranaceus, and 60g of Jerusalem artichoke, and decoct them, and the decoction is for later use; combine the obtained extract and decoction, concentrate them into a thick paste, add antler glue fine powder, mix well, filter, and add sodium benzoate to obtain an oral solution.

[0026] Example 2: A compound Chinese medicine composition for treating osteoporosis

[0027] Take 80g of antler glue and crush it into antler glue fine powder for later use; take 100g of Epimedium, 80g of Morus Alba, 55g of Cnidium monnieri, and 60g of Dipsacus asper, and reflux extract with 65% by volume ethanol solution to obtain an extract for later use; add 8 times the amount of water to 75g of Cistanche, 55g of Rubus idaeus, 30g of Plantago, 60g of Coriolus versicolor, 60g of Lycium barbarum, and 50g of Dioscorea opposita to boil, and the decoction is for later use; combine the obtained extract and decoction, concentrate to a thick paste, add antler glue fine powder, mix well, filter, and add sodium benzoate to obtain an oral solution.

[0028] Example 3: A compound Chinese medicine composition for treating osteoporosis

[0029] Take 50g of antler glue and crush it into antler glue fine powder for later use; take 120g of Epimedium, 90g of Morus alba, 60g of Cnidium monnieri, 50g of Dipsacus asper, 70g of Viscum album, and 50g of Eclipta prostrata, and reflux extract with 65% by volume ethanol solution to obtain an extract for later use; add 8 times the amount of water to 60g of Cistanche deserticola, 60g of Rubus idaeus, 20g of Plantago, 80g of Coriolus versicolor, 50g of Lycium barbarum, 60g of Dioscorea opposita, 50g of Astragalus membranaceus, and 50g of Jerusalem artichoke, and decoct them, and the decoction is for later use; combine the obtained extract and decoction, concentrate them into a thick paste, add antler glue fine powder, mix well, filter, and add sodium benzoate to obtain an oral solution.

[0030] Example 4: A compound Chinese medicine composition for treating osteoporosis

[0031] Take 120g of antler glue and crush it into antler glue fine powder for later use; take 50g of Epimedium, 30g of Morus alba, 25g of Cnidium monnieri, 100g of Dipsacus asper, 30g of Viscum album, and 100g of Eclipta prostrata, and reflux extract with 65% by volume ethanol solution to obtain an extract for later use; add 8 times the amount of water to 100g of Cistanche, 30g of Rubus idaeus, 50g of Plantago, 30g of Coriolus versicolor, 80g of Lycium barbarum, 30g of Dioscorea opposita, 80g of Astragalus membranaceus, and 20g of Jerusalem artichoke, and decoct the decoction for later use; combine the obtained extract and decoction, concentrate to a thick paste, add antler glue fine powder, mix evenly, filter, and add sodium benzoate to obtain an oral solution.

[0032] Example 5: A compound Chinese medicine composition for treating osteoporosis

[0033] 100g of antler glue is crushed into antler glue fine powder for later use; 80g of epimedium, 60g of mulberry silkworm sheath, 40g of cnidium monnieri, 70g of dipsacus, 50g of mistletoe, and 80g of Eclipta prostrata are extracted by reflux with 65% ethanol solution by volume to obtain an extract for later use; 80g of Cistanche deserticola, 50g of raspberry, 35g of Plantago, 50g of Versicolor, 70g of Lycium barbarum, 40g of yam, 30g of Astragalus, and 80g of Jerusalem artichoke are added with 8 times the amount of water for decoction, and the decoction is for later use; the obtained extract and decoction are combined, concentrated, antler glue fine powder is added, dried, starch and cyclodextrin are added, mixed evenly, and tableted to obtain tablets.

[0034] Example 6: A compound Chinese medicine composition for treating osteoporosis

[0035] Take 90g of antler glue and grind it into antler glue fine powder for later use; take 90g of Epimedium, 70g of Morus alba, 50g of Cnidium monnieri, 65g of Dipsacus asper, 65g of Viscum album, and 70g of Eclipta prostrata, and extract them by reflux with 65% by volume ethanol solution to obtain an extract for later use; add 8 times the amount of water to 65g of Cistanche, 55g of Rubus idaeus, 25g of Plantago, 70g of Coriolus versicolor, 65g of Lycium barbarum, 45g of Dioscorea opposita, 35g of Astragalus membranaceus, and 75g of Jerusalem artichoke, and decoct them, and the decoction is for later use; combine the obtained extract and decoction, concentrate them into a thick paste, add antler glue fine powder, mix them evenly, dry them, add starch, wet granulate them, and dry them to obtain granules.

[0036] Example 7: A compound Chinese medicine composition for treating osteoporosis

[0037] Take 110g of antler glue and grind it into antler glue fine powder for later use; take 130g of epimedium, 40g of mulberry silkworm sheath, 70g of cnidium monnieri, 90g of dipsacus, 80g of mistletoe, and 90g of Eclipta prostrata, and reflux extract with 65% by volume ethanol solution to obtain an extract for later use; add 8 times the amount of water to 90g of Cistanche deserticola, 70g of raspberry, 40g of Plantago, 90g of Versicolor, 40g of wolfberry, 75g of yam, 70g of Astragalus, and 90g of Jerusalem artichoke, and decoct them, and the decoction is for later use; combine the obtained extract and decoction, concentrate them into a thick paste, add antler glue fine powder, mix evenly, dry, add starch and cyclodextrin, mix evenly, wet granulate, dry, and put them into capsules to obtain capsules.

[0038] Example 8: A compound Chinese medicine composition for treating osteoporosis

[0039] Take 30g of antler glue and crush it into antler glue fine powder for later use; take 150g of epimedium, 100g of mulberry silkworm sheath, 80g of cnidium monnieri, 30g of dipsacus, 100g of mistletoe, and 20g of Eclipta prostrata, and reflux extract with 65% by volume ethanol solution to obtain an extract for later use; add 8 times the amount of water to 50g of Cistanche, 80g of Rubus idaeus, 10g of Plantago, 100g of Versicolor, 30g of Lycium barbarum, 80g of Dioscorea opposita, 20g of Astragalus membranaceus, and 100g of Jerusalem artichoke, and decoct the decoction for later use; combine the obtained extract and decoction, concentrate to a thick paste, add antler glue fine powder, mix evenly, add syrup, and filter to obtain a syrup.

[0040] Efficacy test

[0041] In order to verify the efficacy of the Chinese medicine composition and Chinese medicine preparation of the present invention in preventing or treating osteoporosis, the inventors conducted relevant pharmacodynamic experiments. The following pharmacodynamic experiments list the therapeutic effects of some Chinese medicine compositions of the present invention on glucocorticoid-induced osteoporosis.

[0042] 1 Materials

[0043] 1.1 Animals:

[0044] Kunming mice, 20 ± 2 g, experimental animal license number: SYXK (Su) 2023-0036, were purchased from Jiangsu Jicui Yaokang Biotechnology Co., Ltd. and were adaptively raised for one week before the experiment.

[0045] 1.2 Drugs and reagents

[0046] 1.2.1 Drugs

[0047] Oral liquid obtained from Examples 1-4 of the present invention

[0048] 1.2.3 Dosage

[0049] 4 mL / kg

[0050] 2. Experimental process and data processing

[0051] 2.1 Modeling and treating mice with glucocorticoid-induced osteoporosis in reference to the prior art

[0052] Fifty mice were randomly divided into a model group, Example 1 group, Example 2 group, Example 3 group, and Example 4 group; the mice in the model group were injected with 0.2 mL of dexamethasone sodium phosphate dilution into the gluteal muscle twice a week, and were given normal saline by gavage once a day; the mice in Example 1-4 groups were injected with 0.2 mL of dexamethasone sodium phosphate dilution into the gluteal muscle twice a week, and were given the corresponding drugs by gavage once a day; 10 mice were taken as the blank group, and 0.2 mL of normal saline was injected into the gluteal muscle twice a week, and normal saline was given by gavage once a day; the drugs were administered continuously for 6 weeks.

[0053] Preparation method of dexamethasone sodium phosphate diluent: take 1mL of dexamethasone sodium phosphate injection and add 49mL of normal saline to make 50mL to obtain the diluent.

[0054] 2.2 Detection indicators

[0055] 24 hours after the last oral administration, the mice were killed, blood was collected from the eyeballs and the serum was separated to monitor the concentration of alkaline phosphatase in the serum; the mice were fixed on the operating table, the left femur was removed, slices were made, and the morphology and structure of bone tissue were observed.

[0056] 2.3 Data processing

[0057] SPSS 22.0 software was used to perform statistical analysis on the data, and one-way analysis of variance was used for comparison. The difference was considered statistically significant when P < 0.05.

[0058] 3. Results and Conclusions

[0059] 3.1 Serum ALP concentration

[0060] The ALP in the serum of the model group was significantly increased; compared with the model group, the ALP in the serum of the mice in Example 1-4 groups were reduced to varying degrees. The results are shown in Table 1.

[0061] Table 1 Changes in serum ALP levels in each group of mice ( n=10)

[0062]

[0063]

[0064] Note: Compared with the model group, *P<0.05

[0065] 3.2 Bone changes

[0066] Compared with the blank group, the trabecular structure of the rats in the model group was significantly damaged, the number of trabeculae decreased, disordered, thinned, the spacing increased, and the osteoporosis was serious. After a period of treatment with the oral liquid of the Chinese medicine composition obtained in Examples 1-4 of the present invention, the thickness of the trabeculae increased significantly. Compared with the model group, the trabeculae of the mice in each example group were arranged in an orderly manner and had a complete structure. The structure of the mice in Example 1 group was more complete and the arrangement was more orderly. In summary, it is preliminarily shown that the Chinese medicine composition of the present invention can improve the structure of trabeculae to a certain extent, thereby improving osteoporosis. The results are shown in the attached Figure 1 .

[0067] Clinical effect

[0068] 1. Objects and methods

[0069] 1.1 Research subjects

[0070] The patients were 30 osteoporosis patients admitted to our hospital. According to the treatment plan, they were divided into a control group and an observation group, with 15 cases in each group. There was no statistically significant difference in the general data such as gender, age, and condition between the two groups (P>0.05), and parallel control between the groups could be performed.

[0071] Patient inclusion criteria: (1) diagnosed with osteoporosis according to the relevant standards in the "Guidelines for the Diagnosis and Treatment of Primary Osteoporosis"; (2) dual-energy X-ray examination showed decreased femoral neck density and lumbar spine density, with a T value of -2.5 or below; (3) the patient or family members were satisfied and agreed.

[0072] 1.2 Methods

[0073] Control group: Oral treatment with alfacalcidol tablets (etidronate disodium tablets, 0.2g, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.), 0.2g at a time, twice a day, between meals, with appropriate dosage adjustment according to the patient's symptoms.

[0074] Observation group: Based on the treatment of the control group, the oral liquid obtained in Example 1 of the present invention was given, 10 ml each time, 3 times a day.

[0075] The treatment time for both groups of patients was 6 weeks.

[0076] 1.3 Observation indicators

[0077] (1) The lumbar spine bone density and femoral neck bone density were measured in the two groups of patients before and after treatment.

[0078] (2) Examine the changes in serum calcium and phosphorus levels of the two groups of patients before and after treatment.

[0079] 1.4 Evaluation of efficacy

[0080] According to the "Orthopedic Disease Efficacy Evaluation Criteria", the effects of the two groups of patients after treatment were determined:

[0081] Significant effect means that clinical symptoms such as back pain and limb pain disappear, and bone density increases significantly compared with before treatment;

[0082] Effective means that symptoms such as back pain and limb pain are significantly relieved, and the increase in bone density is within the effective range;

[0083] Ineffectiveness means that the pain symptoms in the limbs and back are not significantly relieved, or the condition is serious.

[0084] The total clinical effective rate = (number of patients with marked effect + number of patients with effective effect) / total number of patients × 100%.

[0085] 1.5 Statistics

[0086] The clinical data in this study were processed using the statistical software SPSS 22.0. P < 0.05 indicated that the difference was statistically significant.

[0087] 2 Results

[0088] 2.1 Comparison of bone density between the two groups before and after treatment

[0089] Before treatment, there was no significant difference in lumbar spine bone density and left femoral tibia bone density between the two groups (P>0.05); after treatment, both groups showed significant improvement compared with before treatment (P<0.05), and the bone density improvement effect of the observation group was better than that of the control group (P<0.05). The results are shown in Table 2.

[0090] Table 2 Changes in bone density of the two groups of patients before and after treatment ( g / cm 3 )

[0091]

[0092] Note: Compared with the same group before treatment, * P<0.05; compared with the control group after treatment, # P<0.05.

[0093] 2.3 Comparison of serum calcium and phosphorus levels between the two groups of patients before and after treatment

[0094] Before treatment, the serum calcium and serum phosphorus levels of the two groups of patients were similar (P>0.05); after treatment, the serum calcium and serum phosphorus levels of the two groups increased significantly (P<0.05), and the increase in the observation group was higher than that in the control group. The results are shown in Table 3.

[0095] Table 3 Changes of serum calcium and phosphorus in the two groups of patients before and after treatment ( mmol / L)

[0096]

[0097] Note: Compared with the same group before treatment, * P<0.05.

[0098] 2.4 Comparison of clinical treatment effects between the two groups of patients

[0099] The total effective rate of the observation group was 93.3%, which was significantly better than that of the control group (86.8%). The results are shown in Table 4.

[0100] Table 4 Comparison of clinical treatment effects between the two groups of patients

[0101] Group Number of examples (examples) Significantly effective (example) Valid (Example) Invalid (Example) Total effective rate (%) Control group 15 5 8 2 86.8 Observation Group 15 8 6 1 93.3

Claims

1. A compound Chinese medicine composition for treating osteoporosis, characterized in that: APIs include: 50-150 parts by weight of epimedium, 30-120 parts by weight of antler glue, 30-100 parts by weight of silkworm cocoon, 50-100 parts by weight of Cistanche deserticola, 25-80 parts by weight of Cnidium monnieri, 30-100 parts by weight of Dipsacus asper, 30-80 parts by weight of Rubus idaeus, 10-50 parts by weight of Plantago, 30-100 parts by weight of Versicolor, 30-80 parts by weight of Lycium barbarum, and 30-80 parts by weight of Dioscorea opposita.

2. The compound Chinese medicine composition according to claim 1, wherein: 80-120 parts by weight of epimedium, 50-100 parts by weight of antler glue, 60-90 parts by weight of silkworm cocoon, 60-80 parts by weight of Cistanche deserticola, 40-60 parts by weight of Cnidium monnieri, 50-70 parts by weight of Dipsacus asper, 50-60 parts by weight of Rubus idaeus, 20-35 parts by weight of Plantago, 50-80 parts by weight of Versicolor, 50-70 parts by weight of Lycium barbarum, and 40-60 parts by weight of Dioscorea opposita.

3. The compound Chinese medicine composition according to claim 1 or 2, characterized in that: The raw materials also include: 20-100 parts by weight of Eclipta prostrata, 30-100 parts by weight of Viscum album, 20-80 parts by weight of Astragalus membranaceus, and 20-100 parts by weight of Jerusalem artichoke.

4. The compound Chinese medicine composition as claimed in claim 3, wherein: 50-80 parts by weight of Eclipta prostrata, 50-70 parts by weight of Viscum album, 30-50 parts by weight of Astragalus membranaceus, and 50-80 parts by weight of Jerusalem artichoke.

5. The compound Chinese medicine composition according to claim 4, characterized in that: The preparation method of the compound Chinese medicine composition comprises the following steps: crushing antler glue into antler glue fine powder for later use; refluxing and extracting epimedium, mulberry silkworm sheath, cnidium monnieri, dipsaccharum officinale, mistletoe and Eclipta prostrata with 50-70% by volume ethanol solution to obtain an extract for later use; adding 5-10 times the amount of water to decoct Cistanche deserticola, raspberry, plantago seed, versicolor, wolfberry, yam, astragalus and Jerusalem artichoke, and preparing the decoction for later use; combining the obtained extract and decoction, concentrating, and adding antler glue fine powder to obtain the compound Chinese medicine composition.

6. Use of a compound Chinese medicine composition in preparing a drug for treating osteoporosis, characterized in that: The compound Chinese medicine composition is the compound Chinese medicine composition according to any one of claims 1 to 5.

7. A Chinese medicine preparation for treating osteoporosis, characterized in that: The Chinese medicine preparation is prepared from the compound Chinese medicine composition described in any one of claims 1 to 5.

8. The Chinese medicine preparation according to claim 7, characterized in that: The traditional Chinese medicine preparation is a clinically acceptable oral preparation.

9. The Chinese medicine preparation according to claim 8, characterized in that: The oral preparation is an oral solid preparation or a liquid preparation.

10. The Chinese medicine preparation according to claim 9, characterized in that: The oral solid preparation is at least one of a capsule, a tablet, and a granule; the oral liquid preparation is an oral liquid or a syrup.

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