Chinese medicine composition, Chinese medicine preparation, preparation method and application

Abstract

The present invention relates to the technical field of traditional Chinese medicine, and more particularly to a Chinese medicine composition, a Chinese medicine preparation, a preparation method and an application. In the present invention, the Chinese medicine composition is prepared by including the following raw materials in parts by weight: 5-50 parts of Astragalus, 5-50 parts of Honeysuckle, 0-30 parts of Green Sorbus, 0-15 parts of Toona bark, 3-15 parts of Rhubarb, 3-15 parts of Magnolia officinalis, 3-15 parts of Sappan wood, and 3-30 parts of Smilax glabra. The Chinese medicine composition can tonify the middle qi, invigorate blood circulation, strengthen the body, eliminate evil, detoxify and relieve stranguria. It is used to treat urinary tract infection of damp-heat type, and the prescription compatibility embodies the traditional Chinese medicine concept of treating both the symptoms and the root cause. Western medicine efficacy studies have shown that the Chinese medicine composition can be used to treat urinary tract infection, and can reduce the recurrence rate, thereby effectively preventing and treating recurrent urinary tract infection.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and an application thereof. Background Art

[0002] Urinary tract infection is a common multiple disease and one of the most common infectious diseases in adults. According to statistics, about 1 / 3 of adult women have experienced symptomatic urinary tract infection in their lifetime, and 27%-28% of healthy women may have repeated urinary tract infection.

[0003] Currently, Western medicine has no effective method to treat urinary tract infections, especially recurrent urinary tract infections, and reduce the recurrence rate.

[0004] Clinically, antibiotics such as sulfonamides, quinolones, semi-synthetic penicillins or cephalosporins are usually selected for treatment in the form of one or more combinations, with the aim of killing or inhibiting pathogens and controlling infection. This method shows a high cure rate for patients with primary urinary tract infection, but there are problems such as incomplete treatment and recurrence of the disease. In addition, for patients with urinary tract infection with poor immune function, the use of broad-spectrum antibiotics cannot effectively control the infection. Long-term and repeated use of broad-spectrum antibiotics by patients can easily lead to fungal infections, the production of drug-resistant strains, and dysbiosis, which in turn brings greater difficulties to clinical treatment.

[0005] The prior art discloses some traditional Chinese medicine treatment methods suitable for urinary tract infection.

[0006] For example, "Clinical Study on Tonglin Huayu Recipe for Treating Recurrent Lower Urinary Tract Infection with Heat and Stasis Syndrome" discloses a Tonglin Huayu Recipe suitable for recurrent lower urinary tract infection, and the raw materials include pollen, talcum powder, honeysuckle, radix polygoni multiflori, radix dianthus, smilax glabra, peach kernel, rhubarb, angelica, Fritillaria thunbergii, cinnamon twig, radix bupleuri and radix scutellariae. "Clinical Experience of Master of Traditional Chinese Medicine Lu Fang in Treating Pyelonephritis with Migan Decoction" discloses a self-made prescription "Migan Decoction" for treating pyelonephritis, and the raw materials include honeysuckle, forsythia, dandelion, Viola yedoensis, Magnolia officinalis, Sappan wood, smilax glabra, rhubarb, verbena, Centella asiatica, Patrinia salsa, elderberry and scutellaria baicalensis. Although these Chinese medicine formulas have a certain therapeutic effect on recurrent urinary tract infection, there are problems such as more medicinal flavors in the prescription, larger dosage, slow onset of effect and long course of treatment.

[0007] In view of this, the present invention is proposed. Summary of the invention

[0008] In order to solve the above technical problems, the present invention provides a Chinese medicine composition for treating urinary tract infection and effectively reducing the recurrence rate, thereby preventing and treating recurrent urinary tract infection. The prescription compatibility embodies the traditional Chinese medicine concept of treating both the symptoms and the root cause, and can replenish the middle qi, invigorate blood circulation, strengthen the body, eliminate evil, detoxify and relieve stranguria. Western medicine efficacy studies have shown that the Chinese medicine composition can effectively treat urinary tract infection, resist bacteria and inflammation, eliminate inflammatory reactions of the urinary system, regulate the body's immune function, and reduce the recurrence rate.

[0009] Specifically, the technical solution of the present invention is as follows.

[0010] The invention provides a traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 5-50 parts of astragalus, 5-50 parts of honeysuckle, 0-30 parts of green osmanthus, 0-15 parts of toon bark, 3-15 parts of cooked rhubarb, 3-15 parts of magnolia bark, 3-15 parts of sappan wood, and 3-30 parts of smilax glabra.

[0011] The Chinese medicine composition of the present invention has a good therapeutic effect on urinary tract infection and recurrent urinary tract infection.

[0012] Specifically, in the Chinese medicine composition of the present invention, the efficacy and compatibility principles of each raw material are as follows:

[0013] Astragalus is the main drug. It is sweet and slightly warm in nature. It enters the lung and spleen meridians. It has the functions of replenishing qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving arthritis, expelling toxins and draining pus, and astringing sores and promoting tissue regeneration. The prescription uses a lot of Astragalus to replenish qi, raise yang and consolidate the exterior, and command all the drugs to play the role of strengthening the body and eliminating evil, and treating both the symptoms and the root cause.

[0014] Honeysuckle, Forsythia, Toona bark, and Rhubarb are the ministerial drugs. Among them, Honeysuckle is sweet and cold. It enters the lung, heart, and stomach meridians. It has the effects of clearing away heat and detoxifying, and dispersing wind-heat. Forsythia is bitter and slightly cold. It enters the lung, heart, and small intestine meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing knots, and dispersing wind-heat. Rhubarb is bitter and cold. It enters the spleen, stomach, large intestine, liver, and pericardium meridians. It has the effects of purging and attacking accumulation, clearing heat and purging fire, cooling blood and detoxifying, removing blood stasis and dredge meridians, and removing dampness and jaundice. Toona bark is bitter, astringent, and cold. It enters the large intestine, stomach, and liver meridians. It has the effects of clearing heat and drying dampness, astringing and stopping leukorrhea, stopping diarrhea, and stopping bleeding. Honeysuckle, Forsythia, and Rhubarb are all cold medicines. The combination of these medicines can clear heat and purge fire, cool blood and detoxify, but they are too cold and will excessively damage the body's righteousness after a long illness. Chinese toon bark helps to clear away heat, and also has the effect of astringing and drying dampness, but it is not a product of dryness and heat, and will not turn dryness into damage to Yin. Chinese toon bark can be used in combination with honeysuckle, forsythia, and rhubarb to achieve synergistic synergy, but it has the effect of astringing while purging, astringing while cooling, and yin and yang are adjusted to achieve yin and yang balance. In the present invention, honeysuckle and forsythia are specifically used to help clear away heat and detoxify; Chinese toon bark clears heat and dries dampness; cooked rhubarb clears heat and purges fire, cools blood and detoxifies, and guides stagnation. The four ministerial drugs are used together to quickly relieve symptoms such as frequent urination, painful urination, urgent urination, short and red urine, and drizzling urine.

[0015] Magnolia officinalis and Su Mu are both adjuvants. Su Mu promotes blood circulation, removes blood stasis, relieves swelling and relieves pain; Magnolia officinalis dries dampness and eliminates phlegm, relieves qi and relieves fullness. The two adjuvants work together to promote qi and blood circulation and relieve pain.

[0016] Wild Smilax glabra can detoxify, remove dampness, open up joints, guide meridians and report to the messenger. It is the guiding drug in the prescription, leading all the drugs to reach the site of the disease.

[0017] The above-mentioned compatibility of the Chinese medicine composition of the present invention can tonify the middle qi, invigorate blood circulation, strengthen the body, eliminate evil, detoxify and relieve stranguria, hit the pathogenesis, and has the ability to treat both the symptoms and the root cause.

[0018] Based on the above treatment principles, in a preferred embodiment of the present invention, the Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of Astragalus, 10-40 parts of Honeysuckle, 10-25 parts of Green Sorbus, 3-10 parts of Chinese toon bark, 3-10 parts of cooked rhubarb, 6-15 parts of Magnolia officinalis, 5-12 parts of Sappan wood, and 5-15 parts of Smilax glabra.

[0019] Alternatively, the Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of Astragalus, 10-20 parts of Honeysuckle, 10-20 parts of Cyperus rotundus, 3-9 parts of Toona sinensis bark, 3-9 parts of Rhubarb, 8-12 parts of Magnolia officinalis, 6-12 parts of Sappan wood, and 8-12 parts of Smilax glabra.

[0020] More preferably, the Chinese medicine composition of the present invention is prepared from the following raw materials in parts by weight: 25 parts of Astragalus, 15 parts of Honeysuckle, 15 parts of Green Sorbus atractylodes, 6 parts of Chinese toon bark, 6 parts of Rhubarb, 10 parts of Magnolia officinalis, 9 parts of Sappan wood, and 10 parts of Smilax glabra.

[0021] The present invention does not particularly limit the sources of the above-mentioned raw materials, and any raw material from conventional commercial sources in the field can be used.

[0022] The Chinese medicine composition provided by the present invention is a pure Chinese medicine formula, which has the effects of tonifying the middle qi, invigorating blood circulation, strengthening the body, eliminating evil, detoxifying and relieving stranguria. It is used to treat urinary tract infection of damp-heat type, with symptoms of urinary urgency, frequent urination, dysuria, yellow and turbid urine, lower abdominal cramps, back pain, or accompanied by aversion to cold and fever, bitter taste in the mouth, nausea and vomiting, and dry stool. Recurrent urinary tract infection with the above symptoms.

[0023] In a second aspect, the present invention provides a traditional Chinese medicine preparation, which is prepared from the traditional Chinese medicine composition alone, or from the traditional Chinese medicine composition and a pharmaceutically acceptable carrier and / or excipient.

[0024] The present invention does not specifically limit the specific dosage form of the Chinese medicine preparation. In an optional embodiment of the present invention, the dosage form of the Chinese medicine preparation is tablets, pills, capsules, granules, granules, powders, pastes, oral liquids or mixtures.

[0025] In a third aspect, the present invention provides a method for preparing the Chinese medicine preparation, comprising the following steps:

[0026] S1. Weigh each raw material drug by weight, and process it to obtain Chinese herbal medicine slices;

[0027] S2, placing the Chinese herbal medicine pieces in an extraction solvent to obtain an extract;

[0028] S3. Combining the extract with the carrier and / or excipient to obtain a Chinese medicine preparation.

[0029] Preferably, the extraction solvent in step S2 is water.

[0030] Preferably, the traditional Chinese medicine preparation is a granule.

[0031] In the present invention, the preparation method of the granules preferably comprises the following steps: the medicinal materials in each formula are cleaned and cut, weighed according to the ratio, added with 8 times the amount of water, soaked for 0.5 hours, boiled and extracted twice, the first extraction time is 1 hour, the second extraction time is 0.5 hours, filtered and concentrated at 60°C to a relative density of 1.10-1.30, added with an appropriate amount of dextrin, granulated, dried, granulated, and packaged to obtain granules.

[0032] The preparation method provided by the present invention has a simple process. The granules prepared by the above preparation method have low production cost, safe and pollution-free production process, simple process, stable quality and long shelf life. The effective components extracted with water as solvent have high solubility and are easy to be absorbed and utilized by the body.

[0033] In a fourth aspect, the present invention provides the use of the Chinese medicine composition or the Chinese medicine preparation in the preparation of a drug for treating urinary tract infection and preventing and / or treating recurrent urinary tract infection.

[0034] In the present invention, the symptoms of urinary tract infection and recurrent urinary tract infection preferably include at least one of frequent urination, urgent urination, painful urination, nocturia, suprapubic pain, lower abdominal cramps, turbid yellow urine, pyuria, hematuria, low back pain, fatigue, chills and fever, nausea and vomiting, and relief after urination.

[0035] Beneficial effects:

[0036] The present invention provides a Chinese medicine composition, a Chinese medicine preparation, a preparation method and an application. The Chinese medicine composition uses Astragalus as a monarch drug, honeysuckle, forsythia, Chinese toon bark and cooked rhubarb as ministerial drugs, Magnolia officinalis and Sappan wood as adjuvant drugs, and Smilax glabra as a guiding drug. Among them, the monarch, ministerial, adjuvant and guiding drugs are mutually compatible, especially the four ministerial drugs have astringency and complement each other, while expelling evil and detoxifying, taking into account the effect of assisting the monarch drug Astragalus to strengthen the body, so that the positive energy is stored inside and the evil cannot interfere. The Chinese medicine composition of the present invention can not only treat urinary tract infection, but also reduce its recurrence rate, and has a dual effect of treatment and prevention on recurrent urinary tract infection. DETAILED DESCRIPTION

[0037] The technical solutions provided by the present invention are described in detail below in conjunction with the examples, but they should not be understood as limiting the scope of protection of the present invention. Unless otherwise specified, the experimental methods used in the examples are conventional methods; the materials and reagents used can be obtained from commercial sources.

[0038] Example 1

[0039] This embodiment provides a Chinese medicine composition, and the Chinese medicine composition has the following formula in parts by weight:

[0040] Astragalus 25g, honeysuckle 15g, green osmanthus 15g, toon bark 6g, cooked rhubarb 6g, Magnolia officinalis 10g, Sappan wood 9g, and Smilax glabra 10g.

[0041] This embodiment also provides a Chinese medicine preparation comprising the above Chinese medicine composition, and the preparation method is as follows:

[0042] The medicinal materials in each prescription were cleaned and cut, weighed according to the ratio, added with 8 times the amount of water, soaked for 0.5 h, decocted and extracted twice, the first extraction time was 1 h, and the second extraction time was 0.5 h. After filtering, the mixture was concentrated to 100 ml (relative density 1.10-1.30) at 60±10°C.

[0043] Example 2

[0044] This embodiment provides a Chinese medicine composition, and the Chinese medicine composition has the following formula in parts by weight:

[0045] Astragalus 25g, honeysuckle 20g, green osmanthus 12g, toon bark 3g, cooked rhubarb 3g, Magnolia officinalis 10g, Sappan wood 9g, and wild yam 10g.

[0046] This embodiment also provides a Chinese medicine preparation comprising the above-mentioned Chinese medicine composition, and the preparation method is the same as that of Example 1.

[0047] Example 3

[0048] This embodiment provides a Chinese medicine composition, and the Chinese medicine composition has the following formula in parts by weight:

[0049] Astragalus 30g, honeysuckle 9g, green osmanthus 25g, toon bark 9g, cooked rhubarb 9g, Magnolia officinalis 12g, Sappan wood 3g, and wild yam 15g.

[0050] This embodiment also provides a Chinese medicine preparation comprising the above-mentioned Chinese medicine composition, and the preparation method is the same as that of Example 1.

[0051] Example 4

[0052] This embodiment provides a Chinese medicine composition, and the Chinese medicine composition has the following formula in parts by weight:

[0053] Astragalus 5g, honeysuckle 30g, Qingqiao 5g, Chinese toon bark 5g, cooked rhubarb 5g, Magnolia officinalis 6g, Sappan wood 6g, and Smilax glabra 6g.

[0054] This embodiment also provides a Chinese medicine preparation comprising the above Chinese medicine composition, and the preparation method is as follows:

[0055] After the medicinal materials in each prescription are cleaned and cut, they are weighed according to the ratio, and 8 times the amount of 65% ethanol is added. After soaking for 1.0 hour, reflux extraction is performed twice, each time for 1 hour. After filtering, the alcohol is collected at 60±10°C until there is no alcohol taste, and concentrated to 100 ml (relative density 1.10-1.30).

[0056] Example 5

[0057] This embodiment provides a Chinese medicine composition, and the Chinese medicine composition has the following formula in parts by weight:

[0058] 50g of Astragalus, 15g of Honeysuckle, 15g of Chinese toon bark, 3g of Rhubarb, 6g of Magnolia officinalis, 6g of Sappan wood, and 6g of Smilax glabra.

[0059] This embodiment also provides a Chinese medicine preparation comprising the above-mentioned Chinese medicine composition, and the preparation method is the same as that of Example 4.

[0060] Example 6

[0061] This embodiment provides a Chinese medicine composition, and the Chinese medicine composition has the following formula in parts by weight:

[0062] Astragalus 25g, honeysuckle 15g, green schisandra 15g, cooked rhubarb 6g, Magnolia officinalis 10g, Sappan wood 9g, and wild yam 10g.

[0063] This embodiment also provides a Chinese medicine preparation comprising the above Chinese medicine composition, and the preparation method is as follows:

[0064] The medicinal materials in each prescription were cleaned and cut, weighed according to the ratio, added with 8 times the amount of water, soaked for 1.0 hour, refluxed and extracted twice, each time for 1 hour, filtered and concentrated to 100 ml (relative density 1.10-1.30) at 60±10°C.

[0065] Comparative Example 1

[0066] This comparative example provides a Tonglin Huayu prescription known in the prior art for recurrent lower urinary tract infection, the formula of which is as follows:

[0067] Puhuang 10g, Talcum 15g, Honeysuckle 30g, Polygonum multiflorum 15g, Dianthus superbus 15g, Smilax glabra 15g, Peach kernel 10g, Rhubarb 10g, Angelica 15g, Fritillaria thunbergii 10g, Cassia twig 6g, Bupleurum 12g, Scutellaria 10g.

[0068] This comparative example also provides a Chinese medicine preparation based on the above Tonglin Huayu prescription, and its preparation method and condition parameters are the same as those in Example 1.

[0069] Comparative Example 2

[0070] This comparative example provides a traditional Chinese medicine preparation of Migan Decoction for treating pyelonephritis known in the prior art, and the formula is as follows:

[0071] 50g of honeysuckle, 50g of forsythia, 50g of dandelion, 50g of viola yedoensis, 25g of magnolia officinalis, 25g of rhubarb, 30g of wild yam, 5g of wine rhubarb, 30g of verbena, 30g of centella asiatica, 30g of patrinia herb, 20g of elderberry, and 30g of kuncao.

[0072] This comparative example also provides a method for preparing the above-mentioned Migan Decoction Chinese medicine preparation, and the conditions and parameters are the same as those in Example 1.

[0073] Comparative Example 3

[0074] This comparative example is a commercially available Chinese medicine preparation of Sanjin Tablets, the prescription of which is: Golden Sakura Root, Smilax Sinensis, Herba Lycopodii, Herba Centellae Asiatica, and Herba Centellae Asiatica. The manufacturer is Guilin Sanjin Pharmaceutical Co., Ltd., and the approval number is National Medicine Standard Z45021601.

[0075] The Sanjin Tablets in this comparative example are heat-clearing agents, which have the effects of clearing away heat and detoxifying, promoting dampness and relieving stranguria, and benefiting the kidney. They are mainly used to treat stranguria caused by damp-heat in the lower jiao, short and red urine, dribbling and painful urine, and frequent urination; acute and chronic pyelonephritis, cystitis, and urinary tract infection with the above symptoms; chronic non-bacterial prostatitis with kidney deficiency and damp-heat.

[0076] Comparative Example 4

[0077] This comparative example is the commercially available Chinese medicine preparation Bazheng Powder, Bazheng Granules, produced by Shaanxi Dongtai Pharmaceutical Co., Ltd., with the approval number of National Medicine Standard Z20050045.

[0078] The comparative example Bazhengsan is a dampness-removing agent, which has the effects of clearing away heat and purging fire, promoting diuresis and relieving stranguria. It is mainly used to treat stranguria caused by dampness and heat; frequent urination and urgent urination, astringent pain during urination, poor stranguria, muddy and red urine, even urinary retention, acute fullness in the lower abdomen, dry mouth and throat, yellow and greasy tongue coating, and slippery and rapid pulse; it is commonly used in clinical treatment of cystitis, urethritis, acute prostatitis, urinary tract stones, pyelonephritis, postoperative or postpartum urine retention, etc., which are caused by dampness and heat.

[0079] Experimental Example 1

[0080] In this experimental example, the Chinese medicine preparations prepared in Examples 1-6 and Comparative Examples 1-4 were selected to test the efficacy of each Chinese medicine preparation.

[0081] (1) Effects of drugs on the chronic urinary tract infection model of rats caused by Escherichia coli.

[0082] A chronic urinary tract infection model was established by retrograde infection of Escherichia coli through the bladder and unilateral incomplete ureteral obstruction. After the model was successfully established, the corresponding drugs were given by gavage. The dosage of Examples 1-6 and Comparative Examples 1-2 was 1 mL / 100 g, once a day, for 15 consecutive days. Comparative Examples 3-4 were administered according to the method described in the product manual. The bladder lavage fluid of rats was collected 7 days after administration, and the number of white blood cells and pH in urine were determined. On the 15th day, the bladder and kidney tissues of rats were taken to detect organ indexes and pathological morphological changes (HE staining).

[0083] The results are shown in Tables 1 and 2.

[0084] Table 1 Comparative study results of rat bladder lavage fluid

[0085] project White blood cells (pcs / HP) PH Blank Group 0.82±0.61 6.89±0.46 Model Group 2.73±0.43 6.47±0.48 Comparative Example 1 1.76±1.01 6.72±0.63 Comparative Example 2 1.28±1.05 6.87±0.55 Comparative Example 3 1.16±1.07 6.86±0.35 Comparative Example 4 1.28±1.02 6.81±0.47 Example 1 (high dose group) 0.82±0.36 6.94±0.36 Example 1 (medium dose group) 0.85±0.41 6.92±0.36 Example 1 (low dose group) 1.01±0.32 6.91±0.55 Example 2 0.88±0.46 6.91±0.42 Example 3 1.01±0.82 6.90±0.31 Example 4 1.12±1.07 6.89±0.48 Example 5 1.11±0.50 6.89±0.43 Example 6 0.90±0.39 6.90±0.37

[0086] Note: High-dose group of Example 1: twice the dosage of Example 1; medium-dose group of Example 1: once the dosage of Example 1; low-dose group of Example 1: 0.5 times the dosage of Example 1.

[0087] Compared with the blank control group, the number of white blood cells in the model group rats after urinary tract infection increased significantly (P<0.01). Compared with the model group, the number of white blood cells in the comparative example 2, Sanjin Tablets, Bazheng Powder, and the embodiment groups all decreased significantly (P<0.01), among which the number of white blood cells in the embodiment 1 group and the embodiment 2 group decreased the most.

[0088] Compared with the blank control group, the urine pH of rats in the model group after urinary tract infection was significantly reduced (P<0.01). Compared with the model group, the pH of the comparative example 2, Sanjin tablets, Bazhengsan, and the embodiment groups was significantly increased (P<0.05 or P<0.01), among which the pH of the embodiment 1 group and the embodiment 2 group was the highest.

[0089] Table 2 Organ index and pathological morphological changes

[0090]

[0091]

[0092] Note: High-dose group of Example 1: twice the dosage of Example 1; medium-dose group of Example 1: once the dosage of Example 1; low-dose group of Example 1: 0.5 times the dosage of Example 1.

[0093] The pharmacological test results show that the efficacy test results of each embodiment are significantly better than those of each comparative example, indicating that the present invention has a significant therapeutic effect on the pathological histological changes of the kidney and bladder of rats with urinary tract infection.

[0094] Experimental Example 2

[0095] This experimental example uses the Chinese medicine composition prepared in Example 1 to treat patients with recurrent urinary tract infection, and also provides the following typical cases:

[0096] Case 1:

[0097] Yu, male, 38 years old, was diagnosed with recurrent urinary tract infection by Western medicine. At the first visit in August 2019, he had urinary pain, frequent urination, backache and fatigue for more than a month. According to the previous medical prescription, he took levofloxacin hydrochloride tablets and Sanjin tablets orally for 5 days, but the symptoms did not improve. The hospital's urine routine showed: red blood cells 80 / μL, white blood cells 225 / μL, albumin 80mg / L, PH 5.0. The main symptoms of coming to the doctor were frequent urination, urgency, urinary pain, backache and fatigue, lower abdominal distension, red tongue, and smooth pulse. After coming to the doctor, the main symptoms were diagnosed as frequent and short urination, burning and stinging in the urethra, and lower abdominal cramps; secondary symptoms: yellow and turbid urine, upset, bitter mouth, dry stool; tongue and pulse: red tongue, yellow and greasy fur, and smooth pulse. Prescription for the first visit: 25g of Astragalus, 15g of Honeysuckle, 15g of Forsythia, 6g of Toona bark, 6g of Rhubarb, 10g of Magnolia officinalis, 9g of Sappan wood, 10g of Smilax glabra, decocted in water. After 7 days of follow-up, all symptoms disappeared and the patient was basically cured, with occasional back pain and fatigue, and a weak pulse. The patient was advised to continue taking the medicine for another 7 days. After another 7 days of follow-up, the patient's bowel movements were normal, the pulse was stable, and the patient was cured. The hospital's urine routine test indicators were all within the qualified range, and all physical signs were normal. There was no recurrence during follow-up.

[0098] Case 2:

[0099] Ms. Li, 52 years old, first visited the doctor in May 2018. The main complaint was that she had recurrent urinary tract infections two years ago. She had been treated with intravenous and oral antibiotics many times before. She recovered and relapsed many times within a year. The main symptoms diagnosed when she came to the doctor were: frequent urination, burning in the urethra; secondary symptoms: yellow urine, bitter taste in the mouth, backache and fatigue; tongue and pulse: red tongue, yellow and greasy fur, and thin pulse. The prescription for the first visit was: 25g of Astragalus, 15g of Honeysuckle, 15g of Forsythia, 6g of Toona bark, 6g of Rhubarb, 10g of Magnolia officinalis, 9g of Sappan wood, and 10g of Smilax glabra, decocted in water. After a follow-up visit 7 days later, she was basically cured, with occasional bitter taste in the mouth and fatigue. The second visit advised her to continue taking it for another 7 days. After another follow-up visit 7 days later, all symptoms disappeared and she was cured. There was no recurrence during follow-up.

[0100] The above-mentioned embodiments only express several implementation methods of the present invention, which is convenient for understanding the technical solution of the present invention in detail, but it cannot be understood as limiting the scope of the invention patent protection. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A Chinese medicine composition for urinary tract infection, characterized in that: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of astragalus, 10-20 parts of honeysuckle, 10-20 parts of green osmanthus, 3-9 parts of toon bark, 3-9 parts of cooked rhubarb, 8-12 parts of magnolia bark, 6-12 parts of sappan wood, and 8-12 parts of smilax glabra.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of astragalus, 15 parts of honeysuckle, 15 parts of green osmanthus, 6 parts of toon bark, 6 parts of cooked rhubarb, 10 parts of magnolia bark, 9 parts of sappan wood, and 10 parts of smilax glabra.

3. A Chinese medicine preparation, characterized in that: The Chinese medicine composition according to claim 1 or 2 is prepared alone, or is prepared from the Chinese medicine composition according to claim 1 or 2 and a pharmaceutically acceptable carrier and / or excipient.

4. The Chinese medicine preparation according to claim 3, characterized in that: The dosage form of the Chinese medicine preparation is tablets, pills, capsules, granules, powders, pastes, oral liquids or mixtures.

5. The method for preparing the Chinese medicine preparation according to claim 3 or 4, characterized in that: The steps include: S1. Weigh each raw material drug by weight, and process it to obtain Chinese herbal medicine slices; S2, placing the Chinese herbal medicine pieces in an extraction solvent to obtain an extract; S3. Combining the extract with the carrier and / or excipient to obtain a Chinese medicine preparation.

6. The method for preparing the Chinese medicine preparation according to claim 5, characterized in that: The extraction solvent in step S2 is water.

7. Use of the Chinese medicine composition according to claim 1 or 2, or the Chinese medicine preparation according to claim 3 or 4, or the Chinese medicine preparation prepared by the preparation method according to claim 5 or 6 in the preparation of a medicament for preventing or treating urinary tract infection.

8. Use of the Chinese medicine composition according to claim 1 or 2, or the Chinese medicine preparation according to claim 3 or 4, or the Chinese medicine preparation prepared by the preparation method according to claim 5 or 6 in the preparation of a medicament for preventing or treating recurrent urinary tract infection.

9. The use according to claim 7 or 8, characterized in that: The symptoms of the urinary tract infection or the recurrent urinary tract infection disease include at least one of frequent urination, urgent urination, dysuria, nocturia, suprapubic pain, lower abdominal cramps, yellow and turbid urine, pyuria, hematuria, low back pain, fatigue, chills and fever, and nausea and vomiting.

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