Ammonium chloride excipient and method for preparing the same
By modifying activated carbon and using specific processing techniques, the problem of high impurity content in industrial-grade ammonium chloride was solved, resulting in the preparation of high-purity ammonium chloride excipients suitable for the pharmaceutical raw material field.
CN116715254BActive Publication Date: 2026-07-24HUNAN HAOSEN PHARM CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUNAN HAOSEN PHARM CO LTD
- Filing Date
- 2023-07-07
- Publication Date
- 2026-07-24
AI Technical Summary
Technical Problem
Traditional industrial-grade ammonium chloride contains a high amount of impurities and cannot be used as an excipient in pharmaceutical raw materials. It requires further refining to meet high purity requirements.
Method used
Decolorization and impurity removal are achieved by using modified activated carbon, combined with steps such as ethanol dissolution, vacuum concentration and dichloromethane dispersion, and modified with magnetic activated carbon and polydopamine, thus achieving efficient impurity removal.
Benefits of technology
High-purity ammonium chloride excipients were prepared with a purity of 99.99%, meeting the requirements for use in active pharmaceutical ingredients. The process is simple and the conditions are mild.
✦ Generated by Eureka AI based on patent content.
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Abstract
The application provides an ammonium chloride auxiliary material and a preparation method thereof, and belongs to the technical field of bulk drugs, and comprises the following steps: (1) adding anhydrous ethanol into a reaction kettle, adding industrial-grade ammonium chloride into the reaction kettle under stirring, and stirring and dissolving; (2) adding modified activated carbon for decolorization and impurity removal; (3) performing secondary filtration to obtain ammonium chloride fine filtrate; (4) performing reduced-pressure concentration and slow cooling; (5) adding dichloromethane into the reaction kettle to stir and disperse the solid, and stirring; (6) performing centrifugation, rinsing the crystal with dichloromethane, and not recycling the filtrate; and (7) drying the wet product in an oven, controlling the temperature at 35±2 DEG C, and taking water content of less than or equal to 1.0% as an internal control standard to obtain ammonium chloride dry product. The preparation method of the ammonium chloride auxiliary material is simple in operation and mild in process conditions, the prepared ammonium chloride auxiliary material is high in purity, and meets the use requirements of bulk drugs.
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