Applications of polynucleotides, proteins, and biological materials in regulating plant tuber development, and related products and cultivation methods

Abstract

This application relates to the field of plant genetic engineering, and particularly to the application of polynucleotides, proteins, and biological materials in regulating tuber development in plants, as well as related products and cultivation methods. The polynucleotide is the nucleotide sequence shown in SEQ ID NO:1; or its complementary sequence, degenerate sequence, or homologous sequence; or a polynucleotide that hybridizes with the nucleotide sequence shown in SEQ ID NO:1 under stringent conditions or its complementary sequence; or the cDNA sequence of any of the above sequences. This polynucleotide is an identity gene of the tuber, and can control whether tubers are formed, the formation time, and the regulation of tuber size, etc. by regulating protein function, expression level, etc.

Description

Technical Field

[0001] The present invention relates to the field of plant genetic engineering, and particularly to the application of polynucleotides, proteins, and biological materials in regulating plant tuber development, as well as related products and cultivation methods. Background Art

[0002] Potatoes are native to the Andes Mountains in South America and are annual dicotyledonous plants of the Solanaceae family. Potato tubers are modified organs formed by the swelling of the apical part of underground stolons and are both the reproductive organs and the product organs of potatoes. Therefore, the study of the formation mechanism of potato tubers not only has important guiding significance for the breeding of seed potatoes, the improvement of potato yield, and the improvement of quality traits in application, but also is the key content of the study of the development of plant modified organs and has important scientific significance. Under natural conditions, the formation of potato tubers is divided into two independent biological processes: the formation of stolons and the swelling of the apical part of stolons, and must go through five steps: the occurrence of stolons, the elongation of stolons, the cessation of longitudinal growth of stolons, the radial growth of the apical part of stolons, the occurrence of tubers, and the swelling of tubers.

[0003] Although scientists have conducted many studies related to potato tuber development, the formation of tubers is a very complex biological process and is the result of the combined action of various plant endogenous signals and the external environment. The key regulatory genes for tuber formation remain to be further explored, especially the identity genes controlling tuber occurrence have not been reported. Summary of the Invention

[0004] In view of this, the present invention provides the application of polynucleotides, proteins, and biological materials in regulating plant tuber development, as well as related products and cultivation methods. The polynucleotide IT1 is the identity gene of tubers and can control the formation of tubers, the formation time, and the regulation of tuber size, etc. by regulating protein function, expression level, etc.

[0005] In order to achieve the above-mentioned invention object, the present invention provides the following technical solutions:

[0006] On the one hand, the present invention provides the application of a polynucleotide in regulating plant tuber development, which comprises at least one of the following nucleotide sequences:

[0007] 1) The nucleotide sequence shown in SEQ ID NO:1;

[0008] 2) The complementary sequence, degenerate sequence, or homologous sequence of the sequence shown in SEQ ID NO:1, wherein the homologous sequence is a polynucleotide having 75% or more identity with the nucleotide shown in SEQ ID NO:1;

[0009] 3) A polynucleotide or its complementary sequence that hybridizes with the nucleotide sequence shown in SEQ ID NO:1 under stringent conditions;

[0010] 4) The cDNA sequence of any one of the sequences 1)-3);

[0011] 5) The nucleotide sequence shown in SEQ ID NO:3;

[0012] 6) The complementary sequence, degenerate sequence, truncated sequence or homologous sequence of the sequence shown in SEQ ID NO:3, wherein the homologous sequence is a polynucleotide having 75% or more identity with the nucleotide shown in SEQ ID NO:3;

[0013] 7) A polynucleotide or its complementary sequence that hybridizes with the nucleotide sequence shown in SEQ ID NO:3 under stringent conditions;

[0014] 8) The cDNA sequence of any one of the sequences 5)-7).

[0015] In the present invention, by analyzing the RNA-seq data of different tissues of potato, a TCP transcription factor IT1 specifically expressed in potato tubers was identified. By constructing a site-directed mutagenesis vector CRISPR-IT1 based on the CRISPR / Cas9 system, the site-directed mutagenesis vector was transferred into potato plants using an Agrobacterium-mediated transgenic system, and transgenic positive lines were obtained through resistance screening and PCR verification. For the transgenic lines with site-directed mutagenesis, the DNA of the plants was extracted and the lines with IT1 function deficiency were screened by PCR and sequencing methods. The screened transgenic lines were used for subsequent phenotypic observation, and it was found that the formation of tubers in the transgenic lines with IT1 function deficiency was severely affected. The stolons did not further swell to form tubers, but grew upward to form a new plant. By disabling the function of IT1, potato materials that do not form tubers under normal growth conditions were created.

[0016] IT1 is a TB-class TCP transcription factor, and the reported functions of its homologous genes in crops such as Arabidopsis thaliana and maize are to regulate plant branching. After the function is lost, the branching of plants can be increased. The regulation of tuber development by IT1 is first discovered in this application. The loss of its function can cause the stolons of potato to not develop into tubers but grow upward to form new plants. This phenotype is reported for the first time in potato and is an identity gene of tubers. In applications, the formation, formation time and size of potato tubers can be controlled by regulating the protein function, expression level, etc. of IT1.

[0017] The nucleotide sequences of IT1 are not necessarily exactly the same in different potato materials. The present invention provides the nucleotide sequences of IT1 in 44 other potato materials obtained during the research process. Their CDS sequences have 94.6% - 100% similarity with the sequence shown in SEQ ID NO: 1 (see Table 1 for details). The sequences that are not exactly the same are shown in SEQ ID NO: 10 - SEQ ID NO: 39; their Genomic sequences have 91.8% - 100% similarity with the sequence shown in SEQ ID NO: 3 (see Table 1 for details). The sequences that are not exactly the same are shown in SEQ ID NO: 66 - SEQ ID NO: 96.

[0018] In the present invention, a nucleotide sequence having less than 75% identity with the nucleotide sequence shown in SEQ ID NO: 1 but having the same function as the gene shown in SEQ ID NO: 1 is also within the protection scope of the present invention.

[0019] In the present invention, genes having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity with the nucleotide sequence shown in SEQ ID NO: 1 and having the same function are all within the protection scope of the present invention.

[0020] In some embodiments, genes having 60 - 70%, 75 - 85%, 76 - 86%, 77 - 87%, 78 - 88%, 79 - 89%, 80 - 90%, 81 - 91%, 82 - 92%, 83 - 93%, 84 - 94%, 85 - 95%, 86 - 96%, 87 - 97%, 88 - 98%, 89 - 99%, 90 - 95%, 91 - 96%, 92 - 97%, 93 - 98%, 94 - 99%, 95 - 100%, 85 - 90%, 86 - 91%, 87 - 92%, 88 - 93% or 89 - 94% identity with the nucleotide sequence shown in SEQ ID NO: 1 and having the same function are all within the protection scope of the present invention.

[0021] Among them, the nucleotide sequence molecule can be DNA, such as cDNA, genomic DNA or recombinant DNA; the nucleotide sequence molecule can also be RNA, such as mRNA or hnRNA, etc.

[0022] Those of ordinary skill in the art can easily mutate the nucleotide sequence encoding the protein of the present invention using known methods, such as directed evolution and point mutation methods. Those artificially modified nucleotides having 75% or higher identity with the nucleotide sequence isolated from the present invention, as long as they encode the protein, are derived from the nucleotide sequence of the present invention and are equivalent to the sequence of the present invention.

[0023] Optionally, the polynucleotide of the present invention further comprises a promoter operably linked to the above nucleotide sequence, wherein the promoter initiates the transcription of the nucleic acid sequence in plant cells, preferably in stolons.

[0024] Specifically, the promoter can be the nucleotide sequence shown in SEQ ID NO: 9, or a polynucleotide having 75% or more identity with the nucleotide shown in SEQ ID NO: 9.

[0025] In the present invention, genes having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity with the nucleotide sequence shown in SEQ ID NO: 9 and having the same function are within the scope of protection of the present invention.

[0026] In some embodiments, genes having 60 - 70%, 75 - 85%, 76 - 86%, 77 - 87%, 78 - 88%, 79 - 89%, 80 - 90%, 81 - 91%, 82 - 92%, 83 - 93%, 84 - 94%, 85 - 95%, 86 - 96%, 87 - 97%, 88 - 98%, 89 - 99%, 90 - 95%, 91 - 96%, 92 - 97%, 93 - 98%, 94 - 99%, 95 - 100%, 85 - 90%, 86 - 91%, 87 - 92%, 88 - 93% or 89 - 94% identity with the nucleotide sequence shown in SEQ ID NO: 9 and having the same function are within the scope of protection of the present invention.

[0027] The present invention provides the promoter regions of the nucleotide sequences of IT1 in 44 other potato materials obtained during the research process, which have 90% - 100% similarity with the sequence shown in SEQ ID NO: 9 respectively (specifically shown in Table 1), and the sequences that are not completely the same are shown in SEQ ID NO: 97 - SEQ ID NO: 131.

[0028] In the present invention, nucleotide sequences having less than 75% identity with the nucleotide sequence shown in SEQ ID NO: 9, but capable of initiating the transcription of the above IT1 nucleic acid sequence, are also within the scope of protection of the present invention.

[0029] As used herein, the term "identity" refers to sequence similarity to a native nucleic acid sequence or amino acid sequence. Identity can be evaluated by the naked eye or by computer software. Using computer software, the identity between two or more sequences can be expressed as a percentage (%), which can be used to evaluate the identity between related sequences.

[0030] On the one hand, the present invention also provides an application of a protein in regulating the development of plant tubers, and the protein is at least one of the following sequences:

[0031] 1) The protein shown in SEQ ID NO: 2;

[0032] 2) A fusion protein obtained by connecting a tag to the N-terminus and / or C-terminus of the protein shown in SEQ ID NO: 2;

[0033] 3) A protein with the same function obtained by substitution and / or deletion and / or addition of one or several amino acid residues in the amino acid sequence shown in SEQ ID NO: 2;

[0034] 4) A protein having 75% or more identity with the amino acid sequence shown in SEQ ID NO: 2 and having the same function.

[0035] In the present invention, proteins having less than 75% identity with the amino acid sequence shown in SEQ ID NO: 2, but having the same function as the protein shown in SEQ ID NO: 2, are also within the scope of protection of the present invention.

[0036] In the present invention, proteins having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity with the amino acid sequence shown in SEQ ID NO: 2 and having the same function are all within the scope of protection of the present invention.

[0037] In some embodiments, proteins having 60 - 70%, 75 - 85%, 76 - 86%, 77 - 87%, 78 - 88%, 79 - 89%, 80 - 90%, 81 - 91%, 82 - 92%, 83 - 93%, 84 - 94%, 85 - 95%, 86 - 96%, 87 - 97%, 88 - 98%, 89 - 99%, 90 - 95%, 91 - 96%, 92 - 97%, 93 - 98%, 94 - 99%, 95 - 100%, 85 - 90%, 86 - 91%, 87 - 92%, 88 - 93% or 89 - 94% identity with the amino acid sequence shown in SEQ ID NO: 2 and having the same function are all within the scope of protection of the present invention.

[0038] The present invention provides the amino acid sequences of IT1 in 44 other potato materials obtained during the research process, which have 92.9% - 100% similarity with the sequence shown in SEQ ID NO: 2 respectively (see Table 1 for details), and the sequences that are not completely the same are shown in SEQ ID NO: 40 - SEQ ID NO: 65.

[0039] Table 1 Comparison of the similarity of IT1 nucleotide, amino acid and promoter sequences in different potato materials

[0040]

[0041]

[0042] On the one hand, the present invention also provides a biological material, which is any one of the following 1) to 9):

[0043] 1) An expression cassette containing the above polynucleotide;

[0044] 2) A recombinant vector containing the above polynucleotide;

[0045] 3) A recombinant microorganism containing the above polynucleotide;

[0046] 4) A plant cell line containing the above polynucleotide;

[0047] [[ID=3,0]]5) A knockout cassette for knocking out the above polynucleotide;

[0048] 6) A knockout vector for knocking out the above polynucleotide;

[0049] 7) A recombinant microorganism for knocking out the above polynucleotide;

[0050] 8) A plant cell line for knocking out the above polynucleotide;

[0051] 9) Plant protoplasts, cells or callus into which any one of 1) - 3) or 5) - 7) is introduced.

[0052] In the present invention, the plant cell line may or may not include propagation materials.

[0053] On the one hand, the present invention also provides the use of the above-mentioned biological material in regulating the development of plant tubers.

[0054] In the specific embodiments provided by the present invention, regulating the development of plant tubers includes regulating one or more of whether tubers are formed, the tuber formation time, the number of tubers, or the size of tubers.

[0055] In the specific embodiments provided by the present invention, the plant is a tuberous plant.

[0056] In the embodiments provided by the present invention, the tuberous plants are selected from potato, sweet potato, cassava, yam, taro, Jerusalem artichoke, Pinellia ternata, or Stachys sieboldii. However, the tuberous plants are not limited thereto, and all tuberous plants considered feasible by those skilled in the art are within the protection scope of the present invention.

[0057] In the specific embodiments provided by the present invention, the tuberous plant is potato.

[0058] The present invention also provides a cultivation method for tuberous plants, in which the above-mentioned polynucleotide or protein is overexpressed in a recipient plant to obtain a target plant; compared with the recipient plant, the tuber formation time of the target plant is advanced, the number of tubers is increased, the tubers are enlarged, and / or the tuber yield is increased.

[0059] In some embodiments, the tuber formation time of the target plant is at least 30% earlier than that of the recipient plant. In some embodiments, the tuber formation time of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% earlier than that of the recipient plant. In some embodiments, the tuber formation time of the target plant is at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 30 days, or at least 40 days, at least 50 days, or at least 60 days earlier than that of the recipient plant.

[0060] In some embodiments, the number, size, or yield of tubers of the target plant is at least 30% higher than that of the recipient plant. In some embodiments, the number, size, or yield of tubers of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% higher than that of the recipient plant. In some embodiments, the number of tubers of the target plant is at least 1, at least 2, at least 3, at least 5, at least 10, or at least 20 higher than that of the recipient plant. In some embodiments, the size of tubers of the target plant is at least 5 g, at least 10 g, at least 15 g, at least 20 g, at least 30 g, at least 50 g, at least 80 g, or at least 100 g higher than that of the recipient plant. In some embodiments, the average tuber yield per plant of the target plant is at least 50 g, at least 100 g, at least 150 g, at least 200 g, at least 300 g, at least 500 g, at least 800 g, or at least 1000 g higher than that of the recipient plant.

[0061] In the specific embodiments provided by the present invention, the methods for overexpressing the above-mentioned polynucleotide or protein in the recipient plant include one or more of promoter editing technology, codon optimization, using a strong promoter, inserting an intron, using a viral vector, and fusion protein technology.

[0062] In some embodiments, the overexpression methods include the following optional methods:

[0063] A. Achieving the purpose of overexpression by various methods of promoter editing technology. The promoter editing technology includes the following optional methods: a. Small-scale changes (base deletion or insertion, but all operations are performed on the original endogenous promoter) of the endogenous promoter (Rodriguez-Leal et al., 2017): Using the CRISPR / Cas9 technology to design all sequences covering the promoter region, and the finally changed promoter sequence will affect the binding ability of transcription factors and thus affect the expression of downstream genes; some promoters contain uORFs encoding small peptides, and the transcription of uORFs during the transcription process of gene expression will affect the transcription of downstream genes and thus affect the expression of downstream genes. Using the CRISPR / Cas9 technology to change these uORFs can also change the expression of downstream genes. b. Inserting elements with the function of enhancing gene expression, such as enhancers, into the original endogenous promoter using the CRISPR / Cas technology to enhance gene expression. c. Directly replacing the endogenous promoter corresponding to the gene: First, using the knock-in method to replace the endogenous promoter with a strong promoter (such as 35S, or a constitutively strong expression promoter); second, using the CRISPR / Cas9 technology to induce chromosomal inversion, so that the promoters of different genes are swapped, resulting in an increase in the expression of the target gene (Schwartz et al., 2020)

[0064] B. Use transgenic methods to introduce the DNA sequence encoding the target gene into the cell. The following methods can be used individually or in combination: First, change the DNA sequence corresponding to the endogenous gene through codon optimization; Second, use a strong promoter (constitutive strong promoters achieve the purpose of overexpression in all tissues, and tissue-specific promoters achieve the purpose of overexpression in specific tissues); Third, certain introns can enhance gene expression, and inserting these introns into the target gene can enhance the expression of the target gene (Gallegos and Rose, 2019); Fourth, fuse certain solubility-promoting or anti-degradation tags or protein sequences to the end of the target gene to enhance the expression of the target protein or prevent its degradation.

[0065] C. Use viral vectors (DNA viruses and RAN viruses) to overexpress the target gene (Torti et al., 2021). The virus will replicate in large quantities in plant cells, thereby greatly increasing the copy number of the target gene and achieving the purpose of overexpression.

[0066] D. Other ways to achieve the purpose of overexpression.

[0067] On the one hand, the present invention also provides a method for cultivating tuber plants, which inhibits the expression of the above-mentioned polynucleotides or proteins in the recipient plant, or inactivates the above-mentioned proteins in the recipient plant, to obtain the target plant; compared with the recipient plant, the target plant does not form tubers, or the tuber formation time of the target plant is delayed, the number of tubers is reduced, the tubers are smaller and / or the tuber yield is reduced.

[0068] In some embodiments, the tuber formation time of the target plant is at least 30% later than that of the recipient plant. In some embodiments, the tuber formation time of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% later than that of the recipient plant. In some embodiments, the tuber formation time of the target plant is at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 30 days, at least 40 days, at least 50 days, or at least 60 days later than that of the recipient plant.

[0069] In some embodiments, the number of tubers, the size of tubers, or the tuber yield of the target plant is at least 30% lower than that of the recipient plant. In some embodiments, the number of tubers, the size of tubers, or the tuber yield of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% lower than that of the recipient plant. In some embodiments, the number of tubers of the target plant is at least 1, at least 2, at least 3, at least 5, at least 10, or at least 20 less than that of the recipient plant. In some embodiments, the size of tubers of the target plant is at least 5 g, at least 10 g, at least 15 g, at least 20 g, at least 30 g, at least 50 g, at least 80 g, or at least 100 g lower than that of the recipient plant. In some embodiments, the average tuber yield per plant of the target plant is at least 50 g, at least 100 g, at least 150 g, at least 200 g, at least 300 g, at least 500 g, at least 800 g, or at least 1000 g lower than that of the recipient plant.

[0070] In the specific embodiments provided by the present invention, the methods for inhibiting the expression of the above-mentioned polynucleotide or protein in the recipient plant and inactivating the above-mentioned protein in the recipient plant include one or more of CRISPR / Cas9 gene editing technology, TALEN technology, T-DNA insertion, EMS mutagenesis, and ZFN technology. Other methods that can achieve expression inhibition or inactivation can also be selected.

[0071] On the one hand, the present invention also provides a tuberous plant, its plant part, tuber or tuber part, or its plant cell, pollen or seed, which is characterized by being one of the following:

[0072] 1) A plant grown from the plant cell line, plant protoplast, cell or callus described above, its plant part, tuber or tuber part, or its plant cell, pollen or seed; or a plant obtained by the cultivation method described in any one of the above, its plant part, tuber or tuber part, or its plant cell, pollen or seed;

[0073] 2) The offspring formed by self-crossing of the plant in 1) above, and the plant grown from the offspring, its plant part, tuber or tuber part, or its plant cell, pollen or seed;

[0074] 3) The offspring formed by cross-breeding of the plant in 1) above with other varieties, and the plant grown from the offspring, its plant part, tuber or tuber part, or its plant cell, pollen or seed.

[0075] On the one hand, the present invention also provides a food or feed made from the plant described above, its plant part, tuber or tuber part, or its plant cell, pollen or seed.

[0076] In one aspect, the present invention also provides a method for manufacturing commercial plant products, which includes obtaining the plant, its plant parts, tubers or tuber parts described in any one of the above, and manufacturing the commercial plant products therefrom, wherein the plant products are selected from the group consisting of: fresh tuber materials, frozen tuber materials, dehydrated tuber materials, tuber liquids, tuber strips, tuber slices, tuber granules and tuber powders.

[0077] In one aspect, the present invention also provides the application of the above biological materials in regulating the development of potato tubers.

[0078] In the specific embodiments provided by the present invention, the above polynucleotides, proteins or biological materials are used to regulate the development of potato tubers. However, the plant is not limited to potatoes, and other plants that can achieve the regulation of tuber development through the technical solutions of the present invention are also within the protection scope of the present invention.

[0079] Furthermore, the potatoes include diploid potatoes, triploid potatoes, tetraploid potatoes or other polyploid potatoes.

[0080] In some embodiments, the potatoes are selected from the group consisting of: potato lines NCIMB41663, NCIMB 41664, NCIMB 41665, NCIMB 41765, NCIMB 43636, Favorita, Qingshu 9, Kexin 1, Jizhangshu 12, Mira, Weiyu 3, Longshu 7, Weiyu 5, E-potato 5, Atlantic, Lishu 6, Longshu 10, Longshu 3, Zhongshu 5, Jinshu 16, Hezuo 88, Zaodabai, Jizhangshu 8, Dongnong 303, Zhuangshu 3, Zhongshu 3, Xingjia 2, Xishen 6 and Hui-2.

[0081] In the embodiments provided by the present invention, regulating the development of potato tubers includes regulating one or several of whether potato tubers are formed, the time of tuber formation, the number of tubers or the size of tubers.

[0082] In one aspect, the present invention also provides a method for cultivating potato plants, which overexpresses the above polynucleotides or proteins in recipient plants to obtain target plants; compared with the recipient plants, the target plants have earlier tuber formation time, increased number of tubers, enlarged tubers and / or increased tuber yield.

[0083] In some embodiments, the overexpression method is the same as described above, and any one or more of the methods can be selected, or other methods that can achieve the purpose of overexpression.

[0084] In some embodiments, the tuber formation time of the target plant is at least 30% earlier than that of the recipient plant. In some embodiments, the tuber formation time of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% earlier than that of the recipient plant. In some embodiments, the tuber formation time of the target plant is at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 30 days, at least 40 days, at least 50 days, or at least 60 days earlier than that of the recipient plant.

[0085] In some embodiments, the number, size, or yield of tubers of the target plant is at least 30% higher than that of the recipient plant. In some embodiments, the number, size, or yield of tubers of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% higher than that of the recipient plant. In some embodiments, the number of tubers of the target plant is at least 1, at least 2, at least 3, at least 5, at least 10, or at least 20 more than that of the recipient plant. In some embodiments, the size of the tubers of the target plant is at least 5 g, at least 10 g, at least 15 g, at least 20 g, at least 30 g, at least 50 g, at least 80 g, or at least 100 g larger than that of the recipient plant. In some embodiments, the average tuber yield per plant of the target plant is at least 50 g, at least 100 g, at least 150 g, at least 200 g, at least 300 g, at least 500 g, at least 800 g, or at least 1000 g higher than that of the recipient plant.

[0086] On the one hand, the present invention also provides another method for cultivating a potato plant, which inhibits the expression of the above-mentioned polynucleotide or protein in the recipient plant, or inactivates the above-mentioned protein in the recipient plant to obtain the target plant; compared with the recipient plant, the target plant does not form tubers, or the tuber formation time of the target plant is postponed, the number of tubers is reduced, the size of the tubers is reduced, and / or the yield of the tubers is reduced.

[0087] In some embodiments, the manner of inhibiting the expression of the above-mentioned polynucleotide or protein in the recipient plant and inactivating the protein in the recipient plant is the same as described above, and any one or more of the above methods can be selected, or other methods that can achieve inhibition of expression or inactivation can be used.

[0088] In a specific embodiment provided by the present invention, the method for suppressing the expression of the above polynucleotide or protein in the recipient plant and inactivating the protein in the recipient plant is the CRISPR / Cas9 gene editing technology. The specific steps of the CRISPR / Cas9 gene editing technology are as follows: using the gene as a target, designing a sgRNA sequence based on CRISPR / Cas9, ligating the DNA fragment encoding the sgRNA sequence into a vector carrying CRISPR / Cas9, transforming the recipient plant, and then obtaining the target plant with the gene function deleted.

[0089] In some embodiments, the tuber formation time of the target plant is at least 30% later than that of the recipient plant. In some embodiments, the tuber formation time of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% later than that of the recipient plant. In some specific embodiments, the tuber formation time of the target plant is at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 30 days, at least 40 days, at least 50 days, or at least 60 days later than that of the recipient plant.

[0090] In some embodiments, the number of tubers, the size of tubers, or the tuber yield of the target plant is at least 30% lower than that of the recipient plant. In some specific embodiments, the number of tubers, the size of tubers, or the tuber yield of the target plant is at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% lower than that of the recipient plant. In some embodiments, the number of tubers of the target plant is at least 1, at least 2, at least 3, at least 5, at least 10, or at least 20 less than that of the recipient plant. In some specific embodiments, the size of tubers of the target plant is at least 5 g, at least 10 g, at least 15 g, at least 20 g, at least 30 g, at least 50 g, at least 80 g, or at least 100 g lower than that of the recipient plant. In some specific embodiments, the average tuber yield per plant of the target plant is at least 50 g, at least 100 g, at least 150 g, at least 200 g, at least 300 g, at least 500 g, at least 800 g, or at least 1000 g lower than that of the recipient plant.

[0091] On the one hand, the present invention also provides a potato plant, its plant parts, tubers or tuber parts, or its plant cells, pollen or seeds, characterized in that it is one of the following:

[0092] 1) Potato plants grown from the plant cell lines, plant protoplasts, cells or calli described above, their plant parts, tubers or tuber parts, or their plant cells, pollen or seeds; or potato plants obtained by the cultivation methods described in any one of the above, their plant parts, tubers or tuber parts, or their plant cells, pollen or seeds;

[0093] 2) The offspring formed by self - crossing of the plants in 1) above, and the potato plants grown from the offspring, their plant parts, tubers or tuber parts, or their plant cells, pollen or seeds;

[0094] 3) The offspring formed by crossing the plants in 1) above with other varieties, and the potato plants grown from the offspring, their plant parts, tubers or tuber parts, or their plant cells, pollen or seeds.

[0095] On the one hand, the present invention also provides foods or feeds made from the potato plants described above, their plant parts, tubers or tuber parts, or their plant cells, pollen or seeds.

[0096] The present invention also provides a method for manufacturing commercial plant products, which includes obtaining the potato plants described in any one of the above, and manufacturing the commercial plant products from their plant parts, tubers or tuber parts, wherein the plant products are selected from the group consisting of: fresh potatoes, frozen potatoes, dehydrated potatoes, potato juice, potato strips, potato chips, potato granules, potato flour and potato starch.

[0097] Compared with the prior art, the technical effects of the present invention are as follows:

[0098] Before the present invention, research progress related to potato tuber development mainly focused on the molecular mechanism analysis of the combined action of plant endogenous signals and external environments, such as:

[0099] Endogenous plant hormones are important signaling factors that regulate tuber formation. GA-20 oxidase (GA20OX) is a dioxygenase that can catalyze multiple oxidation reactions to ultimately promote the synthesis of gibberellin. In 1999, Carrera et al. first cloned three gibberellin oxidase genes (StGA20OX1-3) from potato. Their research showed that overexpression of these genes in potato could delay tuberization, while inhibiting their expression could accelerate tuberization and increase yield (Carrera et al., 2000, 1999). Further research by Kloosterman et al. showed that the StGA20OX1 gene regulates potato tuber formation by controlling the content of GA in the sub-apical region of stolons (Kloosterman et al., 2007). GA-2 oxidase (GA2OX) is a key enzyme in the third stage of the gibberellin synthesis pathway. It can convert active gibberellin into inactive gibberellin, thus inhibiting the synthesis of gibberellin. Overexpression of StGA2OX1 in potato inhibits the growth of stolons and promotes early tuberization, while inhibiting its expression delays tuberization (Kloosterman et al., 2007). Therefore, it can be inferred that GA promotes the growth of stolons and inhibits tuber formation during potato tuber development. Cytokinin oxidase / dehydrogenase (CKX) is a flavoenzyme that can degrade cytokinin into adenine / adenosine. Overexpression of CKX1 in potato reduces the number of tubers per plant and thus affects yield (Hartmann et al., 2011). TLOG1 is a cytokinin synthesis gene in tomato. Ectopic expression of this gene in tomato can relieve the inhibition of tuber formation by axillary meristems, resulting in the formation of small tubers at the axillary buds at the base (Eviatar-Ribak et al., 2013; Abelenda and Prat, 2013). These results suggest that cytokinin is likely to be a broad-spectrum regulator of storage organ formation in plants. In addition, in addition to gibberellin and cytokinin, it has also been reported that hormones such as auxin, strigolactone, and abscisic acid also play important roles in potato tuber formation (Navarro et al., 2015).

[0100] In addition, the external growth environment also plays an important role in potato tuber formation, among which the photoperiod has the most obvious effect on tuber formation. Potatoes originated in the regions of Peru and Bolivia in the central western foothills of the Andes Mountains in South America, on the verge of the Pacific Ocean. In its place of origin, short-day can induce the formation of potato tubers, while long-day inhibits tuberization. The photoperiod is a key environmental factor in potato tuber morphogenesis. Research results in recent years have shown that some regulatory elements involved in the flowering pathway, such as phytochrome B (PHYB), CONSTANS (CO), FLOWERING LOCUS T (FT), CDF transcription factors, etc., also play important roles in the potato tuber formation pathway.

[0101] PHYB is an important photoreceptor regulating potato tuber development. Downregulation of its expression significantly enhances the tuberization ability of plants under long-day conditions. PHYB is mainly expressed in leaves. Grafting plants with significantly downregulated PHYB expression in the above-ground part as the scion onto wild plants as the rootstock can still rapidly form tubers under long-day conditions, indicating that PHYB can sense light signals in leaves and inhibit tuber formation under long-day conditions (Jackson et al., 1998). CONSTANS (CO) is a key factor regulating flowering in Arabidopsis. Overexpression of AtCO in potato can delay tuber formation in potato plants grown under short-day conditions by more than 7 weeks. StCO has a similar function to AtCO, and overexpression of StCO in potato can also delay tuber formation. Further grafting experiment results show that grafting the upper part of AtCO- or StCO-overexpressing plants onto wild-type potato can significantly delay tuber formation, while the reverse does not affect tuber development, indicating that CONSTANS (CO) negatively regulates potato tuberization through its expression in leaves (Martínez-García et al., 2002; González-Schain et al., 2012). CDFs proteins are members of the DOF transcription factor family and are a class of transcriptional repressors. In Arabidopsis, they can directly bind to the promoter regions of CO and FT to inhibit plant flowering. StCDF1, the homologous protein of AtCDFs in potato, can also regulate the expression of StCO, and its protein content is jointly regulated by the LOV blue-light receptor protein StFKF1 and the core circadian clock protein StGI. In potato, when the domain where StCDF1 interacts with StFKF1 and StGI mutates, the protein amount of StCDF1 can accumulate, thus promoting early tuber formation (Kloosterman et al., 2013). Early studies found that grafting flowering tobacco stem segments onto potato can effectively induce potato tuber formation, indicating that there is likely tuberigen in the leaves or stem segments of flowering plants that can induce potato tuber formation (Chailakhyan et al., 1981).The FLOWERING LOCUS T (FT) protein in Arabidopsis thaliana and the Hd3a protein in rice have been identified as a class of florigens that can induce plant flowering. Overexpression of Hd3a in potato can induce normal tuber formation even under long-day conditions, indicating that the tuberigen in potato is likely also an FT-like protein. There are four FT-like genes in potato, namely StSP6A, StSP5G, StSP5G-like, and StSP3D. Among them, StSP6A is mainly expressed in leaves under short-day conditions. Its overexpression can induce normal tuber formation in plants under long-day conditions, and inhibition of its expression will delay tuber formation. Grafting experiments have demonstrated that it can be synthesized in leaves and transported over long distances to stolons. These results all prove that StSP6A is the tuberigen in potato. In addition, studies have found that StSP3D can independently control plant flowering, while StSP5G can inhibit tuber formation by suppressing the expression of StSP6A (Navarro et al., 2011; Abelenda et al., 2016).

[0102] However, in the research on genes regulating potato tuber formation, there has been no report that mutation of a certain gene can prevent the stolons of potato from further developing into tubers.

[0103] The present invention discovers that IT1 is a key gene controlling tuber formation. In application, the formation, formation time, and size of potato tubers can be controlled by regulating the protein function, expression level, etc. of IT1. Further, the formation, formation time, and the size, number, and yield of tubers of other tuberous plants can be regulated by regulating the protein function, expression level, etc. of IT1. BRIEF DESCRIPTION OF THE DRAWINGS

[0104] Figure 1 Showing the genotype of the homozygous mutant line of the potato IT1 gene; compared with the wild type, a 1bp base is inserted in the mutant line, which is a loss-of-function mutant;

[0105] Figure 2 Showing the phenotypic identification results of the homozygous mutant line of the potato IT1 gene; compared with the wild-type plant (WT), the stolons of the homozygous mutant line of the IT1 gene (it1) did not further swell and develop into tubers after the apical hook, but grew upward and developed into a new plant, as shown at the position indicated by △ in Figure 2-2 ; Figure 2-1 and Figure 2-2 The scale bars in FIGS. and are 10 cm, Figure 2 and the scale bar in -3 is 5 cm. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0106] The present invention discloses the applications of polynucleotides, proteins, and biomaterials in regulating plant tuber development, as well as related products and cultivation methods. Those skilled in the art can draw on the content of this article and appropriately modify the process parameters to achieve the same. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are all considered to be included in the present invention. The methods and applications of the present invention have been described through preferred embodiments. Relevant personnel can obviously make changes, or make appropriate alterations and combinations, to the methods and applications described herein without departing from the content, spirit, and scope of the present invention, so as to implement and apply the technology of the present invention.

[0107] Glossary of terms:

[0108] N-terminus: Refers to the amino terminus of a peptide chain or protein;

[0109] C-terminus: Refers to the carboxyl terminus of a peptide chain or protein;

[0110] cDNA: Full name is complementary DNA, which is a kind of complementary deoxyribonucleic acid;

[0111] CRISPR / Cas9 system: CRISPR / Cas9 is an adaptive immune defense formed by bacteria and archaea during long-term evolution and can be used to combat invading viruses and foreign DNA. The CRISPR / Cas9 system integrates fragments of invading phage and plasmid DNA into CRISPR and uses the corresponding CRISPR RNAs (crRNAs) to direct the degradation of homologous sequences, thereby providing immunity. The working principle of this system is that crRNA (CRISPR-derived RNA) forms a tracrRNA / crRNA complex by base pairing with tracrRNA (trans-activating RNA). This complex guides the nuclease Cas9 protein to cleave double-stranded DNA at the sequence target site paired with crRNA. By artificially designing these two RNAs, a guiding sgRNA (single-guide RNA) can be modified to be sufficient to guide Cas9 to perform site-directed cleavage of DNA;

[0112] TALEN: Transcription activator-like effector nuclease;

[0113] T-DNA: (Transfer DNA), also known as triple helix DNA, is a special deoxyribonucleotide structure formed by the rotation of three strands of ssDNA;

[0114] EMS mutagenesis: It is an artificial chemical mutagenesis technique. EMS is ethyl methanesulfonate, which is one of the most commonly used alkylating agents for mutagenesis and has a very high mutagenesis rate;

[0115] ZFN: Zinc-finger nuclease (ZFN), also known as zinc-finger protein nuclease (ZFPN), is a class of artificially synthesized restriction endonucleases formed by fusing the zinc-finger DNA-binding domain with the DNA cleavage domain of restriction endonucleases. Researchers can modify the zinc-finger DNA-binding domain of ZFN to target different DNA sequences, enabling ZFN to bind to the target sequence in a complex genome and perform specific cleavage by the DNA cleavage domain. Currently, in a large number of species such as plants, Drosophila, zebrafish, frogs, rats / mice, and cattle, the ZFN technology has been widely used for targeted gene mutation, and new species with modified genetic backgrounds can be generated by artificially modifying genomic information;

[0116] TCP transcription factor: It is a transcription family unique to higher plants, named after the initials of the three isolated members, Teosinte branched1 (TB1), Cycloidea (CYC), and Proliferating cell factors (PCFs).

[0117] sgRNA (small guide RNA): It is a guide RNA that guides the insertion or deletion of uridine residues into kinetoplasts during RNA editing. It belongs to a type of small non-coding RNA and can pair with pre-mRNA. The gRNA edits RNA molecules, with a length of approximately 60 - 80 nucleotides, and is transcribed from a separate gene;

[0118] WT: The abbreviation of wild type, that is, wild type;

[0119] CDS sequence: CDS is the abbreviation of Coding sequence. DNA is transcribed into mRNA, and after mRNA is spliced and processed, it is translated into protein. The so-called CDS is the DNA sequence that corresponds one-to-one with the protein sequence, and there is no other sequence in the middle that does not correspond to this protein, without considering the sequence changes during mRNA processing, etc. [[ID=1,7]]

[0120] Sanger sequencing: The Sanger method starts from a fixed point for nucleotides, randomly terminates at a specific base, and performs fluorescence labeling behind each base to generate a series of nucleotides of different lengths ending with A, T, C, and G. Then, it is detected by electrophoresis on a urea-denatured PAGE gel to obtain the visible DNA base sequence.

[0121] In the following embodiments, the experimental methods are conventional methods unless otherwise specified.

[0122] The biomaterials, sequences, reagents or instruments used in the embodiments of the present invention can be obtained commercially.

[0123] Note: In this application, the IT1 gene is the abbreviation of Identity of Tuber 1 gene, including the Soltu.DM.06G025210.1 gene and / or its homologous genes.

[0124] Whether IT1 or IT1 represents a gene or a protein can be determined according to the context.

[0125] The present invention will be further described below in conjunction with embodiments:

[0126] Example 1 Knockout of the IT1 gene using the CRISPR / Cas9 system

[0127] The IT1 gene in potato was knocked out using the CRISPR / Cas9 system to obtain a potato mutant with the IT1 gene knocked out. The specific steps are as follows:

[0128] Step 1. Selection of the sgRNA sequence

[0129] A target site sequence with a length of 20 bp was designed on the IT1 gene.

[0130] Sequence 1 (CDS of the IT1 gene) is shown as SEQ ID NO:1, sequence 2 (protein) is shown as SEQ ID NO:2, and sequence 3 (genome) is shown as SEQ ID NO:3.

[0131] The target site is located at positions 308-327 of sequence 1 (CDS sequence) and at positions 720-739 of sequence 3 (genomic sequence). The target site 1 sequence is GAATTAGTATTATTAGTGGA (sequence 4, SEQ ID NO:4).

[0132] The designed sgRNA sequence for the target site is:

[0133] GUUUUAGAGCUAGAAAUAGCAAGUUAAAAUAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGC (sequence 5, SEQ ID NO:5)

[0134] The coding DNA molecule of this sgRNA is:

[0135] GTTTTAGAGCTAGAAATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAACTTGAAAAAGTGGCACCGAGTCGGTGC (Sequence 6, SEQ ID NO:6).

[0136] Step 2. Construction of the CRISPR / Cas9 vector

[0137] The original vector contains the sgRNA sequence. Further, the target site 1 sequence in Step 1 is inserted into the vector to obtain the CRISPR / Cas9 vector.

[0138] Step 3. Obtaining of transgenic plants

[0139] The CRISPR / Cas9 vector obtained in Step 2 is transferred into the competent Agrobacterium tumefaciens cells EHA105 (the competent Agrobacterium tumefaciens cells EHA105 are purchased from Shanghai Weidi Biotechnology Co., Ltd. and can be obtained by the public through purchase) by heat shock transformation to obtain the recombinant bacteria EHA105 / CRISPR / Cas9.

[0140] Then, the recombinant bacteria EHA105 / CRISPR / Cas are used to transform potatoes by the Agrobacterium - mediated transformation method (the recombinant Agrobacterium is propagated at 28 °C, and the propagated bacterial liquid is used for potato infection). After kanamycin resistance screening, the T0 generation transgenic potato plants are obtained.

[0141] Example 2 Identification of transgenic plants with mutated IT1 gene

[0142] Collect the leaves of the T0 generation transgenic potato plants obtained in Step 3 of Example 1, and extract the genomic DNA as a template. PCR amplification is carried out using the following primer pairs to obtain the PCR amplification products of different strains.

[0143] The sequences of the IT1 mutation sequence detection primers are as follows:

[0144] IT1 - test - F: AGCTACAGCTACTGCGCAAA (Sequence 7, SEQ ID NO:7)

[0145] IT1 - test - R: AGTAGTGGGGGTATTGCAGC (Sequence 8, SEQ ID NO:8)

[0146] The PCR amplification products of different strains are subjected to Sanger sequencing, and the sequencing results are compared with the wild - type IT1 gene. The IT1 genotypes are identified according to the following principles.

[0147] A sequence with a bimodal feature starting from the target site sequence indicates that the genotype of this strain is a heterozygous genotype (the IT1 gene on one of the two homologous chromosomes is mutated, and the IT1 gene on the other chromosome is not mutated). This strain is a T0 generation transgenic potato heterozygous mutant strain;

[0148] A sequence with a bimodal feature starting from the target site sequence, and the IT1 genes on both homologous chromosomes are mutated, then this strain is a T0 generation transgenic potato biallelic mutant strain.

[0149] A sequence with a specific unimodal feature starting from the target site sequence. If it is the same as the IT1 gene sequence of wild-type potato, then the genotype of this strain is wild-type, that is, the IT1 gene sequence has not mutated; if it is different from the IT1 gene sequence of wild-type potato, then the genotype of this strain is a homozygous genotype (the IT1 genes on both homologous chromosomes are mutated), and this strain is a T0 generation transgenic potato homozygous mutant strain.

[0150] In this case, a T0 generation IT1 gene homozygous mutant strain (as Figure 1 shown) was identified for the identification of the following potato tuber growth phenotypes.

[0151] Example 3 Potato mutants with IT1 gene knockout show abnormal tuber growth and development

[0152] The T0 generation IT1 gene homozygous mutant strain obtained in Example 2 was planted in the greenhouse of the South China Agricultural University Middle-scale Test Base in autumn 2021. Through systematic identification of the tuber-bearing phenotypes of the mutants, it was found that the homozygous mutants of IT1 showed a phenotype that the stolons did not further expand and develop into tubers after bending at the top, but grew upward and developed into a new plant, indicating that IT1 plays a key role in regulating the process of potato tuber formation ( Figure 2 ).

[0153] The sequences 1 - 3 in the above examples are as follows:

[0154] Sequence 1 (CDS):

[0155]

[0156] Sequence 2 (protein):

[0157] MYPPSNNNCNYSPILSSFICQNIPSSPCMQYEHELYFQNFNHDDQYYFQLQQQVPLIDDLSPHVLADSCTETVTKPSNCNHVLEGMEEGRGGNKGDDVVMSSRISIISGRISKNNKRSSNKDRHSKINTARGPRDRRMRLSLDAARKFFRLQDLLGFDKASKTVEWLLTQSDSAIEELVAVKGNDAQVPQQTSCNTPTTTTGIGAICASNSISESCEVISGTDETSSNDKNKETTAKDEKEKKKKPVNTARRPAFEPLTKESRNQARARARERTKTKKMSQVGKSKSPAHDLNPSGSRRPANRTCEEPGTHEQHTFHHVDDSSFVVNGNWNPFTIFTSHEQYAGISNEHQLVTDLQFYGKLWES

[0158] Sequence 3 (genome):

[0159]

[0160] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention. Sequence Listing <110> Shenzhen Institute of Agricultural Genomics, Chinese Academy of Agricultural Sciences Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences <120> Application of polynucleotides, proteins, biological materials in regulating plant tuber development, related products and cultivation methods <130> 22-14035CN <160> 131 <170> SIPOSequenceListing 1.0 <210> 1 <211> 1095 <212> DNA <213> Artificial Sequence <400> 1 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ttctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 2 <211> 364 <212> PRT <213> Artificial Sequence [[ID=!0]]<400> 2 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Pro Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Ala His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Ser Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 3 <211> 1826 <212> DNA <213> Artificial Sequence <400> 3 catgcctgta gcttgatgct tagacgggtg cacacgcact ctctcactca cacagctaga 60 atatatatat atatatatat atatattcat agttagcaga agtacttatc atataccaaa 120 aaccacacaa atacattgta tcaagtgctg tcatactcaa gcaaaagaaa gaaaagaaca 180 agatatagta ctactgtttt catcaccatt ttggtcaatc atgatgattc tgaacaaaga 240 tatagtacta gctaggtaga aaataaatct accaacttta attttcttct tattgcagct 300 agcttgctta attagcagca aaactcaaaa gaggttttag ctgtgtttat actgtctttc 360 tcaagatcta gacccaccac ttagaccatc tcaagctaca gctactgcgc aaatgtatcc 420 tccaagcaac aataactgca actacagccc aattttgtct tctttcatat gccaaaatat 480 tccatcttct ccttgtatgc aatacgaaca cgaactatac tttcaaaact tcaatcatga 540 tgaccaatat tattttcaac tacagcaaca agttcccttg atagatgact tgagtcctca 600 cgtcttagct gacagctgca ctgagactgt tactaagcct tcaaattgca atcacgtact 660 agaaggaatg gaagaaggcc gaggcggaaa caaaggagat gatgttgtta tgagtagcag 720 aattagtatt attagtggac ggatctcgaa aaacaataag agatcttcca ataaggatcg 780 acacagcaag atcaacacgg ctcgtggtcc aagagatcga aggatgagac tttcacttga 840 tgctgctcgc aagtttttcc gtttgcagga cttattggga tttgataagg ccagcaaaac 900 tgtagaatgg ttgcttactc aatcggattc cgcaattgaa gagctcgtcg ccgttaaagg 960 caatgatgct caggttcctc agcaaactag ctgcaatacc cccactacta ctactggaat 1020 tggtgcaatt tgtgcatcta attctatttc tgagtcatgt gaagttatat caggaactga 1080 tgaaacttcc tctaatgaca aaaacaagga aactactgct aaagatgaga aggagaaaaa 1140 gaagaagccg gttaacacag ctcgtagacc tgcgtttgaa cctcttacaa aggaatcaag 1200 gaatcaagca agagccaggg ctagagagag aacaaaaaca aagaaaatga gccaagttgg 1260 aaaatccaaa tccccagctc atgatttgaa cccttcagga tctcggaggc cggctaatag 1320 aacttgtgaa gaacctggaa cacatgaaca acacaccttc catcatgttg atgacagtag 1380 ttttgtggtt aatggaaatt ggaatccatt tacaatcttc acttctcatg aacaatatgc 1440 tggaatttcc aatgaggtga gggcttcaat aattaattaa atccagtaga tttctattta 1500 tatatatata tatatattct tatcagcttc taaaaaaaat ccttatttct ctgcagcatc 1560 aattagttac agacttgcaa ttttatggaa agctgtggga aagctagggc aaggaaattc 1620 gaagcggaca aagttccttc ttcattttgt gcttactcgg ccgagcagaa gaacgtttcc 1680 ggcctgtatc tgttggtaaa tgtaacatac atttctactt tttaagtgtg tttttctttt 1740 gtgaaagaac ttcatgtgca gatagcctat gttttttttt tgaataaaac tatgatgggg 1800 ttcattaagc aagcgacata ttcggg 1826 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <400> 4 gaattagtat tattagtgga 20 <210> 5 <211> 76 <212> RNA <213> Artificial Sequence <400> 5 guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu 60 ggcaccgagu cggugc 76 <210> 6 <211> 76 <212> DNA <213> Artificial Sequence <400> 6 gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt 60 ggcaccgagt cggtgc 76 <210> 7 <211> 20 <212> DNA / RNA <213> Artificial Sequence <400> 7 agctacagct actgcgcaaa 20 <210> 8 <211> 20 <212> DNA / RNA <213> Artificial Sequence <400> 8 agtagtgggg gtattgcagc 20 <210> 9 <211> 3000 <212> DNA <213> Artificial Sequence <400> 9 cacaaatttt ttaggttgcc gatccagaga atttaaatat taatgttgtg aattctaata 60 ctccaaatat taatgttgtg aattctaata ctccacctgt tttaaaaaat ggtctagttt 120 gacttgaaac ggaatttaag aaaagaaaaa agactttcta atcttgtgat gccaaattaa 180 agttatgtca aatataccaa aatgtccttt aatcttgtgc tcttaaacat gtcacgtgaa 240 aaattgaagt taaagtgttg ccaaaaaaag aaaggggtca ttatttttta aacaaactaa 300 aaaaaaaaaa ctaagtcatt ccttttgaaa cggagaaagt atactatatt tatatatttg 360 gttctcgcaa acctgcaaat aagggcggat gcacaataga agttacgagt ttgattaaat 420 ctactaattt tatttaaact ttgtatatat gtgtagagaa gtcataaagt tcaaatactg 480 aatttactaa ttttatcaaa gttgtgatct actgctaatt aaagttgggt gggcaggtgg 540 ggatgccccg tattggggaa tgtagtatac tgtacatcta aaagcaattt tggcaaaacc 600 atctctgtca ctgatctctc acttcacaat actaacatat agagttgggg ccaaagtagt 660 catgtagttg atgggaagag atagtacgga ggaatggaga aaaaggtagg tgggtgagtt 720 gggggaagag atagggttct ctttttagtg aaagtgacat gctctaaggt caaaagttgc 780 attcttctca aagggcaatt cagactttca tcactcccta gtgagggcgc ggagctagat 840 atgcaaaggg tttatataaa tttatgtgat acattttttt tagttaatct aaaatataat 900 aaaagctttt ttttttaaca agatcgattt gaaatcacac aaatatttgt gaatttagat 960 cataaatttc aaaaatcttt taataaaagg ctagcttctg ttcttggcct tttagaggtt 1020 aggtacatgc tccatcccct cctttcttgt tgttactatt tgccatggcc ggtagggatc 1080 agggtcaaac cccaatgtat cacaggtcag tatagtccga ccgtgacaat tttctatggg 1140 ggattgtgta gaatcaaata tctattcata aattgagaca ttgagacgaa tattcttctt 1200 tacattattg agacgaaaaa aatattaaat tttcttaata aaaatcttag ctccccacta 1260 tttagtctag gtttcatatt caatgaattg ctggggttta tgttattact caactgaaat 1320 aaaaagagaa ttgtcgttat ccaggttaga caaaagcacg tgtagtttca aacgcagtag ~1380 ccattattct cctctccttt acaggtgaga ttcaagggca gaaaggtacc atgcaagctg 1440 ttatttaaat ttacttattg attatgatcg acgactttga cagaaaaatg atgatgcttt 1500 aattttacga cctagccttt ctttttaaga agaataaaaa acatacctcg atttggtata 1560 aatcaatagt ttcgtcaatc ttaaaaacat tcctttactt gacttactaa atttaaatat 1620 atcttcgatc tgccacataa cataacaaat ggtttcaaac ggaacatatg actcttaata 1680 aaaggtggag aagggttgaa aactttacta aatttaacaa gatcttaggt gtgtatttga 1740 ctcatgttgc aagattgaag tgtatttaag ttcagttaat caagtaaaga gatattttta 1800 aggttgtcaa tatataattc ggagataaaa ctagcctttt gtttcatttg ttgagtttaa 1860 aattaagttg atatgaaaca acaaataaat tgtgatccca agttttatat gagcaaaata 1920 Note: The "~" in the translation of line 4 is used to represent the approximate position of the original text for better alignment. In actual patent text translation, it should be adjusted according to the specific context and requirements.aaatcaagca ttgtatatct ctcttttatt tttctcccta gtatccgcat tggagcccga 1980 ctatattcga atcgcactat aggcttcatt tttttcatac tcgagtctta aatctgaaac 2040 ctctgggtaa gggtagaata tcttatatct cttttttttt ttttttttgg attttccatt 2100 caacgtttgg tacccacatt gaagttcagt taattcaaat ttgcaccgca taggctaagc 2160 ggttcctacc aatgatcttt tcatacccag ggactcaaac acaagaagtt taattaagaa 2220 ataaatagtc tcatccgcta taccacattg tgatatatct cattaagata ccacattata 2280 tctatttatg ggggtagggg ggatgggtct agctagggtt gtggaaatga ggttagagag 2340 agagtggttt ttcagtgtgt gtgtcaggtg atatcacgtg aaggggcacg ataacaagtt 2400 gttcatatcc attcacttcc aagaataccg ctacgtacag tcactagctg ctttcttcct 2460 atccccatct ttgtcaaatt tcctttcctt ttccaattac tttttcttta atagacatgg 2520 acgcaattct tccttccttt ccccttcccc tatattcttc ctttatctct ctttcacaat 2580 aatagcacca tgcctgtagc ttgatgctta gacgggtgca cacgcactct ctcactcaca 2640 cagctagaat atatatatat atatatatat atattcatag ttagcagaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac caactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 10 <211> 1095 <212> DNA <213> Artificial Sequence <400> 10 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcctc acgtcttagc tgatagctgc actgagactg ttactaagcc ttcaaattgc 240 aatcacgtac tagaaggaat ggaagaaggc cgaggcggaa acaaaggaga tgatgttatg 300[[ID=I]] agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg ttgaatggtt gcttactcaa tcggataccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacacct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagttcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccatata caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 11 <211> 1092 <212> DNA <213> Artificial Sequence <400> 11 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gtaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gataccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcacctc tcatgaacaa 1020 tatgctggaa tttccaatga gcatcaatta gttacagact tgcaatttta tggaaagctg 1080 tgggaaagct ag 1092 <210> 12 <211> 1095 <212> DNA <213> Artificial Sequence <400> 12 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctattgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaatcaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaatc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 13 <211> 1095 <212> DNA <213> Artificial Sequence <400> 13 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaatcaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 14 <211> 1095 <212> DNA <213> Artificial Sequence <400> 14 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tgttgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ttctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 15 <211> 1095 <212> DNA <213> Artificial Sequence <400> 15 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 aatcatgacg accaatatta ttttcaacaa cagcaacaag ttcccttaat agatgacttg 180 agtcctcaca tcttagctga cagctgcacc gagactgtta ctaagccttc aaattgcaat 240 cacgtacaag aaggaatgga agaaggccga ggcggaaaca aaggaggtga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcagat tcctcagcaa actagctgca atactcccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggtaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gaggatcggc taataaaact 900 tgtgaagaac ctggaactca tgaacaacac accttccatc atgagaagaa cagtgtcgat 960 gaaagtaatt ttgtggttaa tggatattgg aatccattta caatcttcag ctatcatgag 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttgtggaaag 1080 ctgtgggaaa gctag 1095 <210> 16 <211> 1092 <212> DNA <213> Artificial Sequence <400> 16 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcaca gagactgtta ctaagccttc aaattgcaat 240 cacgtactcg aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcaccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca atgatttgaa cccttcagga tctcggaggc cggctaatag aacttgtgaa 900 gaagaacctg gaacacatga acaacacacc ttccatcatg agaagaacag tgttaatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccaatga gcatcaatta gttacagact tgcaatttta tggaaagctg 1080 tgggaaagct ag 1092 <210> 17 <211> 1101 <212> DNA <213> Artificial Sequence <400> 17 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttcttttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtg 540 aaaggcaatg atgctcaggt ttctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatccc aagccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag catcaattag ttacagattt gcaattttat 1080 ggaaagctgt gggaaagcta g 1101 <210> 18 <211> 1095 <212> DNA <213> Artificial Sequence <400> 18 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gaaactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga ggaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgcgactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggataccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgaaaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 19 <211> 1095 <212> DNA <213> Artificial Sequence <400> 19 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta tttccaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga tagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcaaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 20 <211> 1101 <212> DNA <213> Artificial Sequence <400> 20 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcgca tcttagctga cagctgcact gagactgtta ctaagcgttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtatttttag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caagacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctacgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacaaatgaa caacacacct tccatcatga caagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag catcaattag ttacagactt gcaattttat 1080 ggaaagctgt gggaaagcta g 1101 <210> 21 <211> 1095 <212> DNA <213> Artificial Sequence <400> 21 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc cgtcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcgtgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacgaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa tttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 22 <211> 1092 <212> DNA <213> Artificial Sequence <400> 22 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacctg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttac tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aacagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccaatga gcatcaatta gttacagact tgcaatttta tggaaagctg 1080 tgggaaagct ag 1092 <210> 23 <211> 1095 <212> DNA <213> Artificial Sequence <400> 23 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc cgtcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgct 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 24 <211> 1095 <212> DNA <213> Artificial Sequence <400> 24 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 ATGTATCCTC CAAGCAACAA TAACTGCAAC TACAGCCCAATTTTGTCTTC TTTTAATATGC 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 CAAAAATATTC CATCTTCTCC TTGTATGCAATATGAACACG AACTATACTT TCAAAACTTC 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ctcccttgat agatgacttg 180 AATCATGATG ACCAATATTA TTTTCAACAA CAGCAACAAG CTCCCTTGAT AGATGACTTG 180 agtcctcaca tcttagctga cagctgcacc gagactgtta ctaagccttc aaattgcaat 240 AGTCCTCACA TCTTAGCTGA CAGCTGCACC GAGACTGTTA CTAAGCCTTC AAATTGC AAT 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 CACGTACTAG AAGGAATGGA AGAAGGCCGA GGCGGAAACA AAGGAGATGA TGTTATGAGT 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 AGCAG AATTA GTATTATTAG TGGA CGGAT CTCA AAAA ATA ATA AGA GATC TTCCA ATA AG 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 GATCGACACA GCAAGATCAA CACC GCTCGT GGTC CAAG AGA TCG AAG GAT GAG ACT TTC A 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggattcga taaggccagc 480 CTTGATGCTG CTCGCAAGTT TTTCCGTTTG CAGGACTTGT TGGGATTCGA TAAGGCCAGC 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 AAAACTGTAG AATGGTTGCT TACTCAATCG GATTCCGCAA TTGAAGAGCT CGTCCGCCGT 540 aaaggcaatg atgctcagat tcctcagcaa actagctgca atacccccac tgctactact 600 AAAGGCAATG ATGCT CAGAT TCCTCAGCAA ACTAGCTGCA ATACCCCCAC TGCTACTACT 600 ggaataggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 GGAATAGGTG CAATTTGTGC ATCTAATTCT ATTTCTGAGT CATGTGAAGT TATATCAGGA 660 actgatgaaa cttcctctaa tgacaaaaac aaggtaactg ctaaagatga gaaggagaaa 720 ACTGATGAAA CTTCC TCTAA TGAC AAAAA CAAG GTAACT GCTAA AGATG AGA AGG AGAA 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gaggatcggc taataaaact 900 tgtgaagaac ctggaactca tgaacaacac accttccatc atgagaagaa cagtgtcgat 960 gaaagtaatt ttgtggttaa tggatattgg aatccattta caatcttcag ttatcatgag 1020 caatatgctg gagtttccaa tgagcatcaa ttagttacag acttgcaatt ttgtggaaag 1080 ctgtgggaaa gctag 1095 <210> 25 <211> 1101 <212> DNA <213> Artificial Sequence <400> 25 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttcccttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cactgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaaatt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaagggaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcatctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagtcaaatt 840 ggaaaatcca aatccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag catcaattag ttacagactt gcaattttat 1080 ggaaagctgt gggaaagcta g 1101 <210> 26 <211> 1095 <212> DNA <213> Artificial Sequence <400> 26 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc gcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 27 <211> 1092 <212> DNA <213> Artificial Sequence <400> 27 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacatg aactatactt tcaaaacttt 120 caaaatattc catcttctcc ttgtatgcaa tatgaacatg aactatactt tcaaaacttt 120 aatcatgatg accattatta ttttcaacaa cagcaacaag ttcccttgat agatgacttg 180 aatcatgatg accattatta ttttcaacaa cagcaacaag ttcccttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcacc gagactgtta ctaagccttc aaactgcaat 240 agtcctcaca tcttagctga cagctgcacc gagactgtta ctaagccttc aaactgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata acaagagatc ttccaataag 360 agcagaatta gtattattag tggacggatc tcaaaaaata acaagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 ctcgatgccg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 ctcgatgccg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaagat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacctttcag gatcggctag taaaacttgt 900 gaagaacctg gaactcatga acaacacaac ttccatcatg agaagatcag tgtcgatgaa 960 agtaattttg ttgttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tgtccaatga gcatcaatta gttacagact tgcagtttta tggaaagctg 1080 tgggaaagct ag 1092 <210> 28 <211> 1101 <212> DNA <213> Artificial Sequence <400> 28 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgacgctg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgta atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag catcaattag ttacagactt gcaattttat 1080 ggaaagctgt gggaaagcta g 1101 <210> 29 <211> 1089 <212> DNA <213> Artificial Sequence <400> 29 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacctg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaagtt 840 ggaaaatcca aatccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatgt tgatgacagt 960 aattttgtgg ttaatggaaa ttggaatcca tttacaatct tcagctctca tgaacaatat 1020 gctggaattt ccagtgagca tcaattagtt acagacttgc aattttatgg aaagctgtgg 1080 gaaagctag 1089 <210> 30 <211> 1203 <212> DNA <213> Artificial Sequence <400> 30 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatattc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 aatcctcaca tcttagctga tagctgcaca gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagagga tgctatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgccg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac aggtcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aatcctcagc tcatgatttg aacccttcag gatctcggag gccggctact 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgagaagaac 960 agtgttgatg acagtaattt tgtggttaat ggaaattgga atccatttac aatcttcagc 1020 tctcatgaac aatatgctgg aatttccaat gagacttgca attttatgga aagctgtggg 1080 aaagctaggg caaggaaatt cgaagcggac aaagttcctt cttcattttg tgcttactcg 1140 gccgagcaga agaacgtttc cggcctgtat ctgttggtaa atgtaacata cattcgtact 1200 ttt 1203 <210> 31 <211> 1095 <212> DNA <213> Artificial Sequence <400> 31 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccaatga gcagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 32 <211> 1092 <212> DNA <213> Artificial Sequence <400> 32 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca acaagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagtcaa 840 gttggaaaat ccaaatcccc agctcatgaa ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccagtga gcatcaatta gtgacagact tgcaatttta tggaaagctg 1080 tgggaaagct ag 1092 <210> 33 <211> 1080 <212> DNA <213> Artificial Sequence <400> 33 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcacgatg accaatatta ttttcaacta cagcaacaag ttcccctgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggctcgtag agctgcgttt gaacctctta caaaggaatc aaggaatcaa 780 gcaagagcca gggctagaga gagaacaaaa acaaagaaaa tgagccaagt tggaaaatcc 840 aaatccccag ctcatgattt gaacccttca ggatctcgga ggccggctaa tagatcttgt 900 gaagaacctg caacacatga acaacacacc ttccatcatg ttgatgacag taattttgtg 960 gttaatggaa attggaatcc atttacaatc ttcagctctc atgaacaata tgctggaatt 1020 tccaatgagc atcaattagt tacagacttg caattttatg gaaagctgtg ggaaagctag 1080 <210> 34 <211> 1092 <212> DNA <213> Artificial Sequence <400> 34 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gatactgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcacctc tcatgaacaa 1020 tatgctggaa tttccaatga gcatcaatta gttacagact tgcaatttta tggaaagctg 1080 tgggaaagct ag 1092 <210> 35 <211> 1095 <212> DNA <213> Artificial Sequence <400> 35 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga tagctgcact gagactgtta ctaaaccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgagcatcaa ttagttacag acttgcaatt ttatggaaag 1080 ctgtgggaaa gctag 1095 <210> 36 <211> 1092 <212> DNA <213> Artificial Sequence <400> 36 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaaa ttcccttgat agatgacttg 180 agtcctcaca tcttagctga gagctgcacc gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 ctcgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcagat tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggtaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagctag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatcggctaa taaaacttgt 900 gaagaacctg gaactcatga acaacacacc ttccatcatg agaagaacag cgtcgatgaa 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagcta tcatgaacaa 1020 tatgctggaa tttccaacga gcatcaatta gttacagact tgcaattttg tggaaagctg 1080 tgggaaagct ag 1092 <210> 37 <211> 1101 <212> DNA <213> Artificial Sequence <400> 37 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agtagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca ataccaccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagctag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatctcggag gccagctaat 900 agaacttgtg aagaacccgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaattttgt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag catcaattag ttacagactt gcaattttat 1080 ggaaagctgt gggaaagcta g 1101 <210> 38 <211> 1089 <212> DNA <213> Artificial Sequence <400> 38 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacccg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca agagatcttc caataaggat 360 cgacacagca agatcaacac ggctcgtggt ccaagagatc gaaggatgag actttcactt 420 gatgctgctc gcaagttttt ccgtttgcag gacttattgg gatttgataa ggccagcaaa 480 actgtagaat ggttgcttac tcaatcagat tccgcaattg aagagctcgt cgccgttaaa 540 ggcaatgatg ctcaggttcc tcagcaaact agctgcaata cccccactac tactactgga 600 attggtgcaa tttgtgcatc taattctatt tctgagtcat gtgaagttat atcaggaact 660 gatgaaactt cctctaatga caaaaacaag gaaactactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaagtt 840 ggaaaatcca aatccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatgt tgatgacagt 960 aattttgtgg ttaatggaaa ttggaatcca tttacaatct tcagctctca tgaacaatat 1020 gctggaattt ccaatgagca tcaattagtt acagacctgc aattttatgg aaagctgtgg 1080 gaaagctag 1089 <210> 39 <211> 1089 <212> DNA <213> Artificial Sequence <400> 39 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggcttct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaagtt 840 ggaaaatcca aatccccagt tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatgt tgatgacact 960 aattttgtgg ttaatggaaa ttggaatcca tttacaatct tcagctctca tgaacaatat 1020 gctggaattt ccaatgagca tcaattagtt acagacttgc aattttatgg aaagctgtgg 1080 gaaagctag 1089 <210> 40 <211> 364 <212> PRT <213> Artificial Sequence <400> 40 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro Pro His 50 55 60 Val Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys 65 70 75 80 Asn His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly 85 90 95 Asp Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Thr Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Pro Arg Arg Ala Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Val His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Tyr Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 41 <211> 363 <212> PRT <213> Artificial Sequence <400> 41 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Thr Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys Glu 225 230 235 240 Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro 245 250 255 Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg 260 265 270 Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Ala 275 280 285 His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys 290 295 300 Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp Asp 305 310 315 320 Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Thr 325 330 335 Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val Thr 340 345 350 Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 42 <211> 364 <212> PRT <213> Artificial Sequence <400> 42 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Ile Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Pro Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Ser Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Ala His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Ser Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 43 <211> 364 <212> PRT <213> Artificial Sequence <400> 43 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Pro Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Ser Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Ala His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Ser Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 44 <211> 364 <212> PRT <213> Artificial Sequence <400> 44 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Gln Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Gly 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Ile Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Val Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ala Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Gly Ser Ala Asn Lys Thr Cys Glu Glu Pro 290 295 300 Gly Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser Val Asp 305 310 315 320 Glu Ser Asn Phe Val Val Asn Gly Tyr Trp Asn Pro Phe Thr Ile Phe 325 330 335 Ser Tyr His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Cys Gly Lys Leu Trp Glu Ser 355 360 <210> 45 <211> 363 <212> PRT <213> Artificial Sequence <400> 45 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Leu Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Thr Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Asn Asp Leu Asn Pro 275 280 285 Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu Glu Glu Pro Gly 290 295 300 Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser Val Asn Asp 305 310 315 320 Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser 325 330 335 Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val Thr 340 345 350 Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 46 <211> 366 <212> PRT <213> Artificial Sequence <400> 46 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Leu Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Gln Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Ser Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Gln Ala Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser 305 310 315 320 Val Asp Asp Ser Asn Phe Leu Val Asn Gly Asn Trp Asn Pro Phe Thr 325 330 335 Ile Phe Ser Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln 340 345 350 Leu Val Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 365 <210> 47 <211> 364 <212> PRT <213> Artificial Sequence [[ID=3,7]]<400> 47 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Thr Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Ala His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 48 <211> 364 <212> PRT <213> Artificial Sequence <400> 48 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Ala His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 49 <211> 366 <212> PRT <213> Artificial Sequence <400> 49 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Leu Leu Ile Asp Asp Leu Ser Pro Arg Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Arg Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Gln Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Phe Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Thr Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ala Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr Asn Glu Gln His Thr Phe His His Asp Lys Asn Ser 305 310 315 320 Val Asp Asp Ser Asn Phe Leu Val Asn Gly Asn Trp Asn Pro Phe Thr 325 330 335 Ile Phe Ser Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln 340 345 350 Leu Val Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 365 <210> 50 <211> 364 <212> PRT <213> Artificial Sequence <400> 50 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Ala His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Ile 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 51 <211> 363 <212> PRT <213> Artificial Sequence <400> 51 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys Glu 225 230 235 240 Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro 245 250 255 Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg 260 265 270 Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Ala 275 280 285 His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys 290 295 300 Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp Asp 305 310 315 320 Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser 325 330 335 Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val Thr 340 345 350 Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 52 <211> 364 <212> PRT <213> Artificial Sequence <400> 52 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Ala Pro Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Ile Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Ala Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Val Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ala Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Gly Ser Ala Asn Lys Thr Cys Glu Glu Pro 290 295 300 Gly Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser Val Asp 305 310 315 320 Glu Ser Asn Phe Val Val Asn Gly Tyr Trp Asn Pro Phe Thr Ile Phe 325 330 335 Ser Tyr His Glu Gln Tyr Ala Gly Val Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Cys Gly Lys Leu Trp Glu Ser 355 360 <210> 53 <211> 366 <212> PRT <213> Artificial Sequence <400> 53 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Gln Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ser Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser 305 310 315 320 Val Asp Asp Ser Asn Phe Leu Val Asn Gly Asn Trp Asn Pro Phe Thr 325 330 335 Ile Phe Ser Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln 340 345 350 Leu Val Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 365 <210> 54 <211> 364 <212> PRT <213> Artificial Sequence <400> 54 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser 100 105 110 Lys Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn 115 120 125 Thr Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala 130 135 140 Ala Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala 145 150 155 160 Ser Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu 165 170 175 Glu Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr 180 185 190 Ser Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala 195 200 205 Ser Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu 210 215 220 Thr Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys 225 230 235 240 Glu Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu 245 250 255 Pro Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu 260 265 270 Arg Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro 275 280 285 Ala His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr 290 295 300 Cys Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp 305 310 315 320 Asp Ser Ser Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe 325 330 335 Thr Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 55 <211> 363 <212> PRT <213> Artificial Sequence <400> 55 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp His Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys [[ID= Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ala Pro Ala His 275 280 285 Asp Leu Asn Leu Ser Gly Ser Ala Ser Lys Thr Cys Glu Glu Pro Gly 290 295 300 Thr His Glu Gln His Asn Phe His His Glu Lys Ile Ser Val Asp Glu 305 310 315 320 Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser 325 330 335 Ser His Glu Gln Tyr Ala Gly Met Ser Asn Glu His Gln Leu Val Thr 340 345 350 Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 56 <211> 366 <212> PRT <213> Artificial Sequence <400> 56 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Leu Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Gln Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ala Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser 305 310 315 320 Val Asp Asp Ser Asn Phe Leu Val Asn Gly Asn Trp Asn Pro Phe Thr 325 330 335 Ile Phe Ser Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln 340 345 350 Leu Val Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 365 <210> 57 <211> 362 <212> PRT <213> Artificial Sequence <400> 57 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Gln Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp Asp Ser 305 310 315 320 Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser Ser 325 330 335 His Glu Gln Tyr Ala Gly Ile Ser Ser Glu His Gln Leu Val Thr Asp 340 345 350 Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 58 <211> 401 <212> PRT <213> 人工序列(Artificial Sequence) <400> 58 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Phe Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Asn Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Glu 85 90 95 Asp Ala Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Pro Val Asn Thr Gly Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ser Ser Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Thr Asn Arg Thr Cys 290 295 300 Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Glu Lys Asn 305 310 315 320 Ser Val Asp Asp Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe 325 330 335 Thr Ile Phe Ser Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu Thr 340 345 350 Cys Asn Phe Met Glu Ser Cys Gly Lys Ala Arg Ala Arg Lys Phe Glu 355 360 365 Ala Asp Lys Val Pro Ser Ser Phe Cys Ala Tyr Ser Ala Glu Gln Lys 370 375 380 Asn Val Ser Gly Leu Tyr Leu Leu Val Asn Val Thr Tyr Ile Arg Thr 385 390 395 400 Phe <210> 59 <211> 364 <212> PRT <213> Artificial Sequence <400> 59 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys Glu 225 230 235 240 Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro 245 250 255 Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg 260 265 270 Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Ala 275 280 285 His Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys 290 295 300 Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp Asp 305 310 315 320 Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser 325 330 335 Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu Gln His Gln Leu Val 340 345 350 Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 60 <211> 363 <212> PRT <213> Artificial Sequence <400> 60 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys Glu 225 230 235 240 Lys Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro 245 250 255 Leu Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg 260 265 270 Thr Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Ala 275 280 285 His Glu Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys 290 295 300 Glu Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp Asp 305 310 315 320 Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser 325 330 335 Ser His Glu Gln Tyr Ala Gly Ile Ser Ser Glu His Gln Leu Val Thr 340 345 350 Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 61 <211> 359 <212> PRT <213> Artificial Sequence <400> 61 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Pro Ala Arg Arg Ala Ala Phe Glu Pro Leu Thr Lys Glu 245 250 255 Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr Lys Thr Lys 260 265 270 Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Ala His Asp Leu Asn 275 280 285 Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Ser Cys Glu Glu Pro Ala 290 295 300 Thr His Glu Gln His Thr Phe His His Val Asp Asp Ser Asn Phe Val 305 310 315 320 Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser Ser His Glu Gln 325 330 335 Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val Thr Asp Leu Gln Phe 340 345 350 Tyr Gly Lys Leu Trp Glu Ser 355 <210> 62 <211> 363 <212> PRT <213> Artificial Sequence <400> 62 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Ile Pro Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Glu Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Ile Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Val Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ala Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Ala Asn Lys Thr Cys Glu Glu Pro Gly 290 295 300 Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser Val Asp Glu 305 310 315 320 Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser 325 330 335 Tyr His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val Thr 340 345 350 Asp Leu Gln Phe Cys Gly Lys Leu Trp Glu Ser 355 360 <210> 63 <211> 366 <212> PRT <213> Artificial Sequence <400> 63 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Leu Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Gln Gln Gln Gln Val Leu Leu Ile Asp Asp Leu Ser Pro His Ile 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Gln Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Thr Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Ala Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Ile Gly Lys Ser Lys Ala Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr His Glu Gln His Thr Phe His His Glu Lys Asn Ser 305 310 315 320 Val Asp Asp Ser Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr 325 330 335 Ile Phe Ser Ser His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln 340 345 350 Leu Val Thr Asp Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 365 <210> 64 <211> 362 <212> PRT <213> Artificial Sequence <400> 64 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Pro Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr Ala 115 120 125 Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala Arg 130 135 140 Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser Lys 145 150 155 160 Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu Leu 165 170 175 Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser Cys 180 185 190 Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser Asn 195 200 205 Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr Ser 210 215 220 Ser Asn Asp Lys Asn Lys Glu Thr Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Ala His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp Asp Ser 305 310 315 320 Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser Ser 325 330 335 His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val Thr Asp 340 345 350 Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 65 <211> 362 <212> PRT <213> Artificial Sequence <400> 65 Met Tyr Pro Pro Ser Asn Asn Asn Cys Asn Tyr Ser Pro Ile Leu Ser 1 5 10 15 Ser Phe Ile Cys Gln Asn Ile Pro Ser Ser Pro Cys Met Gln Tyr Glu 20 25 30 His Glu Leu Tyr Phe Gln Asn Phe Asn His Asp Asp Gln Tyr Tyr Phe 35 40 45 Gln Leu Gln Gln Gln Val Pro Leu Ile Asp Asp Leu Ser Pro His Val 50 55 60 Leu Ala Asp Ser Cys Thr Glu Thr Val Thr Lys Pro Ser Asn Cys Asn 65 70 75 80 His Val Leu Glu Gly Met Glu Glu Gly Arg Gly Gly Asn Lys Gly Asp 85 90 95 Asp Val Met Ser Ser Arg Ile Ser Ile Ile Ser Gly Arg Ile Ser Lys 100 105 110 Asn Asn Lys Arg Ser Ser Asn Lys Asp Arg His Ser Lys Ile Asn Thr 115 120 125 Ala Arg Gly Pro Arg Asp Arg Arg Met Arg Leu Ser Leu Asp Ala Ala 130 135 140 Arg Lys Phe Phe Arg Leu Gln Asp Leu Leu Gly Phe Asp Lys Ala Ser 145 150 155 160 Lys Thr Val Glu Trp Leu Leu Thr Gln Ser Asp Ser Ala Ile Glu Glu 165 170 175 Leu Val Ala Val Lys Gly Asn Asp Ala Gln Val Pro Gln Gln Thr Ser 180 185 190 Cys Asn Thr Pro Thr Thr Thr Thr Gly Ile Gly Ala Ile Cys Ala Ser 195 200 205 Asn Ser Ile Ser Glu Ser Cys Glu Val Ile Ser Gly Thr Asp Glu Thr 210 215 220 Ser Ser Asn Asp Lys Asn Lys Glu Thr Ala Lys Asp Glu Lys Glu Lys 225 230 235 240 Lys Lys Lys Pro Val Asn Thr Ala Arg Arg Ala Ala Phe Glu Pro Leu 245 250 255 Thr Lys Glu Ser Arg Asn Gln Ala Arg Ala Arg Ala Arg Glu Arg Thr 260 265 270 Lys Thr Lys Lys Met Ser Gln Val Gly Lys Ser Lys Ser Pro Val His 275 280 285 Asp Leu Asn Pro Ser Gly Ser Arg Arg Pro Ala Asn Arg Thr Cys Glu 290 295 300 Glu Pro Gly Thr His Glu Gln His Thr Phe His His Val Asp Asp Thr 305 310 315 320 Asn Phe Val Val Asn Gly Asn Trp Asn Pro Phe Thr Ile Phe Ser Ser 325 330 335 His Glu Gln Tyr Ala Gly Ile Ser Asn Glu His Gln Leu Val Thr Asp 340 345 350 Leu Gln Phe Tyr Gly Lys Leu Trp Glu Ser 355 360 <210> 66 <211> 1176 <212> DNA <213> Artificial Sequence <400> 66 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcctc acgtcttagc tgatagctgc actgagactg ttactaagcc ttcaaattgc 240 aatcacgtac tagaaggaat ggaagaaggc cgaggcggaa acaaaggaga tgatgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg ttgaatggtt gcttactcaa tcggataccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacacct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagttcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccatata caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaaatccag taaatttcta 1080 tttatatata ttcttatcag cttctgaatt cttatttctc tgcagcatca attagttaca 1140 gacttgcaat tttatggaaa gctgtgggaa agctag 1176 <210> 67 <211> 1183 <212> DNA <213> Artificial Sequence <400> 67 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 Met-Tyr-Pro-Pro-Ser-Ala-Thr-Asn-Cys-Asn-Thr-Ser-Pro-Asn-Phe-Val-Phe-Phe-His-Met 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 Gln-Asn-Tyr-Ser-Ser-Ser-Ser-Val-Met-Gln-Tyr-Glu-Thr-Asn-Tyr-Thr-Phe-Lys-Thr-Phe 1 ... aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 18... Asn-His-Asp-Asp-Gln-Ile-Tyr-Phe-Gln-Leu-Ser-Gln-Lys-Phe-Pro-Leu-Asp-Asp-Asp-Leu 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 Ser-Pro-Thr-Ser-Leu-Ala-Asp-Ser-Ala-His-Glu-Thr-Val-Thr-Lys-Pro-Phe-Lys-Cys-Asn 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 His-Val-Leu-Glu-Gly-Met-Glu-Lys-Ala-Glu-Gly-Glu-Gln-Lys-Glu-Asp-Val-Met-Ser 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 Ser-Gln-Ile-Ser-Ile-Ile-Ser-Trp-Thr-Gly-Ser-Glu-Lys-Thr-Ile-Arg-Ile-Phe-Pro-Ile-Lys 360 gatcgacaca gtaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 Asp-Arg-Thr-Val-Lys-Ile-Gln-Thr-Gly-Leu-Val-Pro-Glu-Ile-Glu-Asp-Ala-Asp-Phe-Ser 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 Leu-Asp-Ala-Ala-Ser-Lys-Phe-Phe-Pro-Phe-Ala-Asp-Tyr-Trp-Asp-Phe-Asp-Lys-Ala-Ser 480 aaaactgtag aatggttgct tactcaatcg gataccgcaa ttgaagagct cgtcgccgtt 540 Lys-Thr-Val-Glu-Trp-Leu-Leu-Thr-Ser-Asp-Thr-Ala-Asn-Glu-Glu-Leu-Val-Ala-Val 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 Lys-Ala-Met-Asp-Ala-Arg-Val-Pro-Ser-Gln-Thr-Ser-Ala-Tyr-Thr-Pro-Thr-Tyr-Tyr-Tyr 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 Gly-Ile-Gly-Ala-Phe-Val-His-Leu-Ile-Ser-Tyr-Phe-Ser-Ser-Met-Val-Lys-Tyr-Ile-Arg 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 Thr-Asp-Glu-Lys-Phe-Pro-Leu-Met-Thr-Lys-Asn-Lys-Glu-Thr-Thr-Ala-Lys-Asp-Glu-Lys-Glu 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcacctc tcatgaacaa 1020 tatgctggaa tttccaatga ggtgaggcct tcaataatta aatccagtag atttctattt 1080 atatatatat atattcttat cagtttctaa aaaaatcctt atttctctgc agcatcaatt 1140 agttacagac ttgcaatttt atggaaagct gtgggaaagc tag 1183 <210> 68 <211> 1199 <212> DNA <213> Artificial Sequence <400> 68 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ttctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaattaaat ccagtagatt 1080 tctatttata tatatatata tatatatatt cttatcagct tctaaaaaaa atccttattt 1140 ctctgcagca tcaattagtt acagacttgc aattttatgg aaagctgtgg gaaagctag 1199 <210> 69 <211> 1190 <212> DNA <213> Artificial Sequence <400> 69 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctattgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaatcaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaatc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaattaaat ccagtagatt 1080 tctattatat atatatatat tcttatcagc ttctaaaaaa attccttatt tctctgcagc 1140 atcaattagt tacagacttg caattttatg gaaagctgtg ggaaagctag 1190 <210> 70 <211> 1183 <212> DNA <213> Artificial Sequence <400> 70 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaatcaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaattaaat ccagtagata 1080 tatatatata tattcttatc agcttctaaa aaaattcctt atttctctgc agcatcaatt 1140 agttacagac ttgcaatttt atggaaagct gtgggaaagc tag 1183 <210> 71 <211> 1199 <212> DNA <213> Artificial Sequence <400> 71 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tgttgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagacctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ttctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaattaaat ccagtagatt 1080 tctatttata tatatatata tatatatatt cttatcagct tctaaaaaaa atccttattt 1140 ctctgcagca tcaattagtt acagacttgc aattttatgg aaagctgtgg gaaagctag 1199 <210> 72 <211> 1217 <212> DNA <213> Artificial Sequence <400> 72 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 aatcatgacg accaatatta ttttcaacaa cagcaacaag ttcccttaat agatgacttg 180 agtcctcaca tcttagctga cagctgcacc gagactgtta ctaagccttc aaattgcaat 240 cacgtacaag aaggaatgga agaaggccga ggcggaaaca aaggaggtga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcagat tcctcagcaa actagctgca atactcccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggtaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gaggatcggc taataaaact 900 tgtgaagaac ctggaactca tgaacaacac accttccatc atgagaagaa cagtgtcgat 960 gaaagtaatt ttgtggttaa tggatattgg aatccattta caatcttcag ctatcatgag 1020 caatatgctg gaatttccaa tgaggtaagg gtttcagaat ttgtttatta gggcttcaat 1080 aattaaatcc agattatata aatagatgat ttccatttat atattcttat cagtttctga 1140 gtttttcctt atttctctgc acgcagcatc aattagttac agacttgcaa ttttgtggaa 1200 agctgtggga aagctag 1217 <210> 73 <211> 1215 <212> DNA <213> Artificial Sequence <400> 73 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcaca gagactgtta ctaagccttc aaattgcaat 240 cacgtactcg aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcaccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca atgatttgaa cccttcagga tctcggaggc cggctaatag aacttgtgaa 900 gaagaacctg gaacacatga acaacacacc ttccatcatg agaagaacag tgttaatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccaatga ggtgagggtt tcagactttg tttattaggg cttcaataat 1080 taaatccagt agatttctat ttatttatat atatatatat cagcttctga ttttttttga 1140 aaaaaaattc ttatttctct gcagcatcaa ttagttacag acttgcaatt ttatggaaag 1200 ctgtgggaaa gctag 1215 <210> 74 <211> 1235 <212> DNA <213> Artificial Sequence <400> 74 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttcttttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtg 540 aaaggcaatg atgctcaggt ttctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatccc aagccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag gtgagggttt cagactttgt ttattagggc 1080 ttcaataatt aaatccagta gatttctatt ttttatatat atatatatat atattcttat 1140 cagcttctga ttttttttga aaaaaaattc ttatttctct gcagcatcaa ttagttacag 1200 atttgcaatt ttatggaaag ctgtgggaaa gctag 1235 <210> 75 <211> 1198 <212> DNA <213> Artificial Sequence <400> 75 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gaaactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga ggaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgcgactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggataccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgaaaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaaatccag tagatttcta 1080 tttatttata tatatattct tatcagcttc tgattttttt tgaaaaaaaa ttcttattta 1140 tctgcagcat caattagtta cagacttgca attttatgga aagctgtggg aaagctag 1198 <210> 76 <211> 1194 <212> DNA <213> Artificial Sequence <400> 76 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta tttccaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga tagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcaaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gtttcaataa ttaaatccag tagatttcta 1080 tttatatgta tattcttatc agcttctgat tttttttgaa aaaaaattct tatttctctg 1140 cagcatcaat tagttacaga cttgcaattt tatggaaagc tgtgggaaag ctag 1194 <210> 77 <211> 1210 <212> DNA <213> Artificial Sequence <400> 77 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcgca tcttagctga cagctgcact gagactgtta ctaagcgttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtatttttag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caagacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctacgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacaaatgaa caacacacct tccatcatga caagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag gtgagggttt cagactttgt ttattagggc 1080 ttcaataatt aaatccagta gatttctata tatatcagct tctgattttt tttgaaaaaa 1140 aattcttatt tctctgcagc atcaattagt tacagacttg caattttatg gaaagctgtg 1200 ggaaagctag 1210 <210> 78 <211> 1196 <212> DNA <213> Artificial Sequence <400> 78 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc cgtcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcgtgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacgaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa tttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaattaaat ccagtagatt 1080 tctattttta tatatatata tatatatata tacttatcag cttctgaatt cttatttctc 1140 tgcagcatca attagttaca gacttgcaat tttatggaaa gctgtgggaa agctag 1196 <210> 79 <211> 1179 <212> DNA <213> Artificial Sequence <400> 79 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 ATGTATCCTC CAAGCAACAA TAACTGCAAC TACAGCCCAATTTTGTCTTC TTTCATATGC 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 CAAAAATATTC CATCTTCTCC TTGTATGCAATACGAACACG AACTATACTT TCAAAACTTC 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacctg 180 AATCATGATG ACCAATATTATTTTCAACTACAGCAACAAG TTCCCTTGAT AGATGACCTG 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 AGTCCTCACG TCTTAGCTGA CAGCTGCACT GAGACTGTTA CTAAGCCTTC AAATTGC AAT 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 CACGTACTAG AAGGAATGGA AGAAGGCCGA GGCGGAAACAAAGGAGATGA TGTTATGAGT 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 AGCAG AATTA GTATTATTAG TGGA CGGAT CTCGAAAACA ATA AGA GATC TTCC ATA AG 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 GATCGACACAGCAAGATCAA CACGGCTCGT GGTC CAAGA GATC GAAGGAT GCGACTTTC A 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttac tgggatttga taaggccagc 480 CTTGATGCTG CTCGCAAGTT TTTCCGTTTG CAGGACTTAC TGGGA TTTGA TA AGGCCAGC 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 AAAACTGTAG AATGGTTGCT TACTCAATCAGATTCCGCAA TTGAAGAGCT CGT CGCCGTT 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 AAAGGCAATG ATGCT CAGGT TCCTCAGCAA ACTAGCTGCA ATACCCCCAC TACTACTACT 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 GGAA TTGG TG CAATTTGTG C ATCTAATTCT ATTTCTGAGT CATGTGAAGT TATATCAGGA 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 ACTGATGAAA CTTCC TCTAA TGACAAAAAC AAGGA AACTACTGCT AAAGA TGAGA AGGAG 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aacagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccaatga ggtgagggct tcaattatta aatccagtag attcctattt 1080 atatatatat tcttatcagc ttctaaaaaa attcttattt ctctgcagca tcaattagtt 1140 acagacttgc aattttatgg aaagctgtgg gaaagctag 1179 <210> 80 <211> 1197 <212> DNA <213> Artificial Sequence <400> 80 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc cgtcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgct 540 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgct 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaattaaat ccagtagatt 1080 tctattttta tatatatata tatatattct tatcagcttc taaaaaaaat ccttatttct 1140 ctgcagcatc aattagttac agacttgcaa ttttatggaa agctgtggga aagctag 1197 <210> 81 <211> 1217 <212> DNA <213> Artificial Sequence <400> 81 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ctcccttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcacc gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcagat tcctcagcaa actagctgca atacccccac tgctactact 600 ggaataggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggtaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gaggatcggc taataaaact 900 tgtgaagaac ctggaactca tgaacaacac accttccatc atgagaagaa cagtgtcgat 960 gaaagtaatt ttgtggttaa tggatattgg aatccattta caatcttcag ttatcatgag 1020 caatatgctg gagtttccaa tgaggtaagg gtttcagaat ttgtttatta gggcttcaat 1080 aattaaatcc agattatata aatagatgat ttccatttat atattcttat cagtttctga 1140 gtttttcctt atttctctgc acgcagcatc aattagttac agacttgcaa ttttgtggaa 1200 agctgtggga aagctag 1217 <210> 82 <211> 1224 <212> DNA <213> Artificial Sequence <400> 82 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttcccttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cactgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaaatt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaagggaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcatctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagtcaaatt 840 ggaaaatcca aatccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag gtgagggttt cagactttgt ttattagggc 1080 ttcaataatt aaatccagta gatttctatt tatatatata tattcttatc agcttctgat 1140 tttttttgaa aaaaaattct tatttttctg cagcatcaat tagttacaga cttgcaattt 1200 tatggaaagc tgtgggaaag ctag 1224 <210> 83 <211> 1189 <212> DNA <213> Artificial Sequence <400> 83 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc gcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtagtt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaattaaat ccagtagatt 1080 tctatttata tatatatatt cttatcagct tctaaaaaaa atccttattt ctctgcagca 1140 tcaattagtt acagacttgc aattttatgg aaagctgtgg gaaagctag 1189 <210> 84 <211> 1214 <212> DNA <213> Artificial Sequence <400> 84 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacatg aactatactt tcaaaacttt 120 aatcatgatg accattatta ttttcaacaa cagcaacaag ttcccttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcacc gagactgtta ctaagccttc aaactgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata acaagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 ctcgatgccg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaagat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacctttcag gatcggctag taaaacttgt 900 gaagaacctg gaactcatga acaacacaac ttccatcatg agaagatcag tgtcgatgaa 960 agtaattttg ttgttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tgtccaatga ggtgagggtt tcagactttg tttattaggg cttcaataat 1080 taaatccagt agatttctat ttatatataa tattcttatc agcttctgat tttttttgaa 1140 aaaaaattct tatttctctg cagcatcaat tagttacaga cttgcagttt tatggaaagc 1200 tgtgggaaag ctag 1214 <210> 85 <211> 1230 <212> DNA <213> Artificial Sequence <400> 85 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgacgctg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgta atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaatttttt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag gtgagggttt cagactttgt ttattagggc 1080 ttcaataatt aaatccagta gatttctatt tatatatata tatatatatt cttatcagct 1140 tctgattttt tttgaaattt ttttcttatt tctctgcagc atcaattagt tacagacttg 1200 caattttatg gaaagctgtg ggaaagctag 1230 <210> 86 <211> 1190 <212> DNA <213> Artificial Sequence <400> 86 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacctg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aagaagaagc cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaagtt 840 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaagtt 840 ggaaaatcca aatccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 ggaaaatcca aatccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa cacacacct tccatcatgt tgatgacagt 960 aattttgtgg ttaatggaaa ttggaatcca tttacaatct tcagctca ttsacaat 1020 gctggaattt ccagtgaggt gagggcttca ataattaaat ccagtagatt tctatttata 1080 tatatatatt cttatcagct tctgattt ttgaaaaa atttcttt tctctgcagc 1140 atcattagt tacagacttg cattttg gaagctgtg ggaagctag 1190 <210> 87 <211> 1316 <212> DNA <213>人工序列(Artificial Sequence) <400> 87 atgtatccctc caagcaacaa taactgcaac tacagcccaa tttgtcttc tttaatattc 60 caaaatattc catcttctcc tgtatgca tatgaacacg acatactt tcaaacttt 120 aatcatgatg accaatatta tttcacta cagcacaag ttccctgat agatgacttg 180 aatcctcaca tcttagctga tagctgcaca gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaagccga ggcggaaca aaggagaga tgctatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgccg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac aggtcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aatcctcagc tcatgatttg aacccttcag gatctcggag gccggctact 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgagaagaac 960 agtgttgatg acagtaattt tgtggttaat ggaaattgga atccatttac aatcttcagc 1020 tctcatgaac aatatgctgg aatttccaat gaggtgaggg cttcaataat taaatccagt 1080 agatttctat ttatatatat tcttatcagc ttctgatttt ttttgaaaaa aaattcttat 1140 ttctctgcag catcaattag ttacagactt gcaattttat ggaaagctgt gggaaagcta 1200 gggcaaggaa attcgaagcg gacaaagttc cttcttcatt ttgtgcttac tcggccgagc 1260 agaagaacgt ttccggcctg tatctgttgg taaatgtaac atacattcgt actttt 1316 <210> 88 <211> 1179 <212> DNA <213> Artificial Sequence <400> 88 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccaatga ggtgagggct tcaataatta aatccagtag atttctattt 1080 atatatatat tcttatcagc ttctaaaaaa attcttattt ctcagcagca tcaattagtt 1140 acagacttgc aattttatgg aaagctgtgg gaaagctag 1179 <210> 89 <211> 1205 <212> DNA <213> Artificial Sequence <400> 89 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca acaagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gcgactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagtcaa 840 gttggaaaat ccaaatcccc agctcatgaa ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagctc tcatgaacaa 1020 tatgctggaa tttccagtga ggtgagggca tcaataatta aatccagtag atttctactt 1080 atatatatat atatatatat tcttatcagc ttctgatttt ttttgaaaaa aaaaaaaatc 1140 ttatttctct gcagcatcaa ttagtgacag acttgcaatt ttatggaaag ctgtgggaaa 1200 gctag 1205 <210> 90 <211> 1175 <212> DNA <213> Artificial Sequence <400> 90 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcacgatg accaatatta ttttcaacta cagcaacaag ttcccctgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggctcgtag agctgcgttt gaacctctta caaaggaatc aaggaatcaa 780 gcaagagcca gggctagaga gagaacaaaa acaaagaaaa tgagccaagt tggaaaatcc 840 aaatccccag ctcatgattt gaacccttca ggatctcgga ggccggctaa tagatcttgt 900 gaagaacctg caacacatga acaacacacc ttccatcatg ttgatgacag taattttgtg 960 gttaatggaa attggaatcc atttacaatc ttcagctctc atgaacaata tgctggaatt 1020 tccaatgagg tgagggcttc aataattaaa tccagtagat ttttctatat atatatatat 1080 attcttatga ttttttttga aaaaaaattc ttatttctct gcagcatcaa ttagttacag 1140 acttgcaatt ttatggaaag ctgtgggaaa gctag 1175 <210> 91 <211> 1183 <212> DNA <213> Artificial Sequence <400> 91 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gatactgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaacta ctgctaaaga tgagaaggag 720 aaaaagaaga agccggttaa cacagctcgt agagctgcgt ttgaacctct tacaaaggaa 780 tcaaggaatc aagcaagagc cagggctaga gagagaacaa aaacaaagaa aatgagccaa 840 gttggaaaat ccaaatcccc agctcatgat ttgaaccctt caggatctcg gaggccggct 900 aatagaactt gtgaagaacc tggaacacat gaacaacaca ccttccatca tgttgatgac 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcacctc tcatgaacaa 1020 tatgctggaa tttccaatga ggtgagggct tcaataatta taattaaatc cagtagattt 1080 ctatttttat atatatattc tcatcagctt ctgaattctt atttctctgc agcatcaatt 1140 agttacagac ttgcaatttt atggaaagct gtgggaaagc tag 1183 <210> 92 <211> 1180 <212> DNA <213> Artificial Sequence <400> 92 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga tagctgcact gagactgtta ctaaaccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttgttatg 300 agtagcagaa ttagtattat tagtggacgg atctcgaaaa acaataagag atcttccaat 360 aaggatcgac acagcaagat caacacggct cgtggtccaa gagatcgaag gatgagactt 420 tcacttgatg ctgctcgcaa gtttttccgt ttgcaggact tattgggatt tgataaggcc 480 agcaaaactg tagaatggtt gcttactcaa tcggattccg caattgaaga gctcgtcgcc 540 gttaaaggca atgatgctca ggttcctcag caaactagct gcaatacccc cactactact 600 actggaattg gtgcaatttg tgcatctaat tctatttctg agtcatgtga agttatatca 660 ggaactgatg aaacttcctc taatgacaaa aacaaggaaa ctactgctaa agatgagaag 720 gagaaaaaga agaagccggt taacacagct cgtagagctg cgtttgaacc tcttacaaag 780 gaatcaagga atcaagcaag agccagggct agagagagaa caaaaacaaa gaaaatgagc 840 caagttggaa aatccaaatc cccagctcat gatttgaacc cttcaggatc tcggaggccg 900 gctaatagaa cttgtgaaga acctggaaca catgaacaac acaccttcca tcatgttgat 960 gacagtaatt ttgtggttaa tggaaattgg aatccattta caatcttcac ctctcatgaa 1020 caatatgctg gaatttccaa tgaggtgagg gcttcaataa ttaaatccag tagatttata 1080 tatatatata ttcttatcag cttctaaaaa aatccttatt tctctgcagc atcaattagt 1140 tacagacttg caattttatg gaaagctgtg ggaaagctag 1180 <210> 93 <211> 1189 <212> DNA <213> Artificial Sequence <400> 93 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaaa ttcccttgat agatgacttg 180 agtcctcaca tcttagctga gagctgcacc gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaata ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 ctcgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggattcga taaggccagc 480 ctcgatgctg ctcgcaagtt tttccgtttg caggacttgt tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcagat tcctcagcaa actagctgca atacccccac tactactact 600 aaaggcaatg atgctcagat tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggtaactg ctaaagatga gaaggagaaa 720 actgatgaaa cttcctctaa tgacaaaaac aaggtaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagctag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 aggaatcaag caagagctag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatcggctaa taaaacttgt 900 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatcggctaa taaaacttgt 900 gaagaacctg gaactcatga acaacacacc ttccatcatg agaagaacag cgtcgatgaa 960 gaagaacctg gaactcatga acaacacacc ttccatcatg agaagaacag cgtcgatgaa 960 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagcta tcatgaacaa 1020 agtaattttg tggttaatgg aaattggaat ccatttacaa tcttcagcta tcatgaacaa 1020 tatgctggaa tttccaacga ggtaagggtt tcagaatttg tttattaggg cttcaataat 1080 tatgctggaa tttccaacga ggtaagggtt tcagaatttg tttattaggg cttcaataat 1080 taaatccaga ttataattct tatcagtttc tgagtttttc ctttttctct gcacgcagca 1140 tcaattagtt acagacttgc aattttgtgg aaagctgtgg gaaagctag 1189 <210> 94 <211> 1244 <212> DNA <213> Artificial Sequence <400> 94 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttaatatgc 60 caaaatattc catcttctcc ttgtatgcaa tatgaacacg aactatactt tcaaaacttt 120 aatcatgatg accaatatta ttttcaacaa cagcaacaag ttctcttgat agatgacttg 180 agtcctcaca tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccaa ggcggaaaca aaggagatga tgttatgagt 300 agtagaatta gtattattag tggacggatc tcgaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa caccgctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggattcga taaggccagc 480 aaaactgtag aatggttgct tactcaatcg gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca ataccaccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagg cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagctag ggctagagag agaacaaaaa caaagaaaat gagccaaatt 840 ggaaaatcca aagccccagc tcatgatttg aacccttcag gatctcggag gccagctaat 900 agaacttgtg aagaacccgg aacacatgaa caacacacct tccatcatga gaagaacagt 960 gttgatgaca gtaattttgt ggttaatgga aattggaatc catttacaat cttcagctct 1020 catgaacaat atgctggaat ttccaatgag gtgagggttt cagactttgt ttattagggc 1080 ttcaataact aaatccagta gatttctatt tatatatata tatatatata tatatatata 1140 tattcttatc agcttctgat tattttttta aaaaaattct tatttctctg cagcatcaat 1200 tagttacaga cttgcaattt tatggaaagc tgtgggaaag ctag 1244 <210> 95 <211> 1195 <212> DNA <213> Artificial Sequence <400> 95 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacccg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcgaaaaaca agagatcttc caataaggat 360 cgacacagca agatcaacac ggctcgtggt ccaagagatc gaaggatgag actttcactt 420 gatgctgctc gcaagttttt ccgtttgcag gacttattgg gatttgataa ggccagcaaa 480 actgtagaat ggttgcttac tcaatcagat tccgcaattg aagagctcgt cgccgttaaa 540 ggcaatgatg ctcaggttcc tcagcaaact agctgcaata cccccactac tactactgga 600 attggtgcaa tttgtgcatc taattctatt tctgagtcat gtgaagttat atcaggaact 660 gatgaaactt cctctaatga caaaaacaag gaaactactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaagtt 840 ggaaaatcca aatccccagc tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatgt tgatgacagt 960 aattttgtgg ttaatggaaa ttggaatcca tttacaatct tcagctctca tgaacaatat 1020 gctggaattt ccaatgaggt gagggctaca ataattaatc cagtagattt ctatttatat 1080 atatatatat atattcttat cagcttctga ttttttttga aaaaaaattc ttatttctct 1140 gcagcatcaa ttagttacag acctgcaatt ttatggaaag ctgtgggaaa gctag 1195 <210> 96 <211> 1187 <212> DNA <213> Artificial Sequence <400> 96 atgtatcctc caagcaacaa taactgcaac tacagcccaa ttttgtcttc tttcatatgc 60 caaaatattc catcttctcc ttgtatgcaa tacgaacacg aactatactt tcaaaacttc 120 aatcatgatg accaatatta ttttcaacta cagcaacaag ttcccttgat agatgacttg 180 agtcctcacg tcttagctga cagctgcact gagactgtta ctaagccttc aaattgcaat 240 cacgtactag aaggaatgga agaaggccga ggcggaaaca aaggagatga tgttatgagt 300 agcagaatta gtattattag tggacggatc tcaaaaaaca ataagagatc ttccaataag 360 gatcgacaca gcaagatcaa cacggctcgt ggtccaagag atcgaaggat gagactttca 420 cttgatgctg ctcgcaagtt tttccgtttg caggacttat tgggatttga taaggccagc 480 aaaactgtag aatggcttct tactcaatca gattccgcaa ttgaagagct cgtcgccgtt 540 aaaggcaatg atgctcaggt tcctcagcaa actagctgca atacccccac tactactact 600 ggaattggtg caatttgtgc atctaattct atttctgagt catgtgaagt tatatcagga 660 actgatgaaa cttcctctaa tgacaaaaac aaggaaactg ctaaagatga gaaggagaaa 720 aagaagaagc cggttaacac agctcgtaga gctgcgtttg aacctcttac aaaggaatca 780 aggaatcaag caagagccag ggctagagag agaacaaaaa caaagaaaat gagccaagtt 840 ggaaaatcca aatccccagt tcatgatttg aacccttcag gatctcggag gccggctaat 900 agaacttgtg aagaacctgg aacacatgaa caacacacct tccatcatgt tgatgacact 960 aattttgtgg ttaatggaaa ttggaatcca tttacaatct tcagctctca tgaacaatat 1020 gctggaattt ccaatgaggt gatggcttca ataattaaat ccagtagatt tctatttata 1080 tatatatata tatattctta tcagcttcta aaaaaaaaat tcttatttct ctgcagcatc 1140 aattagttac agacttgcaa ttttatggaa agctgtggga aagctag 1187 <210> 97 <211> 3000 <212> DNA <213> Artificial Sequence <400> 97 ttaatgttgt gaattctaat actccaaata ttaatgttgt gaattctaat actccacctg 60 ttttaaaaaa tggtctagtt tgacttgaaa cggaatttaa gaaaagaaaa aagactttct 120 aatcttgtga tgccaaatta aagttatgtc aaatatacca aaatgtcctt taatcttgtg 180 ctcttaaaca tgtcacgtga aaaattgaag ttaaagtgtt gccaaaaaaa gaaaggggtc 240 attatttttt aaacaaacta aaaaaaaaaa actaagtcat tccttttgaa acggagaaag 300 tatactatat ttatatattt ggttctcgca aacctgcaaa taagggcgga tgcacaatag 360 aagttacgag tttgattaaa tctactaatt ttatttaaac tttgtatata tgtgtagaga 420 agtcataaag ttcaaatact gaatttacta attttatcaa agttgtgatc tactgctaat 480 taaagttggg tgggcaggtg gggatgcccc gtattgggga atgtagtata ctgtacatct 540 aaaagcaatt ttggcaaaac catctctgtc actgatctct cacttcacaa tactaacata 600 tagagttggg gccaaagtag tcatgtagtt gatgggaaga gatagtacgg aggaatggag 660 aaaaaggtag gtgggtgagt tgggggaaga gatagggttc tctttttagt gaaagtgaca 720 tgctctaagg tcaaaagttg cattcttctc aaagggcaat tcagactttc atcactccct 780 agtgagggcg cagagctaga tatgcaaagg gtttatataa atttatgtga tacatttttt 840 ttagttaatc taaaaaaaga ataaaagttt ttttttttac caagatctat ttgaaatcac 900 acaaatattt gtgaatttag atcataaatt tcaaaaatct tttaataaaa ggttagcttc 960 tgttcttggc cttttagagg ttaggtacat gctccatccc ctcatttctt gttgttacta 1020 tttgccatgg ccggtaggaa tcaaggtcaa accccaatgc atcacaggtt agtatagtcc 1080 gaccgtgaca attttctatg ggggattgtg tagaatcaaa tatctattca taaattgaga 1140 cattgagacg aatattcttc tttacattat tgagacgaaa aaaatagtat ttaattttct 1200 taataaaaat cttagctccc cactatttgg tctaggtttc atattcaatg aattgctggg 1260 gtttatgtta ttactcaact gaaataaaaa gagaattgtc gttatccagg ttagacaaaa 1320 gcacgtgtag tttcaaacgc agtagccatt attctcctct cctttacagg tgagattcaa 1380 gggcagaaag gtaccatgca agctgttatt taaatttact tattgattat gatcgacgac 1440 tttgacagaa aaatgatgat gctttaattt tacgacctag tctttctttt taagaagaat 1500 aaaaaacata cctcaatttg gtataaacca atagtttcgt caatctaaaa aatattcttt 1560 tacttgactc actaaattta gatatatctt tgatctgtca cataacataa cataacaaat 1620 gatttcaaac ttttgtcgga acatatgact taataaaagg tggagaaagg ttgaaaactt 1680 tactaaattt aacaagatcc taggtgtgta tttgactcat gttgcaagat tgaagcgtat 1740 ttaagtttag ttagtcaagt aaagagatat ttttaaggtt gtcaatatat aattcagaga 1800 taaaactaat aattcacact gaatttaggg ggtgttttca atactcttct tttgtttcat 1860 ttcttgagtt taaaattaag ttgatatgga acaacaaata aattgtgatc ccaagtttta 1920 tatgagtaaa ataaaatcaa gcattgtata tctctctttt atttttctcc ctggtgtccg 1980 cattggagcc cgactatatt tgattcacac tataggcttc atttttttca tactcagggc 2040 ttaaatctga aatctgtggg taagggtaga atatcttata tctctttttt tttttttttt 2100 ttagattttc catccaacgt ttgttaccca cattgaagtt cagttaattc aaatttgcac 2160 cgcataggct aagcggttcc taccaatgat cttttcatac ctagggattc aaacgcaaaa 2220 catttattta agaaataaat agtctcatcc gctatatagt gtggtatatc tcattaaaaa 2280 gataccacat tatatctatt taaggggggt aggggggatg ggtctagcta gggttgtgga 2340 aatgaggtta gagagagggt ggtttttcag tgtgtgtgtc aggtgaaatc acgtgaaggg 2400 gcacgataac aagttgttca tatccattca cttccaagaa taccgctacg tacagtcact 2460 agctgctttc ttcctatccc catctttgtc aaatttcctt tccttttcca attacttttt 2520 ctttaataga catggacgca attcttcctt cctttcccct tcccctatat tcttccttta 2580 tctctctttc acaataatag caccatgcct gtagcttgat gcttagacgg gtgcacacgc 2640 actctcactc acacagctag aatatatata ttcatagtta gcagaagtac ttttcatata 2700 ccaaaaacca cacaaataca ttgtatcaag tgctgtcata ctcgagcaaa agaaagaaaa 2760 gaacaagata tagtagtact actgttttca tcaccaattt tggtcaatca tgatgattct 2820 gaacaaagat atagtactag ctaggtagaa aataaatcta gcaactttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagtagcaa aatcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 98 <211> 3000 <212> DNA <213> Artificial Sequence <400> 98 taagctgatt cggtgggaaa atcatgtttt atatcacaaa ttttttaggt tgccgatcca 60 gagaatttaa atattaatgt tgtgaattct aatactccac ctgttttaaa aaatggtcta 120 gtttgacttg aaacggagtt taagaaaaga aaaaagactt tctaatcttg tgattccaaa 180 ttaaagttat gtcaaatgta ccaaaatgtc ctttaatctt gtggtcttaa acatgtcacg 240 tgaaaaattg aagttaaagt gttgcaaaaa aaaaaggggt cattcttttt taaacaaact 300 aaaaaagaaa actaagtcat tccttttgaa acggaggatg tatactatat ttatatattt 360 ggttctcgca aacctgcaaa taagggcgga tgcacaacag aagttacgag tttgattaaa 420 tcttctaatt ttagtttaaa ctttgtatat atgcgtagag aagtcataaa gttcaaatac 480 tgaatttact aattttatca aagttgtgat ctactgctga ttaaagttgg gtgggcaggt 540 ggggatgccc ggtattgggg aatgtagtat actgtacatc taaaagcaat tttggcaaaa 600 ccatctctgt cactgatctc tcacttcaca atactaacat atagagttgg ggccaaagta 660 gtcatgtagt tgatgggaag agatagtacg gaggaatgga gaaaaaggta ggtgggtgag 720 ttgggggaag agatagggtt ctctttttag tgaaagtgac atgctctaag gtcaaaagtt 780 gcattcttct caaagggcaa ttcagacttt catcactccc tagtgagggc gcggagctag 840 atatgcaaag ggtttatata aatttatgtg atacattttt tttagttaat ctaaaatata 900 ataaaagctt ttttttttaa caagatcgat ttgaaatcac acaaatattt gtgaatttag 960 atcataaatt tcaaaaatct tttaataaaa ggctagcttc tgttcttggc cttttagagg 1020 ttaggtacat gctccatccc ctcctttctt gttgttacta tttgccatgg ccggtaggga 1080 tcagggtcaa accccaatgt atcacaggtc agtatagtcc gaccgtgaca attttctatg 1140 ggggattgtg tagaatcaaa tatctattca taaattgaga cattgagacg aatattcttc 1200 tttacattat tgagacgaaa aaaatattaa attttcttaa taaaaatctt agctccccac 1260 tatttagtct aggtttcata ttcaatgaat tgctggggtt tatgttatta ctcaactgaa 1320 ataaaaagag aattgtcgtt atccaggtta gacaaaagca cgtgtagttt caaacgcagt 1380 agccattatt ctcctctcct ttacaggtga gattcaaggg cagaaaggta ccatgcaagc 1440 tgttatttaa atttacttat tgattatgat cgacgacttt gacagaaaaa tgatgatgct 1500 ttaattttac gacctagcct ttctttttaa gaagaataaa aaacatacct cgatttggta 1560 taaatcaata gtttcgtcaa tcttaaaaac attcctttac ttgacttact aaatttaaat 1620 atatcttcga tctgccacat aacataacaa atggtttcaa acggaacata tgactcttaa 1680 taaaaggtgg agaagggttg aaaactttac taaatttaac aagatcttag gtgtgtattt 1740 gactcatgtt gcaagattga agtgtattta agttcagtta atcaagtaaa gagatatttt 1800 taaggttgtc aatatataat tcggagataa aactagcctt ttgtttcatt tgttgagttt 1860 aaaattaagt tgatatgaaa caacaaataa attgtgatcc caagttttat atgagcaaaa 1920 taaaatcaag cattgtatat ctctctttta tttttctccc tagtatccgc attggagccc 1980 gactatattc gaatcgcact ataggcttca tttttttcat actcgagtct taaatctgaa 2040 acctctgggt aagggtagaa tatcttatat ctcttttttt ttttttttgg attttccatt 2100 caacgtttgg tacccacatt gaagttcagt taattcaaat ttgcaccgca taggctaagc 2160 ggttcctacc aatgatcttt tcatacccag ggactcaaac acaagaagtt taattaagaa 2220 ataaatagtc tcatccgcta taccacattg tgatatatct cattaagata ccacattata 2280 tctatttatg ggggtagggg ggatgggtct agctagggtt gtggaaatga ggttagagag 2340 agagtggttt ttcagtgtgt gtgtcaggtg atatcacgtg aaggggcacg ataacaagtt 2400 gttcatatcc attcacttcc aagaataccg ctacgtacag tcactagctg ctttcttcct 2460 atccccatct ttgtcaaatt tcctttcctt ttccaattac tttttcttta atagacatgg 2520 acgcaattct tccttccttt ccccttcccc tatattcttc ctttatctct ctttcacaat 2580 aatagcacca tgcctgtagc ttgatgctta gacgggtgca cacgcactct ctcactcaca 2640 cagctagaat atatatatat atatatatat atattcatag ttagcagaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac caactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 99 <211> 3000 <212> DNA <213> Artificial Sequence <400> 99 aagctgattc ggtgggaaaa tcatgtttta tatcacaaat tttttaggtt gccgatccag 60 agaatttaaa tattaatgtt gtgaattcta atactccacc tgttttaaaa aatggtctag 120 tttgacttga aacggagttt aagaaaagaa aaaagacttt ctaatcttgt gattccaaat 180 taaagttatg tcaaatgtac caaaatgtcc tttaatcttg tggtcttaaa catgtcacgt 240 gaaaaattga agttaaagtg ttgcaaaaaa aaaaaggggt cattcttttt taaacaaact 300 aaaaaagaaa actaagtcat tccttttgaa acggaggatg tatactatat ttatatattt 360 ggttctcgca aacctgcaaa taagggcgga tgcacaacag aagttacgag tttgattaaa 420 tcttctaatt ttagtttaaa ctttgtatat atgcgtagag aagtcataaa gttcaaatac 480 tgaatttact aattttatca aagttgtgat ctactgctga ttaaagttgg gtgggcaggt 540 ggggatgccc ggtattgggg aatgtagtat actgtacatc taaaagcaat tttggcaaaa 600 ccatctctgt cactgatctc tcacttcaca atactaacat atagagttgg ggccaaagta 660 gtcatgtagt tgatgggaag agatagtacg gaggaatgga gaaaaaggta ggtgggtgag 720 ttgggggaag agatagggtt ctctttttag tgaaagtgac atgctctaag gtcaaaagtt 780 gcattcttct caaagggcaa ttcagacttt catcactccc tagtgagggc gcggagctag 840 atatgcaaag ggtttatata aatttatgtg atacattttt tttagttaat ctaaaatata 900 ataaaagctt ttttttttaa caagatcgat ttgaaatcac acaaatattt gtgaatttag 960 atcataaatt tcaaaaatct tttaataaaa ggctagcttc tgttcttggc cttttagagg 1020 ttaggtacat gctccatccc ctcctttctt gttgttacta tttgccatgg ccggtaggga 1080 tcagggtcaa accccaatgt atcacaggtc agtatagtcc gaccgtgaca attttctatg 1140 ggggattgtg tagaatcaaa tatctattca taaattgaga cattgagacg aatattcttc 1200 tttacattat tgagacgaaa aaaatattaa attttcttaa taaaaatctt agctccccac 1260 tatttagtct aggtttcata ttcaatgaat tgctggggtt tatgttatta ctcaactgaa 1320 ataaaaagag aattgtcgtt atccaggtta gacaaaagca cgtgtagttt caaacgcagt 1380 agccattatt ctcctctcct ttacaggtga gattcaaggg cagaaaggta ccatgcaagc 1440 tgttatttaa atttacttat tgattatgat cgacgacttt gacagaaaaa tgatgatgct 1500 ttaattttac gacctagcct ttctttttaa gaagaataaa aaacatacct cgatttggta 1560 taaatcaata gtttcgtcaa tcttaaaaac attcctttac ttgacttact aaatttaaat 1620 atatcttcga tctgccacat aacataacaa atggtttcaa acggaacata tgactcttaa 1680 taaaaggtgg agaagggttg aaaactttac taaatttaac aagatcttag gtgtgtattt 1740 gactcatgtt gcaagattga agtgtattta agttcagtta atcaagtaaa gagatatttt 1800 taaggttgtc aatatataat tcggagataa aactagcctt ttgtttcatt tgttgagttt 1860 aaaattaagt tgatatgaaa caacaaataa attgtgatcc caagttttat atgagcaaaa 1920 taaaatcaag cattgtatat ctctctttta tttttctccc tagtatccgc attggagccc 1980 gactatattc gaatcgcact ataggcttca tttttttcat actcgagtct taaatctgaa 2040 acctctgggt aagggtagaa tatcttatat ctcttttttt ttttttttgg attttccatt 2100 caacgtttgg tacccacatt gaagttcagt taattcaaat ttgcaccgca taggctaagc 2160 ggttcctacc aatgatcttt tcatacccag ggactcaaac acaagaagtt taattaagaa 2220 ataaatagtc tcatccgcta taccacattg tgatatatct cattaagata ccacattata 2280 tctatttatg ggggtagggg ggatgggtct agctagggtt gtggaaatga ggttagagag 2340 agagtggttt ttcagtgtgt gtgtcaggtg atatcacgtg aaggggcacg ataacaagtt 2400 gttcatatcc attcacttcc aagaataccg ctacgtacag tcactagctg ctttcttcct 2460 atccccatct ttgtcaaatt tcctttcctt ttccaattac tttttcttta atagacatgg 2520 acgcaattct tccttccttt ccccttcccc tatattcttc ctttatctct ctttcacaat 2580 aatagcacca tgcctgtagc ttgatgctta gacgggtgca cacgcactct ctcactcaca 2640 cagctagaat atatatatat atatatatat atattcatag ttagcagaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac caactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 100 <211> 3000 <212> DNA <213> Artificial Sequence <400> 100 tgttgtgaat tctaatactc cacctgtttt aaaaaatggt ctagtttgat taggaatgga 60 gtttaagaaa aaaaaaaaag attttctaat cttggagttc aaaattaaag ttatgttaaa 120 tgtaccaaaa tatcctttaa ttttgtggtc ctaaacatgt cacgtgaaaa attgaagcta 180 aagtgttacc aaaaaaagaa aggggtcatc ctttttgaaa caaacaaaaa aaaaactaag 240 tcattatttt ttaaacgaag aaagtatact atatttatat atttggttct cgcaaacctg 300 caaataaggg cggatgcaca acagaagtta cgagtttgat taaatctact aattttagtt 360 taaactttgt atatatgtgt aaaggagtca taaagttcaa atactgaatt tactaatttt 420 atcaaagttg tgatctactg ctaattaaag ttggatgggc aggtggggat gcccggtatt 480 ggggaatgta gtatactgta catctaaaag caattttggc aaaaccatct ctgtcactga 540 tctctcactt cacaatacta acatatagag ttggggccaa agtagtcatg tagttgatgg 600 gaagagatag tacggaggaa tggagaaaaa ggtaggtggg tgagttgggg gaagagatag 660 ggttctcttt ttagtgaaag tgacatgctc taaggtcaaa agttgcattc ttctcaaagg 720 gcaattcaga ccttcatcac tccctagtga gggcgaagag ctagatatgc aaaggattta 780 tataaattta tgtgatacgt tttttttatt taatctaaaa aataataagt tttttttttt 840 taccaagatc gatttgaaat cacacaaata tttgtgaatt tagatcaaat atttgtgaat 900 ttagatcata aatttcaaaa gtcttttaat aaaaggctag cttctgttct tggcctttta 960 gaggttaggt acatgctcca tcccctcctt acttgttgtt actatttgcc atggctggta 1020 gggatcaggg tcaaacccca atgtatcaca ggtcaatata gtccgaccgt gacaattttc 1080 tagggtgtat tgtatagaat caaatatcta ttcataaatt gagacattga gacgaatatt 1140 cttctttaca ttattgagac gaagataata ttaaattttc ttaataaaaa tcttagctcc 1200 tcactatttg gtctaggttt catattcaat gaattgctgg ggtttatgtt attactcaac 1260 tgaaataaaa agagaattgt cgttatccag gttagacaaa agcacgtgta gtttcaaacg 1320 cagtagccat tattctcctc tcctttacag gtgagattca agggcagaaa ggtaccatgc 1380 aagctgttat ttaaatttac ttattgatta tgatcgacga ctttgacaga aaaatgatga 1440 tgctttaatt ttacgaccta gcctttcttt ttaagaagaa taaaaaacat acctctattt 1500 ggtataaacc aatagtttcg tcaatcttaa aaacattctt ttacttgact cactaaattt 1560 aaatatatct tcgatctgcc acataacata acaaataatt tcaaactctt gtcaaaacat 1620 atgactctta ataaaaggtg gagaagggtt gaaaacttta ctaaatttaa caagatctta 1680 ggtgtgtatt tgactcatgt tgcaagattg aagtgtattt aagttcagtt agtcaagtaa 1740 aaagatattt ttaaggttgt caatatataa ttcggagata aaactaataa tgcacactga 1800 atttagaggg tgttttcgac acttttcttt tgtttcattt gttcagttta aaattaagtt 1860 gatatgaaac aacaaataaa ttgtgatccc aagttttata tgagcaaaat aaaatcaagc 1920 attgtatatc tctcttttat ttttttccct ggtgtccgca ttggagctcg actatattcg 1980 aatcatacta taagcttcat ttttttcata ctcaaggctt aaatctgaaa cctctgggta 2040 agggtagaaa atcttatatc tctttctttt ttttggattt ttcatctaac gtttggtacc 2100 cacattgaaa ttcaattaat tcaaatttgc gccgcatagg ctaagcggtt cctacaaatg 2160 atctttccat atccagggac tcaaacgcaa aatatttatt taagaaataa atagtctcat 2220 atgctatacc acatcagttg atagtgtgat atatctcatt aagataccac attatatcta 2280 tttaaggggg tggggggacg ggtctagcta gggttgtgga aatgaggtta gagagagggt 2340 ggtttttcag tgtgtgtgtc aggtgaaatc acgtgaaggg gcacgataac aagttgttca 2400 tatccattca cttccaagaa taccgctacg tacagtcact agctgctttc ttcctatccc 2460 catctttgtc aaatttcctt tccttttcca attacttttt ctttaataga catggacgca 2520 attcttcctt cctttcccct tcccctatat tcttccttta tctctctttc acaataatag 2580 caccatgcct gtagcttgat gcttagacgg gtgcacacgc actctcactc tcactcacac 2640 agctagaata tatatattca tatatatata ttcatagtta gcagaagtac ttatcctata 2700 ccaaaaacca tacaaataca ttgtatcaag tgctgtcata ctcaagcaaa agaaagaaaa 2760 gaacaagata tagtagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac taactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 101 <211> 3000 <212> DNA <213> Artificial Sequence <400> 101 ttcggaggga aaatcatgtt ttatatcaca aattttttag gttgccgatc cagagaattt 60 aaatattaat gttgtgaatt ctaatactcc acctgtttta aaaaatgatc tagtttgact 120 tgaaacggag tttaagaaaa gaaaaaagac tttctaatct tgtgattcca aattaaagtt 180 atatcaaatg taccaaaatg tcctttaatc ttgtggtctt aaatatgtca cgtgaaaaat 240 tgaagttaaa gtgttgccaa aaaaagaaag gggtcattct tttttaaaca aactaaaaaa 300 gaaaactaag tcattccttt tgaaacggag gaagtatact atatttatat atttggttct 360 cgcaaacctg caaataaggg cggatgcaca acagaagtta cgagtttgat taaatcttct 420 aattttagtt taaactttgt atatatgcgt agagaagtca taaagttcaa atactgaatt 480 tactaatttt atcaaagttg tgatctactg ctgattaaag ttgggtgggc aggtggggat 540 gcccggtatt ggggaatgta gtatactgta catctaaaag caattttggc aaaaccatct 600 ctgtcactga tctctcactt cacaatacta acatatagag ttggggccaa agtagtcatg 660 tagttgatgg gaagagatag tacggaggaa tggagaaaaa ggtaggtggg tgagttgggg 720 gaagagatag ggttctcttt ttagtgaaag tgacatgctc taatgtcaaa agttgcattc 780 ttctcaaagg gcaattcaga ctttcatcac tccctagtga gggcgcggag ctagatatgc 840 aaagggttta tataaattta tgtgatacat tttttttagt taatctaaaa aataataaaa 900 gctttttttt tttaccaaga tcgatttgaa atcacacaaa tatttgtgaa tttagatcat 960 aaatttcaaa agtcttttaa taaaaggcta ccttctgttc ttggcctttt agaggttagg 1020 tacatgctcc atcccctcct ttcttgttgt tactatttgc catggccggt agggatcagg 1080 gtcaaacccc aatgtatcac aggtcagtat agtccgaccg tgacaatttt ctatggggga 1140 ttgtgtagaa tcaaatatct attcataaat tgagacattg agacgaatat tcttctttac 1200 attattgaga cgaaaaaaat attaaatttt cttaataaaa atcttagctc cccactattt 1260 agtctaggtt tcatattcaa tgaattgctg gggtttatgt tattactcaa ctgaaataaa 1320 aagagaattg tcgttatcca ggttagacaa aagcacgtgt agtttcaaac gcagtagcca 1380 ttattctcct ctcctttaca ggtgagattc aagggcagaa aggtaccatg caagctgtta 1440 tttaaattta cttattgatt atgatcgacg actttgacag aaaaatgatg atgctttaat 1500 tttacgacct agcctttctt tttaagaaga ataaaaaaca tacctcgatt tggtataaat 1560 caatagtttc gtcaatctta aaaacattct tttacttgat ttattaaatt tagatatatc 1620 ttcgatctgc cacataacat aacaaatggt ttcaaacgga acatatgact cttaataaaa 1680 ggtggagaag ggttgaaaac tttactaaat ttaacaagat cttaggtgtg tatttgactc 1740 atgttgcaag attgaagtgt atttaagttc agttaatcaa gtaaatagat atttttaagg 1800 ttgtcaatat ataattcgga gataaaacta gccttttgtt tcatttgttg agtttaaaat 1860 taagttgata tgaaacaaca aataaattgt gatcccaagt tttatatgag caaaataaaa 1920 tcaagcattg tatatctctc ttttattttt ctccctggta tccgcattgg agcctgacta 1980 tattcgaatc gcactatagg cttcattttt ttcatactcg aggcttaaat ctgaaacctc 2040 tgggtaagga tagaatatct tatatctctt tttttttttt tttggatttt ccattcaacg 2100 tttggtacgc aaattgaagt tcagttaatt caaatttgca ccgcataggc taagcggttt 2160 ctaccaatga tcttttcata cccagggact caaacacaag acgtttaatt aagaagtaaa 2220 tagtctcatc cgctatacca cattgtgtgg tgatatatct cattaagata ccacattata 2280 tctatttaag ggggtagggg ggatgggtct agctagggtt gtggaaatga ggttagagag 2340 agagtggttt ttcagtgtgt gtgtcaggtg atatcacgtg aaggggcacg ataacaagtt 2400 gttcatatcc attcacttcc aagaataccg ctacgtacag tcactagctg ctttcttcct 2460 atccccatct ttgtcaaatt tcctttcctt ttccaattac tttttcttta atagacatgg 2520 acgcaattct tccttccttt ccccttcccc tatattcttc ctttatctct ctttcacaat 2580 aatagcacca tgcctgtagc ttgatgctta gacgggtgca cacgcactct ctcactcaca 2640 cagctagaat atatatatat atatatatat atattcatag ttagcagaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac caactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 102 <211> 3000 <212> DNA <213> Artificial Sequence <400> 102 gttttatatc acaaattttt taggttgccg atccagagaa tttaaatatt aatgttgtga 60 attctaatac tccacctgtt ttaaaaaatg gtctagtttg acttgaaacg gagtttaaga 120 aaagaaaaaa gactttctaa tcttgtgatt ccaaattaaa gttatgtcaa atgtaccaaa 180 atgtccttta atcttgtggt cttaaacatg tcacgtgaaa aattgaagtt aaagtgttgc 240 caaaaaaaga aaggggtcat tctttttgaa acaaactaaa aaagaaaact aagtcattcc 300 ttttgaaacg gaggaagtat actatattta tatatttggt tctcgcaaac ctgcaaataa 360 gggcgaatgc acaacagaag ttacgagttt gattaaatct tctaatttta gttaaaactt 420 tgtatatatg cgtagagaag tcataaagtt caaatactga atttactaat tttatcaaag 480 ttgtgatcta ctgctaatta aagttgggtg ggcaggtggg gatgcccggt attggggaat 540 gtagtatact gtatatctaa aagcaatttt ggcaaaacca tctctgtcac tgatctctca 600 cttcacaata ctaacatata gagctggggc caaagtagtc atgtagttga tgggaagaga 660 tagtacggag gaatggagaa aaaggtaggt gggtgagttg ggggaagaga tagggttctc 720 tttttagtga aagtgacatg ctctaaggtc aaaagttgca ttcttctcaa agggcaattc 780 agactttcat cactccctag tgagggcgag gagctagata tgcaaagggt ttatataaat 840 ttatgtgata catttttttt agttaatcta aaaaaaagaa taaaagtttt ttttttttac 900 caagatcgat ttgaaatcac acaaatattt gtgaatttag atcataaatt tcaaaagtct 960 tttaataaaa ggctagcttc tgttcttagc cttttagagg ttaggtacat gctccatccc 1020 ctcctttatt gttgttacta tttgccatgg ccggtaggga tcagggtcaa accccaatgt 1080 atcacaggtc agtatagtcc gaccgtgaca attttctatg ggggattgtg tagaatcaaa 1140 tatctattca taaattgaga cattgagacg aatattcttc tttacattat tgagacgaaa 1200 aaaatattaa attttcttaa taaaaatctt agctccccac tatttagtct aggtttcata 1260 ttcaatgaat tgctggggtt tatgttatta ctcaactgaa ataaaaagag aattgtcgtt 1320 atccaggtta gacaaaagca cgtgtagttt caaacgcagt agccattatt ctcctctcct 1380 ttacaggtga gattcaaggg cagaaaggta ccatgcaagc tgttatttaa atttacttat 1440 tgattatgat cgacgacttt gacagaaaaa tgatgatgct ttaattttac gacctagcct 1500 ttctttttaa gaagaataaa aaacatacct caatttggta taaaccaata gtttcgtcaa 1560 tctaaaaaat attcttttac ttgactcact aaatttagat atatcttcga tctgccacat 1620 aacataacaa atgatttcaa acttttgtcg gaacatatga cttaataaaa ggtggagaag 1680 ggttgaaaac tttactaaat ttaacaagat cctaggtgtg tatttgactc atgttgcaag 1740 attgaagtgt atttaaattt agttagtcaa gtaaagatat atttttaagg ttgtcaatat 1800 ataattcaga aataaaacta ataattcaca ctgaatttag ggggtgtttt caatactctt 1860 cttttgtttc atttcttgag tttaaaatta agttgatacg gaacaacaaa taaattgtga 1920 tcccaagttt tatatgagca aaataaaatc aagcattgta tatctctctt ttatttttct 1980 ccctggtgtc cgcattgttg cccgactata ttcgattcgc actataggct tcattttttt 2040 tcatactcag ggcttaaatc tgaaatctgt gggtaagggt agaatatctt atatctcttt 2100 tttttttttt ttatagattt tccatccaac gtttgttacc cacattgaag ttcaattaat 2160 tcaaatttgc gccgcataag ctaagcggtt cctaccaatg atctttccat acccagggac 2220 tcaacgcaaa acatttattt aagaaataaa tagtctcatc cgctatatag tgtatctcat 2280 taagatacca cattatatct atttaagggg gtagggggga tgggtctagc tagggttgtg 2340 gaaatgaggt tagagagagg gtggtttttc agtgtgtgtg tcaggtgaaa tcacgtgaag 2400 gggcacgata acaagttgtt catatccatt cacttccaag aataccgcta cgtacagtca 2460 ctagctgctt tcttcctatc cccatctttg tcaaatttcc tttccttttc caattacttt 2520 ttctttaata gacatggacg caattcttcc ttcctttccc cttcccctat attcttcctt 2580 tatctctctt tcacaataat agcaccatgc ctgtagcttg atgcttagac gggtgcacac 2640 gcactctctc actcacacag ctagaatata tatattcata gttagcagaa gtacttttca 2700 tataccaaaa accatacaaa tacattgtat caagtgctgt catactcaag caaaagaaag 2760 aaaagaacaa gatatagtac taccgttttc atcaccattt tggtcaatca tgatgattct 2820 gaacaaagat atagtactag ctaggtagaa aataaatcta ctaactttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagtagcaa aatcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 103 <211> 3000 <212> DNA <213> Artificial Sequence <400> 103 attttttagg ttgccgatcc agagaattta aatattaatg ttgtgaattc taatactcca 60 cctgttttaa aaaatggtct agtttgactt gaaacagagt ttaagaaaag aaaaaagact 120 ttctaatctt gtgattccaa attaaagtta tgtcaaatgt accaaaatgt cctttaatct 180 tgtggtctta aacatgtcac gtgaaaaatt gaagttaaag tgttgccaaa aaaagaaagg 240 gttcattctt tttgaaacaa actaaaaaag aaaactaagt cattcctttt gaaacggagg 300 aagtatacta tatttatata tttggttctc gcaaacctgc aaataagggc ggatgcacaa 360 cagaagttac gagtttgatt aaatcttcta attttagttt aaactttgta tatatgcgta 420 gagaaagtca taaagttcaa atactgaatt tactaatttt atcaaagttg tgatctactg 480 ctgattaaag ttgggtgggc aggtggggat gcccggtatt ggggaatgta gtatactgta 540 catctaaaag caattttggc aaaaccatct ctgtcactga tctctcactt cacaatacta 600 acatatagag ttggggccaa agtagtcatg tagttgatgg gaagagatag tacggaggaa 660 tggagaaaaa ggtaggtggg tgagttgggg gaagagatag ggttctcttt ttagtgaaag 720 tgacatgctc taaggtcaaa agttgcattc ttctcaaagg gcaattcaga ctttcatcac 780 tccctagtga gggcgcggag ttagatatgc aaagggttta tataaattta tgtgatacat 840 tttttttagt taatctaaaa aataataaaa gctttttttt ttaccaagat cgatttgaaa 900 tcacacaaat atttgtgaat ttagatcata aatttcaaaa gtcttttaat aaaaggctag 960 cttctgttct tggcctttta gaggttaggt acatgctcca tcccctcctt tcttgttgtt 1020 actatttgcc atggccggta gggatcaggg tcaaacccca atgtatcaca ggtcagtata 1080 gtccgaccgt gacaattttc tatgggggat tgtgtagaat caaatatcta ttcataaatt 1140 gagacattga gacgaatatt cttctttaca ttattgagac gaaaaaaata ttaaattttc 1200 ttaataaaaa tcttagctcc ccactattta gtctaggttt catattcaat gaattgctgg 1260 ggtttatgtt attactcaac tgaaataaaa agagaattgt cgttatccag gttagacaaa 1320 agcacgtgta gtttcaaacg cagtagccat tattctcctc tcctttacag gtgagattca 1380 agggcagaaa ggtaccatgc aagctgttat ttaaatttac ttattgatta tgatcgacga 1440 ctttgacaga aaaatgatga tgctttaatt ttacgaccta gcctttcttt ttaagaagaa 1500 taaaaaacat acctcgattt ggtataaatc aatagtttcg tcaatcttaa aaacattctt 1560 ttacttgact tactaaattt agatatatct tcgatctgcc acataacata acaaatggtt 1620 tcaaacggaa catatgactc ttaataaaag gtggagaagg gttgcaaact ttactaaatt 1680 taacaagacc ttaggtgtgt atttgactca tgttgcaaga ttgaagtgta tttaagttta 1740 gttagtcaag taaagatgta tttttaaggt tgtcaatata taattcgaag ataaaactaa 1800 taattcatgc tgaatttagg aggtgttttc aatacttttc ttttgtttca tttgttgagt 1860 ttaaaattaa gttgatatga aacaacaaat aaattgtgat cccaagtttt atatgagcaa 1920 aataaaatca agcattgtat atctctcttt tatttttctc cctggtatcc gcattggagc 1980 ccgactatat tcgaatcgca ctataggctt catttttttc atactcgagg cttaaatctg 2040 aaacctctgg gtaagggtag aatatcttat atctctttct tttctttttt tggattttcc 2100 attcaacgtt tggtacccac attgaagttc agttaattca aatttgcgcc gcacaggcta 2160 agcggttcct accaatgatc ttttcatacc aagggactca aacacaagac gtttaattaa 2220 gaaataaata gtctcatccg ctatagcaca ttgtgatata tctcattaag ataccacatt 2280 atatctattt aagggggtag gggggatggg ttagctaggg ttgtggaaat gaggttagag 2340 agagagtggt tttcagtgt gtgtgtcagg tgatatcacg tgaaggggca cgataacaag 2400 ttgttcatat ccattcactt ccaagaatac cgctacgtac agtcactagc tgctttcttc 2460 ctatccccat cttttgtcaaa tttcctttcc ttttccaatt actttttctt tatagacat 2520 ggacgctatt cttccttcct ttccccttcc cctatattct tcctttatct ctctttcaca 2580 aatatagcac catgcctgta gcttgatgct tagacgggtg cacacgcact ctctcactca 2640 cacagctaga father father father father father agttagcaga agtacttatc 2700 atataccaaa aaccacacaa atacattgta tcaagtgctg tcatactcaa gcaaaagaaa 2760 gaaaagaaca agatatagta ctactgtttc atcaccaatt tggtcaatca tgatgattct 2820 gaacaaagat atagtactag ctaggtagaa aataaatcta ctaactttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagtagcaa aatcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 104 <211> 3000 <212> DNA <213> Artificial Sequence <400> 104 gattcggagg gaaaatcatg ttttatatca caaatttttt aggttgccga tccagagaat 60 ttaaatatta atgttgtgaa ttctaatact ccacctgttt taaaaaatga tctagtttga 120 cttgaaacgg agtttaagaa aagaaaaaag actttctaat cttgtgattc caaattaaag 180 ttatatcaaa tgtaccaaaa tgtcctttaa tcttgtggtc ttaaatatgt cacgtgaaaa 240 attgaagtta aagtgttgcc aaaaaaagaa aggggtcatt cttttttaaa caaactaaaa 300 aagaaaacta agtcattcct tttgaaacgg aggaagtata ctatatttat atatttggtt 360 ctcgcaaacc tgcaaataag ggcggatgca caacagaagt tacgagtttg attaaatctt 420 ctaattttag tttaaacttt gtatatatgc gtagagaagt cataaagttc aaatactgaa 480 tttactaatt ttatcaaagt tgtgatctac tgctgattaa agttgggtgg gcaggtgggg 540 atgcccggta ttggggaatg tagtatactg tacatctaaa agcaattttg gcaaaaccat 600 ctctgtcact gatctctcac ttcacaatac taacatatag agttggggcc aaagtagtca 660 tgtagttgat gggaagagat agtacggagg aatggagaaa aaggtaggtg ggtgagttgg 720 gggaagagat agggttctct ttttagtgaa agtgacatgc tctaatgtca aaagttgcat 780 tcttctcaaa gggcaattca gactttcatc actccctagt gagggcgcgg agctagatat 840 gcaaagggtt tatataaatt tatgtgatac atttttttta gttaatctaa aaaataataa 900 aagctttttt tttttaccaa gatcgatttg aaatcacaca aatatttgtg aatttagatc 960 ataaatttca aaagtctttt aataaaaggc taccttctgt tcttggcctt ttagaggtta 1020 ggtacatgct ccatcccctc ctttcttgtt gttactattt gccatggccg gtagggatca 1080 gggtcaaacc ccaatgtatc acaggtcagt atagtccgac cgtgacaatt ttctatgggg 1140 gattgtgtag aatcaaatat ctattcataa attgagacat tgagacgaat attcttcttt 1200 acattattga gacgaaaaaa atattaaatt ttcttaataa aaatcttagc tccccactat 1260 ttagtctagg tttcatattc aatgaattgc tggggtttat gttatactc aactgaaata 1320 aaaagagaat tgtcgttatc caggttagac aaaagcacgt gtagtttcaa acgcagtagc 1380 cattattctc ctctccttta caggtgagat tcaagggcag aaaggtacca tgcaagctgt 1440 tatttaaatt tacttattga ttatgatcga cgactttgac agaaaaatga tgatgcttta 1500 attttacgac ctagcctttc tttttaagaa gaataaaaaa catacctcga tttggtataa 1560 atcaatagtt tcgtcaatct taaaaacatt cttttacttg atttattaaa tttagatata 1620 tcttcgatct gccacataac ataacaaatg gtttcaaacg gaacatatga ctcttaataa 1680 aaggtggaga agggttgaaa actttaactaa atttaacaag atcttaggtg tgtatttgac 1740 tcatgttgca agattgaagt gtatttaagt tcagttaatc aagtaaaatag atatttttaa 1800 ggttgtcaat atataattcg gagataaaac tagccttttg tttcatttgt tgagtttaaa 1860 attaagttga tatgaaacaa caaataaatt gtgatcccaa gtttatatg agcaaaataa 1920 aatcaagcat tgtatatctc tcttttattt ttctccctgg tatccgcatt ggagcctgac 1980 tatattcgaa tcgcactata ggcttcattt ttttcatact cgaggcttaa atctgaaacc 2040 tctgggtaag gatagaatat cttatatctc tttttttttt tttttggatt ttccattcaa 2100 cgtttggtac gcaaattgaa gttcagttaa ttcaaatttg caccgcatag gctaagcggt 2160 ttctaccaat gatcttttca tacccaggga ctcaaacaca agacgtttaa ttaagaagta 2220 aatagtctca tccgctatac cacattgtgt ggtgatatat ctcattaaga taccacatta 2280 tatctattta agggggtagg ggggatgggt ctagctaggg ttgtggaaat gaggttagag 2340 agagagtggt ttttcagtgt gtgtgtcagg tgatatcacg tgaaggggca cgataacaag 2400 ttgttcatat ccattcactt ccaagaatac cgctacgtac agtcactagc tgctttcttc 2460 ctatccccat ctttgtcaaa tttcctttcc ttttccaatt actttttctt taatagacat 2520 ggacgcaatt cttccttcct ttccccttcc cctatattct tcctttatct ctctttcaca 2580 ataatagcac catgcctgta gcttgatgct tagacgggtg cacacgcact ctctcactca 2640 cacagctaga atatatatat atatatatat atattcatag ttagcagaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac caactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 105 <211> 3000 <212> DNA <213> Artificial Sequence <400> 105 atgggagaaa cctttatttc taatagtgcg tgctgttacg ttgccgatca gagaatttaa 60 atattaatgt tgtgaattct aatattccct ccgtttaaaa aagaatggtt tagtttaact 120 tggaacggag tttaacaaaa gaaagaaaac tttttaatct tatggttcta aattaaagtt 180 atgtcaaatg taccaaaatg ctctttaatc ttgtggtcct aaacatgtca cgtgataaat 240 tgaagctaaa gtgttgccaa aaaaagatag ggatcattct tttttaaata aacaaaaaaa 300 gaaactaagt catttttttt ttaaatggag aaaatatatt atatttatat atttggttct 360 cgcaatcctg caaataaggg cggatgcgca atagaagtta cgagtttgat taaatctact 420 aaatttattt taaactttgt atatatgtgt agagaagtca tatagttcaa atactgaatt 480 tactgatttt atcgaagttg tgatctactg ctaattaaag ttgggtgggc aggtgaggat 540 acccggtatt gaggaatatt gtatactgta catctaaaag caatttaggc aaaaccatct 600 ctgtcactga tctctcactt cacaatacta acagatagag ttggggccaa agtagtcatg 660 tagttgatgg gaagagatag tacggaggaa tggagaaaaa ggtaggtggg tgagttgggg 720 gaagagatag ggttctcttt ttagtgaaag tgacatcctc taaggtcaaa agttgcattc 780 ttctcaaagg gcaattcaga ctttcatcac tccctagtga tggcgtggag ctaaatatgc 840 aaggggttta tatagattta tgtgatatat tttttttaat taatctaaaa aagaatataa 900 gttctttttt ttaccaagat caatttgaaa tcacacaaat atttgtgaat ttatattata 96O aatttcaaaa gtcttttaat aaaaggctag cttctgtttt tggcctttta gaggttggta 1020 catgctccat cccctccttc cttgctgtta ctatttgcca tggccggtag ggatcaaggt 1080 caaaccccaa tgcatcgcag gtcaatatag cccgaacagt gacaattttc tagaggggga 1140 ttgtgtagaa tcaaatatct attcataaat tgagacgaat attcttcttt acattattga 1200 gacgaaaaaa atattaaatt ttcttaataa aaatcttagc tcctcactat ttagtctagg 1260 tttcatattc attgtattgc tgggctttat gttattacac aactgaaata aaaagagaat 1320 tgtcgttatc caggttagac aaaagcacgt gtagtttcaa acgcagtagc cattattctc 1380 ctctccttta caggtgagat tcaagggcag aaaggtacca tgcaagctgt tatttaaatt 1440 tacttattga ttatgatcga cgactttgac agaaaaatga tgatgcttta attttgcgac 1500 ctagcctttc tttttaagaa gtataaaaaa catacatcaa tttggtataa atcaatagtt 1560 tcttcaatct taaaagtatt tttttagttg actcactaga tatatcttca atctatcaca 1620 taacatagca aatgatttca aatttttgtc gaaacatatg actcttaata aaaggtggag 1680 aagggttgaa aactttacta aatttaacaa gatcttagag gtgtatttga ctcatgttgt 1740 aagattgaag tgtatttaag ttcagttaat caaataaacg ggtaatttta aggttgtcaa 1800 catataattc ggagatgaaa ctaataattc acactaaatt taggggatgt tttcgatact 1860 tttcttttgt ttcatttgtt gagtttaaaa ttaagttgat atgaaacaac aaataacttg 1920 tgatcccaag ttttatatca gcaaaataaa atcaagcatt gtatatctct cttttatttt 1980 tctccctggt gtccgcattg gagcccgact atattcaaat cacactatag gcttcatttt 2040 tttcatactc agagcttaaa tctgaaatct ctaggtaagg gtagaatatc ttatatctct 2100 ttcttttttc tttttttttt ttgaattttc catccaacgt ttgataccca ccttgaagtt 2160 cagttaattc aaatttgcgc cccataggct aagcaattcc taccaatgat ctttccatac 2220 ctagggactc aaacgtcttt taagaaataa ataatctcat ccgctatacc atatcactta 2280 atagcgtggt ataataccac attatatcta tttaaggggg tagggggatg ggtctagcta 2340 gggttgtgga aaggaggtta gagagagaga ggtttttcag tgtgtgtgcg tgtcaggtga 2400 tatcacgtga aggggcacga taacaagttg ttcgtatgta ttcacttcca agaataccgc 2460 tacgtaccac tagctacttc cttcctatcc gcatctttgt caaatttcct ttccttttcc 2520 aattactttt tgttttatag acatggacgc atttcttcct tcctttcccc ttcccctata 2580 ttcttcttcc tttatctctc tttcacaatc atagcaccat gcctgtagct tgacggtgca 2640 cgcgcactct cactcacaca gctagaatat atatattcat agttagcaga agtacttatc 2700 atataccaaa aaccacacaa atacattgta tcaaatgctg tcatactcaa gcaaaagaaa 2760 gaaaagaaca agatatagta caactgtttt catcaccatt tcggtcaatc atgatgattc 2820 tgaacaagat atagtactag ctaggtagaa aataaatcta ctaactttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagcagcaa aatcaaaaga ggttttaact gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 106 <211> 3000 <212> DNA <213> Artificial Sequence <400> 106 attgaatgtt taagaaagaa aatcaaataa ttttcgtcaa tttattttca tgcaaaaata 60 cagagaaata tcaaaaaaat aatattattt gtttgaaatt ttttatgttc gttcgcgaat 120 gtttaatttt ttaattaaca ggcacacatc tattttttaa aaataagaaa ttgcaattga 180 agaacataaa taaaaataaa tcataaaaat tagtataagt gtttaaatgg tacataaaaa 240 atgaagttta agaattaaaa tggaacaaga ctaagttaaa gtgccaaaat aaaaaataag 300 gacaaatttg aggggctgta tatgtgtttg ggcttttatc aaagttgtga tctactgcta 360 attaaagttg ggtgggcagg tgaggatgcc tggtattggg gaatatagta tactgtacat 420 ctaaaagcaa ttgaggcaaa accatctctg tcactgatct ctcacttcac aatactaaca 480 tatagagttg gggccaaagt agtcatgtag ttgatgggaa gagatagtac ggaggaatgg 540 agaaaaaggt aggtgggtga gttgggggaa gagatagggt tctcttttta gtgaaagtga 600 catgctctaa ggtcaaaagt tgcattcttc tcaaagggca attcagacct tcatcactcc 660 ctagtgaggg cgcggagcta gatatgcaag gggtttatat aaatttatgt gatacatttt 720 ttttaagtta atctaaaaag caataaaagt tttttttttt accaagattg atttgaaatc 780 acacaaatat ttataaattt agattaataa aaggctaact tctgttcttg gccttttaga 840 ggttaggtac atgctccatc ccctccttcc ttgttgttac tatttgccat ggccggtagg 900 gatcaagtca aaccccaatg catcacatgc cagtatagtc cgaacggtga cagttttcta 960 ggagggattg tgtagaatca aacactaaaa gaaaaatgta aattacatga gaatttttct 1020 agggattaat ataaaattta tagaaaaata agttttctac agattttcat actaatccct 1080 caaaaaaatt ctcatgtaat tcacactttt tttatagtga aatatctatt cataaattga 1140 gacattgaga cgaatattct tctttgcatt attgagacga agaaaatatt aaattttctt 1200 tataagaatc ttagctcctc actatttagt ctaggtttca tattcattga attgctgtta 1260 ttactcaact gaaataaaaa gagaattgtc gttatccagg ttagacaaaa gcacgtgtag 1320 tttcaaacgc agtagccatt attcccctct cctttacagg tgagattcaa gggcagaaag 1380 gtaccatgca agctgttatt taaatttact tattgattat gatcgacgac tttgacagaa 1440 aaatgatgat gctttaattt tgcgacctag cctttctttt taagaagtat aaaaatcata 1500 cctcaatttg gtataaatca atagttttgt caatcttaaa aagcattttt ttacttgact 1560 cactaaattt aaatatatct tcgatatgtc acatttcaaa ctcttgtcga aacatgactt 1620 ttaattaaag gtggagaagg gttgaaaact ttactaaatt taacaagatc ttaggggtgt 1680 attcgactca taatgcaaga ttgaagtgta tttaagttca gttagtcaag taaagggata 1740 tttttaaggt tgtcaatata taattcggag ataaaactaa taattcacac tgaatttagg 1800 gggtgttttc gatacttttc ttttgtttca tttgttgagt ttaaaattaa gttgatatga 1860 aacaataaat aaattgtgac cccaagtttt atatcagcaa aataaaatca agcattgtat 1920 atctctcttt tatttttctc cctggtgtcc gcattggaac ccgattatat tcaaatcgca 1980 ctataagctt catttttttc atactgagga cttaaatctg aaacctctag ataagggtag 2040 aatatcttat atctctttct ttattcttgt tttttggatt ttccatccaa cgtttggtat 2100 ccacattgaa gtttagttga ttcaatttgc accgcatagg ctaagcggtt cccaccaatg 2160 atctttccat acccagaaac tcaaacacaa aacgtttgtt taagaaataa atagtaccat 2220 cggctatacc acatcacttg atagtgtggt atatctcatt aagataccag attatatcta 2280 tttaaggggg tggggtgggg tggggtggcg tgcggggatg ggtctagcaa gagttgtgga 2340 aaggaggtta gagagagagt ggtttttcag tgtgtgtgtc aggtgatatc acgtgaagca 2400 cgataacaag ttgttcatat ccattcactt ccaagaatac cgctacgtac cacttgctac 2460 ttccttccta tccccatctt tgtcaaattt cctttccttt tccaattact ttttctttaa 2520 tagacatgga cgcaattctt ccttcctttc cccttcccct atattcttcc tttaactctc 2580 tttcacaata atagcaccat gcctgtagct tgatgcttag acgggtgcac acacactctc 2640 actcacacag ctagaatata tatattcata gttagcacaa gtacttatat catatatacc 2700 aaaaaccaca caaatacatt gtatcaagtg ctgtcatact caagcaaaaa aaaaaagaaa 2760 agaacaagat atagtactac tgttttcatc accattttgg tcaatcatga taattctgaa 2820 caagatatag tactagctag ctaggtagaa aataaatcta ctaactttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagcagcaa aatcaaaaga tgtgttagct gtgtttatac 2940 cgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 107 <211> 3000 <212> DNA <213> Artificial Sequence <400> 107 aagaatggtc tagtttaact tgaaacggag tttaacaaaa gaaaaaagac tttttaatct 60 tgtggttcta aaataaagtt gtgtcaaatg taacaaaatg ctctttaatc ttgtggtcct 120 aaacatgtca catgaaaagt tgaagctaaa gtgttgccaa aaaaagaaag agatcattct 180 ttttgaaaca aacaaaaaag gaaactaagt catttttttt aaaaggaatg aagtatacaa 240 tatttatata tttggttctc gcaaacctgc aaataagggc ggatgcacaa tagaagttac 300 gagtttgatt aaatatacta attttagttt aaattttgta tatatgtgta gagaagtcat 360 aaagttcaaa tactgaattt actaatttta tcaaagttgt gatctactgc taattaaagt 420 tgggtgggca ggtgaggatg cctggtattg gggaatatag tatactgtac atctaaaagc 480 aattgaggca aagccatctc tgtcactgat ctctcacttc acaatactaa caaatagagt 540 tggggccaaa gtagtcatgt agttgatggg aagagatagt acggaggaat ggagaaaaag 600 gtaggtgggt gagttggggg aagagatagg gttctctttt tagtgaaagt gacatgctct 660 aaggtcaaaa gttgcattct tctcaaaggg caattcagac cttcatcact ccctagtgag 720 ggggcggagc tagatatgca aggggtttat ataaatttat gtgatacatt tttttttagt 780 taatctaaaa aagaataaaa gttttttttt tttttaccaa tttgaaatca cacaaatatt 840 tataaattta gatcataaat ttcaaaagtc ttataataaa aggctagctt atgttcttag 900 cattttagag gttaggtaca tgctccatcc cctccttcct tgttgttact atttggcatg 960 gctggtaggg atcaaggtca aaccccaatg catcacaagt cagtatagtc cgaccggtga 1020 caattttcta ggggggatcg tgtagaatca aacactacaa gaaaaatgtg aattacatga 1080 gaatttttta gggattaata tgaaaatttg cagaaaaata agttttctac agattttcat 1140 actaatctcc aagaaaattc tcatgtaatt cacacttttt ttatagtgaa atatctattc 1200 ataaattgag acattgagac gaatattcta ctttacatta ttgagacaaa gaaaatatta 1260 ataagaatct tagctcctca ctatttagtc taggtttcat attcattgaa ttgctggggt 1320 ttatgttatt actcaactga aataaaaaga gaattgtcgt tatccaggtt agacaaaagc 1380 acgtgtagtt tcaaacgcag tagccattat tcccctctcc tttacaggtg agattcaagg 1440 gcagaaaggt accatgcaag ctgttattta aatttactta ttgattatga tcgacgactt 1500 tgacagaaaa atgatgatgc tttaattttg cgacctagcc tttcttttta acaagaataa 1560 aaaacatacc tcaatttggt ataaatcaat agtttcgtca atcttaaaag cattttttta 1620 cttgactcac taaatttaaa tatatcttcg atatgccaca tttcaaactc ttgtcgaaac 1680 atatgactga agggttgaaa attttactaa atttaacaag atcttagggg tgtatttgac 1740 tcataatgca agattgaagt gcatttaagt tcagttagtc aagtaaagag atatttttaa 1800 ggttgtcaat atataattcg gagataaaac taataattca cactgaattt agggggtgtt 1860 ttcgatactt ttcttttgtt tcatttgttg agtttaaaat taagttgata tgaaacaaca 1920 aataaattgt gatcccaagt tttatatcag caaaataaaa tcaagcatcg tatatctctc 1980 ttttattttt ctccctggtg tctgcattgg aacccgacta tattcaaatc gcattatagg 2040 ctttattttt ttcatactta gggcttaaat ctgaaacctc tagatcaggg taaaatatct 2100 tatctctttt tttttttctc catccaacgt ttgatatcca cattgaagtt caattgattt 2160 aaatttgcac cgcataggct aagcggttcc taccaatgat ctttccatac ccagaaactc 2220 aaacgcaaaa catttgttta agaaataaat agttccatcc gctataccac atcacttgat 2280 agtgtggtat atctaattaa gataccacat tatatctatt taagggggta gggtggggga 2340 tgggtctagc taggtttgtg gaaaggaggt tagagagaga gtggtttttc agtgtgtgtg 2400 tcaggtgata tcacgtgaag gggcacgata acaagttgtt catatccatt cacttccaag 2460 aataccgcta cgtaccacta gctgcttcct tcctatcccc atctttgtca aatttccttt 2520 ccttttccaa ttactttttc tttaatagac atggacgcaa ttcttccttc ctttcccctt 2580 cccctatatt cttcttcctt tatctctctt tcacaataat agcaccatgc ctgtagcttg 2640 acactctcac tcacacagct agaatatata tatagttagc agaagtactt atcatatata 2700 ccaaaaacca cacaaataca ttgtatcaag tgctgtcata ctcaagcaaa aaaaagaaaa 2760 gaacaagata tagtactact gttttcatca ccatttgggt caatcatgat aattctgaac 2820 aagatatagt actagctagc taggcagaaa ataaatctac atttgtttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagcagcaa aatcaaaaga ggttttagct gtgtttatac 2940 cgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 108 <211> 3000 <212> DNA <213> Artificial Sequence <400> 108 tccagagaat ttaaataata atgttgtgaa ttctaatact ccacctgttt taaaaaatag 60 tctagtttga cttggaacgg agtttaagaa aagaaaaaag attttctaat cttatggttc 120 caaattaaag ttatgtcaaa tgtaccaaaa tgccctttaa tcttgtggtt ctaaacatat 180 cacgtgaaaa cttgaagcta aagtgttgcc aaaaaaagaa agggatcatt ctttttgaaa 240 caaacaaaaa agaaaactaa gtcatttttt tttaaacgga gaaagtatac tatatttata 300 tatttggttc tcgcaaacct gcaaataagg gcggatgcac aacagaagtt acgagtttga 360 ttaaatctac taattttagt ttaaactttg tatatatgtg tagaggagtc ataaagttca 420 aatactgaat ttactaattt tatcaaagtt gtgatctgct gctaattaaa gttgagtggg 480 caggtgggga tgcccggtat tggggaatgt agtatactgt acatctaaaa gcaattttgg 540 caaaaccatc tctgtcactg atctctcact tcacaatact taacatatag agttggggcc 600 aaagtagtca tgtagttgat gggaagagat agtacggagg aatggagaaa aaggtaggtg 660 ggtgagttgg gggaagagat agggttctct ttttagtgaa agtgacatac tctaaggtca 720 aaagttgcat tcttctcaaa gggcaattca gaccttcatc actccctagt gagggcgcgg 780 agctagatat gcaaagggtt tatataaatt tatgtgatac atttctttta gttaatctaa 840 aaaaagaata aaagtctttt ttttaccaag atcgatttga aatcacacaa atatttgtga 900 atttagatca taaatttcga aagtctttta ataaaaggct aacttctgtt cttggccttt 960 tagaggttag gtacatgctc catcccctcc tttcttgttg ttactatttg ccatggccgg 1020 tagggatcag ggtcaaaccc caatgtatca caggtcaata tagtccgacc gtgacaattt 1080 tctaggggga ttgtgtagaa tcaaatatct attcataaat tgagacattg agacgaatat 1140 tcttctttac attattgaga cgaagaaaat attaaatttt cttaataaaa atcttagctc 1200 ctcactattt ggtctaggtt tcatattcaa tgaattgctg gggtatatgt tattactcaa 1260 ctgaaataaa aagagaattg tcgttatcca ggttagacaa aagcacgtgt agtttcaaac 1320 gcagtagcca ttattctcct ctcctttaca ggtgagattc aagggcagaa aggtaccatg 1380 caagctgtta tttaaattta cttattgatt atgatcgacg actgtgacag aaaaatgatg 1440 atgctttaat tttacgacct agcctttctt tttaagaaga ataaaaaaca tacctcaatt 1500 tggtataaac caatagtttc gtcaatctta aaaacattat tttatttgac tcactaaatt 1560 tagatatatc ttcaatctgc cacataacat aacaaatgat ttcaaactct tgtcggaaca 1620 tatgactctt tataaaaggt ggagaagggt tgaaaacttt actaaatcta acaagatctt 1680 aggtgtgtat ttgactcatg ttgcaagatt gaagtgtatt taaattcagt tagtcaagta 1740 aagaaatatt tttaaagttg tcaatatata attcggagat aaaataataa ttcacactgg 1800 atttagaggg tgttttcgat tcttttcttt tgtttcattt gttgagttta aaattaagtt 1860 gatatgaaac aacaaataaa ttgtgatccc aagttttata tgagcaaaat aaaatcaagc 1920 attgtatatc tctcttttat ttttctctct agtgtccgca ttggagctag actatattcg 1980 aatcgcacta taggcttcat ttttttcata cttgaggctt aaatctgaaa cctctgggta 2040 agggtagaat tatcttgtat ctctttcttt tctttctttg gattttccat ccagcgtttg 2100 gtacccacat tgaagtttag ttaattcaaa tctgcaccac ataggctaag cggttcctac 2160 caatgatctt tccataccta gggactaaaa cacaagacgt ttaattaaga aataaatagt 2220 cccatccact ataccacatc agttgatagt gtggtatatc tcattaagat accacattat 2280 atctatttaa gggggtaggg gggacgggtc tagctagggt tgtggaaatg aggttagaga 2340 gagagtggtt tttcagtgtg tgtgtcaggt gatatcacgt gaaggggcac gataacaagt 2400 tgttcatatc cattcacttc caagaatacc gctacgtaca gtcactagct gctttcttcc 2460 tatccccatc tttgtcaaat ttcctttcct tttccaatta ctttttcttt aatagacatg 2520 gacgcaattc atccttcctt tccccttccc ctatattctt cctttatctc tctttcacaa 2580 taatagcacc atgcctgtag cttgatgctt agacgggtgc acacgcactc tcactcacac 2640 agctagaata tatatatata tatatatata tatatatagt tagcagaagt acttatcata 2700 taccaaaaac cacacaaata cattgtatca agtgctgtca tactcaagca aaagaaagaa 2760 aagaacaaga tatagtacta ctgttttcat caccattttg gtcaatcatg atgattctga 2820 acaaagatat agttactagc taggtagaaa ataaatctac taactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcggcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 109 <211> 3000 <212> DNA <213> Artificial Sequence <400> 109 tagcacaaga tttttaggtt gccgatgcag agaatttaaa tattaatgtt gtgaattcca 60 atactccacc cgttttaaaa aatggtctag tttgactaga aacggagttt aagaaaaaaa 120 aagaccttct acttgtggtt tcaaattaaa gttatgtcaa atgtaccaaa atgtccttta 180 atcttgtggt cctaaacata tcacgtgaaa agttgaagct aaagtgttgc aaaaaaagaa 240 agggattatt cattttgaca caaacaaaaa agaaaactaa ttcattcttt ttgaaacgga 300 ggaatcatac tatatttata tatttggttc tcacaaacct gcaaataagg gcggatgcac 360 aacagaagtt acgagtttga ttaaatctac taattttagt ttgagctttg tatatatgtg 420 tagaggagtc ataaagttca aatattgaat ttactaattt tatcaaagtt gtgatctact 480 gctaattaaa gttgggtggg caggtgggga tgcccggtat tggggaatgt agtatactgt 540 acatctaaaa gcaattttgg caaaaccatc tctgtcactg atctctcact tcacaatact 600 aacatataga gctggggcca aagtagtcat gtagttgatg ggaagagata gtacggagga 660 atggagaaaa aggtaggtgg gtgagttggg gaagagatag ggttctcttt ttagtgaaag 720 tgacatgctc taaggtcaaa agttgcattc ttctcaaagg gcaattcaga ctttcatcac 780 tccctagtga gggcgaggag ctagatatgc aaagggttta tataaattta tgtgatacat 840 ttttttttag ttaatctaaa aaaaaagaat aaaagttttt tttttacacc aagatcgatt 900 tgaaatcaca caaatatttg tgaatttaga tcatgaattt caaaagtctt ttaataaaag 960 gctagcttct gttcttagcc ttttagaggt taggtacatg ctccatcccc tcctttcttg 1020 ttgttactat ttgccatggc cgatagggat caaggtcaaa ccccaatgca tcatagcagt 1080 atagttcgac cgtgacaatt ttctatgggg gattgtgtag aatcaaatat ctattcataa 1140 tttgagacat tgagacgaat attcttcttt acattattga gacaaaaaaa atattaaatt 1200 ttcttaataa aaatcttagc tccccactat ttagtctagg tttcatattc aatgaattgc 1260 tggggtttat gttattactc aactgaaata aaaagagaat tgtcgttatc caggttagac 1320 aaaagcacgt gtagtttcaa acgcagtagc aattattctc ctctccttta caggtgagat 1380 tcaagggcag aaaggtacca tgcaagctgt tatttaaatt tacttattga ttatgatcga 1440 cgactttgac agaaaaatga tgatgcttta attttacgac ctagcctttc tttttaagaa 1500 gaataaaaaa catacctcaa tttggtataa accaatagtt tcgtcaatct aaaaaatatt 1560 cttttacttg actcactaaa tttagatata ttgccacata acataacaaa ttgtttcaaa 1620 cttttgtcgg aacatatgac tcttaataaa aggtggagaa gggttgaaaa ctttactaaa 1680 tttaacaaga tcttatgtgt atatttgact catgttgcaa gattgaagta tatttaaatt 1740 tagttagtca aggtattttt aaggttgtca atatataatt cgaagataaa attaataatt 1800 cacactgaat ttagggagtg ttttcaatac ttttcttttg tttcatttct tgagtttaaa 1860 attaagttga tatgaaacaa caaataaatt gtgatcccaa gttttatatg agcaaaataa 1920 aatcaagcat tgtatatctc tcttttattt ttctccctag tgtccgcatt ggagcccgac 1980 tatattcgaa tcgaactata ggcttcattt ttttcatact cagggcttaa atctaaaacc 2040 tgtgggtaag ggtagaatat cttatatctc tttttttttt tttttctttt ttccatccaa 2100 catttgttac ccacattgaa gttcaattaa ttcaaatttg cgccgcatag gctaagcggt 2160 tcctaccaat gatctttcca tacccaggga ctcaaacgca aaacatttat ttaagaaata 2220 aatagtctca ttcgctatac cacatcagtt gatagtgtga tatatctcat taagatacca 2280 cattatatct atttaagggg gtagggggga cgggtctagc tagggttgtg gaaatgaggt 2340 tagagagagg gtggtttttc agtgtgtgtg tcaggtgaaa tcacgtgaag gggcacgata 2400 acaagttgtt catatccatt cacttccaag aataccgcta cgtacagtca ctagctgctt 2460 tcttcctatc cccatctttg tcaaatttcc tttccttttc caattacttt ttctttaata 2520 gacatggacg caattcttcc ttcctttccc cttcccctat attcttcctt tatctctctt 2580 tcacaataat agcaccatgc ctgtagcttg atgcttagac gggtgcacac gcactctcac 2640 tcacacagct agaatatata tatgaatata tatattcata gttagcagaa gtacttatca 2700 tataccaaaa accatacaaa tacattgtat caagtgctgt catactcaag caaaagaaag 2760 aaaagaacaa gatatagtac tactgttttc atcaccattt tggtcaatca tgatgattct 2820 gaacaaagat atagtactag ctaggtagaa aataaatcta ctaactttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagtagcaa aatcaaaaga ggttttagct gtgtttatac 2940 ggtctttctc aagatctaga cccaccactt agaccatctc aagctacagc taccgcgcaa 3000 <210> 110 <211> 3000 <212> DNA <213> Artificial Sequence <400> 110 gtggttctaa attaaagttg tgtcaaatgt atcaaaatgc cctttaattt tgtggtccta 60 aacatgtcac atgaaaagtt gaagctaaag tgttgtcaaa aaaagaaaag ggtcattctt 120 tcttaaacaa acaaaaaaag aaactaagtc attcttttta aaacgaaggg agtatactat 180 atttatatat ttggttctca caaacctgca aataagggcg gatgcacaat agaagttatg 240 agtttgatta aatctactaa ttttagttta aactttgtat atatgtgtag aggagtcata 300 aagttcaaat actaaattta ctaattttat gaaagttgtg atctactgct aattaaagtt 360 gggtgggcat gtgaggatgc ctggtattgg ggaatatagt atactgtaca tgtaaaagca 420 attgaggcag aaccatctct gtcactgatc tctcacttca caatactaac aaatagagtt 480 ggggccaaag tagtcatgta gttgatggga agagatagta cggatgaatg gagaaaaagg 540 taggtgggtg agttggggga agagataggg ttctcttttt agtgaaagtg acattctcta 600 aggtcaaaag ttgaattctt ctcaaagggc aattcagacc ttcatcactc cctagtgagg 660 gcgcggagct agatatgcaa ggggtttata taaatttatg tgatacattt tttttagtta 720 atctaaaaaa agaataattt ttttattttt ttttaccaag attgatttga aatcacacaa 780 atatttataa atttagatca taaatttcaa gtcttttaat aaaaggctag cttctgttct 840 tggcctttta gaggttaggt acatgctcca tcccctcctt ccttgttgtt actatttgcc 900 atggccagta gggatcaagg tcaaacccca atgcatcaca ggtcagtata gtccgaccgg 960 tgacaatttt ataaggggga ttgtgtagaa tcaaacacta caagaaaatt gtgaattaca 1020 tgaaatattt tctagagatt agtatgaaaa tttacagaaa aataagtttt ctacagattt 1080 tcatactaat ccccaagaaa attctcatgt aattcacact ttttttaata gtgaaatata 1140 tattcataaa ttgagacatt gagacgaata ttcttcttta cattattgag acaaagaaaa 1200 tattaaattt attttaaata agaatcttag ctcctcacta tttagtctag gtttcatatt 1260 cattgaattg ctggggttta tgttattact caactgaaat aaaaagagaa ttgtcgttat 1320 ccaggttaga caaaagcacg tgtagtttca aacgcagtag ccattattcc cctctccttt 1380 acaggtgaga ttcaagggca gaaaggtacc atgcaagctg ttatttaaat ttacttattg 1440 attatgatcg acgactttga cagaaaaatg atgatgcttt aattttgcga cctagccttt 1500 ctttttaaga agtataaaaa acatacctca atttggtata aatcaatagt ttcgtcaatc 1560 ttaaaagcat ttttttactt gactcactaa atttaaatat atcttcgata tgccacattt 1620 caaacttatg tcggaatata tgacttttaa taaaaggtgg agaagggttg aaaactttac 1680 taaatttaac aagatcttag gggtgtattt gacatataat gcaagattga agtgtattta 1740 agttcagtta atcaagtaaa ggggtatttt taaggttgtc aatatataat tcgtagatga 1800 aactaataat tcacactgaa tttaggaggt gttttcgtta cttttctttt gtttcatttg 1860 ttgagtttaa aattaagttg atatgaaaca acaaataaat tctgatccca agttttatat 1920 tagcaaaata aaatcaagca ttgtatatct ctcttttatt tttctccctg gtgtccgcat 1980 tggagtccga ctatattcga atctcactat aggctcatt tttcatac tcgtggctta 2040 aatctgaaat ctcttgataa gggtagaata tcttatatat tttcttt tttgaattt 2100 tccatccaac gttgatatt cacattgaag ttcagttgat tcaatttgc gccgcatagg 2160 ctaagcagtt cctactaatg atctttccat acctaggata tcaacggaa aacgtttgtt 2220 taagaaataa atagttcat ccgctatacc acatcacttg atagtgtggt atatctaatt 2280 aagataccac attatacta tttaaggggg tagggggggg gatgggtcta gctaggtttg 2340 tggaaaggg gttagagaga tagtggtttt tcagtgtgtg tgtcaggtga tcacgtga 2400 aggggcacga taacaagttg ttcatatcca ttcactcca agaataccgc tacgtaccac 2460 tggctgcttc cttcctatcc ccatctttgt caatttcct ttccttttcc aattacttt 2520 tctttaatag acatggacgc aattctcct tccttcccc tcccctata ttctttcctt 2580 tatctctct tcacaataat agcaccatgc ctgtagcttg atgcttagac gggtgcacac 2640 accacactctc accacacag ctagaatata tatatattca tagttagcag aagtacttat 2700 catatatacc aaaaaccaca caaatacatt gtatcaagtg ctgtcatact cgagcaaaaa 2760 aaagaaaaga acaagatata gtactactgt tttcatcacc attttggtca atcatgaaca 2820 agatatagta ctagctagct aggtagaaaa taaatctact aactttaatt ttcttcttat 2880 tgcagctagc ttgcttaatt agcagcaaaa tcaaaagagg tttaagctgt gtgtttatac 2940 cgtctttctc aagatctaga cccaccactt agaccatctc aagctacatc tactgcgcaa 3000 <210> 111 <211> 3000 <212> DNA <213> Artificial Sequence <400> 111 tgattcggtg ggaaaatcat gttttatatc acaaattttt taggttgccg atccagagaa 60 tttaaatatt aatgttgtga attctaatac tccacctgtt ttaaaaaatg gtctagtttg 120 acttgaaacg gagtttaaga aaagaaaaaa gactttctaa tcttgtgatt ccaaattaaa 180 gttatatcaa atgtaccaaa atgtccttta atcttgtggt cttaaatatg tcacgtgaaa 240 aattgaagtt aaagtgttgc caaaaaaaga aaggggtcat tctttttgaa acaaactaaa 300 aaagaaaact aagtcattcc ttttgaaacg gaggaagtat actatattta tatatttggt 360 tctcgcaaac ctgcaaataa gggcggatgc acaaaagaag ttacgagttt gattaaatct 420 tctaatttta gtttaaactt tgtatatatg cgtagagaag tcataaagtt caaatactga 480 atttactaat tttatcaaag ttgtgatcta ctgctgatta aagttgggtg ggcaggtggg 540 gatgcccggt attggggaat gtagtatact gtacatctaa aagcaatttt ggcaaaacca 600 tctctgtcac tgatctctca cttcacaata ctaacatata gagttggggc caaagtagtc 660 atgtagttga tgggaagaga tagtacggag gaatggagaa aaaggtaggt gggtgagttg 720 ggggaagaga tagggttctc tttttagtga aagtgacatg ctctaaggtc aaaagttgca 780 ttcttctcaa agggcaattc agactttcat cactccctag tgagggcgcg gagctagata 840 tgcaaagggt ttatataaat ttatgtgata catttttttt agttaatcta aaaaataata 900 aaagcttttt tttttaccaa gatcgatttg aaatcacaca aatatttgtg aatttagatc 960 ataaatttca aaagtctttt aataaaaggc tagcttctgt tcttggcctt ttagaggtta 1020 ggtacatgct ccatcccctc ctttcttgtt gttactattt gccatggccg gtagggatca 1080 gggtcaaacc ccaatgtatc acaggtcagt atagtccgac cgtgacaatt ttctatgggg 1140 gattgtgtag aatcaaatat ctattcataa attgagacat tgagacgaat attcttcttt 1200 acattattga gacgaaaaaa atattaaatt ttcttaataa aaatcttagc tccccactat 1260 ttagtctagg tttcatattc aatgaattgc tggggtttat gttattactc aactgaaata 1320 aaaagagaat tgtcgttatc caggttagac aaaagcacgt gtagtttcaa acgcagtagc 1380 cattattctc ctctccttta caggtgagat tcaagggcag aaaggtacca tgcaagctgt 1440 tatttaaatt tacttattga ttatgatcga cgactttgac agaaaaatga tgatgcttta 1500 attttacgac ctagcctttc tttttaagaa gaataaaaaa catacctcga tttggtataa 1560 atcaatagtt tcgtcaatct taaaaacatt cttttacttg atttattaaa tttagatata 1620 tcttcgatct gccacataac ataacaaatg gtttcaaacg gaacatatga ctcttaataa 1680 aaggtggaga agggttgaaa actttactaa atttaacaag atcttaggtg tgtatttgac 1740 tcatgttgca agattgaagt gtatttaagt tcagttaatc aagtaaatag atatttttaa 1800 ggttgtcaat atataattcg gagataaaac tagccttttg tttcatttgt tgagtttaaa 1860 attaagttga tatgaaacaa caaataaatt gtgatcccaa gttttatatg agcaaaataa 1920 aatcaagcat tgtatatctc tcttttattt ttctccctgg tatccgcatt ggagcccgac 1980 tatattcgaa tcgcactata ggcttcattt ttttcatact cgaggcttaa atctgaaacc 2040 tctgggtaag ggtagaatat cttatatctc tttttttttt tttggatttt ccattcaacg 2100 tttggtaccc acattgaagt tcagttaatt caaatttgca ccgcataggc taagcggttc 2160 ctaccaatga tcttttcata cccaaggact caaacacaag acgtttaatt aagaagtaaa 2220 tagtctcatc cgctatacca cattgtgtgg tgatatatct cattaagata ccacattata 2280 tctatttaag ggggtagggg ggatgggtct agctagggtt gtggaaatga ggttagagag 2340 agagtggttt ttcagtgtgt gtgtcaggtg atatcacgtg aaggggcacg ataacaagtt 2400 gttcatatcc attcacttcc aagaataccg ctacgtacag tcactagctg ctttcttcct 2460 atccccatct ttgtcaaatt tcctttcctt ttccaattac tttttcttta atagacatgg 2520 acgcaattct tccttccttt ccccttcccc tatattcttc ctttatctct ctttcacaat 2580 aatagcacca tgcctgtagc ttgatgctta gacgggtgca cacgcactct ctcactcaca 2640 cagctagaat atatatatat atatatatat atattcatag ttagcagaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac taactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 112 <211> 3000 <212> DNA <213> Artificial Sequence <400> 112 cagagaattt aaatattaat gttgtgaatt ctaatactcc acctgtttta aaaaatggtc 60 tagtttgact tggaacggag tttaagaaaa gaaagaaaac tttctaattt tgtggttcca 120 aattaaagtt atgtcaaatg tacctaaata ccctttaatt ttgtggtctt aaacatgtca 180 cgtgaaaaat tgaagtcaaa gtgttgtcaa aaaaggaaag gagccattct ttttgaaaca 240 aactaaaaaa aaaaactaga tcattttttt ttaaacggag aagtatacta tatttatata 300 tttggttctc gcaaacctgc aaataagggc ggatgcacaa cagaaattac gagtttgatt 360 aaatctacta attttagttt aaactttgta tatatgtgta gaggagtcat aaagttcaaa 420 tactgaattt actgatttta tcaaagttgt gatctactgc taattaaagt tgggtgggca 480 ggtggggatg ccctgtattg gggaatgtag tatactgtac atctaaaagc aattttggca 540 aaaccatctc tgtcactgat ctctcacttc acaatactaa catatagagt tggggccaaa 600 gaagtcatgt agttgatggg aagagatagt acggaggaat ggagaaaaag gtaggtgggt 660 gagttggggg aagagatagg gttctctttt tagtgaaagt gacatgctct aaggtcaaaa 720 gttgcattct tctcaaaggg caattcagac cttcatcact ccctagtgag ggcgcggagt 780 tagatatgca aaggatttat ataaatttat gtgatacatt ttttttagtt aattttaaaa 840 agaaaaaaag attatttttt ttaccaagat caaattgaaa tcacacaaat atttgtgaat 900 ttagatcata aatttcaaaa atcttttaat aaaaggttag cttctgttct tggcctttta 960 gaggttaggt acatgctcca tcccctcctt tcttgttgtt actatttgtc atggccggta 1020 gggatcaagg tcaaacccca atgcatcaca agtcagtata gtccgaccgt gacaattttc 1080 tatgggggat tgtgtagaat caaatatcta ttcataaatt gagacattga gacgaatatt 1140 cttctttaca ttattgagac gaaaaaaata ttaatttttt taaaataaaa atcttagctc 1200 cccactattt agtctaggtt tcatattcaa tgaattgctg gggtttatgt tattactcaa 1260 ctgaaataaa aagagaattg tcgttatcca ggttagacaa aagcacgtgt agtttcaaac 1320 gcagtagcca ttattctcct ctcctttaca ggtgagattc aagggcagaa aggtaccatg 1380 caagctgtta tttaaattta cttattgatt atgatcgacg actttgacag aaaaatgatg 1440 atgctttaat tttgcgacct agcctttctt tttaagaaga ataaaaaaca tacctcgatt 1500 tggtataaat caatagtttc gtccatctta aaaacattct tttacttgag tcactaaatt 1560 tagatatttc tttgatctgc cacataacat aacaaatgat ttcaaacttt tgtcggaaca 1620 tatgactctt aataaaaggt ggagaagggt tgaaaacttt actaaattta acaagatctt 1680 aggtgtgtat ttgactcatg ttgcaagatt gaagtgtatt taagtttagt tagtcaagta 1740 aaacgatatt tttaagattg tcaatatata attcggagat aaaactaata attcacactg 1800 aatttaggga gtgttttcaa tacctttctt ttgtttcatt tcttgagttt aaaattaagt 1860 tgatatgaaa caacaaataa attgtgatcc caagttttat atgagcaaaa taaaatcaag 1920 cattgtatat ctctctttta tttttctccc tggtgtccgc attggagtcc gactatattc 1980 gaatcacact ataggcttca tttttttcat actcaaggct taaatctgaa acctatgggt 2040 aagggtagaa tatcttatat ctcttttttt ttttcttttg gattttccat ccaacgtttg 2100 ttacccacat tgaagttcag ttaattcaaa tttgcgccgc ataggctaag cggttcctac 2160 caatgatctt tccataccca gggactcaaa cgcaaaatat ttatttaaga aataaattgt 2220 ctcatccgct ataccacatc agttgatagt gtggtatatc tcattaagat accacattat 2280 atctatttaa gggggtaggg gggatgggtc tagctagggt tgtggaaatg aggttagaga 2340 gagggtggtt tttcagtgtg tgtgtcaggt gaaatcacgt gaaggggcac gataacaagt 2400 tgttcatatc cattcacttc caagaatacc gctacgtaca gtcactactg ctttcttcct 2460 atccccatct ttgtcaaatt tcctttcctt ttccaattac tttttcttta atagacatgg 2520 acgcaattct tccttccttt ccccttcccc tatattcttc ctttatctct ctttcacaat 2580 aatagcacca tgcctgtagc ttgatgctta gacgggtgca cacgcactct cactcacaca 2640 gctagaatat atatatatat attatatata tattcatagt tagcagaaat acttatcata 2700 taccaaaaac cacacaaata cattgtatca agtgctgtca tactcaagca aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac caactttaat tttcttctta 2880 atgcagctag ctttgcttaa ttagtagcaa aatcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 113 <211> 3000 <212> DNA <213> Artificial Sequence <400> 113 attcggtggg aaaatcatgt tttatagcac aaatttttta ggttgccgat ccagagaatt 60 taaatattaa tgttgtgaat tctaatactc cacctgtttt aaaaaatggt ctagtttgac 120 ttgaaacgga gtttaagaaa agaaaaaaga ctttctaatc ttgtgattcc aaattaaagt 180 tatgtcaaat ataccaaaat gtcctttaat cttgtgctct taaacatgtc acgtgaaaaa 240 ttgaagttaa agtgttgcca aaaaaagaaa ggggtcatta ttttttaaac aaactaaaaa 300 agaaaactaa gtcattcctt ttgaaacgga gaaagtatac tatatttata tatttggttc 360 tcgcaaacct gcaaataagg gcggatgcac aatagaagtt acgagtttga ttaaatctac 420 taattttaat ttaaactttg tatatatgcg tagagaagtc gtaaagttca aatactgaat 480 ttactaattt tatcaaagtt gtgatctact gctgattaaa gttgggtggg caggtgggga 540 tgcccggtat tggggaatgt agtatactgt acatctaaaa gcaattttgg caaaactatc 600 tctgtcactg atctctcact tcacaatact aacatataga gttggggcca aagtagtcat 660 gtagttgatg ggaagagata gtacggagga atggagaaaa aggtaggtgg gtgagttggg 720 ggaagagata gggttctctt tttagtgaaa gtgacatgct ctaaggtcaa aagttgcatt 780 cttctcaaag ggcaattcag actttcatca ctccctagtg agggcgcgga gctagatatg 840 caaagggttt atataaattt atgtgataca ttttttttag ttaatctaaa agggaataat 900 tttttttttt ttaccaagat cgatttgaaa tcacacaaat atttgtgaat ttagatcata 960 aatttcaaaa atcttttaat aaaaggttag cttctgttct tggcctctta gtggttaggt 1020 agatgctcca tcccctcctt tcttgttgtt actatttgcc atggccggta gggatcaagg 1080 tcaaacccca atgcatcaca ggtcagtata atccgaccgt gacaattttc tatgggggat 1140 tgtgtagaat caaatatcta ttcataaatt gagacattga gacgaatatt cttctttaca 1200 ttattgagac gaaaaaaata ttaaattttt ttaataaaaa tcttagctcc ccactattta 1260 gtctaggttt catattcaat gaattgctgg ggtttatgtt attactcaac tgaaataaaa 1320 agagaattgt cgttatccag gttagacaaa agcacgtgta gtttcaaacg cagtagccat 1380 tattctcctc tcctttacag gtgagattca agggcagaaa ggtaccatgc aagctgttat 1440 ttaaatttac ttattgatta tgatcgacga ctttgacaga aaaatgatga tgctttaatt 1500 ttacgaccta gcctttcttt ttaagaagaa taaaaaacat acctcgattt ggtataaatc 1560 aatagtttcg tcaatcttaa aaacattcct ttacttgact tactaaattt agatatatct 1620 tcgatctgcc acataacata acaaatggtt tcaaacagaa catatgactc ttaataaaag 1680 gtggagaagg attgaaaact ttactaaatt taacaagatc ttaggtgtgt atttgactca 1740 tgttgcaaga ttgaagtgta tttaagttca gttaatcaag taaaaagata tttttaaggt 1800 tgtcaatata taattcggag ataaaactag ccttttgttt catttgttga gtttaaaatt 1860 aagttgatat gaaacaacaa ataaattgtg atcccaagtt ttatatgagc aaaataaaat 1920 caagcattgt atatctctct tttatttttc tccttggtat ccgcattgga gcccgactat 1980 attcgaatcg cactataggc ttcatttttt tcatactcga gtcttaaatc tgaaacctct 2040 gggtaagggt agaatatctt atatctcttt tttttttttt ttggattttc cattcaacgt 2100 ttggtaccca cattgaagtt cagttaattc aaatttgcac cgcataggct aagcggttcc 2160 taccaatgat cttttcatac ccagggactc aaacacaaga catttaatta agaagtaaat 2220 agtctcatcc gctataccac attgtgatat atctcattaa gataccacat tatatctatt 2280 taagggggta ggggggatgg gtctagctag ggttgtggaa atgaggttag agagagagtg 2340 gtttttcagt gtgtgtgtca ggtgatatca cgtgaagggg cacgataaca agttgttcat 2400 atccattcac ttccaagaat accgctacgt acagtcacta gctgctttct tcctatcccc 2460 atctttgtca aatttccttt ccttttccaa ttactttttc tttaatagac atggacgcaa 2520 ttcttccttc ctttcccctt cgcctatatt cttcctttat ctctctttca caataatagc 2580 accatgcctg tagcttgatg cttagacggg tgcacacgca ctctctcact cacacagcta 2640 gaatatatat atatatatat atatatatat atattcatag ttagccgaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa ataaatctac taactttaat tttcttctta 2880 ttgcagctag cttgcttaat tagcagcaaa actcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 114 <211> 3000 <212> DNA <213> Artificial Sequence <400> 114 attttttact gatacagatg ggagaaacct ttatttctag tagtgcgtgc tattaggttg 60 ccgatccaga gaatttaaat attaatgttg tgaattctaa cactccctct gtttaaaaaa 120 gaatggtcta gtttgacttg aaactgagtt taacaaaaga aagaaaactt tttaatctta 180 tggttctaaa ttaaaattat gtcaaatgta ccaaaatgtc ctttaatctt gtggtcctaa 240 acatgtcacg tgaaaagttg aagctaaaat gttgccaaaa aaagaaaggg gtcattcttt 300 tttaaacaaa caaaaaagga aactaagtca ttttttttta aacgaaggga atatactata 360 tttatatatt tggttctcgc aatcctgcaa ataagggcgg atgcacaata gaagttacga 420 gtttgattaa atctactaat tttagtttaa actttgtata tatgtgtaga gaagtcataa 480 agttcaaata ttgaatttac agattttatc aaagttgtga tctactgcta attaaagttg 540 ggtgggcagg tgaagatacc cggtattgag gaatattgta tactgtacat ctaaaagcaa 600 tttaggcaaa accatctctg tcactgatct ctcacttcac aatactaaca gatagagttg 660 gggccaaagt agtcatgtag ttgatgggaa gagatagtac ggaggaatgg agaaaaaagg 720 taggtgggtg agttggggga agagataggg ttctcttttt agtgaaagtg acatcctcta 780 aggtcaaaag ttgcattctt ctcaaagggc aattcagacc ttcatcactc cctagtgagg 840 gcgcggagct agatatgcaa ggggtttata tagatttatg tgatacattt tttttaatta 900 atctaaaaaa gaataaaagt tctttttttt accaagatca atttgaaatc acacaaatat 960 ttgtgaattt atattataaa tttcgaaagt cttttaataa aaggctagct tctatttttg 1020 gccttttaca ggttaggtac atgctccatc ccctccttcc ttgttgttac tatttgccat 1080 ggccggtagg gattaaggtc aaaccccaat gcatcacagg tcaatatagc ccgaacggtg 1140 acaattttct agagggggat tgtgtagaat caaatatcta ttcataaatt gagacgaaga 1200 aaatattaaa ttttcttaat aaaaatcttg gctcctcact atttagtcta ggtttcatat 1260 tcattgaatt gctggggttt atgttattac acaactgaaa taaaaagaga attgtcgtta 1320 tccaggttag acaaaagcac gtgtagtttc aaacgcagta gccattattc tcctctcctt 1380 tacaggtgag attcaagggc agaaaggtac catgcaagct gttatttaaa tttacttatt 1440 gattatgatc gacgactttg acagaaaaat gatgatgctt taattttgcg acctagcctt 1500 tctttttaag aagtataaaa aacatacctt aatttggtat aaatcaatag tttcttcaat 1560 cttaaaagta ttcttttact tgactcacta gatatatctt caatctgtca cataacataa 1620 caaatgattt caaacttttg tcgaaacata tgactcttaa taaaaggcgg agaagggttg 1680 aaaactttac taaatttaac aagatcttag gggtgtattt gactcatgtt gcaagattga 1740 agtgtattta agttcaatta atcaaataaa cggataattt taaggttgtc aacatataat 1800 tcggagatga aactaataat tcacactgaa tttagggggt gttttcgata cttttctttt 1860 gtttcatttg ttgagtttaa aattaagttg atatgaaaca acaaataaat tgtgatccca 1920 agttttatat cagcaaaata aaatcaagca ttgtatatct ctcttttatt tttctccctg 1980 gtgtccgcat tggagcccga ctatattcga atcacactat aggcttcatt tttttcatac 2040 taagggctta aatctgaaac ctctagataa gggtagaata tcttatatct ctttcttttt 2100 tctttttttt tggattttcc atccaacgtt tgatacccac cttgaaattc agttaattca 2160 aatttgcgcc ccataggata agtggttcct accaatgatc tttccatacc cagggactca 2220 aatgtctttt aagaaataag tagtctcatc cgctatacca tagcacttgt tagtgtggta 2280 tacctcatta agataccaca ttatatctat ttaagggggt agggggatgg gtctagctag 2340 ggttgtggaa aggaggttag agagagagag aggtttttca gtgtgtgtgt gtcaggtgat 2400 atcacgtgaa gaggcacgat aacaagttgt tcgtatgtat tcacttccaa gaataccgct 2460 acgtaccact agctacttcc ttcctatccg catctttgtc aaatttcctc tccttttcca 2520 attacttttt gttttataga catggacgca tttcttcctt cctttcccct tcccctatat 2580 tcttcttcct ttatctctct ttcacaataa tagcaccatg cctgtagctt gacggtgcac 2640 gcgcactctc actcacacag ctagaatata tatattcata gttagcagaa gtacttatca 2700 tataccaaaa accacacaaa tacattgtat caaatgctgt catactcaag caaaagaaag 2760 aaaagaacaa gatatagtac aactgttttc atcaccattt tggtcaatca tgatgattct 2820 gaacaagata tagtgtacta gctaggtaga aaataaatct actaacttta attttttctt 2880 attgcagcta gcttgcttaa ttagcagcaa aatcaaaaga gggtttaact gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 115 <211> 3000 <212> DNA <213> Artificial Sequence <400> 115 taaattaaag ttgtgtcaaa tgtaccaaaa tgtcttttaa tcttgtggtc ctaaacatgt 60 cacatgaaaa gttgaagcta aagtgttgtc aaaaaaagaa aggagtcatt ctttttgaaa 120 caaaaaaaaa aaagaaacta aatcattatt tttaaaacaa agggaatata ctatatttaa 180 atatttggtt ctcgcaaacc tgcaaataag ggcggatgca caatagaagt tacgagtttg 240 attaaatcta ctaattttag tttaaacttt gtatatatgt gtagagaagt cataaagttc 300 aaatactgaa tttactaatt ttatcaaagt tgtgatctac tgctaattaa agttgggtgg 360 gcaggtgagg atggccggta ttggggaata tagtatactg tacatctaaa agcaatttag 420 gcagaaccat ctctgtcact gatctctcac ttcacaatac taacatatag agttggggcc 480 aaagtagtca tgtagttgat gggaagagat agtacggagg aatggagaaa aaggtaggtg 540 ggggagttgg gggaagagat agggttctct ttttagtgaa agtgacattc tctaaggtca 600 aaagttgcat tcttctcaaa gggcaattca gaccttcatc actccctagt gagggcgcag 660 agctagatat gcaaggagtt tatataaatt tatgtgatac atttttttag ttaatctaaa 720 aaagaataaa agatatttat tttttaccta gattgatttg aaatcacaca aatatttata 780 aatttagatc ataaatttca taagtctttt aataaaaggc tagcttctgt tcttagcctt 840 ttagaggtta ggtacatgct ccatcccctc cttccttgtt gttactattt ggcatggccg 900 gtagggatca aggtcaaacc ccaatgcatc acatgtcagt atagtccgac cggtgacaat 960 tttctagggg ggattgtgta gaatcaaaca ctacaagaaa tgtgtgaatt acatgagaat 1020 ttttctagga ttaatatgaa aatttgcaga aaaataagtt tcctacagat tttcatacta 1080 atccccaaga aaattctcat gttattcaca ctttttttta tagtaaaata tctattcata 1140 aattgagaca ttgagacgaa tattcttctt tacattattg agacaaagaa aatattaaat 1200 tttcttaata agaatcttag ctcctcacta tttagtctag gtttcatatt cattgaattg 1260 ctggggttta tgttattact caactgaaat aaaaagagaa ttgtcgttat ccaggttaga 1320 caaaagcacg tgtagtttca aacgcagtag ccattattcc cctctccttt acaggtgaga 1380 ttcaagggca gaaaggtacc atgcaagctg ttatttaaat ttacttattg attatgatcg 1440 acgactttga cagaaaaatg atgatgcttt aattttgcga cctagacttt ctttttaaca 1500 agtataaaaa acatacctca atttggtata aatcaataat ttcgtcaatc ttaaaagcat 1560 ttttttactt gattcactaa atttaaatat atcttcgata tgccatattt caaactcttg 1620 tcagaacata tgactctaaa taaaaggtgg agaagggttg aaaactttac taaatttaac 1680 aagatcttag gggtgtattt gactcataat gcaagattga agtgtattta agttcagtta 1740 gtcaagtaaa ggggtatttt taagattgtc aatatataat tcggagatga aactaataat 1800 tcacactgaa tttagggggt gttttcgata cttttctttt gtttcatttg ttgtgtttaa 1860 aattaagttg atatgaaaca acaaataaat tgtgatccca agttttatat cagcaaaata 1920 aaatcaagca ttgtatatct ctcttttatt tttctccttg gtgtccgcat tggagcccaa 1980 ctatattcga atcgcactat aggcttcatt tttttcatac tcggggctta aatctgaaac 2040 ctctggataa gggtagaata tcttatatct cttttttttt tttttttttt ttgaattgtc 2100 tatccaacgt ttggtatcca cattgaagtt cagttgattc aaatttgtgc cgcataggct 2160 aagcggttcc taccaatgat ctttccatat ccaggaactc aaacgcaaaa cgtttattta 2220 agaaataaat agttccatcc gctataccac atcacttgat agtgtggtat atctcattaa 2280 gataccacat tatatctatt taagggggta gaggggaggg atgggtctag ctaggtttgt 2340 ggaaaggagg ttagagagag agtggttttt cagtgtgtgt gtcaggtgat atcacgtgaa 2400 ggggcacaat aacaagttgt tcatatccat tcacttccaa gaataccgct acgtaccact 2460 agctgcttcc tccctatccc catctttgtc aaatttcctt tccttttcca attacttttt 2520 ctttaataga catggacgca atttttcctt cctttcccct tcccctatat tcttcttcct 2580 taatctctct ttcccaataa tagcaccatg cctgtagctt gatgcttaga cgggtgcacg 2640 cgcactctca ctcacccata tatatattca tagttagcag aagtacttat catatatacc 2700 aaaaaccaca caaatacatt gtatcaagtg ctgtcatact caagcaaaaa aaaagaaaag 2760 aacaagatat agtactactg ttttcatcac cattttggtc aatcatgatg attctgaaca 2820 agatatagta ctagctagct aggtagaaaa taaatctact aactttaatt ttcttcttat 2880 tgcagctagc ttgcttaatt agtagcaaaa tcaaaagagg ttttagctgt gtgtttatac 2940 cgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgctcaa 3000 <210> 116 <211> 3000 <212> DNA <213> Artificial Sequence <400> 116 aatttaaata ttaatgttgt gaattctaaa tactccacct gttttaaaaa atggtctagt 60 ttgactagga acggagttta agaaaaaaaa aaaattctaa tcttgtggtt ccaaattaaa 120 gttatgtcaa atgtatcaaa atgcccttta atcttgtggt cctaaatatg tcacgtgaaa 180 aattgaaact aaagtgttgc caaaaaaaga aagggatcat tctttttgaa acaaacaaaa 240 aagaaaacta agtcattctt tttgaaacga aaaaaatata ctatatttat atattaggtt 300 ctcgcaaacc tgcaaataag ggcggatgca caacagaagt tacgagtttg attaaatcta 360 ctaattttgg tttaaacttt gtatatatat gtgtagagga gtcataaagt tcaaatactg 420 aatttactaa ttttatcaaa gttgtgatgt gatctactgc taattaaagt tgggtgggca 480 ggtggggatg cccggtattg gggaatgtag tatactgtac atctaaaagc aattttggca 540 aaaccatctc tgtcactgat ctctcacttc acaatactaa catatagagt tggggccaaa 600 gtagtcatgt agttgatggg aagagatagt acggaggaat ggagaaaaag gtaggtgggt 660 gagttggggg aagagatagg gttctctttt tagtgaaagt gacatgctct aaggtcaaaa 720 gttgcattct tctcaaaggg caattcagac tttcatcact ccctagtgag ggtgcggagc 780 tagatatgca aagggtttat ataaatttat gtgatacatt tttttagtta atctaaaaaa 840 gaataaaagc ttcttttttt accaagatcg atttgaaatc acacaaatat tcgtgaattt 900 agatcataaa tttcaaaaaa attttaataa aaggctatct tctgttcttt gccttttaga 960 ggttaggtac atgctccatc ccctcctttc ttgttgttac tatttgccat ggcaggtagg 1020 gatcaaggtc aaaccccaat gtatcacagg tcagtatagt ccgaccgtga caattttcta 1080 ggggggattg tgtagaatca aatatctatt cataaattga gacattgaga cgaatattct 1140 tctttacatt attgagacga aaaaaatatt aatttttctt aataaaaatc ttagctcccc 1200 actatttagt ctaggtttca tattcaatga attgctgggg tttatgttat tactcaactg 1260 aaataaaaag agaattgtcg ttatccaggt tagacaaaag cacgtgtagt ttcaaacgca 1320 gtagccatta ttctcctctc ctttacaggt gagattcaag ggcagaaagg taccatgcaa 1380 gctgttattt aaatttactt attgattatg atcgacgact ttgacagaaa aatgatgatg 1440 ctttaatttt acgacctagc ctttcttttt aagaagaata aaaaacatac ctcgatttgg 1500 tataaatcaa tagtttcgtc aatcttaaaa accttctttt acttgactta ctaaatttag 1560 atatatcttc gatctgccac ataacataac aaatggtttc aaacggaaca tatgactctt 1620 aataaaaggt ggagaagggt tgcaaacttt actaaattta acaagatctt aggtgtgtat 1680 ttgactcatg ttgcaagatt gaagtgtatt taagttcagt taatcaagta aagagatatt 1740 tttaaggttg tcaatatata attcggagat aaaactaata attcacattg aatttagagg 1800 gtgtttttga catttttctt ttgtttcatt tgttgagttt aaaattaagt tgatacgaaa 1860 caacaaataa attgtgatcc caagttttat atgagcaaaa taaaatcaag cattgtatat 1920 ctctctttta tttttctccc tggtatccgc attggagctc gactatattc gaatcgcact 1980 ataggcttca tttttttcat actcgaggct taaatctgaa acctctgggt aagggtagaa 2040 tatcttatat ctctttcttt ttttttggat tttccattca acgtttggta cccacattga 2100 agttcagtta attcaaattt gcaccgcata ggctaagcag ttcctaccaa tgttcttttc 2160 atacccaatg actcaaacac aagacgttta attaagaaat aaatagtctc atccgctata 2220 ccacatcagt tgatagtgtg atatatctca ttaagatacc acattatatc tatttaaggg 2280 gtagggggga tgggtctagc tagggttgtg gaaatgaggt tagagagaga gtggtttttc 2340 agtgtgtgtg tcaggtgata tcacgtgaag gggcacgata acaagttgtt catatccatt 2400 cacttccaag aataccgcta cgtacagtca ctagctgctt tcttcctatc cccatctttg 2460 tcaaatttcc tttccttttc caattacttt ttctttaata gacatggacg catttcttcc 2520 ttcctttccc cttcccctat attcttcctt tatctctctt tcacaataat agcaccatgc 2580 ctgtagcttg atgcttagac gggtgcacac gcactctctc actcacacag ctagaatata 2640 tatacatata tatatatata tatatatata tattcatagt tagcagaagt acttatcata 2700 taccaaaaac cacacaaata cattgtatca agtgctgtca tactcaagca aaagaaagaa 2760 aagaacaaga tatagtacta ctgttttcat caccattttg gtcaatcatg atgattctga 2820 acaaagatgt agtactagct aggtagaaaa taaatctacc aactttaatt ttcttcttat 2880 tgcagctagc ttgcttaatt agtagcaaaa tcaaaagagg ttttagctgt gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 117 <211> 3000 <212> DNA <213> Artificial Sequence <400> 117 gatccagaga atttaaatat taatgttgtg aattctaata ctcccttcgt ttaaaaaaaa 60 tggtctagtt taacttggaa cagagtttaa caaaagaaat aagacttttt aattttgtgg 120 ttctaaatta aagttatgtc aaatgtacca aaatgccctt taatctagtg gtcctaaaca 180 tgtcacgtga aaagttaaag ctaaagtgtt ggcaaaaaaa gaaaggggtc attctttttt 240 aaacaaacaa aaaaggaaat taagtcattt tttttaaacg aatggagtat actatattta 300 tatatttggt tctcgcaatc gtgcaaataa gggcggctgc acaatagaag ttacgagttt 360 gattaaatct actaatttta gtttaaactt tgtatatatg tgtagagaag tcataaagtt 420 caaatagtga atttacaaat tttatcaaag ttgtgatcta ctgctaatta aagttgggtg 480 ggcaggtgag gatggccggt attggggaat attgtatact gtacatctaa aagcaattta 540 ggtaaaacca tctctgtcac tgatctctca cttcacaata ctaacatata gagttggggc 600 caaagtagtc atgtagttga tgggaagaga tagtacggag gaatggagaa aaaggtaggt 660 gggtgagttg ggggaagaga tagggttctc tttttagtga aagtgacatg ctctaaggtc 720 aaaagttgca ttcttctcaa agggcaattc agacctcatc actccctagt gagggcgcgg 780 agctagatat gcaaagggtt tatataaatt tatacgatac atttttttta gttaatctaa 840 aaaagaataa aagttctttt ttttttttac caagatcaat ttgaaatcac acaaatattt 900 gtgaatttag atcataaatt tcaaaagtct tttaataaaa gacaagctta tgttcttagc 960 cttttagagg ttaggtacat gctccatccc ctccttcctt gttgttacta tttgccatgg 1020 ccggtaggga tcaaggtcaa accccaatgc atcacaggtc agtatagccc gatcggtgac 1080 aattttctaa ggggagattg tgtagaatca aatatctatt cataaattga gacgaatatt 1140 cttctttaca ttattgagac gaagaaaata ttaaattttc ttaataaaaa tcttagctcc 1200 tcactattta gtctaggttt catattcatt gaattgctgg gtttatgtta ctactcaact 1260 gaaataaaaa gagaattgtc gttatccagg ttagacaaaa gcacgtgtag tttcaaacgc 1320 agtagccatt attctcctct cctttacagg tgagattcaa gggcagaaag gtaccatgca 1380 agctgttatt taaatttact tattgattat gatcgacgac tgtgacagaa aaatgatgat 1440 gctttaattt tgcgacctag cctttctttt taagaagtat aaaaaacata cctcaatttg 1500 gtataaatca atagtttcgt caatctttaa agcatttttt tacttgactc actaaatata 1560 tctttgatct gtcacataac ataataaatg atttcaaact cttgtcgtaa catatgactc 1620 ttaataaaaa gtggagaagg gttgaaaact ttactaaatc taacaagatc ttagggggtg 1680 catttgactc atattgcaag attgaagtgt attaaagttc agttagtcaa gtaaaggggt 1740 atttttaaga ttatcaacat ataattcgaa gatgaaacta ataattcaca ctgaatttag 1800 ggggtgtttt cgatactttt cttttgattc atttgttgag tttaaaatta agttagatat 1860 gaaacaacaa ataaattgtg atcccaagtt ttatatcagc aaaataaatt caagcattgt 1920 atatctctct tttattttct ctccggtgtc cgtattggag cccgactata ttcgaatcgc 1980 actataggct tcattttttt catacttagg acttaaatct gaaacctctg ggataatggt 2040 agaatatctt atatctcttt cttttttttt ttttttgaat tttccatcca acatttgata 2100 cccaccttga agttcagtta attcaaattt gtgccgcata ggctaagcgg ttcctaccaa 2160 tgatctttcc atacccacgg actcaaacgt cttttaagac ataaatagtc tcatccatta 2220 caccatatca cttgatagtg tggtatatct cattaagatt ccacattata tctatttaag 2280 gggggtaggg gggatggatc tagctagggt tgtggaaagg aggttagaga gagagaggtt 2340 tttcagtgtg tgtgtcaggt gatatcacgt gaagggccac gataacaagt tgttcgtatc 2400 cattcacttc caagaatacc gctacgtacc actagctatt tccttcctat ccctccccat 2460 cttagtcaaa tttcctttcc tttccttttc caattacttt ttctttaata gacatggacg 2520 catttcttcc ttcctttccc cttcccctat attcttcttc ctttatctct ctttcacaat 2580 aatagcacca tgcctgtagc ttgacgggtg cacgcgcact ctcactcaca cagctagaat 2640 atatatacat atatatatat attcatagtt agcagaagta gttatcatat accaaaaacc 2700 acacaaatac attgtatcaa gtgctgtcat actcaagcaa aagaaagaaa agaacaagat 2760 atagtacaac tgttttcatc accattttgg tcaatcatga tgattctgaa caagatatag 2820 tgtactagct aggtagtaaa taaatctact aactttaatt ttcttcttat tgcagctagc 2880 ttgctcgctt aattagcagc aaaatcaaaa gaggttttag ctgtgtttat actgtatttt 2940 tctcaagatc tagacccacc acttagacca tctcaagcta cagctacagc tactgcgcaa 3000 <210> 118 <211> 3000 <212> DNA <213> Artificial Sequence <400> 118 cctccgtccc attttatgtg gcaccatttt ctttttggtc agtcccaaaa agaatgtcac 60 atttccttat atgataagta tttaaaggta caattcctct tttatccctg ttggtctcac 120 ttaatattaa agatagtact ccaatatatt tatgaggaga gagaaaaatg aatttacttt 180 ttaaaaggca atttgataaa catttcaaag tctttattta tttattaaat tccgtacccg 240 atcaaatatt gccacataaa atgggatgga gggagtactg aatttactaa ttttatcaaa 300 gttgtgatct actgctaatt aaagttgggt gggcaggtga ggatgcctgg tattggagaa 360 tatatagtat actgtacatc taaaagcaat tgaggcaaaa ccatctctgt cactgatctc 420 tcacttcaca atactaacat atagagttgg ggccaaactg ccaaagtagt catgtagttg 480 atgggaagag atagtacgga tgaatggaga aaaaggtagg tgggtgagtt gggggaagag 540 atagggttct ctttttagtg aaagtgacat gctctaaggt caaaagttgc attcttctca 600 aagggcaatt cagaccttca tcactcccta gtgagggcgc ggagctagat atgcaaaggg 660 tttatataaa tttatgtgat acattttttt tagttaattt taaaaaaaat aaaagttttt 720 tttttttttt accaagattg atttgaaatc acacaaatat ttataaattt agatcataaa 780 tttcaaaagt cttttattaa taaaaggcta gcttctgttc ttggcctttt agaggttagg 840 tacatgctcc atcccctctt tccttgttgt tactatttgc catggccggt agggatcaag 900 gtcaaatccc aatgaatcac atgtcagtat agtccgaccg gtgacagttt tctaagtggg 960 attgtgtaga atcaaacgct accaagaaaa gtgtgaatta catgagaatt tttctaggaa 1020 ttagtatgaa aatttgcaaa aaaataagtt tcatacagat ttttatacta atcccaagaa 1080 aattttcatg taattcacac ttttttttat agtgaaatat ctattcataa attgagacat 1140 tgagacgaat attcttcttt acattattga gacgaagaaa atattaattt ttttttaata 1200 agaatcttag ctcctcacta tttagtctag gtttcatatt cattgaattg ctggggttta 1260 tgctattact caactgaaat aaaaagagaa ttgtcgttat ccaggttaga caaaagcacg 1320 tgtagtttca aaacgcagta gccattattc ccctctcctt tacaggtgag attcaagggc 1380 agaaaggtac catgcaagct gttatttaaa tttacttatt gattatgatc gacgactttg 1440 acagaaaaat gatgatgctt taattttgcg acctagcctt tctttttaac aagtataaaa 1500 aacatacctc aatttggtat aaatcaatag tttcatcaat cttaaaaata tttttttact 1560 tgactcacta aatttaaata tatttttgat atgccacatt tcaaactctt gtcggaacat 1620 atgactttta ataaaaggtg gagaagggtt gaaaacttta ctaaatttaa caagatctta 1680 ggggtgtatt tgactcataa tgcaagattg aagtgtattt aagttcagtt aatcaagtaa 1740 aggggtattc ttaagattgt cattatataa ttcggagatg aaactaataa ttcacactga 1800 atttaggggg tgttttcaat acttttcttt tgtttcattt gttgagttta aaattaagtt 1860 gatatgtaaa caaataaatt gtgatcccaa gttttatatc agcaaaataa aatcaagcat 1920 tgtatatctc tcttttattt ttctccctgg tgtccgcatt ggagtccgac tatattcgaa 1980 tctcactata ggcatcattt ttttcatact cagggtttaa atctaaaatc tctggataag 2040 ggtagaatat tttatctctc tttctttttt cttttttttt tttgaatttt gcatccaacg 2100 tttggtatcc acattgaaat tcagttgatt caaatttgcg taacataggc taagcggttc 2160 ctaccaatga tcttttcata cccagaaatt caaacgcaag acgtttgttt aaaaaataaa 2220 tagtaccatc cgctatacca catcacttgg tagtgtgtat atctaattaa gataccacat 2280 tatatctatt taagggggta aggggggatg ggtctagcta gagttgtgga aaggaggtta 2340 gagagagaga gtggtttttc agtgtgtgtg tcaggtgata tcacgtgaag gggcacggta 2400 acaagttgtt catatccatt cacttccaag aataccgcta cgtaccacta gctgcttcct 2460 tcctatcccc atctttgtca aatttccttt ccttttccaa ttactttttc tttaatagac 2520 atggacgcaa ttcttccttc ctttcccctt cccctatatt cttcttcctt tatctctctt 2580 tcacaataat agcaccatgc ctgtagcttg atgctttgac gggtacacac actctcactc 2640 acacagctag aatatatata tatatattca tagttagcag aagtacttat catatatacc 2700 aaaaaccaca caaatacatt gtatcaagtg ctgtcatact caagcaaaaa aaaagaaaag 2760 aacaagatat agtactactg ttttcatcac catttgggtc aatcatgata attctgaaca 2820 agatatagta ctagctagct aggtagaaaa taaatataca tttgtttaat tttcttctta 2880 ttgcagctta gcttgcttaa ttagcagcaa aatcaaaaga ggttttagct gtgtttatac 2940 cgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 119 <211> 3000 <212> DNA <213> Artificial Sequence <400> 119 agaatttaaa tattaatgtt gtgaattcta atactccact tgttttaaaa aatggtctag 60 tttgacttga aacggagttt aagaaaagaa agaaaacttt ctaatcttgt ggttccaaat 120 taaagttatg tcaaatgtac caaaatatcc tttaattttg tagtcttaaa tatgtcacgt 180 gaaaaattga agttaaagtg ttgtcaaaaa aggaaaggaa ccattctttt tgaaacaaac 240 taaaaaaaaa actagatcat ttttttttaa acggagaaag tatactatat ttatatattt 300 ggttctcgca aacctgcaaa taagggcgga tgcacaacag aagttacgag tttgattaaa 360 tctactaatt ttagtttaaa ctttgtatat atgtgtagag gagtcataaa gttcaaatac 420 tgaatttact gattttatca aagttgtgat ctactgctaa ttaaagttgg gtgggcaggt 480 ggggatgccc ggtattgggg aatgtagtat actgtacatc taaaagcaat tttggcaaaa 540 ccatctctgt cactgatctc tcacttcaca atactaacat atagagttgg ggccaaagaa 600 gtcatgtagt tgatgggaag agatagtacg gaggaatgga gaaaaaggta ggtgggtgag 660 ttgggggaag agatagggtt ctctttttag tgaaagtgac atgctctaag gtcaaaagtt 720 gcattcttct caaagggcaa ttcagacctt catcactccc tagtgagggc gcggagctag 780 atatgcaacg agtttatata aatttatgtg atatattttt tttaattaat ctaaaaaaga 840 ataaaaggtt ttttttttta ccaagatcga tttgaaatca cacaaatatt tgtgaattta 9�0 gatcataaat ttcaagtctt ttaataaaaa gctaggttct gttcttggcc ttttagaggt 960 taggtacatg ctccatccac tccttccttg ttgttattat ttgccatgac tggtagggat 1020 caaggtcaaa ccccaatgca tcataggtca gtatagtccg accgtgacga ttttctaggg 1080 gggattgtgt agaataaaat atctattcat aaattgagac attgagacga atattcttct 1140 tcacattatt gagacaaaga aaatattaaa ttttcttaat aaaaatctta gctcctcact 1200 atttagtcta ggtttcatat tcaatgaatt gctgtggggt ttatgttatt actcaactga 1260 aataaaaaga gaattgtcgt tatccaggtt agacaaaagc acgtgtagtt tcaaacgcag 1320 tagccattat tctcctctcc tttacaggtg agattcaagg gcagaaaggt accatgcaag 1380 ctgttattta aatttactta ttgattatga tcgacgactt tgacagaaaa atgatgatgc 1440 tttaattttg cgacctagcc attcttttta agaagaataa aaaacatacc tcgatttggt 1500 ataaatcaat agtttcgtca gtcttaaaag cattctttta cttgagtcac taaatttaga 1560 tatttctttg atctgccaca taacataaca aatgatttca aactcttgtt ggaacatatg 1620 actcttgata aaaggtggag aagggttgaa aactttacta aatttaacaa gatcttaggt 1680 gtgtatttga ctcatgttgc aagattgaag tgtatttaag tttagttagt caagtaaaga 1740 ggtattttta agattgttaa tatataattc ggagataaaa ctaataattc acactgaatt 1800 tagggggtgt tttcaatact tttcttttgt ttcatttctt gagtttaaaa ttaaggtgat 1860 atgaaacaac aaataaattg tgatcccaag ttttaatgaa caaaataaaa tcaagcattg 1920 tatatctctc ttttattttt ctccctggtg tccgcattgg agctcaacta tattcgaatc 1980 acactatagg cttcattttt ttcatactca aggcttaaat ctgaaacctg tgggtaaggg 2040 tagaatatct tatatctctt tttatttttt tttggatttt ccatccaacg tttgttatcc 2100 acattgaagt tcagttaatt caactttgcg ccgcataggc taagtggttc ctaccaatga 2160 tctttccata ccctgggatt caaatacaaa acatttattt aagaaataaa tagtctcatc 2220 cgctatacca tatcagttga tagtgtggta tatctcatta agataccaca ttatatctct 2280 ttaagggggt aggggggatg ggtctagcta gggttgtgga aatgaggtta gagagagggt 2340 ggtttttcag tgtgtgtgtc aggtgaaatc acgtgaaggg gcacgataac aagttgttca 2400 tatccattca cttccaagaa taccgctacg tacagtcact actgctttct tcctatcccc 2460 atctttgtca aatttccttt ccttttccaa ttactttttc tttaatagac atggacgcaa 2520 ttcttccttc ctttcccctt cccctatatt cttcctttat ctctctttca caataatagc 2580 accatgcctg tagcttgatg cttagacggg tgcacacgca ctctcactca cacagctaga 2640 atatatatat ctatatatat atatatattt atattcatag ttagcagaag tacttatcat 2700 ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc aaaagaaaga 2760 aaagaacaag atatagtact actgttttca tcaccatttt ggtcaatcat gatgattctg 2820 aacaaagata tagtactagc taggtagaaa atcaatctac taactttaat tttcttattg 2880 cagctagctt gcttgcttaa ttagcagcaa aatcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgcgcaa 3000 <210> 120 <211> 3000 <212> DNA <213> Artificial Sequence <400> 120 gtagtgcgtg ctgttaggtt gccgatccag agaatttaaa tattaatgtt gtgaattcta 60 atactctctc cgttaaaaaa aaaatgatct agtttgactt ggaacgaaat ttaacaaaag 120 aaaaaagact ttaattttgt ggttttaaat taaagttatg tcaaatgtac caaaatattc 180 tttaatcttg tggttctaaa catgtcacgt gaaaagttga agctaaagtg ttgccaaaaa 240 aagaaaagga tcattctttt tgaaacaaac aaaaaaggaa attaagtcat tctttttaaa 300 acggggggag tatactatat ttatatattt ggttctcgca aacctgcaaa taagggcgga 360 tgcacaatag aaattgcgag tttgattaaa tctactaatt ttagtttaaa ctttgtatat 420 atgcgtagag aagtcataaa gtgcaaatac tgagtttact aattttatca aagttgtgat 480 ctactgctaa ttaaagttgg gtgggcaggt ggggatgccc cgtattgggg aatgtagtat 540 actgtacatc taaaagcaat tttggcaaaa ccatctctgt cactgatctc tcacttcaca 600 atactaacat atagagttgg ggccaaagta gtcatgtagc tgatgggaag agatagtacg 660 gaggaatgga gaaaaaaggt aggtgggtga gttgggggaa gagatagggt tctcttttta 720 gtgaaagtga catgctctaa ggtcaaaagt tgcattcttc tcaaagggca attcagacct 780 tcatcactcc ctagtgaggg ggcggagcta gatatgcaaa gggtttatat aaatttatgt 840 gatacattgt ttttagttaa tttaaaaaag aataaaagtt ttttttttac caagatcgat 900 ttgaaatcac acaaatattt gtgaatttag atcataaatt tcaaaagtct tttaataaaa 960 tgctagcttc tgttcttggc cttttagagg ttaggtacat gctccatccc ctcctttctt 1020 gttgttacta tttgctatgg ccggtaggga tcaaggtcaa atcccaatgt atcacaggtc 1080 agtatagtcc gaccgtgaca attttctagg ggggattgtg tagaatcaaa tatctattca 1140 taaattgaga cattgagacg aatattcttc tttacattat tgagacgaaa aaaatattaa 1200 attttcttaa taaaaatctt agctcctcac tatttagtct aggtttcata ttcaatgaat 1260 tgctggggtt atgttgttac tcaactgaaa taaaaagaga attgtcgtta tccaggttag 1320 acaaaagcac gtgtagtttc aaacgcagta gccattattc tcctctcctt tacaggtgag 1380 attcaagggc agaaaggtac catgcaagct gttatttaaa tttacttatt gattatgata 1440 gacgactttg acagaaaaat gatgatgctt taattttgcg acctagccat tctttttaag 1500 aagaataaaa aacatacctc aatttggtat aaatcaatag ttttgtcaat tttaaaaaca 1560 ttcttttact tgactcacta aatttagata tatcttcgat ctgccacata atataacaaa 1620 taatttcaaa ctcttgtcgg aacatatgac ttttaataaa aggtggagaa gggttgaaaa 1680 ctttactaaa tttaacaaga tcttaggtgt gtatttgact catgttgcaa gattgaagtg 1740 tatttaagtt cagttagtta agtaaagatg tatttttaag gttgtcaata tataattcgg 1800 agataaaact aataattcac actgaattta gggggtattt tcgatacttt tcttttgttt 1860 catttgttga gtttaaaatt aagttgatat gaaacaacaa ataaattgtg atcccaagtt 1920 ttatatcagc aaaataaaat cagtcattgt atatctctct tttatttttc tccttggtgt 1980 ccgcattgga gcccgactgt attcgaatcg tactataggc ttcatttttt gcatactcag 2040 ggcttaaatt tgaaacctct gggtaagggt agaatatcct atatctcttt ctttcttctt 2100 tttttttttg aattttccat ccaacgtttg gtacccacat tgaagtttag ttaattcaaa 2160 tttgcgccgc ataggctaag cggctcctac caatgatctt tccataccca gggactcaaa 2220 cgcaaaacat ttatttaaga aataaataat cccatccgct gtaccacatc agttgatagt 2280 gtggtatatc tcattaagat accacattat atctatttaa gggggtaggg gggatgggtc 2340 tagctagggt tgtggaaatg aggttagaga gagggtggtt tttcagtgtg tgtgtcaggt 2400 gaaatcacgt gaaggggcac gacaacaagt tgttcatatc cattcacttc caagaatacc 2460 gctacgtacc actagctgct ttcttcttat ccccatcttt gtcaaatttc ctttcctttt 2520 ccaattactt tttctttaat agacatggac gcaattcttc cttcctttcc ccttccccta 2580 tattcttcct ttatctctct ttcacaataa tagcaccatg cctgtagctt gatgcttaga 2640 cgggtgcaca cgcactctca ctcacacagc tagaatatat atattcatag ttagcagaag 2700 tacttatcat ataccaaaaa ccacacaaat acattgtatc aagtgctgtc atactcaagc 2760 aaaagaaaaa gatatagtac tactgttttc atcaccattt tggtcaatca tgatgattct 2820 gaacaaagat atagtactag ctaggtagaa aataaatcta ctaactttaa ttttcttctt 2880 attgcagcta gcttgcttaa ttagtagcaa aatcaaaaga ggttttagct gtgtttatac 2940 tgtctttctc aagatctaga cccaccactt agaccatctc aagctacagc tactgggcaa 3000 <210> 121 <211> 3000 <212> DNA <213> Artificial Sequence <400> 121 ccagagaatt taaatattaa tgttgtgaat tctaatactc cacctgtttt aaaaaatggt 60 ctagtttgat ttggaacgga gtttaagaat agaaagaaga ctttctaatc ttgtggttcc 120 aaattaaagt tatgtcaaat gtaccaaaat accctttaat cttgtggtct taaacatgcc 180 acgtgaaaaa ttgaagttaa agtgttgcca aaaaaggaaa ggagccattc tttttgaaac 240 aaactaaaaa agaaactaga tcatattttt ttaaacggag aaagtatact gtatttatat 300 atttggttct tgcagacctg caaataaggg cggatgcaca acagaagtta cgagtttgat 360 taaatctact aattttagtt taaactttgt atatatgtgt agaggagtca taaagtgaat 420 ttactaattt tattaaagtt gtgatctact gctaattaaa gttgggtggg caggtgggga 480 tgcccggtat tggggaatgt agtatactgt acatctaaaa gcaattttgg caaaaccatc 540 tctgtcactg atctctcact tcacaatact aacatataga gttggggcca aagtagtcat 600 gtagttgatg ggaagagata gtacggagga atggagaaaa aggtaggtgg gtgagttggg 660 ggaagagata gggttctctt tttagtgaaa gtgacatgct ctaaggtcaa aagttgcatt 720 cttctcaaag ggcaattcag accttcatca ctctctagtg agggtgcgga gctagatatg 780 caaggagttt atataaattt atgtgatata ttttttttaa ttaatctaaa aaagaataaa 840 agtttttttt ttttaccaag atcgatttga aatcacacaa atatttgtga atttagatca 900 taaatttcaa aagtctttta ataaaaagct aggttctgtt cttggccttt tagaggttag 960 gtacatgctc catccactcc ttccttgttg ttattattta ccatgactgg tagggatcaa 1020 ggtcaaaccc caatgcatca caggtcagta tagtccgacc gtaacgattt tctagggggg 1080 attgtgtaga atcaaatatc tattcataaa ttgagacatt aagacgaata ttcttcttca 1140 cattattgag acaaagaaaa tattaaattt tcttaataaa aatcttagct cctcactatt 1200 tagtctaggt ttcatattca atgaattgct gtggggttta tgttattact caactgaaat 1260 aaaaagagaa ttgtcgttat ccaggttaga caaaagcacg tgtagtttca aacgcagtag 1320 ccattattct cctctccttt acaggtgaga ttcaagggca gaaaggtacc atgcaagctg 1380 ttatttaaat ttacttattg attatgatcg acgactttga cagaaaaatg atgatgcttt 1440 aattttgcga cctagccatt ctttttaaga agaataaaaa acatacctcg atttggtata 1500 aatcaatagt ttcgtcaatc ttaaaagcat tctttaactt gagtcactaa atttagatat 1560 ttctttaatc tgccacataa cataataaat gatttcaaac tcttgtcgga acatatgatt 1620 cttaataaaa ggtggagaag ggttgaaaac tttactaaat ttaacaagat cttaggtgtg 1680 tatttgactc atgttgcaag attgaagtgt atttaagttt aattagtcaa gtaaagaggc 1740 atttttaagg ttgttaatat ataattcgga gataaaacta ataattcaca ctgaatttaa 1800 ggagtgtttt caatactttt cctttgtttc atttcttgag ttcaaaatta agttgatatg 1860 aagcaacaaa taaattgtga tcccaagttt tatatgagca aaataaaatc aagcattgtg 1920 tatctctctt ttatttttct ccctggtgtc tgcattggag ctcaactata ttcgaatcgc 1980 actataggct tcattttttt catactctgg ggcttaaatc ttaaacctgt gggtaagggt 2040 agaatatcta atatctcttt ctcttttttt tttttggatt tttcatccaa tgtttgttac 2100 ccacattgaa gtttagttaa ttcaaatttg cgccgcatag gctaagtggt tcctaccaat 2160 gatcttccca tacccaggga ctcaaacgca aaacatttat ttaaaaaata aatagtctca 2220 tccgctatac cacgtcagtt gatgtggtat atctcattaa gataccacat tatatctatt 2280 taagggggta ggggggatgg gtctaactag ggttgtggaa atgaggttag agagagggtg 2340 gtttttcagt gtgtgtgtca ggtgaaatca cgtgaagggg cacgataaca agttgttcat 2400 atccattcac ttccaagaat accgctacgt acagtcacta gctgctttct tcttatcccc 2460 atctttgtca aatttccttt ccttttccaa ttactttttc tttaatagac atggacgcaa 2520 ttcttccttc ctttcccctt cccctatatt cttcctttat ctctctttca caataatagc 2580 accatgcctg tagcttgatg cttagacggg tgcacacgca ctctcactca cacagctaga 2640 atatatatat ataatatata tatattcata gttagcagaa atacttatca tataccaaaa 2700 accacacaaa tacattgtat caagtgctgt catactcgag caaaagaaag aaaagaacaa 2760 gatatagtac tactgttttc atcaccattt tggtcaatca tgatgattct gaacaaagat 2820 atagtactag ctaggtagaa aataaatcta ctaactttaa ttttcttctt attgcagcta 2880 gcttgcttgc ttaattagca gcaaaatcaa aagaggtttt agctgtgttt atactgtctt 2940 tctcaagatc tagacccacc acttagacca tctcaagcta cagctactgc tactgcgcaa 3000 <210> 122 <211> 3000 <212> DNA <213> Artificial Sequence <400> 122 gttgccgatc cagagaattt aaatattaat gttgtgaatt ctaatactcc acctgtttta 60 aaaaatggtc tagtttgact tggaatagag ttaaagaaaa gaaagaagac tttctaattt 120 tgtggtttct aattaaagtt atgtcaaatg taccaaaata ccctttaatt ttgtggtctt 180 aaacatgtca cgtgacaaat taaagttaaa atgttgccaa aaaaaaaaaa aggagccatt 240 ccttttgaaa caaactaaaa aagaaactag gtcatttttt tttaaacaga gaaagtatac 300 tatatttata tatttgattc tcgcaaacct gcaaataagg gcggatgcac aacagaagtt 360 acgagtttga ttaaatctac taattttagt ttaaactttg tatatttgtg tagaggagtc 420 ataaagttca aatactgaat ttactaattt tatcaaagtt gtaaatctac tgctaattaa 480 agttgggtgg gcaggtgggg atgccctgta ttggggaatg tagtatactg tacatctaaa 540 agcaattttg gcaaaaccat ctctgtcact gatctctcac ttcacaatac taacatatag 600 agttggggcc aaagtagtca tgtagttgat gggaagagat agtacggagg aatggagaaa 660 aaggtaggtg ggtgagttgg gggaagagat agggttctct ttttagtgaa agtgacatg...

Claims

1. Use of a polynucleotide in positively regulating potato tuber development, characterized in that, The polynucleotide comprises at least one of the following nucleotide sequences: 1) The nucleotide sequence shown in SEQ ID NO:1; 2) The nucleotide sequences shown in SEQ ID NO:10 to SEQ ID NO:39; 3) The nucleotide sequence shown in SEQ ID NO:3; 4) The nucleotide sequences shown in SEQ ID NO:66 to SEQ ID NO:96; The positive regulation of potato tuber development includes regulating one or more of tuber formation, advancing the tuber formation time, increasing the number of tubers, and increasing the size of tubers.

2. The application according to claim 1, wherein The polynucleotide further comprises a promoter operably linked to the nucleotide sequence of claim 1, wherein the promoter initiates transcription of the nucleotide sequence in potato cells.

3. The application according to claim 2, wherein Initiate transcription of the nucleotide sequence in stolons.

4. The application according to claim 2, wherein The promoter comprises the nucleotide sequence shown in SEQ ID NO:9, or the polynucleotides shown in SEQ ID NO:97 to SEQ ID NO:

131.

5. Use of a protein in the positive regulation of potato tuber development, characterized in that, The protein is at least one of the following sequences: 1) The protein shown in SEQ ID NO:2; 2) The proteins shown in SEQ ID NO:40 to SEQ ID NO:65; 3) A fusion protein obtained by linking a tag to the N-terminus and / or C-terminus of the proteins shown in 1) and 2) above; The regulation of potato tuber development includes regulating one or more of tuber formation, advancing the tuber formation time, increasing the number of tubers, and increasing the size of tubers.

6. Use of a biomaterial in positively regulating potato tuber development, characterized in that, The biological material is any one of the following 1) to 9): 1) An expression cassette containing the polynucleotide of claim 1; 2) A recombinant vector containing the polynucleotide of claim 1; 3) A recombinant microorganism containing the polynucleotide of claim 1; 4) A plant cell line containing the polynucleotide of claim 1; 9) A plant protoplast, cell or callus into which any one of 1)-3) is introduced; The positive regulation of potato tuber development includes regulating one or more of tuber formation, advancing the tuber formation time, increasing the number of tubers, and increasing the size of tubers.

7. A method for cultivating potatoes, characterized in that, Overexpress the polynucleotide of claim 1 or the protein of claim 5 in a recipient plant to obtain a target plant; compared with the recipient plant, the target plant has an earlier tuber formation time, an increased number of tubers, an increased size of tubers, and / or an increased tuber yield.

8. The cultivation method according to claim 7, characterized in that, The methods for overexpressing the polynucleotide of claim 1 or the protein of claim 5 in the recipient plant include one or more of promoter editing technology, codon optimization, using a strong promoter, inserting an intron, using a viral vector, and fusion protein technology.

9. A method for producing a potato plant and its plant parts, characterized in that, It is one of the following: 1) Growing the plant cell line, plant protoplast, cell or callus described in claim 6 to form a plant; or obtaining a plant by using the cultivation method described in claim 7 or 8; 2) Self-crossing the plant in 1) above to form offspring, and growing the offspring to form a plant and its plant parts; 3) Crossing the plant in 1) above with other varieties to form offspring, and growing the offspring to form a plant and its plant parts.

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