A formula and process for Naoluotong capsules

Through integrated production equipment, the washing, cutting, drying and screening of Chinese medicinal materials in the production of Naoluotong capsules have been integrated, which solves the problems of low efficiency and high cost caused by equipment separation in the existing technology, and improves production efficiency and effect.

CN116785177BActive Publication Date: 2026-03-06DAYA PHARMA HUIZHOU
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-11-29
Publication Date
2026-03-06

AI Technical Summary

Technical Problem

In the current production of Naoluotong capsules, the cleaning and pulverizing processes require different equipment, which affects efficiency and increases costs.

Method used

An integrated production equipment was designed, including a processing tank, a toggle mechanism, a cutting blade, a filter door, a drying chamber, and a screening tank, to achieve integrated processing of medicinal materials for cleaning, cutting, drying, and screening.

Benefits of technology

It improved the efficiency of cleaning and cutting medicinal materials, enhanced the drying effect, reduced equipment costs, simplified the process, and improved overall production efficiency.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention discloses a formula and process for Naoluotong capsules, relating to the field of Naoluotong capsule production technology. To improve the quality of medicinal material processing during production, the equipment includes a processing tank with a lifting chamber at the top and a feeding hopper on one outer wall. A stirring mechanism is installed inside the tank, comprising a stirring main shaft and a stirring rod. A stirring motor is fixed to one outer wall of the tank, the stirring main shaft is rotatably connected to the output end of the stirring motor, and the stirring rod is uniformly fixed to the circumferential outer wall of the stirring main shaft. The formula includes the following components: 10% Ligusticum chuanxiong extract, 10% Salvia miltiorrhiza extract, 10% Astragalus membranaceus extract, 10% tolperidone hydrochloride, 2% methyl hesperidin, and 0.4% vitamin B6. By incorporating a stirring motor, a stirring rod, and an extension rod, this invention enables the stirring motor to drive the stirring rod and extension rod to rotate, thereby agitating the medicinal materials inside the processing tank and improving the cleaning effect.
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Description

Technical Field

[0001] This invention relates to the field of brain-nourishing capsule production technology, and in particular to a brain-nourishing capsule formula and its process. Background Technology

[0002] Naoluotong capsules are a medicine mainly used for cerebral embolism, cerebral thrombosis, and neurological diseases. They have the effect of directly dilating blood vessels, reducing bone tension, and increasing cerebral blood flow. In the production of Naoluotong capsules, the medicinal materials first need to be cleaned and crushed to facilitate further processing. Currently, the cleaning and crushing processes require different equipment, which affects efficiency and the cost of using multiple equipment is high. Therefore, improvements are needed.

[0003] A search revealed Chinese patent application CN201821631774.4, which discloses a medicinal herb cleaning device. The device includes a water tank and a cleaning chamber. A water pipe is located on the right wall of the water tank, and a submersible pump is installed at the connection between the water pipe and the bottom of the water tank. A horizontal pipe is located at the end of the water pipe away from the submersible pump, and the end of the horizontal pipe away from the water pipe is inserted into the cover of the cleaning chamber. A rotary motor is located on the top of the cover, and several cleaning rods are located at the end of the rotary motor away from the top of the cover. The ends of the cleaning rods away from the rotary motor extend into the cleaning tank. An operating layer is located at the end of the cleaning tank away from the cover, and the operating layer includes a reduction motor, a rotating shaft, and a turntable. The cleaning device in the aforementioned patent has the following shortcomings: although it can meet certain cleaning requirements, the subsequent pulverization process requires another device, affecting efficiency. Furthermore, the cost of using multiple devices in combination is high, therefore, further improvement is needed. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a formula for Naoluotong capsules and its production equipment.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A production device for Naoluotong capsules includes a processing tank. A lifting chamber is located at the top of the processing tank, and a feeding hopper is located on one outer wall of the processing tank. A toggle mechanism is installed inside the processing tank, comprising a toggle spindle and a toggle rod. A toggle motor is fixed to one outer wall of the processing tank. The toggle spindle is rotatably connected to the output end of the toggle motor. The toggle rod is evenly fixed to the circumferential outer wall of the toggle spindle. An extension rod extending to one side is provided on one outer wall of the toggle rod. The toggle rod and the extension rod form a Y-shaped structure, with the outer end of the extension rod extending to the toggle spindle. The distance of the main shaft is less than the length of the actuating lever; a lifting motor is installed on the outer wall of the top of the processing tank by screws, the output end of the lifting motor is rotatably connected to a lifting screw, the top end of the lifting screw is rotatably connected to the inner wall of the top of the lifting chamber, a lifting frame is threadedly connected to the outer wall of the lifting screw, a guide rod is fixed to the inner wall of the top of the lifting chamber, the other end of the lifting frame is slidably connected to the outer wall of the guide rod, an installation frame is set at the center of the lifting frame, and equally spaced cutting blades are fixed to the bottom outer wall of the installation frame, the cutting blades and the actuating lever are staggered.

[0007] Preferably, the actuating rod and the extension rod are provided with guide plates, adjacent guide plates form a figure-eight structure, and agitating blades are provided between the actuating rods.

[0008] Furthermore: a first support frame for supporting the treatment tank is fixed at the bottom of the treatment tank; a filter door is hinged to the inner wall of the bottom of the treatment tank; evenly distributed leakage holes are opened on the outer wall of the filter door; a sealing door is hinged to the outer wall of the other side of the filter door; a sealing plug adapted to the leakage holes is adhered to the top outer wall of the sealing door; and a sealing gasket adapted to the shape of the filter door is embedded in the inner wall of the bottom of the treatment tank.

[0009] A further preferred embodiment: multiple conveying slides are installed below the processing tank via a second support frame, the conveying slides are arranged in a symmetrical manner and have an arc-shaped structure, the bottom outer wall of the conveying slides is provided with evenly distributed filter holes, a collection box is provided below the conveying slides, a drying chamber is provided at one end of the conveying slides via a third support frame, a mounting base is fixed on one side inner wall of the drying chamber, and an electric heating rod is installed at one end of the mounting base.

[0010] As a preferred embodiment of the present invention: a flipping motor is fixed to one side of the outer wall of the drying chamber, and a flipping mechanism is provided inside the drying chamber. The flipping mechanism includes a hollow cylinder and an arc-shaped flipping rod. One end of the hollow cylinder is rotatably connected to the output end of the flipping motor via a shaft. The hollow cylinder is sleeved on the outside of the heating rod. The outer circumference of the hollow cylinder has evenly distributed openings. The arc-shaped flipping rod is integrally and equidistantly arranged on the outer circumference of the hollow cylinder, and the arc-shaped flipping rod is distributed in a cyclone-like structure. The size and shape of the arc-shaped flipping rod are adapted to the inner wall of the drying chamber. Equidistantly distributed crossbars are provided between the arc-shaped flipping rods.

[0011] As a preferred embodiment of the present invention: a screening tank is installed above the processing tank via a fourth support frame. The top of the screening tank is provided with a feeding port, and the bottom sides of the screening tank are respectively provided with a medicinal material outlet and an impurity outlet. The impurity outlet is located below the feeding port. The bottom end of the medicinal material outlet is connected to the feeding hopper, and the bottom end of the impurity outlet is fixed with a waste discharge pipe by screws. The side of the screening tank has a circular structure. A screening motor is fixed to one outer wall of the screening tank by screws. The output end of the screening motor is rotatably connected to a screening shaft. The outer circumference of the screening shaft is welded with uniformly distributed screening push plates. The screening push plates have a J-shaped structure, and uniformly distributed screen holes are opened on one outer wall of the screening push plates.

[0012] As a preferred embodiment of the present invention: elastic ropes are connected between the arc-shaped flipping rods and between the crossbars, and a swing ball is provided at the intersection of the elastic ropes.

[0013] A formula for Naoluotong capsules includes the following ingredients: 10% Ligusticum chuanxiong extract, 10% Salvia miltiorrhiza extract, 10% Astragalus membranaceus extract, 10% tolperidone hydrochloride, 2% methyl hesperidin, 0.4% vitamin B6, and the balance being dry starch and magnesium stearate.

[0014] As a further preferred embodiment of the present invention, the preparation process of the Naoluotong capsules includes: ① pretreatment; ② extraction and drying of traditional Chinese medicine; ③ oral solid dosage form.

[0015] Based on the aforementioned scheme, the specific steps of the preprocessing are as follows:

[0016] S11: Take Danshen, Chuanxiong, and Huangqi according to the weight parts;

[0017] S12: Sorting, removing defective products and impurities to obtain raw materials for Chinese medicinal herbs;

[0018] S13: Place the Chinese medicinal materials in the processing tank and add water, then control the motor to clean them.

[0019] S14: After cleaning, open the sealed door, drain the water, and then close it again;

[0020] S15: The cutting blade is extended into the processing tank by controlling the lifting motor, and the actuating motor is controlled to work to cut and crush the material.

[0021] S16: Open the sealed door and filter door to allow the crushed medicinal materials to be transported from the conveyor chute to the drying chamber;

[0022] S17: Controls the operation of the flipping motor and heating rod to perform the drying process;

[0023] S18: Obtain the processed clean medicinal materials and store them temporarily.

[0024] Based on the aforementioned scheme, the preferred steps for the extraction and refining of the traditional Chinese medicine are as follows:

[0025] S21: Take the processed clean medicinal materials according to the specified proportion;

[0026] S22: Add water and decoct three times, two hours each time, then combine the decoctions;

[0027] S23: Extracted by extraction solvent and then filtered;

[0028] S24: Concentrate the filtrate to a thick paste;

[0029] S25: Dry the extract at below 100℃ to obtain a dry extract with a moisture content of no more than 5%, thus obtaining Chuanxiong extract, Danshen extract and Huangqi extract;

[0030] S26: Grind and then sieve.

[0031] A further optimized version of the aforementioned scheme includes the following specific steps for the oral solid dosage form:

[0032] S31: Take the materials obtained in the extraction and drying steps of traditional Chinese medicine;

[0033] S32: Weigh the remaining raw materials according to the proportion and mix them together;

[0034] S33: Sift after drying;

[0035] S34: After inspection, capsules are prepared by filling and polishing.

[0036] S35: Secondary inspection;

[0037] S36: Packaging.

[0038] The beneficial effects of this invention are as follows:

[0039] 1. This invention, by incorporating a toggle motor, a toggle lever, and an extension rod, enables the toggle motor to rotate the toggle lever and extension rod, thereby agitating the medicinal materials within the processing tank and improving the cleaning effect. By including a cutting blade and a lifting frame, the lifting motor can be controlled to operate after cleaning, causing the lifting frame to rise and fall, allowing the cutting blade to extend into the processing tank. As the toggle lever rotates the medicinal materials, they are cut and broken as they pass through the cutting blade. Because the toggle lever and extension rod form a Y-shaped structure, the extension rod can confine large-sized medicinal materials between the toggle lever and extension rod during rotation, ensuring optimal cutting results.

[0040] 2. By setting guide plates, the medicinal materials can come into contact with the cutting blade during cutting and be squeezed between the two guide plates. The guide plates reliably limit and support the medicinal materials, thereby facilitating the cutting blade to complete the cutting and improving cutting efficiency and effect.

[0041] 3. By setting up agitator blades, the water can be agitated as the main shaft rotates, thereby improving the cleaning effect.

[0042] 4. By setting up a filter door and a sealing door, it is possible to open only the sealing door according to the actual situation, so that the sealing plug is removed from the leakage hole, thereby draining the water in the treatment tank. After the water is drained, the filter door is opened to output the medicinal materials in the treatment tank, thus improving functionality and practicality.

[0043] 5. By setting up structures such as conveyor slides and collection boxes, the falling medicinal materials can be caught and transported. Due to the filter holes, any water that has not been drained can be screened into the collection box during the transport process, which improves its practicality.

[0044] 6. By setting up a drying chamber, electric heating rods, and other structures, it is possible to collect the medicinal materials that slide down from the conveyor chute and use the electric heating rods to dry the medicinal materials.

[0045] 7. By setting up a rotating motor and rotating mechanism, the rotating motor drives the hollow cylinder to rotate, and then the arc-shaped rotating rod scoops up the medicinal materials in the drying chamber to prevent the medicinal materials from piling up. As the hollow cylinder continues to rotate, the medicinal materials are continuously scooped up and thrown down by the arc-shaped rotating rod. During this period, the electric heating rod continuously bakes the medicinal materials, thereby ensuring that the medicinal materials are heated evenly and improving the drying effect.

[0046] 8. By setting crossbars, the gaps in the flipping mechanism can be reduced, thereby improving the flipping effect and ensuring the overall stability of the flipping mechanism.

[0047] 9. By setting up a screening tank and screening motor, medicinal materials can be added into the screening tank through the feeding port. The screening motor drives the screening push plate to rotate, pushing the medicinal materials counterclockwise. During this process, impurities in the medicinal materials are screened through the screen holes and fall into the impurity output port, and then discharged from the waste discharge pipe. After being screened, the medicinal materials fall into the medicinal material discharge port after the screening push plate rotates to a certain angle, and then fall from the feeding hopper into the processing tank, thereby improving the processing effect of the medicinal materials.

[0048] 10. By setting up elastic ropes and swing balls, the gap between the arc-shaped flipping rod and the crossbar is reduced, ensuring the flipping effect. At the same time, during flipping, the swing ball can vibrate based on the elasticity of the crossbar, thereby breaking up the medicinal materials in contact with it and improving the drying effect. Attached Figure Description

[0049] Figure 1 This is a schematic diagram of the overall structure of a production equipment for Naoluotong capsules proposed in this invention;

[0050] Figure 2This is a schematic diagram of the other side of the production equipment for Naoluotong capsules proposed in this invention;

[0051] Figure 3 This is a cross-sectional schematic diagram of the processing tank of the production equipment for Naoluotong capsules proposed in this invention;

[0052] Figure 4 This is a schematic diagram of the actuation mechanism of a production equipment for Naoluotong capsules proposed in this invention;

[0053] Figure 5 This is a cross-sectional schematic diagram of the lifting chamber of a production equipment for Naoluotong capsules proposed in this invention;

[0054] Figure 6 This is a schematic diagram of the structure of the filter door and sealing door of the production equipment for Naoluotong capsules proposed in this invention.

[0055] Figure 7 This is a cross-sectional schematic diagram of the drying chamber of a production equipment for Naoluotong capsules proposed in this invention;

[0056] Figure 8 This is a schematic diagram of the overall structure of a production equipment for Naoluotong capsules according to Embodiment 3 of the present invention;

[0057] Figure 9 This is a cross-sectional schematic diagram of the screening tank of a production equipment for Naoluotong capsules according to Embodiment 3 of the present invention;

[0058] Figure 10 This is a schematic diagram of the structure of the flipping mechanism of the production equipment for Naoluotong capsules according to Embodiment 4 of the present invention;

[0059] Figure 11 This is a flowchart of the pretreatment process for the preparation of Naoluotong capsules proposed in this invention;

[0060] Figure 12 This invention provides a flowchart of the traditional Chinese medicine extraction and refining process for preparing Naoluotong capsules.

[0061] Figure 13 This is a flowchart of a process for preparing Naoluotong capsules for oral solid dosage forms, as proposed in this invention.

[0062] Figure 14 This is a comparative evaluation chart of the formulations in Examples 6 and 7 of the present invention for the Naoluotong capsule.

[0063] Figure 15 This is a comparison diagram of the drying effects of the Naoluotong capsule proposed in this invention using the equipment of Example 2 and a conventional drying device;

[0064] Figure 16This is a graph showing the relationship between drying temperature and product quality in S17 of the preparation process of Naoluotong capsules proposed in this invention.

[0065] In the diagram: 1. Processing tank; 2. Actuating motor; 3. First support frame; 4. Conveying chute; 5. Collection box; 6. Tilting motor; 7. Drying chamber; 8. Third support frame; 9. Tilting mechanism; 10. Lifting chamber; 11. Feed hopper; 12. Filter holes; 13. Second support frame; 14. Cutting blade; 15. Actuating rod; 16. Guide plate; 17. Extension rod; 18. Actuating spindle; 19. Sealing gasket; 20. Filter door; 21. Mounting bracket; 22. Agitating blade; 23. Lifting motor; 24. Lifting... 25 Screw, 26 Guide rod, 27 Lifting frame, 28 Sealing plug, 29 Sealing door, 30 Leakage hole, 30 Crossbar, 31 Arc-shaped flipping rod, 32 Hollow cylinder, 33 Heating rod, 34 Mounting base, 35 Through port, 36 Screening tank, 37 Screening motor, 38 Fourth support frame, 39 Herbal material outlet, 40 Waste discharge pipe, 41 Impurity output port, 42 Feeding port, 43 Screen hole, 44 Screening shaft, 45 Screening push plate, 46 Swinging ball, 47 Elastic rope. Detailed Implementation

[0066] The technical solution of this patent will be further described in detail below with reference to specific embodiments.

[0067] The embodiments of this patent are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this patent, and should not be construed as limiting this patent.

[0068] In the description of this patent, it should be understood that the terms “center,” “upper,” “lower,” “front,” “back,” “left,” “right,” “vertical,” “horizontal,” “top,” “bottom,” “inner,” and “outer,” etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this patent and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this patent.

[0069] In the description of this patent, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "setting" should be interpreted broadly. For example, they can refer to a fixed connection or setting, a detachable connection or setting, or an integral connection or setting. Those skilled in the art can understand the specific meaning of the above terms in this patent according to the specific circumstances.

[0070] Example 1:

[0071] A production equipment for Naoluotong capsules, such as Figure 1-7 As shown, the system includes a processing tank 1. A lifting chamber 10 is integrally formed on the top of the processing tank 1. A feeding hopper 11 is integrally formed on one side of the outer wall of the processing tank 1. A toggle mechanism is installed inside the processing tank 1. The toggle mechanism includes a toggle spindle 18 and a toggle rod 15. A toggle motor 2 is fixed to one side of the outer wall of the processing tank 1 by screws. The toggle spindle 18 is rotatably connected to the output end of the toggle motor 2. The toggle rod 15 is evenly welded to the circumferential outer wall of the toggle spindle 18. An integrally formed feeding hopper 11 is provided on one side of the outer wall of the toggle rod 15. An extension rod 17 extending to one side, actuating rod 15, and extension rod 17 form a Y-shaped structure, and the distance from the outer end of extension rod 17 to actuating main shaft 18 is less than the length of actuating rod 15; a lifting motor 23 is screwed onto the top outer wall of the processing tank 1, and a lifting screw 24 is rotatably connected to the output end of the lifting motor 23. The top end of the lifting screw 24 is rotatably connected to the top inner wall of the lifting chamber 10, and a lifting frame 26 is threaded onto the outer wall of the lifting screw 24. The top inner wall of the lifting chamber 10 is fixed with screws. The guide rod 25 and the inner wall of the lifting frame 26 are slidably connected to the outer wall of the guide rod 25. The lifting frame 26 is integrally provided with a mounting frame 21 at the center position. The bottom outer wall of the mounting frame 21 is welded with equally spaced cutting blades 14. The cutting blades 14 and the actuating rod 15 are arranged in an alternating manner. By setting the actuating motor 2, the actuating rod 15 and the extension rod 17, the actuating motor 2 can drive the actuating rod 15 and the extension rod 17 to rotate, thereby driving the medicinal materials in the processing tank 1 to stir and improve the cleaning effect. By setting up structures such as the cutting blade 14 and the lifting frame 26, the lifting motor 23 can be controlled to work after cleaning, driving the lifting frame 26 to rise and fall, so that the cutting blade 14 extends into the processing tank 1. As the actuating rod 15 drives the medicinal materials to rotate, the medicinal materials are cut and crushed when passing through the cutting blade 14. Since the actuating rod 15 and the extension rod 17 form a Y-shaped structure, during rotation, the extension rod 17 can restrict large-sized medicinal materials as much as possible between the actuating rod 15 and the extension rod 17 to ensure the cutting effect.

[0072] To improve the cutting effect; such as Figure 3 , Figure 4 As shown, the actuating rod 15 and the extension rod 17 are integrally provided with guide plates 16, and adjacent guide plates 16 form a figure-eight structure; the position of the cutting blade 14 is adapted to the gap of the figure-eight structure; by setting the guide plates 16, the medicinal material can contact the cutting blade 14 during cutting and be squeezed between the two guide plates 16. The guide plates 16 reliably limit and support the medicinal material, thereby facilitating the cutting blade 14 to complete the cutting and improving the cutting efficiency and cutting effect.

[0073] To improve cleaning effectiveness; such as Figure 4As shown, an agitator blade 22 is integrally provided between the agitator rods 15; by providing the agitator blade 22, the water can be agitated by the rotation of the agitator main shaft 18, thereby improving the cleaning effect.

[0074] To facilitate the drainage of the water after cleaning; such as Figure 3 , Figure 6 As shown, the bottom of the treatment tank 1 is fixed with screws to a first support frame 3 for supporting the treatment tank 1. A filter door 20 is hinged to the inner wall of the bottom of the treatment tank 1. The outer wall of the filter door 20 has evenly distributed leakage holes 29. The outer wall of the other side of the filter door 20 is hinged to a sealing door 28. A sealing plug 27 adapted to the leakage holes 29 is glued to the top outer wall of the sealing door 28. A sealing gasket 19 adapted to the shape of the filter door 20 is embedded in the inner wall of the bottom of the treatment tank 1. When the filter door 20 and the sealing door 28 are opened, they form a V-shaped structure. By setting the filter door 20 and the sealing door 28, it is possible to open only the sealing door 28 according to the actual situation, so that the sealing plug 27 is disengaged from the leakage holes 29, thereby draining the water in the treatment tank 1. After the water is drained, the filter door 20 is opened, thereby outputting the medicinal materials in the treatment tank 1, which improves functionality and practicality.

[0075] To facilitate the transport of pulverized medicinal materials; such as Figure 1 , Figure 2 As shown, multiple conveying slides 4 are installed below the processing tank 1 via a second support frame 13. Each conveying slide 4 is integrally formed and has an arc-shaped structure. The bottom outer wall of the conveying slide 4 is provided with evenly distributed filter holes 12. A collection box 5 is provided below the conveying slide 4. By setting up the conveying slide 4, collection box 5 and other structures, the falling medicinal materials can be received and conveyed. Due to the filter holes 12, the water that has not been drained can be screened into the collection box 5 through the filter holes 12 during the conveying process, which improves the practicality.

[0076] In this embodiment, the user adds the medicinal materials to be processed from the feeding hopper 11 into the processing tank 1, and pours in an appropriate amount of water. The agitator motor 2 drives the agitator rod 15 and extension rod 17 to rotate, thereby agitating the medicinal materials in the processing tank 1. As the agitator shaft 18 rotates, the agitator blades 22 simultaneously agitate the water to improve the cleaning effect. After cleaning, the lifting motor 23 is controlled to operate, driving the lifting frame 26 to rise and fall along the outer wall of the guide rod 25, allowing the cutting blade 14 to extend into the processing tank 1. Because the agitator rod 15 drives the medicinal materials to rotate, the medicinal materials come into contact with the cutting blade 14 as they pass through it. The material is touched and squeezed between two guide plates 16. The guide plates 16 reliably limit and support the material, which facilitates the cutting blade 14 to complete the cutting. Since the actuating rod 15 and the extension rod 17 form a Y-shaped structure, the extension rod 17 can limit the large-sized material between the actuating rod 15 and the extension rod 17 as much as possible during rotation to ensure the cutting effect. During the cleaning and cutting process, the user can open the sealing door 28 only according to the actual situation, so that the sealing plug 27 is disengaged from the leakage hole 29, thereby draining the water in the treatment tank 1. After draining the water, the filter door 20 is opened to output the material in the treatment tank 1.

[0077] In addition, at the end of the cleaning process, the user can open the sealing door 28 to drain some of the water, leaving the other part of the water in the treatment tank 1. When cutting, the buoyancy of the herbs can be used to make the lever 15 more fully and easily move the herbs at the bottom of the treatment tank 1, thus improving reliability.

[0078] Example 2:

[0079] A production equipment for Naoluotong capsules, such as Figure 1 As shown, in order to facilitate the drying of the cleaned medicinal materials, this embodiment makes the following improvements based on embodiment 1: a drying chamber 7 is provided at one end of the conveying slide 4 and fixed by a third support frame 8. A mounting base 34 is fixed to one side of the inner wall of the drying chamber 7 by screws, and an electric heating rod 33 is installed at one end of the mounting base 34. By setting up the drying chamber 7, the electric heating rod 33 and other structures, the medicinal materials sliding down from the conveying slide 4 can be collected, and the medicinal materials can be dried by the operation of the electric heating rod 33.

[0080] To improve the drying effect, such as Figure 7As shown, a rotating motor 6 is fixed to one side of the outer wall of the drying chamber 7 by screws. A rotating mechanism 9 is provided inside the drying chamber 7. The rotating mechanism 9 includes a hollow cylinder 32 and an arc-shaped rotating rod 31. One end of the hollow cylinder 32 is rotatably connected to the output end of the rotating motor 6 via a shaft. The hollow cylinder 32 is sleeved on the outside of the heating rod 33. The outer circumference of the hollow cylinder 32 has evenly distributed openings 35. The arc-shaped rotating rod 31 is integrally and equidistantly arranged on the outer circumference of the hollow cylinder 32. The structure is arranged in a cyclone shape, and the size and shape of the arc-shaped flipping rod 31 are adapted to the inner wall of the drying chamber 7. By setting up structures such as the flipping motor 6 and the flipping mechanism 9, the hollow cylinder 32 can be rotated by the operation of the flipping motor 6, and then the arc-shaped flipping rod 31 can be used to scoop up the medicinal materials in the drying chamber 7 to avoid the accumulation of medicinal materials. As the hollow cylinder 32 continues to rotate, the medicinal materials are continuously scooped up and thrown down by the arc-shaped flipping rod 31. During this period, the electric heating rod 33 continuously bakes the medicinal materials, thereby ensuring that the medicinal materials are heated evenly and improving the drying effect.

[0081] To improve structural strength, such as Figure 7 As shown, the arc-shaped flipping rods 31 are integrally provided with equally spaced crossbars 30; by setting the crossbars 30, the gaps in the flipping mechanism 9 can be reduced, thereby improving the flipping effect and ensuring the overall firmness of the flipping mechanism 9.

[0082] Example 3:

[0083] A production equipment for Naoluotong capsules, such as Figure 8 , Figure 9As shown, to facilitate the removal of impurities from medicinal materials, this embodiment makes the following improvements based on embodiment 2: A screening tank 36 is installed above the processing tank 1 via a fourth support frame 38. The top of the screening tank 36 has a feeding port 42, and the bottom sides of the screening tank 36 have a medicinal material outlet 39 and an impurity outlet 41, respectively. The impurity outlet 41 is located below the feeding port 42. The bottom end of the medicinal material outlet 39 is connected to the feeding hopper 11, and the bottom end of the impurity outlet 41 is fixed with a waste discharge pipe 40 by screws. The screening tank 36 has a circular side structure. A screening motor 37 is fixed to one outer wall of the screening tank 36 by screws. The output end of the screening motor 37 is rotatably connected to a screening shaft 44. The outer wall of the 44 is welded with uniformly distributed screening push plates 45. The screening push plates 45 have a J-shaped structure, and uniformly distributed screen holes 43 are opened on one side of the outer wall of the screening push plates 45. By setting up a screening tank 36 and a screening motor 37, the medicinal materials can be added into the screening tank 36 through the feeding port 42. The screening motor 37 drives the screening push plates 45 to rotate, pushing the medicinal materials in a counterclockwise direction. During this process, impurities in the medicinal materials are screened through the screen holes 43 and fall into the impurity output port 41, and then discharged from the waste discharge pipe 40. After being screened, the medicinal materials fall into the medicinal material discharge port 39 after the screening push plates 45 rotate to a certain angle, and then fall into the processing tank 1 from the feeding hopper 11, thereby improving the processing effect of the medicinal materials.

[0084] Example 4:

[0085] A production equipment for Naoluotong capsules, such as Figure 10 As shown, in order to improve the drying effect of medicinal materials, this embodiment makes the following improvements based on embodiment 3: elastic ropes 47 are connected between the arc-shaped flipping rods 31 and between the crossbars 30, and a swing ball 46 is set at the intersection of the elastic ropes 47; by setting the elastic ropes 47 and the swing ball 46, the gap between the arc-shaped flipping rods 31 and the crossbars 30 is reduced, ensuring the flipping effect. At the same time, during flipping, the swing ball 46 can vibrate based on the elastic force of the crossbars 30, thereby breaking up the medicinal materials in contact with it and improving the drying effect.

[0086] Example 5:

[0087] A formula for Naoluotong capsules includes the following ingredients: 6-12% Ligusticum chuanxiong extract, 6-12% Salvia miltiorrhiza extract, 6-12% Astragalus membranaceus extract, 6-12% tolperidone hydrochloride, 1-3% methyl hesperidin, 0.4% vitamin B6, and the balance being dry starch and magnesium stearate.

[0088] Example 6:

[0089] A formula for Naoluotong capsules, based on Example 5, further specifies the formula to include the following ingredients: 10% Ligusticum chuanxiong extract, 10% Salvia miltiorrhiza extract, 10% Astragalus membranaceus extract, 10% tolperidone hydrochloride, 2% methyl hesperidin, 0.4% vitamin B6, with the balance being dry starch and magnesium stearate.

[0090] Example 7:

[0091] A formula for Naoluotong capsules, based on Example 5, further specifies the formula to include the following ingredients: 8% Ligusticum chuanxiong extract, 8% Salvia miltiorrhiza extract, 8% Astragalus membranaceus extract, 8% tolperidone hydrochloride, 2% methyl hesperidin, 0.4% vitamin B6, with the balance being dry starch and magnesium stearate.

[0092] Example 8:

[0093] The preparation process of the Naoluotong capsules includes: ① pretreatment; ② extraction and drying of traditional Chinese medicine; ③ oral solid dosage form.

[0094] The specific steps of the preprocessing are as follows:

[0095] S11: Take Danshen, Chuanxiong, and Huangqi according to the weight parts;

[0096] S12: Sorting, removing defective products and impurities to obtain raw materials for Chinese medicinal herbs;

[0097] S13: Place the Chinese medicinal materials into the processing tank 1 and add water, then control the motor 2 to work and clean them.

[0098] S14: After cleaning, open the sealed door 28, drain the water, and then close it again;

[0099] S15: The cutting blade 14 is extended into the processing tank 1 by controlling the lifting motor 23, and the actuating motor 2 is controlled to work to cut and crush.

[0100] S16: Open the sealing door 28 and the filter door 20 to allow the crushed medicinal materials to be transported from the conveyor slide 4 to the drying chamber 7;

[0101] S17: Control the operation of the flipping motor 6 and the heating rod 33 to perform the drying process;

[0102] S18: Obtain the processed clean medicinal materials and store them temporarily.

[0103] The drying temperature is controlled between 70 and 95°C, preferably 85°C.

[0104] The specific steps for the extraction and refining of the traditional Chinese medicine are as follows:

[0105] S21: Take the processed clean medicinal materials according to the specified proportion;

[0106] S22: Add water and decoct three times, two hours each time, then combine the decoctions;

[0107] S23: Extracted by extraction solvent and then filtered;

[0108] S24: Concentrate the filtrate to a thick paste;

[0109] S25: Dry the extract at below 100℃ to obtain a dry extract with a moisture content of no more than 5%, thus obtaining Chuanxiong extract, Danshen extract and Huangqi extract;

[0110] S26: Grind and then sieve.

[0111] The specific steps for the oral solid dosage form are as follows:

[0112] S31: Take the materials obtained in the extraction and drying steps of traditional Chinese medicine;

[0113] S32: Weigh the remaining raw materials according to the proportion and mix them together;

[0114] S33: Sift after drying;

[0115] S34: After inspection, capsules are prepared by filling and polishing.

[0116] S35: Secondary inspection;

[0117] S36: Packaging.

[0118] Experiment 1:

[0119] To ensure the efficacy of Naoluotong capsules, and keeping other conditions constant, the formulations of Examples 6 and 7 were used for multiple preparations. The resulting Naoluotong capsules were evaluated, and the following data were obtained:

[0120] Formula Example 6 Example 7 Headache relief effect 89 74 Eliminate dizziness 91 83 Relief of numbness in limbs 84 69 Relieves fatigue and weakness 88 77

[0121] As can be seen from the above, the overall effect of the formulation of Example 6 is better than that of the formulation of Example 7. Therefore, it is preferable to use the formulation of Example 6 for preparation.

[0122] Experiment 2:

[0123] To ensure the drying effect of the Naoluotong capsules, and keeping other conditions unchanged, the production equipment of Example 2 and a conventional drying device were used in the drying step S17 to evaluate the drying effect, and the following data were obtained:

[0124] Equipment used Example 2 ordinary drying equipment Drying uniformity 91 69 Drying efficiency 95 74 Dryness 88 81

[0125] As can be seen from the above, the overall effect of using the equipment in Example 2 for drying is significantly better than that of ordinary drying devices on the market, especially in terms of drying uniformity and drying efficiency.

[0126] Experiment 3:

[0127] To ensure the quality of Naoluotong capsules, while keeping other conditions constant, the drying temperature in step S17 was changed, and the preparation was carried out multiple times. The Naoluotong capsules were then evaluated, and the following data were obtained:

[0128] Drying temperature in S17 70℃ 75℃ 80℃ 85℃ 90℃ 95℃ Product has vasodilating effect 76.5 84.1 88.3 90.1 86.9 82.5 Product shelf life 71.3 79.2 86.5 90.1 90.7 91.3

[0129] As can be seen from the above, the drying temperature in S17 has a significant relationship with the product's vasodilatory effect and shelf life. When the drying temperature is between 70 and 95°C, it is always directly proportional to the product's shelf life. When the drying temperature is between 85 and 95°C, the product's vasodilatory effect is weakened, and the shelf life increases relatively slowly in this range. Taking all factors into consideration, the preferred drying temperature in S17 is 85°C.

[0130] The above description represents a preferred embodiment of the present invention, but it is not the only specific embodiment of the present invention. The scope of protection of the present invention is not limited thereto. Any equivalent or equivalent substitutions or changes made by those skilled in the art within the scope of the technology disclosed in the present invention, in combination with existing technology or common knowledge, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A production equipment of Naoluotong capsule, comprising a treatment tank (1), characterized in that, The processing tank (1) top is provided with lifting chamber (10), processing tank (1) one side outer wall is provided with feeding hopper (11), processing tank (1) is provided with the poking mechanism, the poking mechanism includes poking main shaft (18) and poking lever (15), the processing tank (1) one side outer wall is fixed with poking motor (2), the poking main shaft (18) rotationally connected to the output end of poking motor (2), the poking lever (15) is uniformly fixed to the circumferential outer wall of poking main shaft (18);The poking lever (15) one side outer wall is provided with the extension rod (17) extending to one side, and the poking lever (15) and extension rod (17) constitute y type structure, and the distance from the outer end of extension rod (17) to poking main shaft (18) is less than the length of poking lever (15);The processing tank (1) top outer wall is installed with lifting motor (23) through screw, the output end of lifting motor (23) is rotationally connected with lifting screw (24), and the top end of lifting screw (24) is rotationally connected to the inner wall of lifting chamber (10) top, the outer wall of lifting screw (24) is connected with lifting frame (26) through screw thread, and the inner wall of the other end of lifting frame (26) is slidably connected to the outer wall of guide rod (25), the center position of lifting frame (26) is provided with mounting bracket (21), the bottom outer wall of mounting bracket (21) is fixed with equidistantly distributed cutting knife (14), and the cutting knife (14) and poking lever (15) are staggered and arranged.

2. The production apparatus of the Naoluotong capsule according to claim 1, characterized in that, The poking lever (15) and extension rod (17) are provided with guide plate (16), adjacent guide plate (16) constitutes eight character structure, and the stirring blade (22) is arranged between the poking lever (15).

3. The production apparatus of the Naoluotong capsule according to claim 2, characterized in that, The processing tank (1) bottom is fixed with first support frame (3) for supporting processing tank (1), and the filter door (20) is hingedly connected to the inner wall of processing tank (1) bottom through hinge, the outer wall of filter door (20) is provided with uniformly distributed leak hole (29), the other side outer wall of filter door (20) is hingedly connected with sealing door (28) through hinge, and the sealing plug (27) matched with leak hole (29) is bonded to the top outer wall of sealing door (28);The sealing rubber pad (19) matched with the shape of filter door (20) is embeddedly installed on the inner wall of processing tank (1) bottom.

Citation Information

Patent Citations

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