A soluble microneedle patch for treating nail fungal infection and a preparation method thereof
By designing soluble microneedle patches and using macromolecules of different molecular weights as the matrix, combined with antifungal and keratin-softening ingredients, the problem of poor permeability and unsatisfactory sustained-release effect in existing treatments for onychomycosis is solved, achieving significant effects of rapid sterilization and long-term efficacy.
CN116803385BActive Publication Date: 2026-07-03JIANGSU JICUI FUNCTIONAL MATERIALS RES INST CO LTD +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGSU JICUI FUNCTIONAL MATERIALS RES INST CO LTD
- Filing Date
- 2023-07-07
- Publication Date
- 2026-07-03
Smart Images
Figure BDA0004326732460000171 
Figure HDA0004326732470000011 
Figure HDA0004326732470000012
Abstract
This application provides a soluble microneedle patch for treating nail fungal infections. The microneedles in the patch comprise: 0.1-7% of a drug component by weight, with the remainder being a matrix component. The matrix component comprises macromolecules with polar bonds having an average molecular weight of 0.05-30,000, macromolecules with polar bonds having an average molecular weight of 100,000-900,000, and macromolecules with polar bonds having an average molecular weight of 1,000,000-2,600,000. The drug component and microneedles work together to allow the drug to penetrate the nail plate directly to the deep connective tissue of the nail bed, killing the fungus. The patch exhibits high effective drug concentration, strong transdermal ability, significant therapeutic effect, no irritation, and no toxic side effects. Furthermore, the microneedles demonstrate excellent short-term rapid treatment and long-term sustained-release therapeutic effects.
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