A process for the manufacture of a water dispersible granule comprising a high melting point technical and a low melting point technical

Abstract

The application belongs to the field of pesticide preparation, and particularly relates to a processing method of water dispersible granules containing high-melting-point raw materials and low-melting-point raw materials, which is completed by adopting the following steps: ①processing high-melting-point raw materials and additives into mother powder through airflow crushing; ②processing low-melting-point raw materials and additives into high-content mother liquid through wet grinding; ③mixing the mother powder and the mother liquid, and performing kneading granulation to finally obtain the required product. The above method solves the processing problem of the water dispersible granules containing high-melting-point raw materials and low-melting-point raw materials, and can normally produce in hot summer, greatly improves the qualified rate of the product, and avoids the waste of manpower and material resources.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of pesticide formulations, and particularly relates to a processing method of a water dispersible granule containing high-melting-point technical material and low-melting-point technical material. BACKGROUND

[0002] With the improvement of people's environmental awareness, the pollution of chemical pesticides has become a serious social problem. Today, chemical pesticides cannot be replaced, and how to minimize the pollution of chemical pesticides to the environment is urgent. The development of environmentally friendly pesticide formulations can reduce the pollution of chemical pesticides to the environment.

[0003] The water dispersible granule is a solid preparation that can be dispersed in water, has certain strength and hardness, produces less dust, and does not need solvent, which is relatively safe to operators and the environment. The basic production process of the water dispersible granule includes a crushing process, a kneading process and a granulating process. The crushing process is an important process, and the material particles need to be crushed to a particle size D95 of less than 12 um to ensure a high suspension rate. In the crushing process, the airflow crusher needs to be adjusted to increase the frequency and power to meet the processing requirements. A large amount of heat will be generated in this process, especially at the classification wheel of the airflow crusher. When the room temperature is high in summer, the heat cannot be dissipated in time, which will cause some low-melting-point materials to be in a molten state or a melted state, resulting in a large number of non-disintegrating large particles after the subsequent material kneading and granulating, which will affect the efficacy and block the spray head.

[0004] In addition, in the process of using pesticides, in order to improve the efficacy, multiple active ingredients are often compounded to form a water dispersible granule. When the composition contains both low-melting-point technical material and high-melting-point technical material, the conventional method for preparing the water dispersible granule will also produce non-disintegrating large particles, resulting in unqualified products, such as tebuconazole·trifloxystrobin water dispersible granule or boscalid·pyraclostrobin water dispersible granule.

[0005] Tebuconazole·trifloxystrobin water dispersible granule and boscalid·pyraclostrobin water dispersible granule are two kinds of pesticides with good disease control effect. Since the technical material of trifloxystrobin (melting point 73℃) and pyraclostrobin (melting point 63.7-65.2℃) has a low melting point, non-disintegrating large particles will appear after crushing and granulating in the workshop in summer, resulting in unqualified products and wasting a large amount of manpower and resources. It is urgent to solve the problem of summer workshop production of water dispersible granules containing low-melting-point technical material, improve the qualified rate of products, and ensure the efficacy of products. SUMMARY

[0006] The present application provides a processing method of water dispersible granules containing high-melting-point raw chemicals and low-melting-point raw chemicals, which is completed by the following steps: ① high-melting-point raw chemicals and additives are processed into mother powder by airflow pulverization, and low-melting-point raw chemicals and additives are processed into high-content mother liquid by wet grinding; ② the mother powder and the mother liquid are mixed in a certain proportion, and are subjected to kneading granulation to obtain the required product. The processing problem of low-melting-point water dispersible granules such as trifloxystrobin and pyraclostrobin is solved, and the products can be normally produced in hot summer, so that the qualified rate of the products is greatly improved, the waste of manpower and material resources is avoided, and the on-demand production of low-melting-point water dispersible granules is achieved.

[0007] In order to solve the above problems, the technical scheme of the present application is:

[0008] The processing method of water dispersible granules containing high-melting-point raw chemicals and low-melting-point raw chemicals comprises the following steps:

[0009] ① high-melting-point raw chemicals and additives are processed into mother powder by airflow pulverization;

[0010] ② low-melting-point raw chemicals and additives are processed into high-content mother liquid by wet grinding;

[0011] ③ the mother powder and the mother liquid are mixed, and are subjected to kneading granulation to obtain the required product;

[0012] In the above steps, the wet grinding can well control the grinding temperature and ensure the processing stability of the low-melting-point raw chemicals; during the pulverization process of the airflow pulverizer, high temperature is locally generated, which causes the low-melting-point raw chemicals to easily melt, and there are non-disintegrating particles after granulation; the step-by-step processing can also reduce the pulverization amount of solid materials and the generation amount of dust, which is beneficial to the safety of the working environment.

[0013] As a preferred scheme, the high-melting-point raw chemicals and additives are pulverized to a particle size D95≤12um in step ①.

[0014] As a preferred scheme, the low-melting-point raw chemicals and additives are ground to a particle size D95≤5um in step ②, and the temperature during the grinding process is controlled below 25℃.

[0015] As a preferred scheme, the additives in steps ① and ② include wetting agents, dispersants, fillers and water.

[0016] As a preferred scheme, the wetting agent is at least one of low-foaming wetting agent GY-W07 (Beijing Guangyin Yinan Chemical) and anionic wetting agent GY-W04 (Beijing Guangyin Yinan Chemical).

[0017] As a preferred solution, the dispersant is at least one of comb-shaped polycarboxylate dispersant SP-DF2222 (Jiangsu Chengyu Chemical, solid content 22%), polycarboxylate high molecular dispersant SP-DF2238 (Jiangsu Chengyu Chemical, solid content 30%), polycarboxylate dispersant SP-2872 (Jiangsu Chengyu Chemical), carboxylate dispersant GY-D800 (Beijing Guangyin Yinan Chemical), modified naphthalene sulfonate dispersant GY-KD10 (Beijing Guangyin Yinan Chemical), modified lignin dispersant GY-DM18 (Beijing Guangyin Yinan Chemical), polycarboxylate high molecular dispersant GY-D07 (Beijing Guangyin Yinan Chemical, solid content 30%).

[0018] As a preferred solution, the filler is at least one of ammonium sulfate, oxidized corn starch, kaolin, and precipitated barium sulfate.

[0019] As a preferred solution, the water dispersible granule is tebuconazole·fampek water dispersible granule or boscalid·pyraclostrobin water dispersible granule.

[0020] As a specific embodiment, when the water dispersible granule is tebuconazole·fampek water dispersible granule, the specific processing steps are as follows:

[0021] 1) First, stir the deionized water, dispersant, wetting agent, fampek technical material (low melting point), and filler uniformly;

[0022] 2) Add the mixed solution in step (1) to a sand mill for grinding until the particle size D95 is ≤5um, and the temperature during grinding is controlled below 25℃. After grinding, a high-content mother liquor is obtained;

[0023] 3) Mix the dispersant, wetting agent, tebuconazole technical material (high melting point), and filler uniformly, and then crush them by an air flow crusher until the particle size D95 is ≤12um. After crushing, a mother powder is obtained;

[0024] 4) Mix and knead the high-content mother liquor prepared in step (2) and the mother powder prepared in step (3), and then granulate. After drying the granules, the desired water dispersible granule is obtained.

[0025] As a specific embodiment, when the water dispersible granule is boscalid·pyraclostrobin water dispersible granule, the specific processing steps are as follows:

[0026] 1) First, stir the deionized water, dispersant, wetting agent, pyraclostrobin technical material (low melting point), and filler uniformly;

[0027] 2) Add the mixed solution in step (1) to a sand mill for grinding until the particle size D95 is ≤5um, and the temperature during grinding is controlled below 25℃. After grinding, a high-content mother liquor is obtained;

[0028] 3) the dispersant, wetting agent, flumetover (high melting point) and filler are mixed uniformly, and are crushed by an airflow crusher to a particle size D95≤12um, and the crushing is completed to obtain the base powder;

[0029] 4) the high content mother liquor prepared in step (2) and the base powder prepared in step (3) are mixed, kneaded and granulated, and the granules are dried to obtain the required water dispersible granules.

[0030] Compared with the prior art, the present application has the beneficial effects of:

[0031] 1. The low melting point raw material is processed into a high content mother liquor by wet grinding, and the temperature is controllable, so that the problems of melting or melting of the low melting point raw material due to excessively high temperature in the airflow crushing process, and a large number of disintegrated or non-disintegrated products, can be avoided, and the product can be normally produced in hot summer, and the qualified rate of the product is significantly improved, and the waste of manpower and material resources is reduced. The prepared water dispersible granules are completely disintegrated, have high suspension rate, and the effective component suspension rate is above 96.5%, which is beneficial to the exertion of the efficacy of the medicament.

[0032] 2. The crushing of solid materials is reduced, and the generation of dust is reduced, which is beneficial to the health and safety of the operators. BRIEF DESCRIPTION OF DRAWINGS

[0033] Figure 1 The physical photos of the disintegration test of the examples in the test examples and the comparative examples are shown in the following table,

[0034] In the figure, left 1 is the physical photo of the disintegration test of the water dispersible granules of the comparative example 1, left 2 is the physical photo of the disintegration test of the water dispersible granules of the comparative example 2, and left 3 is the physical photo of the disintegration test of the water dispersible granules of the example 1. DETAILED DESCRIPTION

[0035] The technical solutions in the examples of the present application will be described clearly and completely below. Obviously, the described examples are only a part of the examples of the present application, but not all the examples. Based on the examples in the present application, all the other examples obtained by the ordinary skilled in the art without creative labor belong to the protection scope of the present application. The experimental methods used in the following examples are the conventional methods if no special description is given, and the percentages are all weight percentages.

[0036] The present application is explained and described below by taking the following two kinds of water dispersible granules as examples.

[0037] The active ingredients of the water dispersible granules 1 are tebuconazole and trifloxystrobin, and the content of tebuconazole is 10-55% by weight, the content of trifloxystrobin is 3-30% by weight, the rest is 6-20% of the agriculturally acceptable dispersant and wetting agent, and the rest is 100% of the filler and water and the like.

[0038] Water dispersible granule 2: its active ingredient is boscalid and pyraclostrobin, the content of boscalid is 8-35% by weight percentage, the content of pyraclostrobin is 4-20%, the rest is 8-25% of agriculturally acceptable dispersant and wetting agent, and the rest is 100% of filler and water.

[0039] In the following examples and comparative examples:

[0040] When wet grinding, Shanghai Fudeli Energy Technology Co., Ltd. FDS-60 sand mill is used, and the grinding temperature is below 25℃; the air flow crushing equipment uses Suzhou Minghongwei Machinery Equipment Manufacturing Co., Ltd. QSF-600 air flow crusher.

[0041] The following examples were carried out on June 7, 2023 (air temperature 24-35℃) in the preparation workshop of Shandong Jingbo Agricultural Chemical Technology Co., Ltd.

[0042] Preparation of 75% tebuconazole·flusilazole water dispersible granule (50+25)

[0043] 50% flusilazole mother liquor composition: flusilazole technical material, 50%; SP-DF2222, 15%; SP-DF2238, 10%; GY-W07, 1%; deionized water, supplement to 100%.

[0044] 70% tebuconazole mother powder composition: tebuconazole technical material, 70%; GY-D800, 8%; GY-KD10, 2%, GY-W04, 1%; ammonium sulfate, 10%; oxidized corn starch, supplement to 100%.

[0045] The above water dispersible granule is prepared by the following steps:

[0046] 1) First, deionized water, SP-DF2222, SP-DF2238, GY-W07, flusilazole technical material are stirred uniformly;

[0047] 2) The mixed solution in step (1) is added to the sand mill for grinding, until the particle size D95≤5um, the temperature is controlled below 25℃ during the grinding process, and the 50% flusilazole mother liquor is obtained after grinding;

[0048] 3) Mix GY-D800, GY-KD10, GY-W04, ammonium sulfate, oxidized corn starch, tebuconazole technical material uniformly, and crush by air flow crusher, until the particle size D95≤12um, and the 70% tebuconazole mother powder is obtained after crushing;

[0049] 4) Weigh 50g flusilazole mother liquor and 72g tebuconazole mother powder, mix, knead and granulate, and the 75% tebuconazole·flusilazole water dispersible granule is obtained after drying the granules.

[0050] Since the solid content of the dispersant used in the preparation of 50% trifloxystrobin mother liquor is low, the rest is moisture, which will be dried in the granulation drying process; the moisture content of the system should be maintained between 17-22% during mixing. When the powder is dry during the mixing and granulation process, a small amount of water can be added appropriately for mixing and granulation.

[0051] Example 2 Preparation of 38% amisolanilide · pyraclostrobin water dispersible granules (25+13)

[0052] 30% pyraclostrobin mother liquor composition: pyraclostrobin technical material, 30%; SP-DF2222, 5%; SP-DF2238, 15%; GY-KD10, 2%; precipitated barium sulfate, 5%, deionized water, supplement to 100%.

[0053] 31% amisolanilide mother powder composition: amisolanilide technical material, 31%; GY-D800, 5%; GY-DM18, 5%, GY-W04, 1%; oxidized corn starch, 15%; ammonium sulfate, supplement to 100%.

[0054] The above water dispersible granules are prepared by the following steps:

[0055] 1) First, deionized water, SP-DF2222, SP-DF2238, GY-KD10, precipitated barium sulfate, pyraclostrobin technical material, are stirred uniformly;

[0056] 2) The mixed solution in step (1) is added to a sand mill for grinding until the particle size D95 is ≤5um, and the temperature during grinding is controlled below 25℃. After grinding, 30% pyraclostrobin mother liquor is obtained;

[0057] 3) GY-D800, GY-DM18, GY-W04, ammonium sulfate, oxidized corn starch, amisolanilide technical material are mixed uniformly, and are crushed by an air flow crusher until the particle size D95 is ≤12um. After crushing, 31% amisolanilide mother powder is obtained;

[0058] 4) 43.5g pyraclostrobin mother liquor and 81g amisolanilide mother powder are weighed and mixed, kneaded and granulated. After drying the granules, the desired water dispersible granules are obtained.

[0059] Since the solid content of the dispersant used in the preparation of 30% pyraclostrobin mother liquor is low, the rest is moisture, which will be dried in the granulation drying process; the moisture content of the system should be maintained between 18-25% during mixing. When the powder is dry during the mixing and granulation process, a small amount of water can be added appropriately for mixing and granulation.

[0060] Example 3 Preparation of 60% tebuconazole · trifloxystrobin water dispersible granules (45+15)

[0061] 40% trifloxystrobin suspension concentrate composition: trifloxystrobin technical material, 40%; SP-DF2222, 12%; SP-DF2238, 8%; GY-W07, 1%; deionized water, balance to 100%.

[0062] 54.4% tebuconazole base powder composition: tebuconazole technical material, 54.4%; GY-D800, 7%; GY-KD10, 2%; GY-W04, 1%; ammonium sulfate, 15%; oxidized corn starch, balance to 100%.

[0063] The above water dispersible granule is prepared by the following steps:

[0064] 1) First, deionized water, SP-DF2222, SP-DF2238, GY-W07, trifloxystrobin technical material, are stirred uniformly;

[0065] 2) The mixture in step (1) is added to a sand mill for grinding until the particle size D95 is ≤5 um, and the temperature is controlled below 25°C during the grinding process. After grinding is completed, 40% trifloxystrobin suspension concentrate is obtained;

[0066] 3) GY-D800, GY-KD10, GY-W04, ammonium sulfate, oxidized corn starch, tebuconazole technical material are mixed uniformly, and are pulverized by an air flow pulverizer until the particle size D95 is ≤12 um. After pulverization is completed, 54.4% tebuconazole base powder is obtained;

[0067] 4) 50 g of trifloxystrobin suspension concentrate and 110.3 g of tebuconazole base powder are weighed and mixed, kneaded, and granulated. After the granules are dried, 60% tebuconazole·trifloxystrobin water dispersible granule is obtained.

[0068] Since the dispersants used in the preparation of 40% trifloxystrobin suspension concentrate have a low solid content, the rest is water. During the granulation and drying process, the water will be baked off. During the mixing process, the water content of the system should be maintained between 17-22%. When the powder is dry during the mixing and granulation process, a small amount of water can be added appropriately for mixing and granulation.

[0069] Example 4 Preparation of 30% amisolanilide·pyraclostrobin water dispersible granule (20+10)

[0070] 20% pyraclostrobin suspension concentrate composition: pyraclostrobin technical material, 20%; SP-DF2222, 10%; SP-DF2238, 10%; GY-KD10, 2%; precipitated barium sulfate, 5%; deionized water, balance to 100%.

[0071] 23.8% of flutolanil mother powder composition: flutolanil technical, 23.8%; GY-D800, 4%; GY-DM18, 5%; GY-W04, 2%; oxidized corn starch, 15%; ammonium sulfate, make up to 100%.

[0072] The above water dispersible granules are prepared by the following steps:

[0073] 1) First, deionized water, SP-DF2222, SP-DF2238, GY-KD10, precipitated barium sulfate, pyraclostrobin technical, are stirred uniformly;

[0074] 2) The mixture in step (1) is added to a sand mill for grinding until the particle size D95 is ≤5um, and the temperature is controlled below 25°C during the grinding process. After grinding, 20% pyraclostrobin mother liquor is obtained;

[0075] 3) GY-D800, GY-DM18, GY-W04, ammonium sulfate, oxidized corn starch, flutolanil technical are mixed uniformly, and are crushed by an air flow crusher until the particle size D95 is ≤12um. After crushing, 23.8% flutolanil mother powder is obtained;

[0076] 4) 40g of pyraclostrobin mother liquor and 67.2g of flutolanil mother powder are weighed and mixed, kneaded, and granulated. After drying the granules, the desired water dispersible granules are obtained.

[0077] Since the dispersant used in the preparation of 20% pyraclostrobin mother liquor has a low solid content, the rest is water. During the granulation and drying process, the water will be dried out. During the mixing process, the water content of the system should be maintained between 18-25%. When the powder is dry during the mixing and granulation process, a small amount of water can be added appropriately for mixing and granulation.

[0078] Comparative Example 1 75% of tebuconazole·triflumizole water dispersible granules

[0079] Triflumizole technical, 25%; tebuconazole technical, 50%; SP-2872, 5%; GY-DM18, 5%; GY-W04, 2%; ammonium sulfate, 5%; oxidized corn starch, make up to 100%.

[0080] The above water dispersible granules are prepared by the following steps:

[0081] 1) SP-2872, GY-DM18, GY-W04, ammonium sulfate, oxidized corn starch, tebuconazole technical, triflumizole technical are stirred uniformly;

[0082] 2) The mixture in step (1) is added to an air flow crusher for crushing until the particle size D95 is ≤12um. 75% tebuconazole·triflumizole mother powder is obtained;

[0083] 3) The mother powder of step (2) is mixed, kneaded, and granulated, and the granules are dried to obtain the required water dispersible granules.

[0084] Comparative Example 1 was processed using a conventional water dispersible granule processing method compared to Example 1.

[0085] Comparative Example 2 38% boscalid·pyraclostrobin water dispersible granules

[0086] Pyraclostrobin technical material, 13%; boscalid technical material, 25%; GY-D800, 10%; GY-KD10, 5%, GY-W04, 2%; oxidized corn starch, 15%; ammonium sulfate, to make up 100%.

[0087] The above water dispersible granules are prepared by the following method:

[0088] 1) GY-D800, GY-KD10, GY-W04, ammonium sulfate, oxidized corn starch, boscalid technical material, and pyraclostrobin technical material are stirred uniformly;

[0089] 2) The mixture of step (1) is added to an air jet mill and pulverized until the particle size D95 is ≤12 um; 38% boscalid·pyraclostrobin mother powder is obtained;

[0090] 3) The mother powder of step (2) is mixed, kneaded, and granulated, and the granules are dried to obtain the required water dispersible granules.

[0091] Comparative Example 2 was processed using a conventional water dispersible granule processing method compared to Example 2.

[0092] Test Example

[0093] The above examples and comparative examples were subjected to disintegration testing: 0.5 g of sample granules were added to a 100 ml graduated cylinder (cylinder height 22.5 cm, inner diameter 28 mm) containing 90 ml of distilled water at 25°C, the middle of the graduated cylinder was clamped, and it was rotated at a speed of 8 r / min along the center at a uniform speed until the sample disintegrated in the water. When the sample completely disintegrated, no particles were observed by eye, and when the sample could not completely disintegrate, there were many non-disintegrated particles at the bottom, as shown in the following figure: Figure 1 The left two figures (Comparative Example 1 and Comparative Example 2) are not completely disintegrated particles, and the rightmost figure (Example 1) is completely disintegrated particles.

[0094] The above examples and comparative examples were subjected to disintegration testing according to the above method, and it was found that the water dispersible granules containing low-melting-point technical material processed using the method of the present application disintegrated well and had no obvious particles, and the specific results are shown in the following table.

[0095] Example and Comparative Example Disintegration Testing

[0096] Test samples Disintegration performance determination Example 1 Completely disintegratable Example 2 Completely disintegratable Example 3 Completely disintegratable Example 4 Completely disintegratable Comparative Example 1 Not completely disintegratable Comparative Example 2 Not completely disintegratable

[0097] Through the above disintegration test, it is found that when the water dispersible granules containing low-melting raw materials are processed by the conventional method, the low-melting raw materials will melt or fuse during the air flow crushing process if the temperature is too high, and the disintegration of the granules will not be complete. When the low-melting raw materials are processed into mother liquor, the temperature during the process is controllable, and the disintegration of the granules after processing is complete.

[0098] Storage stability test: In order to verify the storage stability of the water dispersible granules processed by the method of the present application, the samples were subjected to heat storage stability test. The samples were sealed in aluminum foil bags and placed in a constant temperature oven at 54°C for 14 days. After cooling to room temperature, the content, suspension rate and disintegration of the samples after heat storage were detected. The samples after cold storage were detected for comparison.

[0099] The heat storage stability test of Example 1, Example 2, Comparative Examples 1-2 was carried out to verify the specific results as shown in the following table.

[0100] Test sample heat storage stability results

[0101]

[0102] If the suspension rate of the pesticide is too low, the pesticide particles will quickly settle at the bottom of the sprayer, causing uneven concentration in the field, affecting the control effect, and even causing pesticide damage.

[0103] Comparative Examples 1 and 2 use the conventional water dispersible granule processing method. Since the low-melting raw materials and high-melting raw materials are crushed at the same time during the processing of the conventional water dispersible granules, the high temperature during the crushing process causes the low-melting raw materials to melt or fuse, thereby affecting the disintegration and suspension performance of the product.

[0104] From the above table, it can be seen that the water dispersible granules containing low-melting raw materials processed by the method of the present application have good stability and can meet the application of the product.

[0105] For those skilled in the art, the specific embodiments are only exemplary descriptions of the present application, and it is obvious that the specific implementation of the present application is not limited by the above method. Any non-essential improvement or direct application of the concept and technical solution of the present application to other fields without improvement is within the protection scope of the present application.

Claims

1. A method for processing water-dispersible granules containing high-melting-point and low-melting-point active ingredients, characterized in that: Includes the following steps: ① The high-melting-point active ingredient and additives are processed into master powder by air jet milling; ② The low-melting-point active ingredient and auxiliaries are processed into a high-content mother liquor by wet grinding; ③ The mother powder and mother liquor are mixed, kneaded and granulated to finally obtain the desired product; Step ① involves pulverizing the high-melting-point active ingredient and adjuvants to a particle size D95≤12um; In step ②, the low-melting-point active ingredient and adjuvants are ground to a particle size D95≤5um, and the temperature is controlled below 25℃ during the grinding process. The additives mentioned in steps ① and ② include wetting agents, dispersants, fillers, and water.

2. The processing method of the water-dispersible granules according to claim 1, characterized in that: The wetting agent is at least one of the following: low-foaming wetting agent GY-W07 and anionic wetting agent GY-W04.

3. The processing method of the water-dispersible granules according to claim 1, characterized in that: The dispersant is at least one of the following: comb-type polycarboxylate dispersant SP-DF2222, polycarboxylate polymeric dispersant SP-DF2238, polycarboxylate dispersant SP-2872, carboxylate dispersant GY-D800, modified naphthalene sulfonate dispersant GY-KD10, modified lignin dispersant GY-DM18, and polycarboxylate polymeric dispersant GY-D07.

4. The processing method of the water-dispersible granules according to claim 1, characterized in that: The filler is at least one of ammonium sulfate, oxidized corn starch, kaolin, and precipitated barium sulfate.

5. The processing method of the water-dispersible granules according to claim 1, characterized in that: The water-dispersible granules are tebuconazole-oxime ester water-dispersible granules or cyprodinil-pyraclostrobin-oxime ester water-dispersible granules.

6. The processing method of the water-dispersible granules according to claim 5, characterized in that: When the water-dispersible granules are tebuconazole•oxime procymidone water-dispersible granules, the specific processing steps are as follows: 1) First, mix the deionized water, dispersant, wetting agent, azoxystrobin technical and filler evenly; 2) Add the mixture from step (1) to a sand mill for grinding until the particle size D95≤5um. During the grinding process, the temperature is controlled below 25℃. After grinding, a high-content mother liquor is obtained. 3) Mix the dispersant, wetting agent, tebuconazole technical and filler evenly, and then pulverize them using an air jet mill until the particle size D95≤12um. The pulverized powder is obtained after pulverization. 4) Mix, knead and granulate the high-content mother liquor obtained in step (2) and the mother powder prepared in step (3). After drying the granules, the desired water-dispersible granules are obtained.

7. The processing method of the water-dispersible granules according to claim 5, characterized in that: When the water-dispersible granules are cyazofamid•pyraclostrobin water-dispersible granules, the specific processing steps are as follows: 1) First, mix deionized water, dispersant, wetting agent, pyraclostrobin technical and filler evenly; 2) Add the mixture from step (1) to a sand mill for grinding until the particle size D95≤5um. During the grinding process, the temperature is controlled below 25℃. After grinding, a high-content mother liquor is obtained. 3) Mix the dispersant, wetting agent, cyazofamid technical and filler evenly, and then pulverize them using an air jet mill until the particle size D95≤12um. The pulverized powder is obtained after pulverization. 4) Mix, knead and granulate the high-content mother liquor obtained in step (2) and the mother powder prepared in step (3). After drying the granules, the desired water-dispersible granules are obtained.

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