An anti-fatigue composition, its preparation method and application

Abstract

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to an anti-fatigue composition, which comprises the following raw materials in parts by weight: 5-15 parts of artemisia argyi, 10-20 parts of cistanche, 5-10 parts of pueraria, 5-15 parts of rehmannia, 10-20 parts of astragalus, 10-20 parts of epimedium, 12-18 parts of clove, 5-15 parts of psyllium, 5-12 parts of ginger, 5-15 parts of cassia, 5-12 parts of semen bellicidae, and 5-12 parts of licorice. The composition can supplement the body energy, has the functions of warming and tonifying kidney yang, strengthening muscles and bones, and regulating water passage, and can effectively relieve fatigue and improve the exercise endurance of the body.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and more specifically, to an anti-fatigue composition, its preparation method, and its application. Background Technology

[0002] Fatigue is a physiological phenomenon that occurs after a certain stage of physical or mental labor, indicating an inability to maintain the body at a specific level or to continue the expected intensity of work. Fatigue can lead to symptoms such as decreased athletic performance, low work efficiency, and poor mental state. It is especially prevalent in modern, high-intensity urban work environments with fast-paced lifestyles.

[0003] Products on the market for relieving physical fatigue are mainly divided into two categories: Western medicine and traditional Chinese medicine. Western medicine treats the symptoms and is fast-acting, but it has significant side effects, such as damaging organs or causing drug dependence. Traditional Chinese medicine emphasizes a holistic approach and treatment, which has a comprehensive regulatory effect on those suffering from physical fatigue. In addition, most people with physical fatigue syndrome require long-term treatment and recuperation. Pure natural Chinese herbal medicines with health benefits have milder effects, are less likely to cause drug resistance, and are suitable for long-term use.

[0004] Chinese patent CN107801831A discloses an oyster peptide compressed candy, which includes oyster peptide, black ginger, cinnamon, polygonatum, ginseng, yam, cordyceps militaris, cistanche deserticola, black goji berries, arginine, and other excipients, and can relieve fatigue and enhance physical strength.

[0005] Chinese patent CN115054673A discloses a traditional Chinese medicine compound composition for combating fatigue, which consists of ginseng, polygonatum, astragalus, white hyacinth bean, yam, poria cocos, dried ginger, tangerine peel and licorice, and improves physical function, enhances physical strength and relieves physical fatigue.

[0006] The aforementioned patented traditional Chinese medicine preparations lack specificity, focusing on tonification rather than regulation, and failing to address the root cause of fatigue. Therefore, there is an urgent need to develop traditional Chinese medicine preparations that can effectively alleviate and eliminate fatigue, with a focus on regulating the overall functional state of the body. Summary of the Invention

[0007] In view of the shortcomings of the existing technology, the purpose of this invention is to provide an anti-fatigue composition that has good anti-fatigue effect, is safe to use, and has few toxic side effects.

[0008] To achieve the above objectives, the present invention provides the following technical solution:

[0009] An anti-fatigue composition comprising the following raw materials in parts by weight: 5-15 parts of Artemisia argyi, 10-20 parts of Cistanche deserticola, 5-10 parts of Pueraria lobata, 5-15 parts of Rehmannia glutinosa, 10-20 parts of Astragalus membranaceus, 10-20 parts of Epimedium brevicornu, 12-18 parts of Clove, 5-15 parts of Plantago asiatica, 5-12 parts of Curcuma longa, 5-15 parts of Cinnamomum cassia, 5-12 parts of Cuscuta chinensis, and 5-12 parts of Glycyrrhiza uralensis.

[0010] The pharmacological effects of each ingredient in the formula are as follows:

[0011] Artemisia argyi: Its properties and channels are bitter and pungent, and warm in nature. It enters the liver, spleen, and kidney channels. Its bitter, drying, and pungent properties disperse and regulate qi and blood, warm the channels, dispel cold and dampness, and relieve cold pain.

[0012] Cistanche deserticola: sweet, salty, and warm in nature. It enters the kidney and large intestine meridians. It tonifies kidney yang, nourishes essence and blood, and moistens the intestines to relieve constipation. It is used for impotence, infertility, lower back and knee weakness, muscle and bone weakness, and constipation due to intestinal dryness.

[0013] Kudzu root: sweet, pungent, and cool in nature. It enters the spleen, stomach, and lung meridians. It relieves muscle tension and reduces fever, promotes fluid production and quenches thirst, promotes rash eruption, raises yang and stops diarrhea, unblocks meridians and collaterals, and detoxifies alcohol. It is used for exogenous fever and headache, stiff neck and back pain, thirst, diabetes, incomplete measles eruption, dysentery, diarrhea, dizziness and headache, hemiplegia due to stroke, chest pain, and alcohol poisoning.

[0014] Rehmannia root: Sweet, slightly warm. Enters the liver and kidney meridians. Nourishes yin and blood, replenishes essence and marrow. Used for liver and kidney yin deficiency, soreness and weakness of the lower back and knees, bone steaming fever, night sweats, seminal emission, internal heat and thirst, blood deficiency and chlorosis, palpitations, irregular menstruation, metrorrhagia, dizziness, tinnitus, and premature graying of hair.

[0015] Astragalus: Sweet, warm. Enters the lung and spleen meridians. Tonifies qi and strengthens the exterior, promotes diuresis and eliminates toxins, drains pus, and promotes tissue regeneration. Used for qi deficiency and fatigue, poor appetite and loose stools, sinking of middle qi, chronic diarrhea and rectal prolapse, hematochezia and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, carbuncles that are difficult to heal, chronic ulcers that do not heal, anemia and chlorosis, internal heat and thirst; proteinuria in chronic nephritis, and diabetes.

[0016] Epimedium: pungent, sweet, and warm. It enters the liver and kidney meridians. It tonifies kidney yang, strengthens tendons and bones, and dispels wind and dampness. It can be used for impotence, seminal emission, weakness of tendons and bones, rheumatic pain, numbness and contractures; and menopausal hypertension.

[0017] Clove: pungent, warm. It enters the lung, stomach, spleen, and kidney meridians. It lowers qi and stops hiccups, warms the middle jiao, dispels cold and relieves pain, and warms the kidneys and strengthens yang.

[0018] Plantain seed: Sweet, slightly cold. Enters the liver, kidney, lung, and small intestine meridians. Clears heat and promotes diuresis, eliminates dampness and relieves strangury, improves eyesight, and resolves phlegm. Used for edema and abdominal distension, painful urination due to heat, summer-heat diarrhea, red and swollen eyes, and cough with phlegm and heat.

[0019] Turmeric: It has a bitter and pungent taste and is warm in nature. It can break up blood stasis, promote qi circulation, relieve pain, and promote menstruation.

[0020] Cinnamon: pungent, sweet, and very hot in nature. It enters the kidney, spleen, heart, and liver meridians. It tonifies fire and assists yang, guides fire back to its source, dispels cold and relieves pain, and invigorates blood and regulates menstruation. It is used for impotence, cold uterus, cold pain in the lower back and knees, asthma due to kidney deficiency, dizziness due to yang deficiency, red eyes and sore throat, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency and cold, hernia due to cold, abdominal pain, amenorrhea, and dysmenorrhea.

[0021] Cuscuta seed: Sweet, warm. Enters the liver, kidney, and spleen meridians. Nourishes the liver and kidneys, strengthens essence and reduces urination, calms the fetus, improves eyesight, and stops diarrhea. Used for impotence, seminal emission, dribbling urination, enuresis, frequent urination, lower back and knee weakness, blurred vision and tinnitus, kidney deficiency with threatened abortion, fetal restlessness, and spleen and kidney deficiency with diarrhea; externally used to treat vitiligo.

[0022] Licorice: Sweet, neutral. It enters the heart, lung, spleen, and stomach meridians. It tonifies the spleen and replenishes qi, clears heat and detoxifies, resolves phlegm and relieves cough, alleviates spasms and pain, and harmonizes the effects of other herbs. It is used for spleen and stomach weakness, fatigue, palpitations, shortness of breath, cough with excessive phlegm, abdominal and limb spasms and pain, carbuncles and boils, and to alleviate the toxicity and harshness of other medications.

[0023] Preferably, the ingredients include the following parts by weight: 7-13 parts of Artemisia argyi, 13-17 parts of Cistanche deserticola, 7-8 parts of Pueraria lobata, 8-12 parts of Rehmannia glutinosa, 13-17 parts of Astragalus membranaceus, 13-17 parts of Epimedium brevicornu, 14-16 parts of Clove, 8-12 parts of Plantago asiatica, 5-10 parts of Curcuma longa, 5-12 parts of Cinnamomum cassia, 5-10 parts of Cuscuta chinensis, and 5-10 parts of Glycyrrhiza uralensis.

[0024] Preferably, the ingredients include the following parts by weight: 10 parts Artemisia argyi, 15 parts Cistanche deserticola, 8 parts Pueraria lobata, 10 parts Rehmannia glutinosa, 15 parts Astragalus membranaceus, 15 parts Epimedium brevicornu, 15 parts Clove, 10 parts Plantago asiatica, 8 parts Curcuma longa, 10 parts Cinnamomum cassia, 8 parts Cuscuta chinensis, and 8 parts Glycyrrhiza uralensis.

[0025] The second objective of this invention is to provide a method for preparing an anti-fatigue composition, which has the advantages of simple preparation and convenient operation, and includes the following steps:

[0026] (1) After accurately weighing each raw material, grind it into powder using a pulverizer and sieve it to a fineness of 20-40 mesh to obtain medicinal powder;

[0027] (2) Add the medicinal powder and extraction solvent to the extraction tank at a weight ratio of 1:(5-10), stir evenly, and soak for 100-150 minutes to obtain a mixture;

[0028] (3) Heat the mixture to 50-60℃, turn on the stirring, and extract by ultrasonication for 30-45 minutes. Centrifuge for the first time to remove the residue and collect the first-stage filtrate.

[0029] (4) Refrigerate the filtrate for 24 hours, centrifuge again to remove the residue, collect the secondary filtrate, concentrate under reduced pressure to obtain a thick paste, dry and pulverize the thick paste to obtain the anti-fatigue composition.

[0030] Preferably, the extraction solvent in step (2) is pure water.

[0031] Preferably, the refrigeration temperature in step (5) is 5-8°C.

[0032] The third objective of this invention is to provide an application of an anti-fatigue composition, specifically, to prepare a traditional Chinese medicine preparation by combining the above-mentioned anti-fatigue composition with pharmaceutically acceptable excipients, which has the advantage of a wide range of applications.

[0033] Preferably, the excipients are starch and stevia.

[0034] This application has the following beneficial effects:

[0035] (1) The formula is based on the theory of compatibility in traditional Chinese medicine. The principle of treatment is to nourish the liver and kidneys and replenish qi and blood. Cistanche deserticola, Epimedium and cinnamon are used as the chief herbs to replenish kidney yang and strengthen tendons and bones. Cuscuta chinensis is used as the assistant herbs to replenish kidney yang and replenish kidney essence. Plantago asiatica clears heat and promotes diuresis. Rehmannia glutinosa nourishes yin and replenishes kidneys. Clove is used to replenish liver and spleen and replenish essence and blood. Astragalus membranaceus and Rehmannia glutinosa replenish qi and blood. Licorice and clove guide the medicine to the meridians and work together to harmonize the medicine. When all the medicines are used together, the original qi is sufficient. The whole formula takes the spleen and kidneys as the foundation, warms yang and transforms qi, and also nourishes yin and spirit. It also takes into account the concurrent symptoms, so as to achieve the effects of warming and replenishing kidney yang, strengthening spleen and replenishing qi, and replenishing essence and marrow. Therefore, it can effectively relieve fatigue and improve the body's exercise endurance.

[0036] (2) Select low-irritant Chinese medicines as the main anti-fatigue raw materials and use ultrasonic heating extraction method to efficiently extract important active ingredients.

[0037] (3) Adding the anti-fatigue composition to traditional Chinese medicine preparations is beneficial to improving the anti-fatigue effect of traditional Chinese medicine preparations and to the widespread application of the anti-fatigue composition. Detailed Implementation

[0038] The present invention will be further described below with reference to embodiments, but the scope of protection of the present invention is not limited to the scope described in the embodiments. Example 1

[0039] An anti-fatigue composition comprises the following ingredients: 5g of Artemisia argyi, 10g of Cistanche deserticola, 5g of Pueraria lobata, 5g of Rehmannia glutinosa, 10g of Astragalus membranaceus, 10g of Epimedium brevicornu, 12g of Clove, 5g of Plantago asiatica, 5g of Curcuma longa, 5g of Cinnamomum cassia, 5g of Cuscuta chinensis, and 5g of Glycyrrhiza uralensis. The preparation method of the above anti-fatigue composition includes the following steps:

[0040] (1) After accurately weighing each raw material, grind it into powder using a pulverizer, sieve it to a fineness of 40 mesh, and continue to grind the residue until it passes through the sieve to obtain medicinal powder;

[0041] 2) Add the powdered medicine and pure water to the extraction tank at a weight ratio of 1:5, stir well, and soak for 100 minutes to obtain the mixture.

[0042] (3) Heat the mixture to 50°C, turn on the stirring, and extract it by ultrasonic extraction at 28KHZ and 1200W for 30 minutes. Centrifuge for the first time to remove the residue and collect the first-stage filtrate.

[0043] (4) Refrigerate the filtrate at 5-8℃ for 24 hours, centrifuge again to remove the residue, collect the secondary filtrate, concentrate it under reduced pressure at 60℃ to a thick paste with a relative density of 1.1-1.2, dry the paste under reduced pressure at 60℃ and pulverize it to obtain an anti-fatigue composition. Example 2

[0044] An anti-fatigue composition comprises the following ingredients: 7g of Artemisia argyi, 13g of Cistanche deserticola, 7g of Pueraria lobata, 8g of Rehmannia glutinosa, 10g of Astragalus membranaceus, 13g of Epimedium brevicornu, 14g of Clove, 8g of Plantago asiatica, 5g of Curcuma longa, 5g of Cinnamomum cassia, 5g of Cuscuta chinensis, and 5g of Glycyrrhiza uralensis. The preparation method of the above anti-fatigue composition includes the following steps:

[0045] (1) After accurately weighing each raw material, grind it into powder using a pulverizer, sieve it to a fineness of 40 mesh, and continue to grind the residue until it passes through the sieve to obtain medicinal powder;

[0046] (2) Add the powdered medicine and pure water to the extraction tank at a weight ratio of 1:10, stir evenly and soak for 150 minutes to obtain the mixture.

[0047] (3) Heat the mixture to 60°C, turn on the stirring, and extract it by ultrasonic extraction at 28KHZ and 1200W for 45 minutes. Centrifuge for the first time to remove the residue and collect the first-stage filtrate.

[0048] (4) Refrigerate the filtrate at 5-8℃ for 24 hours, centrifuge again to remove the residue, collect the secondary filtrate, concentrate it under reduced pressure at 60℃ to a thick paste with a relative density of 1.1-1.2, dry the paste under reduced pressure at 60℃ and pulverize it to obtain an anti-fatigue composition. Example 3

[0049] An anti-fatigue composition comprises the following raw materials: 10g of Artemisia argyi, 15g of Cistanche deserticola, 8g of Pueraria lobata, 10g of Rehmannia glutinosa, 15g of Astragalus membranaceus, 15g of Epimedium brevicornu, 15g of Clove, 10g of Plantago asiatica, 8g of Curcuma longa, 10g of Cinnamomum cassia, 8g of Cuscuta chinensis, and 8g of Glycyrrhiza uralensis. The preparation method of the above anti-fatigue composition includes the following steps:

[0050] (1) After accurately weighing each raw material, grind it into powder using a pulverizer, sieve it to a fineness of 40 mesh, and continue to grind the residue until it passes through the sieve to obtain medicinal powder;

[0051] (2) Add the powdered medicine and pure water to the extraction tank at a weight ratio of 1:6, stir evenly and soak for 120 minutes to obtain the mixture.

[0052] (3) Heat the mixture to 50°C, turn on the stirring, and extract it by ultrasonic extraction at 28KHZ and 1200W for 45 minutes. Centrifuge for the first time to remove the residue and collect the first-stage filtrate.

[0053] (4) Refrigerate the filtrate at 5-8℃ for 24 hours, centrifuge again to remove the residue, collect the secondary filtrate, concentrate it under reduced pressure at 60℃ to a thick paste with a relative density of 1.1-1.2, dry the paste under reduced pressure at 60℃ and pulverize it to obtain an anti-fatigue composition. Example 4

[0054] An anti-fatigue composition comprises the following ingredients: 13g of Artemisia argyi, 17g of Cistanche deserticola, 8g of Pueraria lobata, 12g of Rehmannia glutinosa, 17g of Astragalus membranaceus, 17g of Epimedium brevicornu, 16g of Clove, 12g of Plantago asiatica, 10g of Curcuma longa, 12g of Cinnamomum cassia, 10g of Cuscuta chinensis, and 10g of Glycyrrhiza uralensis. The preparation method of the above anti-fatigue composition includes the following steps:

[0055] (1) After accurately weighing each raw material, grind it into powder using a pulverizer, sieve it to a fineness of 40 mesh, and continue to grind the residue until it passes through the sieve to obtain medicinal powder;

[0056] (2) Add the powdered medicine and pure water to the extraction tank at a weight ratio of 1:6, stir evenly and soak for 120 minutes to obtain the mixture.

[0057] (3) Heat the mixture to 50°C, turn on the stirring, and extract it by ultrasonic extraction at 28KHZ and 1200W for 45 minutes. Centrifuge for the first time to remove the residue and collect the first-stage filtrate.

[0058] (4) Refrigerate the filtrate at 5-8℃ for 24 hours, centrifuge again to remove the residue, collect the secondary filtrate, concentrate it under reduced pressure at 60℃ to a thick paste with a relative density of 1.1-1.2, dry the paste under reduced pressure at 60℃ and pulverize it to obtain an anti-fatigue composition. Example 5

[0059] An anti-fatigue composition comprises the following raw materials: 15g of Artemisia argyi, 20g of Cistanche deserticola, 10g of Pueraria lobata, 15g of Rehmannia glutinosa, 20g of Astragalus membranaceus, 20g of Epimedium brevicornu, 18g of Clove, 15g of Plantago asiatica, 12g of Curcuma longa, 15g of Cinnamomum cassia, 12g of Cuscuta chinensis, and 12g of Glycyrrhiza uralensis. The preparation method of the above anti-fatigue composition includes the following steps:

[0060] (1) After accurately weighing each raw material, grind it into powder using a pulverizer, sieve it to a fineness of 40 mesh, and continue to grind the residue until it passes through the sieve to obtain medicinal powder;

[0061] (2) Add the powdered medicine and pure water to the extraction tank at a weight ratio of 1:6, stir evenly and soak for 120 minutes to obtain the mixture.

[0062] (3) Heat the mixture to 50°C, turn on the stirring, and extract it by ultrasonic extraction at 28KHZ and 1200W for 45 minutes. Centrifuge for the first time to remove the residue and collect the first-stage filtrate.

[0063] (4) Refrigerate the filtrate at 5-8℃ for 24 hours, centrifuge again to remove the residue, collect the secondary filtrate, concentrate it under reduced pressure at 60℃ to a thick paste with a relative density of 1.1-1.2, dry the paste under reduced pressure at 60℃ and pulverize it to obtain an anti-fatigue composition.

[0064] The above composition was mixed with starch and stevia at a mass ratio of 1:50:0.1, and then an appropriate amount of ethanol was added to prepare tablets.

[0065] Comparative Example 1

[0066] An anti-fatigue composition, the medicinal composition of which is compared with that of Example 3, contains 40g of Cistanche deserticola and does not contain Epimedium or cinnamon, and its preparation method is the same as that of Example 3.

[0067] Comparative Example 2

[0068] An anti-fatigue composition, the raw material composition of which is the same as that of Example 3, is 40g of Epimedium, does not contain Cistanche deserticola or cinnamon, and its preparation method is the same as that of Example 3.

[0069] Comparative Example 3

[0070] An anti-fatigue composition, the raw material composition of which is the same as that of Example 3, is 40g of cinnamon, does not contain epimedium or cistanche, and its preparation method is the same as that of Example 3.

[0071] The anti-fatigue compositions obtained in Examples 1-5 and Comparative Examples 1-3 can be mixed with starch and stevioside at a mass ratio of 1:50:0.1, and then an appropriate amount of ethanol can be added to prepare the corresponding dosage forms such as tablets, granules, and powders according to conventional methods.

[0072] Experimental methods

[0073] A weighted swimming test was conducted in accordance with the technical specifications for the inspection and evaluation of health food.

[0074] Experimental subjects: Adult mice weighing 18-22g were selected.

[0075] Equipment: The swimming box measures 50cm*50cm*40cm.

[0076] Experimental setup: Example group, comparative group, and blank control group were set up, with 10 mice in each group. Mice were administered 0.1g of sample (composition) by gavage (10g mouse). The sample administration period was 30 days. The blank control group received the same standard volume of physiological saline. Thirty minutes after the last sample administration, mice with a tail base loaded with 5% of their body weight in lead were placed in a swimming pool with a water depth of at least 30cm and a water temperature of 25±1℃. The time from the start of swimming to death was recorded, i.e., the weight-bearing swimming time. Other precautions are detailed in the guidelines. The weight-bearing swimming time for each sample is shown in the table below.

[0077] Table 1 Swimming time of mice

[0078]

[0079] The data in the table show that the swimming time of the mice in the comparative example group was longer than that of the blank control group, but shorter than that of the example group, indicating that the anti-fatigue composition of the present invention can significantly prolong the swimming time of mice. Comparing Example 3 with Comparative Examples 1-3, it can be seen that although Cistanche deserticola, Epimedium, and Cinnamon have certain anti-fatigue effects when used alone, the combined use of the three has a better anti-fatigue effect.

[0080] The tablets prepared in Example 3 were subjected to sensory evaluation for bitterness, and the evaluation indicators included:

[0081] +++ indicates that there is virtually no bitterness, or the bitterness is very barely noticeable;

[0082] ++ indicates a certain degree of bitterness, which is within an acceptable range;

[0083] + indicates a more pronounced bitter taste;

[0084] Professional test subjects were arranged to conduct the evaluation, and the results showed that 96% of the subjects chose +++, while the other 4% chose ++.

[0085] Obviously, the anti-fatigue composition of the present invention has a less pronounced bitter taste and is more suitable for a wider range of people.

[0086] The above description is merely a preferred embodiment of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions falling within the scope of the present invention's concept are within the scope of protection of the present invention. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the original intent of the present invention should also be considered within the scope of protection of the present invention.

Claims

1. An anti-fatigue composition, characterized in that, Made from the following ingredients by weight: 5-15 parts Artemisia argyi, 10-20 parts Cistanche deserticola, 5-10 parts Pueraria lobata, 5-15 parts Rehmannia glutinosa, 10-20 parts Astragalus membranaceus, 10-20 parts Epimedium brevicornu, 12-18 parts Clove, 5-15 parts Plantago asiatica, 5-12 parts Curcuma longa, 5-15 parts Cinnamomum cassia, 5-12 parts Cuscuta chinensis, and 5-12 parts Glycyrrhiza uralensis. The method for preparing the anti-fatigue composition includes the following steps: (1) After accurately weighing each raw material, grind it into powder using a pulverizer and sieve it to a fineness of 20-40 mesh to obtain medicinal powder; (2) Add the medicinal powder and extraction solvent to the extraction tank at a weight ratio of 1:(5-10), stir evenly, and soak for 100-150 minutes to obtain a mixture; (3) Heat the mixture to 50-60℃, turn on the stirring, and extract by ultrasonication for 30-45 minutes. Centrifuge for the first time to remove the residue and collect the first-stage filtrate. (4) Refrigerate the filtrate for 24 hours, centrifuge again to remove the residue, collect the secondary filtrate, concentrate under reduced pressure to obtain a thick paste, dry and pulverize the thick paste to obtain the anti-fatigue composition.

2. The anti-fatigue composition according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 7-13 parts Artemisia argyi, 13-17 parts Cistanche deserticola, 7-8 parts Pueraria lobata, 8-12 parts Rehmannia glutinosa, 13-17 parts Astragalus membranaceus, 13-17 parts Epimedium brevicornu, 14-16 parts Clove, 8-12 parts Plantago asiatica, 5-10 parts Curcuma longa, 5-12 parts Cinnamomum cassia, 5-10 parts Cuscuta chinensis, and 5-10 parts Glycyrrhiza uralensis.

3. The anti-fatigue composition according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 10 parts Artemisia argyi, 15 parts Cistanche deserticola, 8 parts Pueraria lobata, 10 parts Rehmannia glutinosa, 15 parts Astragalus membranaceus, 15 parts Epimedium brevicornu, 15 parts Clove, 10 parts Plantago asiatica, 8 parts Curcuma longa, 10 parts Cinnamomum cassia, 8 parts Cuscuta chinensis, and 8 parts Glycyrrhiza uralensis.

4. The anti-fatigue composition according to claim 1, characterized in that, The extraction solvent in step (2) is pure water.

5. The anti-fatigue composition according to claim 1, characterized in that, The refrigeration temperature in step (5) is 5-8℃.

6. A traditional Chinese medicine preparation, characterized in that, It includes the anti-fatigue composition as described in any one of claims 1-3, and pharmaceutically acceptable excipients.

7. The traditional Chinese medicine preparation according to claim 6, characterized in that, The excipients are starch and stevia.

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