A sample processing device mechanism for a fully automatic mass spectrometry detection flow pipeline

Abstract

The application discloses a kind of full-automatic sample processing equipment mechanism for mass spectrometry detection flow pipeline, comprising: base, carrier frame, carrier handling mechanism, bearing limiting mechanism, centrifugal handling mechanism.The side of base is connected with carrier frame.Carrier handling mechanism is set in the side of base close to carrier frame, and carrier handling mechanism includes handling fixed frame, the side of handling fixed frame is fixedly connected with screw rod nut, screw rod nut inner thread is connected with lifting screw rod, the top of handling fixed frame is provided with limiting support plate, and the side of limiting support plate away from handling fixed frame is connected with a pair of carrier limiting block.The application is set through carrier handling mechanism and centrifugal handling mechanism, can efficiently and accurately handle centrifugal tube, greatly reduce the fatigue caused to medical staff by repeated taking and placing centrifugal tube, avoid biological pollution between different centrifugal tubes, significantly improve the detection efficiency of sample processing equipment, and simultaneously, can be embedded with in-vitro diagnostic instrument, with strong applicability.

Description

Technical Field

[0001] This invention belongs to the field of sample processing equipment technology, specifically relating to a sample processing equipment mechanism for a fully automated mass spectrometry detection pipeline. Background Technology

[0002] Mass spectrometry is a technique for identifying compounds by preparing, separating, and detecting gaseous ions. It plays a very important role in the identification of organic molecules. A fully automated mass spectrometry detection line is an automated mass spectrometry detection device composed of sample processing equipment, ion source, mass analyzer, detector, and data processing system. It has the advantages of high detection accuracy and high detection efficiency.

[0003] Among them, sample processing equipment is a type of equipment used for qualitative or quantitative analysis of patients' body fluid samples (sputum, blood, urine). It is mainly used for adding internal standard solutions, pipetting, blowing sputum, and mixing. When using sample processing equipment, the centrifuge tube carrier or 96-well plate after pipetting needs to be shaken and mixed and incubated with heat to facilitate a full and effective reaction between the sample and reagents.

[0004] Since the same sample cup needs to be centrifuged multiple times during sample processing, the existing technology mainly uses manual mixing to mix the samples. Manual mixing is not only time-consuming and labor-intensive, but also prone to errors in mixing speed and temperature, which prevents the samples and reagents from effectively separating into layers. This affects the accuracy of the test results and reduces the effectiveness of the sample processing equipment.

[0005] Therefore, in order to address the above-mentioned technical problems, it is necessary to provide a sample processing device mechanism for a fully automated mass spectrometry detection pipeline. Summary of the Invention

[0006] The purpose of this invention is to provide a sample processing device mechanism for a fully automated mass spectrometry detection line, so as to solve the problem that the above-mentioned sample processing devices have poor sample processing effect.

[0007] To achieve the above objectives, an embodiment of the present invention provides the following technical solution:

[0008] A sample processing device mechanism for a fully automated mass spectrometry detection line includes: a base, a carrier frame, a carrier transport mechanism, a load-bearing limiting mechanism, and a centrifugal transport mechanism.

[0009] A vehicle frame is connected to one side of the base.

[0010] The vehicle transport mechanism is located on the side of the base close to the vehicle frame. The vehicle transport mechanism includes a transport fixing frame. A lead screw nut is fixedly connected to one side of the transport fixing frame. A lifting lead screw is internally threaded into the lead screw nut. A limiting support plate is provided above the transport fixing frame. A pair of vehicle limiting blocks are connected to the side of the limiting support plate away from the transport fixing frame. A transport platform is provided between the pair of vehicle limiting blocks. The transport platform is slidably connected to the limiting support plate. A linkage fixing block is fixedly connected above the transport platform. A swing arm is slidably connected to the linkage fixing block. A swing motor is drivenly connected to the end of the swing arm away from the linkage fixing block.

[0011] The load-bearing limiting mechanism is located on the side of the transport fixing frame away from the carrier frame. The load-bearing limiting mechanism includes a carrier limiting frame, which is used to support various workstation carriers.

[0012] The centrifugal transport mechanism is located on the side of the carrier limiting frame away from the transport fixing frame. The centrifugal transport mechanism includes a centrifugal transport frame, an assembly support frame below the centrifugal transport frame, a negative pressure limiting frame on the side of the assembly support frame close to the carrier limiting frame, and multiple evenly distributed transport nozzles connected below the negative pressure limiting frame. A pipetting transport frame is located on the side of the centrifugal transport frame away from the carrier limiting frame, a fixed support plate is located below the pipetting transport frame, and a suction pen is located on the side of the fixed support plate away from the centrifugal transport frame.

[0013] Furthermore, a screw fixing frame is rotatably connected to the outer side of the lifting screw, and the transport fixing frame is slidably connected to the screw fixing frame. The screw fixing frame supports and fixes the lifting screw. Simultaneously, the screw fixing frame guides the movement of the transport fixing frame. A lifting motor is connected to one side of the screw fixing frame. The lifting motor provides power, driving the lifting screw to rotate by controlling its operation. A first transmission wheel is connected to the output shaft of the screw fixing frame, and a second transmission wheel is connected to the end of the lifting screw located outside the screw fixing frame. A transmission toothed belt connects the first and second transmission wheels. The interaction of the first and second transmission wheels and the transmission toothed belt provides a transmission connection between the lifting screw and the output shaft of the lifting motor.

[0014] Furthermore, a translational fixing plate is fixedly connected to the lower part of the lead screw fixing frame. The translational fixing plate supports and fixes the lead screw fixing frame. A translational limiting seat is provided below the translational fixing plate, and the translational fixing plate is slidably connected to the translational limiting seat. The translational limiting seat supports and guides the movement of the translational fixing plate. A translational lead screw is rotatably connected inside the translational limiting seat, and the translational fixing plate is threadedly connected to the translational lead screw. By controlling the rotation of the translational lead screw, the translational limiting seat rotates with the rotation of the translational lead screw under the action of the internal and external threads, thereby facilitating the movement control of the translational fixing plate. A third transmission wheel is connected to one end of the translational lead screw located on the translational fixing plate. The third transmission wheel drives the rotation of the translational lead screw.

[0015] A fourth transmission wheel is provided on one side of the third transmission wheel. The fourth transmission wheel serves to transmit power to the translation motor. A toothed belt connects the fourth transmission wheel to the third transmission wheel, and the translation motor is driven to one side of the fourth transmission wheel. This facilitates the rotational drive of the fourth transmission wheel by controlling the operation of the translation motor, thereby facilitating the rotational drive of the translation screw.

[0016] Furthermore, a pair of clearance slots are provided within the linkage fixing block. These slots provide installation space for the connecting springs and also guide the movement of the lifting motor. Each pair of clearance slots contains a connecting spring, one end of which is fixedly connected to the transport platform. The connecting springs act as a limiting element in the connection between the rotating ejector and the transport platform.

[0017] The other end of the connecting spring is connected to a rotating ejector. This facilitates the lifting of the sampling tray stored on the transport platform by rotating the ejector. Ejection pulleys are connected to both sides of the rotating ejector. The rolling of the ejection pulleys improves the smoothness of lifting the sampling tray. A limit slider is rotatably connected to the bottom of the rotating ejector, and the limit slider is fixedly connected to a limit support plate. This allows the limit slider to support and limit the rotating ejector. A movable slide rail is slidably connected to the limit slider, and the movable slide rail is fixedly connected to the transport platform. The movable slide rail guides the movement of the limit slider.

[0018] Furthermore, the carrier limiting frame is equipped with a pair of centrifuge tube carriers. The pair of centrifuge tube carriers serve to support and limit the centrifuge tubes. A 96-hole plate is provided on the side of the centrifuge tube carrier close to the transport fixing frame, a nozzle carrier is provided on the side of the 96-hole plate away from the centrifuge tube carrier, and a transfer carrier is provided on the side of the centrifuge tube carrier away from the transport fixing frame.

[0019] Furthermore, both the centrifuge transport rack and the pipette transport rack are equipped with electrically driven translation cylinders above them, and both are slidably connected to these cylinders. This facilitates the support, limiting, and horizontal movement of the centrifuge transport rack and the pipette transport rack via the electrically driven translation cylinders. Electrically driven lifting screws connect the centrifuge transport rack and the assembly support frame, as well as the pipette transport rack and the fixed support plate. These screws provide connection, limiting, and vertical lifting movement for the centrifuge transport rack and the assembly support frame, and the pipette transport rack and the fixed support plate.

[0020] Furthermore, an electric lifting rod connects the negative pressure limiting frame to the assembly support frame. The negative pressure limiting frame is equipped with multiple evenly distributed vacuum valves, all of which are connected to the transport suction nozzle. This facilitates the generation of a transport negative pressure by the vacuum valves.

[0021] Furthermore, a pen-drawing rotating shaft is fixedly connected to the pen. The pen-drawing rotating shaft supports and fixes the pen and drives its rotation. One end of the pen-drawing rotating shaft is connected to a fifth transmission wheel. The fifth transmission wheel drives the pen-drawing rotating shaft. A rotary motor is located above the fifth transmission wheel. The rotary motor provides power, facilitating the rotation of a sixth transmission wheel by controlling its operation. The output end of the rotary motor is connected to the sixth transmission wheel, and a synchronous toothed belt connects the rotary motor and the sixth transmission wheel.

[0022] Furthermore, a first sliding fixing plate is fixedly connected to the side of the rotary motor close to the second sliding fixing plate. The first sliding fixing plate supports and fixes the rotary motor. A second sliding fixing plate is provided between the first sliding fixing plate and the fixed support plate, and an electric lifting rod is connected between the sixth transmission wheel, the first sliding fixing plate, and the second sliding fixing plate. The electric lifting rod connects, limits, and moves the sixth transmission wheel, the first sliding fixing plate, and the second sliding fixing plate.

[0023] Furthermore, a gripper transport mechanism is connected to the side of the assembly support frame that is close to the fixed support plate. The gripper transport mechanism clamps and transports the centrifuge tubes. The gripper transport mechanism includes a gripper fixing plate, which supports and fixes the gripper screw. The gripper screw is rotatably connected to the lower part of the gripper fixing plate. The gripper screw controls the movement of the transport grippers. A pair of transport grippers are threaded onto the outer side of the gripper screw, and the inner threads of the pair of transport grippers are in opposite directions. This allows the pair of transport grippers to move in opposite directions under the action of the inner and outer threads, thus facilitating the clamping and transport of the centrifuge tubes.

[0024] Compared with the prior art, the present invention has the following advantages:

[0025] This invention, through the design of a carrier transport mechanism and a centrifuge transport mechanism, enables efficient and accurate transport of centrifuge tubes, greatly reducing the fatigue caused to medical staff by repeatedly picking up and putting down centrifuge tubes, avoiding biological contamination between different centrifuge tubes, significantly improving the detection efficiency of sample processing equipment, and can also be integrated with in vitro diagnostic instruments, making it highly applicable. Attached Figure Description

[0026] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0027] Figure 1 This is a perspective view of a sample processing device mechanism for a fully automated mass spectrometry detection pipeline according to an embodiment of the present invention;

[0028] Figure 2 This is a top view schematic diagram of a sample processing device mechanism for a fully automated mass spectrometry detection pipeline according to an embodiment of the present invention;

[0029] Figure 3 This is a perspective view of a vehicle transport mechanism according to an embodiment of the present invention;

[0030] Figure 4 for Figure 3 Schematic diagram of the structure at point A in the middle;

[0031] Figure 5 This is a front view of a vehicle transport mechanism according to an embodiment of the present invention;

[0032] Figure 6 for Figure 5 Schematic diagram of the structure at point B;

[0033] Figure 7 This is a partial structural schematic diagram of a vehicle handling mechanism in one embodiment of the present invention;

[0034] Figure 8 This is a first perspective view of a centrifugal conveying mechanism according to an embodiment of the present invention;

[0035] Figure 9 This is a second perspective view of the centrifugal conveying mechanism in one embodiment of the present invention;

[0036] Figure 10 for Figure 9 Schematic diagram of the structure at point C;

[0037] Figure 11 for Figure 9Schematic diagram of the structure at position D in;

[0038] Figure 12 is a third perspective view of the centrifugal transfer mechanism in an embodiment of the present invention;

[0039] Figure 13 is Figure 12 Schematic diagram of the structure at position E in;

[0040] Figure 14 is a schematic diagram of the bearing limit mechanism in an embodiment of the present invention.

[0041] In the figure: 1. Base, 101. Carrier frame, 2. Carrier transfer mechanism, 201. Transfer fixing frame, 202. Screw nut, 203. Lifting screw, 204. Limit support plate, 205. Carrier limit block, 206. Transfer platform, 207. Linkage fixing block, 208. Swing arm, 209. Swing motor, 210. Screw fixing frame, 211. Lifting motor, 212. First transmission wheel, 213. Second transmission wheel, 214. Translation fixing plate, 215. Translation limit seat, 216. Translation screw, 217. Third transmission wheel, 218. Fourth transmission wheel, 219. Translation motor, 220. Connecting spring, 221. Rotating ejection member, 222. Ejection pulley, 223. Limit slider, 224. Moving slide rail, 3. Bearing limit mechanism, 301. Carrier limit frame, 302. Centrifuge tube carrier, 303. 96-well plate, 304. Tip carrier, 305. Transfer carrier, 4. Centrifugal transfer mechanism, 401. Centrifugal transfer frame, 402. Assembly support frame, 403. Negative pressure limit frame, 404. Transfer suction nozzle, 405. Pipetting transfer frame, 406. Fixing support plate, 407. Suction pen, 408. Electric translation screw cylinder, 409. Electric lifting screw, 410. Vacuum valve, 411. Suction pen rotating shaft, 412. Fifth transmission wheel, 413. Rotating motor, 414. Sixth transmission wheel, 415. First sliding fixing plate, 416. Second sliding fixing plate, 417. Claw fixing plate, 418. Claw screw, 419. Transfer claw. Detailed Description of the Embodiments

[0042] Hereinafter, the present invention will be described in detail with reference to the embodiments shown in the accompanying drawings. However, these embodiments do not limit the present invention, and any changes in structure, method, or function made by those of ordinary skill in the art based on these embodiments are included in the protection scope of the present invention.

[0043] The invention discloses a wear-resistant seal member for a valve stem, refer to Figures 1-14 as shown, comprising: a base 1, a carrier frame 101, a carrier transfer mechanism 2, a bearing limit mechanism 3, and a centrifugal transfer mechanism 4.

[0044] refer to Figure 1As shown, one side of the base 1 is connected with a carrier holder 101, which facilitates carrying and limiting the carrier through the carrier holder 101.

[0045] Refer to Figures 1-4 As shown, the carrier conveying mechanism 2 is disposed on a side of the base 1 close to the carrier holder 101, which facilitates conveying the carrier stored on the carrier holder 101 through the carrier conveying mechanism 2. The carrier conveying mechanism 2 includes a conveying fixing frame 201, and the conveying fixing frame 201 performs supporting, limiting and movement control on a limiting support plate 204.

[0046] Refer to Figures 3-4 As shown, one side of the conveying fixing frame 201 is fixedly connected with a screw nut 202. The screw nut 202 supports and fixes the conveying fixing frame 201, and meanwhile, facilitates lifting control of the conveying fixing frame 201 by means of lifting control of the screw nut 202. A lifting screw 203 is in threaded connection inside the screw nut 202, and the lifting screw 203 performs supporting, limiting and lifting control on the screw nut 202.

[0047] Refer to Figures 3-6 As shown, the outer side of the lifting screw 203 is rotatably connected with a screw fixing frame 210, and the conveying fixing frame 201 is in sliding connection with the screw fixing frame 210. The screw fixing frame 210 supports and fixes the lifting screw 203, and meanwhile performs movement guiding on the conveying fixing frame 201.

[0048] Refer to Figures 3-6 As shown, one side of the screw fixing frame 210 is connected with a lifting motor 211. The lifting motor 211 provides power, and rotation driving of the lifting screw 203 is implemented by controlling the operation of the lifting motor 211. A first transmission wheel 212 is connected to an output shaft of the lifting motor 211, an end of the lifting screw 203 located outside the screw fixing frame 210 is connected with a second transmission wheel 213, and a transmission toothed belt is connected between the first transmission wheel 212 and the second transmission wheel 213. Through mutual cooperation of the first transmission wheel 212, the second transmission wheel 213 and the transmission toothed belt, transmission connection between the lifting screw 203 and the output shaft of the lifting motor 211 is implemented.

[0049] Refer to Figures 3-6 As shown, a translation fixing plate 214 is fixedly connected below the screw fixing frame 210. The translation fixing plate 214 supports and fixes the screw fixing frame 210. A translation limiting seat 215 is disposed below the translation fixing plate 214, the translation fixing plate 214 is in sliding connection with the translation limiting seat 215, and the translation limiting seat 215 supports and performs movement guiding on the translation fixing plate 214.

[0050] Refer to Figures 3-6As shown, a translation screw 216 is rotatably connected in a translation limit seat 215, and a translation fixing plate 214 is threadedly connected with the translation screw 216. By controlling the rotation of the translation screw 216, the translation limit seat 215 rotates along with the rotation of the translation screw 216 under the action of internal and external threads, thereby facilitating the movement control of the translation fixing plate 214.

[0051] Referring to Figures 3-6 As shown, the translation screw 216 is connected with a third transmission wheel 217 at one end located at the translation fixing plate 214. The third transmission wheel 217 performs a rotation driving function on the translation screw 216. A fourth transmission wheel 218 is provided on one side of the third transmission wheel 217. The fourth transmission wheel 218 functions to transmit power from a translation motor 219. A transmission toothed belt is connected between the fourth transmission wheel 218 and the third transmission wheel 217, and a translation motor 219 is drivingly connected to one side of the fourth transmission wheel 218. It is convenient to rotationally drive the fourth transmission wheel 218 by controlling the operation of the translation motor 219, thereby facilitating rotational driving of the translation screw 216.

[0052] Referring to Figures 3-4 As shown, a limit support plate 204 is provided above a conveying fixing frame 201. The limit support plate 204 performs a supporting and fixing function on carrier limit blocks 205. A rotary connecting block is connected between the conveying fixing frame 201 and the limit support plate 204, which facilitates rotation of the limit support plate 204 by controlling the rotation of the rotary connecting block, thereby facilitating conveyance of carriers stored on a carrier frame 101 onto a carrier limit frame 301 by means of rotation.

[0053] Referring to Figures 3-4 As shown, a pair of carrier limit blocks 205 is connected to a side of the limit support plate 204 away from the conveying fixing frame 201. The pair of carrier limit blocks 205 performs a conveying limit function on a carrier placed on the limit support plate 204. A conveying platform 206 is provided between the pair of carrier limit blocks 205, the conveying platform 206 is slidably connected with the limit support plate 204, and the conveying platform 206 performs a supporting and limiting function on the carrier.

[0054] Referring to Figures 3-4 As shown, a linkage fixing block 207 is fixedly connected above the conveying platform 206. The linkage fixing block 207 performs a supporting, fixing and movement control function on the conveying platform 206. A swing arm 208 is slidably connected to the linkage fixing block 207. The swing arm 208 functions to connect the linkage fixing block 207 and a swing motor 209, which enables the linkage fixing block 207 to move along with the swinging of the swing motor 209 under the action of the swing arm 208. A swing motor 209 is drivingly connected to an end of the swing arm 208 away from the linkage fixing block 207. The swing arm 208 is driven and controlled by controlling the operation of the swing motor 209.

[0055] Specifically, a pair of avoiding grooves is formed in the linkage fixing block 207. The arrangement of the avoiding grooves provides an installation and assembly space for the connecting spring 220, and meanwhile plays a role in movement guiding for the lifting motor 211.

[0056] Refer to Figures 3-4 as shown in the figure, the connecting spring 220 is disposed in each of the pair of avoiding grooves, and one end of the connecting spring 220 is fixedly connected with the conveying platform 206. The connecting spring 220 plays a role in connection and position limiting for the rotary ejection member 221 and the conveying platform 206. The other end of the connecting spring 220 is connected with the rotary ejection member 221, which facilitates ejecting the sampling disc stored on the conveying platform 206 through rotation of the rotary ejection member 221.

[0057] Refer to Figures 3-7 as shown in the figure, ejection pulleys 222 are connected to both sides of the rotary ejection member 221. Through rolling of the ejection pulleys 222, the fluency of ejecting the sampling disc by the rotary ejection member 221 is improved. A position limiting slider 223 is rotatably connected below the rotary ejection member 221, and the position limiting slider 223 is fixedly connected with a position limiting support plate 204, which facilitates supporting and position limiting the rotary ejection member 221 through the position limiting slider 223. A moving slide rail 224 is slidably connected onto the position limiting slider 223, and the moving slide rail 224 is fixedly connected with the conveying platform 206. The moving slide rail 224 plays a role in movement guiding for the position limiting slider 223.

[0058] Refer to Figure 14 as shown in the figure, the carrying and limiting mechanism 3 is disposed on a side of the conveying fixing frame 201 away from the carrier frame 101, the carrying and limiting mechanism 3 comprises a carrier limiting frame 301, and the carrier limiting frame 301 is configured to carry a plurality of station carriers.

[0059] Refer to Figure 14 as shown in the figure, a pair of centrifuge tube carriers 302 is disposed on the carrier limiting frame 301. The pair of centrifuge tube carriers 302 plays a role in carrying and position limiting for centrifuge tubes. A 96-well plate 303 is disposed on a side of the centrifuge tube carrier 302 close to the conveying fixing frame 201, a pipette tip carrier 304 is disposed on a side of the 96-well plate 303 away from the centrifuge tube carrier 302, and a transfer carrier 305 is disposed on a side of the centrifuge tube carrier 302 away from the conveying fixing frame 201.

[0060] Refer to Figures 8-13 as shown in the figure, the centrifugal conveying mechanism 4 is disposed on a side of the carrier limiting frame 301 away from the conveying fixing frame 201. The centrifugal conveying mechanism 4 is configured to convey the centrifuge tubes placed on the carrier limiting frame 301. The centrifugal conveying mechanism 4 comprises a centrifugal conveying frame 401, and the centrifugal conveying frame 401 plays a role in supporting and fixing a negative pressure limiting frame 403 and a clamping jaw fixing plate 417.

[0061] Refer to Figures 8-11As shown, an assembly support frame 402 is arranged below the centrifugal transfer frame 401. The assembly support frame 402 supports and fixes the negative pressure limiting frame 403. The negative pressure limiting frame 403 is arranged on a side of the assembly support frame 402 close to the carrier limiting frame 301, which facilitates assembly and fixation of a plurality of transfer suction nozzles 404 through the negative pressure limiting frame 403.

[0062] Reference Figures 8-11 As shown, a plurality of uniformly distributed transfer suction nozzles 404 are connected below the negative pressure limiting frame 403, which facilitates negative pressure adsorption and transfer of centrifugal tubes through the plurality of transfer suction nozzles 404.

[0063] Reference Figures 8-13 As shown, a pipetting transfer frame 405 is arranged on a side of the centrifugal transfer frame 401 away from the carrier limiting frame 301. The pipetting transfer frame 405 performs assembly and limiting on a fixed support plate 406. The fixed support plate 406 is arranged below the pipetting transfer frame 405. The fixed support plate 406 performs assembly and limiting on a second sliding fixing plate 416. A suction pen 407 is arranged on a side of the fixed support plate 406 away from the centrifugal transfer frame 401, which facilitates pipetting of liquid in centrifugal tubes through the suction pen 407.

[0064] Reference Figures 8-11 As shown, electric translation screw cylinders 408 are respectively arranged above the centrifugal transfer frame 401 and the pipetting transfer frame 405, and both the centrifugal transfer frame 401 and the pipetting transfer frame 405 are slidably connected to the electric translation screw cylinders 408, which facilitates supporting, limiting and horizontal movement of the centrifugal transfer frame 401 and the pipetting transfer frame 405 through the electric translation screw cylinders 408.

[0065] Reference Figures 8-11 As shown, electric lifting lead screws 409 are connected between the centrifugal transfer frame 401 and the assembly support frame 402, and between the pipetting transfer frame 405 and the fixed support plate 406 respectively. Connection, limiting and vertical lifting movement of the centrifugal transfer frame 401 and the assembly support frame 402, and of the pipetting transfer frame 405 and the fixed support plate 406 are achieved through the electric lifting lead screws 409.

[0066] Reference Figures 8-11 As shown, an electric lifting rod is connected between the negative pressure limiting frame 403 and the assembly support frame 402. A plurality of uniformly distributed vacuum valves 410 are arranged in the negative pressure limiting frame 403, and the plurality of vacuum valves 410 are all in communication with the transfer suction nozzles 404, which facilitates enabling the negative pressure limiting frame 403 to generate transfer negative pressure through the vacuum valves 410.

[0067] Reference Figures 8-11As shown, a suction pen rotating shaft 411 is fixedly connected to the suction pen 407. The suction pen rotating shaft 411 functions to support, fix and rotationally drive the suction pen 407. One end of the suction pen rotating shaft 411 is connected with a fifth transmission wheel 412. The fifth transmission wheel 412 rotationally drives the suction pen rotating shaft 411. A rotation motor 413 is arranged above the fifth transmission wheel 412. The rotation motor functions to provide power, which facilitates rotationally driving a sixth transmission wheel 414 by controlling the operation of the rotation motor 413. The output end of the rotation motor 413 is connected with the sixth transmission wheel 414, and a synchronous toothed belt is connected between the rotation motor 413 and the sixth transmission wheel 414.

[0068] Refer Figures 8-11 As shown, a first sliding fixing plate 415 is fixedly connected to the side of the rotation motor 413 that is close to a second sliding fixing plate 416. The first sliding fixing plate 415 functions to support and fix the rotation motor 413. The second sliding fixing plate 416 is arranged between the first sliding fixing plate 415 and a fixed support plate 406, and electric lifting rods are respectively connected between the sixth transmission wheel 414, between the first sliding fixing plate 415 and the second sliding fixing plate 416. The electric lifting rods function to connect, limit and drive the sixth transmission wheel 414, the first sliding fixing plate 415 and the second sliding fixing plate 416 to move up and down.

[0069] Refer Figures 12-13 As shown, a gripper conveying mechanism is connected to each side of an assembly support frame 402 and the fixed support plate 406 that are close to each other. The gripper conveying mechanism functions to clamp and convey centrifuge tubes. The gripper conveying mechanism comprises a gripper fixing plate 417. The gripper fixing plate 417 functions to support and fix a gripper lead screw 418. A gripper lead screw 418 is rotatably connected below the gripper fixing plate 417. The gripper lead screw 418 functions to control the movement of conveying grippers 419.

[0070] Refer Figures 12-13 As shown, a pair of conveying grippers 419 are in threaded connection with the outer side of the gripper lead screw 418, and the internal threads of the pair of conveying grippers 419 have opposite directions. This arrangement facilitates the pair of conveying grippers 419 to move in opposite directions under the action of the internal and external threads, so that the centrifuge tube can be clamped and conveyed by the pair of conveying grippers 419 conveniently.

[0071] In practical use, the translation motor 219 is controlled to rotate the translation screw 216, and the screw fixing frame 210 moves horizontally under the cooperation of the translation fixing plate 214 and the translation limit seat 215. The lifting motor 211 is controlled to lift the transport fixing frame 201. When it is necessary to transport the vehicle stored on the vehicle rack 101, the lifting motor 211 is controlled to move the transport fixing frame 201 to a certain height. Then, the limit support plate 204 is rotated to align with the vehicle rack 101. Subsequently, the lifting motor 211 and the translation motor 219 control the limit support plate 204 to move horizontally and vertically to carry and transport the vehicle on the vehicle rack 101.

[0072] When the carrier moves to the transport position of the carrier limit frame 301 under the action of the limit support plate 204, the operation of the swing motor 209 is controlled to cause the linkage fixing block 207 to move along with the swing arm 208 and the transport platform 206. The carrier on the transport platform 206 is moved by the horizontal movement of the transport platform 206 and the linkage fixing block 207. During the movement of the transport platform 206, the rotating ejector 221 is ejected along with the movement of the transport platform 206 under the cooperation of the connecting spring 220, the limit slider 223 and the moving slide rail 224. The ejection of the rotating ejector 221 lifts the carrier on the transport platform 206, making it easier to transport the carrier.

[0073] When centrifuge tubes on the carrier limiting frame 301 need to be moved, the operation of the electric translation screw cylinder 408 is controlled to move the centrifuge transport frame 401 and the pipetting transport frame 405 horizontally. At the same time, the operation of the electric lifting screw 409 is used to control the horizontal movement of the centrifuge transport frame 401 and the pipetting transport frame 405 respectively. The centrifuge tubes on the carrier limiting frame 301 are transported by negative pressure adsorption through the transport nozzle 404. The centrifuge tubes can be pipetted by moving the suction pen 407.

[0074] In addition, centrifuge tubes on the carrier limit frame 301 can be clamped and transported by a pair of transport grippers 419, which reduces the fatigue caused to medical staff by repeatedly picking up and putting down centrifuge tubes and avoids biological contamination between different centrifuge tubes.

[0075] As can be seen from the above technical solutions, the present invention has the following beneficial effects:

[0076] This invention, through the design of a carrier transport mechanism and a centrifuge transport mechanism, enables efficient and accurate transport of centrifuge tubes, greatly reducing the fatigue caused to medical staff by repeatedly picking up and putting down centrifuge tubes, avoiding biological contamination between different centrifuge tubes, significantly improving the detection efficiency of sample processing equipment, and can also be integrated with in vitro diagnostic instruments, making it highly applicable.

[0077] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.

[0078] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style of the specification is merely for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A sample processing device mechanism for a fully automated mass spectrometry detection line, characterized in that, include: A base, one side of which is connected to a vehicle frame; A vehicle transport mechanism is located on the side of the base close to the vehicle frame. The vehicle transport mechanism includes a transport fixing frame. A screw nut is fixedly connected to one side of the transport fixing frame. A lifting screw is internally threaded into the screw nut. A limiting support plate is provided above the transport fixing frame. A pair of vehicle limiting blocks are connected to the side of the limiting support plate away from the transport fixing frame. A transport platform is provided between the pair of vehicle limiting blocks. The transport platform is slidably connected to the limiting support plate. A linkage fixing block is fixedly connected above the transport platform. A swing arm is slidably connected to the linkage fixing block. A swing motor is drivenly connected to the end of the swing arm away from the linkage fixing block. The linkage fixing block has a pair of clearance slots, and each of the clearance slots is equipped with a connecting spring. One end of the connecting spring is fixedly connected to the transport platform, and the other end of the connecting spring is connected to a rotating ejector. Both sides of the rotating ejector are connected to ejector pulleys. A limit slider is rotatably connected to the bottom of the rotating ejector. The limit slider is fixedly connected to a limit support plate. A movable slide rail is slidably connected to the limit slider, and the movable slide rail is fixedly connected to the transport platform. A load-bearing limiting mechanism is provided on the side of the transport fixing frame away from the carrier frame. The load-bearing limiting mechanism includes a carrier limiting frame, which is used to support various workstation carriers. A centrifugal transport mechanism is located on the side of the carrier limiting frame away from the transport fixing frame. The centrifugal transport mechanism includes a centrifugal transport frame, an assembly support frame below the centrifugal transport frame, a negative pressure limiting frame on the side of the assembly support frame close to the carrier limiting frame, and multiple evenly distributed transport nozzles connected below the negative pressure limiting frame. A pipetting transport frame is located on the side of the centrifugal transport frame away from the carrier limiting frame, a fixing support plate is located below the pipetting transport frame, and a suction pen is located on the side of the fixing support plate away from the centrifugal transport frame.

2. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 1, characterized in that, A rotating adapter block is connected between the transport fixing frame and the limiting support plate. A screw fixing frame is rotatably connected to the outside of the lifting screw. The transport fixing frame and the screw fixing frame are slidably connected. A lifting motor is connected to one side of the screw fixing frame. A first transmission wheel is connected to the output shaft of the screw fixing frame. A second transmission wheel is connected to the end of the lifting screw located outside the screw fixing frame. A transmission toothed belt is connected between the first transmission wheel and the second transmission wheel.

3. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 2, characterized in that, A translational fixing plate is fixedly connected to the lower part of the lead screw fixing frame. A translational limiting seat is provided below the translational fixing plate. The translational fixing plate and the translational limiting seat are slidably connected. A translational lead screw is rotatably connected inside the translational limiting seat. The translational fixing plate and the translational lead screw are threadedly connected. A third transmission wheel is connected to one end of the translational lead screw located on the translational fixing plate. A fourth transmission wheel is provided on one side of the third transmission wheel. A transmission toothed belt is connected between the fourth transmission wheel and the third transmission wheel. A translational motor is drivenly connected to one side of the fourth transmission wheel.

4. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 1, characterized in that, The carrier limiting frame is equipped with a pair of centrifuge tube carriers. A 96-hole plate is provided on the side of the centrifuge tube carrier close to the transport fixing frame. A gun head carrier is provided on the side of the 96-hole plate away from the centrifuge tube carrier. A transfer carrier is provided on the side of the centrifuge tube carrier away from the transport fixing frame.

5. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 1, characterized in that, Both the centrifuge transport rack and the pipetting transport rack are equipped with an electric translation screw cylinder. Both the centrifuge transport rack and the pipetting transport rack are slidably connected to the electric translation screw cylinder. Electric lifting screws are connected between the centrifuge transport rack and the assembly support frame, and between the pipetting transport rack and the fixed support plate.

6. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 5, characterized in that, An electric lifting rod is connected between the negative pressure limiting frame and the assembly support frame. The negative pressure limiting frame is equipped with multiple evenly distributed vacuum valves, all of which are connected to the transport suction nozzle.

7. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 1, characterized in that, The pen is fixedly connected to a pen-absorbing rotating shaft. One end of the pen-absorbing rotating shaft is connected to a fifth transmission wheel. A rotary motor is provided above the fifth transmission wheel. The output end of the rotary motor is connected to a sixth transmission wheel. A synchronous toothed belt is connected between the rotary motor and the sixth transmission wheel.

8. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 7, characterized in that, The first sliding fixing plate is fixedly connected to the side of the rotary motor close to the second sliding fixing plate. The second sliding fixing plate is provided between the first sliding fixing plate and the fixed support plate. An electric lifting rod is connected between the sixth transmission wheel, the first sliding fixing plate and the second sliding fixing plate.

9. The sample processing equipment mechanism for a fully automated mass spectrometry detection line according to claim 1, characterized in that, The assembly support frame is connected to a gripper transport mechanism on the side that is close to the fixed support plate. The gripper transport mechanism includes a gripper fixing plate, and a gripper screw is rotatably connected to the lower part of the gripper fixing plate. A pair of transport grippers are threaded to the outer side of the gripper screw, and the inner threads of the pair of transport grippers are in opposite directions.

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