A special EVC cage for establishing SPF level mouse closed colony animal model

Abstract

The application discloses a special EVC cage for establishing an SPF level mouse closed colony animal model, which comprises an EVC cage body and a cage cover, a main body partition plate is inserted on the EVC cage body, and a partition plate clamping plate is elastically connected to the outer side wall of the EVC cage body, the main body partition plate is fixed on the EVC cage body through the partition plate clamping plate, a bedding trough is connected to the bottom of the EVC cage body, bedding trough side wall baffles are embedded on the front and rear side walls of the bedding trough, and a bedding trough partition plate which can be turned over is connected in the bedding trough. The main body partition plate can separate the EVC cage body, so that the influence of cage separation on pregnant female mice is reduced to the maximum, the possibility of postpartum eating of the female mice is reduced due to the shock of the pregnant female mice, and the bedding trough partition plate can separate the bedding with different female mouse odors, so as to prepare for the milk feeding of the baby mice.

Description

TECHNICAL FIELD

[0001] The application relates to an EVC cage, in particular to an SPF-level mouse closed colony animal model establishment special EVC cage, and belongs to the field of application of experimental animal model establishment special equipment. BACKGROUND

[0002] Experimental mice are widely used in the research of sleep, memory, biological rhythm and the like, and are natural hosts of hantavirus, forest encephalitis virus, pramal virus and other human-animal shared disease pathogens. Cultivation of an SPF-level mouse closed colony animal model can improve the utilization level and service capability of experimental animal resources from the source, and provide strong support for the development of the biological medicine industry.

[0003] According to the national standard, SPF-level mice should be bred in a barrier facility, and the technical indexes such as temperature, relative humidity, air exchange frequency, air cleanliness, bacterial colony number, pressure difference, noise and the like in the barrier facility and the breeding cage are required. At present, commonly used mouse breeding cages have two kinds, namely, an open flat shelf (with a room as an independent unit) and a closed cage (with an independent cage box as a breeding unit). Among them, the closed cage has a central exhaust ventilation cage system (Exhaust Ventilation central Cages, referred to as EVC) and an independent ventilation cage system (Individual Ventilated Cages, referred to as IVC).

[0004] The fan at the top end of the EVC host discharges the exhaust gas in the cage box from the exhaust port through the filter, connects the rack exhaust duct with the central exhaust ventilation system in the barrier environment to exhaust air, and sends clean air into each cage box after filtering from the air inlet of the breeding cage. And the breeding cage forms a micro-negative pressure, is independent of each other and has no cross contamination, and can be suitable for breeding SPF-level experimental animals. Compared with the static (open) cage, the EVC (i.e. exhaust ventilation) system inherits the advantages of the IVC, the cages are independent of each other, cross infection is prevented, and the harm of allergic substances and serious odor generated by experimental animals to experimental personnel is avoided. Therefore, the EVC cage has been widely concerned and used by major research institutions and biological medicine companies since it was put on the market.

[0005] The breeding of genetically engineered mice is a very important link in animal experiments, especially for multi-gene modified mice. However, during the breeding process of mice, the mother mice often eat the baby mice, which leads to the death of the genetically modified mice that are difficult to cultivate. In order to avoid this situation, the method of separating cages and feeding baby mice with milk can be used during the breeding process of mice. However, since the existing EVC cage is single, the pregnant mother mouse needs to be transferred to another cage during the separation of cages, so that the movement and noise generated during the separation of cages may cause the pregnant mother mouse to be frightened and increase the possibility of eating the baby after giving birth. In addition, if the baby mouse needs to be fed with milk, the milk-fed baby mouse needs to be in contact with the smell of the lactating mother mouse, such as contacting the bedding of the mother mouse before lactation. However, the bottom of the existing EVC cage is a sealed structure, so if the bedding with the smell of the lactating mother mouse is needed, the bedding can only be taken from the top of the cage. The movement and noise generated during the process of taking the bedding may also frighten the lactating mother mouse and increase the possibility of eating the baby after giving birth.

[0006] Therefore, there is an urgent need to develop an EVC cage that can isolate pregnant mother mice in a quiet state and obtain bedding with the smell of lactating mother mice without affecting lactating mother mice. SUMMARY

[0007] The purpose of the present application is to develop an EVC cage that can isolate pregnant mother mice in a quiet state and obtain bedding with the smell of lactating mother mice without affecting lactating mother mice, specifically to provide a special EVC cage for establishing an SPF level mouse closed colony animal model.

[0008] The present application realizes the above-mentioned purpose through the following technical scheme, a special EVC cage for establishing an SPF level mouse closed colony animal model, comprising an EVC cage body and a cage cover, a water bottle placing groove is arranged on the right side of the inside of the EVC cage body, a feed trough is arranged on the left side of the inside of the EVC cage body, a water bottle is placed on the water bottle placing groove, a main body partition plate is inserted into the EVC cage body, and a partition plate clamping plate is elastically connected to the outer wall of the EVC cage body, the main body partition plate is fixed to the EVC cage body through the partition plate clamping plate, a water dispenser I and a water dispenser II that can be turned up and down are installed on the water bottle placing groove, the water bottle is in communication with the water dispenser I and the water dispenser II respectively, a water dispenser II valve is installed on the water bottle placing groove,

[0009] The EVC cage body is of an open bottom structure, and a plurality of horizontal bars are installed at the bottom of the EVC cage body.

[0010] A bedding trough is connected to the bottom of the EVC cage body, bedding trough side wall baffles are embedded on the front and rear side walls of the bedding trough, and a bedding trough partition plate that can be turned over is connected in the bedding trough.

[0011] Preferably, a pair of limiting block clamping grooves A are arranged on the left, front and rear inner side walls of the EVC cage body, a pair of limiting blocks A are connected to the left, front and rear cross beams of the feed trough, the limiting blocks A are matched with the limiting block clamping grooves A, a sealing strip groove is arranged on the bottom surface of the EVC cage body, and a sealing strip is connected to the upper surface of the bedding trough and matched with the sealing strip groove.

[0012] Preferably, the main body partition plate comprises an "L"-shaped partition plate and an outer panel, the "L"-shaped partition plate and the outer panel are of an integrated structure, opposite clamping plate grooves are arranged on the right end surface of the "L"-shaped partition plate and the left end surface of the outer panel, a partition plate insertion slot and a pair of "T"-shaped sliding grooves are arranged on the left side wall of the EVC cage body, a partition plate supporting plate is fixed to the bottom of the EVC cage body, a partition plate clamping groove is arranged on the partition plate supporting plate, the "L"-shaped partition plate penetrates through the partition plate insertion slot and the bottom of the "L"-shaped partition plate is clamped in the partition plate clamping groove, two "T"-shaped sliding blocks are connected to the inner end surface of the partition plate clamping plate, spring columns A are connected to the "T"-shaped sliding blocks, the "T"-shaped sliding blocks are embedded in the "T"-shaped sliding grooves, the other end surface of the spring columns A is fixed in the "T"-shaped sliding grooves, and the partition plate clamping plate penetrates through the clamping plate grooves.

[0013] Preferably, the water bottle placing groove comprises a downwardly inclined water bottle groove bottom plate and a vertically structured water bottle groove side wall, a downwardly inclined water bottle communication pipe is connected to the inner end surface of the water bottle groove side wall, the water bottle is placed on the water bottle groove bottom plate and communicates with the water bottle communication pipe, a downwardly inclined water flow channel I and a horizontal water flow channel II are arranged in the water bottle groove side wall, the bottom of the water flow channel I communicates with the water flow channel II, the water outlets at both ends of the water flow channel II are arranged on the outer end surface of the water bottle groove side wall, the water dispenser I and the water dispenser II respectively communicate with the water outlets at both ends of the water flow channel II, a channel plug recess is arranged on the water flow channel II leading to one side of the water dispenser II, a threaded groove is arranged on the water bottle groove side wall, the channel plug recess and the threaded groove are in communication, and the valve of the water dispenser II comprises a "T"-shaped threaded pipe and a rubber plug, the rubber plug is bolted to the bottom of the "T"-shaped threaded pipe, the "T"-shaped threaded pipe is spirally sleeved in the threaded groove, and the rubber plug is embedded in the water flow channel II.

[0014] Preferably, the water bottle communication pipe is connected with an extrusion column in the pipe by a welding rod, the water bottle is connected with a water outlet pipe, the water outlet pipe is fixed with a sealing plug ring inside, the water outlet pipe is elastically connected with a sealing plug inside, the sealing plug side wall is connected with opposite connecting rods, the water outlet pipe inner wall is provided with opposite connecting rod sliding grooves, the connecting rod sliding grooves are fixed with spring columns B inside, the connecting rod is embedded in the connecting rod sliding grooves and connected with the spring columns B, the water outlet pipe is matched with the water bottle communication pipe, the extrusion column in the water bottle communication pipe is opposite to the sealing plug, and the diameter of the extrusion column is smaller than the inner diameter of the sealing plug ring.

[0015] Preferably, the water dispenser II is connected with a water dispenser II adjusting pipe at the outlet end of the water flow channel II, one end of the water dispenser II adjusting pipe is fixed on the outer end face of the water bottle groove side wall, the other end is connected with the water dispenser II, the water dispenser II and the water dispenser II adjusting pipe are connected with two opposite connecting plates, one end of the connecting plate is fixed on the water dispenser II, the other end is rotatably connected on the water dispenser II adjusting pipe, the water dispenser II adjusting pipe side wall is provided with two opposite pin sliding grooves, the connecting plate is elastically connected with a limiting pin, the limiting pin inner end face is embedded in the pin sliding groove, the limiting pin includes a "T" type inner pin and a pin outer tube, the pin outer tube is fixed on the connecting plate inner end face, the "T" type inner pin penetrates the connecting plate and is embedded in the pin outer tube, the "T" type inner pin and the connecting plate outer end face are connected with a spring column C, the "T" type inner pin bottom is connected with two pairs of "L" type pressing plates, the "L" type pressing plate bottom is arc-shaped structure, the pin outer tube is connected with a gasket, the pin outer tube is provided with a clamping groove ring, two pairs of pressing plate sliding grooves and two pairs of clamping slot, the clamping groove ring, two pairs of pressing plate sliding grooves and two pairs of clamping slot are sequentially arranged from top to bottom, the "L" type pressing plate penetrates the pressing plate sliding groove, and the inner end face of the vertical section of the "L" type pressing plate abuts against the pin outer tube outer wall, the pin outer tube is elastically connected with two pairs of arc-shaped fixed plates, the arc-shaped fixed plate outer end face is connected with a pair of spring columns D and an arc-shaped clamping piece, the pair of spring columns D are respectively fixed on the left and right sides of the arc-shaped clamping piece, the arc-shaped fixed plate covers the clamping slot, the pin sliding groove inner bottom surface and upper surface are provided with opposite clamping grooves, and the arc-shaped clamping piece penetrates the clamping slot and is embedded in the clamping groove.

[0016] Preferably, the water dispenser II is provided with a sealing ring groove on the end face of the water outlet of the adjusting pipe, a sealing ring is connected to the end face of the water inlet of the water dispenser II, the sealing ring is matched with the sealing ring groove, a pipe plug chain is connected between the adjusting pipe of the water dispenser II and the water dispenser II, the pipe plug chain comprises two sealing ball plugs, a plug rod is connected to each of the two sealing ball plugs, a chain is connected between the two plug rods, plug chain fixing rings I and II are fixed in the adjusting pipe of the water dispenser II and the water dispenser II respectively, a plurality of water outlet holes are arranged on the plug chain fixing ring II, and the sealing ball plugs are located between the plug chain fixing ring I and the plug chain fixing ring II.

[0017] Preferably, the pad slot is provided with a pad slot opening on the front and rear side walls, the pad slot side wall baffle is embedded on the pad slot opening, two baffle clamping blocks are elastically connected to the right side wall of the pad slot, the pad slot side wall baffle has an "L" type structure, a clamping block groove A is arranged on the right end face of the pad slot side wall baffle, the baffle clamping block comprises an arc-shaped panel and a limiting tube, the limiting tube is fixed at the bottom of the arc-shaped panel, a spring column E is fixed in the limiting tube, two limiting tube grooves are arranged on the right side wall of the pad slot, the limiting tube is embedded in the limiting tube groove, and the spring column E is bolted to the bottom surface of the limiting tube groove.

[0018] Preferably, a pair of limiting blocks B are connected to the outer wall of the limiting tube, a pair of limiting block clamping grooves B and a circular sliding groove are arranged on the inner wall of the limiting tube groove, the upper end of the limiting block clamping groove B is communicated with the circular sliding groove, and the limiting block B is matched with the limiting block clamping groove B.

[0019] Preferably, a welding block is fixed to the inner bottom surface of the pad slot, a rotating shaft is connected to the two ends of the welding block, two rotating shaft sleeves are connected to the bottom of the pad slot partition plate, the rotating shaft is sleeved in the rotating shaft sleeve, two partition plate clamping blocks are elastically connected to the left and right side walls of the pad slot partition plate, a "T"-shaped clamping block adjusting rod is connected to the two opposite side walls of each partition plate clamping block, clamping block grooves B are arranged on the left and right side walls of the pad slot partition plate, spring columns F are fixed in the clamping block grooves B, adjusting rod sliding grooves are arranged on the front and rear end faces of the pad slot partition plate, the partition plate clamping blocks are embedded in the clamping block grooves B and connected with the spring columns F, the "T"-shaped clamping block adjusting rods penetrate through the adjusting rod sliding grooves, and opposite clamping block limiting grooves are arranged on the left and right inner side walls of the pad slot, and the partition plate clamping blocks are matched with the clamping block limiting grooves.

[0020] The SPF level mouse closed colony animal model establishment special EVC cage has the following advantages:

[0021] 1. The EVC cage body disclosed in this invention has a main body partition plate inserted into it, and a partition plate retainer is elastically connected to the outer wall of the EVC cage body. The partition plate retainer holds the main body partition plate onto the EVC cage body. When there is no need to divide the cage, the main body partition plate is in an unused state. When it is necessary to divide the EVC cage body, the main body partition plate is inserted into the EVC cage body and fixed by the partition plate retainer. The main body partition plate divides the EVC cage body, which can minimize the impact of cage division on pregnant female mice, thereby reducing the possibility of pregnant female mice being frightened and increasing the likelihood of them eating their offspring after giving birth.

[0022] 2. The EVC cage body disclosed in this invention is connected to a bedding trough. Bedding trough sidewall baffles are embedded on the front and rear side walls of the bedding trough. A flip-up bedding trough partition is connected inside the bedding trough. When the bedding needs to be changed, the bedding trough sidewall baffles on the front and rear side walls of the bedding trough are removed, and the bedding in the bedding trough is changed from the side. This can minimize the impact of changing the bedding on pregnant female mice, thereby reducing the possibility of pregnant female mice being frightened and increasing the possibility of eating their offspring after giving birth. The bedding trough partition can separate bedding that is contaminated with the scent of different female mice, preparing for the feeding of pups with milk.

[0023] 3. The water bottle placement slot inside the EVC cage disclosed in this invention is equipped with a water drinker I and a water drinker II that can be flipped up and down. The water bottle placement slot is equipped with a valve for water drinker II. When there is no need to separate the cages, the valve of water drinker II is closed, water drinker II is in a non-use state, and water drinker I is in a use state. At the same time, water drinker II is flipped down, which can save space inside the EVC cage and prevent mice from touching water drinker II during their activities, causing water drinker II to leak, wet the bedding and cause bacterial growth. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0025] Figure 2 This is a cross-sectional schematic diagram of the connection structure between the main partition plate and the main body of the EVC cage of the present invention.

[0026] Figure 3 This is a schematic diagram of the connection structure between the water bottle and the water bottle placement slot of the present invention.

[0027] Figure 4 For the present invention Figure 3 The diagram shows the enlarged structure of section A, which is the water outlet pipe.

[0028] Figure 5 This is a schematic diagram of the cross-sectional structure of the side wall of the water bottle tank of the present invention.

[0029] Figure 6 This is a schematic diagram of the connection structure between the inside of the water bottle slot sidewall and the valve of the water dispenser II according to the present invention.

[0030] Figure 7 Figure 2 is a schematic diagram of the connection structure of the adjusting pipe and the water dispenser II.

[0031] Figure 8 Figure 3 is a schematic diagram of the pipeline plug chain structure.

[0032] Figure 9 Figure 4 is a schematic diagram of the adjusting pipe structure of the water dispenser II.

[0033] Figure 10 Figure 5 is a schematic diagram of the internal connection structure of the limiting pin and the connecting plate.

[0034] Figure 11 Figure 6 is a schematic diagram of the connection structure of the cushion groove and the cushion groove side wall baffle.

[0035] Figure 12 Figure 7 is a schematic diagram of the connection structure of the baffle clamping block and the cushion groove.

[0036] Figure 13 Figure 8 is a schematic diagram of the connection structure of the cushion groove partition plate and the cushion groove.

[0037] In the figure: 1, EVC cage main body, 2, cage cover, 3, water bottle placement groove, 3-1, water bottle groove bottom plate, 3-2, water bottle groove side wall, 4, feed trough, 5, water bottle, 6, limit block clamping groove A, 7, limit block A, 8, bedding trough, 9, main body partition plate, 9-1, "L" type partition plate, 9-2, outer panel, 10, bedding trough partition plate, 11, bedding trough side wall baffle, 12, baffle clamping block, 12-1, arc panel, 12-2, limit tube, 13, sealing strip, 14, sealing strip groove, 15, clamping plate groove, 16, partition plate insertion slot, 17, partition plate clamping plate, 18, "T" type sliding groove, 19, "T" type sliding block, 20, spring column A, 21, water dispenser I, 22, water dispenser II adjusting tube, 23, water dispenser II, 24, water bottle communication pipe, 25, extrusion column, 26, water outlet pipe, 27, sealing plug clamping ring, 28, sealing plug, 29, connecting rod sliding groove, 30, connecting rod, 31, spring column B, 32, water flow channel I, 33, water flow channel II, 34, channel plug groove, 35, threaded groove, 37, water dispenser II valve, 37-1, "T" type threaded tube, 37-2, rubber plug, 38, sealing ring groove, 39, sealing ring, 40, connecting plate, 41, limit pin, 41-1, "T" type inner pin, 41-2, pin outer tube, 42, pin sliding groove, 43, pipe plug chain, 43-1, sealing ball plug, 43-2, plug rod, 43-3, chain, 44, plug chain fixing ring I, 45, plug chain fixing ring II, 46, water outlet hole, 47, clasp groove, 48, spring column C, 49, "L" type pressing plate, 50, gasket, 51, clamping groove ring, 52, pressing plate sliding groove, 53, clasp through groove, 54, arc fixing plate, 55, spring column D, 56, arc clasp, 57, bedding trough opening, 58, clamping block groove A, 59, spring column E, 60, limit tube groove, 61, limit block B, 62, limit block clamping groove B, 63, circular sliding groove, 64, welding block, 65, rotating shaft, 66, clamping block groove B, 67, partition plate clamping block, 68, spring column F, 69, "T" type clamping block adjusting rod, 70, adjusting rod sliding groove, 71, rotating shaft sleeve, 72, clamping block limit slot, 73, horizontal column, 74, partition plate support plate, 75, partition plate clamping groove. DETAILED DESCRIPTION

[0038] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0039] In the description of the present application, it should be noted that the terms "upper", "lower", "inner" and "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0040] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting" should be broadly understood, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0041] The present application provides an EVC cage which can isolate pregnant mice in a quiet state and obtain a lactating mouse odor pad without affecting the lactating mouse, specifically as follows:

[0042] As shown in Figure 1 and Figure 2 , a special EVC cage for establishing an SPF level mouse closed colony animal model comprises an EVC cage body 1 and a cage cover 2, a water bottle placing groove 3 is arranged on the right side of the inside of the EVC cage body 1, a feed trough 4 is arranged on the left side of the inside of the EVC cage body 1, a water bottle 5 is placed on the water bottle placing groove 3 to provide drinking water for mice, feed is added on the feed trough 4 for mice to freely eat, a main body partition plate 9 is inserted on the EVC cage body 1, and a partition plate clamping plate 17 is elastically connected on the outer wall of the EVC cage body 1, the partition plate clamping plate 17 clamps the main body partition plate 9 on the EVC cage body 1, the main body partition plate 9 is in a non-use state without the need for partitioning, and when the EVC cage body 1 needs to be partitioned, the main body partition plate 9 is inserted on the EVC cage body 1 and fixed through the partition plate clamping plate 17.

[0043] As shown in Figure 1 and Figure 3As shown, the water bottle placing groove 3 is provided with a drinking device I 21 and a drinking device II 23 which can be turned up and down, the water bottle 5 is communicated with the drinking device I 21 and the drinking device II 23 respectively, the water bottle placing groove 3 is provided with a drinking device II valve 37, without separating the cage, the drinking device II valve 37 is closed, the drinking device II 23 is in a non-use state, the drinking device I 21 is in a use state, and the drinking device II 23 is turned down, which can save the space in the EVC cage body 1, and can avoid the mouse touching the drinking device II 23 in the activity process to cause the drinking device II 23 to leak water and cause the bacteria to breed.

[0044] As shown in Figure 1 and Figure 2 , the EVC cage body 1 is of an open bottom structure, and a plurality of horizontal bars 73 are installed at the bottom of the EVC cage body 1, a bedding trough 8 is connected to the bottom of the EVC cage body 1, bedding trough side wall baffles 11 are embedded on the front and rear side walls of the bedding trough 8, and a bedding trough partition plate 10 which can be turned over is connected in the bedding trough 8.

[0045] The parent mice are put into the EVC cage body 1 for breeding, and the mouse breeding production is generally mated at 2:1, that is, one male and two females are caged together, the bedding trough 8 is laid with bedding, and the horizontal bars 73 can prevent the parent mice from falling into the bedding trough 8, when the bedding needs to be replaced, the bedding trough side wall baffles 11 on the front and rear side walls of the bedding trough 8 are removed, and the bedding in the bedding trough 8 is replaced from the side; the bedding trough partition plate 10 can separate the bedding with different mother mouse odors to prepare for the baby mouse lactation feeding.

[0046] As shown in Figure 1 , a pair of limiting block clamping grooves A6 are arranged on the left, front and rear inner side walls of the EVC cage body 1, a pair of limiting blocks A7 are connected to the left, front and rear cross beams of the feed trough 4, and the limiting blocks A7 are embedded in the matching limiting block clamping grooves A6, so that the feed trough 4 is placed in the EVC cage body 1, and the limiting blocks A7 are embedded in the limiting block clamping grooves A6.

[0047] As shown in Figure 1 and Figure 2 , a sealing strip groove 14 is arranged on the bottom surface of the EVC cage body 1, and a sealing strip 13 is connected to the upper surface of the bedding trough 8, so that the bedding trough 8 is clamped on the EVC cage body 1, and the sealing strip 13 is embedded in the sealing strip groove 14.

[0048] As shown in Figure 1 and Figure 2As shown, the main body partition plate 9 includes an "L" type partition plate 9-1 and an outer panel 9-2, which are of an integral structure, and opposite clamping plate grooves 15 are arranged on the right end surface of the "L" type partition plate 9-1 and the left end surface of the outer panel 9-2. A partition plate insertion slot 16 and a pair of "T" type sliding grooves 18 are arranged on the left side wall of the EVC cage main body 1, and a partition plate supporting plate 74 is fixed at the bottom of the EVC cage main body 1, and a partition plate clamping groove 75 is arranged on the partition plate supporting plate 74. The "L" type partition plate 9-1 penetrates the partition plate insertion slot 16 and is clamped in the partition plate clamping groove 75 at the bottom of the "L" type partition plate 9-1. Two "T" type sliding blocks 19 are connected to the inner end surface of the partition plate clamping plate 17, and a spring column A 20 is connected to the "T" type sliding block 19. The "T" type sliding block 19 is embedded in the "T" type sliding groove 18, and the other end surface of the spring column A 20 is fixed in the "T" type sliding groove 18. The partition plate clamping plate 17 penetrates the clamping plate grooves 15.

[0049] After observing that the female mice are obviously bloated and determining that they are pregnant, the male mice are taken out of the EVC cage main body 1, and the EVC cage main body 1 needs to be separated into two cages for feeding two pregnant mice separately, in preparation for the next birth and lactation. The specific method is as follows:

[0050] When observing that the two pregnant mice are on the two sides of the EVC cage main body 1, the partition plate clamping plate 17 is pushed outwards to expose the partition plate insertion slot 16, at this time the spring column A 20 is in a compressed state, and the "L" type partition plate 9-1 is inserted into the EVC cage main body 1 through the partition plate insertion slot 16. The bottom of the "L" type partition plate 9-1 is clamped in the partition plate clamping groove 75. After the "L" type partition plate 9-1 is completely inserted, the outer panel 9-2 abuts against the side wall of the EVC cage main body 1, and then the partition plate clamping plate 17 is loosened. The partition plate clamping plate 17 is restored to its original position under the elastic force of the spring column A 20, and the partition plate clamping plate 17 penetrates the clamping plate grooves 15 on the outer panel 9-2. The main body partition plate 9 is fixed in the EVC cage main body 1, and the two pregnant mice are fed separately by the main body partition plate 9.

[0051] As shown in FIG. 8, the EVC cage main body 1 is provided with a main body partition plate 9, and the main body partition plate 9 is provided with a partition plate clamping plate 17. Figures 1-3 , Figure 5 and Figure 6As shown in the drawings, the water bottle placing groove 3 comprises a downwardly inclined water bottle groove bottom plate 3-1 and a vertically structured water bottle groove side wall 3-2, a downwardly inclined water bottle communication pipe 24 is connected to the inner end face of the water bottle groove side wall 3-2, the inclined angle of the water bottle communication pipe 24 is the same as the inclined angle of the water bottle groove bottom plate 3-1, the water bottle 5 is placed on the water bottle groove bottom plate 3-1 and communicates with the water bottle communication pipe 24, a downwardly inclined water flow passage I 32 and a transversal water flow passage II 33 are arranged in the water bottle groove side wall 3-2, the bottom of the water flow passage I 32 communicates with the water flow passage II 33, the water outlets of the two ends of the water flow passage II 33 are arranged on the outer end face of the water bottle groove side wall 3-2, the water dispenser I 21 and the water dispenser II 23 respectively communicate with the water outlets of the two ends of the water flow passage II 33, a passage plug recess 34 is arranged on the water flow passage II 33 leading to the side of the water dispenser II 23, a threaded groove 35 is arranged on the water bottle groove side wall 3-2, the passage plug recess 34 and the threaded groove 35 communicate with each other, the water dispenser II valve 37 comprises a "T" type threaded pipe 37-1 and a rubber plug 37-2, the rubber plug 37-2 is bolted to the bottom of the "T" type threaded pipe 37-1, the "T" type threaded pipe 37-1 is spirally sleeved in the threaded groove 35, and the rubber plug 37-2 is embedded in the water flow passage II 33.

[0052] During the mixed feeding process, the water dispenser II valve 37 is in a closed state, that is, the "T" type threaded pipe 37-1 is turned downwardly to the rubber plug 37-2 to plug the water flow passage II 33 leading to the side of the water dispenser II 23, and the water dispenser II 23 is in a non-use state; during the isolated feeding process of the two pregnant mice, the water dispenser II valve 37 is in an open state, that is, the "T" type threaded pipe 37-1 is turned upwardly to the rubber plug 37-2 to move into the passage plug recess 34, the water flow passage II 33 leading to the side of the water dispenser II 23 is opened, and the water dispenser II 23 is in a useable state.

[0053] As shown in the drawings, Figure 3 and Figure 4 As shown in the drawings, the water bottle communication pipe 24 is connected with an extrusion column 25 through a welding rod, the water bottle 5 is connected with a water outlet pipe 26, the water outlet pipe 26 is fixed with a sealing plug ring 27, the water outlet pipe 26 is elastically connected with a sealing plug 28, the side wall of the sealing plug 28 is connected with opposite connecting rods 30, the inner wall of the water outlet pipe 26 is provided with opposite connecting rod sliding grooves 29, the connecting rod sliding grooves 29 are fixed with spring columns B 31, the connecting rods 30 are embedded in the connecting rod sliding grooves 29 and connected with the spring columns B 31, the water outlet pipe 26 matches with the water bottle communication pipe 24, the extrusion column 25 in the water bottle communication pipe 24 is opposite to the sealing plug 28, and the diameter of the extrusion column 25 is smaller than the inner diameter of the sealing plug ring 27.

[0054] In normal state, the sealing plug 28 in the water outlet pipe 26 of the water bottle 5 is pushed into the inner ring of the sealing plug ring 27 by the spring column B31, and the water outlet pipe 26 is in a sealed state; the water outlet pipe 26 of the water bottle 5 is embedded in the water bottle connecting pipe 24, the extrusion column 25 in the water bottle connecting pipe 24 extrudes the sealing plug 28 inward, the sealing plug 28 is out of the sealing plug ring 27, the water outlet pipe 26 is opened, and the water in the water bottle 5 flows into the water bottle connecting pipe 24 through the water outlet pipe 26.

[0055] As shown in Figure 3 , Figure 7 , Figure 9 and Figure 10 , the water dispenser II 23 and the water flow channel II 33 outlet end are connected with the water dispenser II adjusting pipe 22, one end of the water dispenser II adjusting pipe 22 is fixed on the outer end surface of the water bottle groove side wall 3-2, the other end is connected with the water dispenser II 23, two opposite connecting plates 40 are connected between the water dispenser II 23 and the water dispenser II adjusting pipe 22, one end of the connecting plate 40 is fixed on the water dispenser II 23, the other end is rotatably connected on the water dispenser II adjusting pipe 22, two opposite pin sliding grooves 42 are arranged on the side wall of the water dispenser II adjusting pipe 22, a limiting pin 41 is elastically connected on the connecting plate 40, the inner end surface of the limiting pin 41 is embedded in the pin sliding groove 42, the limiting pin 41 includes a "T" type inner pin 41-1 and a pin outer tube 41-2, the pin outer tube 41-2 is fixed on the inner end surface of the connecting plate 40, the "T" type inner pin 41-1 penetrates through the connecting plate 40 and is embedded in the pin outer tube 41-2, a spring column C 48 is connected between the "T" type inner pin 41-1 and the outer end surface of the connecting plate 40, two pairs of "L" type pressing plates 49 are connected at the bottom of the "T" type inner pin 41-1, the bottom of the "L" type pressing plate 49 is arc-shaped structure, a gasket 50 is connected on the pin outer tube 41-2, a clamping groove ring 51, two pairs of pressing plate sliding grooves 52 and two pairs of clamping pin through grooves 53 are arranged on the pin outer tube 41-2, the clamping groove ring 51, two pairs of pressing plate sliding grooves 52 and two pairs of clamping pin through grooves 53 are arranged from top to bottom in sequence, the pin outer tube 41-2 is embedded in the pin sliding groove 42, and the outer wall of the pin sliding groove 42 is clamped in the clamping groove ring 51, the "L" type pressing plate 49 penetrates through the pressing plate sliding groove 52, and the inner end surface of the vertical section of the "L" type pressing plate 49 abuts against the outer wall of the pin outer tube 41-2, two pairs of arc-shaped fixing plates 54 are elastically connected in the pin outer tube 41-2, a pair of spring columns D 55 and an arc-shaped clamping pin 56 are connected on the outer end surface of the arc-shaped fixing plate 54, the pair of spring columns D 55 are respectively fixed on the left and right sides of the arc-shaped clamping pin 56, the arc-shaped fixing plate 54 covers the clamping pin through groove 53, the inner bottom surface and the upper surface of the pin sliding groove 42 are provided with opposite clamping pin grooves 47, the arc-shaped clamping pin 56 penetrates through the clamping pin through groove 53 and is embedded in the clamping pin groove 47.

[0056] In the non-use state of the water dispenser II 23, in order to save the space in the EVC cage body 1, and to avoid the mouse from touching the water dispenser II 23 during the activity, causing the water dispenser II 23 to leak water, wet the bedding and cause bacterial growth, the water dispenser II 23 can be turned down 90° relative to the water dispenser II adjusting pipe 22, the specific operation is as follows:

[0057] Press the "T" type inner pin 41-1 inward, at this time the spring column C 48 is in a compressed state, the "L" type pressing plate 49 on the "T" type inner pin 41-1 moves inward along the pressing plate sliding groove 52, and the arc-shaped clamp 56 is extruded inward during the movement of the "L" type pressing plate 49, and the arc-shaped clamp 56 is extruded out of the clamp groove 47, at this time the spring column D 55 is in a stretched state, and the limiting pin 41 is in a state of being movable forward and backward along the pin sliding groove 42, the water dispenser II 23 is pushed forward to the rightmost end of the pin sliding groove 42, at this time the water dispenser II 23 is separated from the water dispenser II adjusting pipe 22, and the water dispenser II 23 is turned down 90° relative to the water dispenser II adjusting pipe 22, at this time the connecting plate 40 is also turned down 90° relative to the water dispenser II adjusting pipe 22, and then the water dispenser II 23 is pushed backward to the leftmost end of the pin sliding groove 42, the "T" type inner pin 41-1 is released, and the "T" type inner pin 41-1 is restored to the original position under the action of the spring column C 48, the "L" type pressing plate 49 moves outward along the pressing plate sliding groove 52, the pressure acting on the arc-shaped clamp 56 disappears, the arc-shaped clamp 56 is popped out under the action of the restoring force of the spring column D 55, and the front end of the arc-shaped clamp 56 is re-clamped in the clamp groove 47, and the limiting pin 41 is re-fixed on the water dispenser II adjusting pipe 22.

[0058] After the water dispenser II 23 is turned down 90° relative to the water dispenser II adjusting pipe 22, the water inlet end of the water dispenser II 23 and the water outlet end of the water dispenser II adjusting pipe 22 are both in an open structure, in order to ensure the cleanliness of the pipeline of the water dispenser II 23 and the water dispenser II adjusting pipe 22, the water dispenser II 23 and the water dispenser II adjusting pipe 22 after being turned down 90° need to be sealed, the specific improvement is as follows:

[0059] As Figures 7-9As shown, the water dispenser II adjustment pipe 22 outlet end face is provided with a sealing ring groove 38, the water dispenser II 23 inlet end face is connected with a sealing ring 39, the sealing ring 39 is embedded in the sealing ring groove 38, the water dispenser II 23 is fixed on the water dispenser II adjustment pipe 22, the water dispenser II adjustment pipe 22 and the water dispenser II 23 are connected with a pipe plug chain 43, the pipe plug chain 43 includes two sealing ball plugs 43-1, the two sealing ball plugs 43-1 are connected with plug rods 43-2, the two plug rods 43-2 are connected with a chain 43-3, the water dispenser II adjustment pipe 22 and the water dispenser II 23 are relatively fixed with plug chain fixing ring I 44 and plug chain fixing ring II 45, the plug chain fixing ring II 45 is provided with a plurality of water outlets 46, and the sealing ball plug 43-1 is located between the plug chain fixing ring I 44 and the plug chain fixing ring II 45.

[0060] When the water dispenser II 23 is overturned by 90° relative to the water dispenser II adjustment pipe 22, the sealing ball plug 43-1 located in the water dispenser II 23 and the water dispenser II adjustment pipe 22 is stretched outward to be clamped in the plug chain fixing ring I 44, at this time, the water dispenser II 23 and the water dispenser II adjustment pipe 22 are in a sealed state; when it is needed to open the pipe of the water dispenser II 23 and the water dispenser II adjustment pipe 22, the sealing ball plug 43-1 is pushed inward to be clamped on the plug chain fixing ring II 45, and water flows out through the water outlets 46 on the plug chain fixing ring II 45.

[0061] As shown in Figure 1 , Figure 11 and Figure 12 , the cushion groove 8 front and rear side walls are provided with cushion groove openings 57, the cushion groove side wall baffle 11 is embedded on the cushion groove opening 57, the right side wall of the cushion groove 8 is elastically connected with two baffle clamping blocks 12, the cushion groove side wall baffle 11 is of "L" type structure, the right end face of the cushion groove side wall baffle 11 is provided with a clamping block groove A 58, the baffle clamping block 12 includes an arc-shaped panel 12-1 and a limiting tube 12-2, the limiting tube 12-2 is fixed at the bottom of the arc-shaped panel 12-1, a spring column E 59 is fixed in the limiting tube 12-2, the right side wall of the cushion groove 8 is provided with two limiting tube grooves 60, the limiting tube 12-2 is embedded in the limiting tube groove 60, and the bottom of the spring column E 59 is bolted to the bottom surface of the limiting tube groove 60.

[0062] When the cushion needs to be replaced, the baffle clamping block 12 is pulled out outward and rotated by 180°, the arc-shaped panel 12-1 is out of the clamping block groove A 58 on the cushion groove side wall baffle 11, at this time, the cushion groove side wall baffle 11 can be taken off from the cushion groove 8, the cushion groove opening 57 is opened, and the cushion in the cushion groove 8 can be replaced.

[0063] In the process of pulling out the baffle block 12, in order to prevent the limiting tube 12-2 from being pulled out of the limiting tube groove 60, the application makes the following improvements:

[0064] As shown in Figure 12 , a pair of limiting blocks B61 are connected to the outer wall of the limiting tube 12-2, a pair of limiting block clamping grooves B62 and a circular sliding groove 63 are arranged on the inner wall of the limiting tube groove 60, the upper end of the limiting block clamping groove B62 is connected with the circular sliding groove 63, and the limiting block B61 matches with the limiting block clamping groove B62.

[0065] When the baffle block 12 is pulled out, the limiting block B61 on the limiting tube 12-2 moves outward along the limiting block clamping groove B62 and is clamped into the circular sliding groove 63, and in the process of rotating the baffle block 12 by 180°, the limiting block B61 rotates along the circular sliding groove 63.

[0066] The case of eating babies by female mice usually occurs in female mice that have given birth for the first time, so in the breeding process, one of the two female mice in the same cage is a female mouse that has given birth for the first time, and the other can be a female mouse that has given birth multiple times. Once it is found that the female mouse that has given birth for the first time eats babies, the baby of the female mouse that has given birth for the first time can be fed by another female mouse in the same cage. The specific method is as follows:

[0067] As shown in Figure 1 and Figure 13 , a welding block 64 is fixed on the inner bottom surface of the bedding trough 8, a rotating shaft 65 is connected to both ends of the welding block 64, two rotating shaft sleeves 71 are connected to the bottom of the bedding trough partition plate 10, the rotating shaft 65 is sleeved in the rotating shaft sleeve 71, two bedding trough partition plate clamping blocks 67 are elastically connected to the left and right side walls of the bedding trough partition plate 10, a "T"-shaped clamping block adjusting rod 69 is connected to the two opposite side walls of each bedding trough partition plate clamping block 67, a clamping block groove B66 is arranged on the left and right side walls of the bedding trough partition plate 10, a spring column F68 is fixed in the clamping block groove B66, two adjusting rod sliding grooves 70 are arranged on the front and rear end faces of the bedding trough partition plate 10, the bedding trough partition plate clamping block 67 is embedded in the clamping block groove B66 and connected with the spring column F68, the "T"-shaped clamping block adjusting rod 69 penetrates through the adjusting rod sliding groove 70, and a clamping block limiting groove 72 is arranged on the left and right inner side walls of the bedding trough 8, and the bedding trough partition plate clamping block 67 matches with the clamping block limiting groove 72.

[0068] The mother mouse that eats the mouse in the same cage is taken out, at the same time, the side wall baffle 11 of the bedding trough on the side of the mother mouse is taken off, all the bedding in the bedding trough 8 on the side of the mother mouse is taken out, and the "T" type clamping block adjusting rod 69 on the bedding trough partition 10 is pressed to the middle. At this time, the spring column F68 is in a compressed state, the partition clamping block 67 is pressed into the clamping block groove B66 and is out of the clamping block limiting groove 72, at this time, the bedding trough partition 10 is in a reversible state, the bedding trough partition 10 is turned to the side of the empty bedding trough 8 by 45°-60°, the upper layer of bedding in the other side of the bedding trough 8 is pushed into the empty side of the bedding trough 8. Since the smell of the mother mouse attached to the upper layer of bedding is more intense, the upper layer of bedding is selected during this process, and then the bedding trough partition 10 is turned to the original position again, the "T" type clamping block adjusting rod 69 is loosened, the partition clamping block 67 is popped out of the clamping block groove B66 and embedded in the clamping block limiting groove 72 under the elastic force of the spring column F68, and the bedding trough partition 10 is fixed in the bedding trough 8 again. Then the bedding trough side wall baffle 11 is reinstalled on the bedding trough 8, and the smell of the lactating mother mouse is attached to the young mouse that needs to be fed with milk replacer. Then the main body partition 9 is taken out, the young mouse that needs to be fed with milk replacer is in contact with the lactating mother mouse, and the young mouse replacement feeding begins.

[0069] Example 1: Pregnant mice are individually fed in the same cage

[0070] The parent mice are put into the EVC cage main body 1 for breeding, and the mouse breeding production is generally 2:1 mating, that is, one male and two females are put into the same cage, and the two females are first-time production and multiple production females. After observing that the abdomen of the female mouse is obviously swollen to determine that it is pregnant, the male mouse is taken out of the EVC cage main body 1, and the EVC cage main body 1 needs to be divided into cages at the same time. Two pregnant mice in the EVC cage main body 1 are separated and fed, and preparations are made for the following birth and lactation. The specific method is as follows:

[0071] When it is observed that the two pregnant mice are respectively on the two sides of the EVC cage main body 1, the partition clamping plate 17 is pushed outwards to expose the partition slot 16, at this time the spring column A20 is in a compressed state, at the same time the "L" type partition 9-1 is inserted into the EVC cage main body 1 through the partition slot 16, the bottom of the "L" type partition 9-1 is clamped in the partition clamping groove 75, and after the "L" type partition 9-1 is completely inserted, the outer panel 9-2 abuts against the side wall of the EVC cage main body 1, and then the partition clamping plate 17 is loosened. The partition clamping plate 17 returns to the original position under the elastic force of the spring column A20, and the partition clamping plate 17 penetrates the clamping plate groove 15 on the outer panel 9-2, the main body partition 9 is fixed in the EVC cage main body 1, and the two pregnant mice are separated and fed by the main body partition 9.

[0072] At this time, the water dispenser II 23 needs to be opened, and the specific operation is as follows:

[0073] Push the sealing ball plug 43-1 inward to make it stuck on the plug chain fixing ring II 45, the water flows out through the water outlet hole 46 on the plug chain fixing ring II 45, and the water dispenser II 23 and the water dispenser II adjusting pipe 22 are opened;

[0074] Push the "T" type inner pin 41-1 inward, at this time the spring column C 48 is in a compressed state, the "L" type pressing plate 49 on the "T" type inner pin 41-1 moves inward along the pressing plate sliding groove 52, and the arc-shaped clamp 56 is extruded inward during the movement of the "L" type pressing plate 49, so that the arc-shaped clamp 56 is extruded to be out of the clamp groove 47, at this time the spring column D 55 is in a stretched state, and the limiting pin 41 is in a state of being movable forward and backward along the pin sliding groove 42. Push the water dispenser II 23 forward to the right end of the pin sliding groove 42, and at the same time, turn the water dispenser II 23 upward by 90°, then push the water dispenser II 23 backward to the left end of the pin sliding groove 42, and the sealing ring 39 is embedded in the sealing ring groove 38. Loosen the "T" type inner pin 41-1, and the "T" type inner pin 41-1 returns to the original position under the elastic force of the spring column C 48. The "L" type pressing plate 49 moves outward along the pressing plate sliding groove 52, the pressure acting on the arc-shaped clamp 56 disappears, the arc-shaped clamp 56 is popped out under the restoring force of the spring column D 55, and the front end of the arc-shaped clamp 56 is re-stuck in the clamp groove 47. The limiting pin 41 is re-fixed on the water dispenser II adjusting pipe 22, at this time the water dispenser II 23 is in a usable state.

[0075] Example 2: Pad replacement

[0076] Pull out the baffle clamp block 12, the limiting block B 61 on the limiting pipe 12-2 moves outward along the limiting block clamping groove B 62 and is clamped into the circular sliding groove 63, and the baffle clamp block 12 is turned by 180°, and the arc-shaped panel 12-1 is out of the clamp block groove A 58 on the pad groove side wall baffle 11. At this time, the pad groove side wall baffle 11 can be removed from the pad groove 8, and the pad groove opening 57 is opened, so that the pad in the pad groove 8 can be replaced.

[0077] Example 3: Feeding of mouse milk replacer

[0078] The mother mouse which eats the baby mouse in the same cage is taken out, at the same time, the side wall baffle 11 of the litter trough on the side of the mother mouse is taken off, all the litter in the litter trough 8 on the side of the mother mouse is taken out, and the "T" type clamping block adjusting rod 69 on the litter trough partition 10 is pressed to the middle, at this time, the spring column F68 is in a compressed state, the partition clamping block 67 is pressed into the clamping block groove B66 and is taken out of the clamping block limiting groove 72, at this time, the litter trough partition 10 is in a reversible state, the litter trough partition 10 is turned to the side of the empty litter trough 8 by 45°-60°, the upper layer of litter in the other side of the litter trough 8 is pushed into the empty side of the litter trough 8, because the smell of the mother mouse attached to the upper layer of litter is more intense, so the upper layer of litter is selected in this process, and then the litter trough partition 10 is turned to the original position again, the "T" type clamping block adjusting rod 69 is loosened, the partition clamping block 67 is taken out of the clamping block groove B66 and is embedded in the clamping block limiting groove 72 under the elastic force of the spring column F68, the litter trough partition 10 is fixed in the litter trough 8 again, and then the litter trough side wall baffle 11 is reinstalled on the litter trough 8, after the smell of the lactating mother mouse is attached to the baby mouse which needs to be fed with milk replacer, the main body partition 9 is taken out, the baby mouse which needs to be fed with milk replacer contacts the lactating mother mouse, and the baby mouse replacement feeding is started.

[0079] It will be obvious to a person skilled in the art that, without departing from the spirit or essential characteristics of the application, the present application can be implemented in other specific forms. The present examples are therefore to be considered in all respects as illustrative and not restrictive, the scope of the application being indicated by the appended claims rather than by the description given above, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference signs in the claims should not be construed as limiting the scope of the claims.

[0080] In addition, it should be understood that, although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the description of the specification is only for the sake of clarity, and those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can be combined appropriately to form other embodiments which can be understood by those skilled in the art.

Claims

1. A special EVC cage for establishing an SPF level mouse closed colony animal model, comprising an EVC cage body (1) and a cage cover (2), a water bottle placing groove (3) is arranged on the right side of the inside of the EVC cage body (1), a feed trough (4) is arranged on the left side of the inside of the EVC cage body (1), and a water bottle (5) is placed on the water bottle placing groove (3), characterized in that: The EVC cage body (1) is inserted with a body partition plate (9), and the outer side wall of the EVC cage body (1) is elastically connected with a partition plate clamping plate (17), the body partition plate (9) is fixed on the EVC cage body (1) through the partition plate clamping plate (17), the water bottle placing groove (3) is installed with a water dispenser I (21) and a water dispenser II (23) which can be turned up and down, the water bottle (5) is connected with the water dispenser I (21) and the water dispenser II (23) respectively, the water bottle placing groove (3) is installed with a water dispenser II valve (37), the EVC cage body (1) is of an open bottom structure, and the EVC cage body (1) is installed with a plurality of horizontal columns (73) at the bottom, the EVC cage body (1) is connected with a bedding trough (8) at the bottom, the bedding trough (8) is embedded with a bedding trough side wall baffle (11) on the front and rear side walls, the bedding trough (8) is connected with a bedding trough partition plate (10) which can be turned over, ​ The body partition plate (9) comprises an "L" type partition plate (9-1) and an outer panel (9-2), the "L" type partition plate (9-1) and the outer panel (9-2) are of an integral structure, the right end surface of the "L" type partition plate (9-1) and the left end surface of the outer panel (9-2) are provided with opposite clamping plate grooves (15), the left side wall of the EVC cage body (1) is provided with a partition plate insertion slot (16) and a pair of "T" type sliding grooves (18), the bottom of the EVC cage body (1) is fixed with a partition plate supporting plate (74), the partition plate supporting plate (74) is provided with a partition plate clamping groove (75), the "L" type partition plate (9-1) penetrates through the partition plate insertion slot (16) and the bottom of the "L" type partition plate (9-1) is clamped in the partition plate clamping groove (75), the inner end surface of the partition plate clamping plate (17) is connected with two "T" type sliding blocks (19), the "T" type sliding blocks (19) are connected with spring columns A (20), the "T" type sliding blocks (19) are embedded in the "T" type sliding grooves (18), the other end surface of the spring columns A (20) is fixed in the "T" type sliding grooves (18), the partition plate clamping plate (17) penetrates through the clamping plate grooves (15), The water bottle placing groove (3) comprises a downwardly inclined water bottle groove bottom plate (3-1) and a vertically structured water bottle groove sidewall (3-2), a downwardly inclined water bottle communication pipe (24) is connected to the inner end face of the water bottle groove sidewall (3-2), the water bottle (5) is placed on the water bottle groove bottom plate (3-1) and communicates with the water bottle communication pipe (24), a downwardly inclined water flow passage I (32) and a transverse water flow passage II (33) are arranged in the water bottle groove sidewall (3-2), the bottom of the water flow passage I (32) communicates with the water flow passage II (33), the two end water outlets of the water flow passage II (33) are arranged on the outer end face of the water bottle groove sidewall (3-2), the water dispenser I (21) and the water dispenser II (23) respectively communicate with the two end water outlets of the water flow passage II (33), a channel plug recess (34) is arranged on the water flow passage II (33) leading to the water dispenser II (23) side, a threaded groove (35) is arranged on the water bottle groove sidewall (3-2), the channel plug recess (34) and the threaded groove (35) communicate with each other, the water dispenser II valve (37) comprises a "T" type threaded pipe (37-1) and a rubber plug (37-2), the rubber plug (37-2) is bolted to the bottom of the "T" type threaded pipe (37-1), the "T" type threaded pipe (37-1) is screwedly arranged in the threaded groove (35), and the rubber plug (37-2) is embedded in the water flow passage II (33).

2. The SPF level mouse closed colony animal model establishment special EVC cage according to claim 1, characterized in that: A pair of limiting block clamping grooves A (6) are arranged on the left, front and rear inner sidewalls of the EVC cage body (1), a pair of limiting blocks A (7) are connected to the left, front and rear cross beams of the feed trough (4), the limiting blocks A (7) are matched with the limiting block clamping grooves A (6), a sealing strip recess (14) is arranged on the bottom surface of the EVC cage body (1), and a sealing strip (13) is connected to the upper surface of the litter trough (8) and matched with the sealing strip recess (14).

3. The SPF level mouse closed colony animal model establishment special EVC cage according to claim 1, characterized in that: An extrusion column (25) is connected to the water bottle communication pipe (24) through a welding rod, a water outlet pipe (26) is connected to the water bottle (5), a sealing plug clamping ring (27) is fixed in the water outlet pipe (26), a sealing plug (28) is elastically connected to the water outlet pipe (26), opposite connecting rods (30) are connected to the sidewall of the sealing plug (28), opposite connecting rod sliding grooves (29) are arranged on the inner wall of the water outlet pipe (26), spring columns B (31) are fixed in the connecting rod sliding grooves (29), the connecting rods (30) are embedded in the connecting rod sliding grooves (29) and connected with the spring columns B (31), the water outlet pipe (26) is matched with the water bottle communication pipe (24), the extrusion column (25) in the water bottle communication pipe (24) is opposite to the sealing plug (28), and the diameter of the extrusion column (25) is smaller than the inner diameter of the sealing plug clamping ring (27).

4. The SPF level mouse closed colony animal model establishment special EVC cage according to claim 1, characterized in that: The drinking fountain II (23) and the water flow channel II (33) outlet end are connected with drinking fountain II adjusting pipe (22), one end of the drinking fountain II adjusting pipe (22) is fixed on the water bottle groove side wall (3-2) outer end surface, the other end is communicated with the drinking fountain II (23), the drinking fountain II (23) and the drinking fountain II adjusting pipe (22) are connected with two opposite connecting plates (40), one end of the connecting plate (40) is fixed on the drinking fountain II (23), the other end is rotatably connected on the drinking fountain II adjusting pipe (22), the drinking fountain II adjusting pipe (22) side wall is equipped with two opposite pin sliding groove (42), the connecting plate (40) is elastically connected with a limit pin (41), the limit pin (41) inner end surface is embedded in the pin sliding groove (42), the limit pin (41) includes "T" type inner pin (41-1) and pin outer tube (41-2), the pin outer tube (41-2) is fixed on the connecting plate (40) inner end surface, the "T" type inner pin (41-1) penetrates the connecting plate (40) and is embedded in the pin outer tube (41-2), the "T" type inner pin (41-1) and the connecting plate (40) outer end surface are connected with spring column C (48), the "T" type inner pin (41-1) bottom is connected with two pairs of "L" type pressing plate (49), the "L" type pressing plate (49) bottom is arc structure, the pin outer tube (41-2) is connected with washer (50), the pin outer tube (41-2) is equipped with clamping groove ring (51), two pairs of pressing plate sliding groove (52) and two pairs of clamping slot (53), the clamping groove ring (51), two pairs of pressing plate sliding groove (52) and two pairs of clamping slot (53) are sequentially arranged from top to bottom, the "L" type pressing plate (49) penetrates the pressing plate sliding groove (52), and the inner end surface of the vertical section of the "L" type pressing plate (49) is in abutment with the outer wall of the pin outer tube (41-2), the pin outer tube (41-2) is elastically connected with two pairs of arc-shaped fixed plate (54), the arc-shaped fixed plate (54) outer end surface is connected with a pair of spring column D (55) and an arc-shaped clamping (56), the pair of spring column D (55) is fixed on the left and right sides of the arc-shaped clamping (56) respectively, the arc-shaped fixed plate (54) covers the clamping slot (53), the pin sliding groove (42) inner bottom surface and upper surface are provided with opposite clamping groove (47), the arc-shaped clamping (56) penetrates the clamping slot (53) and is embedded in the clamping groove (47).

5. The SPF level mouse closed colony animal model establishment dedicated EVC cage according to claim 4, characterized in that: The water dispenser II adjusting pipe (22) is provided with a sealing ring groove (38) on the outlet end surface, the water dispenser II (23) is connected with a sealing ring (39) on the inlet end surface, the sealing ring (39) is matched with the sealing ring groove (38), the water dispenser II adjusting pipe (22) and the water dispenser II (23) are connected with a pipe plug chain (43), the pipe plug chain (43) comprises two sealing ball plugs (43-1), the two sealing ball plugs (43-1) are connected with plug rods (43-2), the two plug rods (43-2) are connected with a chain (43-3), the water dispenser II adjusting pipe (22) and the water dispenser II (23) are relatively fixed with plug chain fixing ring I (44) and plug chain fixing ring II (45), the plug chain fixing ring II (45) is provided with a plurality of water outlets (46), and the sealing ball plug (43-1) is located between the plug chain fixing ring I (44) and the plug chain fixing ring II (45).

6. The SPF level mouse closed colony animal model establishment special EVC cage according to claim 1, characterized in that: The front and rear sidewalls of the dunnage tank (8) are provided with dunnage tank openings (57), the dunnage tank sidewall baffle (11) is embedded on the dunnage tank opening (57), the right sidewall of the dunnage tank (8) is elastically connected with two baffle clamping blocks (12), the dunnage tank sidewall baffle (11) is of an "L" type structure, the right end surface of the dunnage tank sidewall baffle (11) is provided with a clamping block groove A (58), the baffle clamping block (12) comprises an arc-shaped panel (12-1) and a limiting tube (12-2), the limiting tube (12-2) is fixed at the bottom of the arc-shaped panel (12-1), a spring column E (59) is fixed in the limiting tube (12-2), the right sidewall of the dunnage tank (8) is provided with two limiting tube grooves (60), the limiting tube (12-2) is embedded in the limiting tube groove (60), and the bottom of the spring column E (59) is bolted to the bottom surface of the limiting tube groove (60).

7. The SPF level mouse closed colony animal model establishment special EVC cage according to claim 6, characterized in that: The outer wall of the limiting tube (12-2) is connected with a pair of limiting blocks B (61), the inner wall of the limiting tube groove (60) is provided with a pair of limiting block clamping grooves B (62) and a circular sliding groove (63), the upper end of the limiting block clamping groove B (62) is communicated with the circular sliding groove (63), and the limiting block B (61) is matched with the limiting block clamping groove B (62).

8. The SPF level mouse closed colony animal model establishment special EVC cage according to claim 1, characterized in that: The inside bottom surface of the dunnage chute (8) is fixed with a welding block (64), both ends of the welding block (64) are connected with a rotating shaft (65), the bottom of the dunnage chute partition plate (10) is connected with two rotating shaft sleeves (71), the rotating shaft (65) is sleeved in the rotating shaft sleeve (71), the left and right side walls of the dunnage chute partition plate (10) are elastically connected with two partition plate clamping blocks (67), the two opposite side walls of the partition plate clamping block (67) are connected with a "T" type clamping block adjusting rod (69), the left and right side walls of the dunnage chute partition plate (10) are provided with clamping block grooves B (66), the clamping block grooves B (66) are fixed with spring columns F (68), the front and rear end faces of the dunnage chute partition plate (10) are provided with two adjusting rod sliding grooves (70), the partition plate clamping block (67) is embedded in the clamping block groove B (66), and the partition plate clamping block (67) is connected with the spring column F (68), the "T" type clamping block adjusting rod (69) penetrates through the adjusting rod sliding groove (70), and the left and right inner side walls of the dunnage chute (8) are provided with opposite clamping block limiting grooves (72), and the partition plate clamping block (67) is matched with the clamping block limiting groove (72).

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