A composition, a chewable candy having the efficacy of relieving hangover and protecting the liver, and a preparation method thereof

Abstract

The present invention relates to a composition, a chewable tablet candy having the efficacy of relieving hangover and protecting the liver, and a preparation method thereof, belonging to the technical field of hangover and liver protection products. The composition having the efficacy of relieving hangover and protecting the liver comprises the following raw materials: chicken protein peptide, olive fruit powder, extract of chicken gizzard-membrane, extract of Rosa roxburghii Tratt, extract of Hibiscus sabdariffa Linn, extract of Prunus persica (L.) Batsch, isomaltulose, corn oligopeptide, magnesium stearate, oat β-glucan and γ-aminobutyric acid. By adding olive fruit powder, extract of chicken gizzard-membrane and extract of Rosa roxburghii Tratt, the present invention effectively improves the hangover effect of the chewable tablet candy; by adding extract of Hibiscus sabdariffa Linn and extract of Prunus persica (L.) Batsch, the obtained chewable tablet candy has excellent liver protection effect. In addition, the extract of Prunus persica (L.) Batsch is rich in nicotinic acid, which is beneficial to accelerating the action of olive fruit powder, extract of chicken gizzard-membrane and extract of Rosa roxburghii Tratt, assisting the rapid excretion of alcohol in the body and playing an auxiliary role in relieving hangover; and oat β-glucan effectively speeds up the hangover and liver protection speed of the chewable tablet candy in the body.

Description

Technical Field

[0001] The present invention belongs to the technical field of hangover and liver protection products. Specifically, it relates to a composition, a chewable tablet candy with hangover and liver protection effects, and a preparation method thereof. Background Art

[0002] With the acceleration of the social life rhythm, the negative impact on liver health caused by excessive drinking has become an increasingly serious problem. When the human body ingests alcohol, the liver becomes the main organ responsible for metabolism and detoxification. However, long-term drinking or excessive alcohol consumption can cause liver damage and serious consequences such as alcoholic liver disease. To solve this problem, many products with hangover and liver protection effects have emerged on the market to help people relieve the discomfort caused by drinking and protect liver health. Although there are many such products on the market, their hangover and liver protection effects are still lacking and it is difficult to meet the needs of most people. Therefore, it is particularly necessary to provide a composition and a chewable tablet candy with prominent hangover and liver protection effects. Summary of the Invention

[0003] The purpose of the present invention is to provide a composition, a chewable tablet candy with hangover and liver protection effects, and a preparation method thereof. In the present invention, chicken protein peptide, olive fruit powder, extract of chicken gizzard-membrane and extract of Rosa roxburghii Tratt are added, effectively improving the hangover effect of the chewable tablet candy; extract of Hibiscus sabdariffa Linn and extract of Prunus persica (L.) Batsch are added, making the prepared chewable tablet candy have excellent liver protection effect. In addition, the extract of Prunus persica (L.) Batsch is rich in nicotinic acid, which is beneficial to accelerating the action of olive fruit powder, extract of chicken gizzard-membrane and extract of Rosa roxburghii Tratt, assisting the rapid excretion of alcohol in the body and playing an auxiliary role in hangover; and the oat β-glucan added in the present invention also effectively speeds up the hangover and liver protection speed of the chewable tablet candy in the body, solving the problem of weak hangover and liver protection effects existing in the prior art of hangover and liver protection products.

[0004] The purpose of the present invention can be achieved by the following technical solutions:

[0005] A composition with hangover and liver protection effects, the composition comprises the following raw materials in parts by weight:

[0006]

[0007] As a preferred solution of the present application, the composition with hangover and liver protection effects further comprises 5-9 parts by weight of oat β-glucan and 0.3-0.45 parts by weight of γ-aminobutyric acid.

[0008] As a preferred solution of the present application, the preparation method of the oat β-glucan is:

[0009] A1. Clean the oat raw materials and dry them under temperature control. After drying, break them and sieve them to obtain sieved oat grains;

[0010] A2. Add deionized water to the sieved oat grains, then add the complex enzyme and stir evenly. Then adjust the pH and control the temperature and speed for water bath oscillation extraction to obtain the extract.

[0011] A3. Centrifuge the extract at a controlled speed. After centrifugation is completed, retain the supernatant.

[0012] A4. Add an ethanol solution to the supernatant, let it stand to obtain a blend. Centrifuge the blend at a controlled speed, discard the supernatant, wash the precipitate with the ethanol solution, and then perform vacuum drying to obtain oat β-glucan.

[0013] As a preferred embodiment of the present application, the temperature of the temperature-controlled drying in step A1 is 30 - 35°C, and the time is 1 - 1.5 h; the sieving is through a 20 - 60 mesh sieve.

[0014] As a preferred embodiment of the present application, the mass ratio of the sieved oat grains, deionized water, and complex enzyme in step A2 is 1:2 - 4:0.5 - 0.6; the complex enzyme is composed of alkaline protease and Protease N"Amano" in a mass ratio of 1 - 1.5:0.8 - 1; the pH is 9 - 10; the temperature of the temperature-controlled and speed-controlled water bath oscillation extraction is 53 - 55°C, and the time is 2.5 - 3 h.

[0015] As a preferred embodiment of the present application, the speed of the controlled-speed centrifugation in step A3 is 11500 - 12000 rpm, and the time is 10 - 13 min.

[0016] As a preferred embodiment of the present application, the volume ratio of the supernatant to the ethanol solution in step A4 is 1:7 - 8; the mass concentration of the ethanol solution is 65 - 75%; the standing time is 2 - 3 h; the speed of the controlled-speed centrifugation is 2000 - 3000 rpm, and the time is 10 - 12 min; the number of washing times is 3 - 5 times; the temperature of the vacuum drying is 50 - 55°C.

[0017] As a preferred embodiment of the present application, the preparation method of the composition with the effect of relieving hangover and protecting the liver includes the following steps:

[0018] S1. Granulate chicken protein peptide, olive fruit powder, chicken gizzard extract, rose hip extract, roselle extract, peach kernel extract, and corn oligopeptide with an ethanol solution to obtain intermediate granule A.

[0019] S2. Temperature-controlled dry the intermediate granule A. After drying is completed, add isomaltulose, oat β-glucan, and γ-aminobutyric acid for primary mixing, and then add magnesium stearate for secondary mixing until the color is uniform to obtain intermediate granule B. Measure the moisture content of intermediate granule B, and collect those with a moisture content ≤ 5.0%, which is the composition with the effect of relieving hangover and protecting the liver.

[0020] As a preferred embodiment of the present application, the mass concentration of the ethanol solution in step S1 is 90-95%; the granulation is spray granulation according to a slurry-powder mass ratio of 2-3%, and the wet screening mesh number is 18-20 meshes.

[0021] As a preferred embodiment of the present application, the temperature of the temperature-controlled drying in step S2 is 60-65°C, and the time is 0.5-1 h; the time of the first mixing is 15-20 min; the time of the second mixing is 20-30 min.

[0022] A compressed candy, comprising any one of the above compositions having the efficacy of relieving hangover and protecting the liver.

[0023] As a preferred embodiment of the present application, the preparation method of the compressed candy is: compressing and bottling the composition having the efficacy of relieving hangover and protecting the liver according to 750-830 m parts by weight per tablet to obtain the compressed candy.

[0024] Advantages of the present invention:

[0025] (1) In the present invention, olive fruit powder, extract of chicken gizzard-membrane and extract of Rosa roxburghii Tratt are added, which effectively improves the hangover effect of the compressed candy. This is because the extract of chicken gizzard-membrane can effectively inhibit and delay the absorption of ethanol in alcohol by the digestive tract, strengthen the flow-through effect of ethanol in the gastrointestinal tract, thereby delaying the action time of alcohol and reducing the ethanol concentration in the blood; while the extract of Rosa roxburghii Tratt contains rich substances such as Rosa roxburghii polyphenols, vitamin C, flavonoids, β-sitosterol, etc., and also contains trace elements such as superoxide dismutase (SOD), copper, zinc, iron, selenium, etc., which can effectively enhance the activities of the key alcohol-metabolizing enzymes alcohol dehydrogenase and aldehyde dehydrogenase, improve the ability of the liver to metabolize alcohol, and thus accelerate alcohol metabolism; olives are rich in polyphenols, vitamins, proteins, calcium, iron and other nutrients, which can stimulate liver cells, stimulate liver vitality, promote the regeneration of liver cells, and resist the damage of alcohol to the liver. Therefore, the three work together to improve the hangover effect of the compressed candy by delaying the action time of alcohol, accelerating alcohol metabolism and resisting the damage of alcohol to the liver.

[0026] (2) The chicken protein peptide added in the present invention is rich in amino acids with antioxidant, anti-inflammatory and anti-fibrotic effects, which can reduce the damage of liver cells caused by oxidative stress and inflammation, and thus play a role in protecting liver cells. Secondly, chicken protein peptide can promote the ability of the liver to metabolize alcohol, reduce alcohol metabolites, thereby reducing the burden and damage of the liver, and playing a positive role in relieving hangover and protecting the liver.

[0027] (3) The present invention adds Hibiscus sabdariffa extract and Prunus persica extract, making the prepared chewable tablets have excellent liver protection effects. This is because Hibiscus sabdariffa contains a large amount of glutathione and anthocyanins. Glutathione can effectively counteract the damage of free radicals to the body's organs and tissues, has antioxidant effects, and effectively enhances the detoxification function of liver cells. While Prunus persica extract can promote the degradation of fibronectin, reduce the fibrous septum in the liver caused by alcohol, and repair the liver tissue structure. The two start from the aspects of detoxification and repair, greatly improving the liver protection effect of the chewable tablets. In addition, during the research process of the present invention, it was also found that Prunus persica extract is rich in nicotinic acid, which can promote blood circulation, is beneficial to accelerating the effects of olive fruit powder, Gallus gallus domesticus gizzard-membrane extract and Rosa roxburghii Tratt extract, and helps the alcohol in the body to be quickly excreted, assisting in having the effect of relieving alcohol intoxication.

[0028] (4) The present invention adds oat β-glucan, accelerating the speed of the chewable tablets in relieving alcohol intoxication and protecting the liver in the body. This is because oat β-glucan swells in the intestine, can stimulate the movement of the intestinal wall, promote gastrointestinal peristalsis, and accelerate the passing speed of the chewable tablets. In addition, oat β-glucan can also increase the conversion and production of endogenous bile acids, assist digestion, and then accelerate the digestion of the chewable tablets, prompting them to take effect and accelerating the speed of the chewable tablets in relieving alcohol intoxication and protecting the liver in the body.

[0029] (5) The present invention adds γ-aminobutyric acid, effectively regulating the pH value in the composition, weakening the odor of Gallus gallus domesticus gizzard-membrane extract, and at the same time regulating the sympathetic nerve excitement and increased heart rate caused by alcohol, making the heart rate curve stable.

[0030] (6) The present invention uses alkaline protease and Protease N “Amano” in parts by weight as a complex enzyme, making the yield of the prepared oat β-glucan as high as 13.2% and the purity as high as 89%. Detailed implementation manners

[0031] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0032] The olive fruit powder used in the present invention was purchased from Xi'an Youshuo Biotechnology Co., Ltd.; the extracts of chicken gizzard-membrane and Rosa roxburghii tratt were purchased from Shanyang Lianfeng Biotechnology Co., Ltd.; the extract of Hibiscus sabdariffa was purchased from Fufeng Sinuote Biotechnology Co., Ltd.; the extract of peach kernel was purchased from Nanjing Taigao Phytochemical Co., Ltd.; the alkaline protease was purchased from Nanning Donghenghuadao Biotechnology Co., Ltd.; the Protease N“Amano” in parts by weight was purchased from the Shanghai Branch of Amano Enzyme (Jiangsu) Co., Ltd.

[0033] Example 1

[0034] Prepare oat β-glucan, and the preparation method of the oat β-glucan is as follows:

[0035] A1. Clean the oat raw materials and dry them at 30°C for 1.5 h. After drying, break them and pass through a 40-mesh sieve to obtain sieved oat grains;

[0036] A2. Add deionized water to the sieved oat grains, then add a complex enzyme and stir evenly. Then adjust the pH to 9 and control the temperature at 54°C for water bath oscillation extraction for 2.5 h to obtain an extract;

[0037] The mass ratio of the sieved oat grains, deionized water and the complex enzyme is 1:2:0.5; the complex enzyme is composed of alkaline protease and Protease N“Amano” in a mass ratio of 1.3:0.8;

[0038] A3. Centrifuge the extract at a speed of 11500 rpm for 12 min. After centrifugation, retain the supernatant;

[0039] A4. Add an ethanol solution with a mass concentration of 65% to the supernatant, let it stand for 2.5 h to obtain a blend. Centrifuge the blend at a speed of 2000 rpm for 11 min, discard the supernatant, wash the precipitate 3 times with an ethanol solution with a mass concentration of 75%, and then vacuum dry at 50°C to obtain oat β-glucan;

[0040] The volume ratio of the supernatant to the ethanol solution is 1:7.5.

[0041] After detection, the yield of oat β-glucan is 13.2%, and the purity is 89%.

[0042] Example 2

[0043] Prepare oat β-glucan, and the preparation method of the oat β-glucan is as follows:

[0044] A1. Clean the oat raw materials and dry them at 32°C for 1 h. After drying, break them and pass through a 60-mesh sieve to obtain sieved oat grains;

[0045] A2. Add deionized water to the sieved oat grains, then add the complex enzyme and stir evenly. Then adjust the pH to 10 and control the temperature at 53 °C for water bath oscillation extraction for 3 h to obtain an extract;

[0046] The mass ratio of the sieved oat grains, deionized water and the complex enzyme is 1:2:0.5; the complex enzyme is composed of alkaline protease and Protease N “Amano” in a mass ratio of 1.5:1;

[0047] A3. Centrifuge the extract at a speed of 12000 rpm for 13 min. After centrifugation, retain the supernatant;

[0048] A4. Add an ethanol solution with a mass concentration of 70% to the supernatant, let it stand for 3 h to obtain a blend. Centrifuge the blend at a speed of 3000 rpm for 10 min, discard the supernatant, wash the precipitate 5 times with an ethanol solution with a mass concentration of 65%, and then vacuum dry at 55 °C to obtain oat β-glucan;

[0049] The volume ratio of the supernatant to the ethanol solution is 1:8.

[0050] After detection, the yield of oat β-glucan is 13.0% and the purity is 89%.

[0051] Example 3

[0052] Prepare oat β-glucan, and the preparation method of the oat β-glucan is as follows:

[0053] A1. Wash the oat raw materials clean and dry them at 35 °C for 1.2 h. After drying, break them up and sieve them through a 20-mesh sieve to obtain sieved oat grains;

[0054] A2. Add deionized water to the sieved oat grains, then add the complex enzyme and stir evenly. Then adjust the pH to 10 and control the temperature at 55 °C for water bath oscillation extraction for 2.5 h to obtain an extract;

[0055] The mass ratio of the sieved oat grains, deionized water and the complex enzyme is 1:2:0.6; the complex enzyme is composed of alkaline protease and Protease N “Amano” in a mass ratio of 1:0.9;

[0056] A3. Centrifuge the extract at a speed of 11750 rpm for 10 min. After centrifugation, retain the supernatant;

[0057] A4. Add an ethanol solution with a mass concentration of 75% to the supernatant, let it stand for 2 h to obtain a blend. Centrifuge the blend at a speed of 2500 rpm for 12 min, discard the supernatant, wash the precipitate 4 times with an ethanol solution with a mass concentration of 70%, and then vacuum dry at 53 °C to obtain oat β-glucan;

[0058] The volume ratio of the supernatant to the ethanol solution is 1:7.5.

[0059] After detection, the yield of oat β-glucan is 13.1%, and the purity is 89%.

[0060] Comparative Example 1

[0061] Compared with Example 1, the difference is that step A2 in Comparative Example 1 is as follows: Deionized water is added to the sieved oat grains, and then alkaline protease is added and stirred evenly. Then, the pH is adjusted to 9, and the temperature is controlled at 54 °C for water bath oscillation extraction for 2.5 h to obtain an extract;

[0062] The mass ratio of the sieved oat grains, deionized water, and alkaline protease is 1:2:0.5;

[0063] The remaining operation steps and parameters remain unchanged.

[0064] After detection, the yield of oat β-glucan is 8.7%, and the purity is 79%.

[0065] Comparative Example 2

[0066] Compared with Example 1, the difference is that step A2 in Comparative Example 2 is as follows: Deionized water is added to the sieved oat grains, and then Protease N “Amano” parts by weight are added and stirred evenly. Then, the pH is adjusted to 9, and the temperature is controlled at 54 °C for water bath oscillation extraction for 2.5 h to obtain an extract;

[0067] The mass ratio of the sieved oat grains, deionized water, and Protease N “Amano” parts by weight is 1:2:0.5;

[0068] The remaining operation steps and parameters remain unchanged.

[0069] After detection, the yield of oat β-glucan is 9.1%, and the purity is 81%.

[0070] Example 4

[0071] A composition with the efficacy of relieving hangover and protecting the liver, the composition comprising the following raw materials in parts by weight:

[0072]

[0073] The preparation method of the composition comprises the following steps:

[0074] S1. Spray granulation of chicken protein peptide, olive fruit powder, chicken gizzard extract, rose hip extract, roselle extract, peach kernel extract, and corn oligopeptide with an ethanol solution with a mass concentration of 90% according to a slurry-to-powder mass ratio of 2.5%, and the wet screening mesh number is 18 meshes to obtain intermediate granule A;

[0075] S2. Control the temperature of the intermediate granule A at 65 °C and dry it for 0.5 h. After drying, add isomaltitol, the oat β-glucan prepared in Example 2, and γ-aminobutyric acid and mix for 18 min. Then add magnesium stearate and mix for 30 min until the color is uniform to obtain the intermediate granule B. Measure the moisture content of the intermediate granule B, and collect those with a moisture content ≤ 5.0%, which is the composition with the effect of relieving hangover and protecting the liver.

[0076] Press the composition into tablets at 830 m parts by weight per tablet and bottle it to obtain the chewable tablets.

[0077] Smelled by the operator, the chewable tablets prepared in this example have no peculiar smell.

[0078] Example 5

[0079] A composition with the effect of relieving hangover and protecting the liver, and the composition comprises the following raw materials in parts by weight:

[0080]

[0081] The preparation method of the composition comprises the following steps:

[0082] S1. Spray granulate chicken protein peptide, olive fruit powder, chicken gizzard extract, rosa roxbunghii tratt extract, hibiscus sabdariffa extract, peach kernel extract, and corn oligopeptide with an ethanol solution with a mass concentration of 93% according to a slurry-to-powder mass ratio of 2%. The wet screening mesh number is 20 meshes to obtain the intermediate granule A;

[0083] S2. Control the temperature of the intermediate granule A at 60 °C and dry it for 1 h. After drying, add isomaltitol, the oat β-glucan prepared in Example 3, and γ-aminobutyric acid and mix for 20 min. Then add magnesium stearate and mix for 25 min until the color is uniform to obtain the intermediate granule B. Measure the moisture content of the intermediate granule B, and collect those with a moisture content ≤ 5.0%, which is the composition with the effect of relieving hangover and protecting the liver.

[0084] Press the composition into tablets at 750 m parts by weight per tablet and bottle it to obtain the chewable tablets.

[0085] Smelled by the operator, the chewable tablets prepared in this example have no peculiar smell.

[0086] Example 6

[0087] A composition with the effect of relieving hangover and protecting the liver, and the composition comprises the following raw materials in parts by weight:

[0088]

[0089] The preparation method of the composition comprises the following steps:

[0090] S1. Spray granulation is carried out on chicken protein peptide, olive fruit powder, chicken gizzard extract, rose roxburghii extract, roselle extract, peach kernel extract and corn oligopeptide with an ethanol solution with a mass concentration of 95% according to a slurry powder mass ratio of 3%, and the wet granulation mesh number is 18 meshes to obtain intermediate granule A;

[0091] S2. Dry the intermediate granule A at a controlled temperature of 63°C for 1 h. After drying, add isomaltitol, the oat β-glucan prepared in Example 1 and γ-aminobutyric acid and mix for 15 min, and then add magnesium stearate and mix for 20 min until the color is uniform to obtain intermediate granule B. Measure the moisture content of intermediate granule B, and collect those with a moisture content ≤ 5.0%, which is the anti-alcoholism and liver-protecting efficacy composition.

[0092] Tablet the composition at 790 m parts by weight per tablet and bottle it to obtain the tablet candy.

[0093] After smelling by the operator, the tablet candy prepared in this example has no peculiar smell.

[0094] Comparative Examples 3-5

[0095] Compared with Example 6, the difference is that the masses of olive fruit powder, chicken gizzard extract and rose roxburghii extract in Comparative Examples 3-5 are shown in Table 1, and the rest of the operation steps and parameters remain unchanged.

[0096] Table 1

[0097] Olive fruit powder (parts by weight) Extract of chicken gizzard-membrane (parts by weight) Extract of Rosa roxburghii tratt (parts by weight) Comparative Example 3 0 13 36 Comparative Example 4 17 0 32 Comparative Example 5 29 20 0

[0098] Comparative Examples 6-7

[0099] Compared with Example 6, the difference is that the masses of roselle extract and peach kernel extract in Comparative Examples 6-7 are shown in Table 2, and the rest of the operation steps and parameters remain unchanged.

[0100] Table 2

[0101] Extract of Hibiscus sabdariffa Linn (parts by weight) Extract of Prunus persica (L.) Batsch (parts by weight) Comparative Example 6 0 43 Comparative Example 7 43 0

[0102] Comparative Example 8

[0103] Compared with Example 6, the difference is that the oat β-glucan prepared in Example 1 is not added in Comparative Example 8, and the rest of the operation steps and parameters remain unchanged.

[0104] Comparative Example 9

[0105] Compared with Example 6, the difference in Comparative Example 9 is that the oat β-glucan prepared in Example 1 in Example 6 is replaced with the oat β-glucan prepared in Comparative Example 1, and the rest of the operation steps and parameters remain unchanged.

[0106] Comparative Example 10

[0107] Compared with Example 6, the difference in Comparative Example 10 is that the oat β-glucan prepared in Example 1 of Example 6 is replaced with the oat β-glucan prepared in Comparative Example 2, and the remaining operation steps and parameters remain unchanged.

[0108] Comparative Example 11

[0109] Compared with Example 6, the difference is that γ-aminobutyric acid is not added in Comparative Example 11, and the remaining operation steps and parameters remain unchanged.

[0110] After being smelled by the operator, the tablet candy prepared in this comparative example has a stench.

[0111] Test Example 1

[0112] Select 80 SPF-grade SD rats with a weight of 180-190 parts by weight, half male and half female. Randomly divide them into 10 groups and label them as groups 1-10, with 8 rats in each group; transfer the 10 groups of rats to the animal house for adaptive cultivation. The animals normally ingest feed, and the cultivation period is 3 days. After the cultivation is completed, use 75% food-grade anhydrous ethanol according to the standard of 15 mL / kg, and adopt the single gavage method to construct an acute alcoholism animal model of rats. After the construction, the rats show symptoms such as unsteady gait, slow movement, dragging the hind abdomen, urinary incontinence, lying on the side, disappearance of the righting reflex, and lethargy, indicating that the acute alcoholism model of mice is successfully constructed. 0.5 h after the construction is completed, each group of rats is fed with medicine at different doses. Specifically, the compositions prepared in Examples 4-6 and Comparative Examples 3-5, Comparative Examples 7-10 and deionized water are mixed until just dissolved, and then the rats in groups 1-10 are respectively fed, so as to observe the sobering time and sleeping time of each group of rats;

[0113] (1) Sobering time: The drunkenness of the rats is judged by the disappearance of their righting reflex. When in a drunken state, if the back of the rat is downward for more than 30 seconds, it indicates the disappearance of the righting reflex; if the back of the rat is downward for less than 30 seconds, it indicates that it can move freely, and the righting reflex is considered to have recovered.

[0114] (2) Sleeping time: The time from when the rats are drunk and asleep to when they are awake.

[0115] The results are shown in Table 3.

[0116] Table 3

[0117] Sobering time (min) Sleeping time (min) Example 4 119±2 110±2 Example 5 121±3 111±2 Example 6 118±2 108±2 Comparative Example 3 132±3 123±3 Comparative Example 4 135±3 126±2 Comparative Example 5 141±2 130±3 Comparative Example 7 130±2 122±2 Comparative Example 8 136±3 128±2 Comparative Example 9 138±3 129±2 Comparative Example 10 139±3 130±2

[0118] As can be seen from Examples 4-6 and Comparative Examples 3-5 in Table 3, the present invention adds olive fruit powder, extract of chicken gizzard-membrane and extract of Rosa roxburghii tratt, effectively improving the anti-alcohol effect of the chewable tablets; from Comparative Example 7, it can be seen that peach kernel extract is added. Peach kernel extract is rich in nicotinic acid, which can promote blood circulation, facilitate the action of olive fruit powder, extract of chicken gizzard-membrane and extract of Rosa roxburghii tratt, assist the rapid excretion of alcohol from the body, and play an auxiliary role in relieving alcoholism; from Comparative Examples 8-10, it can be seen that adding oat β-glucan speeds up the speed of the chewable tablets in relieving alcohol and protecting the liver in the body.

[0119] Test Example 2

[0120] Select 64 SD rats of SPF grade, with half male and half female, weighing 180-190 parts by weight. Randomly divide them into 8 groups and label them as the 1st to 8th groups, with 8 rats in each group; transfer the 8 groups of rats to the animal house for adaptive cultivation. The animals normally ingest feed, and the cultivation period is 3 days. After the cultivation is completed, according to the standard of 15 mL / kg of 75% food-grade anhydrous ethanol, use the single gavage method to construct an acute alcohol poisoning animal model of rats. After the construction, the rats show symptoms such as unsteady gait, slow movement, dragging the hind abdomen, urinary incontinence, lying on the side, disappearance of the righting reflex, and lethargy, indicating that the acute alcohol poisoning model of mice is successfully constructed. 0.5 h after the construction is completed, each group of rats is fed medicine according to different doses. Mix the compositions prepared in Examples 4-6 and Comparative Examples 6-10 with deionized water until just dissolved. 3.0 h after the acute alcohol poisoning of the rats, after sacrificing each group of rats, take the orbital venous blood, liver and stomach of the rats. Fix the rats, place a 1 mm capillary glass tube in the rat's eyeball, rotate to take venous blood, place the blood in a test tube and centrifuge at 3000 r / min for 15 min, take the serum, and transfer it to -20 °C for storage for later use. Take the liver and stomach, rinse them clean with normal saline respectively, add normal saline and homogenize them respectively, and transfer them to -20 °C for storage for later use.

[0121] Detect the ethanol dehydrogenase (ADH), superoxide dismutase (SOD) and malondialdehyde (MDA) indexes of the rats in the 1st to 8th groups in this way, and the above detections are strictly carried out according to the methods of the reagent kits for each index.

[0122] Data processing: The experimental data are expressed as "mean ± standard deviation", and the single-factor analysis of variance with completely randomized design is carried out using SPSS19.0 software. The results are shown in Table 4.

[0123] Table 4

[0124] Ethanol dehydrogenase (mol / L) Superoxide dismutase (mol / L) Malondialdehyde (mol / L) Example 4 14.48±1.91 84.73±3.03 2.681±0.0149 Example 5 15.02±1.92 84.91±3.09 2.646±0.0127 Example 6 15.13±1.94 84.99±3.11 2.602±0.0114 Comparative Example 6 9.75±1.70 63.87±1.55 3.201±0.0196 Comparative Example 7 9.91±1.63 64.12±1.28 3.102±0.0191 Comparative Example 8 10.38±1.23 68.04±1.25 2.996±0.0184 Comparative Example 9 12.52±1.96 74.04±1.47 2.879±0.0182 Comparative Example 10 12.92±1.72 77.37±1.36 2.833±0.0190

[0125] As shown in Table 4, the present invention adds Hibiscus sabdariffa extract and Prunus persica extract, making the prepared chewable tablets have excellent liver protection effects; moreover, adding oat β-glucan speeds up the speed of the chewable tablets to relieve alcohol and protect the liver in the body.

[0126] In the description of the specification, the descriptions referring to terms such as "one embodiment", "example", "specific example", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0127] The above content is only an example and explanation of the present invention. Those skilled in the art of the present technology can make various modifications or supplements to the described specific embodiments or use similar ways to replace them. As long as they do not deviate from the invention or exceed the scope defined by the claims of the present invention, they should all belong to the protection scope of the present invention.

Claims

1. A composition with the efficacy of relieving hangover and protecting the liver, characterized in that, The composition comprises the following raw materials in parts by weight: Chicken protein peptide: 30 - 40 parts by weight Olive fruit powder: 9 - 14 parts by weight Extract of chicken gizzard-membrane: 4 - 7 parts by weight Extract of Rosa roxburghii tratt: 23 - 36 parts by weight Extract of Hibiscus sabdariffa Linn: 13 - 25 parts by weight Extract of peach kernel: 10 - 18 parts by weight Isomaltitol: 25 - 35 parts by weight Corn oligopeptide: 15 - 25 parts by weight Magnesium stearate: 1 - 2 parts by weight; The composition with the efficacy of relieving hangover and protecting liver further comprises 5 - 9 parts by weight of oat β-glucan and 0.3 - 0.45 parts by weight of γ-aminobutyric acid; The preparation method of the oat β-glucan is as follows: A1. Clean the oat raw materials and dry them under controlled temperature. After drying, break them and sieve them to obtain sieved oat grains; A2. Add deionized water to the sieved oat grains, then add a composite enzyme and stir evenly. Then adjust the pH and carry out water bath oscillation extraction under controlled temperature and speed to obtain an extract; A3. Centrifuge the extract under controlled speed. After centrifugation, retain the supernatant; A4. Add an ethanol solution to the supernatant, let it stand to obtain a blend. Centrifuge the blend under controlled speed, discard the supernatant, wash the precipitate with the ethanol solution, and then carry out vacuum drying to obtain oat β-glucan; The composite enzyme is composed of alkaline protease and Protease N"Amano" in a mass ratio of 1 - 1.5:0.8 - 1.

2. The composition with the efficacy of relieving hangover and protecting the liver according to claim 1, wherein In step A1, the temperature of the controlled-temperature drying is 30 - 35°C, and the time is 1 - 1.5 h; the sieving is through a 20 - 60 mesh sieve; in step A2, the mass ratio of the sieved oat grains, deionized water and the composite enzyme is 1:2 - 4:0.5 - 0.6; the pH is 9 - 10; the temperature of the water bath oscillation extraction under controlled temperature and speed is 53 - 55°C, and the time is 2.5 - 3 h.

3. The composition with the effect of relieving hangover and protecting the liver according to claim 1, characterized in that, In step A3, the speed of the controlled-speed centrifugation is 11500 - 12000 rpm, and the time is 10 - 13 min; in step A4, the volume ratio of the supernatant to the ethanol solution is 1:7 - 8; the mass concentration of the ethanol solution is 65 - 75%; the standing time is 2 - 3 h; the speed of the controlled-speed centrifugation is 2000 - 3000 rpm, and the time is 10 - 12 min; the number of washing times is 3 - 5 times; the temperature of the vacuum drying is 50 - 55°C.

4. A preparation method of a composition with the efficacy of relieving hangover and protecting the liver as described in any one of claims 1-3, characterized in that, The preparation method of the composition with the efficacy of relieving hangover and protecting liver comprises the following steps: S1. Granulate chicken protein peptide, olive fruit powder, extract of chicken gizzard-membrane, extract of Rosa roxburghii tratt, extract of Hibiscus sabdariffa Linn, extract of peach kernel and corn oligopeptide with an ethanol solution to obtain intermediate granule A; S2. Dry the intermediate granule A under controlled temperature. After drying, add isomaltitol, oat β-glucan and γ-aminobutyric acid for primary mixing, and then add magnesium stearate for secondary mixing until the color is uniform to obtain intermediate granule B. Measure the moisture content of the intermediate granule B, and collect the intermediate granule B with a moisture content ≤ 5.0%, which is the composition with the efficacy of relieving hangover and protecting liver.

5. The preparation method of a composition with the efficacy of relieving hangover and protecting the liver according to claim 4, characterized in that, In step S1, the mass concentration of the ethanol solution is 90 - 95%; the granulation is spray granulation according to a slurry-powder mass ratio of 2 - 3%, and the wet screening mesh number is 18 - 20 mesh.

6. The preparation method of a composition with the efficacy of relieving hangover and protecting the liver according to claim 4, characterized in that, The temperature of the temperature-controlled drying described in step S2 is 60-65°C, and the time is 0.5-1 h; the time of the primary mixing is 15-20 min; the time of the secondary mixing is 20-30 min.

7. A tablet candy, characterized in that, It includes the composition with the effect of relieving hangover and protecting the liver as described in any one of claims 1-3.

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