Automatic injection device for batch mouse drug test

Abstract

This invention discloses an automated injection device for batch mouse drug testing, comprising a base, an experimental box, a rotary mouse trapping and fixing mechanism, an injection mechanism, and an observation box. A support frame is mounted on the base, the experimental box is positioned above the support frame, and the observation box is located on the base. The rotary mouse trapping and fixing mechanism is located on the base, with its head and tail connected to the experimental box and observation box, respectively. The injection mechanism is located on the base and on one side of the rotary mouse trapping and fixing mechanism. This invention belongs to the technical field of mouse drug injection equipment, specifically providing an automated injection device for batch mouse drug testing that automatically traps and self-fixes mice individually for convenient tail vein injection, and automatically transfers the mice into the observation box after injection.

Description

Technical Field

[0001] This invention belongs to the technical field of mouse drug injection equipment, specifically relating to an automated injection device for batch mouse drug testing. Background Technology

[0002] To verify the therapeutic effects of drugs, drug experiments are often conducted on small animals, primarily mice. Tail vein injection in mice is a commonly used injection method in pharmacological, toxicological, and efficacy studies, and is also an essential skill in medical research. However, due to the active nature of mice and the thinness of their tail veins, tail vein injection is quite difficult. Therefore, mice need to be captured and restrained in a restraint to facilitate injection. However, there is a risk of mouse escape during both the capture and restraint processes.

[0003] Current drug trials, in order to verify the therapeutic effect of drugs, often require batch comparative experiments on multiple mice. When administering tail vein injections to batches of mice, the manual capture and fixation of the mice is a cumbersome, labor-intensive, and time-consuming procedure. Although there are existing devices for automated injection of large numbers of mice, most of them use intraperitoneal injection and lack automated tail vein injection equipment for batches of mice. Summary of the Invention

[0004] In order to overcome the shortcomings of the prior art, the present invention provides an automated injection device for batch mouse drug testing that automatically traps and adaptively fixes mice one by one, facilitates tail vein injection, and automatically transfers the mice into an observation box after injection.

[0005] The technical solution adopted by this invention is as follows: This invention provides an automated injection device for batch mouse drug testing, comprising a base, an experimental box, a rotary mouse trapping and fixing mechanism, an injection mechanism, and an observation box. A support frame is provided on the base, the experimental box is located above the support frame, the observation box is located on the base, and the rotary mouse trapping and fixing mechanism is located on the base. The first and second ends of the rotary mouse trapping and fixing mechanism are respectively connected to the experimental box and the observation box. The injection mechanism is located on the base and on one side of the rotary mouse trapping and fixing mechanism. The rotary mouse trapping and fixing mechanism includes a fixing frame, an attraction channel, a trapping rotary frame, a one-way mouse fixing cage, and an output channel. The fixing frame is located on the base, and a fixing mesh is fixedly connected to the side wall of the fixing frame. The trapping rotary frame is coaxially rotatably mounted on the side wall of the fixing mesh. A Geneva actuator is provided on the side wall of the fixing frame to drive the trapping rotary frame to rotate intermittently. The one-way mouse fixing cage rotates through the trapping rotary frame and rotates around the trapping rotary frame. The unidirectional mouse cage is arranged in a circular array along the axis. Both ends of the cage are hollow. The sidewalls of the cage have multiple sets of axial mesh holes. One end of the cage is tightly fitted to the fixed mesh tray, and the other end has a rotatable cage door. The attraction channel is located at the bottom of the sidewall of the experimental chamber and intermittently connects with the cage. The sidewall of the fixed mesh tray has an output opening. One end of the output channel is connected to the output opening, and the other end is located above the observation box. The sidewall of the fixed mesh tray has a trap box containing trapping material. The trapping material attracts the mice in the experimental chamber. The mice enter the cage along the attraction channel and are then intermittently rotated by the trapping turntable under the drive of the Geneva actuator, facilitating tail vein injection. When the cage rotates to the injection mechanism, the mice are injected via the tail vein. The cage then continues to rotate to the output opening and is sent into the observation box through the output opening and output channel.

[0006] As a further improvement to this solution, the bottom wall of the mouse unidirectional fixation cage is provided with a weight-increasing block. The weight-increasing block facilitates the automatic adjustment of the angle of the mouse unidirectional fixation cage as it rotates with the trapping turntable, thereby ensuring that the mouse unidirectional fixation cage always remains vertical, improving the stability of the device, and avoiding discomfort to the mice caused by the rotation of the trapping turntable. The trapping box is hollow at both ends. One end of the trapping box is located on the side wall of the fixed net tray, and the end of the trapping box away from the fixed net tray is threaded with an end cap, which facilitates the replacement of the trapping material.

[0007] The mouse one-way fixation cage has fixed flanges at both ends, and door holes are provided on the fixed flanges. A door hinge is rotatably inserted through the door hole, and the cage door is fixedly connected to the door hinge. A reset cavity is provided on the side wall of the mouse one-way fixation cage. The door hinge rotatably inserts through the reset cavity. A coil spring is provided in the reset cavity. One end of the coil spring is connected to the door hinge, and the other end of the coil spring is connected to the inner wall of the reset cavity. When the cage door is offset from the end of the mouse one-way fixation cage, the coil spring can easily drive the cage door to reset and close the mouse one-way fixation cage, preventing the mouse from escaping.

[0008] To prevent the mouse from retreating, the one-way cage for mice is equipped with a circumferential array of one-way hinges on its sidewall. Each one-way hinge rotates within an axial mesh opening, within which a limiting plate is positioned. This limiting plate is located close to the upper end of each one-way hinge on the side furthest from the cage door. The limiting plates are arranged in a circumferential array around the one-way cage, corresponding to the one-way hinges. A return spring is provided between the one-way hinges and the cage. The multiple one-way hinges form a circular through-hole. The return spring pulls the one-way hinges close to the mouse's body, ensuring the circular through-hole allows the mouse to pass through. Once the mouse passes through the through-hole, the limiting plate prevents the hinges from rotating backward, thus preventing the mouse from exiting the cage.

[0009] Preferably, the cage door has an annular protrusion on the side away from the mouse unidirectional fixation cage. The length of the annular protrusion is greater than the length from the end of the attraction channel to the end of the mouse unidirectional fixation cage. Thus, when the mouse unidirectional fixation cage rotates to the attraction channel, the attraction channel pushes the cage door to rotate through the annular protrusion, thereby opening the cage door so that the attraction channel and the mouse unidirectional fixation cage are aligned and connected. The bottom wall of the cage door has an avoidance notch, and the edge of the avoidance notch extends upward to a human-shaped hole. The avoidance notch and the human-shaped hole facilitate the mouse tail to be exposed from the mouse unidirectional fixation cage. The side wall of the fixed net tray has an annular extension plate, and the end of the annular extension plate has a fan-shaped plate. The trapping turntable is rotatably positioned between the fan-shaped plate and the fixed net tray. The side of the fan-shaped plate near the trapping turntable is equipped with an infrared heating lamp, which heats the mouse tail to facilitate the dilation of veins.

[0010] To facilitate the fixation of mice of different sizes, the trapping turntable includes a rotating shaft, a first turntable, and a second turntable. The rotating shaft is coaxially rotatable on the side wall of the fixing mesh tray. The first and second turntables are coaxially fixed to the rotating shaft. The first turntable has a first rotating hole arranged in a circumferential array around the rotating shaft, and the second turntable has a second rotating hole arranged in a circumferential array around the rotating shaft. The first and second rotating holes correspond one-to-one and are coaxially aligned. A fixing flange is rotatably disposed within the second rotating hole. A connecting rod is provided between the fixing flanges at both ends of the mouse unidirectional fixation cage. A through-hole limiting rotating hole is provided in the middle of the mouse unidirectional fixation cage. A limiting component is fixedly connected to the door hinge and rotatably disposed within the limiting rotating hole. The limiting component includes a limiting sleeve, a limiting disk, and a limiting tension spring. The side wall of the limiting sleeve has a protrusion that is fixedly connected to the door hinge. The limiting sleeve is open on one side. The limiting disk is slidably disposed within the limiting sleeve, and a limiting spring is disposed between the limiting disk and the limiting sleeve. The limiting spring causes the limiting disk to tend to move closer to the limiting sleeve. The limiting disk, the limiting sleeve, and the cage door are arranged coaxially. A fan-shaped magnetic block is provided on the side wall of the fixed mesh disk away from the trap turntable frame. The magnetic poles of the fan-shaped magnetic block and the adjacent side of the limiting disk are the same. Thus, when the limiting disk rotates to the fan-shaped magnetic block, the fan-shaped magnetic block generates a magnetic repulsion force on the limiting disk. The magnetic repulsion force is greater than the elastic force of the limiting spring. The magnetic repulsion force causes the limiting disk to overcome the elastic force of the limiting spring, extend out of the limiting sleeve, and move along the mouse unidirectional fixing cage to adaptively fix and limit the mouse. The fan-shaped magnetic block is arranged coaxially with the trap turntable frame and is located on the side away from the trap box and the output opening. When the limiting disk rotates to the trap box or the output opening, the limiting disk retracts into the limiting sleeve under the elastic force of the limiting spring.

[0011] Preferably, ventilation holes are provided on the limiting disk and the limiting sleeve, and a flexible sponge layer is wrapped on the side wall of the limiting disk away from the limiting sleeve to achieve adaptive and non-destructive fixation and limiting of the mouse.

[0012] Preferably, the trap box is aligned with the axis of the attraction channel, and the length from the axis of the attraction channel to the axis of the trap turntable is equal to the length from the axis of the mouse one-way fixed cage to the axis of the trap turntable, so that when the attraction channel is connected to the mouse one-way fixed cage, the attraction channel, the mouse one-way fixed cage and the trap box are arranged on the same axis.

[0013] The fixture has a drive cavity on its side wall. The Geneva actuator includes a geared motor, a drive wheel, and a driven grooved wheel. The drive wheel and driven grooved wheel are rotatably mounted in the drive cavity. The geared motor is located on the side wall of the drive cavity, and its output shaft is coaxially fixed to the drive wheel. The driven grooved wheel has multiple radial grooves and multiple concave arc grooves arranged in a circumferential array on its side wall, with the radial grooves and concave arc grooves spaced apart. A pin and a blocking disc are provided on one side wall of the drive wheel. The pin is eccentrically mounted on the side wall of the drive wheel and can extend into the radial groove, driving the driven grooved wheel to rotate intermittently with equal amplitude. The blocking disc is coaxially fixed to the side wall of the drive wheel and includes a concave arc segment and a convex arc segment. The number of radial grooves is equal to the number of mouse unidirectional fixation cages, both being N. The driven grooved wheel is coaxially fixed to the trapping turntable. The geared motor drives the drive wheel to rotate slowly. When the drive wheel rotates one revolution, the driven grooved wheel rotates 360 / N° via the pin, achieving intermittent equal amplitude rotation, which facilitates mouse trapping, injection, and output.

[0014] Further, the injection mechanism includes an upward-pushing electric plunger, a V-shaped fixing seat, a downward-moving electric plunger, and a tensioning seat. The upward-pushing electric plunger is located on the upper wall of the base. The V-shaped fixing seat is located at the upper end of the upward-pushing electric plunger and is located on one side of the trapping turntable. The length of the V-shaped fixing seat to the end of the mouse's one-way fixing cage is slightly less than the length of the annular protrusion. The upper wall of the V-shaped fixing seat has a V-shaped positioning groove, which cooperates with the human-shaped hole to facilitate positioning of the mouse's tail. The downward-moving electric plunger is located on the base on the side of the upward-pushing electric plunger away from the trapping turntable. The tensioning seat is located on the downward-moving electric plunger. Semi-cylindrical elastic protrusions are arranged in an array on the side wall of the tensioning seat. Initially, the height of the tensioning seat is greater than that of the V-shaped fixing seat. When injecting a mouse, the upward-pushing electric plunger moves the V-shaped fixing seat upward, bringing it closer to the upper end of the human-shaped hole. The downward-moving electric plunger moves the tensioning seat downward, and the elastic protrusion pulls the mouse's tail downward, thus tensioning and fixing the mouse's tail at the bottom of the middle of the V-shaped positioning groove. A cold light is installed in the V-shaped positioning groove. The tensioning seat has a guide cylinder that runs through it from front to back. The end of the guide cylinder has a limiting flange. A sliding sleeve is fitted on the outside of the guide cylinder. A spring is installed between the sliding sleeve and the limiting flange. The guide cylinder facilitates the guidance of the syringe for precise injection.

[0015] Preferably, the side wall of the support frame is provided with a pushing assembly, which is attached to the end of the mouse unidirectional fixation cage. The pushing assembly includes a pushing cylinder, a horizontal pushing electric rod, and a pushing disk. The pushing cylinder is located on the side wall of the support frame, and the side of the pushing cylinder near the mouse unidirectional fixation cage is hollow. The pushing cylinder is coaxial with the output opening. The horizontal pushing electric rod is located inside the pushing cylinder, and the pushing disk is located on the side of the horizontal pushing electric rod near the mouse unidirectional fixation cage. The pushing disk has circumferentially arranged avoidance grooves aligned with the unidirectional hinge rod, which avoid the unidirectional hinge rod. The pushing cylinder is located diagonally below the attraction channel. The length from the end of the pushing cylinder to the end of the mouse unidirectional fixation cage is less than the length of the annular protrusion. The length from the axis of the pushing cylinder to the axis of the trapping turntable is equal to the length from the axis of the mouse unidirectional fixation cage to the axis of the trapping turntable. When the mouse unidirectional fixation cage rotates and approaches the pushing cylinder, the pushing cylinder pushes the cage door to rotate and avoid it through the annular protrusion, thereby facilitating the alignment and communication between the pushing cylinder and the mouse unidirectional fixation cage.

[0016] The diameter of the attraction channel and the diameter of the mouse unidirectional fixation cage are greater than 2.5 cm and less than 4.5 cm, so that only one mouse can pass through the attraction channel and the mouse unidirectional fixation cage at the same time. The base is equipped with a controller, which is electrically connected to the geared motor, the horizontal push electric push rod, the upward push electric push rod, the downward movement electric push rod, and the infrared heating lamp.

[0017] The beneficial effects achieved by the present invention using the above structure are as follows:

[0018] 1. By setting up a trap box in conjunction with an attraction channel, a trapping turntable, and a one-way mouse restraint cage, mice can be individually trapped and restrained. The one-way mouse restraint cage, output channel, and pusher components work together to achieve automated output of injected mice. This high degree of automation significantly reduces the pre-injection restraint preparation work required for mouse tail vein injection.

[0019] 2. By setting fan-shaped magnetic blocks at specific positions on the side wall of the fixed mesh disk, the magnetic repulsion force drives the limiting disk to move in the unidirectional fixation cage of the mouse, thereby achieving non-destructive adaptive fixation of the mouse. At the same time, the limiting component moves synchronously with the cage door through the door hinge, thereby ensuring the passage of the unidirectional fixation cage of the mouse when the cage door is opened.

[0020] 3. With the help of the ring protrusion and the coil spring, the cage door will automatically open when the mouse unidirectional fixation cage rotates to the attraction channel or the push component, ensuring the connection between the mouse unidirectional fixation cage and the attraction channel, as well as between the mouse unidirectional fixation cage and the output channel. Together with the fixation net and the trap turntable, it forms an automated production line for capture, fixation, injection and output.

[0021] 4. An avoidance notch and a human-shaped hole are set in the cage door, and with the upward-moving V-shaped fixing seat and the downward-moving tensioning seat, the mice can be automatically fixed and tensioned, which makes it convenient for the experimenters to inject drugs.

[0022] 5. A guide tube is provided to facilitate precise injection of the drug by the experimenter, and an infrared lamp is used to preheat the tail of the mouse.

[0023] 6. The Geneva actuator drives the trapping turntable to rotate intermittently, thereby realizing the periodic work of automated mouse trapping, fixation and injection, which facilitates the injection of batches of mice and greatly reduces labor intensity. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the structure of an automated injection device for batch mouse drug testing provided by the present invention;

[0025] Figure 2 This is a schematic diagram of the rotating mouse trapping and restraining mechanism provided by the present invention;

[0026] Figure 3 This is a schematic diagram of the rotating mouse trapping and restraining mechanism provided by the present invention from another perspective.

[0027] Figure 4 A schematic diagram of the combined structure of the trapping turntable, the mouse one-way fixing cage, the attraction channel, the output channel and the pushing component provided by the present invention;

[0028] Figure 5 A schematic diagram showing the open state of the cage door of the unidirectional mouse fixation cage provided by the present invention;

[0029] Figure 6 A schematic diagram of the closed state of the cage door of the unidirectional mouse fixation cage provided by the present invention;

[0030] Figure 7 This is a schematic diagram of the structure of the unidirectional mouse fixation cage provided by the present invention;

[0031] Figure 8 A schematic diagram of the combined structure of the cage door, door hinge, and limiting assembly provided by the present invention;

[0032] Figure 9 A schematic diagram of the structure of the fixed mesh disk, the annular extension plate, and the fan-shaped disk provided by the present invention;

[0033] Figure 10 This is a schematic diagram of the push component provided by the present invention;

[0034] Figure 11 This is a schematic diagram of the injection mechanism and base provided by the present invention;

[0035] Figure 12This is a schematic diagram of the structure of the guide cylinder and sliding sleeve provided by the present invention;

[0036] Figure 13 A schematic diagram of the internal structure of the Geneva drive provided by the present invention.

[0037] The components include: 1. Base; 2. Experiment box; 3. Rotary mouse trapping and fixing mechanism; 4. Injection mechanism; 5. Observation box; 6. Support frame; 7. Fixing frame; 8. Lure channel; 9. Trapping turntable frame; 10. One-way mouse fixing cage; 11. Output channel; 12. Fixing mesh; 13. Geneva actuator; 14. Axial mesh; 15. Cage door; 16. Output opening; 17. Trapping box; 18. Radial groove; 19. Weight block; 20. End cap; 21. Fixing flange; 22. Door hole; 23. Door hinge; 24. Reset cavity; 25. Blocking plate; 26. One-way hinge; 27. Limiting plate; 28. Reset tension spring; 29. ​​Annular protrusion; 30. Clearance notch; 31. Human-shaped hole; 32. Annular extension plate; 33. Fan-shaped plate; 34. Infrared lamp. 5. Rotating shaft; 36. First turntable; 37. Second turntable; 38. First rotating hole; 39. Second rotating hole; 40. Connecting rod; 41. Limiting rotating hole; 42. Limiting assembly; 43. Limiting sleeve; 44. Limiting disk; 45. Limiting tension spring; 46. Sector-shaped magnetic block; 47. Ventilation hole; 48. Drive chamber; 49. Pin shaft; 50. Gear motor; 51. Driving wheel; 52. Driven grooved wheel; 53. Upward push electric actuator; 54. V-shaped fixed seat; 55. Downward push electric actuator; 56. Tensioning seat; 57. V-shaped positioning groove; 58. Elastic protrusion; 59. Guide cylinder; 60. Limiting flange; 61. Sliding sleeve; 62. Spring; 63. Pushing assembly; 64. Pushing cylinder; 65. Horizontal push electric actuator; 66. Pushing disk; 67. Clearance groove; 68. Controller.

[0038] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used together with the embodiments of the invention to explain the invention and do not constitute a limitation thereof. Detailed Implementation

[0039] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0040] In the description of this invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0041] like Figures 1-5 As shown, the present invention provides an automated injection device for batch mouse drug testing, comprising a base 1, an experimental box 2, a rotary mouse trapping and fixing mechanism 3, an injection mechanism 4, and an observation box 5. A support frame 6 is mounted on the base 1, the experimental box 2 is positioned above the support frame 6, the observation box 5 is mounted on the base 1, the rotary mouse trapping and fixing mechanism 3 is mounted on the base 1, and its head and tail are connected to the experimental box 2 and the observation box 5, respectively. The injection mechanism 4 is mounted on the base 1 and located on one side of the rotary mouse trapping and fixing mechanism 3. The rotary mouse trapping and securing mechanism 3 includes a fixing frame 7, an attraction channel 8, a trapping rotary frame 9, a one-way mouse securing cage 10, and an output channel 11. The fixing frame 7 is mounted on a base 1, and a fixing mesh 12 is fixedly connected to the side wall of the fixing frame 7. The trapping rotary frame 9 is coaxially rotatably mounted on the side wall of the fixing mesh 12. A Geneva actuator 13 is provided on the side wall of the fixing frame 7 to drive the trapping rotary frame 9 to rotate intermittently. The one-way mouse securing cage 10 rotates through the trapping rotary frame 9 and is arranged in a circular array around the axis of the trapping rotary frame 9. The mouse unidirectional fixation cage 10 has hollow ends. Multiple sets of axial mesh holes 14 are arrayed on the sidewalls of the mouse unidirectional fixation cage 10. One end of the mouse unidirectional fixation cage 10 is tightly fitted to the fixing mesh disk 12, and the other end of the mouse unidirectional fixation cage 10 has a rotatable cage door 15. The attraction channel 8 is connected to the bottom of the sidewall of the experimental chamber 2, and intermittently connects to the mouse unidirectional fixation cage 10. The sidewall of the fixing mesh disk 12 has an output opening 16. One end of the output channel 11 is connected to the output opening 16, and the other end of the output channel 11 is located in the observation box. Above 5, the side wall of the fixed mesh tray 12 is provided with a trap box 17, which contains trapping material. The trapping material traps the mice in the experimental box 2. The mice enter the mouse one-way fixed cage 10 along the attraction channel 8. Then, driven by the Geneva actuator 13, the mice rotate intermittently with the trapping turntable 9 to facilitate tail vein injection. When the mouse one-way fixed cage 10 rotates to the injection mechanism 4, the mice are injected into the tail vein. Then, it continues to rotate to the output opening 16 and is sent into the observation box 5 through the output opening 16 and the output channel 11.

[0042] See Figure 2 and Figure 13The fixed frame 7 has a drive cavity 48 on its side wall. The Geneva drive 13 includes a geared motor 50, a drive wheel 51, and a driven grooved wheel 52. The drive wheel 51 and the driven grooved wheel 52 are rotatably disposed within the drive cavity 48. The geared motor 50 is disposed on the side wall of the drive cavity 48, and the output shaft of the geared motor 50 is coaxially fixed to the drive wheel 51. The driven grooved wheel 52 has a plurality of radial grooves 70 and a plurality of concave arc grooves arranged in a circumferential array on its side wall, with the radial grooves 70 and concave arc grooves spaced apart. A pin 69 and a blocking disc 71 are provided on one side wall of the drive wheel 51, with the pin 69 eccentrically disposed on the drive wheel 51. On the side wall, the pin 69 can extend into the radial groove 70 and drive the driven groove wheel 52 to rotate intermittently with equal amplitude. The blocking disk 71 is coaxially fixed to the side wall of the driving wheel 51. The blocking disk 71 includes a concave arc segment and a convex arc segment. The number of radial grooves 70 is equal to the number of mouse unidirectional fixing cages 10, which is N. The driven groove wheel 52 is coaxially fixed to the trapping turntable frame 9. The reduction motor 50 drives the driving wheel 51 to rotate slowly. When the driving wheel 51 rotates one revolution, the driven groove wheel 52 rotates 360 / N° through the pin 69, realizing intermittent equal amplitude rotation, which facilitates mouse trapping, injection and output.

[0043] See Figures 2-5 The trapping turntable 9 includes a rotating shaft 35, a first turntable 36, and a second turntable 37. The rotating shaft 35 is coaxially rotatably mounted on the side wall of the fixed net tray 12. The first turntable 36 and the second turntable 37 are coaxially fixedly mounted on the rotating shaft 35. The first turntable 36 has a first rotating hole 38 arranged in a circular array around the rotating shaft 35, and the second turntable 37 has a second rotating hole 39 arranged in a circular array around the rotating shaft 35. The first rotating hole 38 and the second rotating hole 39 correspond one-to-one and are coaxially arranged. The mouse one-way fixed cage 10 has a fixed flange 21 at each end. The fixed flange 21 is rotatably mounted in the first rotating hole 38 and the second rotating hole 39. A connecting rod 40 is provided between the fixed flanges 21 at both ends of the mouse one-way fixed cage 10.

[0044] like Figures 5-6 As shown, the fixed flange 21 is provided with a door hole 22, and a door hinge 23 is rotatably inserted through the door hole 22. The cage door 15 is fixedly connected to the door hinge 23. The side wall of the mouse one-way fixed cage 10 is provided with a reset cavity 24. The door hinge 23 rotatably inserts through the reset cavity 24. A coil spring is provided in the reset cavity 24. One end of the coil spring is connected to the door hinge 23, and the other end of the coil spring is connected to the inner wall of the reset cavity 24. When the cage door 15 is offset from the end of the mouse one-way fixed cage 10, the coil spring can easily drive the cage door 15 to reset and close the mouse one-way fixed cage 10, preventing the mouse from escaping.

[0045] See Figure 5 and Figure 7To prevent the mouse from retreating, the one-way mouse cage 10 is provided with a circumferential array of one-way hinges 26 on its side wall. Each one-way hinge 26 is rotatably positioned within an axial mesh 14. A limiting plate 27 is provided within the axial mesh 14, positioned close to the upper end of each one-way hinge 26 on the side away from the cage door 15. The limiting plates 27 are arranged in a circumferential array around the one-way mouse cage 10, corresponding to each one-way hinge 26. A return spring 28 is provided between the one-way hinge 26 and the one-way mouse cage 10, pulling the one-way hinge 26 to a tight position. The mouse's body is positioned such that the circular through-holes formed by multiple one-way hinges 26 allow the mouse to pass through. After the mouse passes through the circular through-holes formed by the one-way hinges 26, the one-way hinges 26 cannot rotate backward due to the restriction of the limiting plate 27, thus preventing the mouse from exiting the one-way mouse fixing cage 10. The bottom wall of the one-way mouse fixing cage 10 is provided with a weight-increasing block 19. The weight-increasing block 19 facilitates the automatic adjustment of the angle of the one-way mouse fixing cage 10 as it rotates with the trapping turntable 9, thereby ensuring that the one-way mouse fixing cage 10 always remains vertical, improving the stability of the device, and preventing the rotation of the trapping turntable 9 from causing discomfort to the mouse.

[0046] See Figure 5 , Figure 6 , Figure 8 and Figure 9 The cage door 15 has an annular protrusion 29 on the side away from the mouse one-way fixation cage 10. The length of the annular protrusion 29 is greater than the length from the end of the attraction channel 8 to the end of the mouse one-way fixation cage 10. So when the mouse one-way fixation cage 10 rotates to the attraction channel 8, the attraction channel 8 pushes the cage door 15 to rotate through the annular protrusion 29, thereby opening the cage door 15 so that the attraction channel 8 and the mouse one-way fixation cage 10 are aligned and connected. The bottom wall of the cage door 15 has an avoidance notch 30. The edge of the avoidance notch 30 extends upward to a human-shaped hole 31. The avoidance notch 30 and the human-shaped hole 31 facilitate the mouse tail to be exposed from the mouse one-way fixation cage 10. The side wall of the fixed net tray 12 has an annular extension plate 32. The end of the annular extension plate 32 has a fan-shaped plate 33. The trapping turntable 9 is rotatably positioned between the fan-shaped plate 33 and the fixed net tray 12. The side of the fan-shaped plate 33 near the trapping turntable 9 has an infrared heating lamp 34. The infrared heating lamp 34 heats the mouse tail, thereby facilitating the dilation of veins.

[0047] like Figures 5-8As shown, to facilitate the fixation of mice of different sizes, the mouse one-way fixation cage 10 has a through-hole 41 in the middle. A limiting component 42 is fixedly connected to the door hinge 23. The limiting component 42 is rotatably disposed within the limiting hole 41. The limiting component 42 includes a limiting sleeve 43, a limiting disk 44, and a limiting tension spring 45. The side wall of the limiting sleeve 43 has a protrusion, which is fixedly connected to the door hinge 23. The limiting sleeve 43 is open on one side. The limiting disk 44 is slidably disposed within the limiting sleeve 43, and a limiting tension spring 45 is disposed between the limiting disk 44 and the limiting sleeve 43. The limiting tension spring 45 causes the limiting disk 44 to tend to move closer to the limiting sleeve 43. The limiting disk 44, the limiting sleeve 43, and the cage door 15 are arranged coaxially. A fan-shaped magnetic block 46 is provided on the side wall of the fixed mesh disk 12 away from the trapping turntable frame 9. The magnetic poles of the fan-shaped magnetic block 46 are the same as those of the side adjacent to the limiting disk 44. Therefore, when the limiting disk 44 rotates to the sector magnetic block 46, the sector magnetic block 46 generates a magnetic repulsion force on the limiting disk 44. The magnetic repulsion force is greater than the elastic force of the limiting tension spring 45. The magnetic repulsion force causes the limiting disk 44 to overcome the elastic force of the limiting tension spring 45, extend out of the limiting sleeve 43, and move along the mouse unidirectional fixation cage 10, thus adaptively fixing and limiting the mouse. The sector magnetic block 46 is coaxially arranged with the trapping turntable 9, and the sector magnetic block 46 is located away from the trapping box 17 and On one side of the output opening 16, when the limiting disk 44 rotates to the trap box 17 or the output opening 16, the limiting disk 44 retracts into the limiting sleeve 43 under the elastic force of the limiting tension spring 45; ventilation holes 47 are distributed on the limiting disk 44 and the limiting sleeve 43, and a flexible sponge layer is wrapped on the side wall of the limiting disk 44 away from the limiting sleeve 43 to achieve adaptive non-destructive fixation and limitation of the mouse. The flexible sponge layer is not shown in the figure.

[0048] See Figure 2 and Figure 9 The trap box 17 is aligned with the axis of the attraction channel 8. The length from the axis of the attraction channel 8 to the axis of the trap turntable 9 is equal to the length from the axis of the mouse one-way fixed cage 10 to the axis of the trap turntable 9. Thus, when the attraction channel 8 is connected to the mouse one-way fixed cage 10, the attraction channel 8, the mouse one-way fixed cage 10 and the trap box 17 are arranged on the same axis. Both ends of the trap box 17 are hollow. One end of the trap box 17 is located on the side wall of the fixed net tray 12. The end of the trap box 17 away from the fixed net tray 12 is threaded with an end cap 20. The end cap 20 facilitates the replacement of the trapping material.

[0049] like Figure 11 and Figure 12As shown, the injection mechanism 4 includes an upward-pushing electric plunger 53, a V-shaped fixing seat 54, a downward-moving electric plunger 55, and a tensioning seat 56. The upward-pushing electric plunger 53 is located on the upper wall of the base 1. The V-shaped fixing seat 54 is located at the upper end of the upward-pushing electric plunger 53 and is located on one side of the trapping turntable 9. The length of the V-shaped fixing seat 54 to the end of the mouse one-way fixing cage 10 is slightly less than the length of the annular protrusion 29. The upper wall of the V-shaped fixing seat 54 is provided with a V-shaped positioning groove 57. The V-shaped positioning groove 57 and the human-shaped hole 31 cooperate to facilitate the positioning of the mouse tail. The downward-moving electric plunger 55 is located on the base on the side of the upward-pushing electric plunger 53 away from the trapping turntable 9. 1. The tensioning seat 56 is mounted on the downward-moving electric push rod 55. Semi-cylindrical elastic protrusions 58 are arranged in an array on the side wall of the tensioning seat 56. The elastic protrusions 58 are located between the tensioning seat 56 and the V-shaped fixing seat 54. In the initial state, the height of the tensioning seat 56 is greater than the height of the V-shaped fixing seat 54. When injecting a mouse, the upward-moving electric push rod 53 pushes the V-shaped fixing seat 54 upward, so that the V-shaped fixing seat 54 is close to the upper end of the human-shaped hole 31. The downward-moving electric push rod 55 drives the tensioning seat 56 downward. The elastic protrusions 58 pull the mouse tail downward through friction, thereby making the mouse tail tensioned and fixed at the bottom of the middle part of the V-shaped positioning groove 57.

[0050] See Figure 10 The support frame 6 has a pushing component 63 on its side wall. The pushing component 63 is attached to the end of the mouse one-way fixation cage 10. The pushing component 63 includes a pushing cylinder 64, a horizontal pushing electric rod 65, and a pushing disk 66. The pushing cylinder 64 is located on the side wall of the support frame 6, and the side of the pushing cylinder 64 closest to the mouse one-way fixation cage 10 is hollow. The horizontal pushing electric rod 65 is located inside the pushing cylinder 64, and the pushing disk 66 is located on the side of the horizontal pushing electric rod 65 closest to the mouse one-way fixation cage 10. The pushing disk 66 has circumferentially arranged avoidance grooves 67 aligned with the one-way hinge rod 26, which avoid the one-way hinge rod 26. The pushing cylinder 64 is located diagonally below the attraction channel 8, and the end of the pushing cylinder 64 is close to the mouse one-way... The length of the end of the fixed cage 10 is less than the length of the annular protrusion 29. The length from the axis of the push tube 64 to the axis of the trap turntable 9 is equal to the length from the axis of the mouse one-way fixed cage 10 to the axis of the trap turntable 9. When the mouse one-way fixed cage 10 rotates and approaches the push tube, the push tube 64 pushes the cage door 15 to rotate and avoid it through the annular protrusion 29, so that the push tube 64 and the mouse one-way fixed cage 10 can be aligned and connected. The tensioning seat 56 is provided with a guide tube 59 that runs through the front and back. The end of the guide tube 59 is provided with a limiting flange 60. A sliding sleeve 61 is sleeved on the outside of the guide tube 59. A spring 62 is provided between the sliding sleeve 61 and the limiting flange 60. The guide tube 59 facilitates the guidance of the syringe and facilitates accurate injection.

[0051] The diameter of the attraction channel 8 and the diameter of the mouse one-way fixation cage 10 are greater than 2.5 cm and less than 4.5 cm, so that only one mouse can pass through the attraction channel 8 and the mouse one-way fixation cage 10 at the same time. The base 1 is equipped with a controller 68, which is electrically connected to the reduction motor 50, the horizontal push electric push rod 65, the upward push electric push rod 53, the downward movement electric push rod 55, and the infrared heating lamp 34.

[0052] In practical use, all mice to be injected are placed in the experimental chamber 2. Then, the end cap 20 is screwed on to open the trap box 17. The trapping material is placed into the trap box 17, and the end cap 20 is tightened again. Then, the Geneva actuator 13 is started, and the syringe containing the drug solution is placed into the guide tube 59. The reduction motor 50 drives the drive wheel 51 to rotate slowly. One rotation of the drive wheel 51 is one cycle. The drive wheel 51 drives the pin shaft 69 to rotate. One cycle includes the stage of the pin shaft 69 rotating into the radial groove 70 and the stage of the pin shaft 69 rotating out of the radial groove 70. When the pin shaft 69 rotates into the radial groove 70, the pin shaft 69 pushes the driven groove wheel 52 to rotate 360°. The driven groove wheel 52 drives the trap turntable 9 to rotate through the rotating shaft 35. The trap turntable 9 drives the mouse unidirectional fixation cage. 10 rotates from its current position to the position of the downward mouse unidirectional fixation cage 10, realizing intermittent equal-amplitude adjustment of the mouse unidirectional fixation cage 10. When the pin 69 rotates out of the radial groove 70, the convex arc segment of the blocking plate 71 is engaged in the concave arc groove, limiting the driven groove wheel 52. The driven groove wheel 52 remains stationary, realizing intermittent equal-amplitude rotation. At this time, the controller 68 controls the upward push electric push rod 53 to extend, and then controls the downward push electric push rod 55 to shorten. At the same time, the controller 68 controls the horizontal push electric push rod 65 to first extend and then shorten to reset. The upward push electric push rod 53 pushes the V-shaped fixing seat 54 to move upward, so that the upper wall of the V-shaped fixing seat 54 is close to the upper end of the human-shaped hole 31 of the cage door 15 at the bottom of the trapping turntable frame 9. The downward push electric push rod 55 drives the tensioning seat 56 to move downward to the tensioning seat 5. The upper wall of the 6th column is slightly lower than the upper wall of the V-shaped fixing seat 54 after it has been moved upward. At this time, the attraction channel 8 is aligned and connected with the mouse one-way fixing cage 10 in front of the attraction channel 8. During the rotation and repositioning process, the cage door 15 of the mouse one-way fixing cage 10 in front of the attraction channel 8 is pushed away from the end of the mouse one-way fixing cage 10 by the attraction channel 8. Under the attraction of the trapping material, the mice enter the attraction channel 8 one by one and pass through the circular through holes formed by multiple one-way hinges 26 into the mouse one-way fixing cage 10. The return spring 28 pulls the one-way hinges 26 to fit tightly against the mouse's body, so that the circular through holes formed by multiple one-way hinges 26 can just allow the mouse to pass through. After the mouse passes through the circular through holes formed by the one-way hinges 26, the one-way hinges 26 cannot rotate backward due to the restriction of the limiting plate 27. The mouse cannot exit the one-way mouse cage 10, and due to the restriction of the mouse in front, the one-way hinge 26 cannot rotate forward, and the mouse behind cannot re-enter the same one-way mouse cage 10. The other end of the one-way mouse cage 10 is blocked by the fixed mesh 12. At this time, the cage door 15 drives the limiting sleeve 43 and the limiting disk 44 to rotate out of the one-way mouse cage 10 through the rotating shaft 35. Since there is no fan-shaped magnetic block 46 on the fixed mesh 12 in front of the attraction channel 8, the limiting disk 44 retracts into the limiting sleeve 43 under the elastic force of the limiting tension spring 45. When the pin 69 rotates into the radial groove 70 again in the next cycle, the driven groove wheel 52 drives the trapping turntable 9 to rotate again, and the controller 68 controls the upper push rod 53 and the lower push rod 55 to reset.At this moment, the mouse one-way fixation cage 10, located in front of the attraction channel 8, rotates upward by 360°, making a constant amplitude adjustment. The trapping turntable 9 drives the mouse one-way fixation cage 10, which is holding the mouse, to rotate upward away from the attraction channel 8. The door hinge 23 gradually returns to its original position under the action of the coil spring. The door hinge 23 drives the cage door 15 to gradually block the mouse one-way fixation cage 10, and drives the limiting sleeve 43 to rotate back into the mouse one-way fixation cage 10 through the limiting rotating hole 41. The mouse's tail protrudes from the avoidance notch 30. Then, after the trapping turntable 9 rotates 360° again, the mouse one-way fixation cage 10, which holds the mouse, rotates to the space between the fan-shaped disk 33 and the fixed mesh disk 12. A fan-shaped magnetic block 46 is located in front of the mouse one-way fixation cage 10. The fan-shaped magnetic block 46 generates a magnetic repulsion force on the limiting disk 44. This magnetic repulsion force is greater than the elastic force of the limiting spring 45. The magnetic repulsion force causes the limiting disk 44 to overcome the elastic force of the limiting spring 45, extend out of the limiting sleeve 43, and move along the mouse one-way fixation cage 10, thus adapting the mouse to its surroundings. A fixed limit is set in place, and an infrared lamp 34 heats the mouse tail to facilitate vein dilation. When the mouse-containing one-way cage 10 rotates to the bottom of the trapping turntable 9 after several cycles, tail vein injection can be performed. At this time, the front part of the mouse tail is supported by an upward-moving V-shaped fixing seat 54 and fixed between the V-shaped fixing seat 54 and the upper end of the human-shaped hole 31. The rear end of the mouse tail is pressed down by a tensioning seat 56 and clamped between the tensioning seat 56 and the V-shaped fixing seat 54. As the tensioning seat 56 moves downward, the mouse tail is tensioned. After the upward-pushing electric actuator 53 and the downward-moving electric actuator 55 are in position, the operator only needs to push the syringe forward along the guide tube 59. The syringe compresses the sliding sleeve 61, allowing the needle to insert into the mouse tail vein. Then, pressing the syringe injects the drug. This achieves automated batch capture and fixation of experimental mice, greatly reducing the labor intensity and operational difficulty of tail vein injection, and realizing automated injection for batch mouse drug experiments.

[0053] After the injection is completed, the syringe is removed. In the next cycle, the trapping turntable 9 will drive the injected mouse to rotate to the push tube 64. The push tube 64 pushes the cage door 15 to rotate and avoid it through the annular protrusion 29, so that the push tube 64 can be aligned and connected with the mouse one-way fixed cage 10. When the pin 69 rotates out of the radial groove 70, the controller 68 controls the transverse electric push rod to extend first, and send the injected mouse into the observation box 5 along the mouse one-way fixed cage 10 and the output channel 11.

[0054] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0055] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

[0056] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention; the actual structure is not limited thereto. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the invention, such designs should fall within the protection scope of the present invention.

Claims

1. An automated injection device for batch mouse drug testing, characterized in that: The device includes a base, an experimental box, a turntable mouse trapping and securing mechanism, an injection mechanism, and an observation box. A support frame is mounted on the base, the experimental box is positioned above the support frame, and the observation box is located on the base. The turntable mouse trapping and securing mechanism is mounted on the base, with its first and last ends connected to the experimental box and the observation box, respectively. The injection mechanism is located on the base and on one side of the turntable mouse trapping and securing mechanism. The turntable mouse trapping and securing mechanism includes a securing frame, a lure channel, a trapping turntable frame, a one-way mouse securing cage, and an output channel. The securing frame is mounted on the base, and a securing mesh is fixedly connected to its side wall. The trapping turntable frame is coaxially rotatable on the side wall of the securing mesh. A driving lure is provided on the side wall of the securing frame. The trapping turntable is driven by a Geneva actuator that rotates intermittently. A unidirectional mouse cage rotates through the trapping turntable. The unidirectional mouse cages are arranged in a circular array around the axis of the turntable. Both ends of each unidirectional mouse cage are hollow. Multiple sets of axial mesh holes are arranged in an array on the sidewalls of each unidirectional mouse cage. One end of each unidirectional mouse cage is tightly fitted to a fixed mesh tray, while the other end has a rotatable cage door. An attraction channel is located at the bottom of the sidewall of the experimental chamber and intermittently connects to the unidirectional mouse cage. An output opening is located on the sidewall of the fixed mesh tray. One end of the output channel is connected to the output opening, and the other end is located above the observation box. A trapping box is located on the sidewall of the fixed mesh tray, containing trapping material. The mouse unidirectional cage has fixed flanges at both ends, and the mouse unidirectional cage is rotatably connected to the trapping turntable via the fixed flanges. Each fixed flange has a door hole through which a door hinge rotatably passes. The cage door is fixedly mounted on the door hinge. A reset cavity is provided on the side wall of the mouse unidirectional cage, through which the door hinge rotatably passes. A coil spring is provided inside the reset cavity; one end of the coil spring is connected to the door hinge, and the other end is connected to the inner wall of the reset cavity. A connecting rod is provided between the fixed flanges at both ends of the mouse unidirectional cage. A limiting rotating hole is provided in the middle of the mouse unidirectional cage, and a limiting component is fixedly mounted on the door hinge. The limiting component rotatably moves within the limiting hole. Inside the positioning hole, the limiting assembly includes a limiting sleeve, a limiting disk, and a limiting tension spring. The limiting sleeve has a protrusion on its side wall, which is fixedly connected to the door hinge. The limiting sleeve is open on one side. The limiting disk is slidably disposed inside the limiting sleeve. The limiting tension spring is disposed between the limiting disk and the limiting sleeve, causing the limiting disk to tend to move closer to the limiting sleeve. The limiting disk, the limiting sleeve, and the cage door are arranged coaxially. The side wall of the fixed mesh tray away from the trapping turntable is provided with a fan-shaped magnetic block. The magnetic poles of the fan-shaped magnetic block are the same as those of the side adjacent to the limiting disk. The fan-shaped magnetic block is arranged coaxially with the trapping turntable and is located on the side away from the trapping box and the output opening.

2. The automated injection device for batch mouse drug testing according to claim 1, characterized in that: The bottom wall of the mouse one-way fixed cage is provided with a weight-increasing block. The cage door is provided with an annular protrusion on the side away from the mouse one-way fixed cage. The length of the annular protrusion is greater than the length from the end of the attraction channel to the end of the mouse one-way fixed cage. The bottom wall of the cage door is provided with an avoidance notch. The edge of the avoidance notch extends upward to a human-shaped hole. The side wall of the fixed net tray is provided with an annular extension plate. The end of the annular extension plate is provided with a fan-shaped plate. The trapping turntable is rotatably positioned between the fan-shaped plate and the fixed net tray. An infrared lamp is provided on the side of the fan-shaped plate near the trapping turntable.

3. The automated injection device for batch mouse drug testing according to claim 2, characterized in that: The injection mechanism includes an upward-pushing electric plunger, a V-shaped fixing seat, a downward-moving electric plunger, and a tensioning seat. The upward-pushing electric plunger is located on the upper wall of the base. The V-shaped fixing seat is located at the upper end of the upward-pushing electric plunger and on one side of the trapping turntable. The length from the V-shaped fixing seat to the end of the mouse unidirectional fixing cage is slightly less than the length of the annular protrusion. The upper wall of the V-shaped fixing seat has a V-shaped positioning groove. The downward-moving electric plunger is located on the base on the side of the upward-pushing electric plunger away from the trapping turntable. The tensioning seat is located on the downward-moving electric plunger. Semi-cylindrical elastic protrusions are arranged in an array on the side wall of the tensioning seat. The elastic protrusions are located between the tensioning seat and the V-shaped fixing seat. A cold light is installed in the V-shaped positioning groove. A guide cylinder that runs through the front and back is provided on the tensioning seat. A limiting flange is provided at the end of the guide cylinder. A sliding sleeve is sleeved on the outside of the guide cylinder. A spring is provided between the sliding sleeve and the limiting flange.

4. The automated injection device for batch mouse drug testing according to claim 3, characterized in that: The support frame has a pushing component on its side wall, which fits against the end of the mouse unidirectional fixation cage. The pushing component includes a pushing cylinder, a horizontal pushing electric rod, and a pushing disk. The pushing cylinder is located on the side wall of the support frame, and the side of the pushing cylinder closest to the mouse unidirectional fixation cage is hollow. The pushing cylinder is coaxial with the output opening. The horizontal pushing electric rod is located inside the pushing cylinder, and the pushing disk is located on the side of the horizontal pushing electric rod closest to the mouse unidirectional fixation cage. The pushing cylinder is located diagonally below the attraction channel. The length from the end of the pushing cylinder to the end of the mouse unidirectional fixation cage is less than the length of the annular protrusion. The length from the axis of the pushing cylinder to the axis of the trapping turntable is equal to the length from the axis of the mouse unidirectional fixation cage to the axis of the trapping turntable.

5. The automated injection device for batch mouse drug testing according to claim 4, characterized in that: The mouse unidirectional fixation cage has multiple unidirectional hinges arranged in a circumferential array on its side wall. The unidirectional hinges are rotatably positioned within axial mesh holes. A limiting plate is provided within the axial mesh holes. The limiting plate is located close to the upper end of the unidirectional hinge and is positioned on the side of the unidirectional hinge away from the cage door. The limiting plates are arranged in a circumferential array around the mouse unidirectional fixation cage, and the limiting plates are correspondingly positioned with the unidirectional hinges. A reset tension spring is provided between the unidirectional hinge and the mouse unidirectional fixation cage. The push plate has circumferentially arrayed clearance grooves aligned with the unidirectional hinges.

6. The automated injection device for batch mouse drug testing according to claim 5, characterized in that: The side wall of the fixing frame is provided with a driving cavity. The Geneva actuator includes a geared motor, a driving wheel, and a driven grooved wheel. The driving wheel and the driven grooved wheel are rotatably disposed in the driving cavity. The geared motor is disposed on the side wall of the driving cavity. The output shaft of the geared motor is coaxially fixed to the driving wheel. The driven grooved wheel has multiple radial grooves and multiple concave arc grooves distributed in a circumferential array on its side wall. The radial grooves and concave arc grooves are spaced apart. A pin and a blocking disc are provided on one side wall of the driving wheel. The pin is eccentrically disposed on the side wall of the driving wheel. The pin rotates and extends into the radial groove, driving the driven grooved wheel to rotate intermittently with a constant amplitude. The blocking disc is coaxially fixed to the side wall of the driving wheel. The blocking disc includes a concave arc segment and a convex arc segment. The number of radial grooves is equal to the number of mouse unidirectional fixing cages.

7. The automated injection device for batch mouse drug testing according to claim 6, characterized in that: Ventilation holes are provided on the limiting disk and the limiting sleeve. A flexible sponge layer is wrapped on the side wall of the limiting disk away from the limiting sleeve. The diameter of the induction channel and the diameter of the mouse unidirectional fixation cage are greater than 2.5 cm and less than 4.5 cm.

8. The automated injection device for batch mouse drug testing according to claim 7, characterized in that: The trap box is hollow at both ends. One end of the trap box is located on the side wall of the fixed net tray, and the end of the trap box away from the fixed net tray is threaded with an end cap. The trap box is aligned with the axis of the attraction channel. The length from the axis of the attraction channel to the axis of the trap turntable is equal to the length from the axis of the mouse unidirectional fixed cage to the axis of the trap turntable.

9. The automated injection device for batch mouse drug testing according to claim 8, characterized in that: The base is equipped with a controller, which is electrically connected to the geared motor, the horizontal push electric actuator, the upward push electric actuator, the downward movement electric actuator, and the infrared heating lamp.

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