Degradable bone repair metal material and preparation method thereof

Abstract

The application provides a degradable bone repair metal material and a preparation method thereof, which comprises a zinc base and magnesium-based particles; the zinc base wraps the magnesium-based particles, and the zinc base is formed after zinc-based metal is melted and filled into the gaps between the magnesium-based particles. The magnesium-based particles degrade before the zinc base in the process of use, and the zinc base forms a zinc-based bone repair scaffold with a connected porous structure after the magnesium-based particles degrade. In the preparation, the selected magnesium-based particles are subjected to fluorination treatment, and then are placed in a casting mold for heat preservation; the selected zinc-based metal is melted and poured into the casting mold, and then is cooled, cleaned and dried to obtain the degradable bone repair metal material. The preparation process of the application is simple, has no loss of filling templates, no residues of pore-forming agents and no safety risks, and the bone repair scaffold formed has uniform pores and controllable size.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of biomedical materials, and relates to a degradable bone repair metal material and a preparation method thereof. BACKGROUND

[0002] Due to bone tumors, osteoporosis, trauma and other reasons, patients may have bone defect conditions, and it is often necessary to fill the defect site and perform bone repair. At present, bone repair materials for filling mainly include biological ceramic materials, polymer materials, metal materials and the like. Among them, porous magnesium and porous zinc materials have become potential porous bone tissue repair materials due to their good mechanical properties, porous bionic structure and in-vivo degradable characteristics.

[0003] In the existing disclosed technology, the preparation methods of the porous magnesium / zinc material mainly include infiltration casting, melt foaming and additive manufacturing. The porous magnesium / zinc material prepared by the infiltration casting method is mostly filled with sodium chloride particles as a filling template, and after casting, a large amount of solution is needed to wash away the sodium chloride particles to obtain a porous structure. This method is simple in process, and the pores are connected, but the pore shape is random, and during the washing process, local corrosion of the porous magnesium / zinc material may occur, or the core sodium chloride may not be completely washed, affecting the performance of the final porous magnesium / zinc material. The porous magnesium / zinc material prepared by the melt foaming method is obtained by adding a foaming agent to the molten metal liquid, and after a certain foaming time, a porous structure is obtained. This method is simple in process and does not need to be washed, but the porous structure is mainly closed, which is not conducive to cell growth and nutrient transport after implantation. The porous magnesium / zinc material prepared by additive manufacturing mainly uses laser diffraction to directly obtain a porous material. The porosity, pore shape and pore size of the porous material prepared by this method can be designed and controlled, but the process cost is high, and metal powder needs to be used in the preparation process, which is dangerous.

[0004] Therefore, a new porous bone repair material and a preparation method thereof are needed to solve the problems existing in the prior art and meet the repair needs of bone defect sites. SUMMARY

[0005] In view of the above technical problems, the application provides a degradable bone repair metal material, which can gradually form a porous structure after being implanted into the human body, and the pores are connected and uniform in shape.

[0006] The application also provides a preparation method of the degradable bone repair metal material, which is simple in preparation process, has no filling template loss, no pore former residue and is safe and controllable.

[0007] The degradable bone repair metal material comprises a magnesium-based particle and a zinc-based body, and can form a zinc-based bone repair scaffold with a connected porous structure after being implanted into a human body. In preparation, the selected magnesium-based particle is subjected to fluorination treatment and then placed in a casting mold for heat preservation; the selected zinc-based metal is melted and poured into the casting mold, and then cooled, cleaned and dried to obtain the degradable bone repair metal material. The preparation process of the present application is simple, has no loss of filling templates, no residue of pore-forming agents, and no safety risks, and the bone repair scaffold formed has uniform pores and controllable size.

[0008] The present application achieves the above technical purpose through the following technical means.

[0009] A degradable bone repair metal material comprises a zinc-based body and a magnesium-based particle.

[0010] The magnesium-based particles are in contact with each other, and the zinc-based body wraps the magnesium-based particles. The zinc-based body is formed after the zinc-based metal fills the gaps between the magnesium-based particles.

[0011] In the above scheme, the magnesium-based particles degrade before the zinc-based body in the process of use, and the zinc-based body forms a zinc-based bone repair scaffold with a connected porous structure after the magnesium-based particles degrade.

[0012] In the above scheme, the magnesium-based particles are spherical in shape and have a diameter of 200-900 microns, close to the pore diameter of human bone.

[0013] In the above scheme, the magnesium-based particles have a fluorinated layer on the surface.

[0014] In the above scheme, the magnesium-based particles are composed of one of pure magnesium, magnesium-zinc alloy and magnesium-calcium alloy.

[0015] In the above scheme, the zinc-based body is composed of one of pure zinc, zinc-lithium alloy, zinc-manganese alloy, zinc-magnesium alloy, zinc-calcium alloy and zinc-copper alloy.

[0016] A preparation method of the degradable bone repair metal material comprises the following steps:

[0017] Step S1: selecting a magnesium-based particle with a diameter of 200-900 microns, placing it in a hydrofluoric acid solution, soaking at room temperature, and then taking it out for alcohol cleaning and drying to obtain a fluorinated magnesium-based particle;

[0018] Step S2: placing the fluorinated magnesium-based particle obtained in step S1 in a casting mold, shaking and compacting to make the magnesium-based particles tightly contact with each other, and obtaining a casting mold containing magnesium-based particles;

[0019] Step S3: placing the casting mold containing magnesium-based particles obtained in step S2 in an oven at 350-400℃ for heat preservation to improve the flowability of the zinc melt during casting;

[0020] Step S4, select the zinc-based metal of the zinc base, heat and melt under nitrogen protection to form a zinc-based melt;

[0021] Step S5, take out the casting mold of step S3 from the oven, pour the zinc-based melt in step S4 into the casting mold, and the casting temperature is 430-500 DEG C;

[0022] Step S6, after the casting mold is cooled, the upper and lower ends are cut off, washed and dried to obtain a degradable bone repair metal material formed by magnesium-based particles and a zinc base.

[0023] In the above scheme, the magnesium-based particles in step S1 are immersed in a hydrofluoric acid solution at room temperature for 24 hours to achieve good fluorination effect.

[0024] In the above scheme, the casting mold in step S2 has a through hole at the bottom.

[0025] In the above scheme, the casting mold containing magnesium-based particles in step S3 is heated for not less than 1 hour to make the mold heat through.

[0026] In the above scheme, in step S5, when the zinc-based melt is cast, a negative pressure environment is provided in the cavity of the casting mold through the through hole at the bottom of the casting mold.

[0027] The degradable bone repair metal material provided by the application has the advantages that:

[0028] Compared with the prior art, the application has the advantages that:

[0029] 1. The degradable bone repair metal material of the application is formed by two metals with significantly different degradation rates, i.e. magnesium-based particles and a zinc base. After being implanted into the human body, the magnesium-based particles are preferentially and rapidly degraded, and a zinc-based bone repair scaffold with a connected porous structure is formed, thereby eliminating the cleaning process after filling with sodium chloride particles and avoiding the risk of local corrosion or incomplete cleaning during the cleaning process;

[0030] 2. During the initial implantation of the degradable bone repair metal material into the human body, the magnesium-based particles are preferentially and rapidly degraded, the alkaline microenvironment formed can inhibit bacterial growth and slow down the occurrence of inflammatory reactions, and the released magnesium ions are helpful for promoting bone cell growth and beneficial to bone tissue repair;

[0031] 3The zinc-based bone repair scaffold formed by the degradation of the degradable bone repair metal material implanted into the human body has good comprehensive mechanical properties and a slow degradation rate, can match the bone tissue repair speed and gradually degrade, and the uniform spherical pore structure can be used as a channel for cell growth and nutrient transport;

[0032] 4In the preparation method, the hydrofluoric acid soaking step can remove the original oxide on the surface of the magnesium-based particles and form fluorinated magnesium-based particles, and the fluorinated layer can prevent the oxidation of the magnesium-based particles during the heat preservation process of the casting mold, and the fluorinated layer increases the surface roughness and improves the bonding tightness with the zinc matrix;

[0033] 5The preparation process is simple, has no filling template loss, no pore former residue, and no safety risk, the formed bone repair scaffold has uniform pores and controllable size. BRIEF DESCRIPTION OF DRAWINGS

[0034] Figure 1 is a cross-sectional structure schematic diagram of the degradable bone repair metal material of the embodiment of the present application.

[0035] Figure 2 is a cross-sectional structure schematic diagram of the zinc-based bone repair scaffold with a connected porous structure formed by the complete degradation of the magnesium-based particles after the degradable bone repair metal material of the embodiment of the present application is implanted into the human body.

[0036] Figure 3 is a schematic diagram of a casting mold loaded with the fluorinated magnesium-based particles of the embodiment of the present application.

[0037] The meanings of the labels in the drawings are explained as follows:

[0038] 1.Zinc matrix; 2.Magnesium-based particles; 3.Pores formed after the degradation of the magnesium-based particles; 4.Casting mold; 5.High-temperature-resistant net; 6.Pore. DETAILED DESCRIPTION

[0039] The embodiments of the present application are described in detail below, and examples of the embodiments are shown in the drawings, wherein the same or similar reference signs represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are intended to explain the present application, and cannot be understood as a limitation of the present application.

[0040] In the description of the present application, it is to be understood by the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "front", "back", "left", "right", "up", "down", "axial", "radial", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0041] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting", "fixing" and the like should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through intermediate medium, or it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0042] The reagents, materials and the like used in the following examples, if not specifically stated, can be obtained from commercial channels.

[0043] In combination Figure 1 As shown in the figure, a degradable bone repair metal material includes a zinc base 1 and a magnesium-based particle 2; the magnesium-based particles 2 are in contact with each other, the zinc base 1 is formed after the zinc-based metal is melted and filled into the gap between the magnesium-based particles 2, and the zinc base 1 wraps the magnesium-based particles 2. The magnesium-based particles 2 degrade before the zinc base 1 during the process of implanting into the human body for use, and the zinc base forms a zinc-based bone repair scaffold with a connected porous structure after the magnesium-based particles degrade. The preparation process is simple, there is no loss of filling template, and there is no residual pore forming agent. The cleaning process after filling sodium chloride particles is omitted, and the risk of local corrosion or incomplete cleaning during the cleaning process is avoided. The pores 3 formed after the magnesium-based particles 2 degrade are shown in the figure. Figure 2 As shown in the figure.

[0044] Preferably, the shape of the magnesium-based particles 2 is spherical, and the diameter is 200-900 microns.

[0045] The magnesium-based particles 2 have a fluorinated layer on the surface, which can prevent the oxidation of the magnesium-based particles during the heat preservation process of the casting mold 4, and at the same time, the fluorinated layer increases the surface roughness and improves the bonding tightness with the zinc base.

[0046] The composition of the magnesium-based particles 2 is one of pure magnesium, magnesium-zinc alloy, and magnesium-calcium alloy.

[0047] The component of the zinc base body 1 is one of pure zinc, zinc-lithium alloy, zinc-manganese alloy, zinc-magnesium alloy, zinc-calcium alloy, and zinc-copper alloy.

[0048] A preparation method of the degradable bone repair metal material comprises the following steps:

[0049] In step S1, magnesium-based particles 2 with a diameter of 200-900 microns are selected and placed in a hydrofluoric acid solution for room temperature immersion. After being taken out, the magnesium-based particles 2 are cleaned with alcohol and dried to obtain fluorinated magnesium-based particles.

[0050] In step S2, the fluorinated magnesium-based particles 2 obtained in step S1 are placed in a casting mold 4, shaken and compacted to make the magnesium-based particles 2 tightly contact with each other, and the casting mold 4 containing the magnesium-based particles 2 is obtained.

[0051] In step S3, the casting mold 4 containing the magnesium-based particles 2 obtained in step S2 is placed in an oven at 350-400°C for heat preservation.

[0052] In step S4, a zinc-based metal of the zinc base body 1 is selected, and the zinc-based metal is heated and melted to form a zinc-based melt under nitrogen protection.

[0053] In step S5, the casting mold 4 in step S3 is taken out of the oven, and the zinc-based melt in step S4 is poured into the casting mold 4, and the pouring temperature is 430-500°C.

[0054] In step S6, after the casting mold 4 is cooled, the upper and lower ends of the casting mold 4 are cut off, and preferably, 2 cm of the upper and lower ends are cut off, and the casting mold 4 is cleaned and dried to obtain a degradable bone repair metal material formed by the magnesium-based particles 2 and the zinc base body 1.

[0055] Preferably, in step S1, the magnesium-based particles 2 are placed in the hydrofluoric acid solution for room temperature immersion for 24 hours.

[0056] The casting mold 4 in step S2 has a through hole 6 at the bottom.

[0057] Preferably, in step S3, the casting mold 4 containing the magnesium-based particles 2 is heat preserved for not less than 1 hour.

[0058] In the above scheme, in step S5, when the zinc-based melt is poured, a negative pressure environment is provided in the cavity of the casting mold 4 through the through hole 6 at the bottom of the casting mold 4. Figure 3 As shown in the figure, a negative pressure environment is provided in the cavity of the casting mold 4.

[0059] Example 1

[0060] A degradable bone repair metal material is formed by a zinc base 1 and magnesium base particles 2, the magnesium base particles 2 are composed of magnesium-calcium alloy, the shape is spherical, the diameter includes three kinds of 300, 600 and 900 microns, the magnesium base particles 2 are in contact with each other, the zinc base 1 is composed of zinc-lithium alloy, fills the gap between the magnesium base particles 2, and wraps the magnesium base particles 2.

[0061] The embodiment relates to a preparation method of the degradable bone repair metal material, and comprises the following steps:

[0062] In step S(1), magnesium-calcium alloy particles with diameters of 300, 600 and 900 microns are selected, and are soaked in a hydrofluoric acid solution at room temperature for 24 hours, and then are cleaned with alcohol and dried to obtain fluorinated magnesium-calcium alloy particles;

[0063] In step S(2), the magnesium-calcium alloy particles obtained in step S(1) are placed in a casting mold 4, are shaken and compacted to make the magnesium-calcium alloy particles closely contact with each other, and the casting mold 4 filled with the magnesium-calcium alloy particles is obtained;

[0064] In step S(3), the casting mold 4 filled with the magnesium-calcium alloy particles obtained in step S(2) is placed in an oven at 400 DEG C for 1 hour;

[0065] In step S(4), zinc-lithium alloy is selected, and is heated and melted to form a zinc-lithium alloy melt under nitrogen protection;

[0066] In step S(5), the casting mold 4 in step S(3) is taken out from the oven, and the zinc-lithium alloy melt in step S(4) is poured into the casting mold 4, and the pouring temperature is 430 DEG C;

[0067] In step S(6), after the casting mold 4 is cooled, the upper and lower ends are each cut off by 2 cm, and the degradable bone repair metal material formed by the magnesium-calcium alloy particles and the zinc-lithium alloy shell is obtained after cleaning and drying.

[0068] The bottom of the casting mold 4 has a through hole 6, and is provided with a high-temperature-resistant mesh 5 with a pore size less than 300 microns; and a negative pressure environment is provided in the cavity of the casting mold 4 through the through hole 6 in the bottom of the casting mold 4 during pouring.

[0069] The magnesium base particles 2 are degraded before the zinc base 1 in the process of being implanted into the human body, the zinc base forms a zinc-based bone repair scaffold with a connected porous structure after the magnesium base particles are degraded, the preparation process is simple, there is no loss of filling templates and no residue of pore-forming agents, the cleaning process after filling of sodium chloride and other particles is omitted, and the risk of local corrosion or incomplete cleaning in the cleaning process is avoided.

[0070] Embodiment 2

[0071] The embodiment relates to a degradable bone repair metal material formed by magnesium-based particles 2 and a zinc-based body 1, the magnesium-based particles 2 are composed of a magnesium-zinc alloy, have a diameter of 500 microns, are spherical in shape, and are in close contact with each other, and the zinc-based body 1 is composed of a zinc-magnesium alloy and fills the gaps between the magnesium-based particles 2 to wrap the magnesium-based particles 2.

[0072] The embodiment relates to a preparation method of the degradable bone repair metal material.

[0073] In step S(1), magnesium-zinc alloy particles with a diameter of 500 microns are selected, and then the magnesium-zinc alloy particles are soaked in a hydrofluoric acid solution at room temperature for 24 hours, and after being taken out, the magnesium-zinc alloy particles are cleaned with alcohol and dried to obtain fluorinated magnesium-zinc alloy particles.

[0074] In step S(2), the magnesium-zinc alloy particles obtained in step S(1) are placed in a casting mold 4, and the magnesium-zinc alloy particles are vibrated and compacted to make the magnesium-zinc alloy particles in close contact with each other, so that the casting mold 4 containing the magnesium-zinc alloy particles is obtained.

[0075] In step S(3), the casting mold 4 containing the magnesium-zinc alloy particles obtained in step S(2) is placed in an oven at 350 DEG C for 1 hour.

[0076] In step S(4), a zinc-magnesium alloy is selected, and then the zinc-magnesium alloy is heated and melted to form a zinc-magnesium alloy melt under the protection of nitrogen.

[0077] In step S(5), the casting mold 4 in step S(3) is taken out from the oven, and the zinc-magnesium alloy melt in step S(4) is poured into the casting mold 4, and the pouring temperature is 450 DEG C.

[0078] In step S(6), after the casting mold 4 is cooled, the upper end and the lower end of the casting mold 4 are each cut off by 2 centimeters, and then the casting mold 4 is cleaned and dried to obtain a degradable bone repair metal material formed by magnesium-zinc alloy particles and a zinc-magnesium alloy shell.

[0079] The bottom of the casting mold 4 is provided with a through hole 6, and the through hole 6 is provided with a high-temperature-resistant mesh 5 with a pore size less than 500 microns.

[0080] The magnesium-based particles 2 are degraded earlier than the zinc-based body 1 in the process of being implanted into a human body, the zinc-based body forms a zinc-based bone repair bracket with a connected porous structure after the magnesium-based particles are degraded, the preparation process is simple, no filling mold loss and no pore former residue are generated, the cleaning process after sodium chloride particles are filled is omitted, and the risk caused by local corrosion or incomplete cleaning in the cleaning process is avoided.

[0081] Embodiment 3

[0082] The embodiment relates to a degradable bone repair metal material formed by magnesium-based particles and a zinc matrix, the magnesium-based particle component is pure magnesium, the diameter of the magnesium-based particle is 200 microns, the magnesium-based particle is spherical, the magnesium-based particles 2 are in contact with each other, and the zinc matrix component is a zinc-copper alloy which fills the gaps between the magnesium-based particles 2 and wraps the magnesium-based particles 2.

[0083] The embodiment relates to a preparation method of the degradable bone repair metal material.

[0084] In step S(1), pure magnesium particles with a diameter of 200 microns are selected, and the pure magnesium particles are soaked in a hydrofluoric acid solution at room temperature for 24 hours, and then the pure magnesium particles are taken out, cleaned with alcohol and dried to obtain fluorinated pure magnesium particles.

[0085] In step S(2), the pure magnesium particles obtained in step S(1) are placed in a casting mold 4, and the pure magnesium particles are vibrated and compacted to make the pure magnesium particles closely contact with each other, so that the casting mold 4 filled with the pure magnesium particles is obtained.

[0086] In step S(3), the casting mold 4 filled with the pure magnesium particles obtained in step S(2) is placed in an oven at 400 DEG C for 1 hour.

[0087] In step S(4), a zinc-copper alloy is selected, and the zinc-copper alloy is heated and melted into a zinc-copper alloy melt under nitrogen protection.

[0088] In step S(5), the casting mold 4 in step S(3) is taken out from the oven, and the zinc-copper alloy melt in step S(4) is poured into the casting mold 4, and the pouring temperature is 500 DEG C.

[0089] In step S(6), after the casting mold 4 is cooled, the upper end and the lower end of the casting mold 4 are each cut off by 2 cm, and then the casting mold 4 is cleaned and dried to obtain a degradable bone repair metal material formed by the pure magnesium particles and a zinc-copper alloy shell.

[0090] The bottom of the casting mold 4 is provided with a through hole 6, and the through hole 6 is provided with a high-temperature-resistant mesh 5 with a pore size less than 200 microns.

[0091] The magnesium-based particles 2 are degraded earlier than the zinc matrix 1 in the process of being implanted into the human body, the zinc matrix forms a zinc-based bone repair scaffold with a connected porous structure after the magnesium-based particles are degraded, the preparation process is simple, no filling mold loss and no pore former residue are generated, the cleaning process after the sodium chloride particles are filled is omitted, and the risk of local corrosion or incomplete cleaning in the cleaning process is avoided.

[0092] The above detailed description merely illustrates feasible embodiments of the present application, and is not intended to limit the protection scope of the present application, and equivalent embodiments or changes made without departing from the spirit of the present application shall be included in the protection scope of the present application.

Claims

1. A biodegradable bone repair metal material, characterized in that, Includes a zinc matrix (1) and magnesium-based particles (2); The zinc matrix (1) encapsulates the magnesium particles (2). The zinc matrix (1) is formed by melting zinc-based metal to fill the gaps between the magnesium particles (2). The magnesium particles (2) have a fluorinated layer on their surface and are in close contact with each other. After being implanted into the human body, the magnesium particles (2) form an electric couple with the zinc matrix and degrade before the zinc matrix (1). After the magnesium particles (2) degrade, the zinc matrix (1) forms a zinc-based bone repair scaffold with a connected porous structure. The biodegradable bone repair metal material is prepared by the following method: Step S1: Select magnesium-based particles (2), place them in hydrofluoric acid solution, soak them at room temperature, take them out, wash them with alcohol and dry them to obtain fluorinated magnesium-based particles; Step S2: Place the fluorinated magnesium-based particles (2) obtained in step S1 into the casting mold (4), vibrate and compact them so that the magnesium-based particles (2) are in close contact with each other, and obtain the casting mold (4) containing the magnesium-based particles (2). Step S3: Place the casting mold (4) containing magnesium-based particles (2) obtained in step S2 in an oven for heat preservation; Step S4: Select zinc-based metal from zinc matrix (1), heat and melt it under nitrogen protection to form zinc-based melt; Step S5: Take out the casting mold (4) from the oven in step S3 and pour the zinc-based melt from step S4 into the casting mold (4); Step S6: After the casting mold (4) has cooled, take it out, cut off the parts without magnesium from both the top and bottom ends, clean and dry it to obtain a biodegradable bone repair metal material formed by magnesium-based particles (2) and zinc matrix (1).

2. The biodegradable bone repair metal material according to claim 1, characterized in that, The magnesium-based particles (2) are spherical in shape and have a diameter of 200-900 micrometers.

3. The biodegradable bone repair metal material according to claim 1, characterized in that, The magnesium-based particles (2) are composed of one of pure magnesium, magnesium-zinc alloy, or magnesium-calcium alloy; The zinc matrix (1) is composed of one of the following: pure zinc, zinc-lithium alloy, zinc-manganese alloy, zinc-magnesium alloy, zinc-calcium alloy, and zinc-copper alloy.

4. A method for preparing a biodegradable bone repair metal material according to any one of claims 1-3, characterized in that, Includes the following steps: Step S1: Select magnesium-based particles (2) with a diameter of 200-900 micrometers, put them into hydrofluoric acid solution, soak them at room temperature, take them out, wash them with alcohol and dry them to obtain fluorinated magnesium-based particles. Step S2: Place the fluorinated magnesium-based particles (2) obtained in step S1 into the casting mold (4), vibrate and compact them so that the magnesium-based particles (2) are in close contact with each other, and obtain the casting mold (4) containing the magnesium-based particles (2). Step S3: Place the casting mold (4) containing magnesium-based particles (2) obtained in step S2 in an oven at 350℃-400℃ for heat preservation; Step S4: Select zinc-based metal from zinc matrix (1), heat and melt it under nitrogen protection to form zinc-based melt; Step S5: Take out the casting mold (4) from the oven in step S3, pour the zinc-based melt from step S4 into the casting mold (4), and the casting temperature is 430℃-500℃. Step S6: After the casting mold (4) has cooled, take it out, cut off the parts without magnesium from both the top and bottom ends, clean and dry it to obtain a biodegradable bone repair metal material formed by magnesium-based particles (2) and zinc matrix (1).

5. The method for preparing the biodegradable bone repair metal material according to claim 4, characterized in that, In step S1, the magnesium-based particles (2) are placed in a hydrofluoric acid solution and soaked at room temperature for 24 hours.

6. The method for preparing the biodegradable bone repair metal material according to claim 4, characterized in that, The bottom of the casting mold (4) in step S2 has a through hole (6).

7. The method for preparing the biodegradable bone repair metal material according to claim 4, characterized in that, The overall heat preservation time of the casting mold (4) containing magnesium-based particles (2) in step S3 shall not be less than 1 hour.

8. The method for preparing the biodegradable bone repair metal material according to claim 4, characterized in that, In step S5, when the zinc-based melt is cast, a negative pressure environment is provided in the cavity of the casting mold (4) through the bottom through hole (6).

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