Skin care serum and preparation method thereof

Abstract

The present application relates to a kind of skin repair essence and its preparation method, the essence is made of the following weight percentage of each raw material: okra extract complex fluid 1.2-1.5%; willow extract complex fluid 0.5-0.8%; red factor complex fluid 0.4-0.6%; transdermal polypeptide complex fluid 0.1-0.3%; preservative 0.4-0.6%; thickening agent 0.2-0.4%; chelating agent 0.04-0.1%; pH regulator 0.05-0.1%; Humectant 9.5-10.5%; the rest is pure water.The skin repair essence provided by the present application has the following advantages: okra extract complex fluid, willow extract complex fluid, red factor complex fluid and transdermal polypeptide complex fluid are used as effective components for skin repair, which shows very significant effect in soothing skin, repairing sunburn, removing acne marks, removing red blood vessels and other aspects, and the synergistic effect of each component in realizing specific function is obvious.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a skin repair essence and a preparation method thereof. BACKGROUND

[0002] It is human nature to love beauty, and once the skin is damaged, it will greatly affect the beauty due to the problems such as red spots, acne, acne marks, peeling, oily light, etc. on the surface. The main reasons for skin damage are as follows: on the one hand, due to the wrong skin care concept, over-care, frequent use of strong cleaning, makeup removal or exfoliating products, leading to skin keratin damage and sebum membrane damage, and then causing skin redness, pain, dryness, etc. On the other hand, the cosmetic itself contains irritating ingredients or hormone ingredients, which damages the skin surface.

[0003] In view of the series of problems caused by skin damage, the current general method is to use cosmetics with skin repair function to repair damaged skin. However, some existing skin repair essences or repair creams also have the following problems more or less: some use a combination of a large number of plant extracts to achieve the purpose of repair, but too many types of plant extracts not only lead to complex preparation and high cost, but also have no obvious synergistic effect between each plant extract in repairing the skin, and the repair effect is general; some mainly use protease and / or vitamin E as effective components, which has the disadvantages of insufficient repair effect and basically targets the repair of traumatic skin, and the function is single. SUMMARY

[0004] The present application provides a skin repair essence and a preparation method thereof, which aims to use effective components such as okra extract, Canadian willow herb extract, redness-removing factor and transdermal polypeptide to reasonably match and cooperate, so as to achieve the purpose of multiple and efficient repair of the skin.

[0005] The technical scheme for solving the above technical problems is as follows: a skin repair essence is prepared from the following raw materials in the following weight percentages: okra extract complex liquid 1.2-1.5%; willow herb extract complex liquid 0.5-0.8%; redness-removing factor complex liquid 0.4-0.6%; transdermal polypeptide complex liquid 0.1-0.3%; preservative 0.4-0.6%; thickening agent 0.2-0.4%; chelating agent 0.04-0.1%; pH regulator 0.05-0.1%; humectant 9.5-10.5%; and the balance is pure water.

[0006] On the basis of the above technical scheme, the present application can also be further selected or more optimally selected as follows.

[0007] Specifically, the okra extract complex is composed of the following raw materials in weight percentages: 8% okra fruit extract; 4% propylene glycol; 4% bis-PEG-15 methyl ether polydimethylsiloxane; 1% hydrolyzed pectin; 0.3% phenoxyethanol; 0.3% chlorphenesin; and 82.4% water.

[0008] Specifically, the willowherb extract complex is composed of the following raw materials in weight percentages: willowherb extract 5%; phenoxyethanol 0.5%; sodium metabisulfite 0.1%; and water 94.4%.

[0009] Specifically, the redness-reducing compound solution is composed of the following raw materials in weight percentages: 10% chrysanthemum extract; 10% tea extract; 8.5% butylene glycol; 5% 1,2-pentanediol; 2% 1,3-propanediol; 0.5% lecithin; 0.5% magnolol; and 63.5% water.

[0010] Specifically, the transdermal polypeptide complex solution is composed of the following raw materials in weight percentages: decapeptide - 40.01%; glycoprotein - 0.01%; disodium hydrogen phosphate - 0.15%; sodium chloride - 0.9%; and water - 98.93%.

[0011] Specifically, the preservative is at least two of methylparaben, chlorphenesin, phenoxyethanol, and ethylhexylglycerin.

[0012] Specifically, the moisturizer is at least two of glycerin, propylene glycol, butylene glycol, and allantoin.

[0013] Preferably, the moisturizer is one of four types: glycerin, propylene glycol, butylene glycol, and allantoin, which account for 6%, 3%, 1%, and 0.2% of the weight of the essence, respectively.

[0014] Specifically, the thickener is xanthan gum and / or carbomer, the pH adjuster is aminomethylpropanol, the chelating agent is disodium EDTA, and the weight percentage of the purified water is 84.5-87.5%.

[0015] This invention also provides a method for preparing a skin repair serum, which includes the following steps:

[0016] S1. Prepare okra extract compound solution, willowherb extract compound solution, redness-reducing factor compound solution and transdermal polypeptide compound solution separately for later use;

[0017] S2. Add the humectant, thickener, preservative, chelating agent and purified water according to the corresponding weight percentage to the emulsification tank that has been sterilized with hot water. Heat to 70-75℃ while mixing and stirring, homogenize for 5-10 minutes, keep warm for 20 minutes, and then cool to 50-55℃ for later use.

[0018] S3. After cooling to 50-55℃ in S2, add the corresponding weight percentage of pH regulator to the material, homogenize and stir for 3-5 min, continue to cool to 38-40℃, and reserve;

[0019] S4. Add the corresponding weight percentage of the okra extract complex liquid, willow extract complex liquid, redness-removing factor complex liquid and transdermal polypeptide complex liquid to the material cooled to 38-40℃ in S3, homogenize for 3-5 min, continue to stir for 10 min, and cool to room temperature to obtain the product.

[0020] Compared with the prior art, the beneficial effects of the present application are:

[0021] The skin care essence provided by the present application uses okra extract complex liquid, willow extract complex liquid, redness-removing factor complex liquid and transdermal polypeptide complex liquid as effective components for skin care, which shows very significant effects in soothing and tenderizing the skin, repairing sunburn red spots, removing acne marks, and removing red blood vessels.

[0022] The okra extract complex liquid and willow extract complex liquid are used together for the first time, and the two have outstanding synergistic effects in tenderizing the skin and repairing sunburn red spots. When either of the two is used alone, even if the dosage is increased, it cannot achieve the good effects of the two used in appropriate proportions. In addition, the above two components can also be used to enhance the effect of removing acne marks in cooperation with the transdermal polypeptide and redness-removing factor complex liquids. In the formula of the present application, the redness-removing factor complex liquid and the transdermal polypeptide complex liquid are used together, and the effects of removing red blood vessels and removing acne marks are good, and effects that cannot be achieved by using either of the two components alone can be achieved.

[0023] The preparation method provided by the present application is relatively simple. The complex liquids are prepared in advance and then used according to the dosage, and the remaining components are mixed and homogenized according to the steps. The complex liquids can be prepared in advance and loaded into the raw material tank for quantitative feeding as needed, which is conducive to the rapid and efficient production of skin care liquid products in the factory. DETAILED DESCRIPTION

[0024] The present application will be further described in detail below in combination with specific examples, and the examples are only used to explain the present application and are not used to limit the scope of the present application.

[0025] For the sake of brevity, the raw materials used in the following examples are all commercially available products or products prepared by those skilled in the art according to existing methods unless otherwise specified. The methods used are all conventional methods in the art unless otherwise specified.

[0026] The willow extract is a Canadian willow flower, leaf and stem extract with a specification of 10:1 and a brownish yellow powder.

[0027] The preparation method of the skin care serum in each of the following examples and comparative examples comprises the following steps (if a raw material is missing in the comparative example, the corresponding step will not add the raw material) :

[0028] S1. Prepare the okra extract composite liquid, willow extract composite liquid, red factor composite liquid and transdermal polypeptide composite liquid respectively, and reserve them;

[0029] S2. Add the moisturizing agent, thickening agent, preservative, chelating agent and pure water according to the corresponding weight percentage to the emulsifying cylinder treated with hot water sterilization, mix and stir while heating to 70-75℃, homogenize for 5-10min, keep warm for 20min, and then cool to 50-55℃, and reserve;

[0030] S3. Add the pH regulator according to the corresponding weight percentage to the material cooled to 50-55℃ in S2, homogenize and stir for 3-5min, continue to cool to 38-40℃, and reserve;

[0031] S4. Add the okra extract composite liquid, willow extract composite liquid, red factor composite liquid and transdermal polypeptide composite liquid according to the corresponding weight percentage to the material cooled to 38-40℃ in S3, homogenize for 3-5min, continue to stir for 10min, and then cool to room temperature.

[0032] The skin care serum provided by the application is a transparent viscous liquid, and has a special smell after mixing of each raw material.

[0033] Example 1

[0034] A skin care serum is prepared from the following weight percentage of each raw material: okra extract composite liquid 1.4%; willow extract composite liquid 0.65%; red factor composite liquid 0.5%; transdermal polypeptide composite liquid 0.2%; preservative 0.55%; thickening agent 0.35%; chelating agent 0.05%; pH regulator 0.08%; moisturizing agent 10.2%; and pure water 86.02%. The specific composition and corresponding content of each raw material are shown in the following table:

[0035]

[0036]

[0037] Example 2

[0038] A skin care essence is prepared from the following ingredients in the indicated amounts: 1.2% abelmoschus extract complex, 0.8% willow extract complex, 0.6% redness-removing factor complex, 0.3% transdermal polypeptide complex, 0.6% preservative, 0.4% thickening agent, 0.06% chelating agent, 0.07% pH regulator, 10.5% humectant, and 85.47% purified water. The specific composition and corresponding amounts of each ingredient are shown in the following table:

[0039]

[0040]

[0041] Example 3

[0042] A skin care essence is prepared from the following ingredients in the indicated amounts: 1.5% abelmoschus extract complex, 0.5% willow extract complex, 0.4% redness-removing factor complex, 0.1% transdermal polypeptide complex, 0.4% preservative, 0.2% thickening agent, 0.04% chelating agent, 0.09% pH regulator, 9.5% humectant, and 87.27% purified water. The specific composition and corresponding amounts of each ingredient are shown in the following table:

[0043]

[0044]

[0045] Example 4

[0046] A skin care essence is prepared from the following ingredients in the indicated amounts: 1.4% abelmoschus extract complex, 0.65% willow extract complex, 0.5% redness-removing factor complex, 0.2% transdermal polypeptide complex, 0.55% preservative, 0.35% thickening agent, 0.05% chelating agent, 0.08% pH regulator, 10.2% humectant, and 86.02% purified water. The amounts of each ingredient are the same as in Example 1, except that the proportions of the internal components of the humectant and preservative are different from those in Example 1. The specific composition and corresponding amounts of each ingredient are shown in the following table:

[0047]

[0048]

[0049] Comparative Example 1

[0050] Comparative Example 1 is the same as Example 1, except that it does not contain willow extract complex.

[0051] Comparative Example 2

[0052] Comparative Example 2 does not contain the composite solution of okra extract only compared with Example 1.

[0053] Comparative Example 3

[0054] Comparative Example 3 does not contain the composite solution of willow extract only compared with Example 1, and the weight percentage of the composite solution of okra extract in the serum is increased to 2.05% (i.e. the corresponding weight percentage of the missing composite solution of willow extract is fully supplemented by the composite solution of okra extract). The corresponding contents of each component in the composite solution of okra extract in the adjusted serum are as follows:

[0055]

[0056] Comparative Example 4

[0057] Comparative Example 4 does not contain the composite solution of redness-removing factor only compared with Example 1.

[0058] Comparative Example 5

[0059] Comparative Example 5 does not contain the composite solution of transdermal polypeptide only compared with Example 1.

[0060] Comparative Example 6

[0061] Comparative Example 6 does not contain the composite solution of transdermal polypeptide only compared with Example 1, and the weight percentage of the composite solution of redness-removing factor in the serum is increased to 0.7% (i.e. the corresponding weight percentage of the missing composite solution of transdermal polypeptide is fully supplemented by the composite solution of redness-removing factor). The corresponding contents of each component in the composite solution of redness-removing factor in the adjusted serum are as follows:

[0062]

[0063]

[0064] Test Example

[0065] To verify the safety of the skin repair serum provided by the present application, the repair serum of each embodiment of the present application was detected according to the "human skin patch test" content recorded in Chapter 7 Human Safety Test Method Section 2 of "Cosmetic Safety Technical Specification (2022 Edition)", to determine whether it would cause adverse reactions to human skin:

[0066] According to the specification requirements, 36 qualified volunteers (18-60 years old) were selected as the test subjects to conduct the skin closed patch test. During the test, 0.025 mL of the corresponding example serum product was added to each chamber of the patch tester. The control hole was blank. The patch tester was attached to the flexor side of the test subject's forearm with a low sensitization tape for 24 hours. Then, the skin reaction was observed and the observation results were recorded at 30 minutes, 24 hours and 48 hours after the patch tester was removed, respectively. The test results are shown in the following table:

[0067]

[0068] Note: "-" represents a negative reaction; "±" represents a suspicious reaction with only weak erythema; "+" represents a weak positive reaction (erythema reaction): erythema, infiltration, edema, and possibly papules; "++" represents a strong positive reaction (vesicle reaction): erythema, infiltration, edema, papules, and vesicles; the reaction can exceed the test area; "+++" represents an extremely strong positive reaction (fusion vesicle reaction): obvious erythema, severe infiltration, edema, and fusion vesicles; the reaction exceeds the test area.

[0069] As shown in the above table, the skin repair serum provided by the present application can successfully pass the skin closed patch test with good results, and basically all negative reactions occur without adverse reactions such as edema, papules or vesicles. In examples 2 and 3, 1-2 skin suspicious reactions occur with only weak erythema. According to the evaluation principle (in 30 test subjects, the number of skin adverse reactions at the "±" level should not exceed 5 to indicate that the test substance will not cause adverse reactions to human skin), it can be known that the product provided by each example of the present application is relatively mild and can pass the skin closed patch test.

[0070] For safety, in order to ensure that examples 2 and 3 have a small amount of skin suspicious reaction, the product of examples 2 and 3 was subjected to a repeated open smearing test. In the repeated open smearing test, 0.050 mL of the corresponding example serum product was applied to the 3 cm x 3 cm area of the flexor side of the test subject's forearm each time, and was evenly applied twice a day for 7 consecutive days. The skin reaction was observed on the 8th, 9th and 10th days, respectively. The results are shown in the following table:

[0071]

[0072] As shown in the above table, the skin repair serum provided by the present application can successfully pass the skin closed patch test with good results, and basically all negative reactions occur without adverse reactions such as edema, papules or vesicles. In examples 2 and 3, 1-2 skin suspicious reactions occur with only weak erythema. According to the evaluation principle (in 30 test subjects, the number of skin adverse reactions at the "±" level should not exceed 5 to indicate that the test substance will not cause adverse reactions to human skin), it can be known that the product provided by each example of the present application is relatively mild and can pass the skin closed patch test.

[0073] To verify the soothing and skin-smoothing effect of the skin care serum provided by the present application and the effect of repairing after-sun erythema, 100 test subjects (aged 35-55 years old) with rough, loose, and obvious fine lines or after-sun erythema on the skin were selected and randomly divided into five groups, and the products of Example 1, Comparative Examples 1-3, and a commercially available similar product (a latest generation of black serum of a certain brand) were used respectively. The test area was the face, and the corresponding product was applied to the face after washing the face in the morning and evening every day. After continuous use for 5 weeks, the test subjects self-evaluated the use effect, and according to the comparison of the skin roughness, looseness, obvious fine lines, or after-sun erythema on the face before and after use, A+, A, B+, B, and C five grades were distinguished, wherein A+ grade means that the improvement is very obvious, for example, the rough and loose skin becomes obviously smoother and tighter than before or most of the fine lines and after-sun erythema disappear, A grade means that the improvement is obvious, and the skin condition is improved by naked eye, for example, the fine lines and after-sun erythema are reduced by at least 50% after use compared with before use, B+ grade means that the improvement can be seen after careful comparison before and after use, B grade means that the improvement is not obvious, and C grade means that there is no improvement or even the condition becomes worse. The test results are shown in the following table:

[0074] Group A+ A B+ B C Example 1 10 7 3 0 0 Comparative Example 1 3 8 7 2 0 Comparative Example 2 5 4 8 3 Comparative Example 3 4 8 6 2 0 Competitor 7 5 5 3 0

[0075] As can be seen from the above table, the skin-smoothing and after-sun erythema repairing effect of the skin care serum provided by the present application is obviously better than that of the commercially available similar product, and it can be analyzed from the above data that the willow extract composite liquid and the okra extract composite liquid have obvious synergistic effect on skin-smoothing and after-sun erythema repair.

[0076] Finally, in order to verify the effect of the skin care serum provided by the present application on removing red blood vessels and acne marks, the following test was performed.

[0077] The test for removing acne marks selected people aged 16-22 years old with obvious acne marks on the face as test subjects, and the number of people was 100. They were randomly divided into five groups, and the products corresponding to Example 1, Comparative Example 1, and Comparative Examples 4-6 were used. The corresponding product was applied to the face after washing the face in the morning and evening every day. After continuous use for three weeks, the effect of removing acne marks was evaluated: excellent - the removal rate of acne marks was more than 65%; good - the removal rate of acne marks was more than 35%; and poor - the removal rate of acne marks was less than 35%. The test results are shown in the following table:

[0078] Group Excellent Good Poor Example 1 11 9 0 Comparative Example 1 10 6 4 Comparative Example 4 7 6 7 Comparative Example 5 5 6 9 Comparative Example 6 7 10 2

[0079] As can be seen from the above table, the skin care serum provided by the present application has good effect on removing acne marks, and the redness-removing factor composite liquid and the transdermal polypeptide composite liquid have obvious synergistic effect on removing acne marks. In addition, it can be analyzed that the willow extract composite liquid also has obvious contribution to removing acne marks.

[0080] The test for removing red blood vessels selected 80 subjects with obvious red blood vessels on the skin, and randomly divided them into four groups. The products corresponding to the examples 1 and comparative examples 4 to 6 were used, and the corresponding products were applied to the selected area of the skin after washing every morning and evening, for 3 months. At the beginning of the test, the red pigment value of the subjects was determined, and the value was recorded by using Mexamter MX18 (pigment test probe) for detection. Then, the red pigment value was determined again after the test period of 3 months. The effect of removing red blood vessels was judged by the inhibition of red pigment before and after the test (inhibition rate), and the calculation method of the inhibition rate was as follows: inhibition rate = (red pigment value before use - red pigment value after use) x 100% / red pigment value before use; excellent: inhibition rate ≥ 20%; good: inhibition rate = 5% to 20%; poor: inhibition rate < 5%. The final statistical results are shown in the following table:

[0081] Group Excellent Good Poor Example 1 8 12 0 Comparative Example 4 2 7 11 Comparative Example 5 4 10 6 Comparative Example 6 4 12 4

[0082] From the above table, it can be seen that the repair serum provided by the present application has good effect of removing red blood vessels, and the red blood factor complex liquid and the transdermal polypeptide complex liquid have obvious synergistic effect on the effect of removing red blood vessels on the surface of the skin.

[0083] The above description is only the preferred embodiment of the present application, and is not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A skin repair essence, characterized in that, It is made from the following raw materials in weight percentages: okra extract complex 1.2-1.5%; willowherb extract complex 0.5-0.8%; redness-reducing factor complex 0.4-0.6%; transdermal polypeptide complex 0.1-0.3%; preservative 0.4-0.6%; thickener 0.2-0.4%; chelating agent 0.04-0.1%; pH adjuster 0.05-0.1%; humectant 9.5-10.5%; the balance is purified water; The okra extract compound is composed of the following raw materials in weight percentages: okra fruit extract 8%; propylene glycol 4%; bis-PEG-15 methyl ether polydimethylsiloxane 4%; hydrolyzed pectin 1%; phenoxyethanol 0.3%; chlorphenesin 0.3%; and water 82.4%. The willowherb extract compound solution is composed of the following raw materials in weight percentages: willowherb extract 5%; phenoxyethanol 0.5%; sodium metabisulfite 0.1%; water 94.4%; The redness-reducing compound solution is composed of the following raw materials in the indicated weight percentages: 10% chrysanthemum extract; 10% tea extract; 8.5% butylene glycol; 5% 1,2-pentanediol; 2% 1,3-propanediol; 0.5% lecithin; 0.5% magnolol; and 63.5% water. The transdermal polypeptide complex solution is composed of the following raw materials in weight percentages: decapeptide-4 0.01%; glycoprotein 0.01%; disodium hydrogen phosphate 0.15%; sodium chloride 0.9%; and water 98.93%.

2. The skin repair essence according to claim 1, characterized in that, The preservative is at least two of the following: methylparaben, chlorphenesin, phenoxyethanol, and ethylhexylglycerin.

3. The skin repair essence according to claim 1, characterized in that, The moisturizer is at least two of the following: glycerin, propylene glycol, butylene glycol, and allantoin.

4. The skin repair essence according to claim 3, characterized in that, The moisturizers are glycerin, propylene glycol, butylene glycol and allantoin, which account for 6%, 3%, 1% and 0.2% of the weight of the essence, respectively.

5. The skin repair essence according to claim 1, characterized in that, The thickener is xanthan gum and / or carbomer, the pH adjuster is aminomethylpropanol, the chelating agent is disodium EDTA, and the weight percentage of the purified water is 84.5-87.5%.

6. A method for preparing a skin repair essence as described in any one of claims 1 to 5, characterized in that, Includes the following steps: S1. Prepare okra extract compound solution, willowherb extract compound solution, redness-reducing factor compound solution and transdermal polypeptide compound solution separately for later use; S2. Add the humectant, thickener, preservative, chelating agent and purified water according to the corresponding weight percentage to the emulsification tank that has been sterilized with hot water. Heat to 70-75℃ while mixing and stirring, homogenize for 5-10 minutes, keep warm for 20 minutes, and then cool to 50-55℃ for later use. S3. Add the appropriate weight percentage of pH adjuster to the material in S2 after it has been cooled to 50-55℃, homogenize and stir for 3-5 minutes, and continue to cool to 38-40℃ for later use; S4. Add the okra extract complex, willowherb extract complex, redness-reducing factor complex and transdermal peptide complex to the material cooled to 38-40℃ in S3 according to the corresponding weight percentage, homogenize for 3-5 minutes, continue stirring for 10 minutes, and cool to room temperature to obtain the final product.

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